Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	ref_context	gc_content	COSMIC_n_overlapping_mutations	ESP_AvgAAsampleReadDepth	ESP_AvgEAsampleReadDepth	ESP_AvgSampleReadDepth	ESP_Chromosome	ESP_Position	ESP_TotalAAsamplesCovered	ESP_TotalEAsamplesCovered	ESP_TotalSamplesCovered	Ensembl_so_accession	Ensembl_so_term	HGNC_AccessionNumbers	HGNC_CCDSIDs	HGNC_Chromosome	HGNC_DateModified	HGNC_DateNameChanged	HGNC_DateSymbolChanged	HGNC_EnsemblGeneID	HGNC_EnsemblIDsuppliedbyEnsembl	HGNC_Genefamilydescription	HGNC_HGNCID	HGNC_LocusGroup	HGNC_LocusType	HGNC_NameSynonyms	HGNC_OMIMIDsuppliedbyNCBI	HGNC_PreviousNames	HGNC_PreviousSymbols	HGNC_PubmedIDs	HGNC_RecordType	HGNC_RefSeqsuppliedbyNCBI	HGNC_Status	HGNC_Synonyms	HGNC_UCSCIDsuppliedbyUCSC	HGNC_UniProtIDsuppliedbyUniProt	HGNC_VEGAIDs	HGVS_coding_DNA_change	HGVS_genomic_change	HGVS_protein_change	UniProt_alt_uniprot_accessions	annotation_transcript	build	ccds_id	dbNSFP_1000Gp1_AC	dbNSFP_1000Gp1_AF	dbNSFP_1000Gp1_AFR_AC	dbNSFP_1000Gp1_AFR_AF	dbNSFP_1000Gp1_AMR_AC	dbNSFP_1000Gp1_AMR_AF	dbNSFP_1000Gp1_ASN_AC	dbNSFP_1000Gp1_ASN_AF	dbNSFP_1000Gp1_EUR_AC	dbNSFP_1000Gp1_EUR_AF	dbNSFP_Ancestral_allele	dbNSFP_CADD_phred	dbNSFP_CADD_raw	dbNSFP_CADD_raw_rankscore	dbNSFP_ESP6500_AA_AF	dbNSFP_ESP6500_EA_AF	dbNSFP_Ensembl_geneid	dbNSFP_Ensembl_transcriptid	dbNSFP_FATHMM_pred	dbNSFP_FATHMM_rankscore	dbNSFP_FATHMM_score	dbNSFP_GERP_NR	dbNSFP_GERP_RS	dbNSFP_GERP_RS_rankscore	dbNSFP_Interpro_domain	dbNSFP_LRT_Omega	dbNSFP_LRT_converted_rankscore	dbNSFP_LRT_pred	dbNSFP_LRT_score	dbNSFP_LR_pred	dbNSFP_LR_rankscore	dbNSFP_LR_score	dbNSFP_MutationAssessor_pred	dbNSFP_MutationAssessor_rankscore	dbNSFP_MutationAssessor_score	dbNSFP_MutationTaster_converted_rankscore	dbNSFP_MutationTaster_pred	dbNSFP_MutationTaster_score	dbNSFP_Polyphen2_HDIV_pred	dbNSFP_Polyphen2_HDIV_rankscore	dbNSFP_Polyphen2_HDIV_score	dbNSFP_Polyphen2_HVAR_pred	dbNSFP_Polyphen2_HVAR_rankscore	dbNSFP_Polyphen2_HVAR_score	dbNSFP_RadialSVM_pred	dbNSFP_RadialSVM_rankscore	dbNSFP_RadialSVM_score	dbNSFP_Reliability_index	dbNSFP_SIFT_converted_rankscore	dbNSFP_SIFT_pred	dbNSFP_SIFT_score	dbNSFP_SLR_test_statistic	dbNSFP_SiPhy_29way_logOdds	dbNSFP_SiPhy_29way_logOdds_rankscore	dbNSFP_SiPhy_29way_pi	dbNSFP_UniSNP_ids	dbNSFP_Uniprot_aapos	dbNSFP_Uniprot_acc	dbNSFP_Uniprot_id	dbNSFP_aaalt	dbNSFP_aapos	dbNSFP_aapos_FATHMM	dbNSFP_aapos_SIFT	dbNSFP_aaref	dbNSFP_cds_strand	dbNSFP_codonpos	dbNSFP_folddegenerate	dbNSFP_genename	dbNSFP_hg18_pos1coor	dbNSFP_phastCons100way_vertebrate	dbNSFP_phastCons100way_vertebrate_rankscore	dbNSFP_phastCons46way_placental	dbNSFP_phastCons46way_placental_rankscore	dbNSFP_phastCons46way_primate	dbNSFP_phastCons46way_primate_rankscore	dbNSFP_phyloP100way_vertebrate	dbNSFP_phyloP100way_vertebrate_rankscore	dbNSFP_phyloP46way_placental	dbNSFP_phyloP46way_placental_rankscore	dbNSFP_phyloP46way_primate	dbNSFP_phyloP46way_primate_rankscore	dbNSFP_refcodon	gencode_transcript_name	gencode_transcript_status	gencode_transcript_tags	gencode_transcript_type	gene_type	havana_transcript	init_n_lod	init_t_lod	isArtifactMode	n_alt_count	n_ref_count	oxoGCut	pox	pox_cutoff	qox	refseq_mrna_id	t_alt_count	t_lod_fstar	t_ref_count	tumor_f
FAM69B	0	broad.mit.edu	hg19	9	139620492	139620492	+	RNA	SNP	A	A	G			TCGA-WC-A87W-01A-11D-A39W-08	TCGA-WC-A87W-10A-01D-A39Z-08							Unknown	Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b97d5cc-c7d2-4d27-87cb-4c5090079458	addacac8-7364-409d-adce-53703cafaea2	g.chr9:139620492A>G	ENST00000414282.1	-	0	451				SNHG7_ENST00000447221.1_RNA|SNHG7_ENST00000416970.1_RNA|SNHG7_ENST00000436596.1_RNA																	TCCCTCATGGAGCAAACCAGG	0.502	0									SO:0001628	intergenic_variant		CCDS7004.1	9q34.3	2012-08-03			ENSG00000165716	ENSG00000165716		28290	protein-coding gene	gene with protein product		614543			21334309	Standard	NM_152421	Approved	MGC20262, C9orf136	uc004cik.3	Q5VUD6	OTTHUMG00000020940		9.37:g.139620492A>G		Q5VUD7|Q8N5N0|Q8WYU5	ENST00000371692.4	37	CCDS7004.1																																																																																			FAM69B-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000055102.1		-0.705156	0	12	86	0	0	1	0	NM_152421	3	6.972752	38	0.073171
IGSF11	152404	broad.mit.edu	hg19	3	118824025	118824025	+	Silent	SNP	T	T	C			TCGA-WC-A87W-01A-11D-A39W-08	TCGA-WC-A87W-10A-01D-A39Z-08							Unknown	Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b97d5cc-c7d2-4d27-87cb-4c5090079458	addacac8-7364-409d-adce-53703cafaea2	g.chr3:118824025T>C	ENST00000354673.2	-	3	395	c.15A>G	c.(13-15)gaA>gaG	p.E5E	IGSF11_ENST00000441144.2_Silent_p.E5E|IGSF11_ENST00000425327.2_Silent_p.E5E	NM_152538.2	NP_689751.2	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11	0		cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity	autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34					AGAGCAAAAGTTCCACCAGAG	0.358	0	110.0	106.0	107.0	3	118824025	2203	4300	6503	SO:0001819	synonymous_variant	AB079879	CCDS2983.1, CCDS46891.1	3q21.2	2013-01-11			ENSG00000144847	ENSG00000144847	"""Immunoglobulin superfamily / I-set domain containing"""	16669	protein-coding gene	gene with protein product	"""cancer/testis antigen 119"""	608351			12207903	Standard	XM_006713516	Approved	BT-IgSF, MGC35227, Igsf13, VSIG3, CT119	uc003ebw.3	Q5DX21	OTTHUMG00000159387	ENST00000425327.2:c.15A>G	3.37:g.118824025T>C		C9JZN0|Q8N4F1|Q8N7T8|Q8NDD2	ENST00000425327.2	37	CCDS2983.1																																																																																			IGSF11-001	KNOWN	basic|CCDS	protein_coding	protein_coding	OTTHUMT00000355074.2		38.996391	0	-21	36	0	0	1	0		12	39.029962	14	0.461538
ITPR2	3709	ucsc.edu	hg19	12	26596576	26596576	+	Missense_Mutation	SNP	C	C	T			TCGA-WC-A87W-01A-11D-A39W-08	TCGA-WC-A87W-10A-01D-A39Z-08	C	C					Unknown	Untested	Somatic	Phase_I	WXS	none			Illumina HiSeq	5b97d5cc-c7d2-4d27-87cb-4c5090079458	addacac8-7364-409d-adce-53703cafaea2																										TTTATTGTGGCGGGCCAACTA	0.423	0	129.0	119.0	122.0	12	26596576	1877	4116	5993	SO:0001583	missense	D26350	CCDS41764.1	12p11.23	2014-07-18	2011-04-28		ENSG00000123104	ENSG00000123104	"""Ion channels / Inositol triphosphate receptors"""	6181	protein-coding gene	gene with protein product	"""cilia and flagella associated protein 48"""	600144	"""inositol 1,4,5-triphosphate receptor, type 2"""		8081734	Standard	XM_006719064	Approved	IP3R2, CFAP48	uc001rhg.3	Q14571	OTTHUMG00000169181	ENST00000381340.3:c.6350G>A	12.37:g.26596576C>T	ENSP00000370744:p.Arg2117His	O94773	ENST00000381340.3	37	CCDS41764.1	.	.	.	.	.	.	.	.	.	.	C	17.05	3.290020	0.59976	.	.	ENSG00000123104	ENST00000381340	D	0.92048	-2.96	4.87	4.87	0.63330	.	0.000000	0.85682	D	0.000000	D	0.94009	0.8081	L	0.41710	1.295	0.80722	D	1	D	0.89917	1.0	D	0.78314	0.991	D	0.93283	0.6662	10	0.40728	T	0.16	.	18.5753	0.91153	0.0:1.0:0.0:0.0	.	2117	Q14571	ITPR2_HUMAN	H	2117	ENSP00000370744:R2117H	ENSP00000370744:R2117H	R	-	2	0	ITPR2	26487843	1.000000	0.71417	1.000000	0.80357	0.950000	0.60333	7.342000	0.79310	2.692000	0.91855	0.655000	0.94253	CGC	ITPR2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000402732.1				13	67					NM_002223	4		38	
KIAA1549	57670	broad.mit.edu	hg19	7	138552831	138552831	+	Missense_Mutation	SNP	C	C	T			TCGA-WC-A87W-01A-11D-A39W-08	TCGA-WC-A87W-10A-01D-A39Z-08							Unknown	Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b97d5cc-c7d2-4d27-87cb-4c5090079458	addacac8-7364-409d-adce-53703cafaea2	g.chr7:138552831C>T	ENST00000440172.1	-	15	4867	c.4819G>A	c.(4819-4821)Gtc>Atc	p.V1607I	KIAA1549_ENST00000242365.4_Missense_Mutation_p.V1557I|KIAA1549_ENST00000422774.1_Missense_Mutation_p.V1607I	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	1607			integral to membrane		large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7					CAGCCGTTGACCTGGTGTTTC	0.552	0	50.0	58.0	56.0	7	138552831	2057	4191	6248	SO:0001583	missense		CCDS47723.1, CCDS47723.2, CCDS56513.1	7q34	2009-10-09			ENSG00000122778	ENSG00000122778		22219	protein-coding gene	gene with protein product		613344				Standard	NM_020910	Approved		uc011kql.2	Q9HCM3	OTTHUMG00000157214	ENST00000422774.1:c.4819G>A	7.37:g.138552831C>T	ENSP00000416040:p.Val1607Ile	B6HY55|B6HY56|B6HY58|B6HY60|B6HY61|B6HY62|B6HY63|B6HY64|B6HY65|B6HY66|Q5BJD6|Q8IY15|Q9H0M3	ENST00000422774.1	37	CCDS56513.1	.	.	.	.	.	.	.	.	.	.	C	6.767	0.510352	0.12883	.	.	ENSG00000122778	ENST00000440172;ENST00000242365;ENST00000422774	T;T;T	0.21734	1.99;2.0;2.0	4.53	3.64	0.41730	.	0.324362	0.32655	N	0.005815	T	0.04497	0.0123	N	0.00707	-1.245	0.26509	N	0.974629	B;B;B;B	0.29552	0.248;0.0;0.208;0.0	B;B;B;B	0.25884	0.064;0.001;0.038;0.001	T	0.37798	-0.9690	10	0.06625	T	0.88	.	8.2926	0.31967	0.0:0.8437:0.0:0.1563	.	1607;391;1607;391	Q9HCM3;Q9HCM3-4;Q9HCM3-2;Q9HCM3-3	K1549_HUMAN;.;.;.	I	1607;1557;1607	ENSP00000406661:V1607I;ENSP00000242365:V1557I;ENSP00000416040:V1607I	ENSP00000242365:V1557I	V	-	1	0	KIAA1549	138203371	1.000000	0.71417	1.000000	0.80357	0.979000	0.70002	1.542000	0.36137	2.493000	0.84123	0.655000	0.94253	GTC	KIAA1549-002	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000348092.1		23.193056	0	-11	32	0	0	1	0		8	23.782943	16	0.333333
RNF213	57674	broad.mit.edu	hg19	17	78332109	78332109	+	Silent	SNP	C	C	T			TCGA-WC-A87W-01A-11D-A39W-08	TCGA-WC-A87W-10A-01D-A39Z-08							Unknown	Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b97d5cc-c7d2-4d27-87cb-4c5090079458	addacac8-7364-409d-adce-53703cafaea2	g.chr17:78332109C>T	ENST00000582970.1	+	37	11027	c.10884C>T	c.(10882-10884)gtC>gtT	p.V3628V	RNF213_ENST00000336301.6_Silent_p.V1701V|CTD-2047H16.4_ENST00000575034.1_RNA|CTD-2047H16.4_ENST00000572151.1_RNA|RNF213_ENST00000508628.2_Silent_p.V3677V	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0					NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)		GGAAGCGGGTCCAAGGTGCTG	0.572	0	70.0	61.0	64.0	17	78332109	2203	4300	6503	SO:0001819	synonymous_variant	AK074030	CCDS58606.1	17q25.3	2013-01-09	2007-02-08	2007-02-08		ENSG00000173821	"""RING-type (C3HC4) zinc fingers"""	14539	protein-coding gene	gene with protein product		613768	"""chromosome 17 open reading frame 27"", ""KIAA1618"", ""moyamoya disease 2"", ""Moyamoya disease 2"""	C17orf27, KIAA1618, MYMY2	10997877, 21048783, 21799892	Standard	NM_020954	Approved	KIAA1554, NET57	uc021uen.2	Q63HN8		ENST00000508628.2:c.11031C>T	17.37:g.78332109C>T		C9JCP4|D6RI12|F8WKS1|Q658P6|Q69YK7|Q6MZR1|Q8IWF4|Q8IZX1|Q8IZX2|Q8N406|Q8TEU0|Q9H6C9|Q9H6H9|Q9H6P3|Q9H8A9|Q9HCF4|Q9HCL8	ENST00000508628.2	37																																																																																				RNF213-001	NOVEL	basic|appris_candidate_longest|exp_conf	protein_coding	protein_coding	OTTHUMT00000364861.3		33.488526	0	-19	43	0	0	1	0	NM_020914	12	34.373886	24	0.333333
SCN11A	11280	broad.mit.edu	hg19	3	38938527	38938527	+	Missense_Mutation	SNP	G	G	T			TCGA-WC-A87W-01A-11D-A39W-08	TCGA-WC-A87W-10A-01D-A39Z-08							Unknown	Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b97d5cc-c7d2-4d27-87cb-4c5090079458	addacac8-7364-409d-adce-53703cafaea2	g.chr3:38938527G>T	ENST00000450244.1	-	14	2410	c.2212C>A	c.(2212-2214)Ccg>Acg	p.P738T	SCN11A_ENST00000456224.3_Missense_Mutation_p.P738T|SCN11A_ENST00000444237.2_Missense_Mutation_p.P738T|SCN11A_ENST00000302328.3_Missense_Mutation_p.P738T			Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	738		response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity	NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	GGGCCTGTCGGGTTACAGAGT	0.502	0	101.0	92.0	95.0	3	38938527	2203	4300	6503	SO:0001583	missense	AF126739	CCDS33737.1	3p22.2	2012-02-26	2007-01-23		ENSG00000168356	ENSG00000168356	"""Sodium channels"", ""Voltage-gated ion channels / Sodium channels"""	10583	protein-coding gene	gene with protein product		604385	"""sodium channel, voltage-gated, type XI, alpha polypeptide"", ""sodium channel, voltage-gated, type XII, alpha"""	SCN12A	10444332, 16382098	Standard	NM_014139	Approved	Nav1.9, NaN, SNS-2	uc021wvy.1	Q9UI33	OTTHUMG00000048246	ENST00000302328.3:c.2212C>A	3.37:g.38938527G>T	ENSP00000307599:p.Pro738Thr	A6NN05|C9JD48|C9JR31|Q68K15|Q8NDX3|Q9UHE0|Q9UHM0	ENST00000302328.3	37	CCDS33737.1	.	.	.	.	.	.	.	.	.	.	G	0.972	-0.699833	0.03279	.	.	ENSG00000168356	ENST00000302328;ENST00000450244;ENST00000456224;ENST00000444237	D;D;D;D	0.96136	-3.92;-3.92;-3.87;-3.74	0.225	0.225	0.15325	Ion transport (1);	17.326200	0.00166	N	0.000001	D	0.95169	0.8434	M	0.86178	2.8	0.09310	N	1	B	0.14805	0.011	B	0.12837	0.008	T	0.80167	-0.1495	10	0.56958	D	0.05	.	5.9124	0.19035	1.0E-4:0.0:0.9999:0.0	.	738	Q9UI33	SCNBA_HUMAN	T	738	ENSP00000307599:P738T;ENSP00000400945:P738T;ENSP00000416757:P738T;ENSP00000408028:P738T	ENSP00000307599:P738T	P	-	1	0	SCN11A	38913531	0.000000	0.05858	0.002000	0.10522	0.021000	0.10359	-4.182000	0.00278	0.300000	0.22699	0.305000	0.20034	CCG	SCN11A-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000109746.4		48.057952	1	3	48	0	2.4624e-09	1	2.4624e-09	NM_014139	17	48.959080	31	0.354167
BRINP3	339479	broad.mit.edu	hg19	1	190067401	190067401	+	Missense_Mutation	SNP	A	A	G			TCGA-WC-A87W-01A-11D-A39W-08	TCGA-WC-A87W-10A-01D-A39Z-08							Unknown	Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b97d5cc-c7d2-4d27-87cb-4c5090079458	addacac8-7364-409d-adce-53703cafaea2	g.chr1:190067401A>G	ENST00000367462.3	-	8	2279	c.2048T>C	c.(2047-2049)cTg>cCg	p.L683P	BRINP3_ENST00000534846.1_Missense_Mutation_p.L581P	NM_199051.1	NP_950252.1			bone morphogenetic protein/retinoic acid inducible neural-specific 3	683											CTGCAAAATCAGGTCCCGAAT	0.458	0	109.0	108.0	109.0	1	190067401	2203	4300	6503	SO:0001583	missense	AB111893	CCDS1373.1	1q31.1	2013-09-18	2013-09-18	2013-09-18	ENSG00000162670	ENSG00000162670		22393	protein-coding gene	gene with protein product			"""family with sequence similarity 5, member C"""	FAM5C	16018821, 15193423	Standard	NM_199051	Approved	DBCCR1L, DBCCR1L1	uc001gse.1	Q76B58	OTTHUMG00000035533	ENST00000367462.3:c.2048T>C	1.37:g.190067401A>G	ENSP00000356432:p.Leu683Pro	B3KVP1|B7Z260|O95726|Q2M330	ENST00000367462.3	37	CCDS1373.1	.	.	.	.	.	.	.	.	.	.	A	14.39	2.521122	0.44866	.	.	ENSG00000162670	ENST00000367462;ENST00000534846	T;T	0.21734	2.24;1.99	5.62	4.48	0.54585	.	0.082989	0.49916	D	0.000129	T	0.29321	0.0730	M	0.70275	2.135	0.80722	D	1	P;P	0.41848	0.763;0.651	P;B	0.44359	0.447;0.174	T	0.02721	-1.1119	10	0.49607	T	0.09	.	10.9682	0.47424	0.8428:0.1572:0.0:0.0	.	581;683	B7Z260;Q76B58	.;FAM5C_HUMAN	P	683;581	ENSP00000356432:L683P;ENSP00000438022:L581P	ENSP00000356432:L683P	L	-	2	0	FAM5C	188334024	1.000000	0.71417	0.996000	0.52242	0.998000	0.95712	9.237000	0.95368	0.932000	0.37266	0.528000	0.53228	CTG	BRINP3-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000086278.1		-8.765922	0	-5	93	0	0	1	0	NM_199051	4	7.044462	71	0.053333
TRPM7	54822	broad.mit.edu	hg19	15	50866914	50866914	+	Missense_Mutation	SNP	T	T	A			TCGA-WC-A87W-01A-11D-A39W-08	TCGA-WC-A87W-10A-01D-A39Z-08							Unknown	Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b97d5cc-c7d2-4d27-87cb-4c5090079458	addacac8-7364-409d-adce-53703cafaea2	g.chr15:50866914T>A	ENST00000313478.7	-	35	5303	c.5022A>T	c.(5020-5022)gaA>gaT	p.E1674D	TRPM7_ENST00000560955.1_Missense_Mutation_p.E1673D|TRPM7_ENST00000561443.1_5'UTR	NM_017672.4	NP_060142.3	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel, subfamily M, member 7	1674	Alpha-type protein kinase.	cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity	breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(17)|lung(13)|ovary(4)|pancreas(1)|skin(4)|stomach(3)	52				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)	GTTGTTGAATTTCCTATAAAA	0.303	0	126.0	120.0	122.0	15	50866914	1810	4071	5881	SO:0001583	missense	AF346629	CCDS42035.1, CCDS73725.1	15q21	2011-12-14				ENSG00000092439	"""Voltage-gated ion channels / Transient receptor potential cation channels"""	17994	protein-coding gene	gene with protein product		605692			11161216, 11385574, 16382100	Standard	XM_005254486	Approved	CHAK1, LTRPC7, TRP-PLIK	uc001zyt.4	Q96QT4		ENST00000313478.7:c.5022A>T	15.37:g.50866914T>A	ENSP00000320239:p.Glu1674Asp	Q6ZMF5|Q86VJ4|Q8NBW2|Q9BXB2|Q9NXQ2	ENST00000313478.7	37	CCDS42035.1	.	.	.	.	.	.	.	.	.	.	T	23.9	4.472146	0.84533	.	.	ENSG00000092439	ENST00000313478	T	0.06371	3.31	5.25	5.25	0.73442	MHCK/EF2 kinase (3);Protein kinase-like domain (1);	0.000000	0.85682	D	0.000000	T	0.17408	0.0418	L	0.36672	1.1	0.58432	D	0.999995	D	0.89917	1.0	D	0.87578	0.998	T	0.00657	-1.1623	10	0.87932	D	0	-26.0928	15.3214	0.74124	0.0:0.0:0.0:1.0	.	1674	Q96QT4	TRPM7_HUMAN	D	1674	ENSP00000320239:E1674D	ENSP00000320239:E1674D	E	-	3	2	TRPM7	48654206	1.000000	0.71417	1.000000	0.80357	0.955000	0.61496	3.362000	0.52314	2.191000	0.70037	0.528000	0.53228	GAA	TRPM7-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000418604.1		64.602695	0	1	90	0	0	1	0	NM_017672	23	66.299791	46	0.333333
GNA11	2767	broad.mit.edu	hg19	19	3118942	3118942	+	Missense_Mutation	SNP	A	A	T			TCGA-WC-A87W-01A-11D-A39W-08	TCGA-WC-A87W-10A-01D-A39Z-08							Unknown	Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b97d5cc-c7d2-4d27-87cb-4c5090079458	addacac8-7364-409d-adce-53703cafaea2	g.chr19:3118942A>T	ENST00000078429.4	+	5	868	c.626A>T	c.(625-627)cAg>cTg	p.Q209L	GNA11_ENST00000586180.1_3'UTR|AC005262.3_ENST00000587701.1_RNA	NM_002067.2	NP_002058.2	P29992	GNA11_HUMAN	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	209		activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation|regulation of action potential	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity	endometrium(2)|eye(132)|kidney(1)|large_intestine(2)|lung(1)|meninges(5)|ovary(1)|prostate(1)|skin(16)	161		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.79e-05)|OV - Ovarian serous cystadenocarcinoma(105;2.68e-113)|Epithelial(107;1.22e-111)|all cancers(105;5.78e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00141)|STAD - Stomach adenocarcinoma(1328;0.181)	GTGGGGGGCCAGCGGTCGGAG	0.612	82	104.0	89.0	94.0	19	3118942	2203	4300	6503	SO:0001583	missense	AF493900	CCDS12103.1	19p13.3	2014-02-04			ENSG00000088256	ENSG00000088256		4379	protein-coding gene	gene with protein product		139313	"""hypocalciuric hypercalcemia 2"""	HHC2	1302014, 23802516	Standard	NM_002067	Approved	FBH, FBH2, FHH2	uc002lxd.3	P29992	OTTHUMG00000180631	ENST00000078429.4:c.626A>T	19.37:g.3118942A>T	ENSP00000078429:p.Gln209Leu	O15109|Q14350|Q6IB00	ENST00000078429.4	37	CCDS12103.1	.	.	.	.	.	.	.	.	.	.	.	15.05	2.718086	0.48622	.	.	ENSG00000088256	ENST00000078429	D	0.91237	-2.81	3.26	3.26	0.37387	.	0.000000	0.64402	U	0.000006	D	0.96950	0.9004	H	0.99357	4.53	0.80722	D	1	D	0.59767	0.986	D	0.68483	0.958	D	0.96823	0.9605	10	0.87932	D	0	.	10.7338	0.46113	1.0:0.0:0.0:0.0	.	209	P29992	GNA11_HUMAN	L	209	ENSP00000078429:Q209L	ENSP00000078429:Q209L	Q	+	2	0	GNA11	3069942	1.000000	0.71417	0.438000	0.26821	0.027000	0.11550	9.104000	0.94239	1.256000	0.44068	0.379000	0.24179	CAG	GNA11-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000452261.2		71.362376	0	-3	78	0	0	1	0	NM_002067	25	71.948661	38	0.396825
MAGED1	9500	broad.mit.edu	hg19	X	51640905	51640905	+	Silent	SNP	A	A	G			TCGA-WC-A87W-01A-11D-A39W-08	TCGA-WC-A87W-10A-01D-A39Z-08							Unknown	Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b97d5cc-c7d2-4d27-87cb-4c5090079458	addacac8-7364-409d-adce-53703cafaea2	g.chrX:51640905A>G	ENST00000375695.2	+	8	1902	c.1749A>G	c.(1747-1749)caA>caG	p.Q583Q	MAGED1_ENST00000494718.1_3'UTR|MAGED1_ENST00000375722.1_Silent_p.Q527Q|MAGED1_ENST00000375772.3_Silent_p.Q527Q|MAGED1_ENST00000326587.7_Silent_p.Q527Q	NM_001005333.1	NP_001005333.1	Q9Y5V3	MAGD1_HUMAN	melanoma antigen family D, 1	527	MAGE.	apoptosis|induction of apoptosis by extracellular signals|negative regulation of epithelial cell proliferation|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|plasma membrane|protein complex	protein binding	breast(1)|endometrium(4)|large_intestine(10)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	32	Ovarian(276;0.236)				TTGGGATTCAACTGAAAGAAA	0.443	0	52.0	46.0	48.0	X	51640905	2203	4299	6502	SO:0001819	synonymous_variant	AF124440	CCDS14337.1, CCDS35279.1	Xp11.23	2008-08-01			ENSG00000179222	ENSG00000179222		6813	protein-coding gene	gene with protein product		300224			10409427	Standard	NM_006986	Approved	NRAGE, DLXIN-1	uc004dpn.3	Q9Y5V3	OTTHUMG00000021540	ENST00000375722.1:c.1581A>G	X.37:g.51640905A>G		Q5VSH6|Q8IZ84|Q8WY92|Q9H352|Q9HBT4|Q9UF36	ENST00000375722.1	37	CCDS14337.1																																																																																			MAGED1-005	KNOWN	alternative_5_UTR|basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000056593.1		29.371404	0	-8	23	0	0	1	0	NM_001005332	9	29.530145	13	0.409091
ITGA8	8516	broad.mit.edu	hg19	10	15701035	15701035	+	Missense_Mutation	SNP	G	G	A	rs148965352	byFrequency	TCGA-WC-A87W-01A-11D-A39W-08	TCGA-WC-A87W-10A-01D-A39Z-08							Unknown	Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b97d5cc-c7d2-4d27-87cb-4c5090079458	addacac8-7364-409d-adce-53703cafaea2	g.chr10:15701035G>A	ENST00000378076.3	-	10	1264	c.911C>T	c.(910-912)aCg>aTg	p.T304M		NM_003638.1	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8	304		cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity	NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96					CGTCATATCCGTAGAGTTAAT	0.318	0	52.0	54.0	53.0	10	15701035	2203	4298	6501	SO:0001583	missense	L36531	CCDS31155.1	10p13	2010-03-23			ENSG00000077943	ENSG00000077943	"""Integrins"""	6144	protein-coding gene	gene with protein product		604063			7768999	Standard	XM_005252633	Approved		uc001ioc.1	P53708	OTTHUMG00000017733	ENST00000378076.3:c.911C>T	10.37:g.15701035G>A	ENSP00000367316:p.Thr304Met	B0YJ31|Q5VX94	ENST00000378076.3	37	CCDS31155.1	1	4.578754578754579E-4	0	0.0	0	0.0	0	0.0	1	0.0013192612137203166	G	19.50	3.839816	0.71488	4.54E-4	0.001396	ENSG00000077943	ENST00000378076;ENST00000538044	T	0.24350	1.86	5.59	5.59	0.84812	.	0.139474	0.64402	D	0.000005	T	0.45756	0.1358	L	0.55834	1.745	0.53688	D	0.999976	D;D	0.89917	1.0;1.0	D;P	0.67103	0.949;0.891	T	0.22626	-1.0211	10	0.49607	T	0.09	.	16.2993	0.82801	0.0:0.0:1.0:0.0	.	289;304	F5H818;P53708	.;ITA8_HUMAN	M	304;289	ENSP00000367316:T304M	ENSP00000367316:T304M	T	-	2	0	ITGA8	15741041	1.000000	0.71417	1.000000	0.80357	0.987000	0.75469	6.825000	0.75293	2.634000	0.89283	0.563000	0.77884	ACG	ITGA8-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000046987.1		-2.210950	0	10	89	0	0	1	0	NM_003638	3	6.547389	42	0.066667
NBEAL2	23218	broad.mit.edu	hg19	3	47033435	47033435	+	Splice_Site	SNP	A	A	T			TCGA-WC-A87W-01A-11D-A39W-08	TCGA-WC-A87W-10A-01D-A39Z-08							Unknown	Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b97d5cc-c7d2-4d27-87cb-4c5090079458	addacac8-7364-409d-adce-53703cafaea2	g.chr3:47033435A>T	ENST00000450053.3	+	9	1210	c.1031A>T	c.(1030-1032)aAg>aTg	p.K344M	NBEAL2_ENST00000383740.2_5'UTR|NBEAL2_ENST00000292309.5_Splice_Site_p.K344M	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	344				binding	NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)	CAGAACAGCAAGGTGGGTAGG	0.592	0	42.0	40.0	40.0	3	47033435	2052	4202	6254	SO:0001630	splice_region_variant	AB011112	CCDS46817.1	3p21.31	2014-09-17			ENSG00000160796	ENSG00000160796	"""WD repeat domain containing"""	31928	protein-coding gene	gene with protein product		614169				Standard	NM_015175	Approved	KIAA0540	uc003cqp.3	Q6ZNJ1	OTTHUMG00000156497	ENST00000450053.3:c.1032+1A>T	3.37:g.47033435A>T		O60288|Q6P994|Q6UX91|Q8NAC9	ENST00000450053.3	37	CCDS46817.1	.	.	.	.	.	.	.	.	.	.	A	24.2	4.506466	0.85282	.	.	ENSG00000160796	ENST00000292309;ENST00000450053;ENST00000296147	T;T	0.61980	0.06;0.06	4.13	4.13	0.48395	Armadillo-type fold (1);	.	.	.	.	T	0.74816	0.3766	M	0.66939	2.045	0.80722	D	1	D;D	0.89917	1.0;0.994	D;P	0.69479	0.964;0.733	T	0.78135	-0.2322	9	0.87932	D	0	.	12.4731	0.55797	1.0:0.0:0.0:0.0	.	337;344	Q6ZNJ1-4;Q6ZNJ1	.;NBEL2_HUMAN	M	344;344;337	ENSP00000292309:K344M;ENSP00000415034:K344M	ENSP00000292309:K344M	K	+	2	0	NBEAL2	47008439	1.000000	0.71417	1.000000	0.80357	0.943000	0.58893	6.894000	0.75655	1.723000	0.51488	0.379000	0.24179	AAG	NBEAL2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000344363.3		12.499512	0	-7	13	0	0	1	0	XM_291064	4	12.499512	4	0.500000
PCGF2	7703	broad.mit.edu	hg19	17	36891521	36891521	+	Frame_Shift_Del	DEL	C	C	-			TCGA-WC-A87W-01A-11D-A39W-08	TCGA-WC-A87W-10A-01D-A39Z-08							Unknown	Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b97d5cc-c7d2-4d27-87cb-4c5090079458	addacac8-7364-409d-adce-53703cafaea2	g.chr17:36891521delC	ENST00000580830.1	-	12	1691	c.990delG	c.(988-990)gggfs	p.G330fs	PCGF2_ENST00000581345.1_Frame_Shift_Del_p.G330fs|PCGF2_ENST00000585100.1_3'UTR|PCGF2_ENST00000360797.2_Frame_Shift_Del_p.G330fs|PCGF2_ENST00000579882.1_3'UTR|PCGF2_ENST00000578109.1_3'UTR			P35227	PCGF2_HUMAN	polycomb group ring finger 2	330	Pro/Ser-rich.	negative regulation of transcription from RNA polymerase II promoter	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	10	Breast(7;9.07e-22)				TCATCTTGCGCCCCCTGCTGG	0.627	0	17.0	10.0	13.0	17	36891521	2167	4257	6424	SO:0001589	frameshift_variant	D13969	CCDS32638.1	17q12	2013-01-09	2005-01-17	2005-01-19		ENSG00000277258	"""RING-type (C3HC4) zinc fingers"", ""Polycomb group ring fingers"""	12929	protein-coding gene	gene with protein product		600346	"""ring finger protein 110"""	ZNF144, RNF110	8325509	Standard	NM_007144	Approved	MEL-18	uc002hqp.1	P35227		ENST00000580830.1:c.990delG	17.37:g.36891521delC	ENSP00000461961:p.Gly330fs	A6NGD8	ENST00000580830.1	37	CCDS32638.1																																																																																			PCGF2-002	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000442246.2	.	.		4	6					NM_007144	2		4	0.33
PPP1R15A	23645	broad.mit.edu	hg19	19	49377681	49377682	+	Frame_Shift_Ins	INS	-	-	G			TCGA-WC-A87W-01A-11D-A39W-08	TCGA-WC-A87W-10A-01D-A39Z-08							Unknown	Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b97d5cc-c7d2-4d27-87cb-4c5090079458	addacac8-7364-409d-adce-53703cafaea2	g.chr19:49377681_49377682insG	ENST00000200453.5	+	2	1460_1461	c.1191_1192insG	c.(1192-1194)gagfs	p.E398fs		NM_014330.3	NP_055145.3	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	398	4 X 34 AA approximate repeats.|Glu-rich.|Interaction with SMAD7.	apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding	breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(8)|skin(2)|urinary_tract(1)	23		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)	GAGAGGACACAGAGGAGGAGGA	0.530	0									SO:0001589	frameshift_variant	U83981	CCDS12738.1	19q13.2	2012-04-17	2011-10-04		ENSG00000087074	ENSG00000087074	"""Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits"""	14375	protein-coding gene	gene with protein product	"""growth arrest and DNA-damage-inducible 34"""	611048	"""protein phosphatase 1, regulatory (inhibitor) subunit 15A"""		9153226, 9413226	Standard	NM_014330	Approved	GADD34	uc002pky.4	O75807		ENST00000200453.5:c.1192dupG	19.37:g.49377682_49377682dupG	ENSP00000200453:p.Glu398fs	B4DKQ3|Q6IA96|Q9NVU6	ENST00000200453.5	37	CCDS12738.1																																																																																			PPP1R15A-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000466226.1	.	.		6	130					NM_014330	38		54	0.41
PTPRG	5793	broad.mit.edu	hg19	3	61548042	61548054	+	Splice_Site	DEL	CCCCGGTGAGTGC	CCCCGGTGAGTGC	-	rs2365955		TCGA-WC-A87W-01A-11D-A39W-08	TCGA-WC-A87W-10A-01D-A39Z-08							Unknown	Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b97d5cc-c7d2-4d27-87cb-4c5090079458	addacac8-7364-409d-adce-53703cafaea2	g.chr3:61548042_61548054delCCCCGGTGAGTGC	ENST00000474889.1	+	1	458_462	c.81_85delCCCCGGTGAGTGC	c.(79-87)ttccccggt>ttgt	p.FPG27fs	PTPRG_ENST00000295874.10_Splice_Site_p.FPG27fs|PTPRG_ENST00000495879.1_3'UTR	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	27		transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity	NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)	TCGTGTGCTTCCCCGGTGAGTGCCGGCCGCCGA	0.648	1									SO:0001630	splice_region_variant	L09247	CCDS2895.1	3p21-p14	2013-02-11			ENSG00000144724	ENSG00000144724	"""Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like"", ""Fibronectin type III domain containing"""	9671	protein-coding gene	gene with protein product		176886		PTPG	1711217	Standard	NM_002841	Approved	RPTPG	uc003dlb.3	P23470	OTTHUMG00000158660	ENST00000474889.1:c.85+1CCCCGGTGAGTGC>-	3.37:g.61548042_61548054delCCCCGGTGAGTGC		B2RU12|B7ZLX5|Q15623|Q59EE0|Q68DU5	ENST00000474889.1	37	CCDS2895.1																																																																																			PTPRG-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000351674.1	.	.		-14	179					NM_002841	11		144	0.07
LZTS3	0	broad.mit.edu	hg19	20	3145615	3145615	+	Frame_Shift_Del	DEL	C	C	-			TCGA-WC-A87W-01A-11D-A39W-08	TCGA-WC-A87W-10A-01D-A39Z-08							Unknown	Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b97d5cc-c7d2-4d27-87cb-4c5090079458	addacac8-7364-409d-adce-53703cafaea2	g.chr20:3145615delC	ENST00000329152.3	-	3	2904	c.1507delG	c.(1507-1509)gccfs	p.A503fs	LZTS3_ENST00000360342.3_Frame_Shift_Del_p.A457fs|LZTS3_ENST00000337576.5_Frame_Shift_Del_p.A457fs																	TCCAGGCTGGCCTGCTTGCTG	0.716	0	6.0	6.0	6.0	20	3145615	2119	4145	6264	SO:0001589	frameshift_variant																									ENST00000329152.3:c.1507delG	20.37:g.3145615delC	ENSP00000332123:p.Ala503fs	A2A2Q7|D3DVX6|Q8IXX8	ENST00000329152.3	37	CCDS13049.1																																																																																			LZTS3-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000077715.2	.	.		-2	6						2		4	0.33