Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GPRASP2	114928	broad.mit.edu	37	X	101972267	101972267	+	Missense_Mutation	SNP	G	G	T			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chrX:101972267G>T	ENST00000543253.1	+	5	3389	c.2470G>T	c.(2470-2472)Gcc>Tcc	p.A824S	GPRASP2_ENST00000535209.1_Missense_Mutation_p.A824S|GPRASP2_ENST00000332262.5_Missense_Mutation_p.A824S	NM_001004051.3|NM_001184874.2|NM_001184876.2	NP_001004051.1|NP_001171803.1|NP_001171805.1			G protein-coupled receptor associated sorting protein 2											breast(3)|endometrium(5)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	30						GCAACTACAAGCCCAAATAGA	0.403000													4	73					1.024e-07	1.09137e-07	1	1	0
PKDREJ	10343	broad.mit.edu	37	22	46654307	46654307	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr22:46654307G>A	ENST00000253255.5	-	1	4912	c.4913C>T	c.(4912-4914)aCg>aTg	p.T1638M		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	1638					acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		GGGTTTATTCGTTCTGAAGCC	0.393000													9	37					0	0	1	0	0
SPOP	8405	broad.mit.edu	37	17	47696405	47696405	+	Missense_Mutation	SNP	C	C	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr17:47696405C>A	ENST00000393331.3	-	7	888	c.418G>T	c.(418-420)Gat>Tat	p.D140Y	SPOP_ENST00000504102.1_Missense_Mutation_p.D140Y|SPOP_ENST00000503676.1_Missense_Mutation_p.D140Y|SPOP_ENST00000393328.2_Missense_Mutation_p.D140Y|SPOP_ENST00000347630.2_Missense_Mutation_p.D140Y	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	140	MATH.|Required for nuclear localization.				mRNA processing	nucleus	protein binding	p.D140N(1)		endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						AAAAGAAAATCTCTACGGATG	0.463000										Prostate(2;0.17)			108	9					1.85599e-38	2.14764e-38	1	1	0
CEP128	145508	broad.mit.edu	37	14	81244369	81244369	+	Missense_Mutation	SNP	T	T	C			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr14:81244369T>C	ENST00000555265.1	-	16	2608	c.2233A>G	c.(2233-2235)Aat>Gat	p.N745D	CEP128_ENST00000281129.3_Missense_Mutation_p.N745D			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	745						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						TTAGCCATATTCTTCTCTTCT	0.363000													25	24					0	0	1	0	0
GIMAP1	170575	broad.mit.edu	37	7	150417642	150417642	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr7:150417642C>T	ENST00000307194.5	+	3	690	c.550C>T	c.(550-552)Cgg>Tgg	p.R184W		NM_130759.3	NP_570115.1			GTPase, IMAP family member 1											NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GTGCGGGGGCCGGGTCTGTGC	0.677000													19	44					0	0	1	0	0
TOX	9760	broad.mit.edu	37	8	59851928	59851928	+	Missense_Mutation	SNP	A	A	G			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr8:59851928A>G	ENST00000361421.1	-	3	564	c.344T>C	c.(343-345)cTc>cCc	p.L115P		NM_014729.2	NP_055544.1	O94900	TOX_HUMAN	thymocyte selection-associated high mobility group box	115						nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(13)|prostate(1)|skin(2)|stomach(1)	33		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				GATTTCAGGGAGGTCCATGTT	0.478000													8	141					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227896894	227896894	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr2:227896894G>A	ENST00000396625.3	-	39	3883	c.3676C>T	c.(3676-3678)Cgt>Tgt	p.R1226C	COL4A4_ENST00000329662.7_Missense_Mutation_p.R1226C	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1226	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TTCTTTCCACGAGGACCTGGA	0.527000													38	31					0	0	1	0	0
TGM5	9333	broad.mit.edu	37	15	43531185	43531185	+	Missense_Mutation	SNP	G	G	A	rs141830093		TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr15:43531185G>A	ENST00000220420.5	-	9	1182	c.1175C>T	c.(1174-1176)aCg>aTg	p.T392M	TGM5_ENST00000349114.4_Missense_Mutation_p.T310M	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	392					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	CACAAAGGGCGTGTCATAGTT	0.557000													4	40					0	0	1	0	0
IGFBPL1	347252	broad.mit.edu	37	9	38411522	38411522	+	Nonsense_Mutation	SNP	C	C	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr9:38411522C>A	ENST00000377694.1	-	4	734	c.712G>T	c.(712-714)Gag>Tag	p.E238*		NM_001007563.1	NP_001007564.1	Q8WX77	IBPL1_HUMAN	insulin-like growth factor binding protein-like 1	238	Ig-like C2-type.				regulation of cell growth	extracellular region	insulin-like growth factor binding			endometrium(1)|lung(2)|upper_aerodigestive_tract(1)	4				GBM - Glioblastoma multiforme(29;0.0437)|Lung(182;0.116)		TACACACCCTCATCCTCCTTT	0.448000													11	17					1.08611e-07	1.14253e-07	1	1	0
CST2	1470	broad.mit.edu	37	20	23807168	23807168	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr20:23807168C>T	ENST00000304725.2	-	1	200	c.130G>A	c.(130-132)Gta>Ata	p.V44I		NM_001322.2	NP_001313.1	P09228	CYTT_HUMAN	cystatin SA	44						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)|cervix(1)|large_intestine(1)|liver(1)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	10						GCACGCTGTACCCGCTCATCA	0.592000													29	37					0	0	1	0	0
GFOD1	54438	broad.mit.edu	37	6	13365867	13365867	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr6:13365867C>T	ENST00000379287.3	-	2	945	c.281G>A	c.(280-282)cGc>cAc	p.R94H	GFOD1_ENST00000379284.1_5'UTR	NM_018988.3	NP_061861.1	Q9NXC2	GFOD1_HUMAN	glucose-fructose oxidoreductase domain containing 1	94						extracellular region	binding|oxidoreductase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)	18	Breast(50;0.0296)|Ovarian(93;0.0454)	all_hematologic(90;0.135)	Epithelial(50;0.0348)|BRCA - Breast invasive adenocarcinoma(129;0.1)|all cancers(50;0.108)			CGTGGCCGTGCGGTCGCAGAT	0.657000													32	74					0	0	1	0	0
PKNOX2	63876	broad.mit.edu	37	11	125301240	125301240	+	Silent	SNP	G	G	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr11:125301240G>A	ENST00000298282.9	+	13	1642	c.1371G>A	c.(1369-1371)acG>acA	p.T457T	PKNOX2_ENST00000530517.1_3'UTR|PKNOX2_ENST00000542175.1_Silent_p.T393T	NM_022062.2	NP_071345.2	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	457						nucleus	sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(14)|ovary(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	29		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		AGCTGCAGACGACAAATGTCA	0.582000													28	20					0	0	1	0	0
ALAS2	212	broad.mit.edu	37	X	55042071	55042071	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chrX:55042071C>T	ENST00000330807.5	-	8	1245	c.1108G>A	c.(1108-1110)Gct>Act	p.A370T	ALAS2_ENST00000335854.4_Missense_Mutation_p.A333T|ALAS2_ENST00000396198.3_Missense_Mutation_p.A357T|ALAS2_ENST00000498636.1_5'UTR	NM_000032.4	NP_000023.2	P22557	HEM0_HUMAN	aminolevulinate, delta-, synthase 2	370					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			central_nervous_system(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(2)|skin(1)	17					Glycine(DB00145)	CCAATCCCAGCGCCCCGGGAC	0.527000													27	53					0	0	1	0	0
FAM24B	196792	broad.mit.edu	37	10	124608784	124608784	+	Silent	SNP	G	G	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr10:124608784G>A	ENST00000368898.3	-	4	554	c.264C>T	c.(262-264)tgC>tgT	p.C88C	FAM24B_ENST00000462859.1_5'UTR|CUZD1_ENST00000368904.1_5'UTR|FAM24B_ENST00000368896.1_Silent_p.C88C|CUZD1_ENST00000545804.1_Intron	NM_152644.2	NP_689857.2	Q8N5W8	FA24B_HUMAN	family with sequence similarity 24, member B	88						extracellular region				endometrium(1)|kidney(1)|large_intestine(1)|lung(1)	4		all_neural(114;0.0765)|Lung NSC(174;0.163)|all_lung(145;0.205)		Colorectal(40;0.136)|COAD - Colon adenocarcinoma(40;0.141)		CATTTATGTCGCAACAGCAAG	0.448000													14	41					0	0	1	0	0
AMER2	219287	broad.mit.edu	37	13	25744725	25744725	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr13:25744725C>T	ENST00000515384.1	-	1	1700	c.1033G>A	c.(1033-1035)Gcc>Acc	p.A345T	AMER2_ENST00000381853.3_Intron|AMER2_ENST00000357816.2_Intron					APC membrane recruitment protein 2																		GGGTCTggggcggcgggcgcc	0.627000													8	18					0	0	1	0	0
MT-ND4	4538	broad.mit.edu	37	MT	11120	11120	+	Missense_Mutation	SNP	T	T	C			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chrM:11120T>C	ENST00000361381.2	+	1	361	c.361T>C	c.(361-363)Ttc>Ctc	p.121_121insL						mitochondrially encoded NADH dehydrogenase 4											breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|prostate(1)	13						TATTTTATATCTTCTTCGAAA	0.418000													28	112					0	0	1	0	0
HOOK3	84376	broad.mit.edu	37	8	42761327	42761327	+	Missense_Mutation	SNP	T	T	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr8:42761327T>A	ENST00000307602.4	+	2	269	c.69T>A	c.(67-69)ttT>ttA	p.F23L		NM_032410.3	NP_115786.1	Q86VS8	HOOK3_HUMAN	hook microtubule-tethering protein 3	23	Sufficient for interaction with microtubules.				cytoplasmic microtubule organization|early endosome to late endosome transport|endosome organization|endosome to lysosome transport|Golgi localization|interkinetic nuclear migration|lysosome organization|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome|protein transport	cis-Golgi network|FHF complex|microtubule|pericentriolar material	identical protein binding|microtubule binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	31	Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.000105)|Lung NSC(58;0.000419)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.048)|LUSC - Lung squamous cell carcinoma(45;0.114)			TCCAGACATTTAATGTGGATG	0.398000			T	RET	papillary thyroid								8	290					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145293414	145293414	+	Silent	SNP	A	A	G			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr1:145293414A>G	ENST00000342960.5	+	1	44	c.9A>G	c.(7-9)gtA>gtG	p.V3V	RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Silent_p.V3V	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GCATGGTGGTATCAGCCGGCC	0.493000													38	921					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144941352	144941352	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr8:144941352G>A	ENST00000525985.1	-	2	6141	c.6070C>T	c.(6070-6072)Cgg>Tgg	p.R2024W				P58107	EPIPL_HUMAN	epiplakin 1	2024						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGTGGGAGCCGGTGGTGGTGC	0.612000													6	100					0	0	1	0	0
MUC3A	4584	broad.mit.edu	37	7	100551690	100551690	+	Silent	SNP	T	T	G			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr7:100551690T>G	ENST00000319509.7	+	1	441	c.441T>G	c.(439-441)ccT>ccG	p.P147P						mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						AAACATCTCCTGCACCTACTA	0.493000													12	392					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19741121	19741121	+	Nonsense_Mutation	SNP	G	G	C			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr19:19741121G>C	ENST00000203556.4	-	21	2701	c.2564C>G	c.(2563-2565)tCa>tGa	p.S855*	GMIP_ENST00000445806.2_Nonsense_Mutation_p.S826*|GMIP_ENST00000587238.1_Nonsense_Mutation_p.S829*	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	855					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						CCCCAGGAGTGAGTCCTCTGG	0.607000													18	69					0	0	1	0	0
LINC00264	0	broad.mit.edu	37	10	26880266	26880266	+	RNA	SNP	G	G	A	rs138111133	by1000genomes	TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr10:26880266G>A	ENST00000412114.1	+	0	501					NR_026793.1																						ACCAAGCCCAGTGGACAGATG	0.443000													5	64					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53674334	53674334	+	Missense_Mutation	SNP	G	G	C			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chrX:53674334G>C	ENST00000342160.3	-	5	785	c.328C>G	c.(328-330)Cgg>Ggg	p.R110G	HUWE1_ENST00000262854.6_Missense_Mutation_p.R110G|HUWE1_ENST00000218328.8_Missense_Mutation_p.R110G			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	110					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						TACAGATGCCGGGAAAAGCTG	0.438000													25	26					0	0	1	0	0
SULT1C3	442038	broad.mit.edu	37	2	108868909	108868909	+	Silent	SNP	C	C	T			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr2:108868909C>T	ENST00000329106.2	+	2	261	c.261C>T	c.(259-261)caC>caT	p.H87H	SULT1C3_ENST00000376700.1_Silent_p.H87H	NM_001008743.1	NP_001008743.1	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member 3	87						cytoplasm	alcohol sulfotransferase activity			breast(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(4)	16						TAGATAGACACGCTTTCCTTG	0.373000													12	25					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136589310	136589310	+	Missense_Mutation	SNP	C	C	G			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr6:136589310C>G	ENST00000531224.1	-	10	2639	c.2387G>C	c.(2386-2388)cGa>cCa	p.R796P	BCLAF1_ENST00000031135.9_Missense_Mutation_p.R14P|BCLAF1_ENST00000527759.1_Missense_Mutation_p.R794P|BCLAF1_ENST00000353331.4_Missense_Mutation_p.R794P|BCLAF1_ENST00000392348.2_Missense_Mutation_p.R794P|BCLAF1_ENST00000529917.1_5'UTR|BCLAF1_ENST00000527536.1_Missense_Mutation_p.R796P|BCLAF1_ENST00000530767.1_Missense_Mutation_p.R623P	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	796					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		AAAGGTTCCTCGTGGTCGGCT	0.358000													48	77					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88963677	88963677	+	Missense_Mutation	SNP	C	C	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr7:88963677C>A	ENST00000333190.4	+	4	1990	c.1381C>A	c.(1381-1383)Ctt>Att	p.L461I		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	461						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GCCTACGGAACTTCTGCTCTT	0.423000										HNSCC(36;0.09)			17	39					1.37285e-15	1.48268e-15	1	1	0
ANXA13	312	broad.mit.edu	37	8	124693594	124693594	+	Missense_Mutation	SNP	G	G	T			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr8:124693594G>T	ENST00000262219.6	-	12	1027	c.960C>A	c.(958-960)gaC>gaA	p.D320E	ANXA13_ENST00000419625.1_Missense_Mutation_p.D279E	NM_001003954.1	NP_001003954.1	P27216	ANX13_HUMAN	annexin A13	279					cell differentiation	plasma membrane	calcium ion binding|calcium-dependent phospholipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(2)	25	Lung NSC(37;2.06e-11)|Ovarian(258;0.00579)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00288)			TCCCCTGAAGGTCCACCTGTA	0.438000													48	294					3.77016e-25	4.30117e-25	1	1	0
RPL31P11	0	broad.mit.edu	37	1	161654728	161654728	+	RNA	SNP	G	G	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr1:161654728G>A	ENST00000426558.1	-	0	314					NR_002595.1																						TCCTCATTACGTTTTCGGGAC	0.438000													20	18					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78790136	78790136	+	Missense_Mutation	SNP	T	T	C	rs62556589		TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr9:78790136T>C	ENST00000376767.3	+	14	2503	c.1991T>C	c.(1990-1992)aTg>aCg	p.M664T	PCSK5_ENST00000376752.4_Intron|PCSK5_ENST00000545128.1_Intron			Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	0	CRM (Cys-rich motif).				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						tggaatggaatgaaatggaat	0.423000													4	23					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157516848	157516848	+	Missense_Mutation	SNP	T	T	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr1:157516848T>A	ENST00000361835.3	-	3	349	c.192A>T	c.(190-192)aaA>aaT	p.K64N	FCRL5_ENST00000356953.4_Missense_Mutation_p.K64N|FCRL5_ENST00000368191.3_Intron|FCRL5_ENST00000368188.2_Missense_Mutation_p.K64N|FCRL5_ENST00000368190.3_Missense_Mutation_p.K64N|FCRL5_ENST00000368189.3_Missense_Mutation_p.K64N	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	64	Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				TTAGTATTTCTTTCCCAAGGT	0.502000													23	89					0	0	1	0	0
TNFAIP3	7128	broad.mit.edu	37	6	138200072	138200072	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr6:138200072G>A	ENST00000237289.4	+	7	1556	c.1490G>A	c.(1489-1491)cGt>cAt	p.R497H		NM_001270507.1|NM_001270508.1|NM_006290.3	NP_001257436.1|NP_001257437.1|NP_006281.1	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	497	Interaction with NAF1 (By similarity).				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(25)		breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(196)|kidney(1)|large_intestine(4)|lung(13)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	225	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		TTTTGTGAACGTTGCCACAAC	0.597000			"""D, N, F"""		"""marginal zone B-cell lymphomas, Hodgkin's lymphoma, primary mediastinal B cell lymphoma"""								8	61					0	0	1	0	0
HLA-DRA	3122	broad.mit.edu	37	6	32410986	32410986	+	Missense_Mutation	SNP	C	C	T	rs61117681		TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr6:32410986C>T	ENST00000395388.2	+	3	462	c.353C>T	c.(352-354)aCa>aTa	p.T118I	HLA-DRA_ENST00000374982.5_Intron	NM_019111.4	NP_061984.2	P01903	DRA_HUMAN	major histocompatibility complex, class II, DR alpha	118	Alpha-2.|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|Golgi apparatus|integral to plasma membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			NS(1)|breast(1)|large_intestine(6)|lung(5)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	19						ACTGTGCTCACAAACAGCCCT	0.512000									T-cell Lymphoma, (Cutaneous) , Familial Clustering of;Kaposi Sarcoma, Familial Clustering of				7	57					0	0	1	0	0
KIF26B	55083	broad.mit.edu	37	1	245851417	245851417	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr1:245851417G>A	ENST00000366518.4	+	9	4093	c.3989G>A	c.(3988-3990)gGc>gAc	p.G1330D	KIF26B_ENST00000407071.2_Missense_Mutation_p.G1711D			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1711					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			AGGAGCCTGGGCCGCAGCGCC	0.746000													8	6					0	0	1	0	0
C11orf1	64776	broad.mit.edu	37	11	111753232	111753232	+	Silent	SNP	T	T	C			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr11:111753232T>C	ENST00000260276.3	+	2	523	c.186T>C	c.(184-186)aaT>aaC	p.N62N	C11orf1_ENST00000530214.1_Silent_p.N62N|C11orf1_ENST00000528125.1_Silent_p.N16N|C11orf1_ENST00000529270.1_Silent_p.N102N	NM_022761.2	NP_073598.1	Q9H5F2	CK001_HUMAN	chromosome 11 open reading frame 1	62						nucleus				kidney(2)|lung(3)	5		all_cancers(61;1.26e-15)|all_epithelial(67;9.52e-10)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|Medulloblastoma(222;0.0228)|all_neural(223;0.0281)		all cancers(92;6.28e-09)|Epithelial(105;4.11e-08)|OV - Ovarian serous cystadenocarcinoma(223;1.52e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)		CTAATGAGAATACCTATTCAA	0.463000													10	27					0	0	1	0	0
ABCC2	1244	broad.mit.edu	37	10	101559103	101559103	+	Missense_Mutation	SNP	C	C	T	rs149854486		TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr10:101559103C>T	ENST00000370449.4	+	8	1120	c.1007C>T	c.(1006-1008)aCg>aTg	p.T336M		NM_000392.3	NP_000383.1	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	336	ABC transmembrane type-1 1.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GACATCTTCACGTTTGTGAGT	0.473000													15	183					0	0	1	0	0
ZMAT4	79698	broad.mit.edu	37	8	40438702	40438702	+	Missense_Mutation	SNP	C	C	G			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr8:40438702C>G	ENST00000297737.6	-	6	802	c.656G>C	c.(655-657)gGa>gCa	p.G219A	ZMAT4_ENST00000315769.7_Missense_Mutation_p.G143A	NM_024645.2	NP_078921.1	Q9H898	ZMAT4_HUMAN	zinc finger, matrin-type 4	219						nucleus	DNA binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			GTGTTTAGATCCTTTCAGATG	0.408000													227	31					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21805153	21805153	+	Silent	SNP	G	G	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr7:21805153G>A	ENST00000328843.6	+	56	9100	c.9069G>A	c.(9067-9069)caG>caA	p.Q3023Q	DNAH11_ENST00000409508.3_Silent_p.Q3016Q			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3023	AAA 4 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						CGTGGCCGCAGGAGGCTCTGG	0.542000									Kartagener syndrome				15	41					0	0	1	0	0
GTF2H1	2965	broad.mit.edu	37	11	18369434	18369434	+	Missense_Mutation	SNP	G	G	C			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr11:18369434G>C	ENST00000265963.4	+	9	1181	c.1021G>C	c.(1021-1023)Gat>Cat	p.D341H	GTF2H1_ENST00000534641.1_Missense_Mutation_p.D225H|GTF2H1_ENST00000524753.4_Missense_Mutation_p.D137H|GTF2H1_ENST00000530496.2_Missense_Mutation_p.D29H|GTF2H1_ENST00000453096.2_Missense_Mutation_p.D341H	NM_005316.3	NP_005307.1	P32780	TF2H1_HUMAN	general transcription factor IIH, polypeptide 1, 62kDa	341					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	protein binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	20						AAATTCCGGAGATGCAGACTG	0.393000								Nucleotide excision repair (NER)					6	44					0	0	1	0	0
U2AF1	7307	broad.mit.edu	37	21	44524456	44524456	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr21:44524456G>A	ENST00000291552.4	-	2	193	c.101C>T	c.(100-102)tCt>tTt	p.S34F	U2AF1_ENST00000459639.1_5'UTR|U2AF1_ENST00000486519.1_5'UTR|U2AF1_ENST00000380276.2_Missense_Mutation_p.S34F|U2AF1_ENST00000398137.1_5'UTR	NM_006758.2	NP_006749.1	Q01081	U2AF1_HUMAN	U2 small nuclear RNA auxiliary factor 1	34					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	Cajal body|catalytic step 2 spliceosome|nuclear speck	nucleotide binding|RNA binding|zinc ion binding	p.S34F(45)|p.S34Y(12)		breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(111)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	126						GTGCAACCGAGAGCACCTGTC	0.358000			Mis		"""CLL, MDS"""								13	26					0	0	1	0	0
UBXN10	127733	broad.mit.edu	37	1	20517119	20517119	+	Missense_Mutation	SNP	T	T	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr1:20517119T>A	ENST00000375099.3	+	2	149	c.65T>A	c.(64-66)gTt>gAt	p.V22D		NM_152376.3	NP_689589.1	Q96LJ8	UBX10_HUMAN	UBX domain protein 10	22										endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|ovary(2)|skin(2)	14						AGCACAGCAGTTGACAGCCTC	0.512000													9	116					0	0	1	0	0
GART	2618	broad.mit.edu	37	21	34878390	34878390	+	Missense_Mutation	SNP	A	A	G			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr21:34878390A>G	ENST00000381831.3	-	19	2737	c.2474T>C	c.(2473-2475)aTa>aCa	p.I825T	GART_ENST00000543717.1_Missense_Mutation_p.I377T|GART_ENST00000381839.3_Missense_Mutation_p.I825T|GART_ENST00000381815.4_Missense_Mutation_p.I825T	NM_001136005.1	NP_001129477.1	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	825	GART.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(13)|ovary(3)|prostate(5)|urinary_tract(1)	31					Pemetrexed(DB00642)	AGTACTGTCTATAAGTGCTTG	0.428000													29	55					0	0	1	0	0
PRPF4B	8899	broad.mit.edu	37	6	4021681	4021681	+	Missense_Mutation	SNP	T	T	G			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr6:4021681T>G	ENST00000337659.6	+	1	122	c.22T>G	c.(22-24)Tcg>Gcg	p.S8A		NM_003913.4	NP_003904.3	Q13523	PRP4B_HUMAN	pre-mRNA processing factor 4B	8						catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(6)|endometrium(3)|large_intestine(5)|lung(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	22	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				GGAGACCCAGTCGCTACGGGA	0.662000													11	10					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54799462	54799462	+	Silent	SNP	G	G	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr12:54799462G>A	ENST00000293379.4	-	11	1263	c.1002C>T	c.(1000-1002)gaC>gaT	p.D334D	RP11-753H16.3_ENST00000550474.1_RNA|RP11-753H16.5_ENST00000552785.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	334					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						CCCCATTGACGTCTGTGGCGG	0.547000													43	35					0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54848852	54848852	+	Missense_Mutation	SNP	C	C	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr19:54848852C>A	ENST00000291759.4	-	5	827	c.771G>T	c.(769-771)aaG>aaT	p.K257N		NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	257	Ig-like C2-type 3.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		CGGCCCCCTCCTTGTACAGAG	0.672000													10	68					7.48243e-07	7.77021e-07	1	1	0
LCP1	3936	broad.mit.edu	37	13	46733004	46733004	+	Missense_Mutation	SNP	T	T	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr13:46733004T>A	ENST00000398576.2	-	6	573	c.185A>T	c.(184-186)gAt>gTt	p.D62V	LCP1_ENST00000323076.2_Missense_Mutation_p.D62V			P13796	PLSL_HUMAN	lymphocyte cytosolic protein 1 (L-plastin)	62	EF-hand 2.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			breast(2)|kidney(1)|large_intestine(6)|lung(18)|ovary(4)|prostate(2)|skin(1)	34		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		TTGGTCCAGATCACCTGTAGC	0.418000			T	BCL6	NHL								70	57					0	0	1	0	0
TRPM4	54795	broad.mit.edu	37	19	49713575	49713575	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr19:49713575G>A	ENST00000252826.5	+	21	3367	c.3241G>A	c.(3241-3243)Gtc>Atc	p.V1081I	TRPM4_ENST00000427978.2_Missense_Mutation_p.V936I|TRPM4_ENST00000355712.5_Missense_Mutation_p.V727I	NM_017636.3	NP_060106.2	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel, subfamily M, member 4	1081	Calmodulin-binding.				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		GCCCTTTATCGTCATCTCCCA	0.642000													13	130					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371964	240371964	+	Missense_Mutation	SNP	G	G	C			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr1:240371964G>C	ENST00000319653.9	+	5	4082	c.3852G>C	c.(3850-3852)aaG>aaC	p.K1284N		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1284	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GGAGTAGGAAGCAGCCCATAG	0.468000													9	60					0	0	1	0	0
OR10A7	121364	broad.mit.edu	37	12	55615303	55615303	+	Silent	SNP	C	C	T			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr12:55615303C>T	ENST00000326258.1	+	1	495	c.495C>T	c.(493-495)gcC>gcT	p.A165A		NM_001005280.1	NP_001005280.1	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A, member 7	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|lung(11)|ovary(4)|prostate(2)|skin(3)	24						GGATGATGGCCCTTCCTTTCT	0.473000													9	44					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136597335	136597335	+	Nonsense_Mutation	SNP	G	G	C			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr6:136597335G>C	ENST00000531224.1	-	5	1580	c.1328C>G	c.(1327-1329)tCa>tGa	p.S443*	BCLAF1_ENST00000527759.1_Nonsense_Mutation_p.S441*|BCLAF1_ENST00000353331.4_Nonsense_Mutation_p.S441*|BCLAF1_ENST00000392348.2_Nonsense_Mutation_p.S441*|BCLAF1_ENST00000527536.1_Nonsense_Mutation_p.S443*|BCLAF1_ENST00000530767.1_Intron	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	443					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		GCCTTTCAGTGAAACTTTGGA	0.398000													32	135					0	0	1	0	0
CASZ1	54897	broad.mit.edu	37	1	10713827	10713827	+	Missense_Mutation	SNP	T	T	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr1:10713827T>A	ENST00000377022.3	-	11	2604	c.2287A>T	c.(2287-2289)Agt>Tgt	p.S763C	CASZ1_ENST00000344008.5_Missense_Mutation_p.S763C|RP4-734G22.3_ENST00000606802.1_RNA	NM_001079843.1	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	763					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		TTGGTGGCACTGGGCCCAGCC	0.701000													8	47					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803493	142803493	+	RNA	SNP	T	T	C	rs80149641	by1000genomes	TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr1:142803493T>C	ENST00000423385.1	-	0	1472																											TGTACATTTATTATTGATTTA	0.323000													9	83					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124911256	124911256	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr12:124911256C>T	ENST00000356219.3	-	12	1395	c.1240G>A	c.(1240-1242)Ggg>Agg	p.G414R	NCOR2_ENST00000405201.1_Missense_Mutation_p.G414R|NCOR2_ENST00000429285.2_Missense_Mutation_p.G413R|NCOR2_ENST00000404121.2_5'UTR|NCOR2_ENST00000404621.1_Missense_Mutation_p.G413R|NCOR2_ENST00000397355.1_Missense_Mutation_p.G414R	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	414					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GCCATAAGCCCGTTCATGTTG	0.572000													24	42					0	0	1	0	0
EIF3I	8668	broad.mit.edu	37	1	32694780	32694780	+	Silent	SNP	C	C	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr1:32694780C>A	ENST00000373586.1	+	9	846	c.774C>A	c.(772-774)acC>acA	p.T258T		NM_003757.2	NP_003748.1	Q13347	EIF3I_HUMAN	eukaryotic translation initiation factor 3, subunit I	258						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)				TAACCACAACCTCCACCAGGA	0.443000													27	45					2.41591e-17	2.66139e-17	1	1	0
BRWD1	54014	broad.mit.edu	37	21	40571181	40571181	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr21:40571181C>T	ENST00000342449.3	-	40	5239	c.5161G>A	c.(5161-5163)Gag>Aag	p.E1721K	BRWD1_ENST00000380800.3_Missense_Mutation_p.E1721K|BRWD1_ENST00000333229.2_Missense_Mutation_p.E1721K	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1721					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				CTTTCTGACTCTGAGTCTCTG	0.398000													35	48					0	0	1	0	0
SLC4A7	9497	broad.mit.edu	37	3	27475588	27475588	+	Silent	SNP	T	T	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr3:27475588T>A	ENST00000295736.5	-	6	640	c.570A>T	c.(568-570)gtA>gtT	p.V190V	SLC4A7_ENST00000440156.1_Silent_p.V199V|SLC4A7_ENST00000455077.1_Silent_p.V195V|SLC4A7_ENST00000435667.2_Silent_p.V199V|SLC4A7_ENST00000388777.4_5'UTR|SLC4A7_ENST00000428386.1_Silent_p.V190V|SLC4A7_ENST00000437179.1_Silent_p.V195V|SLC4A7_ENST00000445684.1_Silent_p.V199V|SLC4A7_ENST00000446700.1_Silent_p.V195V|SLC4A7_ENST00000454389.1_Silent_p.V199V|SLC4A7_ENST00000425128.2_Silent_p.V195V	NM_003615.4	NP_003606.3	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 7	190						apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(9)|ovary(4)|skin(1)	38						TGTTGTCTAATACCATATCTA	0.323000													4	29					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7573982	7573982	+	Nonsense_Mutation	SNP	C	C	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr17:7573982C>A	ENST00000269305.4	-	10	1234	c.1045G>T	c.(1045-1047)Gaa>Taa	p.E349*	TP53_ENST00000445888.2_Nonsense_Mutation_p.E349*|TP53_ENST00000359597.4_Intron|TP53_ENST00000420246.2_3'UTR|TP53_ENST00000455263.2_3'UTR|TP53_ENST00000413465.2_Intron	NM_000546.5|NM_001126112.2|NM_001126118.1|NM_001276760.1|NM_001276761.1	NP_000537.3|NP_001119584.1|NP_001119590.1|NP_001263689.1|NP_001263690.1	P04637	P53_HUMAN	tumor protein p53	349	Interaction with CARM1.|Interaction with HIPK1 (By similarity).|Interaction with HIPK2.|Oligomerization.		E -> D (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E349*(11)|p.0?(8)|p.L348_E349>F*(2)|p.E349fs*21(2)|p.?(1)|p.I332fs*5(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCCTTGAGTTCCAAGGCCTCA	0.597000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			28	4					4.43304e-23	4.98716e-23	1	1	0
HTR1E	3354	broad.mit.edu	37	6	87725129	87725129	+	Missense_Mutation	SNP	G	G	T			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr6:87725129G>T	ENST00000305344.4	+	2	780	c.77G>T	c.(76-78)tGc>tTc	p.C26F	HTR1E_ENST00000369584.1_Missense_Mutation_p.C26F	NM_000865.2	NP_000856.1	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled	26					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			breast(3)|endometrium(2)|kidney(3)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(3)	41		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	ATGCTCATTTGCATGACTCTG	0.498000													49	41					2.43139e-17	2.66139e-17	1	1	0
KIAA1429	25962	broad.mit.edu	37	8	95518910	95518910	+	Silent	SNP	A	A	T			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr8:95518910A>T	ENST00000297591.5	-	16	3990	c.3915T>A	c.(3913-3915)ggT>ggA	p.G1305G	KIAA1429_ENST00000437199.1_Silent_p.G1305G	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	1305					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			CAGAAATAGAACCTTCAGAAG	0.393000													19	132					0	0	1	0	0
HHIP	64399	broad.mit.edu	37	4	145580927	145580927	+	Silent	SNP	T	T	C			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr4:145580927T>C	ENST00000296575.3	+	4	1423	c.768T>C	c.(766-768)ccT>ccC	p.P256P	HHIP_ENST00000434550.2_Silent_p.P256P|HHIP_ENST00000511314.1_3'UTR|HHIP-AS1_ENST00000512359.1_RNA	NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	256						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		TACTTACCCCTGAAGGAGAAA	0.428000													58	72					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518497	113518497	+	Nonsense_Mutation	SNP	G	G	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr7:113518497G>A	ENST00000284601.3	-	4	2718	c.2650C>T	c.(2650-2652)Cag>Tag	p.Q884*		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	884					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TCTTGAACCTGCCTAAGATCT	0.368000													9	48					0	0	1	0	0
BCL2L11	10018	broad.mit.edu	37	2	111921771	111921772	+	Frame_Shift_Ins	INS	-	-	A			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr2:111921771_111921772insA	ENST00000393256.3	+	4	833_834	c.560_561insA	c.(559-561)tcgfs	p.S187fs	BCL2L11_ENST00000308659.8_Frame_Shift_Ins_p.S127fs	NM_001204106.1|NM_006538.4|NM_138621.4|NM_138627.3	NP_001191035.1|NP_006529.1|NP_619527.1|NP_619533.1	O43521	B2L11_HUMAN	BCL2-like 11 (apoptosis facilitator)	187					activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	cytosol|endomembrane system|mitochondrial outer membrane|plasma membrane	protein binding			endometrium(4)|large_intestine(3)|lung(2)|prostate(2)	11						TTACGACTGTTACGTTACATTG	0.436													37	75	---	---	---	---					
HLA-DRB6	0	broad.mit.edu	37	6	32521843	32521844	+	RNA	DEL	CT	CT	-	rs67101368		TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr6:32521843_32521844delCT	ENST00000411500.1	-	0	740					NR_001298.1																						AGAAGGCTACCTCCTGTAAGAA	0.356													4	3	---	---	---	---					
RRM1	6240	broad.mit.edu	37	11	4123271	4123272	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr11:4123271_4123272delAG	ENST00000300738.5	+	2	272_273	c.68_69delAG	c.(67-69)cfs	p.Q23fs	RRM1_ENST00000423050.2_5'UTR	NM_001033.3	NP_001024.1	P23921	RIR1_HUMAN	ribonucleotide reductase M1	23	ATP-cone.				deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleoplasm|ribonucleoside-diphosphate reductase complex	ATP binding|ribonucleoside-diphosphate reductase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)	14		Medulloblastoma(188;0.0025)|Breast(177;0.00502)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0848)|LUSC - Lung squamous cell carcinoma(625;0.205)	Clofarabine(DB00631)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Hydroxyurea(DB01005)	TCTCGAATCCAGAAGCTTTGTT	0.327													19	32	---	---	---	---					
RPH3A	22895	broad.mit.edu	37	12	113285511	113285515	+	Frame_Shift_Del	DEL	GGCTG	GGCTG	-			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr12:113285511_113285515delGGCTG	ENST00000389385.4	+	5	591_595	c.94_98delGGCTG	c.(94-99)gfs	p.GW32fs	RPH3A_ENST00000447659.2_Intron|RPH3A_ENST00000415485.3_Frame_Shift_Del_p.GW32fs|RPH3A_ENST00000548866.1_Intron|RPH3A_ENST00000551052.1_Frame_Shift_Del_p.GW28fs|RPH3A_ENST00000420983.2_Frame_Shift_Del_p.GW32fs|RPH3A_ENST00000543106.2_Frame_Shift_Del_p.GW32fs	NM_001143854.1|NM_014954.3	NP_001137326.1|NP_055769.2	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog (mouse)	32					intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		GCTCCAGGCAGGCTGGTCCGTCCAC	0.537													25	33	---	---	---	---					
CAPN15	6650	broad.mit.edu	37	16	601377	601377	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr16:601377delC	ENST00000219611.2	+	8	2505	c.2142delC	c.(2140-2142)cgfs	p.R714fs	LA16c-366D1.3_ENST00000565879.1_RNA	NM_005632.2	NP_005623.1			calpain 15																		TGGGCCTGCGCCCCCGGCATG	0.682													55	62	---	---	---	---