Hugo_Symbol Entrez_Gene_Id Center NCBI_Build Chromosome Start_position End_position Strand Variant_Classification Variant_Type Reference_Allele Tumor_Seq_Allele1 Tumor_Seq_Allele2 dbSNP_RS dbSNP_Val_Status Tumor_Sample_Barcode Matched_Norm_Sample_Barcode Match_Norm_Seq_Allele1 Match_Norm_Seq_Allele2 Tumor_Validation_Allele1 Tumor_Validation_Allele2 Match_Norm_Validation_Allele1 Match_Norm_Validation_Allele2 Verification_Status Validation_Status Mutation_Status Sequencing_Phase Sequence_Source Validation_Method Score BAM_file Sequencer Tumor_Sample_UUID Matched_Norm_Sample_UUID transcript_name strand transcript_status amino_acid_change ucsc_cons normal_depth normal_vaf tumor_depth tumor_vaf rna_depth rna_vaf polyphen sift condel domain NBPF1 55672 genome.wustl.edu 37 1 16891365 16891365 + Missense_Mutation SNP G G A novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_017940.3 -1 predicted p.T1022M 0.001 43 2.3% 44 31.8% 10 30% - - - NULL EPHB2 2048 genome.wustl.edu 37 1 23110965 23110965 + Silent SNP G G A novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_004442.6 +1 reviewed p.Q69 1.000 59 0% 61 24.6% 13 23% - - - HMMPfam_Ephrin_lbd,HMMSmart_EPH_lbd,superfamily_Gal_bind_like RNPC3 55599 genome.wustl.edu 37 1 104078803 104078803 + Missense_Mutation SNP C C T novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_017619.3 +1 reviewed p.A204V 0.992 146 0% 161 21.7% 2 50% benign(0.027) tolerated(0.11) neutral(0.273) NULL EFNA4 1945 genome.wustl.edu 37 1 155041445 155041445 + Missense_Mutation SNP C C T novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_005227.2 +1 reviewed p.R196C 0.988 243 0% 225 23.1% 8 25% unknown(0) - - NULL CYP27C1 339761 genome.wustl.edu 37 2 127957048 127957048 + Silent SNP G G A novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_001001665.3 -1 reviewed p.S152 0.008 179 0% 163 24.5% 0 - - - - HMMPfam_p450,superfamily_Cytochrome P450 XIRP2 129446 genome.wustl.edu 37 2 168110547 168110547 + Missense_Mutation SNP G G T novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_152381.4 +1 validated p.A3521S 0.246 100 0% 103 23.3% 0 - possibly_damaging(0.586) tolerated(0.13) neutral(0.455) NULL RAD18 56852 genome.wustl.edu 37 3 8944096 8944098 + In_Frame_Del DEL TCA TCA - novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 TCA TCA Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_020165.3 -1 reviewed p.D378in_frame_del 0.779:0.981:0.987 - - - - - - - - - NULL PLXNB1 5364 genome.wustl.edu 37 3 48452292 48452292 + Missense_Mutation SNP G G A novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_001130082.1 -1 validated p.R1801C 0.963 66 0% 86 15.1% 41 46.3% benign(0.001) tolerated(0.23) neutral(0.042) superfamily_GTPase activation domain GAP,HMMPfam_Plexin_cytopl PIK3CA 5290 genome.wustl.edu 37 3 178936094 178936094 + Missense_Mutation SNP C C A rs121913286 byCluster TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_006218.2 +1 reviewed p.Q546K 1.000 207 0% 236 34.3% 4 50% probably_damaging(0.978) tolerated(0.11) deleterious(0.692) HMMPfam_PI3Ka,HMMSmart_PI3Ka,superfamily_ARM-type_fold NAA15 80155 genome.wustl.edu 37 4 140306014 140306014 + Frame_Shift_Del DEL T T - novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_057175.3 +1 validated p.D728fs 0.984 - - - - - - - - - NULL FBXW7 55294 genome.wustl.edu 37 4 153250883 153250883 + Nonsense_Mutation SNP G G A novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_033632.2 -1 reviewed p.R393* 1.000 171 0% 174 20.1% 4 25% - - - HMMSmart_SM00320,superfamily_WD40 repeat-like,HMMPfam_WD40 ZDHHC14 79683 genome.wustl.edu 37 6 158066798 158066798 + Missense_Mutation SNP C C T novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_024630.2 +1 provisional p.S261F 0.936 229 0% 237 23.6% 5 40% possibly_damaging(0.858) tolerated(0.1) deleterious(0.617) NULL LPA 4018 genome.wustl.edu 37 6 161027548 161027548 + Missense_Mutation SNP T T C novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_005577.2 -1 reviewed p.I916V 0.000 143 0% 132 11.4% 0 - benign(0) tolerated(1) - superfamily_Kringle-like INTS1 26173 genome.wustl.edu 37 7 1510261 1510261 + Silent SNP C C T novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_001080453.2 -1 validated p.A2175 0.909 27 0% 44 20.5% 147 40.1% - - - NULL MUC12 10071 genome.wustl.edu 37 7 100646182 100646182 + Nonsense_Mutation SNP C C G novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 ENST00000379442 +1 known p.S4256* 0.006 300 0.3% 376 9.8% 0 - - - - NULL PRKAG2 51422 genome.wustl.edu 37 7 151483613 151483613 + Silent SNP G G A novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_016203.3 -1 reviewed p.F43 0.996 66 0% 63 25.4% 0 - - - - NULL CACNA1B 774 genome.wustl.edu 37 9 140777292 140777292 + Missense_Mutation SNP C C T novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_000718.2 +1 validated p.R163W 1.000 265 0% 241 13.7% 0 - possibly_damaging(0.943) deleterious(0) deleterious(0.832) HMMPfam_Ion_trans,superfamily_Voltage-gated potassium channels LSP1 4046 genome.wustl.edu 37 11 1874398 1874398 + Silent SNP G G A novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_002339.2 +1 reviewed p.P8 0.000 141 0% 134 32.8% 5 0% - - - NULL KDM2A 22992 genome.wustl.edu 37 11 66985227 66985227 + Missense_Mutation SNP C C T novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_012308.2 +1 reviewed p.A238V 1.000 255 0% 273 33% 16 56.2% benign(0.092) tolerated(0.25) neutral(0.044) HMMSmart_SM00558,HMMPfam_JmjC,superfamily_Clavaminate synthase-like CHD4 1108 genome.wustl.edu 37 12 6697096 6697096 + Missense_Mutation SNP C C T novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_001273.2 -1 reviewed p.R1162Q 1.000 104 0% 113 22.1% 74 56.7% probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMPfam_Helicase_C,HMMSmart_SM00490,superfamily_P-loop containing nucleoside triphosphate hydrolases SOX5 6660 genome.wustl.edu 37 12 23818392 23818392 + Missense_Mutation SNP T T C novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_006940.4 -1 reviewed p.Y306C 1.000 82 0% 96 12.5% 0 - probably_damaging(0.999) deleterious(0) deleterious(0.935) NULL SRRM4 84530 genome.wustl.edu 37 12 119588923 119588923 + Missense_Mutation SNP C C T novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_194286.2 +1 validated p.S393F 0.990 131 0% 125 26.4% 0 - probably_damaging(0.978) deleterious(0.03) deleterious(0.785) NULL C12orf65 91574 genome.wustl.edu 37 12 123741495 123741495 + Missense_Mutation SNP G G A novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_001143905.1 +1 validated p.E140K 1.000 172 0% 116 22.4% 7 28.5% unknown(0) tolerated(0.37) - NULL FBLN5 10516 genome.wustl.edu 37 14 92403397 92403397 + Silent SNP C C T novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_006329.3 -1 reviewed p.P91 0.000 134 0% 163 23.3% 5 0% - - - NULL TP53 7157 genome.wustl.edu 37 17 7577538 7577538 + Missense_Mutation SNP C C T novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_000546.4 -1 reviewed p.R248Q 1.000 112 0% 110 52.7% 85 92.9% probably_damaging(1) deleterious(0.01) deleterious(0.905) PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53 CCDC144A 9720 genome.wustl.edu 37 17 16631011 16631011 + Missense_Mutation SNP G G A novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_014695.1 +1 provisional p.E688K 0.999 575 0% 611 10% 0 - benign(0.096) tolerated(0.21) neutral(0.051) NULL NPEPPS 9520 genome.wustl.edu 37 17 45691041 45691041 + Silent SNP C C T novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_006310.3 +1 reviewed p.L749 1.000 571 0% 568 23.8% 50 50% - - - NULL ARHGAP35 2909 genome.wustl.edu 37 19 47424736 47424736 + Frame_Shift_Del DEL A A - novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_004491.4 +1 reviewed p.H935fs 1.000 - - - - - - - - - NULL LIG1 3978 genome.wustl.edu 37 19 48626232 48626232 + Missense_Mutation SNP C C T novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_000234.1 -1 reviewed p.A731T 1.000 165 0% 128 29.7% 26 61.5% probably_damaging(0.999) deleterious(0.01) deleterious(0.896) HMMPfam_DNA_ligase_A_M,PatternScan_DNA_LIGASE_A2,superfamily_DNA ligase/mRNA capping enzyme catalytic domain LIG1 3978 genome.wustl.edu 37 19 48653466 48653466 + Missense_Mutation SNP T T G novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_000234.1 -1 reviewed p.K192N 0.017 153 0% 112 28.6% 8 75% benign(0) tolerated(0.46) neutral(0.012) NULL SALL4 57167 genome.wustl.edu 37 20 50405676 50405676 + Silent SNP C C A novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_020436.3 -1 reviewed p.R822 0.879 38 0% 45 20% 0 - - - - NULL CELSR1 9620 genome.wustl.edu 37 22 46860088 46860088 + Silent SNP G G A rs3747251 byCluster;byFrequency;by2Hit2Allele;by1000genomes TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 ENST00000454637 -1 known p.P608L 0.015 39 0% 47 12.8% 10 10% - - - NULL DMD 1756 genome.wustl.edu 37 X 31196794 31196794 + Missense_Mutation SNP G G T novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_004006.2 -1 reviewed p.N3405K 1.000 310 0.6% 279 30.1% 1 100% probably_damaging(1) deleterious(0.01) deleterious(0.905) NULL CACNA1F 778 genome.wustl.edu 37 X 49075803 49075803 + Nonsense_Mutation SNP G G A rs122456135 TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_005183.2 -1 reviewed p.R895* 1.000 136 0% 143 20.3% 0 - - - - superfamily_Voltage-gated potassium channels CDX4 1046 genome.wustl.edu 37 X 72667325 72667325 + Missense_Mutation SNP C C T novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_005193.1 +1 provisional p.P79L 0.999 51 0% 49 22.4% 0 - benign(0.002) deleterious(0) neutral(0.445) HMMPfam_Caudal_act DACH2 117154 genome.wustl.edu 37 X 85969556 85969556 + Missense_Mutation SNP G G T novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_053281.3 +1 reviewed p.D313Y 1.000 207 0% 189 25.4% 0 - probably_damaging(0.999) deleterious(0) deleterious(0.935) NULL NXF2 56001 genome.wustl.edu 37 X 101572395 101572395 + Missense_Mutation SNP G G A novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_017809.3 +1 reviewed p.R98H 0.000 456 0% 446 13.5% 0 - benign(0) tolerated(1) - NULL COL4A5 1287 genome.wustl.edu 37 X 107826158 107826158 + Silent SNP T T C novel TCGA-D1-A16G-01A-31D-A12J-09 TCGA-D1-A16G-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 65f9a820-f026-4a10-8bb7-1fbc3b38321e 6d3d68e8-21d1-40af-9b9f-933980a38801 NM_033380.1 +1 reviewed p.D327 1.000 445 0% 417 23% 6 0% - - - HMMPfam_Collagen