Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TSC22D1	8848	broad.mit.edu	37	13	45008991	45008991	+	Missense_Mutation	SNP	G	G	A			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr13:45008991G>A	ENST00000458659.2	-	3	3483	c.2993C>T	c.(2992-2994)gCg>gTg	p.A998V	TSC22D1_ENST00000501704.2_Intron|TSC22D1_ENST00000261489.2_Missense_Mutation_p.A69V	NM_183422.3	NP_904358.2	Q15714	T22D1_HUMAN	TSC22 domain family, member 1	998					transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		TTCTCTGACCGCATACATCAA	0.403000													4	157					0	0	1	0	0
KRBA2	124751	broad.mit.edu	37	17	8273090	8273090	+	Missense_Mutation	SNP	T	T	C			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr17:8273090T>C	ENST00000396267.1	-	2	1426	c.595A>G	c.(595-597)Att>Gtt	p.I199V	RP11-849F2.7_ENST00000582471.1_3'UTR|KRBA2_ENST00000331336.2_Missense_Mutation_p.I281V|RP11-849F2.5_ENST00000580537.1_RNA|RP11-849F2.5_ENST00000583963.1_RNA			Q6ZNG9	KRBA2_HUMAN	KRAB-A domain containing 2	281					DNA integration|regulation of transcription, DNA-dependent	intracellular	DNA binding			endometrium(2)|kidney(2)|large_intestine(7)|lung(5)|stomach(1)|urinary_tract(1)	18						TAGTATAAAATGAACTTGAAC	0.423000													46	51					0	0	1	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52001329	52001329	+	Missense_Mutation	SNP	T	T	A			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr19:52001329T>A	ENST00000291707.3	-	5	1403	c.1348A>T	c.(1348-1350)Aac>Tac	p.N450Y	SIGLEC12_ENST00000598614.1_Missense_Mutation_p.N332Y	NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	450	Ig-like C2-type 2.				cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CCTAGAGGGTTCTGAGCTCGG	0.592000													20	53					0	0	1	0	0
RP11-1166P10.6	0	broad.mit.edu	37	16	32070612	32070612	+	RNA	SNP	A	A	C			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr16:32070612A>C	ENST00000566806.1	-	0	499																											GGTCTCCTGCAAGGCTTCTGG	0.552000													6	127					0	0	1	0	0
HOXD12	3238	broad.mit.edu	37	2	176964709	176964709	+	Silent	SNP	C	C	A			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr2:176964709C>A	ENST00000406506.2	+	1	252	c.180C>A	c.(178-180)ccC>ccA	p.P60P	HOXD12_ENST00000404162.2_Silent_p.P60P			P35452	HXD12_HUMAN	homeobox D12	60						nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(1)|lung(7)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0521)|READ - Rectum adenocarcinoma(9;0.0678)		CCTGCGCCCCCGCGCAGCCTG	0.751000													3	45					0.014758	0.0163115	1	1	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274087	39274087	+	Missense_Mutation	SNP	G	G	C	rs141357429	by1000genomes	TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr17:39274087G>C	ENST00000391413.2	-	1	519	c.481C>G	c.(481-483)Ctg>Gtg	p.L161V		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	161	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.L161V(1)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACTGGACGCAGGcagcagcag	0.657000													6	24					0	0	1	0	0
LUZP4	51213	broad.mit.edu	37	X	114537972	114537972	+	Missense_Mutation	SNP	T	T	G			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chrX:114537972T>G	ENST00000371920.3	+	3	338	c.331T>G	c.(331-333)Tta>Gta	p.L111V	LUZP4_ENST00000451986.2_Intron	NM_016383.3	NP_057467.1	Q9P127	LUZP4_HUMAN	leucine zipper protein 4	111						nucleus				endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	14						TGGGCAGCCTTTAATTGAGCA	0.318000													5	208					0	0	1	0	0
SPATA13	221178	broad.mit.edu	37	13	24860393	24860393	+	Missense_Mutation	SNP	G	G	T			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr13:24860393G>T	ENST00000424834.2	+	8	2816	c.2343G>T	c.(2341-2343)tgG>tgT	p.W781C	SPATA13_ENST00000409126.1_Missense_Mutation_p.W78C|SPATA13_ENST00000343003.6_Missense_Mutation_p.W100C|SPATA13_ENST00000382095.4_Missense_Mutation_p.W156C|SPATA13_ENST00000399949.2_Missense_Mutation_p.W78C|SPATA13_ENST00000382108.3_Missense_Mutation_p.W781C			Q96N96	SPT13_HUMAN	spermatogenesis associated 13	156					cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			breast(4)|endometrium(2)|large_intestine(9)|lung(4)|ovary(1)|prostate(1)|skin(2)	23		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		AAGCCCTGTGGGACCATGTGA	0.602000													65	94					1.1794e-34	1.50106e-34	1	1	0
SLC2A11	66035	broad.mit.edu	37	22	24210757	24210757	+	Silent	SNP	C	C	A			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr22:24210757C>A	ENST00000345044.6	+	3	478	c.210C>A	c.(208-210)atC>atA	p.I70I	SLC2A11_ENST00000467660.1_3'UTR|SLC2A11_ENST00000316185.8_Silent_p.I73I|AP000350.10_ENST00000433835.3_Silent_p.I35I|SLC2A11_ENST00000405847.1_Silent_p.I70I|SLC2A11_ENST00000403208.3_Silent_p.I70I|SLC2A11_ENST00000398356.2_Silent_p.I77I			Q9BYW1	GTR11_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 11	70						integral to membrane|plasma membrane	sugar transmembrane transporter activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(2)	12						GGTCCCTCATCGTGTCTCTGT	0.562000													4	114					0.150653	0.150653	1	1	0
DRD5	0	broad.mit.edu	37	4	9784028	9784028	+	Silent	SNP	T	T	C	rs2227841	byFrequency	TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr4:9784028T>C	ENST00000304374.2	+	1	771	c.375T>C	c.(373-375)acT>acC	p.T125T		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	125					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	TGTGCTCCACTGCCTCCATCC	0.622000													5	73					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107783004	107783004	+	Missense_Mutation	SNP	A	A	T			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chrX:107783004A>T	ENST00000328300.6	+	2	354	c.110A>T	c.(109-111)aAg>aTg	p.K37M	COL4A5_ENST00000361603.2_Missense_Mutation_p.K37M	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	37	Nonhelical region (NC2).				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						CCAGGATCAAAGTGTGACTGC	0.353000									Alport syndrome with Diffuse Leiomyomatosis				5	168					0	0	1	0	0
PDE4D	5144	broad.mit.edu	37	5	58270678	58270678	+	Missense_Mutation	SNP	G	G	A			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr5:58270678G>A	ENST00000340635.6	-	15	2418	c.2243C>T	c.(2242-2244)aCg>aTg	p.T748M	PDE4D_ENST00000358923.6_Missense_Mutation_p.T446M|PDE4D_ENST00000507116.1_Missense_Mutation_p.T684M|PDE4D_ENST00000546160.1_Missense_Mutation_p.T687M|PDE4D_ENST00000317118.8_Missense_Mutation_p.T457M|PDE4D_ENST00000405755.2_Missense_Mutation_p.T626M|PDE4D_ENST00000360047.5_Missense_Mutation_p.T612M|PDE4D_ENST00000503258.1_Missense_Mutation_p.T618M|PDE4D_ENST00000502484.2_Missense_Mutation_p.T687M	NM_001104631.1	NP_001098101.1	Q08499	PDE4D_HUMAN	phosphodiesterase 4D, cAMP-specific	748					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|pancreas(1)	15		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	GTCCTTTTCCGTGTCTGACTC	0.493000													5	352					0	0	1	0	0
CSAG4	0	broad.mit.edu	37	X	151896589	151896589	+	RNA	SNP	C	C	A			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chrX:151896589C>A	ENST00000361201.4	-	0	351					NR_073432.1													p.L11F(1)		endometrium(2)|kidney(2)|lung(1)	5						GGTTGTTGGACAATGGGCTGG	0.557000													6	297					0.0293803	0.0316404	1	1	0
CXorf40B	541578	broad.mit.edu	37	X	149101910	149101910	+	Silent	SNP	G	G	T	rs139086529	byFrequency	TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chrX:149101910G>T	ENST00000370406.3	-	4	1011	c.183C>A	c.(181-183)ctC>ctA	p.L61L	CXorf40B_ENST00000370404.1_Silent_p.L61L|CXorf40B_ENST00000355203.2_Silent_p.L61L|CXorf40B_ENST00000462691.1_Silent_p.L61L			Q96DE9	CX04B_HUMAN	chromosome X open reading frame 40B	61										endometrium(1)|lung(4)	5	Acute lymphoblastic leukemia(192;6.56e-05)					GAGTCATCCCGAGTCTCTCCA	0.567000													15	269					0.000422831	0.000479971	1	1	0
XIRP2	129446	broad.mit.edu	37	2	168104097	168104097	+	Missense_Mutation	SNP	G	G	T			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr2:168104097G>T	ENST00000409195.1	+	9	6284	c.6195G>T	c.(6193-6195)tgG>tgT	p.W2065C	XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.W2065C|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.W1843C|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000420519.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1890					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						CGGGTGTCTGGACTGATACTA	0.358000													4	60					1.23904e-05	1.48685e-05	1	1	0
TYMP	1890	broad.mit.edu	37	22	50967924	50967924	+	Splice_Site	SNP	C	C	G			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr22:50967924C>G	ENST00000252029.3	-	2	377		c.e2+1		TYMP_ENST00000395678.3_Splice_Site|TYMP_ENST00000395680.1_Splice_Site|TYMP_ENST00000395681.1_Splice_Site	NM_001113755.2|NM_001113756.2|NM_001257988.1|NM_001257989.1|NM_001953.4	NP_001107227.1|NP_001107228.1|NP_001244917.1|NP_001244918.1|NP_001944.1	P19971	TYPH_HUMAN	thymidine phosphorylase						angiogenesis|cell differentiation|chemotaxis|DNA replication|mitochondrial genome maintenance|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol	growth factor activity|platelet-derived growth factor receptor binding|pyrimidine-nucleoside phosphorylase activity|thymidine phosphorylase activity			large_intestine(1)|lung(2)|ovary(1)|prostate(1)	5		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)	Capecitabine(DB01101)|Docetaxel(DB01248)|Floxuridine(DB00322)|Fluorouracil(DB00544)|Sulfasalazine(DB00795)|Tamoxifen(DB00675)	TCCCCACGCACCGATCTGTGC	0.687000													4	139					0	0	1	0	0
JAK2	3717	broad.mit.edu	37	9	5044449	5044449	+	Missense_Mutation	SNP	C	C	T			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr9:5044449C>T	ENST00000381652.3	+	5	891	c.397C>T	c.(397-399)Cgg>Tgg	p.R133W	JAK2_ENST00000544510.1_5'UTR|JAK2_ENST00000539801.1_Missense_Mutation_p.R133W	NM_004972.3	NP_004963.1	O60674	JAK2_HUMAN	Janus kinase 2	133	FERM.|Interaction with cytokine/interferon/growth hormone receptors (By similarity).				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)|ETV6/JAK2(11)|PCM1/JAK2(30)|PAX5/JAK2(18)	breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(32944)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(4)|skin(2)|urinary_tract(1)	32998	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		CAGAGCCTATCGGCATGGAAT	0.383000		1	"""T, Mis, O"""	"""ETV6, PCM1, BCR"""	"""ALL, AML, MPD,  CML"""				Polycythemia Vera, Familial				26	43					0	0	1	0	0
RHBDD3	25807	broad.mit.edu	37	22	29660060	29660060	+	Missense_Mutation	SNP	G	G	T			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr22:29660060G>T	ENST00000216085.7	-	4	720	c.296C>A	c.(295-297)gCt>gAt	p.A99D		NM_012265.1	NP_036397.1	Q9Y3P4	RHBD3_HUMAN	rhomboid domain containing 3	99						integral to membrane	serine-type endopeptidase activity			lung(1)|ovary(1)	2						CAGCCCAGAAGCCAGGGCGAG	0.672000													3	13					6.4e-05	7.46667e-05	1	1	0
ADAMTS19	171019	broad.mit.edu	37	5	128844806	128844806	+	Missense_Mutation	SNP	A	A	T			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr5:128844806A>T	ENST00000274487.4	+	3	911	c.766A>T	c.(766-768)Att>Ttt	p.I256F	CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	256					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CTTCATATTTATTGAGCCACT	0.358000													5	47					0	0	1	0	0
BCORL1	63035	broad.mit.edu	37	X	129159215	129159215	+	Missense_Mutation	SNP	C	C	A			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chrX:129159215C>A	ENST00000540052.1	+	6	3983	c.3939C>A	c.(3937-3939)gaC>gaA	p.D1313E	BCORL1_ENST00000218147.7_Missense_Mutation_p.D1313E|BCORL1_ENST00000303743.5_Missense_Mutation_p.D1313E|BCORL1_ENST00000359304.2_Intron	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	1313					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						AAATGTGGGACACCAATgagg	0.587000													4	91					0.150653	0.150653	1	1	0
ZFYVE20	64145	broad.mit.edu	37	3	15115677	15115677	+	Missense_Mutation	SNP	C	C	T	rs147577833	byFrequency	TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr3:15115677C>T	ENST00000253699.3	-	14	2580	c.1967G>A	c.(1966-1968)cGc>cAc	p.R656H	ZFYVE20_ENST00000476527.2_Missense_Mutation_p.R656H	NM_022340.2	NP_071735.2	Q9H1K0	RBNS5_HUMAN	zinc finger, FYVE domain containing 20	656	Necessary for the interaction with EHD1.|Necessary for the interaction with RAB5A.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			NS(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|skin(3)|stomach(1)|urinary_tract(2)	26						TTTCAGGATGCGGGCTGAAGG	0.562000													4	245					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212267	26212267	+	Missense_Mutation	SNP	G	G	A			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chrX:26212267G>A	ENST00000379034.1	+	2	453	c.304G>A	c.(304-306)Gtt>Att	p.V102I		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	102	Ser-rich.									breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						TGATGCCTCCGTTCCTCAGGA	0.522000													10	175					0	0	1	0	0
ZNRD1-AS1	0	broad.mit.edu	37	6	29977327	29977327	+	RNA	SNP	T	T	C	rs143365191	by1000genomes	TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr6:29977327T>C	ENST00000376797.3	-	0	731				HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA																							GACAGCTGCCTTGTGTGGGAC	0.438000													5	91					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39463842	39463842	+	Missense_Mutation	SNP	C	C	A			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr8:39463842C>A	ENST00000265707.5	+	3	194	c.149C>A	c.(148-150)aCa>aAa	p.T50K	ADAM18_ENST00000520772.1_Missense_Mutation_p.T50K|ADAM18_ENST00000541111.1_5'UTR|ADAM18_ENST00000379866.1_Missense_Mutation_p.T50K	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	50					cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			TACATCATTACAATTGATGGA	0.269000													6	18					0.0381472	0.0400546	1	1	0
SIRPA	140885	broad.mit.edu	37	20	1902292	1902292	+	Missense_Mutation	SNP	G	G	A			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr20:1902292G>A	ENST00000358771.4	+	3	840	c.688G>A	c.(688-690)Gtg>Atg	p.V230M	SIRPA_ENST00000356025.3_Missense_Mutation_p.V230M|SIRPA_ENST00000400068.3_Missense_Mutation_p.V230M	NM_001040023.1	NP_001035112.1	P78324	SHPS1_HUMAN	signal-regulatory protein alpha	230	Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding	p.V230M(1)		cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		CATCTGCGAGGTGGCCCACGT	0.612000													4	103					0	0	1	0	0
CLCNKB	1188	broad.mit.edu	37	1	16378296	16378296	+	Silent	SNP	A	A	C			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr1:16378296A>C	ENST00000375679.4	+	14	1500	c.1389A>C	c.(1387-1389)ccA>ccC	p.P463P	CLCNKB_ENST00000375667.3_Silent_p.P294P	NM_000085.4	NP_000076.2			chloride channel, voltage-sensitive Kb											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	21		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		CCATCATGCCAGGGGGGTATG	0.622000													5	102					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625885	29625885	+	Missense_Mutation	SNP	A	A	T			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr20:29625885A>T	ENST00000278882.3	+	5	509	c.129A>T	c.(127-129)aaA>aaT	p.K43N	FRG1B_ENST00000358464.4_Missense_Mutation_p.K43N|FRG1B_ENST00000439954.2_Missense_Mutation_p.K48N														p.K43N(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TCGCCCTGAAATCTGGCTATG	0.353000													4	110					0	0	1	0	0
PGM1	5236	broad.mit.edu	37	1	64114306	64114306	+	Silent	SNP	C	C	T			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr1:64114306C>T	ENST00000371083.4	+	8	1685	c.1317C>T	c.(1315-1317)ggC>ggT	p.G439G	PGM1_ENST00000540265.1_Silent_p.G224G|PGM1_ENST00000371084.3_Silent_p.G421G	NM_001172818.1	NP_001166289.1	P36871	PGM1_HUMAN	phosphoglucomutase 1	421					cellular calcium ion homeostasis|galactose catabolic process|glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20						AAAAGTATGGCCGGAATTTCT	0.547000													32	45					0	0	1	0	0
SIRPA	140885	broad.mit.edu	37	20	1902301	1902301	+	Missense_Mutation	SNP	G	G	A			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr20:1902301G>A	ENST00000358771.4	+	3	849	c.697G>A	c.(697-699)Gtc>Atc	p.V233I	SIRPA_ENST00000356025.3_Missense_Mutation_p.V233I|SIRPA_ENST00000400068.3_Missense_Mutation_p.V233I	NM_001040023.1	NP_001035112.1	P78324	SHPS1_HUMAN	signal-regulatory protein alpha	233	Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding	p.V233I(1)		cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		GGTGGCCCACGTCACCTTGCA	0.617000													4	109					0	0	1	0	0
ZNRD1-AS1	0	broad.mit.edu	37	6	29977342	29977342	+	RNA	SNP	A	A	T	rs116382006	by1000genomes	TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr6:29977342A>T	ENST00000376797.3	-	0	731				HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA																							TGGGACTGAGAGGCAAGATTT	0.438000													5	89					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57570840	57570840	+	Silent	SNP	G	G	A			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr12:57570840G>A	ENST00000243077.3	+	25	4474	c.4008G>A	c.(4006-4008)gaG>gaA	p.E1336E		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	1336					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CTAGTTTCGAGGTGGTGATTC	0.562000													42	98					0	0	1	0	0
SYNRG	11276	broad.mit.edu	37	17	35946585	35946585	+	Missense_Mutation	SNP	G	G	A	rs143289977		TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr17:35946585G>A	ENST00000339208.6	-	4	453	c.313C>T	c.(313-315)Cgt>Tgt	p.R105C	SYNRG_ENST00000585472.1_Missense_Mutation_p.R104C|SYNRG_ENST00000502449.2_Missense_Mutation_p.R105C|SYNRG_ENST00000346661.4_Missense_Mutation_p.R105C|SYNRG_ENST00000394378.2_Missense_Mutation_p.R105C|SYNRG_ENST00000345615.4_Missense_Mutation_p.R105C|SYNRG_ENST00000591288.1_Missense_Mutation_p.R105C	NM_001163544.1|NM_001163545.1|NM_007247.4	NP_001157016.1|NP_001157017.1|NP_009178.3	Q9UMZ2	SYNRG_HUMAN	synergin, gamma	105					endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						CCTGGAGGACGCATGCCCAGG	0.478000													4	121					0	0	1	0	0
GAL3ST2	64090	broad.mit.edu	37	2	242738494	242738496	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr2:242738494_242738496delTCC	ENST00000192314.6	+	2	175_177	c.44_46delTCC	c.(43-48)atc>a	p.IL15del		NM_022134.2	NP_071417.2	Q9H3Q3	G3ST2_HUMAN	galactose-3-O-sulfotransferase 2	15					biosynthetic process	Golgi cisterna membrane|integral to membrane	galactosylceramide sulfotransferase activity	p.L16I(1)		endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|prostate(1)|skin(1)	14		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		TTCCGGGTCATCCTCCTCCTCCT	0.631													7	141	---	---	---	---					
SATB1	6304	broad.mit.edu	37	3	18391133	18391135	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr3:18391133_18391135delCTG	ENST00000338745.6	-	11	3553_3555	c.1819_1821delCAG	c.(1819-1821)del	p.Q607del	TBC1D5_ENST00000414318.2_Intron|SATB1_ENST00000454909.2_In_Frame_Del_p.Q607del|SATB1_ENST00000417717.2_In_Frame_Del_p.Q639del	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	607	Poly-Gln.				cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						GCGGCGGTGCctgctgctgctgc	0.606													8	38	---	---	---	---					
PDS5A	23244	broad.mit.edu	37	4	39899982	39899982	+	Frame_Shift_Del	DEL	A	A	-			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr4:39899982delA	ENST00000503396.1	-	16	2336	c.1797delT	c.(1795-1797)ttfs	p.F599fs	PDS5A_ENST00000303538.8_Intron	NM_001100400.1	NP_001093870.1	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)	0					cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding			breast(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(9)|lung(14)|prostate(3)|skin(1)|urinary_tract(1)	39						AAAGCTAGAGAAAAAGTGTGA	0.323													2	4	---	---	---	---					
PCDH10	57575	broad.mit.edu	37	4	134073569	134073571	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr4:134073569_134073571delCTG	ENST00000264360.4	+	1	3100_3102	c.2274_2276delCTG	c.(2272-2277)ctc>ct	p.LC758del		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	758	Cys-rich.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		ATTGCTGCCTCTGCTGCTGCTGC	0.581													7	91	---	---	---	---					
CCT6P3	0	broad.mit.edu	37	7	64528813	64528814	+	RNA	INS	-	-	T			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr7:64528813_64528814insT	ENST00000426828.1	+	0	621					NR_033416.1																						CTTTCTGTAACTTTTTTTTTTT	0.317													4	5	---	---	---	---					
GPSM1	26086	broad.mit.edu	37	9	139235482	139235482	+	Frame_Shift_Del	DEL	C	C	-			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr9:139235482delC	ENST00000392945.3	+	9	1459	c.1239delC	c.(1237-1239)ctfs	p.L413fs	GPSM1_ENST00000440944.1_Intron	NM_015597.4	NP_056412.4	Q86YR5	GPSM1_HUMAN	G-protein signaling modulator 1	0	Interaction with STK11/LKB1 (By similarity).|Mediates association with membranes (By similarity).				cell differentiation|nervous system development|signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|plasma membrane	binding|GTPase activator activity			biliary_tract(1)|endometrium(1)|kidney(2)|lung(4)|upper_aerodigestive_tract(1)	9		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.39e-06)|Epithelial(140;3.24e-06)		GGGTCTTGCTCCCCACAGGCA	0.687													5	3	---	---	---	---					
KIAA1462	57608	broad.mit.edu	37	10	30316501	30316503	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr10:30316501_30316503delCTG	ENST00000375377.1	-	3	2675_2677	c.2574_2576delCAG	c.(2572-2577)agt>ag	p.SS858del		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	858	Ser-rich.									breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						ACTCTCCTCActgctgctgctgc	0.571													7	138	---	---	---	---					
KNDC1	85442	broad.mit.edu	37	10	135033493	135033493	+	Frame_Shift_Del	DEL	A	A	-			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr10:135033493delA	ENST00000304613.3	+	29	4916	c.4895delA	c.(4894-4896)gafs	p.E1632fs	KNDC1_ENST00000368572.2_Frame_Shift_Del_p.E1634fs			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	1632	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		TGTCTGATGGAAGGGCGGCGC	0.692													2	4	---	---	---	---					
LRRC46	90506	broad.mit.edu	37	17	45909518	45909523	+	In_Frame_Del	DEL	TATCAC	TATCAC	-			TCGA-KS-A41L-01A-11D-A23M-08	TCGA-KS-A41L-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ced601f-7523-4fb2-bdb3-144918e4f86d	0669d6f9-72e7-488f-95df-fd491c730568	g.chr17:45909518_45909523delTATCAC	ENST00000269025.4	+	2	426_431	c.63_68delTATCAC	c.(61-69)ctt>ct	p.LIT21del		NM_033413.3	NP_219481.1	Q96FV0	LRC46_HUMAN	leucine rich repeat containing 46	21										endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)	9						CTGAAGCCCTTATCACTAAGCGGAAC	0.529													8	161	---	---	---	---