Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FLNA	0	broad.mit.edu	37	X	153580679	153580679	+	Silent	SNP	G	G	A			TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chrX:153580679G>A	ENST00000422373.1	-	40	6863	c.6615C>T	c.(6613-6615)agC>agT	p.S2205S	FLNA_ENST00000369850.3_Silent_p.S2213S|FLNA_ENST00000369856.3_Silent_p.S346S|FLNA_ENST00000360319.4_Silent_p.S2205S|FLNA_ENST00000344736.4_Silent_p.S2173S	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	2213					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGTACTTCACGCTGACTGTGT	0.647000													4	32					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102292770	102292770	+	RNA	SNP	C	C	T	rs149751844	by1000genomes	TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chr15:102292770C>T	ENST00000561463.1	+	0	816																											AGCGGCGCGACGAGATGCTGC	0.597000													3	26					0	0	1	0	0
HSP90AA1	3320	broad.mit.edu	37	14	102548619	102548619	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chr14:102548619G>A	ENST00000334701.7	-	11	2565	c.2284C>T	c.(2284-2286)Cat>Tat	p.H762Y	HSP90AA1_ENST00000216281.8_Missense_Mutation_p.H640Y	NM_001017963.2	NP_001017963.2	P07900	HS90A_HUMAN	heat shock protein 90kDa alpha (cytosolic), class A member 1	640					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(6)|large_intestine(3)|liver(1)|lung(10)|ovary(2)|prostate(1)	28					Rifabutin(DB00615)	ATAATGGAATGGTCAGGGTTT	0.448000													6	195					0	0	1	0	0
RNF113A	7737	broad.mit.edu	37	X	119005413	119005413	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chrX:119005413C>T	ENST00000371442.2	-	1	378	c.164G>A	c.(163-165)cGa>cAa	p.R55Q		NM_006978.2	NP_008909.1	O15541	R113A_HUMAN	ring finger protein 113A	55							nucleic acid binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(6)	15						CTTTTCCGGTCGAACCACAGT	0.607000													9	152					0	0	1	0	0
MAN1C1	57134	broad.mit.edu	37	1	26107493	26107493	+	Missense_Mutation	SNP	C	C	A			TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chr1:26107493C>A	ENST00000374332.4	+	10	1870	c.1540C>A	c.(1540-1542)Ctg>Atg	p.L514M	MAN1C1_ENST00000374329.1_Missense_Mutation_p.L285M|MAN1C1_ENST00000263979.3_Missense_Mutation_p.L334M	NM_020379.2	NP_065112.1	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	514					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(7)|pancreas(1)|prostate(1)|skin(2)	25		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		GGCCACCCAGCTGAGCGAGAG	0.612000													4	119					1	1	1	1	0
CARF	79800	broad.mit.edu	37	2	203806639	203806639	+	Missense_Mutation	SNP	A	A	G			TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chr2:203806639A>G	ENST00000320443.8	+	3	1057	c.14A>G	c.(13-15)aAt>aGt	p.N5S	CARF_ENST00000428585.1_Missense_Mutation_p.N5S|CARF_ENST00000545253.1_Intron|CARF_ENST00000444724.1_Missense_Mutation_p.N5S|CARF_ENST00000434998.1_Intron|WDR12_ENST00000477723.1_Intron|CARF_ENST00000471271.1_3'UTR|CARF_ENST00000456821.2_Intron|CARF_ENST00000545262.1_Missense_Mutation_p.N5S|CARF_ENST00000414439.1_Intron|CARF_ENST00000402905.2_Missense_Mutation_p.N5S|CARF_ENST00000438828.2_Missense_Mutation_p.N5S					calcium responsive transcription factor																		GAACAATCTAATGATTCATTA	0.343000													6	78					0	0	1	0	0
C9orf123	0	broad.mit.edu	37	9	7799725	7799725	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chr9:7799725G>A	ENST00000358227.4	-	1	342	c.10C>T	c.(10-12)Cgg>Tgg	p.R4W	C9orf123_ENST00000484082.1_Intron	NM_033428.1	NP_219500.1	Q96GE9	CI123_HUMAN		4						integral to membrane				lung(1)	1		all_cancers(3;0.0539)|Lung NSC(3;3.36e-05)|all_lung(3;0.000156)|all_epithelial(3;0.0356)		GBM - Glioblastoma multiforme(50;0.0561)		TGGGACAACCGAGACCCCATG	0.642000													20	28					0	0	1	0	0
OR5I1	10798	broad.mit.edu	37	11	55702995	55702995	+	Missense_Mutation	SNP	C	C	G			TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chr11:55702995C>G	ENST00000301532.3	-	1	881	c.882G>C	c.(880-882)ttG>ttC	p.L294F		NM_006637.1	NP_006628.1	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I, member 1	294					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(34)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						CTTTATTTCTCAAACTATAAA	0.358000													11	16					0	0	1	0	0
GPR45	11250	broad.mit.edu	37	2	105859266	105859266	+	Silent	SNP	C	C	T			TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chr2:105859266C>T	ENST00000258456.1	+	1	1067	c.951C>T	c.(949-951)tcC>tcT	p.S317S		NM_007227.3	NP_009158.3	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	317						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	28						ACCTCAAGTCCGTCTTCAACC	0.552000													7	135					0	0	1	0	0
LILRB5	0	broad.mit.edu	37	19	54754946	54754946	+	Silent	SNP	G	G	A	rs146755009	by1000genomes	TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chr19:54754946G>A	ENST00000450632.1	-	13	1766	c.1689C>T	c.(1687-1689)ccC>ccT	p.P563P	LILRB5_ENST00000316219.5_Intron|LILRB5_ENST00000449561.2_Intron|LILRB5_ENST00000345866.6_Intron			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	570					cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ACAGTGGGGAGGGAGGAGAGG	0.577000													3	21					0	0	1	0	0
IL17RB	55540	broad.mit.edu	37	3	53898851	53898851	+	Missense_Mutation	SNP	T	T	C			TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chr3:53898851T>C	ENST00000288167.3	+	11	1034	c.1025T>C	c.(1024-1026)aTa>aCa	p.I342T		NM_018725.3	NP_061195.2	Q9NRM6	I17RB_HUMAN	interleukin 17 receptor B	342	SEFIR.				defense response|regulation of cell growth	extracellular region|integral to plasma membrane	cytokine receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)		CCATCTGAAATATGTTTCCAT	0.393000													5	86					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117849425	117849425	+	Silent	SNP	G	G	A			TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chr9:117849425G>A	ENST00000350763.4	-	3	996	c.585C>T	c.(583-585)caC>caT	p.H195H	TNC_ENST00000535648.1_Silent_p.H195H|TNC_ENST00000542877.1_Silent_p.H195H|TNC_ENST00000341037.4_Silent_p.H195H|TNC_ENST00000537320.1_Silent_p.H195H|TNC_ENST00000346706.3_Silent_p.H195H|TNC_ENST00000340094.3_Silent_p.H195H|TNC_ENST00000345230.3_Silent_p.H195H|TNC_ENST00000423613.2_Silent_p.H195H	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	195	EGF-like 2.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						GGCCTCGAAGGTGACAGTTGC	0.622000													51	48					0	0	1	0	0
DCTD	1635	broad.mit.edu	37	4	183815718	183815718	+	Silent	SNP	C	C	T			TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chr4:183815718C>T	ENST00000438320.2	-	4	575	c.285G>A	c.(283-285)tcG>tcA	p.S95S	DCTD_ENST00000357067.3_Silent_p.S106S|DCTD_ENST00000510370.1_Silent_p.S95S	NM_001921.2	NP_001912.2	P32321	DCTD_HUMAN	dCMP deaminase	95				S -> L (in Ref. 6; AAH01286).	nucleotide biosynthetic process|pyrimidine base metabolic process|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide metabolic process	cytosol	dCMP deaminase activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|urinary_tract(1)	18		all_lung(41;5.16e-14)|Lung NSC(41;1.33e-13)|Colorectal(36;0.00666)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.202)		all cancers(43;1.65e-24)|Epithelial(43;3.44e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.39e-10)|Colorectal(24;4.69e-07)|COAD - Colon adenocarcinoma(29;7.07e-05)|STAD - Stomach adenocarcinoma(60;0.000118)|GBM - Glioblastoma multiforme(59;0.000472)|LUSC - Lung squamous cell carcinoma(40;0.00984)|READ - Rectum adenocarcinoma(43;0.0419)		TCACATCGGTCGAATTTTTGT	0.438000													14	33					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46279860	46279860	+	Silent	SNP	G	G	A	rs151060280	byFrequency	TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chr20:46279860G>A	ENST00000372004.3	+	20	3990	c.3774G>A	c.(3772-3774)caG>caA	p.Q1258Q	NCOA3_ENST00000341724.6_Silent_p.Q1188Q|NCOA3_ENST00000371997.3_Silent_p.Q1253Q|NCOA3_ENST00000371998.3_Silent_p.Q1262Q	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	1262	Acetyltransferase.|Poly-Gln.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding	p.Q1262Q(1)		breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						agcagcagcagcagcaacagc	0.567000													4	29					0	0	1	0	0
CEP120	153241	broad.mit.edu	37	5	122717833	122717833	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chr5:122717833C>T	ENST00000306467.5	-	14	2379	c.2075G>A	c.(2074-2076)cGa>cAa	p.R692Q	CEP120_ENST00000328236.5_Missense_Mutation_p.R692Q|CEP120_ENST00000306481.6_Missense_Mutation_p.R666Q			Q8N960	CE120_HUMAN	centrosomal protein 120kDa	692						centrosome				breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	29						TTCTCTTTCTCGGTCCCTTTT	0.363000													22	27					0	0	1	0	0
STIM1	6786	broad.mit.edu	37	11	4107718	4107718	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chr11:4107718C>T	ENST00000300737.4	+	11	2055	c.1486C>T	c.(1486-1488)Cag>Tag	p.Q496*	STIM1_ENST00000527651.1_Nonsense_Mutation_p.Q496*|STIM1_ENST00000533977.1_Nonsense_Mutation_p.Q323*	NM_003156.3	NP_003147.2	Q13586	STIM1_HUMAN	stromal interaction molecule 1	496					activation of store-operated calcium channel activity|calcium ion transport|detection of calcium ion|platelet activation	integral to endoplasmic reticulum membrane|integral to plasma membrane|microtubule	calcium ion binding|microtubule plus-end binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|liver(1)|lung(14)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30		Breast(177;0.00159)|Medulloblastoma(188;0.00258)|all_neural(188;0.0233)		BRCA - Breast invasive adenocarcinoma(625;0.114)|LUSC - Lung squamous cell carcinoma(625;0.141)		CCCTAGCCTGCAGAGCAGTGT	0.587000													4	21					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49440047	49440047	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chr12:49440047C>T	ENST00000301067.7	-	16	4578	c.4579G>A	c.(4579-4581)Gaa>Aaa	p.E1527K		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TCTCACCGTTCACAGTGGCGG	0.542000													12	18					0	0	1	0	0
ERF	2077	broad.mit.edu	37	19	42753122	42753122	+	Missense_Mutation	SNP	G	G	A	rs1063897		TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chr19:42753122G>A	ENST00000222329.4	-	4	1299	c.1142C>T	c.(1141-1143)cCg>cTg	p.P381L	AC006486.9_ENST00000594664.1_Intron|ERF_ENST00000440177.2_Missense_Mutation_p.P306L	NM_006494.2	NP_006485.2	P50548	ERF_HUMAN	Ets2 repressor factor	381				P -> R (in Ref. 1; AAA86686).	cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(1)	17		Prostate(69;0.00682)				GAGTGGGGGCGGCTGGAGCTT	0.692000													11	140					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													3	43					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100369720	100369721	+	RNA	INS	-	-	T			TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chr7:100369720_100369721insT	ENST00000542585.1	+	0	5573				ZAN_ENST00000349350.6_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000449052.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			cctctaaattcttttttttttt	0.535													3	3	---	---	---	---					
PATL1	219988	broad.mit.edu	37	11	59423492	59423492	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chr11:59423492delA	ENST00000300146.9	-	7	834	c.750delT	c.(748-750)ttfs	p.F250fs		NM_152716.2	NP_689929.2	Q86TB9	PATL1_HUMAN	protein associated with topoisomerase II homolog 1 (yeast)	250	Pro-rich.|Region N; interaction with decapping machinery.				cytoplasmic mRNA processing body assembly|deadenylation-dependent decapping of nuclear-transcribed mRNA	cytoplasmic mRNA processing body	protein binding|RNA binding			central_nervous_system(1)|endometrium(2)|lung(5)|ovary(1)|prostate(2)	11						CACTAGGAGGAAAAGGGTGAC	0.438													2	4	---	---	---	---					
GAS6	2621	broad.mit.edu	37	13	114542718	114542718	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chr13:114542718delC	ENST00000357389.3	-	5	601	c.449delG	c.(448-450)gcfs	p.G150fs	GAS6_ENST00000355761.4_Frame_Shift_Del_p.G96fs|GAS6_ENST00000327773.6_Frame_Shift_Del_p.G150fs			Q14393	GAS6_HUMAN	growth arrest-specific 6	150	EGF-like 1; calcium-binding (Potential).				cell proliferation|leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|post-translational protein modification|proteolysis|regulation of growth	endoplasmic reticulum lumen|extracellular space|Golgi lumen|platelet alpha granule lumen	calcium ion binding|receptor agonist activity			central_nervous_system(4)|ovary(1)	5	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0176)|all_epithelial(44;0.0104)|all_lung(25;0.0249)|Lung NSC(25;0.0908)|Breast(118;0.188)				GCAGAGCCGGCCCCCCCAGCC	0.647													7	176	---	---	---	---					
RP11-44F14.1	0	broad.mit.edu	37	16	53403272	53403273	+	RNA	INS	-	-	A			TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chr16:53403272_53403273insA	ENST00000565421.1	-	0	1344_1345																											gactccatctcaaaaaaaaaag	0.436													2	4	---	---	---	---					
RP11-640N20.8	0	broad.mit.edu	37	17	30415976	30415976	+	RNA	DEL	A	A	-			TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chr17:30415976delA	ENST00000581225.1	-	0	151				RP11-640N20.6_ENST00000358484.4_RNA																							ATTGCAGGATAAATCTCTAGG	0.264													2	4	---	---	---	---					
NOTCH3	4854	broad.mit.edu	37	19	15272238	15272238	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ET-A2MX-01A-11D-A23M-08	TCGA-ET-A2MX-11C-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6818a84d-3c69-4a28-b435-cc24bc054277	598b09bc-2542-4146-89d3-fdbb1bbe1f60	g.chr19:15272238delG	ENST00000263388.2	-	33	6276	c.6201delC	c.(6199-6201)ccfs	p.P2067fs		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	2067					Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			ccgccTTCCCGGGGGGCCTCC	0.751													2	4	---	---	---	---