Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
POTEM	641455	broad.mit.edu	37	14	20010235	20010235	+	Missense_Mutation	SNP	A	A	G			TCGA-EM-A1YA-01A-11D-A14W-08	TCGA-EM-A1YA-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e872b54-1efb-4071-ac86-1f53a45dd752	365c3166-e324-47d9-af32-52121df03116	g.chr14:20010235A>G	ENST00000551509.1	-	5	974	c.923T>C	c.(922-924)gTt>gCt	p.V308A	RP11-244H18.1_ENST00000547584.1_lincRNA	NM_001145442.1	NP_001138914.1	A6NI47	POTEM_HUMAN	POTE ankyrin domain family, member M	308										endometrium(4)|kidney(1)|lung(4)	9						AAGTATGAGAACAGTTCTAAA	0.368000													3	45					0	0	0.115264	0	0
DNAH2	146754	broad.mit.edu	37	17	7734055	7734055	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A1YA-01A-11D-A14W-08	TCGA-EM-A1YA-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e872b54-1efb-4071-ac86-1f53a45dd752	365c3166-e324-47d9-af32-52121df03116	g.chr17:7734055G>A	ENST00000572933.1	+	79	13585	c.12125G>A	c.(12124-12126)gGc>gAc	p.G4042D	DNAH2_ENST00000389173.2_Missense_Mutation_p.G4042D			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	4042					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.G4042D(1)		NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CTCATTGCCGGCATCAACTAT	0.507000													3	54					0	0	0.115264	0	0
IARS	3376	broad.mit.edu	37	9	95050407	95050407	+	Splice_Site	SNP	C	C	G			TCGA-EM-A1YA-01A-11D-A14W-08	TCGA-EM-A1YA-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e872b54-1efb-4071-ac86-1f53a45dd752	365c3166-e324-47d9-af32-52121df03116	g.chr9:95050407C>G	ENST00000375643.3	-	3	543		c.e3+1		IARS_ENST00000443024.2_Splice_Site|IARS_ENST00000447699.2_Intron|IARS_ENST00000375629.3_Splice_Site	NM_013417.2	NP_038203.2	P41252	SYIC_HUMAN	isoleucyl-tRNA synthetase						isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	35					L-Isoleucine(DB00167)	CTCAAACATACCACAGGTAAG	0.348000													3	54					0	0	0.115264	0	0
PSG9	5678	broad.mit.edu	37	19	43766171	43766171	+	Missense_Mutation	SNP	C	C	A			TCGA-EM-A1YA-01A-11D-A14W-08	TCGA-EM-A1YA-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e872b54-1efb-4071-ac86-1f53a45dd752	365c3166-e324-47d9-af32-52121df03116	g.chr19:43766171C>A	ENST00000244293.7	-	3	616	c.550G>T	c.(550-552)Ggt>Tgt	p.G184C	PSG9_ENST00000593948.1_Missense_Mutation_p.G184C|PSG9_ENST00000443718.3_Intron|PSG9_ENST00000291752.5_Intron|PSG9_ENST00000270077.3_Missense_Mutation_p.G184C|PSG9_ENST00000418820.2_Intron|PSG9_ENST00000596730.1_Intron			Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	184	Ig-like C2-type 1.				female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				AGGCTCTGACCATTCATCCAC	0.507000													109	165					3.29639e-60	3.86967e-60	0.139131	1	0
EIF1AX	1964	broad.mit.edu	37	X	20148725	20148725	+	Splice_Site	SNP	G	G	A			TCGA-EM-A1YA-01A-11D-A14W-08	TCGA-EM-A1YA-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e872b54-1efb-4071-ac86-1f53a45dd752	365c3166-e324-47d9-af32-52121df03116	g.chrX:20148725G>A	ENST00000379607.5	-	6	541	c.337_splice	c.e6-1	p.A113_splice	EIF1AX_ENST00000379593.1_Splice_Site_p.A85_splice	NM_001412.3	NP_001403.1	P47813	IF1AX_HUMAN	eukaryotic translation initiation factor 1A, X-linked	113						cytosol	translation initiation factor activity			endometrium(2)|lung(1)|ovary(1)|prostate(1)	5						ATTGATTTTAGCTAAGGACAC	0.313000													22	41					0	0	0.062417	0	0
SLC10A5	347051	broad.mit.edu	37	8	82606560	82606560	+	Silent	SNP	T	T	A			TCGA-EM-A1YA-01A-11D-A14W-08	TCGA-EM-A1YA-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e872b54-1efb-4071-ac86-1f53a45dd752	365c3166-e324-47d9-af32-52121df03116	g.chr8:82606560T>A	ENST00000518568.1	-	1	1849	c.648A>T	c.(646-648)ccA>ccT	p.P216P		NM_001010893.2	NP_001010893.1	Q5PT55	NTCP5_HUMAN	solute carrier family 10, member 5	216						integral to membrane	bile acid:sodium symporter activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)	15						CACCCCCTCCTGGGCACGTGC	0.468000													42	73					0	0	0.104719	0	0
ENPP1	5167	broad.mit.edu	37	6	132171195	132171195	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A1YA-01A-11D-A14W-08	TCGA-EM-A1YA-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e872b54-1efb-4071-ac86-1f53a45dd752	365c3166-e324-47d9-af32-52121df03116	g.chr6:132171195G>A	ENST00000360971.2	+	3	399	c.379G>A	c.(379-381)Gtt>Att	p.V127I		NM_006208.2	NP_006199.2	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 1	127	SMB 1.				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(22)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	46	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	TGCTGCCTGTGTTGAGCTTGG	0.413000													9	89					0	0	0.069234	0	0
IGSF22	283284	broad.mit.edu	37	11	18731052	18731052	+	Nonsense_Mutation	SNP	G	G	C			TCGA-EM-A1YA-01A-11D-A14W-08	TCGA-EM-A1YA-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e872b54-1efb-4071-ac86-1f53a45dd752	365c3166-e324-47d9-af32-52121df03116	g.chr11:18731052G>C	ENST00000513874.1	-	18	3019	c.2880C>G	c.(2878-2880)taC>taG	p.Y960*	RP11-1081L13.4_ENST00000527285.1_RNA	NM_173588.3	NP_775859.3	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	859										NS(2)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(20)|ovary(4)|prostate(4)|skin(3)	56						CTCCCACTGTGTAGCAGGTGC	0.567000													4	102					0	0	0.150653	0	0
ALPK1	80216	broad.mit.edu	37	4	113362205	113362205	+	Missense_Mutation	SNP	A	A	G			TCGA-EM-A1YA-01A-11D-A14W-08	TCGA-EM-A1YA-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e872b54-1efb-4071-ac86-1f53a45dd752	365c3166-e324-47d9-af32-52121df03116	g.chr4:113362205A>G	ENST00000458497.1	+	15	3950	c.3671A>G	c.(3670-3672)gAa>gGa	p.E1224G	ALPK1_ENST00000504176.2_Missense_Mutation_p.E1146G|ALPK1_ENST00000177648.9_Missense_Mutation_p.E1224G	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	1224	Alpha-type protein kinase.						ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		CAGCATGTGGAATGTAATGAA	0.383000													56	121					0	0	0.139131	0	0
EIF1AX	1964	broad.mit.edu	37	X	20148726	20148726	+	Splice_Site	SNP	C	C	A			TCGA-EM-A1YA-01A-11D-A14W-08	TCGA-EM-A1YA-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e872b54-1efb-4071-ac86-1f53a45dd752	365c3166-e324-47d9-af32-52121df03116	g.chrX:20148726C>A	ENST00000379607.5	-	6	541		c.e6-1		EIF1AX_ENST00000379593.1_Splice_Site	NM_001412.3	NP_001403.1	P47813	IF1AX_HUMAN	eukaryotic translation initiation factor 1A, X-linked							cytosol	translation initiation factor activity			endometrium(2)|lung(1)|ovary(1)|prostate(1)	5						TTGATTTTAGCTAAGGACACA	0.313000													21	42					6.33239e-15	7.12393e-15	0.055883	1	0
AMZ2P1	0	broad.mit.edu	37	17	62968690	62968690	+	RNA	SNP	A	A	G	rs138671696	by1000genomes	TCGA-EM-A1YA-01A-11D-A14W-08	TCGA-EM-A1YA-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e872b54-1efb-4071-ac86-1f53a45dd752	365c3166-e324-47d9-af32-52121df03116	g.chr17:62968690A>G	ENST00000430983.1	-	0	1554					NR_026903.1																						AAAATTCCACAAGTCTCTTGG	0.373000													5	108					0	0	0.014758	0	0
RGPD8	727851	broad.mit.edu	37	2	113174792	113174792	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A1YA-01A-11D-A14W-08	TCGA-EM-A1YA-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e872b54-1efb-4071-ac86-1f53a45dd752	365c3166-e324-47d9-af32-52121df03116	g.chr2:113174792C>T	ENST00000302558.3	-	6	951	c.760G>A	c.(760-762)Gaa>Aaa	p.E254K	RGPD8_ENST00000409750.1_Intron|RGPD8_ENST00000330575.5_Missense_Mutation_p.E254K	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8											endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						TCTCTATTTTCCTGCACATCT	0.388000													56	102					0	0	0.139131	0	0
PKM	5315	broad.mit.edu	37	15	72495521	72495521	+	Silent	SNP	A	A	G			TCGA-EM-A1YA-01A-11D-A14W-08	TCGA-EM-A1YA-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e872b54-1efb-4071-ac86-1f53a45dd752	365c3166-e324-47d9-af32-52121df03116	g.chr15:72495521A>G	ENST00000319622.6	-	9	1605	c.1149T>C	c.(1147-1149)cgT>cgC	p.R383R	PKM_ENST00000335181.5_Intron|PKM_ENST00000449901.2_Intron|PKM_ENST00000568459.1_Silent_p.R383R|PKM_ENST00000568883.1_Silent_p.R218R|PKM_ENST00000389093.3_Silent_p.R383R|PKM_ENST00000565154.1_Silent_p.R383R|PKM_ENST00000565184.1_Silent_p.R383R	NM_001206796.1|NM_182470.2|NM_182471.2	NP_001193725.1|NP_872270.1|NP_872271.1			pyruvate kinase, muscle											endometrium(1)|lung(7)	8						CCTCAGCCTCACGAGCTATCT	0.527000													3	42					0	0	0.115264	0	0
SPRED2	200734	broad.mit.edu	37	2	65540763	65540763	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A1YA-01A-11D-A14W-08	TCGA-EM-A1YA-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e872b54-1efb-4071-ac86-1f53a45dd752	365c3166-e324-47d9-af32-52121df03116	g.chr2:65540763G>A	ENST00000356388.4	-	6	1318	c.1129C>T	c.(1129-1131)Cgg>Tgg	p.R377W	SPRED2_ENST00000443619.2_Missense_Mutation_p.R374W	NM_181784.2	NP_861449.2	Q7Z698	SPRE2_HUMAN	sprouty-related, EVH1 domain containing 2	377	SPR.				inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(7)|ovary(2)|upper_aerodigestive_tract(3)	34						GCCATCCACCGGAGGCAAAAC	0.577000													3	34					0	0	0.115264	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19666639	19666639	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A1YA-01A-11D-A14W-08	TCGA-EM-A1YA-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e872b54-1efb-4071-ac86-1f53a45dd752	365c3166-e324-47d9-af32-52121df03116	g.chr21:19666639C>T	ENST00000284885.3	-	21	2467	c.2434G>A	c.(2434-2436)Gca>Aca	p.A812T		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	812	Peptidase S1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						ACGAGAGATGCGCCGCAGAGC	0.567000													5	64					0	0	0.014758	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45128762	45128762	+	RNA	SNP	T	T	C	rs8066232	by1000genomes	TCGA-EM-A1YA-01A-11D-A14W-08	TCGA-EM-A1YA-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e872b54-1efb-4071-ac86-1f53a45dd752	365c3166-e324-47d9-af32-52121df03116	g.chr17:45128762T>C	ENST00000575173.1	-	0	418																											TTCTGCCTCATTGTGGTAAGG	0.368000													3	62					0	0	0.115264	0	0
AC008103.5	0	broad.mit.edu	37	22	18844900	18844900	+	RNA	SNP	C	C	T			TCGA-EM-A1YA-01A-11D-A14W-08	TCGA-EM-A1YA-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e872b54-1efb-4071-ac86-1f53a45dd752	365c3166-e324-47d9-af32-52121df03116	g.chr22:18844900C>T	ENST00000412938.1	+	0	3150																											ACAGCTTCAGCGTGCCTGCGA	0.577000													7	38					0	0	0.038147	0	0
RP11-551L14.1	0	broad.mit.edu	37	12	31269189	31269190	+	RNA	INS	-	-	ATCAT	rs35880498		TCGA-EM-A1YA-01A-11D-A14W-08	TCGA-EM-A1YA-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e872b54-1efb-4071-ac86-1f53a45dd752	365c3166-e324-47d9-af32-52121df03116	g.chr12:31269189_31269190insATCAT	ENST00000542490.1	-	0	165																				central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(25)|prostate(3)|stomach(3)|urinary_tract(1)	41						CATGAGAACTCATTACCATGAT	0.351													5	7	---	---	---	---