Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LONRF2	164832	broad.mit.edu	37	2	100903492	100903492	+	Missense_Mutation	SNP	G	G	C			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr2:100903492G>C	ENST00000393437.3	-	11	2593	c.1954C>G	c.(1954-1956)Ctc>Gtc	p.L652V	LONRF2_ENST00000409647.1_Missense_Mutation_p.L409V	NM_198461.3	NP_940863.3	Q1L5Z9	LONF2_HUMAN	LON peptidase N-terminal domain and ring finger 2	652	Lon.				proteolysis		ATP-dependent peptidase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	34						GAATCGTGGAGAGCGGCAAGT	0.488000													3	35					0	0	0.115264	0	0
EPPK1	83481	broad.mit.edu	37	8	144940615	144940615	+	Silent	SNP	G	G	A			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr8:144940615G>A	ENST00000525985.1	-	2	6878	c.6807C>T	c.(6805-6807)acC>acT	p.T2269T				P58107	EPIPL_HUMAN	epiplakin 1	2269						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGACGAAGCCGGTGGCCGCCT	0.716000													7	55					0	0	0.248553	0	0
SHROOM3	57619	broad.mit.edu	37	4	77700311	77700311	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr4:77700311C>T	ENST00000296043.6	+	11	6925	c.5972C>T	c.(5971-5973)aCa>aTa	p.T1991I	RP11-359D14.3_ENST00000449007.1_RNA	NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	1991					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			ATTTTCCCAACATTAACCTCT	0.448000													4	51					0	0	0.150653	0	0
PCDH9	5101	broad.mit.edu	37	13	67801027	67801027	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr13:67801027C>T	ENST00000544246.1	-	2	2237	c.1546G>A	c.(1546-1548)Gat>Aat	p.D516N	PCDH9_ENST00000377865.2_Missense_Mutation_p.D516N|PCDH9_ENST00000377861.3_Missense_Mutation_p.D516N|PCDH9_ENST00000456367.1_Missense_Mutation_p.D516N|PCDH9_ENST00000328454.5_Missense_Mutation_p.D516N	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	516	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		CGGTCCAGATCAAAGAAGGAG	0.433000													4	80					0	0	0.150653	0	0
AP3B1	8546	broad.mit.edu	37	5	77452177	77452177	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr5:77452177C>T	ENST00000255194.6	-	14	1553	c.1378G>A	c.(1378-1380)Gaa>Aaa	p.E460K	AP3B1_ENST00000519295.1_Missense_Mutation_p.E411K	NM_001271769.1	NP_001258698.1	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1 subunit	460					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(12)|lung(12)|prostate(1)|skin(2)|urinary_tract(1)	39		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		ACCACACTTTCAGCAACAACT	0.299000									Hermansky-Pudlak syndrome				7	76					0	0	0.278610	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													3	86					0	0	0.115264	0	0
PSG4	5672	broad.mit.edu	37	19	43702160	43702160	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr19:43702160A>G	ENST00000405312.3	-	3	935	c.698T>C	c.(697-699)cTg>cCg	p.L233P	PSG4_ENST00000433626.2_Intron|PSG4_ENST00000244295.9_Missense_Mutation_p.L233P	NM_002780.3	NP_002771.2	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4	233	Ig-like C2-type 1.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	24		Prostate(69;0.00682)				GAGGAGATTCAGGGTGACTGG	0.527000													5	300					0	0	0.217242	0	0
ABCB7	22	broad.mit.edu	37	X	74293735	74293735	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chrX:74293735G>T	ENST00000253577.3	-	7	939	c.915C>A	c.(913-915)taC>taA	p.Y305*	ABCB7_ENST00000534570.1_5'UTR|ABCB7_ENST00000373394.3_Nonsense_Mutation_p.Y304*|ABCB7_ENST00000339447.4_Nonsense_Mutation_p.Y264*	NM_001271696.1|NM_004299.3	NP_001258625.1|NP_004290.2	O75027	ABCB7_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 7	304	ABC transmembrane type-1.				cellular iron ion homeostasis	integral to membrane|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|heme transporter activity			breast(1)|endometrium(5)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)	20						TGAATGCTGTGTATGTACCAA	0.373000													4	55					0.00909568	0.0104738	0.150653	1	0
LRP5	4041	broad.mit.edu	37	11	68181159	68181159	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr11:68181159C>T	ENST00000294304.7	+	12	2612	c.2506C>T	c.(2506-2508)Cag>Tag	p.Q836*		NM_002335.2	NP_002326.2	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein 5	836	Beta-propeller 3.				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TCATGCAGGTCAGGAGCGGGT	0.607000													4	50					0	0	0.150653	0	0
EGFLAM	133584	broad.mit.edu	37	5	38451448	38451448	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr5:38451448A>G	ENST00000322350.5	+	19	2921	c.2575A>G	c.(2575-2577)Agg>Ggg	p.R859G	EGFLAM_ENST00000336740.6_Missense_Mutation_p.R625G|EGFLAM_ENST00000354891.3_Missense_Mutation_p.R867G|EGFLAM_ENST00000397202.2_Missense_Mutation_p.R225G|EGFLAM_ENST00000514476.1_Missense_Mutation_p.R2G|EGFLAM_ENST00000506135.1_Missense_Mutation_p.R2G|EGFLAM_ENST00000397210.3_Missense_Mutation_p.R2G	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	867	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					TGTGTTCATGAGGTTTAAAAC	0.473000													3	100					0	0	0.115264	0	0
USP46	64854	broad.mit.edu	37	4	53492228	53492228	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr4:53492228T>C	ENST00000441222.2	-	4	702	c.518A>G	c.(517-519)cAg>cGg	p.Q173R	USP46_ENST00000451218.2_Missense_Mutation_p.Q146R|USP46_ENST00000508499.1_Missense_Mutation_p.Q166R	NM_022832.3	NP_073743.2	P62068	UBP46_HUMAN	ubiquitin specific peptidase 46	173					behavior|protein deubiquitination|regulation of synaptic transmission, GABAergic|ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(2)	12			LUSC - Lung squamous cell carcinoma(32;0.0295)			AAGCGTTCCCTGAAAAATCTC	0.383000													3	56					0	0	0.150653	0	0
PIK3CB	5291	broad.mit.edu	37	3	138374244	138374244	+	Missense_Mutation	SNP	T	T	A			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr3:138374244T>A	ENST00000477593.1	-	23	3273	c.3200A>T	c.(3199-3201)gAc>gTc	p.D1067V	PIK3CB_ENST00000289153.2_Missense_Mutation_p.D1067V|PIK3CB_ENST00000544716.1_Missense_Mutation_p.D518V			P42338	PK3CB_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	1067	PI3K/PI4K.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.D1067V(1)		NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	41						AGATCTGTAGTCTTTCCGAAC	0.408000													5	65					0	0	0.184627	0	0
KRTAP4-8	728224	broad.mit.edu	37	17	39254054	39254054	+	Missense_Mutation	SNP	A	A	T	rs76270529	by1000genomes	TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr17:39254054A>T	ENST00000333822.4	-	1	339	c.283T>A	c.(283-285)Tgc>Agc	p.C95S		NM_031960.2	NP_114166.1	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4-8	95	25 X 5 AA repeats of C-C-[IKRQVHEC]- [SPRT]-[STCVQPR].					keratin filament		p.C95S(4)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|prostate(1)	11						ctggagatgcagcagcTAGGG	0.677000													7	42					0	0	0.278610	0	0
OR2G6	391211	broad.mit.edu	37	1	248685767	248685767	+	Missense_Mutation	SNP	G	G	T			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr1:248685767G>T	ENST00000343414.4	+	1	852	c.820G>T	c.(820-822)Gtt>Ttt	p.V274F		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	274					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGGAAAGTTTGTTTCTCTTTT	0.438000													9	73					0.000442599	0.000525587	0.335167	1	0
ZFHX3	463	broad.mit.edu	37	16	72829670	72829670	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr16:72829670T>C	ENST00000268489.5	-	9	7583	c.6911A>G	c.(6910-6912)cAg>cGg	p.Q2304R	ZFHX3_ENST00000397992.5_Missense_Mutation_p.Q1390R	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	2304					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				GCCCTCTCCCTGATTCTCATA	0.443000													3	129					0	0	0.115264	0	0
MKI67	4288	broad.mit.edu	37	10	129905423	129905423	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr10:129905423T>C	ENST00000368654.3	-	13	5056	c.4681A>G	c.(4681-4683)Aaa>Gaa	p.K1561E	MKI67_ENST00000368653.3_Missense_Mutation_p.K1201E	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	1561	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				AGGTCCAGTTTCTGCACTGGA	0.493000													17	192					0	0	0.520397	0	0
FZD8	8325	broad.mit.edu	37	10	35930194	35930194	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr10:35930194T>C	ENST00000374694.1	-	1	168	c.164A>G	c.(163-165)aAt>aGt	p.N55S		NM_031866.2	NP_114072.1	Q9H461	FZD8_HUMAN	frizzled family receptor 8	55	FZ.				axonogenesis|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|T cell differentiation in thymus|vasculature development	cell projection|Golgi apparatus|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	11						GTTGAACTGATTGGGCATGTA	0.617000													3	33					0	0	0.115264	0	0
MGAT5B	146664	broad.mit.edu	37	17	74878302	74878302	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr17:74878302G>A	ENST00000569840.2	+	3	825	c.251G>A	c.(250-252)cGc>cAc	p.R84H	MGAT5B_ENST00000301618.4_Missense_Mutation_p.R84H|MGAT5B_ENST00000565675.1_Missense_Mutation_p.R84H|MGAT5B_ENST00000428789.2_Missense_Mutation_p.R95H|MGAT5B_ENST00000374998.3_3'UTR	NM_001199172.1	NP_001186101.1	Q3V5L5	MGT5B_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B	84						Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(15)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						ATGGTGAAGCGCATGGACGCA	0.672000													6	21					0	0	0.278610	0	0
RTKN	6242	broad.mit.edu	37	2	74656958	74656958	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr2:74656958A>G	ENST00000305557.5	-	7	1298	c.713T>C	c.(712-714)gTt>gCt	p.V238A	RTKN_ENST00000233330.6_Missense_Mutation_p.V201A|RTKN_ENST00000272430.5_Missense_Mutation_p.V251A	NM_033046.2	NP_149035.1	Q9BST9	RTKN_HUMAN	rhotekin	251					apoptosis|regulation of anti-apoptosis|Rho protein signal transduction	intracellular	GTP binding|GTP-Rho binding|GTPase inhibitor activity			endometrium(3)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(1)	16						GCCTTACCCAACAACTGGGGT	0.602000													4	43					0	0	0.150653	0	0
LPPR1	0	broad.mit.edu	37	9	104071536	104071536	+	Silent	SNP	C	C	T			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr9:104071536C>T	ENST00000374874.3	+	5	868	c.429C>T	c.(427-429)aaC>aaT	p.N143N	LPPR1_ENST00000395056.2_Silent_p.N143N	NM_207299.1	NP_997182.1	Q8TBJ4	LPPR1_HUMAN		143						integral to membrane	catalytic activity										TTTTTGTAAACGCCGGACAAG	0.418000													9	71					0	0	0.307466	0	0
AP3B1	8546	broad.mit.edu	37	5	77452176	77452176	+	Missense_Mutation	SNP	T	T	A			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr5:77452176T>A	ENST00000255194.6	-	14	1554	c.1379A>T	c.(1378-1380)gAa>gTa	p.E460V	AP3B1_ENST00000519295.1_Missense_Mutation_p.E411V	NM_001271769.1	NP_001258698.1	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1 subunit	460					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(12)|lung(12)|prostate(1)|skin(2)|urinary_tract(1)	39		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		AACCACACTTTCAGCAACAAC	0.299000									Hermansky-Pudlak syndrome				7	76					0	0	0.278610	0	0
WDR49	151790	broad.mit.edu	37	3	167245799	167245799	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr3:167245799A>G	ENST00000308378.3	-	11	1662	c.1357T>C	c.(1357-1359)Tgt>Cgt	p.C453R	WDR49_ENST00000476376.1_Missense_Mutation_p.C278R|WDR49_ENST00000453925.2_Intron|WDR49_ENST00000479765.1_Intron	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	453										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						GAGTTAAGACAGTACTCCTGA	0.353000													7	37					0	0	0.278610	0	0
AC093642.5	0	broad.mit.edu	37	2	243037115	243037115	+	RNA	SNP	A	A	G			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr2:243037115A>G	ENST00000456398.1	+	0	247																											GGCTGGAAGAATTGTGAATCT	0.398000													3	70					0	0	0.278610	0	0
DUSP13	0	broad.mit.edu	37	10	76868831	76868831	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr10:76868831G>A	ENST00000372702.3	-	1	148	c.85C>T	c.(85-87)Cgg>Tgg	p.R29W	DUSP13_ENST00000491677.2_5'UTR|DUSP13_ENST00000607131.1_5'UTR|DUSP13_ENST00000607009.1_5'UTR|DUSP13_ENST00000372700.3_Missense_Mutation_p.R29W			Q6B8I1	MDSP_HUMAN	dual specificity phosphatase 13	29						cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	8	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					TTCCCTGCCCGCAGGAGCTCC	0.642000													3	39					0	0	0.150653	0	0
DOCK10	55619	broad.mit.edu	37	2	225739448	225739448	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr2:225739448T>C	ENST00000409592.3	-	9	1047	c.934A>G	c.(934-936)Act>Gct	p.T312A	DOCK10_ENST00000258390.7_Missense_Mutation_p.T318A			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	318							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CATTCACAAGTTACAGAATTA	0.373000													11	114					0	0	0.411799	0	0
POTEC	388468	broad.mit.edu	37	18	14513675	14513675	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr18:14513675T>C	ENST00000358970.5	-	10	1518	c.1519A>G	c.(1519-1521)Aaa>Gaa	p.K507E		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	507								p.K507E(2)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						GAATTCATTTTCTTTTCAGCC	0.284000													3	95					0	0	0.115264	0	0
PTPRN	5798	broad.mit.edu	37	2	220162111	220162111	+	Silent	SNP	C	C	G			TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr2:220162111C>G	ENST00000295718.2	-	14	2172	c.1932G>C	c.(1930-1932)cgG>cgC	p.R644R	PTPRN_ENST00000423636.2_Silent_p.R554R|PTPRN_ENST00000409251.3_Silent_p.R615R	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	644					response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		GACCCTCTGCCCGGTTGAACA	0.627000													6	56					0	0	0.248553	0	0
POLDIP2	26073	broad.mit.edu	37	17	26684394	26684395	+	Splice_Site	INS	-	-	G	rs113730440		TCGA-DJ-A2Q9-01A-21D-A18F-08	TCGA-DJ-A2Q9-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adf1cfbc-98f6-4cab-9dd2-adbc4b68563d	fa3be43f-26a6-4058-bf98-43f73d552719	g.chr17:26684394_26684395insG	ENST00000540200.1	-	1	78		c.e1+1		POLDIP2_ENST00000003607.4_5'UTR	NM_015584.3	NP_056399.1	Q9Y2S7	PDIP2_HUMAN	polymerase (DNA-directed), delta interacting protein 2							mitochondrial nucleoid|nucleus						all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		AGAGCGGCTTTGCCACCGGGCC	0.762													9	8	---	---	---	---