Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TMED8	283578	broad.mit.edu	37	14	77812725	77812725	+	Missense_Mutation	SNP	C	C	A			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr14:77812725C>A	ENST00000216468.7	-	3	349	c.294G>T	c.(292-294)ttG>ttT	p.L98F		NM_213601.1	NP_998766.1	Q6PL24	TMED8_HUMAN	transmembrane emp24 protein transport domain containing 8	98					transport	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)	15			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)		CTGCAGGCAGCAAATCCTGTT	0.537000													3	65					0.004672	0.00517708	0.115264	1	0
CNTNAP3	79937	broad.mit.edu	37	9	39171422	39171422	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr9:39171422C>T	ENST00000297668.6	-	8	1350	c.1277G>A	c.(1276-1278)gGc>gAc	p.G426D	CNTNAP3_ENST00000377659.1_Missense_Mutation_p.G426D|CNTNAP3_ENST00000377656.2_Missense_Mutation_p.G426D|CNTNAP3_ENST00000323947.7_Missense_Mutation_p.G426D|CNTNAP3_ENST00000358144.2_Missense_Mutation_p.G338D	NM_033655.3	NP_387504.2	Q9BZ76	CNTP3_HUMAN	contactin associated protein-like 3	426	Laminin G-like 2.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	24				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TTTGAGCTTGCCATCCTTAAG	0.468000													4	145					0	0	0.009096	0	0
BMS1	9790	broad.mit.edu	37	10	43318593	43318593	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr10:43318593G>A	ENST00000374518.4	+	20	3223	c.3160G>A	c.(3160-3162)Gcc>Acc	p.A1054T		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor	1054					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						CTTGGAAGTGGCCAAATTTGA	0.423000													4	146					0	0	0.014758	0	0
HCRTR1	3061	broad.mit.edu	37	1	32092570	32092570	+	Missense_Mutation	SNP	G	G	T			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr1:32092570G>T	ENST00000403528.2	+	9	1652	c.1267G>T	c.(1267-1269)Gtg>Ttg	p.V423L	HCRTR1_ENST00000373705.1_Intron|HCRTR1_ENST00000468521.1_Intron|HCRTR1_ENST00000373706.5_Missense_Mutation_p.V423L	NM_001525.2	NP_001516.2	O43613	OX1R_HUMAN	hypocretin (orexin) receptor 1	423					feeding behavior|neuropeptide signaling pathway|synaptic transmission	integral to plasma membrane				breast(2)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	7		Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.053)		CGTCACCACAGTGCTGCCCTG	0.612000													4	147					0.000602214	0.000685855	0.014758	1	0
COL16A1	1307	broad.mit.edu	37	1	32138037	32138037	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr1:32138037G>A	ENST00000373672.3	-	47	3601	c.3085C>T	c.(3085-3087)Cca>Tca	p.P1029S	COL16A1_ENST00000271069.6_Missense_Mutation_p.P1029S	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	1029	Triple-helical region 2 (COL2) with 2 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		CTCTGGCCTGGCAATCCCGGA	0.607000													4	167					0	0	0.009096	0	0
TSSC2	0	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													6	72					0	0	0.021553	0	0
FGR	2268	broad.mit.edu	37	1	27949582	27949582	+	Silent	SNP	C	C	T			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr1:27949582C>T	ENST00000374005.3	-	4	588	c.300G>A	c.(298-300)aaG>aaA	p.K100K	FGR_ENST00000399173.1_Silent_p.K100K|FGR_ENST00000374004.1_Silent_p.K100K|FGR_ENST00000545953.1_Silent_p.K100K	NM_005248.2	NP_005239.1	P09769	FGR_HUMAN	feline Gardner-Rasheed sarcoma viral oncogene homolog	100	SH3.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		ACTTCTCGCCCTTGGTGAAGG	0.552000													9	48					0	0	0.069234	0	0
ZFAND5	0	broad.mit.edu	37	9	74975033	74975033	+	Missense_Mutation	SNP	T	T	G			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr9:74975033T>G	ENST00000237937.3	-	3	813	c.256A>C	c.(256-258)Aaa>Caa	p.K86Q	ZFAND5_ENST00000343431.2_Missense_Mutation_p.K86Q|ZFAND5_ENST00000488164.1_5'UTR|ZFAND5_ENST00000376960.4_Missense_Mutation_p.K86Q|ZFAND5_ENST00000376962.5_Missense_Mutation_p.K86Q	NM_001102421.1|NM_001278243.1|NM_001278244.1|NM_001278245.1|NM_006007.2	NP_001095891.1|NP_001265172.1|NP_001265173.1|NP_001265174.1|NP_005998.1	O76080	ZFAN5_HUMAN	zinc finger, AN1-type domain 5	86							DNA binding|zinc ion binding			cervix(1)|kidney(2)|lung(2)|prostate(1)	6						TACCTTGATTTTTCAGATGTG	0.393000													4	95					0	0	0.009096	0	0
PFKFB3	5209	broad.mit.edu	37	10	6268161	6268161	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr10:6268161A>G	ENST00000379775.4	+	14	1678	c.1348A>G	c.(1348-1350)Aag>Gag	p.K450E	PFKFB3_ENST00000379789.4_Missense_Mutation_p.K430E|PFKFB3_ENST00000317350.4_Missense_Mutation_p.K450E|PFKFB3_ENST00000360521.2_Missense_Mutation_p.K450E|PFKFB3_ENST00000379785.1_Missense_Mutation_p.K450E|PFKFB3_ENST00000536985.1_3'UTR|PFKFB3_ENST00000379782.3_Missense_Mutation_p.K450E|PFKFB3_ENST00000540253.1_Missense_Mutation_p.K464E	NM_004566.3	NP_004557.1	Q16875	F263_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	450	Fructose-2,6-bisphosphatase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|liver(2)|lung(10)|ovary(3)|upper_aerodigestive_tract(1)	22						TTAGGATGCAAAGAAGGGACC	0.483000													4	154					0	0	0.021553	0	0
LILRB3	11025	broad.mit.edu	37	19	54722660	54722660	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr19:54722660C>T	ENST00000391750.1	-	10	1610	c.1474G>A	c.(1474-1476)Gag>Aag	p.E492K	LILRA6_ENST00000270464.5_Missense_Mutation_p.E492K|LILRB3_ENST00000346401.6_Missense_Mutation_p.E504K|LILRA6_ENST00000391735.3_3'UTR|LILRB3_ENST00000245620.9_Missense_Mutation_p.E492K|LILRB3_ENST00000469273.1_5'UTR|LILRB3_ENST00000407860.2_Missense_Mutation_p.E509K|LILRB3_ENST00000424807.1_Missense_Mutation_p.E492K|LILRA6_ENST00000440558.2_Missense_Mutation_p.E492K|LILRA6_ENST00000419410.2_Missense_Mutation_p.E492K			O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	492					cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			endometrium(3)|kidney(13)|large_intestine(1)|lung(6)|ovary(2)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	34	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCCTTGGGCTCTGTCTCCGCA	0.577000													4	113					0	0	0.009096	0	0
TSPAN15	23555	broad.mit.edu	37	10	71243586	71243586	+	Missense_Mutation	SNP	T	T	C	rs140708891	byFrequency	TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr10:71243586T>C	ENST00000373290.2	+	2	358	c.236T>C	c.(235-237)aTt>aCt	p.I79T		NM_012339.3	NP_036471.1	O95858	TSN15_HUMAN	tetraspanin 15	79						integral to plasma membrane|membrane fraction				breast(1)|endometrium(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)	9						GTCTCCTTCATTGGTGTGCTG	0.587000													4	96					0	0	0.014758	0	0
CYP26B1	56603	broad.mit.edu	37	2	72362423	72362423	+	Silent	SNP	C	C	T			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr2:72362423C>T	ENST00000001146.2	-	3	758	c.555G>A	c.(553-555)gcG>gcA	p.A185A	CYP26B1_ENST00000546307.1_Silent_p.A110A|CYP26B1_ENST00000412253.1_5'UTR	NM_001277742.1|NM_019885.2	NP_001264671.1|NP_063938.1	Q9NR63	CP26B_HUMAN	cytochrome P450, family 26, subfamily B, polypeptide 1	185			A -> V.		cell fate determination|embryonic limb morphogenesis|male meiosis|negative regulation of retinoic acid receptor signaling pathway|proximal/distal pattern formation|retinoic acid catabolic process|spermatogenesis|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			breast(1)|kidney(3)|large_intestine(2)|lung(16)|ovary(2)|prostate(2)|skin(2)	28						TCAGCTTCTGCGCCTCCTGGT	0.622000													5	184					0	0	0.021553	0	0
RNF139	11236	broad.mit.edu	37	8	125499517	125499517	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr8:125499517A>G	ENST00000303545.3	+	2	1999	c.1627A>G	c.(1627-1629)Ata>Gta	p.I543V		NM_007218.3	NP_009149.2	Q8WU17	RN139_HUMAN	ring finger protein 139	543					negative regulation of cell proliferation|regulation of protein ubiquitination	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|liver(1)|lung(4)|prostate(1)|skin(1)	20	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			CTTACAAGAAATAAATGATGT	0.378000													31	56					0	0	0.134883	0	0
SDAD1	55153	broad.mit.edu	37	4	76881302	76881302	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr4:76881302T>C	ENST00000356260.5	-	17	1518	c.1400A>G	c.(1399-1401)tAt>tGt	p.Y467C	SDAD1_ENST00000395711.4_Missense_Mutation_p.Y430C|SDAD1_ENST00000513089.1_5'UTR	NM_018115.2	NP_060585.2	Q9NVU7	SDA1_HUMAN	SDA1 domain containing 1	467					protein transport|ribosomal large subunit biogenesis	nucleolus	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	19			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TAATTCTCCATATTCTTGTAC	0.348000													6	67					0	0	0.021553	0	0
OGDHL	55753	broad.mit.edu	37	10	50952733	50952733	+	Missense_Mutation	SNP	A	A	C			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr10:50952733A>C	ENST00000374103.4	-	13	1780	c.1695T>G	c.(1693-1695)atT>atG	p.I565M	OGDHL_ENST00000432695.1_Missense_Mutation_p.I356M|OGDHL_ENST00000419399.1_Missense_Mutation_p.I508M	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	565					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						TTATATGCAGAATCTTTTTAT	0.527000													5	109					0	0	0.021553	0	0
AC024560.3	0	broad.mit.edu	37	3	197348674	197348674	+	RNA	SNP	A	A	G	rs144273946	by1000genomes	TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr3:197348674A>G	ENST00000418868.1	-	0	585					NR_003266.2																						GGCTCTGTCCACCAAATGCAC	0.478000													3	95					0	0	0.115264	0	0
NCAM2	4685	broad.mit.edu	37	21	22804492	22804492	+	Silent	SNP	C	C	A			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr21:22804492C>A	ENST00000400546.1	+	12	1794	c.1545C>A	c.(1543-1545)tcC>tcA	p.S515S	NCAM2_ENST00000284894.7_Silent_p.S373S	NM_004540.3	NP_004531.2	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2	515	Fibronectin type-III 1.				neuron cell-cell adhesion	integral to membrane|plasma membrane				breast(4)|cervix(2)|endometrium(8)|kidney(6)|large_intestine(22)|liver(4)|lung(49)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	108		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		CCAAGGTTTCCTTCAACAAAC	0.453000													7	79					1.12685e-05	1.32003e-05	0.047766	1	0
TCN2	6948	broad.mit.edu	37	22	31008997	31008997	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr22:31008997A>G	ENST00000215838.3	+	3	889	c.395A>G	c.(394-396)aAa>aGa	p.K132R	TCN2_ENST00000405742.3_Missense_Mutation_p.K128R|TCN2_ENST00000407817.3_Intron			P20062	TCO2_HUMAN	transcobalamin II	132					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular space	cobalamin binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|prostate(2)|urinary_tract(1)	22					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TCACAGCTCAAATGGTTCCTG	0.582000													35	31					0	0	0.050027	0	0
TRAF4	9618	broad.mit.edu	37	17	27074944	27074944	+	Missense_Mutation	SNP	T	T	A			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr17:27074944T>A	ENST00000262395.5	+	3	408	c.279T>A	c.(277-279)agT>agA	p.S93R	TRAF4_ENST00000262396.6_Missense_Mutation_p.S93R|TRAF4_ENST00000444415.3_Missense_Mutation_p.S93R	NM_004295.3	NP_004286.2	Q9BUZ4	TRAF4_HUMAN	TNF receptor-associated factor 4	93					apoptosis|positive regulation of JNK cascade|positive regulation of protein homodimerization activity|positive regulation of protein kinase activity|regulation of apoptosis|signal transduction	cytoskeleton|nucleus|perinuclear region of cytoplasm|tight junction	DNA binding|ubiquitin-protein ligase activity|WW domain binding|zinc ion binding			endometrium(2)|large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	10	Lung NSC(42;0.01)		Epithelial(11;3.26e-05)|all cancers(11;0.000272)|OV - Ovarian serous cystadenocarcinoma(11;0.235)			GCCGCTGGAGTGGGCCACTAC	0.612000													25	28					0	0	0.091800	0	0
COL27A1	85301	broad.mit.edu	37	9	117071596	117071596	+	Silent	SNP	G	G	A			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr9:117071596G>A	ENST00000356083.3	+	60	5665	c.5274G>A	c.(5272-5274)gaG>gaA	p.E1758E		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	1758	Fibrillar collagen NC1.				cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						TAAGCTCCGAGGTGACCCAGC	0.617000													109	166					0	0	0.139131	0	0
PPP3R2	5535	broad.mit.edu	37	9	104357184	104357184	+	Missense_Mutation	SNP	T	T	A			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr9:104357184T>A	ENST00000374806.1	-	1	99	c.29A>T	c.(28-30)tAc>tTc	p.Y10F	GRIN3A_ENST00000361820.3_Intron	NM_147180.2	NP_671709.1	Q96LZ3	CANB2_HUMAN	protein phosphatase 3, regulatory subunit B, beta	7							calcium ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	22		Acute lymphoblastic leukemia(62;0.0527)			Cyclosporine(DB00091)	CTCCGCCGGGTAACTGGCCTC	0.587000													42	68					0	0	0.104719	0	0
TIGD4	201798	broad.mit.edu	37	4	153691793	153691793	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr4:153691793C>T	ENST00000304337.2	-	2	1184	c.364G>A	c.(364-366)Ggc>Agc	p.G122S		NM_145720.3	NP_663772.1	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	122	HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			breast(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.093)					TCATTATGGCCCAGTTTCTGG	0.403000													4	150					0	0	0.009096	0	0
EPHB6	0	broad.mit.edu	37	7	142563827	142563827	+	Silent	SNP	C	C	T			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr7:142563827C>T	ENST00000392957.2	+	9	2002	c.1215C>T	c.(1213-1215)gtC>gtT	p.V405V	EPHB6_ENST00000411471.2_Silent_p.V128V|EPHB6_ENST00000442129.1_Silent_p.V405V	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	405	Fibronectin type-III 1.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					TCTTCAATGTCGTGTGCAAGG	0.637000													13	15					0	0	0.093190	0	0
TRIOBP	11078	broad.mit.edu	37	22	38119859	38119859	+	Silent	SNP	C	C	T	rs66505048		TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr22:38119859C>T	ENST00000406386.3	+	7	1551	c.1296C>T	c.(1294-1296)tgC>tgT	p.C432C	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	432					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding	p.C432C(6)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					GAACATCCTGCGCCCAGCGGG	0.582000													4	130					0	0	0.014758	0	0
AGA	175	broad.mit.edu	37	4	178359917	178359917	+	Silent	SNP	G	G	A			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr4:178359917G>A	ENST00000264595.2	-	4	616	c.489C>T	c.(487-489)tgC>tgT	p.C163C	AGA_ENST00000506853.1_5'UTR	NM_000027.3|NM_001171988.1	NP_000018.2|NP_001165459.1	P20933	ASPG_HUMAN	aspartylglucosaminidase	163			C -> S (in AGU; Finnish. Most frequent mutation; >98% of Finnish AGU alleles).		asparagine catabolic process via L-aspartate|protein deglycosylation|protein maturation	endoplasmic reticulum|intermediate filament cytoskeleton|lysosome|microtubule cytoskeleton	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity			endometrium(1)|kidney(2)|large_intestine(6)|lung(5)|skin(2)	16		all_lung(41;1.27e-09)|Lung NSC(41;1.1e-08)|Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Hepatocellular(41;0.148)|all_neural(102;0.164)|Colorectal(36;0.245)		all cancers(43;1.37e-22)|Epithelial(43;3.86e-20)|OV - Ovarian serous cystadenocarcinoma(60;3.8e-11)|Colorectal(24;6.98e-05)|GBM - Glioblastoma multiforme(59;0.000362)|COAD - Colon adenocarcinoma(29;0.000462)|STAD - Stomach adenocarcinoma(60;0.0029)|LUSC - Lung squamous cell carcinoma(193;0.0328)|READ - Rectum adenocarcinoma(43;0.163)		AATTTGGCTGGCAATTCCGAG	0.393000													3	31					0	0	0.115264	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				35	53					0	0	0.092188	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr19:58385546G>T	ENST00000435989.2	-	3	1446	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000600634.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.D404E(10)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						AATGTTTTTTGTCAGTGTGAA	0.393000													3	11					0.115264	0.124364	0.115264	1	0
C16orf72	29035	broad.mit.edu	37	16	9197107	9197107	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr16:9197107G>A	ENST00000327827.7	+	3	971	c.574G>A	c.(574-576)Gct>Act	p.A192T		NM_014117.2	NP_054836.2	Q14CZ0	CP072_HUMAN	chromosome 16 open reading frame 72	192										endometrium(4)|large_intestine(2)|lung(2)	8						GGAAGCCATAGCTCTGCATGG	0.463000													5	53					0	0	0.021553	0	0
SEC22B	9554	broad.mit.edu	37	1	145109312	145109313	+	RNA	INS	-	-	A	rs148903206		TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr1:145109312_145109313insA	ENST00000453618.1	+	0	512							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										aaaccaaaaacaaaAAAAAAAG	0.416													4	6	---	---	---	---					
KIAA1217	56243	broad.mit.edu	37	10	24822125	24822127	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr10:24822125_24822127delGAA	ENST00000376451.2	+	11	2682_2684	c.2422_2424delGAA	c.(2422-2424)del	p.E812del	KIAA1217_ENST00000376454.3_In_Frame_Del_p.E1129del|KIAA1217_ENST00000458595.1_In_Frame_Del_p.E1094del|KIAA1217_ENST00000376452.3_In_Frame_Del_p.E1093del|KIAA1217_ENST00000307544.6_In_Frame_Del_p.E812del|KIAA1217_ENST00000376462.1_In_Frame_Del_p.E1049del|KIAA1217_ENST00000396446.1_In_Frame_Del_p.E812del|KIAA1217_ENST00000396445.1_In_Frame_Del_p.E812del			Q5T5P2	SKT_HUMAN	KIAA1217	1129					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						GGATGAGGAGGAAGAAGAAGAAG	0.552													7	100	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74378976	74378976	+	RNA	DEL	T	T	-	rs35591542		TCGA-DJ-A13U-01A-11D-A10S-08	TCGA-DJ-A13U-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fa6f592-79f4-4ab1-88d3-ad6de13a2802	3e5c2d94-bbd8-42ba-ad64-36af735be8ef	g.chr16:74378976delT	ENST00000429810.2	-	0	1086																											ACCTCTTGAAttttttttttt	0.418													3	4	---	---	---	---