Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
N4BP3	23138	broad.mit.edu	37	5	177547253	177547253	+	Silent	SNP	G	G	A			TCGA-CE-A483-01A-11D-A23U-08	TCGA-CE-A483-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cc9603f-fb8b-4a6c-b048-f6bd6956eb0f	22aacc1b-445f-4882-909b-cccc9f1f90cb	g.chr5:177547253G>A	ENST00000274605.5	+	3	764	c.405G>A	c.(403-405)gcG>gcA	p.A135A		NM_015111.1	NP_055926.1	O15049	N4BP3_HUMAN	NEDD4 binding protein 3	135						cytoplasmic vesicle membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(1)|skin(1)	9	all_cancers(89;0.00294)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AAAGTCTGGCGTCCCACAAAG	0.682000													3	34					0	0	1	0	0
TSSC2	0	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-CE-A483-01A-11D-A23U-08	TCGA-CE-A483-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cc9603f-fb8b-4a6c-b048-f6bd6956eb0f	22aacc1b-445f-4882-909b-cccc9f1f90cb	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													4	48					0	0	1	0	0
SEMA4G	57715	broad.mit.edu	37	10	102743721	102743721	+	Silent	SNP	C	C	T			TCGA-CE-A483-01A-11D-A23U-08	TCGA-CE-A483-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cc9603f-fb8b-4a6c-b048-f6bd6956eb0f	22aacc1b-445f-4882-909b-cccc9f1f90cb	g.chr10:102743721C>T	ENST00000210633.3	+	14	2443	c.2365C>T	c.(2365-2367)Ctg>Ttg	p.L789L	RP11-108L7.4_ENST00000447344.1_RNA|MRPL43_ENST00000370241.3_Intron|MRPL43_ENST00000342071.1_Silent_p.Q192Q|MRPL43_ENST00000370242.4_Silent_p.Q192Q|SEMA4G_ENST00000517724.1_Intron|MRPL43_ENST00000318325.2_Intron|SEMA4G_ENST00000370250.4_Silent_p.L784L|MRPL43_ENST00000299179.5_Intron			Q9NTN9	SEM4G_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G	784					cell differentiation|nervous system development	integral to membrane	receptor activity			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		Colorectal(252;0.234)		Epithelial(162;3.71e-09)|all cancers(201;2.1e-07)		CTTGGTGGCACTGCCCAGCCG	0.652000													4	51					0	0	1	0	0
GLI3	2737	broad.mit.edu	37	7	42005532	42005532	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CE-A483-01A-11D-A23U-08	TCGA-CE-A483-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cc9603f-fb8b-4a6c-b048-f6bd6956eb0f	22aacc1b-445f-4882-909b-cccc9f1f90cb	g.chr7:42005532G>A	ENST00000395925.3	-	15	3223	c.3139C>T	c.(3139-3141)Cag>Tag	p.Q1047*	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	1047					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						GTGTAATTCTGAAGCACGAGA	0.672000									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				17	41					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12343170	12343170	+	Missense_Mutation	SNP	C	C	G			TCGA-CE-A483-01A-11D-A23U-08	TCGA-CE-A483-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cc9603f-fb8b-4a6c-b048-f6bd6956eb0f	22aacc1b-445f-4882-909b-cccc9f1f90cb	g.chr1:12343170C>G	ENST00000358136.3	+	21	5141	c.5011C>G	c.(5011-5013)Ctg>Gtg	p.L1671V	VPS13D_ENST00000356315.4_Missense_Mutation_p.L1671V	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	1671					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CCTGCATTCTCTGCTGATGGA	0.443000													4	85					0	0	1	0	0
FANCD2	2177	broad.mit.edu	37	3	10081545	10081545	+	Silent	SNP	G	G	C	rs17032283	by1000genomes	TCGA-CE-A483-01A-11D-A23U-08	TCGA-CE-A483-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cc9603f-fb8b-4a6c-b048-f6bd6956eb0f	22aacc1b-445f-4882-909b-cccc9f1f90cb	g.chr3:10081545G>C	ENST00000431693.1	+	8	749	c.711G>C	c.(709-711)ctG>ctC	p.L237L	FANCD2_ENST00000287647.3_Intron|FANCD2_ENST00000383807.1_Intron|FANCD2_ENST00000438741.1_Intron|FANCD2_ENST00000419585.1_Intron|FANCD2_ENST00000383806.1_Intron			Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	0	Interaction with FANCE.				DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TAAACCCTCTGTCATCATCTA	0.478000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				4	40					0	0	1	0	0
MTHFD1	4522	broad.mit.edu	37	14	64855041	64855041	+	Missense_Mutation	SNP	T	T	C	rs1076991	by1000genomes	TCGA-CE-A483-01A-11D-A23U-08	TCGA-CE-A483-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cc9603f-fb8b-4a6c-b048-f6bd6956eb0f	22aacc1b-445f-4882-909b-cccc9f1f90cb	g.chr14:64855041T>C	ENST00000545908.1	+	1	293	c.64T>C	c.(64-66)Tgg>Cgg	p.W22R	MTHFD1_ENST00000555709.1_5'UTR|MTHFD1_ENST00000555252.1_5'UTR|MTHFD1_ENST00000216605.7_Missense_Mutation_p.W22R			P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	0	Methylenetetrahydrofolate dehydrogenase and cyclohydrolase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase|methylenetetrahydrofolate dehydrogenase (NADP+) activity|protein binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	30				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	TGTGATCCCCTGGCCAGTCCC	0.622000													3	36					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414373	20414373	+	Silent	SNP	G	G	A			TCGA-CE-A483-01A-11D-A23U-08	TCGA-CE-A483-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cc9603f-fb8b-4a6c-b048-f6bd6956eb0f	22aacc1b-445f-4882-909b-cccc9f1f90cb	g.chr9:20414373G>A	ENST00000380338.4	-	5	757	c.471C>T	c.(469-471)agC>agT	p.S157S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S154S|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	157	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S157S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.527000			T	MLL	ALL								4	53					0	0	1	0	0
CYP2D7P1	0	broad.mit.edu	37	22	42537196	42537196	+	RNA	SNP	T	T	C	rs56404506	by1000genomes	TCGA-CE-A483-01A-11D-A23U-08	TCGA-CE-A483-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cc9603f-fb8b-4a6c-b048-f6bd6956eb0f	22aacc1b-445f-4882-909b-cccc9f1f90cb	g.chr22:42537196T>C	ENST00000435101.1	-	0	261				CYP2D7P1_ENST00000358097.4_RNA|CYP2D7P1_ENST00000433992.1_RNA																endometrium(1)	1						TTCGATGTCATGGGATGTCAT	0.602000													4	12					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109795934	109795934	+	Missense_Mutation	SNP	C	C	T			TCGA-CE-A483-01A-11D-A23U-08	TCGA-CE-A483-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cc9603f-fb8b-4a6c-b048-f6bd6956eb0f	22aacc1b-445f-4882-909b-cccc9f1f90cb	g.chr1:109795934C>T	ENST00000271332.3	+	1	3294	c.3233C>T	c.(3232-3234)tCc>tTc	p.S1078F		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	1078	Cadherin 9.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CTCAATGCCTCCACGGGTGAG	0.587000													4	44					0	0	1	0	0
AJ271736.10	0	broad.mit.edu	37	X	155252868	155252868	+	RNA	SNP	T	T	A			TCGA-CE-A483-01A-11D-A23U-08	TCGA-CE-A483-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cc9603f-fb8b-4a6c-b048-f6bd6956eb0f	22aacc1b-445f-4882-909b-cccc9f1f90cb	g.chrX:155252868T>A	ENST00000285718.7	+	0	819				WASH6P_ENST00000461007.1_RNA														p.P304P(5)									TAGCCGAGCCTCTCAAGGCAG	0.632000													3	10					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593000	96593000	+	Missense_Mutation	SNP	A	A	G	rs111976783		TCGA-CE-A483-01A-11D-A23U-08	TCGA-CE-A483-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cc9603f-fb8b-4a6c-b048-f6bd6956eb0f	22aacc1b-445f-4882-909b-cccc9f1f90cb	g.chr2:96593000A>G	ENST00000456556.1	-	28	1985	c.1901T>C	c.(1900-1902)aTa>aCa	p.I634T						ankyrin repeat domain 36C									p.I634T(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TTCTGTGGCTATATTTGAAAC	0.338000													3	22					0	0	1	0	0
KRT16	3868	broad.mit.edu	37	17	39768695	39768695	+	Silent	SNP	G	G	A	rs138306349	byFrequency	TCGA-CE-A483-01A-11D-A23U-08	TCGA-CE-A483-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cc9603f-fb8b-4a6c-b048-f6bd6956eb0f	22aacc1b-445f-4882-909b-cccc9f1f90cb	g.chr17:39768695G>A	ENST00000301653.4	-	1	310	c.246C>T	c.(244-246)ttC>ttT	p.F82F		NM_005557.3	NP_005548.2	P08779	K1C16_HUMAN	keratin 16	82	Head.				cell proliferation|epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		Breast(137;0.000307)				atcctcccccgaagccactac	0.642000													3	28					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-CE-A483-01A-11D-A23U-08	TCGA-CE-A483-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cc9603f-fb8b-4a6c-b048-f6bd6956eb0f	22aacc1b-445f-4882-909b-cccc9f1f90cb	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				15	20					0	0	1	0	0
GTF2IRD2P1	0	broad.mit.edu	37	7	72658179	72658179	+	RNA	SNP	T	T	C	rs147293416	by1000genomes	TCGA-CE-A483-01A-11D-A23U-08	TCGA-CE-A483-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cc9603f-fb8b-4a6c-b048-f6bd6956eb0f	22aacc1b-445f-4882-909b-cccc9f1f90cb	g.chr7:72658179T>C	ENST00000425256.1	-	0	1732					NR_002164.1																						cagagtgatttcggatgaatt	0.507000													4	46					0	0	1	0	0
TBP	6908	broad.mit.edu	37	6	170871038	170871040	+	In_Frame_Del	DEL	CAA	CAA	-	rs10592950		TCGA-CE-A483-01A-11D-A23U-08	TCGA-CE-A483-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cc9603f-fb8b-4a6c-b048-f6bd6956eb0f	22aacc1b-445f-4882-909b-cccc9f1f90cb	g.chr6:170871038_170871040delCAA	ENST00000392092.2	+	3	493_495	c.214_216delCAA	c.(214-216)del	p.Q95del	TBP_ENST00000540980.1_In_Frame_Del_p.Q75del|TBP_ENST00000230354.6_In_Frame_Del_p.Q95del	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	95	Poly-Gln.		Missing.		cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q72del(3)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		gcagcagcagcaacagcaacagc	0.567													10	53	---	---	---	---					
LURAP1L	286343	broad.mit.edu	37	9	12775861	12775862	+	In_Frame_Ins	INS	-	-	GGCGGCGGC	rs3833707	by1000genomes	TCGA-CE-A483-01A-11D-A23U-08	TCGA-CE-A483-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cc9603f-fb8b-4a6c-b048-f6bd6956eb0f	22aacc1b-445f-4882-909b-cccc9f1f90cb	g.chr9:12775861_12775862insGGCGGCGGC	ENST00000319264.3	+	1	842_843	c.147_148insGGCGGCGGC	c.(145-150)gggcgg>ggGGCGGCGGCgcgg	p.49_50GR>GAAAR	LURAP1L_ENST00000489107.1_3'UTR|RP11-3L8.3_ENST00000417638.1_RNA	NM_203403.1	NP_981948.1	Q8IV03	CI150_HUMAN	leucine rich adaptor protein 1-like	49	Gly-rich.		Missing.					p.G49_G50insGGG(2)|p.G50_G52delGGG(1)									gcggtggtggtggcggcggcgg	0.688													5	9	---	---	---	---					
LTB4R	1241	broad.mit.edu	37	14	24785841	24785841	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CE-A483-01A-11D-A23U-08	TCGA-CE-A483-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cc9603f-fb8b-4a6c-b048-f6bd6956eb0f	22aacc1b-445f-4882-909b-cccc9f1f90cb	g.chr14:24785841delC	ENST00000396789.4	+	2	2709	c.984delC	c.(982-984)ggfs	p.G328fs	LTB4R_ENST00000396782.2_Frame_Shift_Del_p.G328fs|LTB4R_ENST00000345363.3_Frame_Shift_Del_p.G328fs	NM_181657.3	NP_858043.1	Q15722	LT4R1_HUMAN	leukotriene B4 receptor	328					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular component movement|immune response|inflammatory response|muscle contraction	integral to plasma membrane	nucleotide binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|stomach(1)	8				GBM - Glioblastoma multiforme(265;0.018)		CTAGGAGCGGCCCCGCCGCTC	0.706													2	4	---	---	---	---					
GZF1	64412	broad.mit.edu	37	20	23345921	23345923	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-CE-A483-01A-11D-A23U-08	TCGA-CE-A483-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cc9603f-fb8b-4a6c-b048-f6bd6956eb0f	22aacc1b-445f-4882-909b-cccc9f1f90cb	g.chr20:23345921_23345923delGAG	ENST00000338121.5	+	2	978_980	c.901_903delGAG	c.(901-903)del	p.E306del	GZF1_ENST00000377051.2_In_Frame_Del_p.E306del|GZF1_ENST00000542987.1_Intron|GZF1_ENST00000544236.1_Intron|GZF1_ENST00000461789.1_3'UTR			Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	306					transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|urinary_tract(2)	24	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					ggaggaggaagaggaggaggagg	0.532													7	66	---	---	---	---					
IGLL1	3543	broad.mit.edu	37	22	23922291	23922293	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-CE-A483-01A-11D-A23U-08	TCGA-CE-A483-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cc9603f-fb8b-4a6c-b048-f6bd6956eb0f	22aacc1b-445f-4882-909b-cccc9f1f90cb	g.chr22:23922291_23922293delCAG	ENST00000330377.2	-	1	202_204	c.85_87delCTG	c.(85-87)del	p.L29del	IGLL1_ENST00000249053.3_In_Frame_Del_p.L29del	NM_020070.3	NP_064455.1	P15814	IGLL1_HUMAN	immunoglobulin lambda-like polypeptide 1	29					immune response	extracellular region|membrane				kidney(1)|large_intestine(1)|lung(5)|skin(4)|stomach(1)	12						CGGCCAGACCCAGCAGCAGCAGG	0.719													2	4	---	---	---	---