Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CHRNA2	0	broad.mit.edu	37	8	27324815	27324815	+	Missense_Mutation	SNP	A	A	G			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	07a372e2-5e4e-4451-94ac-86db0153a21f	g.chr8:27324815A>G	ENST00000407991.1	-	5	988	c.380T>C	c.(379-381)tTt>tCt	p.F127S	CHRNA2_ENST00000520933.2_Missense_Mutation_p.F127S|CHRNA2_ENST00000240132.2_Missense_Mutation_p.F112S	NM_000742.3	NP_000733.2	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha 2 (neuronal)	127						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine Iodide(DB00416)|Metocurine(DB01336)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	GATGTTGCCAAAATCAGTGGG	0.542000													3	29					0	0	1	0	0
CDH4	1002	broad.mit.edu	37	20	60511927	60511927	+	Missense_Mutation	SNP	T	T	C			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	07a372e2-5e4e-4451-94ac-86db0153a21f	g.chr20:60511927T>C	ENST00000360469.5	+	16	2765	c.2677T>C	c.(2677-2679)Tac>Cac	p.Y893H	CDH4_ENST00000543233.1_Missense_Mutation_p.Y819H	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	893					adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GGACCAAGACTACGATTACCT	0.587000													3	26					0	0	1	0	0
MAML1	9794	broad.mit.edu	37	5	179192842	179192842	+	Silent	SNP	G	G	A			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	07a372e2-5e4e-4451-94ac-86db0153a21f	g.chr5:179192842G>A	ENST00000292599.3	+	2	1094	c.831G>A	c.(829-831)gaG>gaA	p.E277E	MAML1_ENST00000503050.1_3'UTR	NM_014757.4	NP_055572.1	Q92585	MAML1_HUMAN	mastermind-like 1 (Drosophila)	277					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	36	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACTTCGAGGAGAAGAAGGACC	0.507000													5	60					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57553666	57553666	+	Silent	SNP	G	G	A			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	07a372e2-5e4e-4451-94ac-86db0153a21f	g.chr12:57553666G>A	ENST00000243077.3	+	12	2323	c.1857G>A	c.(1855-1857)acG>acA	p.T619T		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	619					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGTACTGGACGGACGATGGGC	0.552000													4	57					0	0	1	0	0
PDE8A	5151	broad.mit.edu	37	15	85669491	85669491	+	Silent	SNP	C	C	T			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	07a372e2-5e4e-4451-94ac-86db0153a21f	g.chr15:85669491C>T	ENST00000310298.4	+	21	2391	c.2139C>T	c.(2137-2139)aaC>aaT	p.N713N	PDE8A_ENST00000557957.1_Silent_p.N641N|PDE8A_ENST00000394553.1_Silent_p.N713N|PDE8A_ENST00000339708.5_Silent_p.N667N			O60658	PDE8A_HUMAN	phosphodiesterase 8A	713	Catalytic (By similarity).				cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	25	Colorectal(223;0.227)		BRCA - Breast invasive adenocarcinoma(143;0.0608)			CTCCAGAGAACCGGACCCTAA	0.463000													3	49					0	0	1	0	0
PRMT10	90826	broad.mit.edu	37	4	148579090	148579090	+	Missense_Mutation	SNP	T	T	A			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	07a372e2-5e4e-4451-94ac-86db0153a21f	g.chr4:148579090T>A	ENST00000322396.6	-	8	1425	c.1183A>T	c.(1183-1185)Att>Ttt	p.I395F	PRMT10_ENST00000541232.1_Missense_Mutation_p.I282F|TMEM184C_ENST00000508208.1_Intron	NM_138364.2	NP_612373.2	Q6P2P2	ANM10_HUMAN	protein arginine methyltransferase 10 (putative)	395						cytoplasm	binding|protein methyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28						GGAATACCAATCTTATCAGGC	0.333000													3	19					0	0	1	0	0
C11orf58	10944	broad.mit.edu	37	11	16760369	16760369	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	07a372e2-5e4e-4451-94ac-86db0153a21f	g.chr11:16760369C>T	ENST00000228136.4	+	1	422	c.44C>T	c.(43-45)tCa>tTa	p.S15L	C11orf58_ENST00000527893.1_Intron|C11orf58_ENST00000422258.2_5'UTR|C11orf58_ENST00000525684.1_Missense_Mutation_p.S15L			O00193	SMAP_HUMAN	chromosome 11 open reading frame 58	15										NS(1)|endometrium(1)|lung(3)|prostate(1)|skin(1)	7						GTGAAGCGTTCAGCCTCCCCA	0.597000													3	35					0	0	1	0	0
LRRC8B	23507	broad.mit.edu	37	1	90049454	90049454	+	Silent	SNP	G	G	A			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	07a372e2-5e4e-4451-94ac-86db0153a21f	g.chr1:90049454G>A	ENST00000330947.2	+	5	1605	c.1245G>A	c.(1243-1245)gtG>gtA	p.V415V	RP5-1007M22.2_ENST00000443562.1_RNA|LRRC8B_ENST00000439853.1_Silent_p.V415V|LRRC8B_ENST00000358200.4_Silent_p.V415V	NM_001134476.1	NP_001127948.1	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member B	415						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	26		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		GTAAGCTTGTGAAAAATGCCC	0.403000													4	54					0	0	1	0	0
SUFU	51684	broad.mit.edu	37	10	104309838	104309838	+	Silent	SNP	C	C	T			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	07a372e2-5e4e-4451-94ac-86db0153a21f	g.chr10:104309838C>T	ENST00000369902.3	+	3	595	c.429C>T	c.(427-429)ggC>ggT	p.G143G	SUFU_ENST00000369899.2_Silent_p.G143G|SUFU_ENST00000423559.2_Silent_p.G143G	NM_016169.3	NP_057253.2	Q9UMX1	SUFU_HUMAN	suppressor of fused homolog (Drosophila)	143					negative regulation of transcription from RNA polymerase II promoter|proteolysis|skeletal system development	cytoplasm|nucleus	identical protein binding|protein binding|signal transducer activity|transcription corepressor activity|transcription factor binding			breast(2)|central_nervous_system(7)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(2)	24		Colorectal(252;0.207)		Epithelial(162;1.36e-08)|all cancers(201;3.81e-07)|BRCA - Breast invasive adenocarcinoma(275;0.242)		TAATGCAGGGCTTGGCACGAT	0.537000			"""D, F, S"""		medulloblastoma	medulloblastoma			Medulloblastoma, associated with Germline SUFU Mutation				4	41					0	0	1	0	0
LRGUK	136332	broad.mit.edu	37	7	133868563	133868563	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	07a372e2-5e4e-4451-94ac-86db0153a21f	g.chr7:133868563C>T	ENST00000285928.2	+	11	1361	c.1292C>T	c.(1291-1293)gCc>gTc	p.A431V		NM_144648.1	NP_653249.1	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain containing	431	Guanylate kinase-like.						ATP binding|kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(23)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	49						CGAGAGCTTGCCCATCGCCTC	0.468000													6	103					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114163300	114163300	+	Silent	SNP	A	A	C			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	07a372e2-5e4e-4451-94ac-86db0153a21f	g.chr4:114163300A>C	ENST00000357077.4	+	9	879	c.826A>C	c.(826-828)Aga>Cga	p.R276R	ANK2_ENST00000264366.6_Silent_p.R276R|ANK2_ENST00000394537.3_Silent_p.R276R|ANK2_ENST00000506722.1_Silent_p.R255R	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	276					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GGCTTCCAAAAGAGGAAATAC	0.453000													14	31					0	0	1	0	0
CDRT4	284040	broad.mit.edu	37	17	15341130	15341130	+	Missense_Mutation	SNP	C	C	T	rs139647100		TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	07a372e2-5e4e-4451-94ac-86db0153a21f	g.chr17:15341130C>T	ENST00000312177.6	-	4	696	c.416G>A	c.(415-417)cGc>cAc	p.R139H	TVP23C-CDRT4_ENST00000522212.2_3'UTR|CDRT4_ENST00000519354.1_5'UTR	NM_001204477.1	NP_001191406.1	Q8N9R6	CDRT4_HUMAN	CMT1A duplicated region transcript 4	139										endometrium(3)|skin(1)	4				UCEC - Uterine corpus endometrioid carcinoma (92;0.0874)		CATAGGCTTGCGGGCAAAGAT	0.488000													3	31					0	0	1	0	0
AKAP8	10270	broad.mit.edu	37	19	15484823	15484823	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	07a372e2-5e4e-4451-94ac-86db0153a21f	g.chr19:15484823C>T	ENST00000269701.2	-	4	205	c.145G>A	c.(145-147)Gca>Aca	p.A49T		NM_005858.3	NP_005849.1	O43823	AKAP8_HUMAN	A kinase (PRKA) anchor protein 8	49					signal transduction	nuclear matrix				breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)	26						CTGTAGGTTGCGCCTGTGGTG	0.632000													3	48					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	07a372e2-5e4e-4451-94ac-86db0153a21f	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				7	36					0	0	1	0	0
CHRNA2	0	broad.mit.edu	37	8	27324815	27324815	+	Missense_Mutation	SNP	A	A	G			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	f7390ccb-39a9-4ca0-9666-40768e1512ec	g.chr8:27324815A>G	ENST00000407991.1	-	5	988	c.380T>C	c.(379-381)tTt>tCt	p.F127S	CHRNA2_ENST00000240132.2_Missense_Mutation_p.F112S|CHRNA2_ENST00000520933.2_Missense_Mutation_p.F127S	NM_000742.3	NP_000733.2	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha 2 (neuronal)	127						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine Iodide(DB00416)|Metocurine(DB01336)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	GATGTTGCCAAAATCAGTGGG	0.542000													3	29					0	0	1	0	0
CDH4	1002	broad.mit.edu	37	20	60511927	60511927	+	Missense_Mutation	SNP	T	T	C			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	f7390ccb-39a9-4ca0-9666-40768e1512ec	g.chr20:60511927T>C	ENST00000360469.5	+	16	2765	c.2677T>C	c.(2677-2679)Tac>Cac	p.Y893H	CDH4_ENST00000543233.1_Missense_Mutation_p.Y819H	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	893					adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GGACCAAGACTACGATTACCT	0.587000													3	26					0	0	1	0	0
MAML1	9794	broad.mit.edu	37	5	179192842	179192842	+	Silent	SNP	G	G	A			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	f7390ccb-39a9-4ca0-9666-40768e1512ec	g.chr5:179192842G>A	ENST00000292599.3	+	2	1094	c.831G>A	c.(829-831)gaG>gaA	p.E277E	MAML1_ENST00000503050.1_3'UTR	NM_014757.4	NP_055572.1	Q92585	MAML1_HUMAN	mastermind-like 1 (Drosophila)	277					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	36	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACTTCGAGGAGAAGAAGGACC	0.507000													5	60					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57553666	57553666	+	Silent	SNP	G	G	A			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	f7390ccb-39a9-4ca0-9666-40768e1512ec	g.chr12:57553666G>A	ENST00000243077.3	+	12	2323	c.1857G>A	c.(1855-1857)acG>acA	p.T619T		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	619					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGTACTGGACGGACGATGGGC	0.552000													4	57					0	0	1	0	0
PDE8A	5151	broad.mit.edu	37	15	85669491	85669491	+	Silent	SNP	C	C	T			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	f7390ccb-39a9-4ca0-9666-40768e1512ec	g.chr15:85669491C>T	ENST00000310298.4	+	21	2391	c.2139C>T	c.(2137-2139)aaC>aaT	p.N713N	PDE8A_ENST00000339708.5_Silent_p.N667N|PDE8A_ENST00000394553.1_Silent_p.N713N|PDE8A_ENST00000557957.1_Silent_p.N641N			O60658	PDE8A_HUMAN	phosphodiesterase 8A	713	Catalytic (By similarity).				cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	25	Colorectal(223;0.227)		BRCA - Breast invasive adenocarcinoma(143;0.0608)			CTCCAGAGAACCGGACCCTAA	0.463000													3	49					0	0	1	0	0
PRMT10	90826	broad.mit.edu	37	4	148579090	148579090	+	Missense_Mutation	SNP	T	T	A			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	f7390ccb-39a9-4ca0-9666-40768e1512ec	g.chr4:148579090T>A	ENST00000322396.6	-	8	1425	c.1183A>T	c.(1183-1185)Att>Ttt	p.I395F	PRMT10_ENST00000541232.1_Missense_Mutation_p.I282F|TMEM184C_ENST00000508208.1_Intron	NM_138364.2	NP_612373.2	Q6P2P2	ANM10_HUMAN	protein arginine methyltransferase 10 (putative)	395						cytoplasm	binding|protein methyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28						GGAATACCAATCTTATCAGGC	0.333000													3	19					0	0	1	0	0
C11orf58	10944	broad.mit.edu	37	11	16760369	16760369	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	f7390ccb-39a9-4ca0-9666-40768e1512ec	g.chr11:16760369C>T	ENST00000228136.4	+	1	422	c.44C>T	c.(43-45)tCa>tTa	p.S15L	C11orf58_ENST00000527893.1_Intron|C11orf58_ENST00000422258.2_5'UTR|C11orf58_ENST00000525684.1_Missense_Mutation_p.S15L			O00193	SMAP_HUMAN	chromosome 11 open reading frame 58	15										NS(1)|endometrium(1)|lung(3)|prostate(1)|skin(1)	7						GTGAAGCGTTCAGCCTCCCCA	0.597000													3	35					0	0	1	0	0
SUFU	51684	broad.mit.edu	37	10	104309838	104309838	+	Silent	SNP	C	C	T			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	f7390ccb-39a9-4ca0-9666-40768e1512ec	g.chr10:104309838C>T	ENST00000369902.3	+	3	595	c.429C>T	c.(427-429)ggC>ggT	p.G143G	SUFU_ENST00000423559.2_Silent_p.G143G|SUFU_ENST00000369899.2_Silent_p.G143G	NM_016169.3	NP_057253.2	Q9UMX1	SUFU_HUMAN	suppressor of fused homolog (Drosophila)	143					negative regulation of transcription from RNA polymerase II promoter|proteolysis|skeletal system development	cytoplasm|nucleus	identical protein binding|protein binding|signal transducer activity|transcription corepressor activity|transcription factor binding			breast(2)|central_nervous_system(7)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(2)	24		Colorectal(252;0.207)		Epithelial(162;1.36e-08)|all cancers(201;3.81e-07)|BRCA - Breast invasive adenocarcinoma(275;0.242)		TAATGCAGGGCTTGGCACGAT	0.537000			"""D, F, S"""		medulloblastoma	medulloblastoma			Medulloblastoma, associated with Germline SUFU Mutation				4	41					0	0	1	0	0
LRGUK	136332	broad.mit.edu	37	7	133868563	133868563	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	f7390ccb-39a9-4ca0-9666-40768e1512ec	g.chr7:133868563C>T	ENST00000285928.2	+	11	1361	c.1292C>T	c.(1291-1293)gCc>gTc	p.A431V		NM_144648.1	NP_653249.1	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain containing	431	Guanylate kinase-like.						ATP binding|kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(23)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	49						CGAGAGCTTGCCCATCGCCTC	0.468000													6	103					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114163300	114163300	+	Silent	SNP	A	A	C			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	f7390ccb-39a9-4ca0-9666-40768e1512ec	g.chr4:114163300A>C	ENST00000357077.4	+	9	879	c.826A>C	c.(826-828)Aga>Cga	p.R276R	ANK2_ENST00000394537.3_Silent_p.R276R|ANK2_ENST00000264366.6_Silent_p.R276R|ANK2_ENST00000506722.1_Silent_p.R255R	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	276					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GGCTTCCAAAAGAGGAAATAC	0.453000													14	31					0	0	1	0	0
CDRT4	284040	broad.mit.edu	37	17	15341130	15341130	+	Missense_Mutation	SNP	C	C	T	rs139647100		TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	f7390ccb-39a9-4ca0-9666-40768e1512ec	g.chr17:15341130C>T	ENST00000312177.6	-	4	696	c.416G>A	c.(415-417)cGc>cAc	p.R139H	TVP23C-CDRT4_ENST00000522212.2_3'UTR|CDRT4_ENST00000519354.1_5'UTR	NM_001204477.1	NP_001191406.1	Q8N9R6	CDRT4_HUMAN	CMT1A duplicated region transcript 4	139										endometrium(3)|skin(1)	4				UCEC - Uterine corpus endometrioid carcinoma (92;0.0874)		CATAGGCTTGCGGGCAAAGAT	0.488000													3	31					0	0	1	0	0
AKAP8	10270	broad.mit.edu	37	19	15484823	15484823	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	f7390ccb-39a9-4ca0-9666-40768e1512ec	g.chr19:15484823C>T	ENST00000269701.2	-	4	205	c.145G>A	c.(145-147)Gca>Aca	p.A49T		NM_005858.3	NP_005849.1	O43823	AKAP8_HUMAN	A kinase (PRKA) anchor protein 8	49					signal transduction	nuclear matrix				breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)	26						CTGTAGGTTGCGCCTGTGGTG	0.632000													3	48					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	f7390ccb-39a9-4ca0-9666-40768e1512ec	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				7	36					0	0	1	0	0
LRRC8B	23507	broad.mit.edu	37	1	90049454	90049454	+	Silent	SNP	G	G	A			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	f7390ccb-39a9-4ca0-9666-40768e1512ec	g.chr1:90049454G>A	ENST00000330947.2	+	5	1605	c.1245G>A	c.(1243-1245)gtG>gtA	p.V415V	LRRC8B_ENST00000439853.1_Silent_p.V415V|LRRC8B_ENST00000358200.4_Silent_p.V415V|RP5-1007M22.2_ENST00000443562.1_RNA	NM_001134476.1	NP_001127948.1	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member B	415						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	26		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		GTAAGCTTGTGAAAAATGCCC	0.403000													4	54					0	0	1	0	0
RP11-242J7.1	0	broad.mit.edu	37	4	185536410	185536413	+	RNA	DEL	TTTG	TTTG	-	rs146473442		TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	07a372e2-5e4e-4451-94ac-86db0153a21f	g.chr4:185536410_185536413delTTTG	ENST00000522554.1	-	0	292																											CAAAGCCGATtttgtttgtttgtt	0.451													4	3	---	---	---	---					
ATG9B	285973	broad.mit.edu	37	7	150721483	150721484	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	07a372e2-5e4e-4451-94ac-86db0153a21f	g.chr7:150721483_150721484insC	ENST00000605938.1	-	1	102_103	c.27_28insG	c.(25-30)gggaagfs	p.K10fs	ATG9B_ENST00000377974.2_Frame_Shift_Ins_p.K10fs|ATG9B_ENST00000494791.1_5'UTR|ATG9B_ENST00000444312.1_5'UTR|ATG9B_ENST00000605952.1_Frame_Shift_Ins_p.K10fs	NM_173681.5	NP_775952.4	Q674R7	ATG9B_HUMAN	autophagy related 9B	10					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(4)|prostate(1)	14	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGCCTTCTTCTCCCCCCCCAGC	0.644													2	4	---	---	---	---					
ATG9B	285973	broad.mit.edu	37	7	150721483	150721484	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	f7390ccb-39a9-4ca0-9666-40768e1512ec	g.chr7:150721483_150721484insC	ENST00000605938.1	-	1	102_103	c.27_28insG	c.(25-30)gggaagfs	p.K10fs	ATG9B_ENST00000377974.2_Frame_Shift_Ins_p.K10fs|ATG9B_ENST00000494791.1_5'UTR|ATG9B_ENST00000444312.1_5'UTR|ATG9B_ENST00000605952.1_Frame_Shift_Ins_p.K10fs	NM_173681.5	NP_775952.4	Q674R7	ATG9B_HUMAN	autophagy related 9B	10					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(4)|prostate(1)	14	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGCCTTCTTCTCCCCCCCCAGC	0.644													2	4	---	---	---	---					
TPTE2P1	0	broad.mit.edu	37	13	25527490	25527491	+	RNA	INS	-	-	AAAAAG			TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	f7390ccb-39a9-4ca0-9666-40768e1512ec	g.chr13:25527490_25527491insAAAAAG	ENST00000429698.1	-	0	282																											AGGAAGGTTCTAAAAAAAATTT	0.252													4	8	---	---	---	---					
CTD-2509G16.5	0	broad.mit.edu	37	14	65748002	65748005	+	RNA	DEL	TTTT	TTTT	-	rs1760975		TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	f7390ccb-39a9-4ca0-9666-40768e1512ec	g.chr14:65748002_65748005delTTTT	ENST00000553754.1	-	0	300																											TCTTTCtttctttttttttttttt	0.485													2	4	---	---	---	---					
RP11-439I14.2	0	broad.mit.edu	37	16	64770704	64770705	+	RNA	INS	-	-	CCAGTGATGGTCACCT	rs140029302	by1000genomes	TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	f7390ccb-39a9-4ca0-9666-40768e1512ec	g.chr16:64770704_64770705insCCAGTGATGGTCACCT	ENST00000564293.1	+	0	453_454																											TGTCACCACTGCCACCTTGTTC	0.371													3	3	---	---	---	---					
ROCK1P1	0	broad.mit.edu	37	18	112402	112405	+	RNA	DEL	AACC	AACC	-	rs113232824		TCGA-BJ-A45I-01A-11D-A23U-08	TCGA-BJ-A45I-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5b13884-6885-4ecd-b7a9-21085bca623a	f7390ccb-39a9-4ca0-9666-40768e1512ec	g.chr18:112402_112405delAACC	ENST00000576266.1	+	0	36_39																											CCCTGCCCCGAACCACCCGACCCC	0.711													2	4	---	---	---	---