Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FAM171B	165215	broad.mit.edu	37	2	187559053	187559053	+	Silent	SNP	A	A	G	rs2370706		TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr2:187559053A>G	ENST00000304698.5	+	1	356	c.153A>G	c.(151-153)caA>caG	p.Q51Q	AC017101.10_ENST00000453665.1_RNA	NM_177454.3	NP_803237.3	Q6P995	F171B_HUMAN	family with sequence similarity 171, member B	51	Gln-rich.					integral to membrane	DNA binding			NS(1)|breast(6)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(22)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						agcagcaacaacaacaacaac	0.632000													3	21					0	0	0.004672	0	0
SUPT20H	55578	broad.mit.edu	37	13	37622068	37622068	+	Silent	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr13:37622068G>A	ENST00000360252.4	-	4	292	c.45C>T	c.(43-45)gtC>gtT	p.V15V	SUPT20H_ENST00000356185.3_Silent_p.V15V|SUPT20H_ENST00000464744.1_Silent_p.V15V|SUPT20H_ENST00000470359.2_5'UTR|SUPT20H_ENST00000350612.6_Silent_p.V15V|SUPT20H_ENST00000475892.1_Silent_p.V15V|SUPT20H_ENST00000542180.1_Silent_p.V3V	NM_001278481.1|NM_001278482.1|NM_017569.3	NP_001265410.1|NP_001265411.1|NP_060039.1			suppressor of Ty 20 homolog (S. cerevisiae)																		CACTTTCAATGACATACTAAA	0.318000													6	52					0	0	0.001168	0	0
SLC34A2	10568	broad.mit.edu	37	4	25678361	25678361	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr4:25678361C>T	ENST00000382051.3	+	13	2113	c.2063C>T	c.(2062-2064)aCg>aTg	p.T688M	SLC34A2_ENST00000504570.1_Missense_Mutation_p.T687M|SLC34A2_ENST00000503434.1_Missense_Mutation_p.T687M	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	688					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				ACCGAATGCACGGCCTTGTAG	0.567000			T	ROS1	NSCLC								20	33					0	0	0.008871	0	0
SWSAP1	126074	broad.mit.edu	37	19	11486194	11486194	+	Silent	SNP	C	C	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr19:11486194C>A	ENST00000312423.2	+	2	251	c.192C>A	c.(190-192)atC>atA	p.I64I		NM_175871.3	NP_787067.2	Q6NVH7	CS039_HUMAN	SWIM-type zinc finger 7 associated protein 1	64																	TCTAGAAGATCCGCTTCCAGT	0.587000													80	134					4.64247e-43	5.0359e-43	0.014410	1	0
NKX2-1	7080	broad.mit.edu	37	14	36988488	36988488	+	Missense_Mutation	SNP	C	C	G			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr14:36988488C>G	ENST00000518149.1	-	2	680	c.75G>C	c.(73-75)aaG>aaC	p.K25N	RP11-896J10.3_ENST00000521945.1_RNA|NKX2-1_ENST00000354822.5_Missense_Mutation_p.K55N|NKX2-1_ENST00000522719.2_Missense_Mutation_p.K25N|NKX2-1-AS1_ENST00000521292.2_RNA|NKX2-1_ENST00000498187.2_Missense_Mutation_p.K25N			P43699	NKX21_HUMAN	NK2 homeobox 1	25					epithelial tube branching involved in lung morphogenesis|globus pallidus development|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|thyroid gland development		protein binding|transcription regulatory region DNA binding			large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(2)	7	all_cancers(3;4.47e-51)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.165)		Lung(8;1.8e-08)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.014)|all cancers(34;0.0366)|LUSC - Lung squamous cell carcinoma(13;0.132)	GBM - Glioblastoma multiforme(112;0.0171)		TGCCCACTTTCTTGTAGCTTT	0.652000			A		NSCLC								3	20					0	0	0.009096	0	0
OR2C1	4993	broad.mit.edu	37	16	3405956	3405956	+	Missense_Mutation	SNP	G	G	C			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr16:3405956G>C	ENST00000304936.2	+	1	68	c.16G>C	c.(16-18)Gat>Cat	p.D6H		NM_012368.2	NP_036500.2	O95371	OR2C1_HUMAN	olfactory receptor, family 2, subfamily C, member 1	6					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|liver(1)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						CGGGGTGAATGATAGCTCCTT	0.463000													9	42					0	0	0.006214	0	0
SLC13A5	284111	broad.mit.edu	37	17	6607201	6607201	+	Silent	SNP	C	C	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr17:6607201C>A	ENST00000433363.2	-	4	776	c.543G>T	c.(541-543)ctG>ctT	p.L181L	SLC13A5_ENST00000381074.4_Silent_p.L138L|SLC13A5_ENST00000573648.1_Silent_p.L181L|SLC13A5_ENST00000293800.6_Silent_p.L164L	NM_177550.3	NP_808218.1	Q86YT5	S13A5_HUMAN	solute carrier family 13 (sodium-dependent citrate transporter), member 5	181						integral to membrane	citrate transmembrane transporter activity	p.L181L(3)		breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|prostate(5)|skin(3)|urinary_tract(1)	26						GCTCACCTGGCAGCTCCTTGG	0.642000													5	22					5.9392e-07	6.23129e-07	0.001168	1	0
SPC25	57405	broad.mit.edu	37	2	169732647	169732647	+	Missense_Mutation	SNP	T	T	C			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr2:169732647T>C	ENST00000282074.2	-	5	527	c.386A>G	c.(385-387)aAa>aGa	p.K129R		NM_020675.3	NP_065726.1	Q9HBM1	SPC25_HUMAN	SPC25, NDC80 kinetochore complex component	129	Interaction with the N-terminus of SPBC24.				cell division|chromosome segregation|mitotic prometaphase|mitotic spindle organization	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(3)|urinary_tract(1)	9						CTGCAGCCTTTTCAACCTCTC	0.289000													2	17					0	0	0.004672	0	0
PHF23	79142	broad.mit.edu	37	17	7139847	7139847	+	Silent	SNP	G	G	C			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr17:7139847G>C	ENST00000320316.3	-	4	625	c.399C>G	c.(397-399)ctC>ctG	p.L133L	PHF23_ENST00000576955.1_Silent_p.L3L|PHF23_ENST00000454255.2_Silent_p.L129L|PHF23_ENST00000571362.1_Silent_p.L66L	NM_024297.2	NP_077273.2	Q9BUL5	PHF23_HUMAN	PHD finger protein 23	133							zinc ion binding			breast(4)|kidney(2)|large_intestine(6)|lung(3)	15						GAGAGTCCTTGAGCTTCATCT	0.602000													11	65					0	0	0.010729	0	0
OXER1	165140	broad.mit.edu	37	2	42991172	42991172	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr2:42991172G>A	ENST00000378661.2	-	1	229	c.148C>T	c.(148-150)Ccc>Tcc	p.P50S		NM_148962.4	NP_683765.1	Q8TDS5	OXER1_HUMAN	oxoeicosanoid (OXE) receptor 1	50	Ser-rich.				regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)	10						gagagagagggagatggagag	0.602000													6	39					0	0	0.001984	0	0
IGSF22	283284	broad.mit.edu	37	11	18741432	18741432	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr11:18741432G>A	ENST00000513874.1	-	7	666	c.527C>T	c.(526-528)cCt>cTt	p.P176L	RP11-1081L13.4_ENST00000527285.1_RNA	NM_173588.3	NP_775859.3	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	176	Lys-rich.									NS(2)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(20)|ovary(4)|prostate(4)|skin(3)	56						CTTGGGAGCAGGGGGTGCCCT	0.502000													7	117					0	0	0.001984	0	0
ABHD2	11057	broad.mit.edu	37	15	89659640	89659640	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr15:89659640G>A	ENST00000352732.5	+	3	602	c.82G>A	c.(82-84)Gtg>Atg	p.V28M	ABHD2_ENST00000355100.3_Missense_Mutation_p.V28M|ABHD2_ENST00000565973.1_Missense_Mutation_p.V28M	NM_152924.4	NP_690888.1	P08910	ABHD2_HUMAN	abhydrolase domain containing 2	28						integral to membrane	carboxylesterase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|soft_tissue(1)	23	Lung NSC(78;0.0472)|all_lung(78;0.089)					TGTGCTGTACGTGATCGTCCG	0.577000													34	59					0	0	0.015359	0	0
PHF23	79142	broad.mit.edu	37	17	7139630	7139630	+	Missense_Mutation	SNP	G	G	C			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr17:7139630G>C	ENST00000320316.3	-	4	842	c.616C>G	c.(616-618)Cct>Gct	p.P206A	PHF23_ENST00000576955.1_Missense_Mutation_p.P76A|PHF23_ENST00000454255.2_Missense_Mutation_p.P202A|PHF23_ENST00000571362.1_Missense_Mutation_p.P139A	NM_024297.2	NP_077273.2	Q9BUL5	PHF23_HUMAN	PHD finger protein 23	206							zinc ion binding			breast(4)|kidney(2)|large_intestine(6)|lung(3)	15						CCATCCCCAGGAGTTGGCCGA	0.582000													17	76					0	0	0.004007	0	0
ST8SIA1	6489	broad.mit.edu	37	12	22487068	22487068	+	Silent	SNP	A	A	G			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr12:22487068A>G	ENST00000396037.4	-	1	580	c.99T>C	c.(97-99)agT>agC	p.S33S	ST8SIA1_ENST00000536558.1_Intron|ST8SIA1_ENST00000539510.1_5'UTR|ST8SIA1_ENST00000404299.3_Silent_p.S33S|ST8SIA1_ENST00000381424.3_Silent_p.S33S	NM_003034.3	NP_003025.1	Q92185	SIA8A_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	33					glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	25						CACAGAGGGCACTGGCTCCCA	0.667000													29	72					0	0	0.008361	0	0
MYF5	4617	broad.mit.edu	37	12	81112653	81112653	+	Silent	SNP	T	T	C			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr12:81112653T>C	ENST00000228644.3	+	3	743	c.591T>C	c.(589-591)gaT>gaC	p.D197D		NM_005593.2	NP_005584.2	P13349	MYF5_HUMAN	myogenic factor 5	197					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(8)|lung(15)|ovary(2)|pancreas(1)	30						ATGCCACAGATAAAAACTCCT	0.423000													34	60					0	0	0.021022	0	0
TDGF1P3	0	broad.mit.edu	37	X	109764445	109764445	+	RNA	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chrX:109764445G>A	ENST00000602699.1	+	0	906					NR_002718.2																						ATTAGTTGCCGGGCTGGGCCA	0.522000													11	31					0	0	0.013537	0	0
MDN1	23195	broad.mit.edu	37	6	90400467	90400467	+	Silent	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr6:90400467C>T	ENST00000369393.3	-	64	10789	c.10674G>A	c.(10672-10674)agG>agA	p.R3558R	MDN1_ENST00000428876.1_Silent_p.R3558R			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	3558					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TCCTAGAGTTCCTGCTCCTGT	0.517000													6	42					0	0	0.001984	0	0
TBC1D3	729873	broad.mit.edu	37	17	36352489	36352489	+	Translation_Start_Site	SNP	A	A	C	rs4796259	by1000genomes	TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr17:36352489A>C	ENST00000537432.1	-	0	359				RP11-1407O15.2_ENST00000544906.1_Missense_Mutation_p.F278C|RP11-1407O15.2_ENST00000312412.4_Missense_Mutation_p.F433C			Q8IZP1	TBC3A_HUMAN	TBC1 domain family, member 3							intracellular	Rab GTPase activator activity			breast(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	5	Breast(7;2.97e-12)	Breast(25;0.102)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TATAGCATCAAATATCTCATC	0.388000													6	38					0	0	0.003080	0	0
OXER1	165140	broad.mit.edu	37	2	42991137	42991137	+	Silent	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr2:42991137G>A	ENST00000378661.2	-	1	264	c.183C>T	c.(181-183)ttC>ttT	p.F61F		NM_148962.4	NP_683765.1	Q8TDS5	OXER1_HUMAN	oxoeicosanoid (OXE) receptor 1	61	Ser-rich.				regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)	10						gtgagggagagaaggagggag	0.612000													8	20					0	0	0.003080	0	0
ALOX12B	242	broad.mit.edu	37	17	7977036	7977036	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr17:7977036C>T	ENST00000319144.4	-	13	1954	c.1694G>A	c.(1693-1695)cGa>cAa	p.R565Q	ALOX12B_ENST00000577351.1_Intron	NM_001139.2	NP_001130.1	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	565	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	16						AGTGACATATCGGATCAGCTC	0.622000										Multiple Myeloma(8;0.094)	OREG0024152	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	20					0	0	0.004672	0	0
NFE2L3	9603	broad.mit.edu	37	7	26224243	26224243	+	Missense_Mutation	SNP	A	A	G	rs144296822	byFrequency	TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr7:26224243A>G	ENST00000056233.3	+	4	1184	c.925A>G	c.(925-927)Ata>Gta	p.I309V		NM_004289.6	NP_004280.5	Q9Y4A8	NF2L3_HUMAN	nuclear factor, erythroid 2-like 3	309					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(5)|urinary_tract(7)	29						CAGCCAGGCTATAAGTCAGGA	0.423000													43	70					0	0	0.008740	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S164S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								4	51					0	0	0.014758	0	0
AL031666.2	0	broad.mit.edu	37	20	45947814	45947814	+	Silent	SNP	A	A	G			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr20:45947814A>G	ENST00000599904.1	+	1	569	c.450A>G	c.(448-450)ggA>ggG	p.G150G	ZMYND8_ENST00000355972.4_Intron|ZMYND8_ENST00000458360.2_Intron|ZMYND8_ENST00000540497.1_Intron|ZMYND8_ENST00000352431.2_Intron|ZMYND8_ENST00000471951.2_Intron|ZMYND8_ENST00000360911.3_Intron|ZMYND8_ENST00000311275.7_Intron|ZMYND8_ENST00000372023.3_Intron|ZMYND8_ENST00000536340.1_Intron|ZMYND8_ENST00000262975.4_Intron|ZMYND8_ENST00000461685.1_Intron|ZMYND8_ENST00000446994.2_Intron|ZMYND8_ENST00000396281.4_Intron																							TCCCAGGGGGAGGAGGAAGAA	0.592000													2	7					0	0	0.004672	0	0
TAF7L	54457	broad.mit.edu	37	X	100547854	100547854	+	Translation_Start_Site	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chrX:100547854G>A	ENST00000372905.2	-	0	205				TAF7L_ENST00000372907.3_Silent_p.D60D			Q5H9L4	TAF7L_HUMAN	TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa						cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			NS(1)|breast(4)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						GAGTGTCCTCGTCGGCAGGAA	0.562000													65	27					0	0	0.014410	0	0
FA2H	79152	broad.mit.edu	37	16	74750252	74750252	+	Missense_Mutation	SNP	C	C	G			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr16:74750252C>G	ENST00000219368.3	-	6	1101	c.1032G>C	c.(1030-1032)caG>caC	p.Q344H	FA2H_ENST00000544337.1_Missense_Mutation_p.Q131H	NM_024306.4	NP_077282.3	Q7L5A8	FA2H_HUMAN	fatty acid 2-hydroxylase	344					cell death|electron transport chain|fatty acid biosynthetic process|sphingolipid metabolic process|transport	endoplasmic reticulum membrane|integral to membrane|microsome	heme binding|oxidoreductase activity			endometrium(2)|large_intestine(4)|lung(3)|skin(1)	10						CACCTGACTTCTGATGTGCAA	0.542000													7	42					0	0	0.003080	0	0
KIAA0319L	79932	broad.mit.edu	37	1	35915475	35915475	+	Silent	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr1:35915475C>T	ENST00000325722.3	-	15	2580	c.2346G>A	c.(2344-2346)gtG>gtA	p.V782V	KIAA0319L_ENST00000485551.1_5'UTR|KIAA0319L_ENST00000373266.4_Silent_p.V219V	NM_024874.4	NP_079150.3	Q8IZA0	K319L_HUMAN	KIAA0319-like	782	PKD 5.					cytoplasmic vesicle part|integral to membrane	protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(12)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	34		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CACCAGGTTTCACCTCCACAG	0.493000													11	44					0	0	0.010729	0	0
KHNYN	23351	broad.mit.edu	37	14	24900883	24900883	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr14:24900883C>T	ENST00000251343.5	+	3	555	c.416C>T	c.(415-417)gCa>gTa	p.A139V	KHNYN_ENST00000553935.1_Missense_Mutation_p.A139V|KHNYN_ENST00000556842.1_Missense_Mutation_p.A139V			O15037	KHNYN_HUMAN	KH and NYN domain containing	139										kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(3)|pancreas(1)|prostate(3)	24						GAAGAGCTGGCAGAGCGGCTG	0.622000											OREG0022627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	55					0	0	0.003080	0	0
UNC13A	23025	broad.mit.edu	37	19	17756912	17756912	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr19:17756912C>T	ENST00000428389.2	-	19	2316	c.2317G>A	c.(2317-2319)Gcc>Acc	p.A773T	UNC13A_ENST00000519716.2_Missense_Mutation_p.A685T|UNC13A_ENST00000551649.1_Missense_Mutation_p.A685T|UNC13A_ENST00000550896.1_Missense_Mutation_p.A683T|UNC13A_ENST00000252773.7_Missense_Mutation_p.A685T|UNC13A_ENST00000552293.1_Missense_Mutation_p.A685T			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	685					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding	p.A685T(1)		breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						AAGCCCTGGGCGCAGACCACT	0.557000													5	23					0	0	0.001168	0	0
ATG14	22863	broad.mit.edu	37	14	55848817	55848817	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr14:55848817G>A	ENST00000247178.5	-	6	775	c.740C>T	c.(739-741)tCa>tTa	p.S247L		NM_014924.4	NP_055739.2	Q6ZNE5	BAKOR_HUMAN	autophagy related 14	247					autophagic vacuole assembly|positive regulation of autophagy	autophagic vacuole|endoplasmic reticulum|pre-autophagosomal structure membrane	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(2)	13						CCATCGTCCTGAGAGGTAAGT	0.532000													21	81					0	0	0.014323	0	0
SNX31	169166	broad.mit.edu	37	8	101661544	101661544	+	Silent	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr8:101661544G>A	ENST00000311812.2	-	2	249	c.99C>T	c.(97-99)ttC>ttT	p.F33F		NM_152628.3	NP_689841.3	Q8N9S9	SNX31_HUMAN	sorting nexin 31	33	PX.				cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			GCACCCTGCAGAAGAGGAACC	0.612000													4	34					0	0	0.014758	0	0
TTBK2	146057	broad.mit.edu	37	15	43067809	43067809	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr15:43067809C>T	ENST00000267890.6	-	13	1630	c.1522G>A	c.(1522-1524)Gat>Aat	p.D508N		NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	508					cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		TATTCTTCATCATAGTGCCAG	0.502000													12	80					0	0	0.013537	0	0
CREB3L3	84699	broad.mit.edu	37	19	4154971	4154971	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr19:4154971G>A	ENST00000078445.2	+	2	250	c.103G>A	c.(103-105)Ggc>Agc	p.G35S	CREB3L3_ENST00000595923.1_Missense_Mutation_p.G35S|CREB3L3_ENST00000602147.1_Missense_Mutation_p.G35S|CREB3L3_ENST00000602257.1_Missense_Mutation_p.G35S|CREB3L3_ENST00000252587.3_Missense_Mutation_p.G26S	NM_001271995.1|NM_001271996.1|NM_032607.1	NP_001258924.1|NP_001258925.1|NP_115996.1	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like 3	35					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(2)|urinary_tract(3)	24				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGGCAGGACGGCATCCTGAG	0.637000													26	63					0	0	0.007291	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701879	56701879	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr19:56701879C>T	ENST00000586855.2	-	5	1118	c.805G>A	c.(805-807)Gac>Aac	p.D269N	ZSCAN5B_ENST00000358992.3_Missense_Mutation_p.D269N			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	269					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						GAAGGTGTGTCAGCATCCACA	0.502000													24	111					0	0	0.016522	0	0
TYMP	1890	broad.mit.edu	37	22	50967746	50967746	+	Missense_Mutation	SNP	C	C	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr22:50967746C>A	ENST00000252029.3	-	3	398	c.236G>T	c.(235-237)cGa>cTa	p.R79L	TYMP_ENST00000395681.1_Missense_Mutation_p.R79L|TYMP_ENST00000395678.3_Missense_Mutation_p.R79L|TYMP_ENST00000395680.1_Missense_Mutation_p.R79L	NM_001113755.2|NM_001113756.2|NM_001257988.1|NM_001257989.1|NM_001953.4	NP_001107227.1|NP_001107228.1|NP_001244917.1|NP_001244918.1|NP_001944.1	P19971	TYPH_HUMAN	thymidine phosphorylase	79					angiogenesis|cell differentiation|chemotaxis|DNA replication|mitochondrial genome maintenance|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol	growth factor activity|platelet-derived growth factor receptor binding|pyrimidine-nucleoside phosphorylase activity|thymidine phosphorylase activity			large_intestine(1)|lung(2)|ovary(1)|prostate(1)	5		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)	Capecitabine(DB01101)|Docetaxel(DB01248)|Floxuridine(DB00322)|Fluorouracil(DB00544)|Sulfasalazine(DB00795)|Tamoxifen(DB00675)	GCCCCGAAGTCGGATGGCCAT	0.692000													13	26					1.5842e-08	1.68981e-08	0.016723	1	0
MYO9B	4650	broad.mit.edu	37	19	17313022	17313022	+	Silent	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr19:17313022G>A	ENST00000595618.1	+	28	4898	c.4746G>A	c.(4744-4746)caG>caA	p.Q1582Q	MYO9B_ENST00000594824.1_Silent_p.Q1582Q|MYO9B_ENST00000397274.2_Silent_p.Q1582Q	NM_001130065.1|NM_004145.3	NP_001123537.1|NP_004136.2	Q13459	MYO9B_HUMAN	myosin IXB	1582	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(3)|endometrium(9)|kidney(2)|large_intestine(1)|lung(19)|soft_tissue(1)|urinary_tract(4)	39						AGCGTGGCCAGAAGGACACCA	0.562000													5	12					0	0	0.014758	0	0
SLC39A2	29986	broad.mit.edu	37	14	21468323	21468323	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr14:21468323C>T	ENST00000298681.4	+	3	452	c.295C>T	c.(295-297)Cat>Tat	p.H99Y	SLC39A2_ENST00000554422.1_3'UTR	NM_014579.3	NP_055394.2	Q9NP94	S39A2_HUMAN	solute carrier family 39 (zinc transporter), member 2	99						cytoplasmic membrane-bounded vesicle|integral to plasma membrane	zinc ion transmembrane transporter activity			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	14	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0187)		TGATTCAGCTCATGTAAGTAC	0.463000													7	41					0	0	0.004482	0	0
PPP1R14C	81706	broad.mit.edu	37	6	150464574	150464574	+	Silent	SNP	G	G	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr6:150464574G>T	ENST00000361131.4	+	1	363	c.246G>T	c.(244-246)cgG>cgT	p.R82R		NM_030949.2	NP_112211.1	Q8TAE6	PP14C_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 14C	82					regulation of phosphorylation	cytoplasm|membrane				endometrium(1)|large_intestine(1)|prostate(1)	3		Ovarian(120;0.0284)	BRCA - Breast invasive adenocarcinoma(37;0.215)	OV - Ovarian serous cystadenocarcinoma(155;9.14e-12)		AGGAGCTTCGGAAGCGGCTGG	0.647000													7	16					0.000157383	0.00016246	0.003080	1	0
OR10Q1	219960	broad.mit.edu	37	11	57995529	57995529	+	Silent	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr11:57995529C>T	ENST00000316770.2	-	1	861	c.819G>A	c.(817-819)gaG>gaA	p.E273E		NM_001004471.2	NP_001004471.1	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q, member 1	273					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)	35		Breast(21;0.0589)				TGTCCTCATCCTCTGAGGTGC	0.572000													30	38					0	0	0.008361	0	0
OXER1	165140	broad.mit.edu	37	2	42991084	42991084	+	Missense_Mutation	SNP	G	G	C			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr2:42991084G>C	ENST00000378661.2	-	1	317	c.236C>G	c.(235-237)tCt>tGt	p.S79C		NM_148962.4	NP_683765.1	Q8TDS5	OXER1_HUMAN	oxoeicosanoid (OXE) receptor 1	79	Ser-rich.				regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)	10						GGGCCCTCCAGAGGACCCCCC	0.627000													9	20					0	0	0.006214	0	0
CNTRL	11064	broad.mit.edu	37	9	123936008	123936008	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr9:123936008G>A	ENST00000373855.1	+	42	7000	c.6740G>A	c.(6739-6741)cGa>cAa	p.R2247Q	CNTRL_ENST00000238341.5_Missense_Mutation_p.R2247Q|CNTRL_ENST00000373850.1_Missense_Mutation_p.R1695Q|CNTRL_ENST00000373845.2_3'UTR			Q7Z7A1	CNTRL_HUMAN	centriolin	2247	Sufficient for interaction with HOOK2.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						CGGGAAGACCGACTCAAGGTT	0.463000													18	108					0	0	0.006122	0	0
MRS2	57380	broad.mit.edu	37	6	24409748	24409748	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr6:24409748C>T	ENST00000378386.3	+	4	454	c.361C>T	c.(361-363)Cag>Tag	p.Q121*	MRS2_ENST00000543597.1_5'UTR|MRS2_ENST00000443868.2_Nonsense_Mutation_p.Q121*|MRS2_ENST00000378353.1_Nonsense_Mutation_p.Q121*|MRS2_ENST00000535061.1_Intron|MRS2_ENST00000483634.1_Intron|MRS2_ENST00000274747.7_Intron	NM_020662.2	NP_065713.1	Q9HD23	MRS2_HUMAN	MRS2 magnesium transporter	121					ion transport	integral to membrane|mitochondrial inner membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)|stomach(1)	12						TTTGAGATTTCAGCATGTAAT	0.303000													5	68					0	0	0.001984	0	0
PIBF1	10464	broad.mit.edu	37	13	73539420	73539420	+	Missense_Mutation	SNP	A	A	C			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr13:73539420A>C	ENST00000326291.6	+	15	2180	c.1842A>C	c.(1840-1842)agA>agC	p.R614S		NM_006346.2	NP_006337.2	Q8WXW3	PIBF1_HUMAN	progesterone immunomodulatory binding factor 1	614				DLEHRKDQVTQLSQELDR -> RSGTSKGPSNTAFTRSLTE (in Ref. 3; AAQ67659).		centrosome				breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24		Prostate(6;0.00191)|Breast(118;0.0736)|Acute lymphoblastic leukemia(28;0.0865)		GBM - Glioblastoma multiforme(99;0.000664)		AGCTTGACAGAGCCAATTCGC	0.343000													10	29					0	0	0.013537	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				18	53					0	0	0.007413	0	0
PPFIA3	8541	broad.mit.edu	37	19	49651468	49651468	+	Silent	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr19:49651468C>T	ENST00000334186.4	+	24	3313	c.2964C>T	c.(2962-2964)aaC>aaT	p.N988N	PPFIA3_ENST00000602351.1_Silent_p.N979N	NM_003660.2	NP_003651.1	O75145	LIPA3_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	988	SAM 2.					cell surface|cytoplasm	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(16)|pancreas(1)|prostate(1)|skin(4)|urinary_tract(1)	35		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		ATCACCTTAACAAGAAGGAGC	0.612000													8	30					0	0	0.003080	0	0
WHSC1L1	54904	broad.mit.edu	37	8	38205277	38205277	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr8:38205277G>A	ENST00000317025.8	-	2	930	c.413C>T	c.(412-414)tCg>tTg	p.S138L	WHSC1L1_ENST00000527502.1_Missense_Mutation_p.S138L|WHSC1L1_ENST00000433384.2_Missense_Mutation_p.S138L|WHSC1L1_ENST00000316985.3_Missense_Mutation_p.S138L	NM_023034.1	NP_075447.1	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1	138					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			TTGTGGTACCGAAGGAGGAGG	0.418000			T	NUP98	AML								23	79					0	0	0.016522	0	0
PNCK	139728	broad.mit.edu	37	X	152937598	152937598	+	Silent	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chrX:152937598G>A	ENST00000393831.2	-	4	692	c.258C>T	c.(256-258)ctC>ctT	p.L86L	PNCK_ENST00000370145.4_Silent_p.L103L|PNCK_ENST00000370150.1_Silent_p.L86L|PNCK_ENST00000340888.3_Silent_p.L86L|PNCK_ENST00000447676.2_Silent_p.L169L|PNCK_ENST00000475172.1_5'UTR|PNCK_ENST00000370142.1_Silent_p.L86L	NM_001039582.3	NP_001034671.3	Q6P2M8	KCC1B_HUMAN	pregnancy up-regulated nonubiquitous CaM kinase	86	Protein kinase.					cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity	p.L86L(1)|p.L103L(1)|p.L115L(1)		breast(2)|lung(3)|skin(1)	6	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGGCCAGGTAGAGGTGGGAAG	0.637000													6	22					0	0	0.001984	0	0
RASD2	23551	broad.mit.edu	37	22	35947855	35947855	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr22:35947855C>T	ENST00000216127.4	+	3	1219	c.577C>T	c.(577-579)Cca>Tca	p.P193S		NM_014310.3	NP_055125.2	Q96D21	RHES_HUMAN	RASD family, member 2	193	Interaction with GNB1, GNB2 and GNB3.				locomotory behavior|positive regulation of protein kinase B signaling cascade|positive regulation of protein sumoylation|regulation of cAMP-mediated signaling	intracellular|plasma membrane	G-protein beta-subunit binding|GTP binding|GTPase activity			endometrium(2)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	13						GGCCAAGCTGCCACACGAGAT	0.612000													3	34					0	0	0.004672	0	0
HLA-A	3105	broad.mit.edu	37	6	29910607	29910607	+	Silent	SNP	G	G	C	rs72555397		TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr6:29910607G>C	ENST00000396634.1	+	4	488	c.147G>C	c.(145-147)gtG>gtC	p.V49V	HLA-A_ENST00000376806.5_Silent_p.V49V|HLA-A_ENST00000376802.2_Silent_p.V49V|HLA-A_ENST00000376809.5_Silent_p.V49V			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	49	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity	p.V49V(2)		central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						TCATCGCCGTGGGCTACGTGG	0.692000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			3	29					0	0	0.004672	0	0
CYC1	1537	broad.mit.edu	37	8	145150862	145150862	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr8:145150862G>A	ENST00000318911.4	+	2	329	c.256G>A	c.(256-258)Gac>Aac	p.D86N		NM_001916.3	NP_001907.2	P08574	CY1_HUMAN	cytochrome c-1	86					respiratory electron transport chain|transport	cell junction|integral to membrane|mitochondrial inner membrane|respiratory chain	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|heme binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)	15	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;8.71e-40)|all cancers(56;3e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GAGTGCCAGTGACCTGGAGCT	0.672000											OREG0019052	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	44					0	0	0.001984	0	0
ZDHHC14	79683	broad.mit.edu	37	6	157803239	157803239	+	Silent	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr6:157803239C>T	ENST00000359775.5	+	1	1075	c.186C>T	c.(184-186)ggC>ggT	p.G62G	ZDHHC14_ENST00000414563.2_Silent_p.G62G			Q8IZN3	ZDH14_HUMAN	zinc finger, DHHC-type containing 14	62						integral to membrane	acyltransferase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	17		Breast(66;0.00586)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.9e-17)|BRCA - Breast invasive adenocarcinoma(81;5.8e-05)		GGCAGACGGGCGTCTTCTACC	0.592000													18	36					0	0	0.007413	0	0
FAM171B	165215	broad.mit.edu	37	2	187559053	187559053	+	Silent	SNP	A	A	G	rs2370706		TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr2:187559053A>G	ENST00000304698.5	+	1	356	c.153A>G	c.(151-153)caA>caG	p.Q51Q	AC017101.10_ENST00000453665.1_RNA	NM_177454.3	NP_803237.3	Q6P995	F171B_HUMAN	family with sequence similarity 171, member B	51	Gln-rich.					integral to membrane	DNA binding			NS(1)|breast(6)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(22)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						agcagcaacaacaacaacaac	0.632000													3	21					0	0	0.004672	0	0
SUPT20H	55578	broad.mit.edu	37	13	37622068	37622068	+	Silent	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr13:37622068G>A	ENST00000360252.4	-	4	292	c.45C>T	c.(43-45)gtC>gtT	p.V15V	SUPT20H_ENST00000470359.2_5'UTR|SUPT20H_ENST00000464744.1_Silent_p.V15V|SUPT20H_ENST00000356185.3_Silent_p.V15V|SUPT20H_ENST00000475892.1_Silent_p.V15V|SUPT20H_ENST00000350612.6_Silent_p.V15V|SUPT20H_ENST00000542180.1_Silent_p.V3V	NM_001278481.1|NM_001278482.1|NM_017569.3	NP_001265410.1|NP_001265411.1|NP_060039.1			suppressor of Ty 20 homolog (S. cerevisiae)																		CACTTTCAATGACATACTAAA	0.318000													6	52					0	0	0.001168	0	0
SNX31	169166	broad.mit.edu	37	8	101661544	101661544	+	Silent	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr8:101661544G>A	ENST00000311812.2	-	2	249	c.99C>T	c.(97-99)ttC>ttT	p.F33F		NM_152628.3	NP_689841.3	Q8N9S9	SNX31_HUMAN	sorting nexin 31	33	PX.				cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			GCACCCTGCAGAAGAGGAACC	0.612000													4	34					0	0	0.014758	0	0
PPFIA3	8541	broad.mit.edu	37	19	49651468	49651468	+	Silent	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr19:49651468C>T	ENST00000334186.4	+	24	3313	c.2964C>T	c.(2962-2964)aaC>aaT	p.N988N	PPFIA3_ENST00000602351.1_Silent_p.N979N	NM_003660.2	NP_003651.1	O75145	LIPA3_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	988	SAM 2.					cell surface|cytoplasm	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(16)|pancreas(1)|prostate(1)|skin(4)|urinary_tract(1)	35		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		ATCACCTTAACAAGAAGGAGC	0.612000													8	30					0	0	0.003080	0	0
NKX2-1	7080	broad.mit.edu	37	14	36988488	36988488	+	Missense_Mutation	SNP	C	C	G			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr14:36988488C>G	ENST00000518149.1	-	2	680	c.75G>C	c.(73-75)aaG>aaC	p.K25N	NKX2-1_ENST00000522719.2_Missense_Mutation_p.K25N|NKX2-1_ENST00000498187.2_Missense_Mutation_p.K25N|NKX2-1-AS1_ENST00000521292.2_RNA|NKX2-1_ENST00000354822.5_Missense_Mutation_p.K55N|RP11-896J10.3_ENST00000521945.1_RNA			P43699	NKX21_HUMAN	NK2 homeobox 1	25					epithelial tube branching involved in lung morphogenesis|globus pallidus development|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|thyroid gland development		protein binding|transcription regulatory region DNA binding			large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(2)	7	all_cancers(3;4.47e-51)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.165)		Lung(8;1.8e-08)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.014)|all cancers(34;0.0366)|LUSC - Lung squamous cell carcinoma(13;0.132)	GBM - Glioblastoma multiforme(112;0.0171)		TGCCCACTTTCTTGTAGCTTT	0.652000			A		NSCLC								3	20					0	0	0.009096	0	0
OR2C1	4993	broad.mit.edu	37	16	3405956	3405956	+	Missense_Mutation	SNP	G	G	C			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr16:3405956G>C	ENST00000304936.2	+	1	68	c.16G>C	c.(16-18)Gat>Cat	p.D6H		NM_012368.2	NP_036500.2	O95371	OR2C1_HUMAN	olfactory receptor, family 2, subfamily C, member 1	6					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|liver(1)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						CGGGGTGAATGATAGCTCCTT	0.463000													9	42					0	0	0.006214	0	0
SLC13A5	284111	broad.mit.edu	37	17	6607201	6607201	+	Silent	SNP	C	C	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr17:6607201C>A	ENST00000433363.2	-	4	776	c.543G>T	c.(541-543)ctG>ctT	p.L181L	SLC13A5_ENST00000293800.6_Silent_p.L164L|SLC13A5_ENST00000573648.1_Silent_p.L181L|SLC13A5_ENST00000381074.4_Silent_p.L138L	NM_177550.3	NP_808218.1	Q86YT5	S13A5_HUMAN	solute carrier family 13 (sodium-dependent citrate transporter), member 5	181						integral to membrane	citrate transmembrane transporter activity	p.L181L(3)		breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|prostate(5)|skin(3)|urinary_tract(1)	26						GCTCACCTGGCAGCTCCTTGG	0.642000													5	22					5.9392e-07	6.29915e-07	0.001168	1	0
SPC25	57405	broad.mit.edu	37	2	169732647	169732647	+	Missense_Mutation	SNP	T	T	C			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr2:169732647T>C	ENST00000282074.2	-	5	527	c.386A>G	c.(385-387)aAa>aGa	p.K129R		NM_020675.3	NP_065726.1	Q9HBM1	SPC25_HUMAN	SPC25, NDC80 kinetochore complex component	129	Interaction with the N-terminus of SPBC24.				cell division|chromosome segregation|mitotic prometaphase|mitotic spindle organization	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(3)|urinary_tract(1)	9						CTGCAGCCTTTTCAACCTCTC	0.289000													2	17					0	0	0.004672	0	0
PHF23	79142	broad.mit.edu	37	17	7139847	7139847	+	Silent	SNP	G	G	C			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr17:7139847G>C	ENST00000320316.3	-	4	625	c.399C>G	c.(397-399)ctC>ctG	p.L133L	PHF23_ENST00000454255.2_Silent_p.L129L|PHF23_ENST00000571362.1_Silent_p.L66L|PHF23_ENST00000576955.1_Silent_p.L3L	NM_024297.2	NP_077273.2	Q9BUL5	PHF23_HUMAN	PHD finger protein 23	133							zinc ion binding			breast(4)|kidney(2)|large_intestine(6)|lung(3)	15						GAGAGTCCTTGAGCTTCATCT	0.602000													11	65					0	0	0.010729	0	0
OXER1	165140	broad.mit.edu	37	2	42991172	42991172	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr2:42991172G>A	ENST00000378661.2	-	1	229	c.148C>T	c.(148-150)Ccc>Tcc	p.P50S		NM_148962.4	NP_683765.1	Q8TDS5	OXER1_HUMAN	oxoeicosanoid (OXE) receptor 1	50	Ser-rich.				regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)	10						gagagagagggagatggagag	0.602000													6	39					0	0	0.001984	0	0
IGSF22	283284	broad.mit.edu	37	11	18741432	18741432	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr11:18741432G>A	ENST00000513874.1	-	7	666	c.527C>T	c.(526-528)cCt>cTt	p.P176L	RP11-1081L13.4_ENST00000527285.1_RNA	NM_173588.3	NP_775859.3	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	176	Lys-rich.									NS(2)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(20)|ovary(4)|prostate(4)|skin(3)	56						CTTGGGAGCAGGGGGTGCCCT	0.502000													7	117					0	0	0.001984	0	0
ABHD2	11057	broad.mit.edu	37	15	89659640	89659640	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr15:89659640G>A	ENST00000352732.5	+	3	602	c.82G>A	c.(82-84)Gtg>Atg	p.V28M	ABHD2_ENST00000565973.1_Missense_Mutation_p.V28M|ABHD2_ENST00000355100.3_Missense_Mutation_p.V28M	NM_152924.4	NP_690888.1	P08910	ABHD2_HUMAN	abhydrolase domain containing 2	28						integral to membrane	carboxylesterase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|soft_tissue(1)	23	Lung NSC(78;0.0472)|all_lung(78;0.089)					TGTGCTGTACGTGATCGTCCG	0.577000													34	59					0	0	0.015359	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000330386.6_Silent_p.Q2644Q|EP400_ENST00000332482.4_Silent_p.Q2688Q|EP400_ENST00000389561.2_Silent_p.Q2725Q|EP400_ENST00000389562.2_Silent_p.Q2724Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													3	42					0	0	0.014758	0	0
ST8SIA1	6489	broad.mit.edu	37	12	22487068	22487068	+	Silent	SNP	A	A	G			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr12:22487068A>G	ENST00000396037.4	-	1	580	c.99T>C	c.(97-99)agT>agC	p.S33S	ST8SIA1_ENST00000536558.1_Intron|ST8SIA1_ENST00000381424.3_Silent_p.S33S|ST8SIA1_ENST00000539510.1_5'UTR|ST8SIA1_ENST00000404299.3_Silent_p.S33S	NM_003034.3	NP_003025.1	Q92185	SIA8A_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	33					glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	25						CACAGAGGGCACTGGCTCCCA	0.667000													29	72					0	0	0.008361	0	0
MYF5	4617	broad.mit.edu	37	12	81112653	81112653	+	Silent	SNP	T	T	C			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr12:81112653T>C	ENST00000228644.3	+	3	743	c.591T>C	c.(589-591)gaT>gaC	p.D197D		NM_005593.2	NP_005584.2	P13349	MYF5_HUMAN	myogenic factor 5	197					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(8)|lung(15)|ovary(2)|pancreas(1)	30						ATGCCACAGATAAAAACTCCT	0.423000													34	60					0	0	0.021022	0	0
TDGF1P3	0	broad.mit.edu	37	X	109764445	109764445	+	RNA	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chrX:109764445G>A	ENST00000602699.1	+	0	906					NR_002718.2																						ATTAGTTGCCGGGCTGGGCCA	0.522000													11	31					0	0	0.013537	0	0
MDN1	23195	broad.mit.edu	37	6	90400467	90400467	+	Silent	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr6:90400467C>T	ENST00000369393.3	-	64	10789	c.10674G>A	c.(10672-10674)agG>agA	p.R3558R	MDN1_ENST00000428876.1_Silent_p.R3558R			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	3558					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TCCTAGAGTTCCTGCTCCTGT	0.517000													6	42					0	0	0.001984	0	0
SWSAP1	126074	broad.mit.edu	37	19	11486194	11486194	+	Silent	SNP	C	C	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr19:11486194C>A	ENST00000312423.2	+	2	251	c.192C>A	c.(190-192)atC>atA	p.I64I		NM_175871.3	NP_787067.2	Q6NVH7	CS039_HUMAN	SWIM-type zinc finger 7 associated protein 1	64																	TCTAGAAGATCCGCTTCCAGT	0.587000													80	134					4.64247e-43	5.0777e-43	0.014410	1	0
LINC00969	0	broad.mit.edu	37	3	195400728	195400728	+	RNA	SNP	A	A	G	rs12107841	by1000genomes	TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr3:195400728A>G	ENST00000445430.1	+	0	1324																											GATTGTGCCCAGCCTGTACGC	0.587000													3	16					0	0	0.009096	0	0
OXER1	165140	broad.mit.edu	37	2	42991137	42991137	+	Silent	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr2:42991137G>A	ENST00000378661.2	-	1	264	c.183C>T	c.(181-183)ttC>ttT	p.F61F		NM_148962.4	NP_683765.1	Q8TDS5	OXER1_HUMAN	oxoeicosanoid (OXE) receptor 1	61	Ser-rich.				regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)	10						gtgagggagagaaggagggag	0.612000													8	20					0	0	0.003080	0	0
ALOX12B	242	broad.mit.edu	37	17	7977036	7977036	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr17:7977036C>T	ENST00000319144.4	-	13	1954	c.1694G>A	c.(1693-1695)cGa>cAa	p.R565Q	ALOX12B_ENST00000577351.1_Intron	NM_001139.2	NP_001130.1	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	565	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	16						AGTGACATATCGGATCAGCTC	0.622000										Multiple Myeloma(8;0.094)	OREG0024152	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	20					0	0	0.004672	0	0
NFE2L3	9603	broad.mit.edu	37	7	26224243	26224243	+	Missense_Mutation	SNP	A	A	G	rs144296822	byFrequency	TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr7:26224243A>G	ENST00000056233.3	+	4	1184	c.925A>G	c.(925-927)Ata>Gta	p.I309V		NM_004289.6	NP_004280.5	Q9Y4A8	NF2L3_HUMAN	nuclear factor, erythroid 2-like 3	309					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(5)|urinary_tract(7)	29						CAGCCAGGCTATAAGTCAGGA	0.423000													43	70					0	0	0.008740	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S164S|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								4	51					0	0	0.014758	0	0
AL031666.2	0	broad.mit.edu	37	20	45947814	45947814	+	Silent	SNP	A	A	G			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr20:45947814A>G	ENST00000599904.1	+	1	569	c.450A>G	c.(448-450)ggA>ggG	p.G150G	ZMYND8_ENST00000262975.4_Intron|ZMYND8_ENST00000396281.4_Intron|ZMYND8_ENST00000471951.2_Intron|ZMYND8_ENST00000536340.1_Intron|ZMYND8_ENST00000311275.7_Intron|ZMYND8_ENST00000540497.1_Intron|ZMYND8_ENST00000360911.3_Intron|ZMYND8_ENST00000461685.1_Intron|ZMYND8_ENST00000355972.4_Intron|ZMYND8_ENST00000352431.2_Intron|ZMYND8_ENST00000446994.2_Intron|ZMYND8_ENST00000372023.3_Intron|ZMYND8_ENST00000458360.2_Intron																							TCCCAGGGGGAGGAGGAAGAA	0.592000													2	7					0	0	0.004672	0	0
PHF23	79142	broad.mit.edu	37	17	7139630	7139630	+	Missense_Mutation	SNP	G	G	C			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr17:7139630G>C	ENST00000320316.3	-	4	842	c.616C>G	c.(616-618)Cct>Gct	p.P206A	PHF23_ENST00000454255.2_Missense_Mutation_p.P202A|PHF23_ENST00000571362.1_Missense_Mutation_p.P139A|PHF23_ENST00000576955.1_Missense_Mutation_p.P76A	NM_024297.2	NP_077273.2	Q9BUL5	PHF23_HUMAN	PHD finger protein 23	206							zinc ion binding			breast(4)|kidney(2)|large_intestine(6)|lung(3)	15						CCATCCCCAGGAGTTGGCCGA	0.582000													17	76					0	0	0.004007	0	0
TAF7L	54457	broad.mit.edu	37	X	100547854	100547854	+	Translation_Start_Site	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chrX:100547854G>A	ENST00000372905.2	-	0	205				TAF7L_ENST00000372907.3_Silent_p.D60D			Q5H9L4	TAF7L_HUMAN	TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa						cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			NS(1)|breast(4)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						GAGTGTCCTCGTCGGCAGGAA	0.562000													65	27					0	0	0.014410	0	0
FA2H	79152	broad.mit.edu	37	16	74750252	74750252	+	Missense_Mutation	SNP	C	C	G			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr16:74750252C>G	ENST00000219368.3	-	6	1101	c.1032G>C	c.(1030-1032)caG>caC	p.Q344H	FA2H_ENST00000544337.1_Missense_Mutation_p.Q131H	NM_024306.4	NP_077282.3	Q7L5A8	FA2H_HUMAN	fatty acid 2-hydroxylase	344					cell death|electron transport chain|fatty acid biosynthetic process|sphingolipid metabolic process|transport	endoplasmic reticulum membrane|integral to membrane|microsome	heme binding|oxidoreductase activity			endometrium(2)|large_intestine(4)|lung(3)|skin(1)	10						CACCTGACTTCTGATGTGCAA	0.542000													7	42					0	0	0.003080	0	0
CSAG4	0	broad.mit.edu	37	X	151896589	151896589	+	RNA	SNP	C	C	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chrX:151896589C>A	ENST00000361201.4	-	0	351					NR_073432.1													p.L11F(1)		endometrium(2)|kidney(2)|lung(1)	5						GGTTGTTGGACAATGGGCTGG	0.557000													4	72					0.00024832	0.000255624	0.009096	1	0
KIAA0319L	79932	broad.mit.edu	37	1	35915475	35915475	+	Silent	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr1:35915475C>T	ENST00000325722.3	-	15	2580	c.2346G>A	c.(2344-2346)gtG>gtA	p.V782V	KIAA0319L_ENST00000485551.1_5'UTR|KIAA0319L_ENST00000373266.4_Silent_p.V219V	NM_024874.4	NP_079150.3	Q8IZA0	K319L_HUMAN	KIAA0319-like	782	PKD 5.					cytoplasmic vesicle part|integral to membrane	protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(12)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	34		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CACCAGGTTTCACCTCCACAG	0.493000													11	44					0	0	0.010729	0	0
KHNYN	23351	broad.mit.edu	37	14	24900883	24900883	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr14:24900883C>T	ENST00000251343.5	+	3	555	c.416C>T	c.(415-417)gCa>gTa	p.A139V	KHNYN_ENST00000556842.1_Missense_Mutation_p.A139V|KHNYN_ENST00000553935.1_Missense_Mutation_p.A139V			O15037	KHNYN_HUMAN	KH and NYN domain containing	139										kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(3)|pancreas(1)|prostate(3)	24						GAAGAGCTGGCAGAGCGGCTG	0.622000											OREG0022627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	55					0	0	0.003080	0	0
UNC13A	23025	broad.mit.edu	37	19	17756912	17756912	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr19:17756912C>T	ENST00000428389.2	-	19	2316	c.2317G>A	c.(2317-2319)Gcc>Acc	p.A773T	UNC13A_ENST00000252773.7_Missense_Mutation_p.A685T|UNC13A_ENST00000519716.2_Missense_Mutation_p.A685T|UNC13A_ENST00000550896.1_Missense_Mutation_p.A683T|UNC13A_ENST00000552293.1_Missense_Mutation_p.A685T|UNC13A_ENST00000551649.1_Missense_Mutation_p.A685T			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	685					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding	p.A685T(1)		breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						AAGCCCTGGGCGCAGACCACT	0.557000													5	23					0	0	0.001168	0	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39261693	39261693	+	Missense_Mutation	SNP	A	A	T	rs113059833	by1000genomes	TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr17:39261693A>T	ENST00000391415.1	+	1	110	c.53A>T	c.(52-54)gAc>gTc	p.D18V		NM_001146041.1	NP_001139513.1	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	18						keratin filament		p.D18V(1)		central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|urinary_tract(3)	14						TGCGGCCAAGACCTCTGTCAG	0.627000													5	29					0	0	0.001984	0	0
ATG14	22863	broad.mit.edu	37	14	55848817	55848817	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr14:55848817G>A	ENST00000247178.5	-	6	775	c.740C>T	c.(739-741)tCa>tTa	p.S247L		NM_014924.4	NP_055739.2	Q6ZNE5	BAKOR_HUMAN	autophagy related 14	247					autophagic vacuole assembly|positive regulation of autophagy	autophagic vacuole|endoplasmic reticulum|pre-autophagosomal structure membrane	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(2)	13						CCATCGTCCTGAGAGGTAAGT	0.532000													21	81					0	0	0.014323	0	0
SLC34A2	10568	broad.mit.edu	37	4	25678361	25678361	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr4:25678361C>T	ENST00000382051.3	+	13	2113	c.2063C>T	c.(2062-2064)aCg>aTg	p.T688M	SLC34A2_ENST00000504570.1_Missense_Mutation_p.T687M|SLC34A2_ENST00000503434.1_Missense_Mutation_p.T687M	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	688					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				ACCGAATGCACGGCCTTGTAG	0.567000			T	ROS1	NSCLC								20	33					0	0	0.008871	0	0
TTBK2	146057	broad.mit.edu	37	15	43067809	43067809	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr15:43067809C>T	ENST00000267890.6	-	13	1630	c.1522G>A	c.(1522-1524)Gat>Aat	p.D508N		NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	508					cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		TATTCTTCATCATAGTGCCAG	0.502000													12	80					0	0	0.013537	0	0
CREB3L3	84699	broad.mit.edu	37	19	4154971	4154971	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr19:4154971G>A	ENST00000078445.2	+	2	250	c.103G>A	c.(103-105)Ggc>Agc	p.G35S	CREB3L3_ENST00000252587.3_Missense_Mutation_p.G26S|CREB3L3_ENST00000595923.1_Missense_Mutation_p.G35S|CREB3L3_ENST00000602257.1_Missense_Mutation_p.G35S|CREB3L3_ENST00000602147.1_Missense_Mutation_p.G35S	NM_001271995.1|NM_001271996.1|NM_032607.1	NP_001258924.1|NP_001258925.1|NP_115996.1	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like 3	35					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(2)|urinary_tract(3)	24				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGGCAGGACGGCATCCTGAG	0.637000													26	63					0	0	0.007291	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701879	56701879	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr19:56701879C>T	ENST00000586855.2	-	5	1118	c.805G>A	c.(805-807)Gac>Aac	p.D269N	ZSCAN5B_ENST00000358992.3_Missense_Mutation_p.D269N			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	269					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						GAAGGTGTGTCAGCATCCACA	0.502000													24	111					0	0	0.016522	0	0
TYMP	1890	broad.mit.edu	37	22	50967746	50967746	+	Missense_Mutation	SNP	C	C	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr22:50967746C>A	ENST00000252029.3	-	3	398	c.236G>T	c.(235-237)cGa>cTa	p.R79L	TYMP_ENST00000395678.3_Missense_Mutation_p.R79L|TYMP_ENST00000395680.1_Missense_Mutation_p.R79L|TYMP_ENST00000395681.1_Missense_Mutation_p.R79L	NM_001113755.2|NM_001113756.2|NM_001257988.1|NM_001257989.1|NM_001953.4	NP_001107227.1|NP_001107228.1|NP_001244917.1|NP_001244918.1|NP_001944.1	P19971	TYPH_HUMAN	thymidine phosphorylase	79					angiogenesis|cell differentiation|chemotaxis|DNA replication|mitochondrial genome maintenance|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol	growth factor activity|platelet-derived growth factor receptor binding|pyrimidine-nucleoside phosphorylase activity|thymidine phosphorylase activity			large_intestine(1)|lung(2)|ovary(1)|prostate(1)	5		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)	Capecitabine(DB01101)|Docetaxel(DB01248)|Floxuridine(DB00322)|Fluorouracil(DB00544)|Sulfasalazine(DB00795)|Tamoxifen(DB00675)	GCCCCGAAGTCGGATGGCCAT	0.692000													13	26					1.5842e-08	1.70606e-08	0.016723	1	0
MYO9B	4650	broad.mit.edu	37	19	17313022	17313022	+	Silent	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr19:17313022G>A	ENST00000595618.1	+	28	4898	c.4746G>A	c.(4744-4746)caG>caA	p.Q1582Q	MYO9B_ENST00000594824.1_Silent_p.Q1582Q|MYO9B_ENST00000397274.2_Silent_p.Q1582Q	NM_001130065.1|NM_004145.3	NP_001123537.1|NP_004136.2	Q13459	MYO9B_HUMAN	myosin IXB	1582	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(3)|endometrium(9)|kidney(2)|large_intestine(1)|lung(19)|soft_tissue(1)|urinary_tract(4)	39						AGCGTGGCCAGAAGGACACCA	0.562000													5	12					0	0	0.014758	0	0
SLC39A2	29986	broad.mit.edu	37	14	21468323	21468323	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr14:21468323C>T	ENST00000298681.4	+	3	452	c.295C>T	c.(295-297)Cat>Tat	p.H99Y	SLC39A2_ENST00000554422.1_3'UTR	NM_014579.3	NP_055394.2	Q9NP94	S39A2_HUMAN	solute carrier family 39 (zinc transporter), member 2	99						cytoplasmic membrane-bounded vesicle|integral to plasma membrane	zinc ion transmembrane transporter activity			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	14	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0187)		TGATTCAGCTCATGTAAGTAC	0.463000													7	41					0	0	0.004482	0	0
PPP1R14C	81706	broad.mit.edu	37	6	150464574	150464574	+	Silent	SNP	G	G	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr6:150464574G>T	ENST00000361131.4	+	1	363	c.246G>T	c.(244-246)cgG>cgT	p.R82R		NM_030949.2	NP_112211.1	Q8TAE6	PP14C_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 14C	82					regulation of phosphorylation	cytoplasm|membrane				endometrium(1)|large_intestine(1)|prostate(1)	3		Ovarian(120;0.0284)	BRCA - Breast invasive adenocarcinoma(37;0.215)	OV - Ovarian serous cystadenocarcinoma(155;9.14e-12)		AGGAGCTTCGGAAGCGGCTGG	0.647000													7	16					0.000157383	0.00016443	0.003080	1	0
OR10Q1	219960	broad.mit.edu	37	11	57995529	57995529	+	Silent	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr11:57995529C>T	ENST00000316770.2	-	1	861	c.819G>A	c.(817-819)gaG>gaA	p.E273E		NM_001004471.2	NP_001004471.1	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q, member 1	273					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)	35		Breast(21;0.0589)				TGTCCTCATCCTCTGAGGTGC	0.572000													30	38					0	0	0.008361	0	0
OXER1	165140	broad.mit.edu	37	2	42991084	42991084	+	Missense_Mutation	SNP	G	G	C			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr2:42991084G>C	ENST00000378661.2	-	1	317	c.236C>G	c.(235-237)tCt>tGt	p.S79C		NM_148962.4	NP_683765.1	Q8TDS5	OXER1_HUMAN	oxoeicosanoid (OXE) receptor 1	79	Ser-rich.				regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)	10						GGGCCCTCCAGAGGACCCCCC	0.627000													9	20					0	0	0.006214	0	0
CNTRL	11064	broad.mit.edu	37	9	123936008	123936008	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr9:123936008G>A	ENST00000373855.1	+	42	7000	c.6740G>A	c.(6739-6741)cGa>cAa	p.R2247Q	CNTRL_ENST00000238341.5_Missense_Mutation_p.R2247Q|CNTRL_ENST00000373845.2_3'UTR|CNTRL_ENST00000373850.1_Missense_Mutation_p.R1695Q			Q7Z7A1	CNTRL_HUMAN	centriolin	2247	Sufficient for interaction with HOOK2.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						CGGGAAGACCGACTCAAGGTT	0.463000													18	108					0	0	0.006122	0	0
MRS2	57380	broad.mit.edu	37	6	24409748	24409748	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr6:24409748C>T	ENST00000378386.3	+	4	454	c.361C>T	c.(361-363)Cag>Tag	p.Q121*	MRS2_ENST00000378353.1_Nonsense_Mutation_p.Q121*|MRS2_ENST00000443868.2_Nonsense_Mutation_p.Q121*|MRS2_ENST00000483634.1_Intron|MRS2_ENST00000543597.1_5'UTR|MRS2_ENST00000535061.1_Intron|MRS2_ENST00000274747.7_Intron	NM_020662.2	NP_065713.1	Q9HD23	MRS2_HUMAN	MRS2 magnesium transporter	121					ion transport	integral to membrane|mitochondrial inner membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)|stomach(1)	12						TTTGAGATTTCAGCATGTAAT	0.303000													5	68					0	0	0.001984	0	0
PIBF1	10464	broad.mit.edu	37	13	73539420	73539420	+	Missense_Mutation	SNP	A	A	C			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr13:73539420A>C	ENST00000326291.6	+	15	2180	c.1842A>C	c.(1840-1842)agA>agC	p.R614S		NM_006346.2	NP_006337.2	Q8WXW3	PIBF1_HUMAN	progesterone immunomodulatory binding factor 1	614				DLEHRKDQVTQLSQELDR -> RSGTSKGPSNTAFTRSLTE (in Ref. 3; AAQ67659).		centrosome				breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24		Prostate(6;0.00191)|Breast(118;0.0736)|Acute lymphoblastic leukemia(28;0.0865)		GBM - Glioblastoma multiforme(99;0.000664)		AGCTTGACAGAGCCAATTCGC	0.343000													10	29					0	0	0.013537	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				18	53					0	0	0.007413	0	0
WHSC1L1	54904	broad.mit.edu	37	8	38205277	38205277	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr8:38205277G>A	ENST00000317025.8	-	2	930	c.413C>T	c.(412-414)tCg>tTg	p.S138L	WHSC1L1_ENST00000527502.1_Missense_Mutation_p.S138L|WHSC1L1_ENST00000433384.2_Missense_Mutation_p.S138L|WHSC1L1_ENST00000316985.3_Missense_Mutation_p.S138L	NM_023034.1	NP_075447.1	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1	138					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			TTGTGGTACCGAAGGAGGAGG	0.418000			T	NUP98	AML								23	79					0	0	0.016522	0	0
PNCK	139728	broad.mit.edu	37	X	152937598	152937598	+	Silent	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chrX:152937598G>A	ENST00000393831.2	-	4	692	c.258C>T	c.(256-258)ctC>ctT	p.L86L	PNCK_ENST00000370150.1_Silent_p.L86L|PNCK_ENST00000340888.3_Silent_p.L86L|PNCK_ENST00000447676.2_Silent_p.L169L|PNCK_ENST00000370142.1_Silent_p.L86L|PNCK_ENST00000475172.1_5'UTR|PNCK_ENST00000370145.4_Silent_p.L103L	NM_001039582.3	NP_001034671.3	Q6P2M8	KCC1B_HUMAN	pregnancy up-regulated nonubiquitous CaM kinase	86	Protein kinase.					cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity	p.L86L(1)|p.L103L(1)|p.L115L(1)		breast(2)|lung(3)|skin(1)	6	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGGCCAGGTAGAGGTGGGAAG	0.637000													6	22					0	0	0.001984	0	0
RASD2	23551	broad.mit.edu	37	22	35947855	35947855	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr22:35947855C>T	ENST00000216127.4	+	3	1219	c.577C>T	c.(577-579)Cca>Tca	p.P193S		NM_014310.3	NP_055125.2	Q96D21	RHES_HUMAN	RASD family, member 2	193	Interaction with GNB1, GNB2 and GNB3.				locomotory behavior|positive regulation of protein kinase B signaling cascade|positive regulation of protein sumoylation|regulation of cAMP-mediated signaling	intracellular|plasma membrane	G-protein beta-subunit binding|GTP binding|GTPase activity			endometrium(2)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	13						GGCCAAGCTGCCACACGAGAT	0.612000													3	34					0	0	0.004672	0	0
HLA-A	3105	broad.mit.edu	37	6	29910607	29910607	+	Silent	SNP	G	G	C	rs72555397		TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr6:29910607G>C	ENST00000396634.1	+	4	488	c.147G>C	c.(145-147)gtG>gtC	p.V49V	HLA-A_ENST00000376802.2_Silent_p.V49V|HLA-A_ENST00000376806.5_Silent_p.V49V|HLA-A_ENST00000376809.5_Silent_p.V49V			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	49	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity	p.V49V(2)		central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						TCATCGCCGTGGGCTACGTGG	0.692000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			3	29					0	0	0.004672	0	0
CYC1	1537	broad.mit.edu	37	8	145150862	145150862	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr8:145150862G>A	ENST00000318911.4	+	2	329	c.256G>A	c.(256-258)Gac>Aac	p.D86N		NM_001916.3	NP_001907.2	P08574	CY1_HUMAN	cytochrome c-1	86					respiratory electron transport chain|transport	cell junction|integral to membrane|mitochondrial inner membrane|respiratory chain	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|heme binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)	15	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;8.71e-40)|all cancers(56;3e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GAGTGCCAGTGACCTGGAGCT	0.672000											OREG0019052	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	44					0	0	0.001984	0	0
ZDHHC14	79683	broad.mit.edu	37	6	157803239	157803239	+	Silent	SNP	C	C	T			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr6:157803239C>T	ENST00000359775.5	+	1	1075	c.186C>T	c.(184-186)ggC>ggT	p.G62G	ZDHHC14_ENST00000414563.2_Silent_p.G62G			Q8IZN3	ZDH14_HUMAN	zinc finger, DHHC-type containing 14	62						integral to membrane	acyltransferase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	17		Breast(66;0.00586)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.9e-17)|BRCA - Breast invasive adenocarcinoma(81;5.8e-05)		GGCAGACGGGCGTCTTCTACC	0.592000													18	36					0	0	0.007413	0	0
RP11-13J8.1	0	broad.mit.edu	37	2	201967217	201967218	+	RNA	DEL	AG	AG	-			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr2:201967217_201967218delAG	ENST00000448256.1	+	0	627_628																											aaaaaaaaaaagaaTTTGTTCT	0.460													2	4	---	---	---	---					
LINC00969	0	broad.mit.edu	37	3	195400639	195400641	+	RNA	DEL	GTG	GTG	-	rs145880653		TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr3:195400639_195400641delGTG	ENST00000445430.1	+	0	1284																											AGGTGGGCTTGTGGAGGAATGGG	0.552													2	4	---	---	---	---					
RAB11FIP2	22841	broad.mit.edu	37	10	119798740	119798740	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr10:119798740delC	ENST00000355624.3	-	3	1447	c.1008delG	c.(1006-1008)atfs	p.M336fs	RP11-354M20.3_ENST00000451610.2_RNA|RAB11FIP2_ENST00000369199.3_Frame_Shift_Del_p.M336fs	NM_014904.2	NP_055719.1	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2 (class I)	336					protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(8)	19		Colorectal(252;0.235)		all cancers(201;0.0238)		AAAATAAATTCATGCTGCTGT	0.343													32	70	---	---	---	---					
SIRT2	22933	broad.mit.edu	37	19	39370317	39370317	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	055f269a-df3a-4063-a414-59e6a33cbba2	g.chr19:39370317delA	ENST00000249396.7	-	14	1203	c.902delT	c.(901-903)agfs	p.M301fs	SIRT2_ENST00000358931.5_Intron|SIRT2_ENST00000392081.2_Frame_Shift_Del_p.M264fs	NM_012237.3	NP_036369.2	Q8IXJ6	SIRT2_HUMAN	sirtuin 2	301	Deacetylase sirtuin-type.				cell division|chromatin silencing at rDNA|chromatin silencing at telomere|mitosis|negative regulation of striated muscle tissue development|protein ADP-ribosylation|regulation of exit from mitosis|regulation of phosphorylation|response to redox state	chromatin silencing complex|cytoplasm|microtubule	histone acetyltransferase binding|histone deacetylase binding|NAD+ binding|NAD-dependent histone deacetylase activity|transcription factor binding|tubulin deacetylase activity|ubiquitin binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(5)|skin(1)	9	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00125)|LUSC - Lung squamous cell carcinoma(53;0.00191)			TCCGAGGCCCATAATCATCCC	0.652													2	4	---	---	---	---					
AC007040.8	0	broad.mit.edu	37	2	71283122	71283123	+	RNA	INS	-	-	T	rs35074164		TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr2:71283122_71283123insT	ENST00000434990.1	-	0	61																											GGCACCACCCCCAGGAGTGGTG	0.530													4	4	---	---	---	---					
RAB11FIP2	22841	broad.mit.edu	37	10	119798740	119798740	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr10:119798740delC	ENST00000355624.3	-	3	1447	c.1008delG	c.(1006-1008)atfs	p.M336fs	RAB11FIP2_ENST00000369199.3_Frame_Shift_Del_p.M336fs|RP11-354M20.3_ENST00000451610.2_RNA	NM_014904.2	NP_055719.1	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2 (class I)	336					protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(8)	19		Colorectal(252;0.235)		all cancers(201;0.0238)		AAAATAAATTCATGCTGCTGT	0.343													32	70	---	---	---	---					
EMG1	10436	broad.mit.edu	37	12	7080210	7080211	+	RNA	INS	-	-	G	rs141646579	by1000genomes	TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr12:7080210_7080211insG	ENST00000546220.1	+	0	155_156				U47924.28_ENST00000261406.6_lincRNA|U47924.19_ENST00000564245.1_RNA			Q92979	NEP1_HUMAN	EMG1 N1-specific pseudouridine methyltransferase						ribosomal small subunit biogenesis	cytoplasm|nucleolus	rRNA (pseudouridine) methyltransferase activity|rRNA binding										CGGAGGCCGTAGTTTATTGTGG	0.569													8	9	---	---	---	---					
RP11-493L12.5	0	broad.mit.edu	37	12	47761313	47761314	+	RNA	INS	-	-	T	rs57593482		TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr12:47761313_47761314insT	ENST00000550019.1	+	0	262																											ttcgctctctattttttttttt	0.406													5	9	---	---	---	---					
SIRT2	22933	broad.mit.edu	37	19	39370317	39370317	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BJ-A2NA-01A-12D-A19J-08	TCGA-BJ-A2NA-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3fb47f70-88d5-4b3e-821e-cee5eb717471	c88a3e4d-4316-4bc3-b2fa-0ac3dd76e558	g.chr19:39370317delA	ENST00000249396.7	-	14	1203	c.902delT	c.(901-903)agfs	p.M301fs	SIRT2_ENST00000392081.2_Frame_Shift_Del_p.M264fs|SIRT2_ENST00000358931.5_Intron	NM_012237.3	NP_036369.2	Q8IXJ6	SIRT2_HUMAN	sirtuin 2	301	Deacetylase sirtuin-type.				cell division|chromatin silencing at rDNA|chromatin silencing at telomere|mitosis|negative regulation of striated muscle tissue development|protein ADP-ribosylation|regulation of exit from mitosis|regulation of phosphorylation|response to redox state	chromatin silencing complex|cytoplasm|microtubule	histone acetyltransferase binding|histone deacetylase binding|NAD+ binding|NAD-dependent histone deacetylase activity|transcription factor binding|tubulin deacetylase activity|ubiquitin binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(5)|skin(1)	9	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00125)|LUSC - Lung squamous cell carcinoma(53;0.00191)			TCCGAGGCCCATAATCATCCC	0.652													2	4	---	---	---	---