Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CORO7	79585	broad.mit.edu	37	16	4409369	4409369	+	Missense_Mutation	SNP	G	G	C			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr16:4409369G>C	ENST00000251166.4	-	23	2413	c.2268C>G	c.(2266-2268)ttC>ttG	p.F756L	CORO7_ENST00000539968.1_Missense_Mutation_p.F536L|CORO7_ENST00000574025.1_Missense_Mutation_p.F671L|CORO7_ENST00000537233.2_Missense_Mutation_p.F738L|CORO7-PAM16_ENST00000572467.1_Missense_Mutation_p.F756L	NM_024535.4	NP_078811.3			coronin 7											breast(3)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|prostate(2)|skin(2)|urinary_tract(2)	23						GCTCGTACAGGAATACACGGG	0.667000											OREG0023580	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	28					0	0	0.003080	0	0
FAM179A	165186	broad.mit.edu	37	2	29274814	29274814	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr2:29274814C>T	ENST00000379558.4	+	20	3266	c.2915C>T	c.(2914-2916)gCc>gTc	p.A972V	FAM179A_ENST00000465300.1_3'UTR|FAM179A_ENST00000403861.2_Missense_Mutation_p.A917V	NM_199280.2	NP_954974.2	Q6ZUX3	F179A_HUMAN	family with sequence similarity 179, member A	972							binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						CTGGACTTTGCCGCCAGCCAG	0.657000													3	27					0	0	0.004672	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128840216	128840216	+	Missense_Mutation	SNP	A	A	C			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr11:128840216A>C	ENST00000310343.9	-	22	4849	c.4850T>G	c.(4849-4851)cTg>cGg	p.L1617R	ARHGAP32_ENST00000392657.3_Missense_Mutation_p.L1268R|ARHGAP32_ENST00000524655.1_3'UTR|ARHGAP32_ENST00000527272.1_Missense_Mutation_p.L1268R	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	1617	Interaction with GAB2.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						ATATTGGTACAGAGGTCTTGG	0.522000													44	44					0	0	0.008740	0	0
PTPRD	5789	broad.mit.edu	37	9	8465600	8465600	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr9:8465600C>T	ENST00000381196.4	-	29	4123	c.3580G>A	c.(3580-3582)Gct>Act	p.A1194T	PTPRD_ENST00000540109.1_Missense_Mutation_p.A1194T|PTPRD_ENST00000537002.1_Missense_Mutation_p.A780T|PTPRD_ENST00000486161.1_Missense_Mutation_p.A783T|PTPRD_ENST00000355233.5_Missense_Mutation_p.A783T|PTPRD_ENST00000397611.3_Missense_Mutation_p.A780T|PTPRD_ENST00000397606.3_Missense_Mutation_p.A773T|PTPRD_ENST00000397617.3_Missense_Mutation_p.A773T|PTPRD_ENST00000358503.5_Missense_Mutation_p.A1172T|PTPRD_ENST00000356435.5_Missense_Mutation_p.A1194T|PTPRD_ENST00000360074.4_Missense_Mutation_p.A1181T	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1194					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TCAAAGTGAGCGGCAATATAT	0.428000										TSP Lung(15;0.13)			54	98					0	0	0.003610	0	0
TRBV7-8	0	broad.mit.edu	37	7	142099660	142099660	+	RNA	SNP	G	G	A			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr7:142099660G>A	ENST00000390359.3	-	0	180																											AGGGATACATGACCCGAAATT	0.517000													8	112					0	0	0.003080	0	0
FAT4	79633	broad.mit.edu	37	4	126336901	126336901	+	Silent	SNP	A	A	G			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr4:126336901A>G	ENST00000394329.3	+	5	6796	c.6783A>G	c.(6781-6783)ctA>ctG	p.L2261L	FAT4_ENST00000335110.5_Silent_p.L559L	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2261	Cadherin 22.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TATTTGAGCTATCTCCATATT	0.388000													9	104					0	0	0.006214	0	0
DNAH1	25981	broad.mit.edu	37	3	52388985	52388985	+	Missense_Mutation	SNP	A	A	G			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr3:52388985A>G	ENST00000420323.2	+	21	3868	c.3607A>G	c.(3607-3609)Atg>Gtg	p.M1203V		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	1203	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CCACATCGTCATGACCCAGAA	0.557000													33	68					0	0	0.003755	0	0
UGT2A1	10941	broad.mit.edu	37	4	70460903	70460903	+	Missense_Mutation	SNP	C	C	A			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr4:70460903C>A	ENST00000503640.1	-	4	1116	c.1061G>T	c.(1060-1062)tGg>tTg	p.W354L	UGT2A1_ENST00000514019.1_Missense_Mutation_p.W520L|UGT2A2_ENST00000457664.2_Missense_Mutation_p.W363L|UGT2A1_ENST00000286604.4_Missense_Mutation_p.W354L|UGT2A1_ENST00000512704.1_Missense_Mutation_p.W310L|UGT2A1_ENST00000502343.1_5'UTR	NM_006798.3	NP_006789.2	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus	354					detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						CTGGGGTATCCAATCAAAGAG	0.363000													17	127					3.32936e-07	4.2806e-07	0.006122	1	0
ZNF626	199777	broad.mit.edu	37	19	20807787	20807787	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr19:20807787G>A	ENST00000601440.1	-	4	1042	c.896C>T	c.(895-897)aCc>aTc	p.T299I	CTC-513N18.7_ENST00000595094.1_lincRNA	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	299					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						TGTAGTAAGGGTTGAGGACCG	0.368000													4	210					0	0	0.001168	0	0
ZFYVE16	9765	broad.mit.edu	37	5	79768579	79768579	+	Splice_Site	SNP	G	G	T			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr5:79768579G>T	ENST00000338008.5	+	15	4204		c.e15-1		ZFYVE16_ENST00000510158.1_Splice_Site|ZFYVE16_ENST00000505560.1_Splice_Site	NM_014733.3	NP_055548.3	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16						BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity			breast(4)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|liver(1)|lung(6)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		CTCATTTCTAGATGGCTTAAT	0.348000													36	82					2.51966e-14	3.30705e-14	0.003610	1	0
ZNF626	199777	broad.mit.edu	37	19	20807796	20807796	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr19:20807796C>T	ENST00000601440.1	-	4	1033	c.887G>A	c.(886-888)cGg>cAg	p.R296Q	CTC-513N18.7_ENST00000595094.1_lincRNA	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	296					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						GGTTGAGGACCGGTTGAAGGC	0.388000													4	206					0	0	0.001168	0	0
BNC1	646	broad.mit.edu	37	15	83935700	83935700	+	Missense_Mutation	SNP	A	A	G			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr15:83935700A>G	ENST00000345382.2	-	3	408	c.323T>C	c.(322-324)cTa>cCa	p.L108P	BNC1_ENST00000569704.1_Missense_Mutation_p.L101P|RP11-382A20.4_ENST00000565495.1_RNA	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	108					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						TAGGATTTTTAGGCGAACGGG	0.502000													3	151					0	0	0.004672	0	0
NDC80	10403	broad.mit.edu	37	18	2599022	2599022	+	Missense_Mutation	SNP	A	A	G			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr18:2599022A>G	ENST00000261597.4	+	12	1408	c.1226A>G	c.(1225-1227)gAa>gGa	p.E409G		NM_006101.2	NP_006092.1	O14777	NDC80_HUMAN	NDC80 kinetochore complex component	409	Interaction with NEK2 and ZWINT.|Interaction with PSMC2 and SMC1A.|Interaction with SMC1A.|Interaction with the N-terminus of CDCA1.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			NS(1)|biliary_tract(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(2)|urinary_tract(2)	22						TTACAGATTGAAACACAATTA	0.289000													35	69					0	0	0.002836	0	0
HLA-DPB1	3115	broad.mit.edu	37	6	33043841	33043841	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr6:33043841C>T	ENST00000418931.2	+	1	139	c.23C>T	c.(22-24)gCg>gTg	p.A8V	HLA-DPA1_ENST00000419277.1_Intron|HLA-DPB1_ENST00000535465.1_Missense_Mutation_p.A8V	NM_002121.5	NP_002112.3	P04440	DPB1_HUMAN	major histocompatibility complex, class II, DP beta 1	8					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to membrane|lysosomal membrane|MHC class II protein complex				cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	11						CAGGTTTCTGCGGCCCCCCGG	0.547000													3	40					0	0	0.004672	0	0
MAGEE1	57692	broad.mit.edu	37	X	75650162	75650162	+	Silent	SNP	G	G	A			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chrX:75650162G>A	ENST00000361470.2	+	1	2117	c.1839G>A	c.(1837-1839)caG>caA	p.Q613Q		NM_020932.2	NP_065983.1	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	613	MAGE 1.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	51						TGGGGGTGCAGCGGGAAAGGA	0.493000													6	84					0	0	0.001168	0	0
ITSN1	6453	broad.mit.edu	37	21	35255856	35255856	+	Silent	SNP	T	T	C			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr21:35255856T>C	ENST00000381318.3	+	36	4845	c.4557T>C	c.(4555-4557)ccT>ccC	p.P1519P	ITSN1_ENST00000399367.3_Silent_p.P1514P|ITSN1_ENST00000437442.2_Silent_p.P1458P|ITSN1_ENST00000381285.4_Silent_p.P1519P|AP000304.12_ENST00000429238.1_Intron|ITSN1_ENST00000399326.3_3'UTR	NM_003024.2	NP_003015.2	Q15811	ITSN1_HUMAN	intersectin 1 (SH3 domain protein)	1519	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(26)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	67						CTTTCCAGCCTATTTTCCTAA	0.498000													3	243					0	0	0.004672	0	0
LINC00264	0	broad.mit.edu	37	10	26880338	26880338	+	RNA	SNP	G	G	C	rs3118888	by1000genomes	TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr10:26880338G>C	ENST00000412114.1	+	0	573					NR_026793.1																						GCTGAAACATGGAAGGTAAAA	0.483000													3	31					0	0	0.000248	0	0
TGFBI	7045	broad.mit.edu	37	5	135390519	135390519	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr5:135390519G>A	ENST00000442011.2	+	10	1540	c.1379G>A	c.(1378-1380)gGc>gAc	p.G460D	TGFBI_ENST00000305126.8_Missense_Mutation_p.G460D	NM_000358.2	NP_000349.1	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	460	FAS1 3.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding	p.G460D(1)		breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ACTCTGGGCGGCAAAAAACTG	0.423000													6	356					0	0	0.001984	0	0
OR4C6	219432	broad.mit.edu	37	11	55433283	55433283	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr11:55433283C>T	ENST00000314259.3	+	1	670	c.641C>T	c.(640-642)gCg>gTg	p.A214V		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	214					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						ATCTTAATTGCGTCCTACACG	0.522000													23	163					0	0	0.002299	0	0
NLRX1	79671	broad.mit.edu	37	11	119053828	119053828	+	Splice_Site	SNP	C	C	T			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr11:119053828C>T	ENST00000409109.1	+	10	3195	c.2606_splice	c.e10-1	p.L870_splice	NLRX1_ENST00000525863.1_Intron|NLRX1_ENST00000469103.2_3'UTR|NLRX1_ENST00000292199.2_Splice_Site_p.L870_splice|NLRX1_ENST00000409991.1_Splice_Site_p.L870_splice|NLRX1_ENST00000409265.4_Intron			Q86UT6	NLRX1_HUMAN	NLR family member X1	870	Required for the repression of MAVS- induced interferon signaling.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			cervix(1)|endometrium(2)|kidney(2)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	22	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		TCCTGCCAGCCTCTACTTCAA	0.592000													10	36					0	0	0.008291	0	0
FAM196A	642938	broad.mit.edu	37	10	128974640	128974640	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr10:128974640C>T	ENST00000522781.1	-	4	575	c.20G>A	c.(19-21)gGc>gAc	p.G7D	FAM196A_ENST00000424811.2_Missense_Mutation_p.G7D|DOCK1_ENST00000280333.6_Intron	NM_001039762.2	NP_001034851.1	Q6ZSG2	F196A_HUMAN	family with sequence similarity 196, member A	7										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						TATGCATTTGCCGGTGTCCTT	0.527000													4	238					0	0	0.000248	0	0
GOSR1	9527	broad.mit.edu	37	17	28811716	28811716	+	Silent	SNP	C	C	T			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr17:28811716C>T	ENST00000225724.5	+	4	348	c.276C>T	c.(274-276)acC>acT	p.T92T	GOSR1_ENST00000467337.2_Silent_p.T27T|GOSR1_ENST00000451249.2_Silent_p.T90T|GOSR1_ENST00000581721.1_Silent_p.T92T	NM_001007024.1|NM_001007025.1|NM_004871.2	NP_001007025.1|NP_001007026.1|NP_004862.1	O95249	GOSR1_HUMAN	golgi SNAP receptor complex member 1	92					intra-Golgi vesicle-mediated transport|protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane|SNARE complex	SNAP receptor activity			endometrium(2)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)	12						CAGAATATACCAACAGTGCAG	0.363000													12	70					0	0	0.001368	0	0
SDHAP1	0	broad.mit.edu	37	3	195698264	195698264	+	RNA	SNP	T	T	C	rs12485654	by1000genomes	TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr3:195698264T>C	ENST00000427841.1	-	0	1608					NR_003264.2																						TTTGTCAACATTCGTGACAGA	0.413000													3	97					0	0	0.000602	0	0
PPARA	5465	broad.mit.edu	37	22	46627935	46627935	+	Missense_Mutation	SNP	A	A	G			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr22:46627935A>G	ENST00000396000.2	+	7	1223	c.958A>G	c.(958-960)Atg>Gtg	p.M320V	PPARA_ENST00000402126.1_Missense_Mutation_p.M320V|PPARA_ENST00000407236.1_Missense_Mutation_p.M320V|PPARA_ENST00000434345.2_3'UTR|PPARA_ENST00000262735.5_Missense_Mutation_p.M320V			Q07869	PPARA_HUMAN	peroxisome proliferator-activated receptor alpha	320	Ligand-binding.|Required for heterodimerization with RXRA.				fatty acid metabolic process|fatty acid transport|negative regulation of appetite|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fatty acid beta-oxidation|regulation of cellular ketone metabolic process by positive regulation of transcription from an RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|ligand-regulated transcription factor activity|lipid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|ubiquitin conjugating enzyme binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	15		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00522)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Clofibrate(DB00636)|Fenofibrate(DB01039)|Gemfibrozil(DB01241)|Simvastatin(DB00641)	CATATTCGCCATGCTGTCTTC	0.463000													14	231					0	0	0.004007	0	0
RRP7B	0	broad.mit.edu	37	22	42971987	42971987	+	RNA	SNP	T	T	C	rs137064	by1000genomes	TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr22:42971987T>C	ENST00000357802.2	-	0	733																		p.Q59R(1)									CAGCTCTTTTTGGCTGCGCTT	0.672000													3	35					0	0	0.004672	0	0
ZNF804B	219578	broad.mit.edu	37	7	88962796	88962796	+	Missense_Mutation	SNP	T	T	C			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr7:88962796T>C	ENST00000333190.4	+	4	1109	c.500T>C	c.(499-501)cTc>cCc	p.L167P		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	167						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			AGTGCTCTTCTCCTTAAAGGA	0.443000										HNSCC(36;0.09)			4	107					0	0	0.000248	0	0
SDHAP1	0	broad.mit.edu	37	3	195698262	195698262	+	RNA	SNP	C	C	G	rs28503679	by1000genomes	TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr3:195698262C>G	ENST00000427841.1	-	0	1610					NR_003264.2																						AATTTGTCAACATTCGTGACA	0.418000													3	102					0	0	0.000602	0	0
SCAI	286205	broad.mit.edu	37	9	127790688	127790688	+	Missense_Mutation	SNP	C	C	A			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr9:127790688C>A	ENST00000336505.5	-	5	454	c.396G>T	c.(394-396)caG>caT	p.Q132H	SCAI_ENST00000373549.4_Missense_Mutation_p.Q155H	NM_001144877.2	NP_001138349.1	Q8N9R8	SCAI_HUMAN	suppressor of cancer cell invasion	132	Necessary to inhibit MKL1-induced SRF transcriptional activity (By similarity).|Required for interaction with MKL1 (By similarity).				negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|integral to membrane|nucleus	protein binding|transcription corepressor activity	p.Q155H(9)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(7)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|prostate(5)|stomach(1)|urinary_tract(1)	35						GATAGTATAGCTGCCCAATCT	0.338000													12	111					4.84862e-15	6.49921e-15	0.000978	1	0
LRRC8A	56262	broad.mit.edu	37	9	131670524	131670524	+	Missense_Mutation	SNP	A	A	C			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr9:131670524A>C	ENST00000259324.5	+	3	1604	c.1081A>C	c.(1081-1083)Agc>Cgc	p.S361R	LRRC8A_ENST00000372599.3_Missense_Mutation_p.S361R|LRRC8A_ENST00000372600.4_Missense_Mutation_p.S361R	NM_001127244.1	NP_001120716.1	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member A	361					pre-B cell differentiation	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(3)	28						TGAGGAGAGCAGCTACAGCGA	0.547000													39	62					0	0	0.003610	0	0
CPNE5	57699	broad.mit.edu	37	6	36710082	36710082	+	Missense_Mutation	SNP	C	C	T	rs3830138	byFrequency	TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr6:36710082C>T	ENST00000244751.2	-	21	2369	c.1745G>A	c.(1744-1746)cGc>cAc	p.R582H	CPNE5_ENST00000459703.1_5'UTR|CPNE5_ENST00000393189.2_Missense_Mutation_p.R290H	NM_020939.1	NP_065990.1	Q9HCH3	CPNE5_HUMAN	copine V	582			R -> H (in dbSNP:rs3830138).							central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(4)|liver(1)|lung(9)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25						AGGGGGCGTGCGGGCTGGGGA	0.687000													4	72					0	0	0.000248	0	0
CSMD2	114784	broad.mit.edu	37	1	34089026	34089026	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr1:34089026G>T	ENST00000373381.4	-	36	5842	c.5666C>A	c.(5665-5667)tCg>tAg	p.S1889*	CSMD2_ENST00000373388.2_5'UTR|CSMD2_ENST00000373377.1_5'UTR|CSMD2_ENST00000373380.1_Nonsense_Mutation_p.S762*	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1849	CUB 11.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TACTTCCAGCGAGTCCCAGTT	0.502000													50	82					2.73381e-35	3.74413e-35	0.003610	1	0
HS3ST1	9957	broad.mit.edu	37	4	11400850	11400850	+	Silent	SNP	G	G	A			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr4:11400850G>A	ENST00000002596.5	-	2	1954	c.780C>T	c.(778-780)agC>agT	p.S260S		NM_005114.2	NP_005105.1	O14792	HS3S1_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	260						Golgi lumen|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(6)|skin(3)	15						GGTCCCGGCCGCTGTCCCGCA	0.502000													6	125					0	0	0.001168	0	0
DIO1	1733	broad.mit.edu	37	1	54360073	54360073	+	Missense_Mutation	SNP	A	A	G	rs143572229		TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr1:54360073A>G	ENST00000361921.3	+	1	214	c.190A>G	c.(190-192)Acc>Gcc	p.T64A	DIO1_ENST00000388876.3_Missense_Mutation_p.T64A|DIO1_ENST00000322679.6_Missense_Mutation_p.T64A|DIO1_ENST00000525202.1_Intron|DIO1_ENST00000524406.1_Intron|DIO1_ENST00000534069.1_3'UTR|DIO1_ENST00000532493.1_Missense_Mutation_p.T64A	NM_000792.5|NM_213593.3	NP_000783.2|NP_998758.1	P49895	IOD1_HUMAN	deiodinase, iodothyronine, type I	64					hormone biosynthetic process|thyroid hormone generation	endoplasmic reticulum membrane|integral to membrane|plasma membrane	selenium binding|thyroxine 5'-deiodinase activity			cervix(1)|endometrium(2)|large_intestine(3)|lung(2)|skin(1)	9						CTGGATACCAACCTTTTTCAG	0.547000													69	139					0	0	0.003610	0	0
PABPN1	8106	broad.mit.edu	37	14	23792253	23792253	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr14:23792253C>T	ENST00000397276.2	+	3	525	c.512C>T	c.(511-513)gCc>gTc	p.A171V	PABPN1_ENST00000216727.4_Missense_Mutation_p.A171V|PABPN1_ENST00000556821.1_Missense_Mutation_p.A43V|PABPN1_ENST00000557702.1_Missense_Mutation_p.A43V|BCL2L2-PABPN1_ENST00000557008.1_Missense_Mutation_p.A198V|BCL2L2-PABPN1_ENST00000553781.1_Missense_Mutation_p.A198V					poly(A) binding protein, nuclear 1											large_intestine(1)|lung(1)|ovary(2)	4	all_cancers(95;6.69e-06)			GBM - Glioblastoma multiforme(265;0.00643)		GAGGCTGATGCCCGTTCCATC	0.438000													4	242					0	0	0.000602	0	0
AGAP10	728127	broad.mit.edu	37	10	47207813	47207813	+	Splice_Site	SNP	T	T	C			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr10:47207813T>C	ENST00000355232.3	-	5	3482	c.471_splice	c.e5+1	p.H157_splice	AGAP10_ENST00000452145.2_Splice_Site_p.H132_splice|RP11-144G6.12_ENST00000605970.1_RNA|AGAP10_ENST00000413193.2_Splice_Site_p.H228_splice					ArfGAP with GTPase domain, ankyrin repeat and PH domain 10									p.H228R(20)		endometrium(5)|kidney(3)|lung(1)|prostate(2)|urinary_tract(1)	12						TTTACTTACATGGTTTGTACA	0.294000													4	73					0	0	0.000602	0	0
UBB	7314	broad.mit.edu	37	17	16285560	16285560	+	Silent	SNP	T	T	C			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr17:16285560T>C	ENST00000302182.3	+	2	731	c.339T>C	c.(337-339)ccT>ccC	p.P113P	RP11-138I1.4_ENST00000583934.1_RNA|UBB_ENST00000395837.1_Silent_p.P113P|UBB_ENST00000395839.1_Silent_p.P113P|UBB_ENST00000578649.1_Intron|UBB_ENST00000535788.1_Intron	NM_018955.2	NP_061828.1	P0CG47	UBB_HUMAN	ubiquitin B	113	Ubiquitin-like 2.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		AAGGCATCCCTCCCGACCAGC	0.557000													4	197					0	0	0.000248	0	0
RP11-114H24.7	0	broad.mit.edu	37	15	78211648	78211648	+	RNA	SNP	A	A	G			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr15:78211648A>G	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CGCCAGGGATAGGGGCTCAGC	0.522000													4	88					0	0	0.001168	0	0
SUV420H2	84787	broad.mit.edu	37	19	55853326	55853326	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr19:55853326G>A	ENST00000255613.3	+	2	270	c.22G>A	c.(22-24)Gca>Aca	p.A8T	AC020922.1_ENST00000539076.1_5'UTR|SUV420H2_ENST00000402499.4_3'UTR	NM_032701.3	NP_116090.2	Q86Y97	SV422_HUMAN	suppressor of variegation 4-20 homolog 2 (Drosophila)	8					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)	4	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		CAGAGTGACAGCACGAGAACT	0.652000													9	143					0	0	0.006214	0	0
ZC3H14	79882	broad.mit.edu	37	14	89075665	89075665	+	Silent	SNP	T	T	C			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr14:89075665T>C	ENST00000251038.5	+	14	2148	c.1923T>C	c.(1921-1923)tgT>tgC	p.C641C	ZC3H14_ENST00000556945.1_Silent_p.C510C|ZC3H14_ENST00000555900.1_Silent_p.C343C|ZC3H14_ENST00000555755.1_Silent_p.C636C|ZC3H14_ENST00000557607.1_Silent_p.C330C|ZC3H14_ENST00000406216.3_Silent_p.C187C|ZC3H14_ENST00000393514.5_Silent_p.C616C|ZC3H14_ENST00000359301.3_Silent_p.C476C|ZC3H14_ENST00000336693.4_Silent_p.C476C|ZC3H14_ENST00000318308.6_Silent_p.C212C|ZC3H14_ENST00000302216.8_Silent_p.C485C	NM_001160103.1|NM_001160104.1|NM_024824.4	NP_001153575.1|NP_001153576.1|NP_079100.2	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14	641						cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			cervix(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(2)	21						ACCCAAATTGTAAATATGATG	0.358000													3	153					0	0	0.004672	0	0
C16orf58	64755	broad.mit.edu	37	16	31504977	31504977	+	Missense_Mutation	SNP	C	C	G			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr16:31504977C>G	ENST00000327237.2	-	8	944	c.905G>C	c.(904-906)aGg>aCg	p.R302T	C16orf58_ENST00000570164.1_Missense_Mutation_p.R300T|C16orf58_ENST00000430477.2_Missense_Mutation_p.R160T|C16orf58_ENST00000567994.1_Missense_Mutation_p.R257T			Q96GQ5	CP058_HUMAN	chromosome 16 open reading frame 58	302						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)	14						TACCTCTCCCCTCTGAAGGTA	0.632000													10	58					0	0	0.000978	0	0
CDHR5	53841	broad.mit.edu	37	11	624828	624828	+	Silent	SNP	G	G	T			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr11:624828G>T	ENST00000358353.3	-	2	397	c.75C>A	c.(73-75)gcC>gcA	p.A25A	CDHR5_ENST00000529337.1_Intron|CDHR5_ENST00000349570.7_Silent_p.A25A|CDHR5_ENST00000397542.2_Silent_p.A25A			Q9HBB8	CDHR5_HUMAN	cadherin-related family member 5	25					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	23						ACTGGGCCTGGGCCATGGTCC	0.701000													7	15					0.00198382	0.00240347	0.001984	1	0
ZNF106	64397	broad.mit.edu	37	15	42713287	42713287	+	Missense_Mutation	SNP	A	A	C			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr15:42713287A>C	ENST00000263805.4	-	17	5746	c.5420T>G	c.(5419-5421)cTt>cGt	p.L1807R	ZNF106_ENST00000565380.1_Missense_Mutation_p.L1035R|ZNF106_ENST00000565611.1_Missense_Mutation_p.L992R	NM_022473.1	NP_071918.1			zinc finger protein 106																		CATCAGATTAAGCCTCACGGC	0.413000													14	156					0	0	0.001855	0	0
MAP3K8	1326	broad.mit.edu	37	10	30736732	30736732	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr10:30736732C>T	ENST00000263056.1	+	4	1054	c.358C>T	c.(358-360)Cgt>Tgt	p.R120C	MAP3K8_ENST00000542547.1_Missense_Mutation_p.R120C|MAP3K8_ENST00000375321.1_Missense_Mutation_p.R120C	NM_001244134.1|NM_005204.3	NP_001231063.1|NP_005195.2	P41279	M3K8_HUMAN	mitogen-activated protein kinase kinase kinase 8	120					cell cycle|T cell costimulation	cytosol	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		Prostate(175;0.151)				CCAAAATGGACGTTACCAAAT	0.433000													80	122					0	0	0.003610	0	0
SASH1	23328	broad.mit.edu	37	6	148664242	148664243	+	In_Frame_Ins	INS	-	-	GAGCCC	rs76317765		TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr6:148664242_148664243insGAGCCC	ENST00000367467.3	+	1	514_515	c.39_40insGAGCCC	c.(37-42)ccagcc>ccGAGCCCagcc	p.12_13insPS	SASH1_ENST00000367469.1_Intron	NM_015278.3	NP_056093.3	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	12	Pro-rich.						protein binding			breast(4)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		ggccggagcctgagcccgagcc	0.792													4	7	---	---	---	---					
KRTAP5-5	439915	broad.mit.edu	37	11	1651199	1651228	+	In_Frame_Del	DEL	AGGCTGTGGGGGCTGTGGCTCCGGCTGTGC	AGGCTGTGGGGGCTGTGGCTCCGGCTGTGC	-	rs35089393	by1000genomes	TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr11:1651199_1651228delAGGCTGTGGGGGCTGTGGCTCCGGCTGTGC	ENST00000399676.2	+	1	167_196	c.129_158delAGGCTGTGGGGGCTGTGGCTCCGGCTGTGC	c.(127-159)ggg>gg	p.GGCGGCGSGCA43del		NM_001001480.2	NP_001001480.2	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	43				G -> GGCGS (in Ref. 1; BAD20201 and 2; CAF31639).		keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|urinary_tract(1)	33		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		ccggctgtggaggctgtgggggctgtggctccggctgtgcgggctgtggg	0.691													11	58	---	---	---	---					
ONECUT1	3175	broad.mit.edu	37	15	53081466	53081467	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr15:53081466_53081467insG	ENST00000305901.5	-	1	742_743	c.615_616insC	c.(613-618)gcccatfs	p.H206fs	ONECUT1_ENST00000561401.2_Intron	NM_004498.2	NP_004489.1	Q9UBC0	HNF6_HUMAN	one cut homeobox 1	206					endocrine pancreas development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)|skin(1)	17				all cancers(107;0.0708)		GTGGGCATGGCGGCCCCCGGGT	0.713													11	172	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74378976	74378976	+	RNA	DEL	T	T	-	rs35591542		TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr16:74378976delT	ENST00000429810.2	-	0	1086																											ACCTCTTGAAttttttttttt	0.418													2	4	---	---	---	---					
RP13-329D4.3	0	broad.mit.edu	37	20	26113543	26113543	+	RNA	DEL	A	A	-			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr20:26113543delA	ENST00000416563.1	-	0	250																											TCTTTGCCTTAACAACATTAT	0.363													2	4	---	---	---	---					
CRYBB2P1	0	broad.mit.edu	37	22	25853204	25853205	+	RNA	INS	-	-	C			TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chr22:25853204_25853205insC	ENST00000354451.2	+	0	123																											CATACTCACTTCCCCCCATCCT	0.535													8	10	---	---	---	---					
VCX3B	0	broad.mit.edu	37	X	8434047	8434076	+	In_Frame_Del	DEL	GAACCACTGAGTCAGGAGAGCCAGGTGGAG	GAACCACTGAGTCAGGAGAGCCAGGTGGAG	-	rs5978241		TCGA-BJ-A0ZF-01A-11D-A10S-08	TCGA-BJ-A0ZF-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	362c568e-71ea-44ff-89a4-12f2a88c4134	36a50022-0a00-48e8-844d-92cf8c0758de	g.chrX:8434047_8434076delGAACCACTGAGTCAGGAGAGCCAGGTGGAG	ENST00000381032.1	+	3	671_700	c.364_393delGAACCACTGAGTCAGGAGAGCCAGGTGGAG	c.(364-393)del	p.EPLSQESQVE122del	VCX3B_ENST00000453306.1_In_Frame_Del_p.EPLSQESQVE122del|VCX3B_ENST00000381029.4_In_Frame_Del_p.EPLSQESQVE100del|VCX3B_ENST00000444481.1_Splice_Site_p.122_splice|VCX3B_ENST00000440654.2_Intron	NM_001001888.3	NP_001001888.3	Q9H321	VCX3B_HUMAN	variable charge, X-linked 3B	122	11 X 10 AA tandem repeats of L-S-Q-E-S- [EQ]-V-E-E-P.					nucleolus				NS(1)|large_intestine(1)|lung(2)|prostate(1)|skin(3)|urinary_tract(3)	11						CGAGGTGGAAGAACCACTGAGTCAGGAGAGCCAGGTGGAGGAACCACTGA	0.622													8	52	---	---	---	---