Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MIA2	117153	broad.mit.edu	37	14	39716388	39716388	+	Missense_Mutation	SNP	A	A	G			TCGA-IM-A3ED-01A-11D-A202-08	TCGA-IM-A3ED-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7d3599f-0218-4d1d-aed8-c45c188cd71d	ea16b689-e941-4ea0-ad31-9504e19ed28b	g.chr14:39716388A>G	uc001wux.3	+	3	804	c.610A>G	c.(610-612)Atg>Gtg	p.M204V	MIA2_uc010amy.2_Missense_Mutation_p.M135V	NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	Homo sapiens melanoma inhibitory activity 2 (MIA2), mRNA.	204						extracellular region				NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	31	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		TGTTGAAAGTATGGAACAGGA	0.433000													3	79					0	0	1	0	0
FBXW8	26259	broad.mit.edu	37	12	117402520	117402520	+	Silent	SNP	G	G	A			TCGA-IM-A3ED-01A-11D-A202-08	TCGA-IM-A3ED-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7d3599f-0218-4d1d-aed8-c45c188cd71d	ea16b689-e941-4ea0-ad31-9504e19ed28b	g.chr12:117402520G>A	uc001twg.1	+	4	778	c.696G>A	c.(694-696)gtG>gtA	p.V232V	FBXW8_uc001twf.1_Silent_p.V166V	NM_153348	NP_699179	Q8N3Y1	FBXW8_HUMAN	Homo sapiens F-box and WD repeat domain containing 8 (FBXW8), transcript variant 1, mRNA.	232							protein binding			endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	22	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0353)		CAGGGGATGTGAGAGTGTGGG	0.522000													75	183					0	0	1	0	0
EPHB6	2051	broad.mit.edu	37	7	142565403	142565403	+	Silent	SNP	G	G	C			TCGA-IM-A3ED-01A-11D-A202-08	TCGA-IM-A3ED-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7d3599f-0218-4d1d-aed8-c45c188cd71d	ea16b689-e941-4ea0-ad31-9504e19ed28b	g.chr7:142565403G>C	uc011kst.2	+	11	2575	c.1788G>C	c.(1786-1788)gtG>gtC	p.V596V	EPHB6_uc011ksu.2_Silent_p.V596V|EPHB6_uc003wbs.3_Silent_p.V304V|EPHB6_uc003wbt.3_Silent_p.V70V|EPHB6_uc003wbu.3_Silent_p.V304V|EPHB6_uc003wbv.3_5'UTR	NM_004445	NP_004436	O15197	EPHB6_HUMAN	Homo sapiens EPH receptor B6 (EPHB6), mRNA.	596						extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					TCTCCTTGGTGATCGGCTCCA	0.637000													10	12					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140953611	140953611	+	Silent	SNP	C	C	T			TCGA-IM-A3ED-01A-11D-A202-08	TCGA-IM-A3ED-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7d3599f-0218-4d1d-aed8-c45c188cd71d	ea16b689-e941-4ea0-ad31-9504e19ed28b	g.chr9:140953611C>T	uc004cog.3	+	29	4699	c.4554C>T	c.(4552-4554)tgC>tgT	p.C1518C	CACNA1B_uc022bqn.1_Silent_p.C1518C|CACNA1B_uc011mfd.2_Silent_p.C1119C|CACNA1B_uc004coi.3_Silent_p.C732C	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	Homo sapiens calcium channel, voltage-dependent, N type, alpha 1B subunit (CACNA1B), transcript variant 1, mRNA.	1518					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CCATGGAATGCGTGCTGAAGA	0.507000													13	15					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104432410	104432410	+	Missense_Mutation	SNP	C	C	T			TCGA-IM-A3ED-01A-11D-A202-08	TCGA-IM-A3ED-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7d3599f-0218-4d1d-aed8-c45c188cd71d	ea16b689-e941-4ea0-ad31-9504e19ed28b	g.chr9:104432410C>T	uc004bbp.2	-	2	2885	c.2284G>A	c.(2284-2286)Gca>Aca	p.A762T	GRIN3A_uc004bbq.1_Missense_Mutation_p.A762T	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	Homo sapiens glutamate receptor, ionotropic, N-methyl-D-aspartate 3A (GRIN3A), mRNA.	762					response to ethanol	N-methyl-D-aspartate selective glutamate receptor complex|cell junction|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	GCCAAGTTTGCCGTGTATGTG	0.418000													3	78					0	0	1	0	0
CLIC5	53405	broad.mit.edu	37	6	45917096	45917096	+	Missense_Mutation	SNP	G	G	C			TCGA-IM-A3ED-01A-11D-A202-08	TCGA-IM-A3ED-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7d3599f-0218-4d1d-aed8-c45c188cd71d	ea16b689-e941-4ea0-ad31-9504e19ed28b	g.chr6:45917096G>C	uc003oxv.3	-	2	779	c.673C>G	c.(673-675)Cta>Gta	p.L225V	CLIC5_uc003oxu.3_Missense_Mutation_p.L66V|CLIC5_uc003oxx.3_Missense_Mutation_p.L66V	NM_001114086	NP_001107558	Q9NZA1	CLIC5_HUMAN	Homo sapiens chloride intracellular channel 5 (CLIC5), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	225					female pregnancy	Golgi apparatus|actin cytoskeleton|cell cortex|chloride channel complex|insoluble fraction|microtubule organizing center	protein binding|voltage-gated chloride channel activity			endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	13						CCGGGGGCTAGGTTGTGCAGG	0.542000													48	80					0	0	1	0	0
NOTCH3	4854	broad.mit.edu	37	19	15289709	15289709	+	Silent	SNP	T	T	A			TCGA-IM-A3ED-01A-11D-A202-08	TCGA-IM-A3ED-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7d3599f-0218-4d1d-aed8-c45c188cd71d	ea16b689-e941-4ea0-ad31-9504e19ed28b	g.chr19:15289709T>A	uc002nan.3	-	22	3838	c.3762A>T	c.(3760-3762)ccA>ccT	p.P1254P	NOTCH3_uc002nao.1_Silent_p.P1202P	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Homo sapiens notch 3 (NOTCH3), mRNA.	1254	EGF-like 32.				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi lumen|cytosol|endoplasmic reticulum lumen|extracellular region|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CATGCTGGCATGGCTGGGACT	0.652000													5	12					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119944646	119944646	+	Missense_Mutation	SNP	T	T	G			TCGA-IM-A3ED-01A-11D-A202-08	TCGA-IM-A3ED-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7d3599f-0218-4d1d-aed8-c45c188cd71d	ea16b689-e941-4ea0-ad31-9504e19ed28b	g.chr4:119944646T>G	uc010inb.3	+	1	363	c.167T>G	c.(166-168)aTc>aGc	p.I56S	SYNPO2_uc010ina.3_Missense_Mutation_p.I56S|SYNPO2_uc003icm.4_Missense_Mutation_p.I56S|SYNPO2_uc011cgh.2_Missense_Mutation_p.I56S|SYNPO2_uc010inc.3_5'UTR	NM_133477	NP_597734	Q9UMS6	SYNP2_HUMAN	Homo sapiens synaptopodin 2 (SYNPO2), transcript variant 1, mRNA.	56	PDZ.					Z disc|nucleus	14-3-3 protein binding|actin binding|muscle alpha-actinin binding	p.I56I(1)		breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GTGGTTTCCATCAATGGCAAC	0.438000													3	80					0	0	1	0	0
KLHL32	114792	broad.mit.edu	37	6	97561919	97561919	+	Silent	SNP	G	G	A			TCGA-IM-A3ED-01A-11D-A202-08	TCGA-IM-A3ED-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7d3599f-0218-4d1d-aed8-c45c188cd71d	ea16b689-e941-4ea0-ad31-9504e19ed28b	g.chr6:97561919G>A	uc010kcm.1	+	6	1360	c.888G>A	c.(886-888)ggG>ggA	p.G296G	KLHL32_uc003poy.3_Silent_p.G296G|KLHL32_uc003poz.2_Intron|KLHL32_uc011ead.1_Silent_p.G260G|KLHL32_uc011eae.1_Silent_p.G227G|KLHL32_uc003ppa.2_Intron|MIR548H3_uc021zda.1_Intron	NM_052904	NP_443136	Q96NJ5	KLH32_HUMAN	Homo sapiens kelch-like 32 (Drosophila) (KLHL32), mRNA.	296										breast(2)|endometrium(3)|kidney(4)|large_intestine(9)|lung(13)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	38		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		TCATTGGTGGGAAAAAGCGCG	0.517000													18	44					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-IM-A3ED-01A-11D-A202-08	TCGA-IM-A3ED-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7d3599f-0218-4d1d-aed8-c45c188cd71d	ea16b689-e941-4ea0-ad31-9504e19ed28b	g.chr7:140453136A>T	uc003vwc.4	-	14	1860	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(41204)|p.V600K(615)|p.V600?(377)|p.V600R(99)|p.V600D(40)|p.V600_K601>E(30)|p.V600L(28)|p.V600A(24)|p.V600G(22)|p.V600M(22)|p.A598_T599insV(7)|p.T599_V600insT(7)|p.T599I(5)|p.V600Q(4)|p.T599_R603>I(4)|p.T599_V600insTT(3)|p.T599_V600insDFGLAT(2)|p.T599_V600>IAL(2)|p.V600_S605>EK(2)|p.T599T(2)|p.V600_S605>DV(2)|p.V600_S605>D(2)|p.V600_W604del(1)|p.V600V(1)|p.T599_V600insV(1)|p.V600>DLAT(1)|p.D594_T599del(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				25	61					0	0	1	0	0
TFAMP1	260341	broad.mit.edu	37	7	1654770	1654770	+	RNA	SNP	G	G	C			TCGA-IM-A3ED-01A-11D-A202-08	TCGA-IM-A3ED-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7d3599f-0218-4d1d-aed8-c45c188cd71d	ea16b689-e941-4ea0-ad31-9504e19ed28b	g.chr7:1654770G>C	uc003slb.3	+	0		c.665G>C								Homo sapiens transcription factor A, mitochondrial pseudogene 1 (TFAMP1), non-coding RNA.																		AGGCAAAGCTGAAGACTGTAA	0.333000													2	16					0	0	1	0	0
LCA5	167691	broad.mit.edu	37	6	80228599	80228599	+	Missense_Mutation	SNP	C	C	T			TCGA-IM-A3ED-01A-11D-A202-08	TCGA-IM-A3ED-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7d3599f-0218-4d1d-aed8-c45c188cd71d	ea16b689-e941-4ea0-ad31-9504e19ed28b	g.chr6:80228599C>T	uc003piy.3	-	2	625	c.13G>A	c.(13-15)Gca>Aca	p.A5T	LCA5_uc003pix.3_Missense_Mutation_p.A5T|LCA5_uc011dyr.2_Missense_Mutation_p.A5T	NM_181714	NP_859065	Q86VQ0	LCA5_HUMAN	Homo sapiens Leber congenital amaurosis 5 (LCA5), transcript variant 1, mRNA.	5					protein transport	cilium axoneme|microtubule basal body	protein binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	32		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		GGACTTCCTGCTCTTTCCCCC	0.388000													65	174					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23527796	23527796	+	Missense_Mutation	SNP	C	C	T			TCGA-IM-A3ED-01A-11D-A202-08	TCGA-IM-A3ED-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7d3599f-0218-4d1d-aed8-c45c188cd71d	ea16b689-e941-4ea0-ad31-9504e19ed28b	g.chr5:23527796C>T	uc003jgo.3	+	10	2781	c.2599C>T	c.(2599-2601)Cgg>Tgg	p.R867W		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	Homo sapiens PR domain containing 9 (PRDM9), mRNA.	867					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						GGAGTGTGGGCGGGGCTTTAG	0.562000										HNSCC(3;0.000094)			34	82					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61835632	61835632	+	Silent	SNP	C	C	T			TCGA-IM-A3ED-01A-11D-A202-08	TCGA-IM-A3ED-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7d3599f-0218-4d1d-aed8-c45c188cd71d	ea16b689-e941-4ea0-ad31-9504e19ed28b	g.chr10:61835632C>T	uc001jky.3	-	36	5345	c.5007G>A	c.(5005-5007)ccG>ccA	p.P1669P	ANK3_uc001jkw.3_Intron|ANK3_uc009xpa.3_Intron|ANK3_uc001jkx.3_Intron|ANK3_uc010qih.2_Intron|ANK3_uc001jkz.4_Intron|ANK3_uc001jkv.3_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	Homo sapiens ankyrin 3, node of Ranvier (ankyrin G) (ANK3), transcript variant 1, mRNA.	1669	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						AAGATATTAGCGGTGCTGCTG	0.393000													27	77					0	0	1	0	0
TMEM132A	54972	broad.mit.edu	37	11	60694815	60694815	+	Silent	SNP	C	C	A			TCGA-IM-A3ED-01A-11D-A202-08	TCGA-IM-A3ED-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7d3599f-0218-4d1d-aed8-c45c188cd71d	ea16b689-e941-4ea0-ad31-9504e19ed28b	g.chr11:60694815C>A	uc001nqi.3	+	1	433	c.240C>A	c.(238-240)acC>acA	p.T80T	TMEM132A_uc001nqj.3_Silent_p.T80T|TMEM132A_uc001nqk.3_Silent_p.T93T|TMEM132A_uc001nql.1_Silent_p.T93T	NM_017870	NP_060340	Q24JP5	T132A_HUMAN	Homo sapiens transmembrane protein 132A (TMEM132A), transcript variant 1, mRNA.	80						Golgi membrane|endoplasmic reticulum membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						GATCTGAGACCTTTCTGCTCC	0.647000													4	127					0	0	1	0	0
SLC7A11	23657	broad.mit.edu	37	4	139163108	139163108	+	Missense_Mutation	SNP	T	T	C			TCGA-IM-A3ED-01A-11D-A202-08	TCGA-IM-A3ED-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7d3599f-0218-4d1d-aed8-c45c188cd71d	ea16b689-e941-4ea0-ad31-9504e19ed28b	g.chr4:139163108T>C	uc021xrw.1	-	0	396	c.116A>G	c.(115-117)cAg>cGg	p.Q39R		NM_014331	NP_055146	Q9UPY5	XCT_HUMAN	Homo sapiens solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 (SLC7A11), mRNA.	39					blood coagulation|cellular nitrogen compound metabolic process|leukocyte migration|response to toxin	integral to membrane|plasma membrane	cystine:glutamate antiporter activity|protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(3)|liver(1)|lung(3)|prostate(1)|skin(2)	18	all_hematologic(180;0.166)				L-Cystine(DB00138)|L-Glutamic Acid(DB00142)|Sulfasalazine(DB00795)	CCTCTTCAGCTGCACTTTCTC	0.527000													3	91					0	0	1	0	0