Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PPM1D	8493	broad.mit.edu	37	17	58740503	58740503	+	Missense_Mutation	SNP	G	G	A			TCGA-FY-A3NN-01A-11D-A21A-08	TCGA-FY-A3NN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94685f1a-d017-41d1-8b00-1c24ac80ee18	2275d069-2d8f-4ea6-b1af-7ea5f185b985	g.chr17:58740503G>A	uc002iyt.2	+	5	1640	c.1408G>A	c.(1408-1410)Gat>Aat	p.D470N	PPM1D_uc010ddm.2_Non-coding_Transcript	NM_003620	NP_003611	O15297	PPM1D_HUMAN	Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent, 1D (PPM1D), mRNA.	470					negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	15	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			ACCCTCAAAAGATCCAGAACC	0.423000											OREG0031485	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	3	59					0	0	1	0	0
FGF3	2248	broad.mit.edu	37	11	69625427	69625427	+	Silent	SNP	G	G	A			TCGA-FY-A3NN-01A-11D-A21A-08	TCGA-FY-A3NN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94685f1a-d017-41d1-8b00-1c24ac80ee18	2275d069-2d8f-4ea6-b1af-7ea5f185b985	g.chr11:69625427G>A	uc001oph.3	-	2	857	c.366C>T	c.(364-366)caC>caT	p.H122H		NM_005247	NP_005238	P11487	FGF3_HUMAN	Homo sapiens fibroblast growth factor 3 (FGF3), mRNA.	122					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of cardiac muscle tissue development|positive regulation of cell division|positive regulation of cell proliferation	extracellular region	growth factor activity	p.H122Q(2)|p.H122N(1)		endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|urinary_tract(1)	13			LUSC - Lung squamous cell carcinoma(11;5.05e-15)|STAD - Stomach adenocarcinoma(18;0.0278)			AGCCCAGCTCGTGGATCCGCT	0.647000													7	174					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139658912	139658912	+	Missense_Mutation	SNP	G	G	A			TCGA-FY-A3NN-01A-11D-A21A-08	TCGA-FY-A3NN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94685f1a-d017-41d1-8b00-1c24ac80ee18	2275d069-2d8f-4ea6-b1af-7ea5f185b985	g.chr8:139658912G>A	uc003yvd.3	-	46	3908	c.3461C>T	c.(3460-3462)cCt>cTt	p.P1154L	COL22A1_uc011ljo.2_Missense_Mutation_p.P434L	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	Homo sapiens collagen, type XXII, alpha 1 (COL22A1), mRNA.	1154	Collagen-like 10.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity	p.P1154S(1)		breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TAGGCCTGGAGGCCCAGCCTC	0.493000										HNSCC(7;0.00092)			3	5					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-FY-A3NN-01A-11D-A21A-08	TCGA-FY-A3NN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94685f1a-d017-41d1-8b00-1c24ac80ee18	2275d069-2d8f-4ea6-b1af-7ea5f185b985	g.chr7:140453136A>T	uc003vwc.4	-	14	1860	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(41204)|p.V600K(615)|p.V600?(377)|p.V600R(99)|p.V600D(40)|p.V600_K601>E(30)|p.V600L(28)|p.V600A(24)|p.V600G(22)|p.V600M(22)|p.A598_T599insV(7)|p.T599_V600insT(7)|p.T599I(5)|p.V600Q(4)|p.T599_R603>I(4)|p.T599_V600insTT(3)|p.T599_V600insDFGLAT(2)|p.T599_V600>IAL(2)|p.V600_S605>EK(2)|p.T599T(2)|p.V600_S605>DV(2)|p.V600_S605>D(2)|p.V600_W604del(1)|p.V600V(1)|p.T599_V600insV(1)|p.V600>DLAT(1)|p.D594_T599del(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				28	60					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51111289	51111289	+	Silent	SNP	C	C	T			TCGA-FY-A3NN-01A-11D-A21A-08	TCGA-FY-A3NN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94685f1a-d017-41d1-8b00-1c24ac80ee18	2275d069-2d8f-4ea6-b1af-7ea5f185b985	g.chr7:51111289C>T	uc003tps.3	-	8	1553	c.1368G>A	c.(1366-1368)gcG>gcA	p.A456A	COBL_uc003tpr.4_Silent_p.A399A|COBL_uc011kcl.2_Silent_p.A399A|COBL_uc010kzc.3_Silent_p.A399A|COBL_uc003tpp.4_Silent_p.A185A|COBL_uc003tpq.4_Silent_p.A340A	NM_015198	NP_056013	O75128	COBL_HUMAN	Homo sapiens cordon-bleu homolog (mouse) (COBL), mRNA.	399										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					TGTCCTCCGACGCAAAACAGC	0.607000													5	93					0	0	1	0	0
TTC21B	79809	broad.mit.edu	37	2	166770121	166770121	+	Missense_Mutation	SNP	A	A	G			TCGA-FY-A3NN-01A-11D-A21A-08	TCGA-FY-A3NN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94685f1a-d017-41d1-8b00-1c24ac80ee18	2275d069-2d8f-4ea6-b1af-7ea5f185b985	g.chr2:166770121A>G	uc002udk.3	-	15	2307	c.2174T>C	c.(2173-2175)tTt>tCt	p.F725S		NM_024753	NP_079029	Q7Z4L5	TT21B_HUMAN	Homo sapiens tetratricopeptide repeat domain 21B (TTC21B), mRNA.	725						cilium axoneme|cytoplasm|cytoskeleton	binding			breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(9)|lung(28)|ovary(2)|pancreas(2)|skin(2)|urinary_tract(1)	58						AAGGAGAAGAAAAGACCGAGG	0.323000													18	51					0	0	1	0	0
ZNF493	284443	broad.mit.edu	37	19	21606565	21606565	+	Silent	SNP	A	A	G			TCGA-FY-A3NN-01A-11D-A21A-08	TCGA-FY-A3NN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94685f1a-d017-41d1-8b00-1c24ac80ee18	2275d069-2d8f-4ea6-b1af-7ea5f185b985	g.chr19:21606565A>G	uc002npw.3	+	3	1223	c.1104A>G	c.(1102-1104)aaA>aaG	p.K368K	ZNF493_uc002npx.3_Silent_p.K240K|ZNF493_uc002npy.3_Silent_p.K240K|ZNF493_uc021urq.1_Silent_p.K240K	NM_001076678	NP_787106	Q6ZR52	ZN493_HUMAN	Homo sapiens zinc finger protein 493 (ZNF493), transcript variant 3, mRNA.	240					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						CTACACATAAAAGAATTCATA	0.358000													3	73					0	0	1	0	0
TLR9	54106	broad.mit.edu	37	3	52266070	52266070	+	Silent	SNP	G	G	A			TCGA-FY-A3NN-01A-11D-A21A-08	TCGA-FY-A3NN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94685f1a-d017-41d1-8b00-1c24ac80ee18	2275d069-2d8f-4ea6-b1af-7ea5f185b985	g.chr3:52266070G>A	uc003ddd.3	-	2	323	c.172C>T	c.(172-174)Ctg>Ttg	p.L58L	TLR9_uc003ddb.3_5'Flank|TLR9_uc003ddc.1_5'Flank	NM_007284	NP_009215	Q9NR96	TLR9_HUMAN	Homo sapiens twinfilin, actin-binding protein, homolog 2 (Drosophila) (TWF2), mRNA.	0					I-kappaB phosphorylation|defense response to bacterium|fibroblast growth factor receptor signaling pathway|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of NF-kappaB transcription factor activity|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			endometrium(4)|large_intestine(11)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	AGCAGTGGCAGCACGGCCCTG	0.662000											OREG0015610	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	41					0	0	1	0	0
PTPRU	10076	broad.mit.edu	37	1	29586031	29586031	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FY-A3NN-01A-11D-A21A-08	TCGA-FY-A3NN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94685f1a-d017-41d1-8b00-1c24ac80ee18	2275d069-2d8f-4ea6-b1af-7ea5f185b985	g.chr1:29586031C>A	uc001bru.3	+	4	759	c.630C>A	c.(628-630)tgC>tgA	p.C210*	PTPRU_uc009vtq.3_Nonsense_Mutation_p.C210*|PTPRU_uc009vtr.3_Nonsense_Mutation_p.C210*|PTPRU_uc001brw.3_Nonsense_Mutation_p.C210*	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor type, U (PTPRU), transcript variant 3, mRNA.	210	Ig-like C2-type.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		CGTTCCAGTGCATGGCCGCGG	0.687000													3	58					0	0	1	0	0
ZNF623	9831	broad.mit.edu	37	8	144733418	144733418	+	Missense_Mutation	SNP	A	A	G			TCGA-FY-A3NN-01A-11D-A21A-08	TCGA-FY-A3NN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94685f1a-d017-41d1-8b00-1c24ac80ee18	2275d069-2d8f-4ea6-b1af-7ea5f185b985	g.chr8:144733418A>G	uc003yzd.2	+	0	1465	c.1376A>G	c.(1375-1377)tAt>tGt	p.Y459C	ZNF623_uc011lkp.1_Missense_Mutation_p.Y419C|ZNF623_uc003yzc.2_Missense_Mutation_p.Y419C	NM_014789	NP_055604	O75123	ZN623_HUMAN	Homo sapiens zinc finger protein 623 (ZNF623), transcript variant 1, mRNA.	459					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(6)|lung(11)|prostate(1)|stomach(1)|urinary_tract(3)	27	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GAAAAGCCCTATGTGTGCAGT	0.443000													34	50					0	0	1	0	0
CDH12	1010	broad.mit.edu	37	5	21817055	21817055	+	Splice_Site	SNP	T	T	C			TCGA-FY-A3NN-01A-11D-A21A-08	TCGA-FY-A3NN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94685f1a-d017-41d1-8b00-1c24ac80ee18	2275d069-2d8f-4ea6-b1af-7ea5f185b985	g.chr5:21817055T>C	uc010iuc.2	-	6	1460	c.1002_splice	c.e6+1	p.K334_splice	CDH12_uc011cno.1_Splice_Site_p.K294_splice|CDH12_uc003jgk.2_Splice_Site_p.K334_splice	NM_004061	NP_004052	P55289	CAD12_HUMAN	Homo sapiens cadherin 12, type 2 (N-cadherin 2) (CDH12), mRNA.	334	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						TCTATATACCTTTTTCAATTT	0.294000										HNSCC(59;0.17)			3	109					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31336828	31336828	+	Missense_Mutation	SNP	G	G	A			TCGA-FY-A3NN-01A-11D-A21A-08	TCGA-FY-A3NN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94685f1a-d017-41d1-8b00-1c24ac80ee18	2275d069-2d8f-4ea6-b1af-7ea5f185b985	g.chr16:31336828G>A	uc002ebr.3	+	20	2614	c.2516G>A	c.(2515-2517)cGc>cAc	p.R839H	ITGAM_uc002ebq.3_Missense_Mutation_p.R838H|ITGAM_uc010can.3_Missense_Mutation_p.R244H|ITGAM_uc002ebs.1_Missense_Mutation_p.R244H	NM_001145808	NP_001139280	P11215	ITAM_HUMAN	Homo sapiens integrin, alpha M (complement component 3 receptor 3 subunit) (ITGAM), transcript variant 1, mRNA.	838					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						CAGAACCAGCGCTCACAGCGA	0.602000													36	48					0	0	1	0	0
F10	2159	broad.mit.edu	37	13	113803259	113803259	+	Missense_Mutation	SNP	G	G	A			TCGA-FY-A3NN-01A-11D-A21A-08	TCGA-FY-A3NN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94685f1a-d017-41d1-8b00-1c24ac80ee18	2275d069-2d8f-4ea6-b1af-7ea5f185b985	g.chr13:113803259G>A	uc001vsx.3	+	7	952	c.895G>A	c.(895-897)Ggt>Agt	p.G299S	F10_uc001vsy.3_Silent_p.A295A	NM_000504	NP_000495	P00742	FA10_HUMAN	Homo sapiens coagulation factor X (F10), mRNA.	299	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	Golgi lumen|endoplasmic reticulum lumen|extracellular region	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			endometrium(2)|large_intestine(4)|lung(10)|pancreas(1)|stomach(1)	18	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGAGGAGGGCGGTGAGGCGGT	0.602000													6	321					0	0	1	0	0
MTHFD2L	441024	broad.mit.edu	37	4	75147202	75147202	+	Missense_Mutation	SNP	G	G	A			TCGA-FY-A3NN-01A-11D-A21A-08	TCGA-FY-A3NN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94685f1a-d017-41d1-8b00-1c24ac80ee18	2275d069-2d8f-4ea6-b1af-7ea5f185b985	g.chr4:75147202G>A	uc011cbk.2	+	6	893	c.866G>A	c.(865-867)gGt>gAt	p.G289D	MTHFD2L_uc003hhu.3_Non-coding_Transcript|BC016361_uc003hhv.1_Intron	NM_001144978	NP_001138450	Q9H903	MTD2L_HUMAN	Homo sapiens methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like (MTHFD2L), mRNA.	231					folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process		binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity			central_nervous_system(1)|endometrium(1)|lung(4)|ovary(2)	8			all cancers(17;0.0101)|Lung(101;0.196)			ATTGATGTGGGTATCAACTAT	0.368000													3	50					0	0	1	0	0
STON2	85439	broad.mit.edu	37	14	81743303	81743303	+	Silent	SNP	G	G	A			TCGA-FY-A3NN-01A-11D-A21A-08	TCGA-FY-A3NN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94685f1a-d017-41d1-8b00-1c24ac80ee18	2275d069-2d8f-4ea6-b1af-7ea5f185b985	g.chr14:81743303G>A	uc001xvk.1	-	5	2765	c.2352C>T	c.(2350-2352)taC>taT	p.Y784Y	STON2_uc010tvu.2_Silent_p.Y784Y|STON2_uc010tvt.2_Silent_p.Y581Y	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	Homo sapiens stonin 2 (STON2), transcript variant 1, mRNA.	784	MHD.				endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		AGGCATGCTCGTACTTGGCAG	0.493000													5	166					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52402841	52402841	+	Silent	SNP	G	G	A			TCGA-FY-A3NN-01A-11D-A21A-08	TCGA-FY-A3NN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94685f1a-d017-41d1-8b00-1c24ac80ee18	2275d069-2d8f-4ea6-b1af-7ea5f185b985	g.chr3:52402841G>A	uc011bef.2	+	36	6111	c.5850G>A	c.(5848-5850)ccG>ccA	p.P1950P		NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	Homo sapiens dynein, axonemal, heavy chain 1 (DNAH1), mRNA.	1950	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TCGATGGGCCGGTGGATGCCA	0.572000													4	237					0	0	1	0	0
MINOS1	440574	broad.mit.edu	37	1	19948613	19948613	+	Silent	SNP	A	A	T			TCGA-FY-A3NN-01A-11D-A21A-08	TCGA-FY-A3NN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94685f1a-d017-41d1-8b00-1c24ac80ee18	2275d069-2d8f-4ea6-b1af-7ea5f185b985	g.chr1:19948613A>T	uc021ohu.1	+	1	153	c.84A>T	c.(82-84)ggA>ggT	p.G28G	MINOS1_uc001bch.2_Non-coding_Transcript|MINOS1_uc001bci.2_Silent_p.G28G|MINOS1_uc021oht.1_Intron|MINOS1_uc021ohv.1_Non-coding_Transcript|NBL1_uc021ohw.1_Intron|NBL1_uc009vpl.2_Intron	NM_001204083	NP_001191012	Q5TGZ0	CA151_HUMAN	Homo sapiens mitochondrial inner membrane organizing system 1 (MINOS1), nuclear gene encoding mitochondrial protein, transcript variant 5, mRNA.	28						integral to membrane|mitochondrion											TTGGATTAGGAATTGTTTTCT	0.343000													8	36					0	0	1	0	0
NAPSB	256236	broad.mit.edu	37	19	50838162	50838162	+	Missense_Mutation	SNP	G	G	A			TCGA-FY-A3NN-01A-11D-A21A-08	TCGA-FY-A3NN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94685f1a-d017-41d1-8b00-1c24ac80ee18	2275d069-2d8f-4ea6-b1af-7ea5f185b985	g.chr19:50838162G>A	uc002prw.3	-	6	853	c.77C>T	c.(76-78)cCt>cTt	p.P26L	NR1H2_uc002prv.4_Intron					Homo sapiens napsin B aspartic peptidase pseudogene (NAPSB), non-coding RNA.											central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(1)	4						TACGATGACAGGTGTGCCTGT	0.617000													3	42					0	0	1	0	0
SLC27A4	10999	broad.mit.edu	37	9	131112801	131112801	+	Missense_Mutation	SNP	G	G	A			TCGA-FY-A3NN-01A-11D-A21A-08	TCGA-FY-A3NN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94685f1a-d017-41d1-8b00-1c24ac80ee18	2275d069-2d8f-4ea6-b1af-7ea5f185b985	g.chr9:131112801G>A	uc004but.3	+	5	1109	c.824G>A	c.(823-825)cGc>cAc	p.R275H	SLC27A4_uc004buu.3_Intron	NM_005094	NP_005085	Q6P1M0	S27A4_HUMAN	Homo sapiens solute carrier family 27 (fatty acid transporter), member 4 (SLC27A4), mRNA.	275					long-chain fatty acid transport|transmembrane transport	integral to membrane	fatty acid transporter activity|nucleotide binding|protein binding			autonomic_ganglia(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(2)	13						TATGGATTCCGCATGCGGCCC	0.607000													3	36					0	0	1	0	0
KRT33A	3883	broad.mit.edu	37	17	39504836	39504836	+	Missense_Mutation	SNP	G	G	A			TCGA-FY-A3NN-01A-11D-A21A-08	TCGA-FY-A3NN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94685f1a-d017-41d1-8b00-1c24ac80ee18	2275d069-2d8f-4ea6-b1af-7ea5f185b985	g.chr17:39504836G>A	uc002hwk.1	-	2	524	c.487C>T	c.(487-489)Cgc>Tgc	p.R163C		NM_004138	NP_004129	O76009	KT33A_HUMAN	Homo sapiens keratin 33A (KRT33A), mRNA.	163	Coil 1B.|Rod.					intermediate filament	protein binding|structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	21		Breast(137;0.000496)				AGGATCCTGCGCAGGCCATTG	0.607000													4	170					0	0	1	0	0