Hugo_Symbol Entrez_Gene_Id Center NCBI_Build Chromosome Start_position End_position Strand Variant_Classification Variant_Type Reference_Allele Tumor_Seq_Allele1 Tumor_Seq_Allele2 dbSNP_RS dbSNP_Val_Status Tumor_Sample_Barcode Matched_Norm_Sample_Barcode Match_Norm_Seq_Allele1 Match_Norm_Seq_Allele2 Tumor_Validation_Allele1 Tumor_Validation_Allele2 Match_Norm_Validation_Allele1 Match_Norm_Validation_Allele2 Verification_Status Validation_Status Mutation_Status Sequencing_Phase Sequence_Source Validation_Method Score BAM_file Sequencer Tumor_Sample_UUID Matched_Norm_Sample_UUID Genome_Change Annotation_Transcript Transcript_Strand Transcript_Exon Transcript_Position cDNA_Change Codon_Change Protein_Change Other_Transcripts Refseq_mRNA_Id Refseq_prot_Id SwissProt_acc_Id SwissProt_entry_Id Description UniProt_AApos UniProt_Region UniProt_Site UniProt_Natural_Variations UniProt_Experimental_Info GO_Biological_Process GO_Cellular_Component GO_Molecular_Function COSMIC_overlapping_mutations COSMIC_fusion_genes COSMIC_tissue_types_affected COSMIC_total_alterations_in_gene Tumorscape_Amplification_Peaks Tumorscape_Deletion_Peaks TCGAscape_Amplification_Peaks TCGAscape_Deletion_Peaks DrugBank ref_context gc_content CCLE_ONCOMAP_overlapping_mutations CCLE_ONCOMAP_total_mutations_in_gene CGC_Mutation_Type CGC_Translocation_Partner CGC_Tumor_Types_Somatic CGC_Tumor_Types_Germline CGC_Other_Diseases DNARepairGenes_Role FamilialCancerDatabase_Syndromes MUTSIG_Published_Results OREGANNO_ID OREGANNO_Values t_alt_count t_ref_count validation_alt_allele validation_method validation_status validation_tumor_sample pox qox pox_cutoff isArtifactMode oxoGCut CITED2 10370 broad.mit.edu 37 6 139694455 139694455 + Silent SNP G G T TCGA-ET-A3DQ-01A-11D-A19J-08 TCGA-ET-A3DQ-10A-01D-A19M-08 Untested Somatic Phase_I WXS none Illumina GAIIx d911ad12-c0cf-485b-acb4-13ce9e0385ea c77ff260-24f6-413f-9bed-4f2975f54f41 g.chr6:139694455G>T uc021zfz.1 - 1 717 c.627C>A c.(625-627)ccC>ccA p.P209P CITED2_uc021zga.1_Silent_p.P209P|CITED2_uc003qip.1_Silent_p.P209P|CITED2_uc021zgb.1_Silent_p.P209P NM_001168389 NP_006070 Q99967 CITE2_HUMAN Homo sapiens Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 (CITED2), transcript variant 3, mRNA. 209 adrenal cortex formation|anti-apoptosis|cell proliferation|determination of left/right symmetry|heart development|liver development|negative regulation of cell migration|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell cycle|positive regulation of cell-cell adhesion|positive regulation of male gonad development|positive regulation of peroxisome proliferator activated receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of organ formation|response to estrogen stimulus|response to fluid shear stress|response to hypoxia|sex determination cytoplasm|nuclear chromatin|nucleus LBD domain binding|chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity large_intestine(1)|lung(4) 5 Breast(32;0.226) GBM - Glioblastoma multiforme(68;0.000171)|OV - Ovarian serous cystadenocarcinoma(155;0.00134) GCATTGCAGCGGGGACGTGGG 0.647000 12 84 0 0 1 0 0 CASP7 840 broad.mit.edu 37 10 115481474 115481474 + Silent SNP G G T TCGA-ET-A3DQ-01A-11D-A19J-08 TCGA-ET-A3DQ-10A-01D-A19M-08 Untested Somatic Phase_I WXS none Illumina GAIIx d911ad12-c0cf-485b-acb4-13ce9e0385ea c77ff260-24f6-413f-9bed-4f2975f54f41 g.chr10:115481474G>T uc010qsa.2 + 3 655 c.567G>T c.(565-567)ctG>ctT p.L189L CASP7_uc001lam.3_Silent_p.L104L|CASP7_uc001lan.3_Silent_p.L104L|CASP7_uc001lao.3_Silent_p.L137L|CASP7_uc001lap.3_Silent_p.L104L|CASP7_uc001laq.3_Silent_p.L104L|CASP7_uc010qsb.2_Silent_p.L79L P55210 CASP7_HUMAN Homo sapiens caspase 7, apoptosis-related cysteine peptidase (CASP7), transcript variant alpha, mRNA. 104 activation of caspase activity by cytochrome c|cellular component disassembly involved in apoptosis|induction of apoptosis by intracellular signals|proteolysis cytosol|endoplasmic reticulum membrane|mitochondrial membrane|nucleoplasm cysteine-type endopeptidase activity|protein binding kidney(1)|large_intestine(1)|lung(5)|ovary(1) 8 Colorectal(252;0.0946)|Breast(234;0.188) Epithelial(162;0.012)|all cancers(201;0.014) TCCGAAGCCTGGGTTTTGACG 0.498000 21 115 0 0 1 0 0 KLHL14 57565 broad.mit.edu 37 18 30350455 30350455 + Missense_Mutation SNP C C A TCGA-ET-A3DQ-01A-11D-A19J-08 TCGA-ET-A3DQ-10A-01D-A19M-08 Untested Somatic Phase_I WXS none Illumina GAIIx d911ad12-c0cf-485b-acb4-13ce9e0385ea c77ff260-24f6-413f-9bed-4f2975f54f41 g.chr18:30350455C>A uc002kxm.1 - 1 488 c.100G>T c.(100-102)Gac>Tac p.D34Y NM_020805 NP_065856 Q9P2G3 KLH14_HUMAN Homo sapiens kelch-like 14 (Drosophila) (KLHL14), mRNA. 34 BTB. cytosol|endoplasmic reticulum membrane breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2) 31 AGGGTCACGTCGCAAAACAGC 0.642000 13 47 0 0 1 0 0 PDCD6 10016 broad.mit.edu 37 5 272944 272944 + Missense_Mutation SNP T T C TCGA-ET-A3DQ-01A-11D-A19J-08 TCGA-ET-A3DQ-10A-01D-A19M-08 Untested Somatic Phase_I WXS none Illumina GAIIx d911ad12-c0cf-485b-acb4-13ce9e0385ea c77ff260-24f6-413f-9bed-4f2975f54f41 g.chr5:272944T>C uc010isw.1 + 1 320 c.316T>C c.(316-318)Ttc>Ctc p.F106L PDCD6_uc003jas.3_Intron|PDCD6_uc003jat.1_Intron|PDCD6_uc003jau.1_Intron O75340 PDCD6_HUMAN Homo sapiens programmed cell death 6 (PDCD6), mRNA. 0 EF-hand 3. induction of apoptosis by extracellular signals|response to calcium ion endoplasmic reticulum membrane|nuclear membrane binding, bridging|calcium ion binding|calcium-dependent protein binding breast(2)|endometrium(1)|large_intestine(4)|lung(1) 8 Epithelial(17;0.00193)|OV - Ovarian serous cystadenocarcinoma(19;0.00489)|all cancers(22;0.00511)|Lung(60;0.113) GCCTGCCCTGTTCACAGTGGA 0.483000 6 13 0 0 1 0 0 ZMYND15 84225 broad.mit.edu 37 17 4643964 4643964 + Silent SNP C C A TCGA-ET-A3DQ-01A-11D-A19J-08 TCGA-ET-A3DQ-10A-01D-A19M-08 Untested Somatic Phase_I WXS none Illumina GAIIx d911ad12-c0cf-485b-acb4-13ce9e0385ea c77ff260-24f6-413f-9bed-4f2975f54f41 g.chr17:4643964C>A uc002fyu.2 + 0 151 c.121C>A c.(121-123)Cgg>Agg p.R41R CXCL16_uc002fyr.4_5'Flank|CXCL16_uc002fys.4_5'Flank|ZMYND15_uc002fyv.2_Silent_p.R41R|ZMYND15_uc002fyt.2_Silent_p.R41R NM_001136046 NP_001129518 Q9H091 ZMY15_HUMAN Homo sapiens zinc finger, MYND-type containing 15 (ZMYND15), transcript variant 1, mRNA. 41 zinc ion binding endometrium(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2) 18 GGGCCGCTGCCGGCAGCTGGA 0.612000 3 39 0 0 1 0 0