Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TNKS1BP1	85456	broad.mit.edu	37	11	57075943	57075943	+	Silent	SNP	G	G	A			TCGA-EM-A3AO-01A-11D-A202-08	TCGA-EM-A3AO-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fcc88f7-6d11-4c1f-8267-639d9460860b	a6b37086-7f13-4a9d-bfb8-bdd5e53eb4bb	g.chr11:57075943G>A	uc001njr.3	-	4	4554	c.4242C>T	c.(4240-4242)taC>taT	p.Y1414Y	TNKS1BP1_uc001njs.3_Silent_p.Y1414Y|TNKS1BP1_uc009ymd.1_Silent_p.Y865Y	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	Homo sapiens tankyrase 1 binding protein 1, 182kDa (TNKS1BP1), mRNA.	1414	Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				AAGACGAGGAGTAATCTTCAC	0.602000													130	287					0	0	1	0	0
KCNG2	26251	broad.mit.edu	37	18	77659600	77659600	+	Silent	SNP	G	G	A			TCGA-EM-A3AO-01A-11D-A202-08	TCGA-EM-A3AO-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fcc88f7-6d11-4c1f-8267-639d9460860b	a6b37086-7f13-4a9d-bfb8-bdd5e53eb4bb	g.chr18:77659600G>A	uc010xfl.2	+	1	1185	c.1185G>A	c.(1183-1185)ctG>ctA	p.L395L		NM_012283	NP_036415	Q9UJ96	KCNG2_HUMAN	Homo sapiens potassium voltage-gated channel, subfamily G, member 2 (KCNG2), mRNA.	395					energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity			breast(2)|endometrium(4)|lung(7)|skin(1)|upper_aerodigestive_tract(4)	18		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		GCGGCATCCTGCTCATGGCCT	0.692000													7	73					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23866411	23866411	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A3AO-01A-11D-A202-08	TCGA-EM-A3AO-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fcc88f7-6d11-4c1f-8267-639d9460860b	a6b37086-7f13-4a9d-bfb8-bdd5e53eb4bb	g.chr14:23866411C>T	uc001wjv.3	-	16	2089	c.2018G>A	c.(2017-2019)cGt>cAt	p.R673H		NM_002471	NP_002462	P13533	MYH6_HUMAN	Homo sapiens myosin, heavy chain 6, cardiac muscle, alpha (MYH6), mRNA.	673	Actin-binding.|Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	ATP binding|actin binding|actin-dependent ATPase activity|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle	p.R673H(2)		breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GATGATGCAACGCACAAAGTG	0.542000													64	138					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1497638	1497638	+	Missense_Mutation	SNP	T	T	C			TCGA-EM-A3AO-01A-11D-A202-08	TCGA-EM-A3AO-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fcc88f7-6d11-4c1f-8267-639d9460860b	a6b37086-7f13-4a9d-bfb8-bdd5e53eb4bb	g.chr8:1497638T>C	uc003wpl.3	+	1	876	c.779T>C	c.(778-780)cTc>cCc	p.L260P	DLGAP2_uc003wpm.3_Missense_Mutation_p.L260P	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	Homo sapiens discs, large (Drosophila) homolog-associated protein 2 (DLGAP2), mRNA.	339					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		GACCTGTCCCTCAAGACCTCC	0.667000													3	127					0	0	1	0	0
PDE5A	8654	broad.mit.edu	37	4	120463753	120463753	+	Missense_Mutation	SNP	G	G	C			TCGA-EM-A3AO-01A-11D-A202-08	TCGA-EM-A3AO-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fcc88f7-6d11-4c1f-8267-639d9460860b	a6b37086-7f13-4a9d-bfb8-bdd5e53eb4bb	g.chr4:120463753G>C	uc003idh.3	-	9	1588	c.1433C>G	c.(1432-1434)aCt>aGt	p.T478S	PDE5A_uc003idf.3_Missense_Mutation_p.T436S|PDE5A_uc003idg.3_Missense_Mutation_p.T426S|AF085995_uc003idi.4_Intron	NM_001083	NP_246273	O76074	PDE5A_HUMAN	Homo sapiens phosphodiesterase 5A, cGMP-specific (PDE5A), transcript variant 1, mRNA.	478	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding			breast(4)|endometrium(2)|kidney(3)|large_intestine(8)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	27					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	AACCTTGCCAGTATTCTCCTC	0.388000													33	56					0	0	1	0	0
LRRN4	164312	broad.mit.edu	37	20	6022440	6022440	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A3AO-01A-11D-A202-08	TCGA-EM-A3AO-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fcc88f7-6d11-4c1f-8267-639d9460860b	a6b37086-7f13-4a9d-bfb8-bdd5e53eb4bb	g.chr20:6022440C>T	uc002wmo.2	-	4	1675	c.1451G>A	c.(1450-1452)gGc>gAc	p.G484D		NM_152611	NP_689824	Q8WUT4	LRRN4_HUMAN	Homo sapiens leucine rich repeat neuronal 4 (LRRN4), mRNA.	484						integral to membrane				breast(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	27						AGGGAAGGGGCCCAGGAGCTT	0.657000													45	115					0	0	1	0	0
NEK8	284086	broad.mit.edu	37	17	27068491	27068491	+	Missense_Mutation	SNP	A	A	G			TCGA-EM-A3AO-01A-11D-A202-08	TCGA-EM-A3AO-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fcc88f7-6d11-4c1f-8267-639d9460860b	a6b37086-7f13-4a9d-bfb8-bdd5e53eb4bb	g.chr17:27068491A>G	uc002hcp.3	+	13	1952	c.1952A>G	c.(1951-1953)gAt>gGt	p.D651G	TRAF4_uc002hcq.1_5'Flank|TRAF4_uc002hcs.3_5'Flank	NM_178170	NP_835464	Q86SG6	NEK8_HUMAN	Homo sapiens NIMA (never in mitosis gene a)- related kinase 8 (NEK8), mRNA.	651						cytoplasm|primary cilium	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	Lung NSC(42;0.0158)					AGGGATGAGGATGCCGGACTC	0.592000													26	52					0	0	1	0	0
SLC9B2	133308	broad.mit.edu	37	4	103988620	103988620	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EM-A3AO-01A-11D-A202-08	TCGA-EM-A3AO-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fcc88f7-6d11-4c1f-8267-639d9460860b	a6b37086-7f13-4a9d-bfb8-bdd5e53eb4bb	g.chr4:103988620G>A	uc003hwx.4	-	1	960	c.88C>T	c.(88-90)Cag>Tag	p.Q30*	SLC9B2_uc003hwy.3_Nonsense_Mutation_p.Q30*|SLC9B2_uc011cew.2_Nonsense_Mutation_p.Q30*|SLC9B2_uc011cex.1_Nonsense_Mutation_p.Q30*|SLC9B2_uc011cey.2_Nonsense_Mutation_p.Q30*	NM_178833	NP_849155	Q86UD5	NHDC2_HUMAN	Homo sapiens solute carrier family 9, subfamily B (cation proton antiporter 2), member 2 (SLC9B2), nuclear gene encoding mitochondrial protein, mRNA.	30					sodium ion transport	integral to membrane|mitochondrial membrane	solute:hydrogen antiporter activity										AGATTTACCTGTGCTTCTTGA	0.368000													5	85					0	0	1	0	0
BCAS3	54828	broad.mit.edu	37	17	59024649	59024649	+	Missense_Mutation	SNP	G	G	C			TCGA-EM-A3AO-01A-11D-A202-08	TCGA-EM-A3AO-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fcc88f7-6d11-4c1f-8267-639d9460860b	a6b37086-7f13-4a9d-bfb8-bdd5e53eb4bb	g.chr17:59024649G>C	uc002iyv.4	+	13	1266	c.1157G>C	c.(1156-1158)tGg>tCg	p.W386S	BCAS3_uc010wow.1_Missense_Mutation_p.W173S|BCAS3_uc002iyu.4_Missense_Mutation_p.W386S|BCAS3_uc002iyw.4_Missense_Mutation_p.W382S|BCAS3_uc002iyx.1_Missense_Mutation_p.W201S|BCAS3_uc002iyy.4_Missense_Mutation_p.W157S	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	Homo sapiens breast carcinoma amplified sequence 3 (BCAS3), transcript variant 1, mRNA.	386						nucleus				NS(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(24)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			ACTCATCCTTGGTCCTCATCA	0.413000													7	209					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133883736	133883736	+	Missense_Mutation	SNP	T	T	G			TCGA-EM-A3AO-01A-11D-A202-08	TCGA-EM-A3AO-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fcc88f7-6d11-4c1f-8267-639d9460860b	a6b37086-7f13-4a9d-bfb8-bdd5e53eb4bb	g.chr8:133883736T>G	uc003ytw.3	+	3	459	c.418T>G	c.(418-420)Tgt>Ggt	p.C140G		NM_003235	NP_003226	P01266	THYG_HUMAN	Homo sapiens thyroglobulin (TG), mRNA.	140	Thyroglobulin type-1 2.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CCAGTGCTGGTGTGTGGACGC	0.597000													27	50					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30495432	30495432	+	Splice_Site	DEL	A	A	-			TCGA-EM-A3AO-01A-11D-A202-08	TCGA-EM-A3AO-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fcc88f7-6d11-4c1f-8267-639d9460860b	a6b37086-7f13-4a9d-bfb8-bdd5e53eb4bb	g.chr16:30495432delA	uc002dyi.4	+	9	1032	c.856_splice	c.e9-2	p.I286_splice	ITGAL_uc010veu.1_Splice_Site|ITGAL_uc002dyj.4_Splice_Site_p.I203_splice|ITGAL_uc010vev.2_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	Homo sapiens integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) (ITGAL), transcript variant 1, mRNA.	286	VWFA.				T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	ACTCCCTCACAGATTGGAAAG	0.488													82	147	---	---	---	---