Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PLD2	5338	broad.mit.edu	37	17	4719165	4719165	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr17:4719165G>A	uc002fzc.3	+	13	1517	c.1391G>A	c.(1390-1392)cGc>cAc	p.R464H	PLD2_uc010vsj.2_Missense_Mutation_p.R321H|PLD2_uc002fzd.3_Missense_Mutation_p.R464H	NM_002663	NP_002654	O14939	PLD2_HUMAN	Homo sapiens phospholipase D2 (PLD2), transcript variant 1, mRNA.	464	Catalytic.|PLD phosphodiesterase 1.				cell communication|cytoskeleton organization|small GTPase mediated signal transduction		NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)	31					Choline(DB00122)	GCCTATGGCCGCTGGGATGAC	0.597000											OREG0024105	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	140					0	0	1	0	0
LAMP3	27074	broad.mit.edu	37	3	182841901	182841901	+	Missense_Mutation	SNP	T	T	A			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr3:182841901T>A	uc003flh.4	-	5	1443	c.1219A>T	c.(1219-1221)Agg>Tgg	p.R407W		NM_014398	NP_055213	Q9UQV4	LAMP3_HUMAN	Homo sapiens lysosomal-associated membrane protein 3 (LAMP3), mRNA.	407					cell proliferation	integral to membrane|lysosomal membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(9)|ovary(2)|prostate(2)	28	all_cancers(143;9.14e-14)|Ovarian(172;0.0355)		all cancers(12;2.91e-44)|Epithelial(37;5.52e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;4.16e-21)			GATTGACACCTTAGGCGGATT	0.458000													5	145					0	0	1	0	0
RPL12	6136	broad.mit.edu	37	9	130213590	130213590	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr9:130213590G>A	uc004bqy.2	-	0	122	c.7C>T	c.(7-9)Ccg>Tcg	p.P3S	RPL12_uc004bqz.2_Missense_Mutation_p.P3S|SNORA65_uc004bra.1_5'Flank|LRSAM1_uc004brb.2_5'Flank|LRSAM1_uc010mxk.2_5'Flank|LRSAM1_uc004brc.2_5'Flank|LRSAM1_uc004brd.2_5'Flank	NM_000976	NP_000967	P30050	RL12_HUMAN	Homo sapiens ribosomal protein L12 (RPL12), mRNA.	3					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome	p.P3P(1)		haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|prostate(1)	4						TCGAACTTCGGCGGCATGGTG	0.657000													6	67					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	70034893	70034893	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr6:70034893C>T	uc010kak.3	+	19	3220	c.2944C>T	c.(2944-2946)Cgc>Tgc	p.R982C	BAI3_uc003pev.4_Missense_Mutation_p.R982C|BAI3_uc011dxx.2_Missense_Mutation_p.R188C	NM_001704	NP_001695	O60242	BAI3_HUMAN	Homo sapiens brain-specific angiogenesis inhibitor 3 (BAI3), mRNA.	982					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				TATAAGAAAACGCTTTTTGTG	0.403000													12	134					0	0	1	0	0
GAS1	2619	broad.mit.edu	37	9	89560958	89560958	+	Missense_Mutation	SNP	G	G	C			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr9:89560958G>C	uc004aox.4	-	0	1147	c.737C>G	c.(736-738)gCc>gGc	p.A246G	BC036850_uc004aoy.3_5'Flank	NM_002048	NP_002039	P54826	GAS1_HUMAN	Homo sapiens growth arrest-specific 1 (GAS1), mRNA.	246					cell cycle arrest|negative regulation of S phase of mitotic cell cycle	anchored to plasma membrane				kidney(1)|lung(2)|skin(1)	4						GCCCAGCTCGGCGCCGAAGCA	0.701000													4	28					0	0	1	0	0
MRPS30	10884	broad.mit.edu	37	5	44809124	44809124	+	Silent	SNP	C	C	T			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr5:44809124C>T	uc003joh.3	+	0	98	c.60C>T	c.(58-60)acC>acT	p.T20T	MRPS30_uc003joi.1_5'Flank	NM_016640	NP_057724	Q9NP92	RT30_HUMAN	Homo sapiens mitochondrial ribosomal protein S30 (MRPS30), nuclear gene encoding mitochondrial protein, mRNA.	20					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome			central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(2)|lung(11)|prostate(1)	20	Lung NSC(6;8.08e-07)					CATTGCACACCGCGGCTAATG	0.647000													8	9					0	0	1	0	0
MRPS23	51649	broad.mit.edu	37	17	55918341	55918341	+	Silent	SNP	C	C	G			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr17:55918341C>G	uc002ivc.3	-	3	428	c.366G>C	c.(364-366)ggG>ggC	p.G122G		NM_016070	NP_057154	Q9Y3D9	RT23_HUMAN	Homo sapiens mitochondrial ribosomal protein S23 (MRPS23), nuclear gene encoding mitochondrial protein, mRNA.	122					translation	intermediate filament cytoskeleton|mitochondrion|nuclear membrane|ribosome	structural constituent of ribosome	p.G122R(1)		endometrium(2)|large_intestine(1)|lung(2)	5	Breast(9;8.75e-08)					ATAAAGCCTTCCCTGTTTCCA	0.398000													3	144					0	0	1	0	0
ENPP2	5168	broad.mit.edu	37	8	120606083	120606083	+	Missense_Mutation	SNP	C	C	G			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr8:120606083C>G	uc003yos.2	-	12	1232	c.1146G>C	c.(1144-1146)agG>agC	p.R382S	ENPP2_uc003yor.2_5'Flank|ENPP2_uc010mdd.2_Missense_Mutation_p.R330S|ENPP2_uc003yot.2_Missense_Mutation_p.R330S	NM_006209	NP_006200	Q13822	ENPP2_HUMAN	Homo sapiens ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), transcript variant 1, mRNA.	330					G-protein coupled receptor protein signaling pathway|cellular component movement|chemotaxis|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(30)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)	69	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TGTCGATTTCCCTCAGAGGAT	0.423000													11	335					0	0	1	0	0
CDS2	8760	broad.mit.edu	37	20	5169753	5169753	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr20:5169753C>T	uc002wls.3	+	10	1354	c.1022C>T	c.(1021-1023)gCt>gTt	p.A341V	CDS2_uc002wlw.3_Missense_Mutation_p.A221V|CDS2_uc002wlv.3_Missense_Mutation_p.A243V|CDS2_uc010zqv.2_Missense_Mutation_p.A111V	NM_003818	NP_003809	O95674	CDS2_HUMAN	Homo sapiens CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 (CDS2), mRNA.	341					phospholipid biosynthetic process	integral to membrane|mitochondrial inner membrane	phosphatidate cytidylyltransferase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|prostate(1)|stomach(1)	14						CACAGCATCGCTCTCTCCACC	0.458000													46	75					0	0	1	0	0
OR2J2	26707	broad.mit.edu	37	6	29141930	29141930	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr6:29141930G>A	uc011dlm.2	+	0	620	c.518G>A	c.(517-519)cGc>cAc	p.R173H		NM_030905	NP_112167	O76002	OR2J2_HUMAN	Homo sapiens olfactory receptor, family 2, subfamily J, member 2 (OR2J2), mRNA.	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						TGTGGACATCGCCTAGTGGAT	0.468000													44	171					0	0	1	0	0
DTNA	1837	broad.mit.edu	37	18	32374191	32374191	+	Silent	SNP	C	C	T			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr18:32374191C>T	uc010dmn.1	+	2	340	c.339C>T	c.(337-339)aaC>aaT	p.N113N	DTNA_uc002kxu.2_Silent_p.N113N|DTNA_uc010xbx.2_Silent_p.N113N|DTNA_uc002kxv.4_Silent_p.N113N|DTNA_uc002kxw.2_Silent_p.N113N|DTNA_uc002kxx.2_Silent_p.N113N|DTNA_uc002kxz.2_Silent_p.N113N|DTNA_uc002kxy.2_Silent_p.N113N|DTNA_uc010dmj.3_Silent_p.N113N|DTNA_uc002kyb.4_Silent_p.N113N|DTNA_uc010dml.3_Silent_p.N113N|DTNA_uc010dmm.3_Silent_p.N113N	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	Homo sapiens dystrobrevin, alpha (DTNA), transcript variant 1, mRNA.	113	Interaction with MAGEE1 (By similarity).				neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(2)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	29						TCCTCCTTAACTTCCTGCTTG	0.473000													13	95					0	0	1	0	0
NAIP	4671	broad.mit.edu	37	5	70308276	70308276	+	Missense_Mutation	SNP	T	T	C			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr5:70308276T>C	uc003kar.1	-	3	1185	c.467A>G	c.(466-468)tAc>tGc	p.Y156C	NAIP_uc003kat.1_Intron|NAIP_uc011crs.1_Missense_Mutation_p.Y156C|NAIP_uc003kas.1_Intron	NM_004536	NP_004527	Q13075	BIRC1_HUMAN	Homo sapiens NLR family, apoptosis inhibitory protein (NAIP), transcript variant 1, mRNA.	156					anti-apoptosis|apoptosis|nervous system development	basolateral plasma membrane|cytoplasm	caspase inhibitor activity|metal ion binding|nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(1)	1		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		CTCTTCTTGGTACCTCATTTT	0.468000													3	124					0	0	1	0	0
PRKD3	23683	broad.mit.edu	37	2	37496767	37496767	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr2:37496767C>T	uc002rqd.3	-	11	2323	c.1768G>A	c.(1768-1770)Gtt>Att	p.V590I	PRKD3_uc002rqe.1_Missense_Mutation_p.V190I|PRKD3_uc002rqf.1_Missense_Mutation_p.V590I	NM_005813	NP_005804	O94806	KPCD3_HUMAN	Homo sapiens protein kinase D3 (PRKD3), mRNA.	590	Protein kinase.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			breast(3)|central_nervous_system(2)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.21)				CCTCCATAAACGATGCCAAAC	0.368000													3	56					0	0	1	0	0
ADSSL1	122622	broad.mit.edu	37	14	105212622	105212622	+	Silent	SNP	T	T	G			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr14:105212622T>G	uc001ype.3	+	11	1352	c.1350T>G	c.(1348-1350)ccT>ccG	p.P450P	ADSSL1_uc001ypd.3_Silent_p.P407P|ADSSL1_uc001ypf.3_Non-coding_Transcript	NM_199165	NP_954634	Q8N142	PURA1_HUMAN	Homo sapiens adenylosuccinate synthase like 1 (ADSSL1), transcript variant 1, mRNA.	407					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	GTP binding|adenylosuccinate synthase activity|magnesium ion binding|phosphate binding			central_nervous_system(1)|cervix(1)|kidney(1)|lung(5)|ovary(2)|prostate(1)	11		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	AAACGCTGCCTGGGTGGAAAG	0.587000													7	79					0	0	1	0	0
NKD1	85407	broad.mit.edu	37	16	50666208	50666208	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr16:50666208C>T	uc002egg.2	+	8	936	c.712C>T	c.(712-714)Cgc>Tgc	p.R238C		NM_033119	NP_149110	Q969G9	NKD1_HUMAN	Homo sapiens naked cuticle homolog 1 (Drosophila) (NKD1), mRNA.	238					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|prostate(1)|urinary_tract(2)	23		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		GGGTGACAGCCGCCTGGAGCA	0.562000													27	37					0	0	1	0	0
CSF2RB	1439	broad.mit.edu	37	22	37325500	37325500	+	Missense_Mutation	SNP	C	C	A			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr22:37325500C>A	uc003aqc.4	+	3	620	c.448C>A	c.(448-450)Ctg>Atg	p.L150M	CSF2RB_uc003aqa.4_Missense_Mutation_p.L150M	NM_000395	NP_000386	P32927	IL3RB_HUMAN	Homo sapiens colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (CSF2RB), mRNA.	150	Fibronectin type-III 1.				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	CCACTTCCTGCTGACCTGGAG	0.627000													4	169					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53084925	53084925	+	Nonsense_Mutation	SNP	C	C	A			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr8:53084925C>A	uc003xqz.2	-	4	652	c.496G>T	c.(496-498)Gag>Tag	p.E166*	ST18_uc011ldq.1_5'UTR|ST18_uc011ldr.1_Nonsense_Mutation_p.E131*|ST18_uc011lds.1_Nonsense_Mutation_p.E71*|ST18_uc003xra.2_Nonsense_Mutation_p.E166*|ST18_uc003xrb.2_Nonsense_Mutation_p.E166*	NM_014682	NP_055497	O60284	ST18_HUMAN	Homo sapiens suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein) (ST18), mRNA.	166						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				AGAAAGCACTCGTCTGCTTCA	0.398000													3	87					0	0	1	0	0
DCT	1638	broad.mit.edu	37	13	95121126	95121126	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr13:95121126C>T	uc010afh.3	-	1	896	c.469G>A	c.(469-471)Gtg>Atg	p.V157M	DCT_uc001vlv.4_Missense_Mutation_p.V157M	NM_001129889	NP_001123361	P40126	TYRP2_HUMAN	Homo sapiens dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) (DCT), transcript variant 2, mRNA.	157					epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	50	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		GTGGTGATCACGTAGTCGGGG	0.517000													96	180					0	0	1	0	0
CNGA2	1260	broad.mit.edu	37	X	150911807	150911807	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chrX:150911807C>T	uc004fey.1	+	6	1056	c.832C>T	c.(832-834)Ctt>Ttt	p.L278F		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	Homo sapiens cyclic nucleotide gated channel alpha 2 (CNGA2), mRNA.	278					response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(4)|endometrium(4)|large_intestine(5)|lung(34)|prostate(2)	49	Acute lymphoblastic leukemia(192;6.56e-05)					CATCAGCAACCTTGTCCTCTA	0.512000													4	222					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107869596	107869596	+	Nonstop_Mutation	SNP	A	A	G			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chrX:107869596A>G	uc004eob.1	+	19	2719	c.2087A>G	c.(2086-2088)tAg>tGg	p.*696W	COL4A5_uc004enz.1_Intron|COL4A5_uc022ccg.1_Intron	NM_000495	NP_000486	P29400	CO4A5_HUMAN	Homo sapiens collagen, type IV, alpha 5 (COL4A5), transcript variant 1, mRNA.	0	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						TTTGGCATATAGTTTTAGGCA	0.373000									Alport syndrome with Diffuse Leiomyomatosis				33	76					0	0	1	0	0
GOLGA4	2803	broad.mit.edu	37	3	37323489	37323489	+	Missense_Mutation	SNP	G	G	A	rs7612972		TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr3:37323489G>A	uc003cgw.3	+	3	629	c.269G>A	c.(268-270)cGg>cAg	p.R90Q	GOLGA4_uc010hgr.2_Intron|GOLGA4_uc003cgv.3_Missense_Mutation_p.R68Q|GOLGA4_uc010hgs.3_Missense_Mutation_p.R68Q|GOLGA4_uc003cgx.3_5'Flank|GOLGA4_uc003cgu.2_Missense_Mutation_p.R90Q	NM_001172713	NP_001166184	Q13439	GOGA4_HUMAN	Homo sapiens golgin A4 (GOLGA4), transcript variant 1, mRNA.	68					Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						CTCCAGCTCCGGGTGCCCTCC	0.443000													3	92					0	0	1	0	0
PRPS2	5634	broad.mit.edu	37	X	12837725	12837725	+	Silent	SNP	C	C	T			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chrX:12837725C>T	uc004cva.3	+	4	782	c.639C>T	c.(637-639)gaC>gaT	p.D213D	PRPS2_uc004cvb.3_Silent_p.D210D|PRPS2_uc010nec.3_Intron	NM_001039091	NP_001034180	P11908	PRPS2_HUMAN	Homo sapiens phosphoribosyl pyrophosphate synthetase 2 (PRPS2), transcript variant 1, mRNA.	210	Binding of phosphoribosylpyrophosphate (Potential).				nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|urinary_tract(1)	16						TGGTGGGCGACGTGAAGGACC	0.552000													97	230					0	0	1	0	0
RHBDL3	162494	broad.mit.edu	37	17	30615975	30615975	+	Silent	SNP	C	C	T			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr17:30615975C>T	uc010csx.1	+	3	473	c.459C>T	c.(457-459)taC>taT	p.Y153Y	RHBDL3_uc002hhe.1_Silent_p.Y153Y|RHBDL3_uc010csw.1_Silent_p.Y145Y|RHBDL3_uc010csy.1_Silent_p.Y55Y|RHBDL3_uc002hhf.1_Silent_p.Y55Y			P58872	RHBL3_HUMAN	Homo sapiens rhomboid, veinlet-like 3 (Drosophila) (RHBDL3), mRNA.	153					proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(2)|skin(1)	16		Breast(31;0.116)|Ovarian(249;0.182)				GCAAGTGGTACTATGACAGCT	0.622000													34	52					0	0	1	0	0
CSF2RA	1438	broad.mit.edu	37	X	1407736	1407736	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chrX:1407736C>T	uc010ncv.2	+	3	454	c.428C>T	c.(427-429)aCg>aTg	p.T143M	CRLF2_uc022brt.1_Intron|CSF2RA_uc011mhb.1_Missense_Mutation_p.T143M|CSF2RA_uc010nct.2_Missense_Mutation_p.T143M|CSF2RA_uc004cpq.2_Missense_Mutation_p.T143M|CSF2RA_uc004cpn.2_Missense_Mutation_p.T143M|CSF2RA_uc004cpo.2_Missense_Mutation_p.T143M|CSF2RA_uc010ncu.2_Non-coding_Transcript|CSF2RA_uc011mhc.1_Missense_Mutation_p.T10M|CSF2RA_uc004cpp.2_Missense_Mutation_p.T143M|CSF2RA_uc004cpr.2_Missense_Mutation_p.T143M	NM_001161530	NP_001155002	P15509	CSF2R_HUMAN	Homo sapiens colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) (CSF2RA), transcript variant 8, mRNA.	143						extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(6)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	45		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	AGGGGTCCGACGGCCCCCCGT	0.473000													11	142					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41648055	41648055	+	Silent	SNP	G	G	A			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr21:41648055G>A	uc002yyq.1	-	10	2777	c.2325C>T	c.(2323-2325)gaC>gaT	p.D775D	DSCAM_uc002yyr.1_Non-coding_Transcript	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Homo sapiens Down syndrome cell adhesion molecule (DSCAM), transcript variant 1, mRNA.	775	Ig-like C2-type 8.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				ACTTGCTGACGTCTGCGCCCA	0.468000													5	92					0	0	1	0	0
GPR156	165829	broad.mit.edu	37	3	119886716	119886716	+	Missense_Mutation	SNP	C	C	A			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr3:119886716C>A	uc011bjf.2	-	8	1988	c.1608G>T	c.(1606-1608)gaG>gaT	p.E536D	GPR156_uc011bjg.2_Missense_Mutation_p.E532D	NM_153002	NP_694547	Q8NFN8	GP156_HUMAN	Homo sapiens G protein-coupled receptor 156 (GPR156), transcript variant 1, mRNA.	536						integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|prostate(1)|skin(1)	32				GBM - Glioblastoma multiforme(114;0.19)		GTGACCGCCGCTCTGGGGGCT	0.592000													6	315					0	0	1	0	0
INHBA	3624	broad.mit.edu	37	7	41739665	41739665	+	Missense_Mutation	SNP	A	A	G			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr7:41739665A>G	uc003thq.3	-	0	543	c.308T>C	c.(307-309)aTa>aCa	p.I103T	INHBA-AS1_uc003tht.4_Intron|INHBA_uc003thr.3_Missense_Mutation_p.I103T|INHBA-AS1_uc003ths.2_Intron	NM_002192	NP_002183	P08476	INHBA_HUMAN	Homo sapiens inhibin, beta A (INHBA), mRNA.	103					G1/S transition of mitotic cell cycle|cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(15)|lung(26)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						GTCATCCTCTATCTCCACATA	0.542000										TSP Lung(11;0.080)			6	535					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48501632	48501632	+	Missense_Mutation	SNP	A	A	G			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr4:48501632A>G	uc003gyh.1	-	63	9454	c.8849T>C	c.(8848-8850)aTa>aCa	p.I2950T	FRYL_uc003gye.1_Missense_Mutation_p.I132T|FRYL_uc003gyf.1_Missense_Mutation_p.I340T|FRYL_uc003gyg.1_Missense_Mutation_p.I1640T	NM_015030	NP_055845	O94915	FRYL_HUMAN	Homo sapiens FRY-like (FRYL), mRNA.	2950					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						ATGGAAATATATATGTAACAG	0.418000													4	98					0	0	1	0	0
SLC12A6	9990	broad.mit.edu	37	15	34537938	34537938	+	Silent	SNP	G	G	A			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr15:34537938G>A	uc001zhw.3	-	12	1944	c.1780C>T	c.(1780-1782)Ctg>Ttg	p.L594L	SLC12A6_uc001zhv.3_Silent_p.L543L|SLC12A6_uc001zhz.3_Non-coding_Transcript|SLC12A6_uc001zhx.3_Silent_p.L579L|SLC12A6_uc001zhy.3_Non-coding_Transcript|SLC12A6_uc001zia.3_Silent_p.L535L|SLC12A6_uc001zib.3_Silent_p.L585L|SLC12A6_uc001zic.3_Silent_p.L594L|SLC12A6_uc010bau.3_Silent_p.L594L|SLC12A6_uc001zid.3_Silent_p.L535L|SLC12A6_uc001zht.3_Non-coding_Transcript|SLC12A6_uc001zhu.3_Silent_p.L406L	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	Homo sapiens solute carrier family 12 (potassium/chloride transporters), member 6 (SLC12A6), transcript variant 1, mRNA.	594					angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|skin(3)	45		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	GCTTGTAGCAGCCTCGGTGCA	0.473000													5	89					0	0	1	0	0
PAWR	5074	broad.mit.edu	37	12	80083954	80083954	+	Frame_Shift_Del	DEL	T	T	-			TCGA-EM-A3AL-01A-11D-A202-08	TCGA-EM-A3AL-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	248fd0ed-f14c-40b8-9f14-e9c7adf16e22	876b9a95-f58f-427b-bfd1-6919adda895d	g.chr12:80083954delT	uc001syx.3	-	1	357	c.71delA	c.(70-72)aagfs	p.K24fs		NM_002583	NP_002574	Q96IZ0	PAWR_HUMAN	Homo sapiens PRKC, apoptosis, WT1, regulator (PAWR), mRNA.	24					actin filament bundle assembly|apoptosis|induction of apoptosis|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	actin binding|enzyme binding|leucine zipper domain binding|transcription corepressor activity			NS(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	8						GCGTTTCGCCTTCCACTCCTC	0.731													2	4	---	---	---	---