Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
BICD1	636	broad.mit.edu	37	12	32480404	32480404	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3ZK-01A-21D-A23M-08	TCGA-EL-A3ZK-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0e1f945-6fff-42da-942f-700994b8480a	8390a8cb-3b27-42e8-950c-e57ee71dd5b9	g.chr12:32480404G>A	uc001rku.3	+	4	1096	c.1015G>A	c.(1015-1017)Gaa>Aaa	p.E339K	BICD1_uc001rkv.3_Missense_Mutation_p.E339K|BICD1_uc010skd.2_Non-coding_Transcript	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	Homo sapiens bicaudal D homolog 1 (Drosophila) (BICD1), transcript variant 1, mRNA.	339					RNA processing|anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	Rab GTPase binding|cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|structural constituent of cytoskeleton			NS(1)|breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			GGTAGAGCGGGAAAAGGCCAT	0.507000													31	84					0	0	1	0	0
EPS8L1	54869	broad.mit.edu	37	19	55594786	55594786	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3ZK-01A-21D-A23M-08	TCGA-EL-A3ZK-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0e1f945-6fff-42da-942f-700994b8480a	8390a8cb-3b27-42e8-950c-e57ee71dd5b9	g.chr19:55594786G>A	uc002qis.4	+	12	1359	c.1255G>A	c.(1255-1257)Gag>Aag	p.E419K	EPS8L1_uc010ess.1_Missense_Mutation_p.E401K|EPS8L1_uc010est.1_Missense_Mutation_p.E419K|EPS8L1_uc010yfr.2_Missense_Mutation_p.E355K|EPS8L1_uc010esu.1_Non-coding_Transcript|EPS8L1_uc002qiu.3_Missense_Mutation_p.E292K|EPS8L1_uc002qiv.3_Missense_Mutation_p.E65K|EPS8L1_uc002qiw.3_Missense_Mutation_p.E166K	NM_133180	NP_573441	Q8TE68	ES8L1_HUMAN	Homo sapiens EPS8-like 1 (EPS8L1), transcript variant 1, mRNA.	419						cytoplasm				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|prostate(1)	12			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		ATACAGACCCGAGTTCTTCAG	0.672000													3	17					0	0	1	0	0
ADAMTS8	11095	broad.mit.edu	37	11	130289047	130289047	+	Silent	SNP	C	C	A			TCGA-EL-A3ZK-01A-21D-A23M-08	TCGA-EL-A3ZK-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0e1f945-6fff-42da-942f-700994b8480a	8390a8cb-3b27-42e8-950c-e57ee71dd5b9	g.chr11:130289047C>A	uc001qgg.4	-	1	1219	c.861G>T	c.(859-861)ggG>ggT	p.G287G		NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 8 (ADAMTS8), mRNA.	287	Peptidase M12B.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		GCAGTGTAAGCCCCCCATTGT	0.557000													80	184					0	0	1	0	0
CATSPERD	257062	broad.mit.edu	37	19	5749174	5749174	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3ZK-01A-21D-A23M-08	TCGA-EL-A3ZK-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0e1f945-6fff-42da-942f-700994b8480a	8390a8cb-3b27-42e8-950c-e57ee71dd5b9	g.chr19:5749174G>A	uc002mda.3	+	10	1028	c.967G>A	c.(967-969)Gtg>Atg	p.V323M	CATSPERD_uc010duj.1_5'UTR	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	Homo sapiens transmembrane protein 146 (TMEM146), mRNA.	323						integral to membrane											TCTGGGCATCGTGCCAAGTTC	0.438000													24	41					0	0	1	0	0
ATP11C	286410	broad.mit.edu	37	X	138869347	138869347	+	Missense_Mutation	SNP	C	C	G	rs147128476		TCGA-EL-A3ZK-01A-21D-A23M-08	TCGA-EL-A3ZK-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0e1f945-6fff-42da-942f-700994b8480a	8390a8cb-3b27-42e8-950c-e57ee71dd5b9	g.chrX:138869347C>G	uc004faz.3	-	14	1685	c.1586G>C	c.(1585-1587)aGa>aCa	p.R529T	ATP11C_uc004fay.3_Non-coding_Transcript|ATP11C_uc004fba.3_Missense_Mutation_p.R529T	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	Homo sapiens ATPase, class VI, type 11C (ATP11C), transcript variant 1, mRNA.	529					ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(31)|ovary(5)|prostate(1)|skin(3)	75	Acute lymphoblastic leukemia(192;0.000127)					TATTTCTTTTCTTTGGTTCTC	0.348000													22	59					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169474617	169474617	+	Splice_Site	SNP	G	G	A			TCGA-EL-A3ZK-01A-21D-A23M-08	TCGA-EL-A3ZK-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0e1f945-6fff-42da-942f-700994b8480a	8390a8cb-3b27-42e8-950c-e57ee71dd5b9	g.chr5:169474617G>A	uc003maf.3	+	40	4151	c.4071_splice	c.e40+1	p.R1357_splice	DOCK2_uc011der.2_Splice_Site|DOCK2_uc010jjm.3_Splice_Site_p.R849_splice	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	Homo sapiens dedicator of cytokinesis 2 (DOCK2), mRNA.	1357	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	GTP binding|GTPase binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding|electron carrier activity|heme binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCCTTCCTGCGGGTGAGTTTG	0.542000													5	83					0	0	1	0	0
ADRA2B	151	broad.mit.edu	37	2	96781258	96781258	+	Missense_Mutation	SNP	C	C	A			TCGA-EL-A3ZK-01A-21D-A23M-08	TCGA-EL-A3ZK-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0e1f945-6fff-42da-942f-700994b8480a	8390a8cb-3b27-42e8-950c-e57ee71dd5b9	g.chr2:96781258C>A	uc021vlh.1	-	0	631	c.631G>T	c.(631-633)Ggg>Tgg	p.G211W		NM_000682	NP_000673	P18089	ADA2B_HUMAN	Homo sapiens adrenergic, alpha-2B-, receptor (ADRA2B), mRNA.	211			G -> A (in dbSNP:rs9333568).		activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation	integral to plasma membrane	alpha2-adrenergic receptor activity|epinephrine binding|protein binding			endometrium(2)|large_intestine(2)|lung(9)|ovary(3)	16					Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	CCAGGCCCCCCCTTGGCCCTG	0.622000													13	29					0	0	1	0	0
PPEF1	5475	broad.mit.edu	37	X	18807364	18807364	+	Silent	SNP	A	A	G			TCGA-EL-A3ZK-01A-21D-A23M-08	TCGA-EL-A3ZK-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0e1f945-6fff-42da-942f-700994b8480a	8390a8cb-3b27-42e8-950c-e57ee71dd5b9	g.chrX:18807364A>G	uc004cyq.3	+	12	1519	c.1038A>G	c.(1036-1038)gaA>gaG	p.E346E	PPEF1_uc004cyp.3_Intron|PPEF1_uc004cyr.3_Silent_p.E346E|PPEF1_uc004cys.3_Silent_p.E346E|PPEF1_uc011mja.2_Silent_p.E281E|PPEF1_uc011mjb.2_Silent_p.E290E	NM_006240	NP_006231	O14829	PPE1_HUMAN	Homo sapiens protein phosphatase, EF-hand calcium binding domain 1 (PPEF1), transcript variant 1, mRNA.	346	Catalytic.				detection of stimulus involved in sensory perception|protein dephosphorylation		calcium ion binding|iron ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	43	Hepatocellular(33;0.183)					CTCCTACTGAACACTTAACAG	0.418000													7	122					0	0	1	0	0
RNF148	378925	broad.mit.edu	37	7	122342453	122342453	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3ZK-01A-21D-A23M-08	TCGA-EL-A3ZK-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0e1f945-6fff-42da-942f-700994b8480a	8390a8cb-3b27-42e8-950c-e57ee71dd5b9	g.chr7:122342453C>T	uc003vkk.1	-	0	569	c.352G>A	c.(352-354)Gtg>Atg	p.V118M	CADPS2_uc022akp.1_Intron|CADPS2_uc022akq.1_Intron|CADPS2_uc010lkq.3_Intron|CADPS2_uc022akr.1_Intron	NM_198085	NP_932351	Q8N7C7	RN148_HUMAN	Homo sapiens ring finger protein 148 (RNF148), mRNA.	118	PA.					integral to membrane	zinc ion binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(7)	16						TCTGCTGCCACGTTGATTTTA	0.483000													31	271					0	0	1	0	0
DNAJB9	4189	broad.mit.edu	37	7	108213643	108213643	+	Missense_Mutation	SNP	T	T	C			TCGA-EL-A3ZK-01A-21D-A23M-08	TCGA-EL-A3ZK-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0e1f945-6fff-42da-942f-700994b8480a	8390a8cb-3b27-42e8-950c-e57ee71dd5b9	g.chr7:108213643T>C	uc003vfn.3	+	2	887	c.518T>C	c.(517-519)aTg>aCg	p.M173T		NM_012328	NP_036460	Q9UBS3	DNJB9_HUMAN	Homo sapiens DnaJ (Hsp40) homolog, subfamily B, member 9 (DNAJB9), mRNA.	173					ER-associated protein catabolic process|protein folding	endoplasmic reticulum|nucleolus	heat shock protein binding|misfolded protein binding|unfolded protein binding			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|urinary_tract(1)	13						TTTGAAGATATGGAGAAAATG	0.393000													52	93					0	0	1	0	0
ZFP36	7538	broad.mit.edu	37	19	39898883	39898883	+	Silent	SNP	G	G	A			TCGA-EL-A3ZK-01A-21D-A23M-08	TCGA-EL-A3ZK-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0e1f945-6fff-42da-942f-700994b8480a	8390a8cb-3b27-42e8-950c-e57ee71dd5b9	g.chr19:39898883G>A	uc002olh.1	+	1	583	c.525G>A	c.(523-525)ccG>ccA	p.P175P		NM_003407	NP_003398	P26651	TTP_HUMAN	Homo sapiens zinc finger protein 36, C3H type, homolog (mouse) (ZFP36), mRNA.	175					positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	AU-rich element binding|DNA binding|mRNA binding|protein binding|single-stranded RNA binding|zinc ion binding			large_intestine(1)|lung(5)|pancreas(1)	7	all_cancers(60;6.54e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.53e-06)|Ovarian(47;0.0512)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TGGCGGCCCCGGGCCACCCTC	0.667000													48	96					0	0	1	0	0
TGFBRAP1	9392	broad.mit.edu	37	2	105924122	105924122	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3ZK-01A-21D-A23M-08	TCGA-EL-A3ZK-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0e1f945-6fff-42da-942f-700994b8480a	8390a8cb-3b27-42e8-950c-e57ee71dd5b9	g.chr2:105924122C>T	uc002tcq.3	-	1	721	c.637G>A	c.(637-639)Gtc>Atc	p.V213I	TGFBRAP1_uc002tcr.4_Missense_Mutation_p.V213I	NM_004257	NP_004248	Q8WUH2	TGFA1_HUMAN	Homo sapiens transforming growth factor, beta receptor associated protein 1 (TGFBRAP1), transcript variant 1, mRNA.	213	CNH.				regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	31						ATCCTCTTGACGATCGGCGGC	0.592000													13	161					0	0	1	0	0