Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
STT3A	3703	broad.mit.edu	37	11	125479386	125479386	+	Missense_Mutation	SNP	A	A	C			TCGA-DJ-A2PZ-01A-21D-A18F-08	TCGA-DJ-A2PZ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47823436-dc3b-4dc3-ad15-923a6121bd38	84d11fd9-30d2-4915-9f09-f42b4c0f10a3	g.chr11:125479386A>C	uc001qcd.2	+	9	1129	c.1019A>C	c.(1018-1020)aAg>aCg	p.K340T	STT3A_uc009zbm.2_Missense_Mutation_p.K340T|STT3A_uc001qce.2_Missense_Mutation_p.K340T|STT3A_uc010sbg.1_Missense_Mutation_p.K248T|STT3A_uc009zbn.2_Intron	NM_152713	NP_689926	P46977	STT3A_HUMAN	Homo sapiens STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) (STT3A), mRNA.	340					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity			NS(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(15)|skin(1)	33	all_hematologic(175;0.228)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0996)		TCTTATGCTAAGAACAACATC	0.473000													38	97					0	0	1	0	0
HSPH1	10808	broad.mit.edu	37	13	31725226	31725226	+	Missense_Mutation	SNP	C	C	A			TCGA-DJ-A2PZ-01A-21D-A18F-08	TCGA-DJ-A2PZ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47823436-dc3b-4dc3-ad15-923a6121bd38	84d11fd9-30d2-4915-9f09-f42b4c0f10a3	g.chr13:31725226C>A	uc001utl.3	-	6	1043	c.772G>T	c.(772-774)Gca>Tca	p.A258S	HSPH1_uc001utj.3_Missense_Mutation_p.A256S|HSPH1_uc001utk.3_Missense_Mutation_p.A256S|HSPH1_uc010aaw.3_Missense_Mutation_p.A215S|HSPH1_uc010tds.2_Missense_Mutation_p.A180S|HSPH1_uc010tdt.1_Non-coding_Transcript	NM_006644	NP_006635	Q92598	HS105_HUMAN	Homo sapiens heat shock 105kDa/110kDa protein 1 (HSPH1), mRNA.	256					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		TTGGATTTTGCATCCAACTTG	0.373000													25	48					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232629364	232629364	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A2PZ-01A-21D-A18F-08	TCGA-DJ-A2PZ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47823436-dc3b-4dc3-ad15-923a6121bd38	84d11fd9-30d2-4915-9f09-f42b4c0f10a3	g.chr1:232629364A>G	uc001hvg.3	-	1	1684	c.1526T>C	c.(1525-1527)gTa>gCa	p.V509A		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	Homo sapiens signal-induced proliferation-associated 1 like 2 (SIPA1L2), mRNA.	509					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GCTGACTGCTACTGGACCAAG	0.458000													5	304					0	0	1	0	0
CAPNS1	826	broad.mit.edu	37	19	36637183	36637183	+	Silent	SNP	C	C	A			TCGA-DJ-A2PZ-01A-21D-A18F-08	TCGA-DJ-A2PZ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47823436-dc3b-4dc3-ad15-923a6121bd38	84d11fd9-30d2-4915-9f09-f42b4c0f10a3	g.chr19:36637183C>A	uc002odi.1	+	8	847	c.690C>A	c.(688-690)atC>atA	p.I230I	CAPNS1_uc002odk.3_Silent_p.I230I|CAPNS1_uc002odj.3_Silent_p.I230I|CAPNS1_uc002odl.3_Silent_p.I230I	NM_001749	NP_001740	P04632	CPNS1_HUMAN	Homo sapiens calpain, small subunit 1 (CAPNS1), transcript variant 1, mRNA.	230	EF-hand 4.				positive regulation of cell proliferation	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			cervix(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	5	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			ACAACTTCATCAGCTGCTTGG	0.493000													91	136					0	0	1	0	0
ZC3H18	124245	broad.mit.edu	37	16	88675418	88675418	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A2PZ-01A-21D-A18F-08	TCGA-DJ-A2PZ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47823436-dc3b-4dc3-ad15-923a6121bd38	84d11fd9-30d2-4915-9f09-f42b4c0f10a3	g.chr16:88675418A>G	uc010voz.2	+	7	1437	c.1237A>G	c.(1237-1239)Agg>Ggg	p.R413G	ZC3H18_uc021tmm.1_Missense_Mutation_p.R413G|ZC3H18_uc010voy.1_Missense_Mutation_p.R272G|ZC3H18_uc002fky.3_Missense_Mutation_p.R389G|ZC3H18_uc010chw.3_5'Flank	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	Homo sapiens zinc finger CCCH-type containing 18 (ZC3H18), mRNA.	389						nucleus	nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(9)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	42				BRCA - Breast invasive adenocarcinoma(80;0.0542)		TGAGAATTTCAGGGTGCAGTA	0.408000													3	91					0	0	1	0	0
HBS1L	10767	broad.mit.edu	37	6	135314952	135314952	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A2PZ-01A-21D-A18F-08	TCGA-DJ-A2PZ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47823436-dc3b-4dc3-ad15-923a6121bd38	84d11fd9-30d2-4915-9f09-f42b4c0f10a3	g.chr6:135314952T>C	uc003qez.2	-	7	1234	c.1027A>G	c.(1027-1029)Atg>Gtg	p.M343V	HBS1L_uc003qey.2_Missense_Mutation_p.M179V|HBS1L_uc011ecy.1_Missense_Mutation_p.M67V|HBS1L_uc011ecz.1_Missense_Mutation_p.M179V|HBS1L_uc011eda.1_Missense_Mutation_p.M301V	NM_006620	NP_006611	Q9Y450	HBS1L_HUMAN	Homo sapiens HBS1-like (S. cerevisiae) (HBS1L), transcript variant 1, mRNA.	343					signal transduction		GTP binding|GTPase activity|translation elongation factor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	20	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0046)|GBM - Glioblastoma multiforme(68;0.00702)		GGAGCATCCATTAATGTAATA	0.373000													4	34					0	0	1	0	0
DNAJB11	51726	broad.mit.edu	37	3	186299235	186299235	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A2PZ-01A-21D-A18F-08	TCGA-DJ-A2PZ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47823436-dc3b-4dc3-ad15-923a6121bd38	84d11fd9-30d2-4915-9f09-f42b4c0f10a3	g.chr3:186299235A>G	uc003fqi.3	+	4	1267	c.532A>G	c.(532-534)Acc>Gcc	p.T178A		NM_016306	NP_057390	Q9UBS4	DJB11_HUMAN	Homo sapiens DnaJ (Hsp40) homolog, subfamily B, member 11 (DNAJB11), mRNA.	178					protein folding	endoplasmic reticulum lumen	heat shock protein binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|urinary_tract(2)	15	all_cancers(143;2.84e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.44e-20)	GBM - Glioblastoma multiforme(93;0.0476)		GATGCGGACCACCCAGCTGGG	0.517000													33	65					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-DJ-A2PZ-01A-21D-A18F-08	TCGA-DJ-A2PZ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47823436-dc3b-4dc3-ad15-923a6121bd38	84d11fd9-30d2-4915-9f09-f42b4c0f10a3	g.chr7:140453136A>T	uc003vwc.4	-	14	1860	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(41204)|p.V600K(615)|p.V600?(377)|p.V600R(99)|p.V600D(40)|p.V600_K601>E(30)|p.V600L(28)|p.V600A(24)|p.V600G(22)|p.V600M(22)|p.A598_T599insV(7)|p.T599_V600insT(7)|p.T599I(5)|p.V600Q(4)|p.T599_R603>I(4)|p.T599_V600insTT(3)|p.T599_V600insDFGLAT(2)|p.T599_V600>IAL(2)|p.V600_S605>EK(2)|p.T599T(2)|p.V600_S605>DV(2)|p.V600_S605>D(2)|p.V600_W604del(1)|p.V600V(1)|p.T599_V600insV(1)|p.V600>DLAT(1)|p.D594_T599del(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				18	47					0	0	1	0	0
GUCA2B	2981	broad.mit.edu	37	1	42620417	42620417	+	Missense_Mutation	SNP	C	C	A			TCGA-DJ-A2PZ-01A-21D-A18F-08	TCGA-DJ-A2PZ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47823436-dc3b-4dc3-ad15-923a6121bd38	84d11fd9-30d2-4915-9f09-f42b4c0f10a3	g.chr1:42620417C>A	uc001chc.1	+	1	187	c.157C>A	c.(157-159)Ccc>Acc	p.P53T		NM_007102	NP_009033	Q16661	GUC2B_HUMAN	Homo sapiens guanylate cyclase activator 2B (uroguanylin) (GUCA2B), mRNA.	53					excretion	extracellular region	calcium sensitive guanylate cyclase activator activity			breast(1)|large_intestine(2)	3	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ACAGTGGGCACCCAGCCCCCG	0.647000													16	34					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40364079	40364079	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A2PZ-01A-21D-A18F-08	TCGA-DJ-A2PZ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47823436-dc3b-4dc3-ad15-923a6121bd38	84d11fd9-30d2-4915-9f09-f42b4c0f10a3	g.chr19:40364079G>A	uc002omp.4	-	30	14571	c.14563C>T	c.(14563-14565)Cgc>Tgc	p.R4855C		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Homo sapiens Fc fragment of IgG binding protein (FCGBP), mRNA.	4855	VWFD 12.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCCAGGCAGCGGCCACAGCCT	0.642000													24	33					0	0	1	0	0
F7	2155	broad.mit.edu	37	13	113768272	113768272	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A2PZ-01A-21D-A18F-08	TCGA-DJ-A2PZ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47823436-dc3b-4dc3-ad15-923a6121bd38	84d11fd9-30d2-4915-9f09-f42b4c0f10a3	g.chr13:113768272C>T	uc001vsv.3	+	4	479	c.428C>T	c.(427-429)aCg>aTg	p.T143M	F7_uc010agp.1_Missense_Mutation_p.T136M|F7_uc001vsw.3_Missense_Mutation_p.T121M|F7_uc010tjt.2_Missense_Mutation_p.T74M	NM_000131	NP_000122	P08709	FA7_HUMAN	Homo sapiens coagulation factor VII (serum prothrombin conversion accelerator) (F7), transcript variant 1, mRNA.	143					anti-apoptosis|blood coagulation, extrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of leukocyte chemotaxis|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	Golgi lumen|endoplasmic reticulum lumen|plasma membrane	calcium ion binding|glycoprotein binding|serine-type endopeptidase activity			large_intestine(4)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0364)|all_epithelial(44;0.0393)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0737)|Epithelial(84;0.213)|BRCA - Breast invasive adenocarcinoma(86;0.218)		Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Menadione(DB00170)	AACTGTGAGACGCGTAAGGCC	0.632000													12	44					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46262900	46262900	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A2PZ-01A-21D-A18F-08	TCGA-DJ-A2PZ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47823436-dc3b-4dc3-ad15-923a6121bd38	84d11fd9-30d2-4915-9f09-f42b4c0f10a3	g.chr20:46262900A>G	uc002xtk.3	+	9	1334	c.1073A>G	c.(1072-1074)aAt>aGt	p.N358S	NCOA3_uc002xtl.3_Missense_Mutation_p.N358S|NCOA3_uc002xtn.3_Missense_Mutation_p.N358S|NCOA3_uc010ght.2_Missense_Mutation_p.N368S|NCOA3_uc002xtm.3_Missense_Mutation_p.N358S|NCOA3_uc010zyc.2_Missense_Mutation_p.N153S	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	Homo sapiens nuclear receptor coactivator 3 (NCOA3), transcript variant 1, mRNA.	358					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						CCTGTAACAAATGATCGACAT	0.398000													23	74					0	0	1	0	0
METTL11A	28989	broad.mit.edu	37	9	132397704	132397704	+	Silent	SNP	C	C	G	rs151072869		TCGA-DJ-A2PZ-01A-21D-A18F-08	TCGA-DJ-A2PZ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47823436-dc3b-4dc3-ad15-923a6121bd38	84d11fd9-30d2-4915-9f09-f42b4c0f10a3	g.chr9:132397704C>G	uc004byd.1	+	3	827	c.633C>G	c.(631-633)ccC>ccG	p.P211P	METTL11A_uc011mbs.1_3'UTR|METTL11A_uc010myw.1_Non-coding_Transcript|ASB6_uc004bye.1_3'UTR|ASB6_uc004byf.2_3'UTR|ASB6_uc010myx.2_3'UTR|ASB6_uc004byg.2_3'UTR|ASB6_uc011mbt.2_3'UTR	NM_014064	NP_054783	Q9BV86	NTM1A_HUMAN	Homo sapiens methyltransferase like 11A (METTL11A), mRNA.	211					N-terminal peptidyl-proline dimethylation|N-terminal peptidyl-serine dimethylation|N-terminal peptidyl-serine trimethylation|chromosome segregation|spindle organization	nucleus	protein binding|protein methyltransferase activity			breast(2)|endometrium(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)	7						AGAACCTCCCCGATGAGATCT	0.627000													3	107					0	0	1	0	0
CADM1	23705	broad.mit.edu	37	11	115102104	115102104	+	Missense_Mutation	SNP	G	G	C			TCGA-DJ-A2PZ-01A-21D-A18F-08	TCGA-DJ-A2PZ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47823436-dc3b-4dc3-ad15-923a6121bd38	84d11fd9-30d2-4915-9f09-f42b4c0f10a3	g.chr11:115102104G>C	uc001ppj.4	-	3	660	c.531C>G	c.(529-531)atC>atG	p.I177M	CADM1_uc001ppf.4_Missense_Mutation_p.I177M|CADM1_uc001ppi.4_Missense_Mutation_p.I177M|CADM1_uc001ppk.4_Missense_Mutation_p.I177M|CADM1_uc001ppl.3_Missense_Mutation_p.I177M	NM_014333	NP_055148	Q9BY67	CADM1_HUMAN	Homo sapiens cell adhesion molecule 1 (CADM1), transcript variant 1, mRNA.	177	Ig-like C2-type 1.				adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding	p.I177I(2)		cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(9)|ovary(2)|skin(1)	32	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		TGAACCACCTGATAGTCGTGG	0.463000													5	81					0	0	1	0	0
SYT11	23208	broad.mit.edu	37	1	155838393	155838393	+	Silent	SNP	C	C	T			TCGA-DJ-A2PZ-01A-21D-A18F-08	TCGA-DJ-A2PZ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47823436-dc3b-4dc3-ad15-923a6121bd38	84d11fd9-30d2-4915-9f09-f42b4c0f10a3	g.chr1:155838393C>T	uc001fmg.3	+	1	965	c.672C>T	c.(670-672)gaC>gaT	p.D224D	SYT11_uc010pgq.2_Intron	NM_152280	NP_689493	Q9BT88	SYT11_HUMAN	Homo sapiens synaptotagmin XI (SYT11), mRNA.	224	C2 1.					cell junction|synaptic vesicle membrane	protein binding|transporter activity	p.D224H(1)		breast(2)|central_nervous_system(1)|endometrium(1)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;0.000162)			CTGTGTTTGACGAGACCTTCA	0.557000													19	44					0	0	1	0	0
CDK13	8621	broad.mit.edu	37	7	40027812	40027812	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A2PZ-01A-21D-A18F-08	TCGA-DJ-A2PZ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47823436-dc3b-4dc3-ad15-923a6121bd38	84d11fd9-30d2-4915-9f09-f42b4c0f10a3	g.chr7:40027812C>T	uc003thh.4	+	1	2108	c.1826C>T	c.(1825-1827)cCg>cTg	p.P609L	CDK13_uc003thi.4_Missense_Mutation_p.P609L|CDK13_uc011kbf.2_5'UTR	NM_003718	NP_003709	Q14004	CDK13_HUMAN	Homo sapiens cyclin-dependent kinase 13 (CDK13), transcript variant 1, mRNA.	609					alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|RNA polymerase II carboxy-terminal domain kinase activity|cyclin-dependent protein kinase activity|protein binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(1)|pancreas(2)|prostate(2)|skin(5)|stomach(2)|urinary_tract(1)	49						ACATTACCACCGTTACCTTTG	0.393000													22	47					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64560157	64560157	+	Missense_Mutation	SNP	C	C	A			TCGA-DJ-A2PZ-01A-21D-A18F-08	TCGA-DJ-A2PZ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47823436-dc3b-4dc3-ad15-923a6121bd38	84d11fd9-30d2-4915-9f09-f42b4c0f10a3	g.chr14:64560157C>A	uc001xgl.3	+	60	12297	c.12067C>A	c.(12067-12069)Cat>Aat	p.H4023N	SYNE2_uc001xgm.3_Missense_Mutation_p.H4023N|SYNE2_uc021ruh.1_Missense_Mutation_p.H4056N|SYNE2_uc010apy.3_Missense_Mutation_p.H408N|SYNE2_uc010apx.1_Missense_Mutation_p.H415N	NM_182914	NP_878918	Q8WXH0	SYNE2_HUMAN	Homo sapiens spectrin repeat containing, nuclear envelope 2 (SYNE2), transcript variant 5, mRNA.	4023					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	SUN-KASH complex|Z disc|cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CTCCCTTGAACATATGTCACC	0.328000													4	94					0	0	1	0	0
ANKS1A	23294	broad.mit.edu	37	6	34985386	34985386	+	Silent	SNP	C	C	T			TCGA-DJ-A2PZ-01A-21D-A18F-08	TCGA-DJ-A2PZ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47823436-dc3b-4dc3-ad15-923a6121bd38	84d11fd9-30d2-4915-9f09-f42b4c0f10a3	g.chr6:34985386C>T	uc003ojx.4	+	10	1702	c.1560C>T	c.(1558-1560)ctC>ctT	p.L520L	ANKS1A_uc011dst.2_Silent_p.L60L|ANKS1A_uc010jvp.2_Intron	NM_015245	NP_056060	Q92625	ANS1A_HUMAN	Homo sapiens ankyrin repeat and sterile alpha motif domain containing 1A (ANKS1A), mRNA.	520						cytoplasm	protein binding			cervix(2)|endometrium(3)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31						TCCAGCTGCTCTGTACCGCTG	0.692000													7	35					0	0	1	0	0
HIST2H2AC	8338	broad.mit.edu	37	1	149858710	149858710	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DJ-A2PZ-01A-21D-A18F-08	TCGA-DJ-A2PZ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47823436-dc3b-4dc3-ad15-923a6121bd38	84d11fd9-30d2-4915-9f09-f42b4c0f10a3	g.chr1:149858710delG	uc001etd.3	+	0	186	c.186delG	c.(184-186)gagfs	p.E62fs	HIST2H2BE_uc001etc.3_5'Flank	NM_003517	NP_003508	Q16777	H2A2C_HUMAN	Homo sapiens histone cluster 2, H2ac (HIST2H2AC), mRNA.	62					nucleosome assembly	nucleosome|nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|ovary(1)|skin(1)	20	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			TGACCGCCGAGATCCTGGAGC	0.672													37	63	---	---	---	---					
RBBP6	5930	broad.mit.edu	37	16	24581020	24581021	+	Frame_Shift_Ins	INS	-	-	AC			TCGA-DJ-A2PZ-01A-21D-A18F-08	TCGA-DJ-A2PZ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47823436-dc3b-4dc3-ad15-923a6121bd38	84d11fd9-30d2-4915-9f09-f42b4c0f10a3	g.chr16:24581020_24581021insAC	uc002dmh.3	+	16	4049_4050	c.3009_3010insAC	c.(3007-3012)gaaaaafs	p.E1003fs	RBBP6_uc010vcb.1_Frame_Shift_Ins_p.E870fs|RBBP6_uc002dmi.3_Frame_Shift_Ins_p.E969fs|RBBP6_uc010bxr.3_Intron|RBBP6_uc002dmk.3_Frame_Shift_Ins_p.E836fs	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	Homo sapiens retinoblastoma binding protein 6 (RBBP6), transcript variant 1, mRNA.	1003	Interaction with RB1 (By similarity).				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		CAGTGTCTGAAAAAGACAAGAG	0.371													45	65	---	---	---	---