Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KCMF1	56888	broad.mit.edu	37	2	85276643	85276643	+	Silent	SNP	C	C	T			TCGA-DJ-A1QO-01A-11D-A14W-08	TCGA-DJ-A1QO-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49920921-d55d-47bd-a264-4f42dbdf8b30	0f82f0a9-494f-45a2-b451-9a06cd7b11e0	g.chr2:85276643C>T	uc002sox.4	+	5	1100	c.756C>T	c.(754-756)cgC>cgT	p.R252R		NM_020122	NP_064507	Q9P0J7	KCMF1_HUMAN	Homo sapiens potassium channel modulatory factor 1 (KCMF1), mRNA.	252						intracellular	ligase activity|zinc ion binding			ovary(3)	3						AGACCGCACGCAACGCAACCC	0.537000													8	40					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2027691	2027691	+	Missense_Mutation	SNP	G	G	C			TCGA-DJ-A1QO-01A-11D-A14W-08	TCGA-DJ-A1QO-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49920921-d55d-47bd-a264-4f42dbdf8b30	0f82f0a9-494f-45a2-b451-9a06cd7b11e0	g.chr8:2027691G>C	uc003wpx.4	+	12	1651	c.1513G>C	c.(1513-1515)Gaa>Caa	p.E505Q	MYOM2_uc011kwi.2_Intron	NM_003970	NP_003961	P54296	MYOM2_HUMAN	Homo sapiens myomesin (M-protein) 2, 165kDa (MYOM2), mRNA.	505					muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		GGATGACCTTGAAGGTAAGTA	0.512000													6	230					0	0	1	0	0
ZNF141	7700	broad.mit.edu	37	4	366799	366799	+	Silent	SNP	A	A	G			TCGA-DJ-A1QO-01A-11D-A14W-08	TCGA-DJ-A1QO-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49920921-d55d-47bd-a264-4f42dbdf8b30	0f82f0a9-494f-45a2-b451-9a06cd7b11e0	g.chr4:366799A>G	uc003gaa.2	+	3	750	c.573A>G	c.(571-573)gtA>gtG	p.V191V	ZNF141_uc003gab.3_Intron	NM_003441	NP_003432	Q15928	ZN141_HUMAN	Homo sapiens zinc finger protein 141 (ZNF141), mRNA.	191					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(3)|large_intestine(5)|lung(8)|upper_aerodigestive_tract(1)	18						AACATAAGGTAATTCATGCTG	0.343000													18	71					0	0	1	0	0
TAAR5	9038	broad.mit.edu	37	6	132910122	132910122	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A1QO-01A-11D-A14W-08	TCGA-DJ-A1QO-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49920921-d55d-47bd-a264-4f42dbdf8b30	0f82f0a9-494f-45a2-b451-9a06cd7b11e0	g.chr6:132910122G>A	uc003qdk.2	-	0	756	c.704C>T	c.(703-705)aCa>aTa	p.T235I		NM_003967	NP_003958	O14804	TAAR5_HUMAN	Homo sapiens trace amine associated receptor 5 (TAAR5), mRNA.	235					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	32	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00604)|GBM - Glioblastoma multiforme(226;0.015)		TTTGCTCAATGTGGTAATCTG	0.502000													18	29					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78583811	78583811	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A1QO-01A-11D-A14W-08	TCGA-DJ-A1QO-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49920921-d55d-47bd-a264-4f42dbdf8b30	0f82f0a9-494f-45a2-b451-9a06cd7b11e0	g.chr12:78583811C>T	uc001syp.3	+	33	6276	c.6103C>T	c.(6103-6105)Cct>Tct	p.P2035S	NAV3_uc001syo.3_Missense_Mutation_p.P2013S|NAV3_uc010sub.2_Missense_Mutation_p.P1492S|NAV3_uc009zsf.3_Missense_Mutation_p.P844S	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	Homo sapiens neuron navigator 3 (NAV3), mRNA.	2035						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TACGCTGATTCCTAAACCAAT	0.353000										HNSCC(70;0.22)			37	56					0	0	1	0	0
DNAI2	64446	broad.mit.edu	37	17	72278108	72278108	+	Missense_Mutation	SNP	T	T	A			TCGA-DJ-A1QO-01A-11D-A14W-08	TCGA-DJ-A1QO-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49920921-d55d-47bd-a264-4f42dbdf8b30	0f82f0a9-494f-45a2-b451-9a06cd7b11e0	g.chr17:72278108T>A	uc002jkf.3	+	1	262	c.152T>A	c.(151-153)aTc>aAc	p.I51N	DNAI2_uc002jkg.3_Missense_Mutation_p.I51N|DNAI2_uc010dfp.3_Non-coding_Transcript	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	Homo sapiens dynein, axonemal, intermediate chain 2 (DNAI2), transcript variant 1, mRNA.	51					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(2)|lung(19)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						GACACGGGCATCCAGTGCTCG	0.662000									Kartagener syndrome				27	53					0	0	1	0	0
CNGA4	1262	broad.mit.edu	37	11	6261928	6261928	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DJ-A1QO-01A-11D-A14W-08	TCGA-DJ-A1QO-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49920921-d55d-47bd-a264-4f42dbdf8b30	0f82f0a9-494f-45a2-b451-9a06cd7b11e0	g.chr11:6261928C>T	uc001mco.3	+	3	1019	c.904C>T	c.(904-906)Cga>Tga	p.R302*	CNGA4_uc010raa.2_Nonsense_Mutation_p.R71*|CNGA4_uc001mcn.3_Nonsense_Mutation_p.R262*	NM_001037329	NP_001032406	Q8IV77	CNGA4_HUMAN	Homo sapiens cyclic nucleotide gated channel alpha 4 (CNGA4), mRNA.	302					response to stimulus|sensory perception of smell		cAMP binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(24)|prostate(3)|skin(1)	40		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCTGGAGCGGCGAGTTATTGA	0.542000													14	40					0	0	1	0	0
ARID1B	57492	broad.mit.edu	37	6	157521926	157521926	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DJ-A1QO-01A-11D-A14W-08	TCGA-DJ-A1QO-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49920921-d55d-47bd-a264-4f42dbdf8b30	0f82f0a9-494f-45a2-b451-9a06cd7b11e0	g.chr6:157521926C>T	uc003qqn.3	+	17	4318	c.4318C>T	c.(4318-4320)Cag>Tag	p.Q1440*	ARID1B_uc003qqo.3_Nonsense_Mutation_p.Q1400*|ARID1B_uc003qqp.3_Nonsense_Mutation_p.Q1387*	NM_020732	NP_059989	Q8NFD5	ARI1B_HUMAN	Homo sapiens AT rich interactive domain 1B (SWI1-like) (ARID1B), transcript variant 2, mRNA.	1387					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CAGCAGCCAGCAGCAGGAGAT	0.592000													26	44					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179580380	179580380	+	Missense_Mutation	SNP	C	C	G			TCGA-DJ-A1QO-01A-11D-A14W-08	TCGA-DJ-A1QO-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49920921-d55d-47bd-a264-4f42dbdf8b30	0f82f0a9-494f-45a2-b451-9a06cd7b11e0	g.chr2:179580380C>G	uc021vsy.1	-	85	22254	c.22029G>C	c.(22027-22029)gaG>gaC	p.E7343D	TTN_uc021vsz.1_Intron|TTN_uc021vta.1_Intron|TTN_uc021vtb.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E4004D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	Homo sapiens titin (TTN), transcript variant N2-A, mRNA.	8270	Ig-like 55.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAATTTCAGTCTCGTCCTTAT	0.408000													9	18					0	0	1	0	0
HTATIP2	10553	broad.mit.edu	37	11	20404724	20404724	+	Silent	SNP	G	G	A			TCGA-DJ-A1QO-01A-11D-A14W-08	TCGA-DJ-A1QO-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49920921-d55d-47bd-a264-4f42dbdf8b30	0f82f0a9-494f-45a2-b451-9a06cd7b11e0	g.chr11:20404724G>A	uc001mpx.2	+	5	873	c.804G>A	c.(802-804)ggG>ggA	p.G268G	HTATIP2_uc009yia.1_Silent_p.G234G|HTATIP2_uc009yib.1_Silent_p.G234G|HTATIP2_uc001mpz.2_Silent_p.G234G	NM_001098520	NP_006401	Q9BUP3	HTAI2_HUMAN	Homo sapiens HIV-1 Tat interactive protein 2, 30kDa (HTATIP2), transcript variant 1, mRNA.	234					angiogenesis|anti-apoptosis|apoptosis|cell differentiation|cellular amino acid metabolic process|induction of apoptosis|interspecies interaction between organisms|nuclear import|regulation of angiogenesis|regulation of transcription from RNA polymerase II promoter	cytoplasm|nuclear envelope	NAD binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|protein binding|transcription coactivator activity			large_intestine(2)|lung(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	8						ATGACCTGGGGAAAGCGCATG	0.473000													4	13					0	0	1	0	0
PRRC2A	7916	broad.mit.edu	37	6	31602045	31602045	+	Missense_Mutation	SNP	C	C	A	rs146122581	byFrequency	TCGA-DJ-A1QO-01A-11D-A14W-08	TCGA-DJ-A1QO-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49920921-d55d-47bd-a264-4f42dbdf8b30	0f82f0a9-494f-45a2-b451-9a06cd7b11e0	g.chr6:31602045C>A	uc003nvb.4	+	18	5001	c.4752C>A	c.(4750-4752)ttC>ttA	p.F1584L	PRRC2A_uc011dnv.1_Intron|PRRC2A_uc003nvc.4_Missense_Mutation_p.F1584L	NM_080686	NP_542417	P48634	PRC2A_HUMAN	Homo sapiens proline-rich coiled-coil 2A (PRRC2A), transcript variant 1, mRNA.	1584	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						GCTCTGGATTCTTGGGCTCTA	0.527000													8	489					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-DJ-A1QO-01A-11D-A14W-08	TCGA-DJ-A1QO-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49920921-d55d-47bd-a264-4f42dbdf8b30	0f82f0a9-494f-45a2-b451-9a06cd7b11e0	g.chr7:140453136A>T	uc003vwc.4	-	14	1860	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(41204)|p.V600K(615)|p.V600?(377)|p.V600R(99)|p.V600D(40)|p.V600_K601>E(30)|p.V600L(28)|p.V600A(24)|p.V600G(22)|p.V600M(22)|p.A598_T599insV(7)|p.T599_V600insT(7)|p.T599I(5)|p.V600Q(4)|p.T599_R603>I(4)|p.T599_V600insTT(3)|p.T599_V600insDFGLAT(2)|p.T599_V600>IAL(2)|p.V600_S605>EK(2)|p.T599T(2)|p.V600_S605>DV(2)|p.V600_S605>D(2)|p.V600_W604del(1)|p.V600V(1)|p.T599_V600insV(1)|p.V600>DLAT(1)|p.D594_T599del(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				15	38					0	0	1	0	0
RBM4B	83759	broad.mit.edu	37	11	66436191	66436191	+	Missense_Mutation	SNP	T	T	A			TCGA-DJ-A1QO-01A-11D-A14W-08	TCGA-DJ-A1QO-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49920921-d55d-47bd-a264-4f42dbdf8b30	0f82f0a9-494f-45a2-b451-9a06cd7b11e0	g.chr11:66436191T>A	uc001oja.3	-	1	1653	c.984A>T	c.(982-984)ttA>ttT	p.L328F	RBM4B_uc001ojb.3_Missense_Mutation_p.L328F	NM_031492	NP_113680	Q9BQ04	RBM4B_HUMAN	Homo sapiens RNA binding motif protein 4B (RBM4B), mRNA.	328	Interaction with TNPO3 (By similarity).				RNA splicing|circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing	nucleolus	RNA binding|nucleotide binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(4)|lung(1)|urinary_tract(2)	10						AAGCCTGAGATAATTCACTCT	0.552000													19	40					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90084066	90084066	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A1QO-01A-11D-A14W-08	TCGA-DJ-A1QO-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49920921-d55d-47bd-a264-4f42dbdf8b30	0f82f0a9-494f-45a2-b451-9a06cd7b11e0	g.chr5:90084066A>G	uc003kju.3	+	67	13928	c.13832A>G	c.(13831-13833)aAa>aGa	p.K4611R	GPR98_uc003kjt.3_Missense_Mutation_p.K2317R|GPR98_uc003kjw.3_Missense_Mutation_p.K272R	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	Homo sapiens G protein-coupled receptor 98 (GPR98), transcript variant 1, mRNA.	4611	Calx-beta 31.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	G-protein coupled receptor activity|calcium ion binding			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTCATTATTAAACTTCATCTT	0.348000													19	29					0	0	1	0	0
DNTT	1791	broad.mit.edu	37	10	98087290	98087290	+	Silent	SNP	C	C	T			TCGA-DJ-A1QO-01A-11D-A14W-08	TCGA-DJ-A1QO-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49920921-d55d-47bd-a264-4f42dbdf8b30	0f82f0a9-494f-45a2-b451-9a06cd7b11e0	g.chr10:98087290C>T	uc001kmf.3	+	6	1110	c.940C>T	c.(940-942)Ctg>Ttg	p.L314L	DNTT_uc001kmg.3_Silent_p.L314L	NM_004088	NP_004079	P04053	TDT_HUMAN	Homo sapiens deoxynucleotidyltransferase, terminal (DNTT), transcript variant 1, mRNA.	314	Mediates interaction with DNTTIP2.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	27		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		CGTCAGTGTGCTGGTTAAAGA	0.522000													4	209					0	0	1	0	0
ZBTB40	9923	broad.mit.edu	37	1	22816958	22816958	+	Missense_Mutation	SNP	G	G	T			TCGA-DJ-A1QO-01A-11D-A14W-08	TCGA-DJ-A1QO-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49920921-d55d-47bd-a264-4f42dbdf8b30	0f82f0a9-494f-45a2-b451-9a06cd7b11e0	g.chr1:22816958G>T	uc001bft.2	+	2	1028	c.517G>T	c.(517-519)Gct>Tct	p.A173S	ZBTB40_uc001bfu.2_Missense_Mutation_p.A173S|ZBTB40_uc009vqi.1_Missense_Mutation_p.A173S	NM_001083621	NP_055685	Q9NUA8	ZBT40_HUMAN	Homo sapiens zinc finger and BTB domain containing 40 (ZBTB40), transcript variant 1, mRNA.	173					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(4)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		CCCTGTGAAAGCTGAGACTGA	0.542000													13	219					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77673090	77673090	+	Silent	SNP	C	C	T			TCGA-DJ-A1QO-01A-11D-A14W-08	TCGA-DJ-A1QO-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49920921-d55d-47bd-a264-4f42dbdf8b30	0f82f0a9-494f-45a2-b451-9a06cd7b11e0	g.chr13:77673090C>T	uc021rks.1	-	55	8466	c.8199G>A	c.(8197-8199)gaG>gaA	p.E2733E	MYCBP2_uc010aev.3_Silent_p.E2099E|MYCBP2_uc001vkg.1_Silent_p.E218E|MYCBP2_uc010aew.3_Silent_p.E81E	NM_015057	NP_055872	O75592	MYCB2_HUMAN	Homo sapiens MYC binding protein 2 (MYCBP2), mRNA.	2695	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TAGAGGACAGCTCTGATTTTC	0.413000													32	66					0	0	1	0	0
SAMD15	161394	broad.mit.edu	37	14	77844257	77844257	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A1QO-01A-11D-A14W-08	TCGA-DJ-A1QO-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49920921-d55d-47bd-a264-4f42dbdf8b30	0f82f0a9-494f-45a2-b451-9a06cd7b11e0	g.chr14:77844257G>A	uc001xtq.1	+	0	496	c.496G>A	c.(496-498)Gaa>Aaa	p.E166K	TMED8_uc001xto.1_5'Flank|SAMD15_uc021rwt.1_Missense_Mutation_p.E166K	NM_001010860	NP_001010860	Q9P1V8	SAM15_HUMAN	Homo sapiens sterile alpha motif domain containing 15 (SAMD15), mRNA.	166										breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GCCACCAACGGAAACCATGTC	0.493000													35	82					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140222123	140222123	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A1QO-01A-11D-A14W-08	TCGA-DJ-A1QO-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49920921-d55d-47bd-a264-4f42dbdf8b30	0f82f0a9-494f-45a2-b451-9a06cd7b11e0	g.chr5:140222123C>T	uc003lhs.2	+	0	1217	c.1217C>T	c.(1216-1218)tCg>tTg	p.S406L	PCDHAC2_uc003lha.2_Intron|PCDHAC2_uc003lhb.2_Intron|PCDHAC2_uc003lhd.2_Intron|PCDHAC2_uc003lhf.2_Intron|PCDHAC2_uc003lhh.1_Intron|PCDHAC2_uc003lhi.2_Intron|PCDHAC2_uc003lhl.2_Intron|PCDHAC2_uc003lhk.1_Intron|PCDHAC2_uc003lho.2_Intron|PCDHAC2_uc003lhn.2_Intron|PCDHAC2_uc003lhq.2_Intron|PCDHAC2_uc003lhr.1_Missense_Mutation_p.S406L	NM_018911	NP_061734	Q9Y5I4	PCDC2_HUMAN	Homo sapiens protocadherin alpha 8 (PCDHA8), transcript variant 1, mRNA.	420	Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AATTACTACTCGTTGGTGCTG	0.632000													71	146					0	0	1	0	0
MN1	4330	broad.mit.edu	37	22	28194931	28194933	+	In_Frame_Del	DEL	TGT	TGT	-	rs34890218		TCGA-DJ-A1QO-01A-11D-A14W-08	TCGA-DJ-A1QO-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	49920921-d55d-47bd-a264-4f42dbdf8b30	0f82f0a9-494f-45a2-b451-9a06cd7b11e0	g.chr22:28194931_28194933delTGT	uc003adj.3	-	0	2554_2556	c.1599_1601delACA	c.(1597-1602)caacag>cag	p.533_534QQ>Q		NM_002430	NP_002421	Q10571	MN1_HUMAN	Homo sapiens meningioma (disrupted in balanced translocation) 1 (MN1), mRNA.	533	Poly-Gln.						binding	p.Q550_R551insQ(1)|p.Q532Q(1)		NS(1)|breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	45						ctgctgctgctgttgctgctgct	0.650			T	ETV6	"""AML, meningioma"""								4	7	---	---	---	---