Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLC22A4	6583	broad.mit.edu	37	5	131630375	131630375	+	Silent	SNP	C	C	T			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr5:131630375C>T	ENST00000200652.3	+	1	240	c.66C>T	c.(64-66)ttC>ttT	p.F22F	P4HA2_ENST00000471826.1_Intron	NM_003059.2	NP_003050.2	Q9H015	S22A4_HUMAN	solute carrier family 22 (organic cation/zwitterion transporter), member 4	22					body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity			endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|urinary_tract(1)	16		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	GCCTCATCTTCTTCCTGCTCA	0.637000													5	74					0	0	8.12818e-05	0	0
KRT6C	286887	broad.mit.edu	37	12	52865071	52865071	+	Missense_Mutation	SNP	G	G	T	rs143318086		TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr12:52865071G>T	ENST00000252250.6	-	5	969	c.922C>A	c.(922-924)Cag>Aag	p.Q308K		NM_173086.4	NP_775109.2	P48668	K2C6C_HUMAN	keratin 6C	308	Coil 1B.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|prostate(2)|skin(2)	23				BRCA - Breast invasive adenocarcinoma(357;0.0828)		GTCTGCATCTGGGACAGCTCC	0.502000													28	230					3.6622e-26	2.77513e-24	0.000109025	1	0
ZFR2	23217	broad.mit.edu	37	19	3821378	3821378	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr19:3821378C>T	ENST00000262961.4	-	10	1601	c.1591G>A	c.(1591-1593)Gag>Aag	p.E531K		NM_015174.1	NP_055989.1	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2	531						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(5)|pancreas(1)|prostate(1)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		TCCAGCCGCTCCTCCGCCAGG	0.697000													7	10					0	0	8.12818e-05	0	0
TTN	7273	broad.mit.edu	37	2	179640610	179640610	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr2:179640610G>A	ENST00000589042.1	-	28	6205	c.5981C>T	c.(5980-5982)tCg>tTg	p.S1994L	TTN_ENST00000359218.5_Missense_Mutation_p.S1948L|TTN_ENST00000360870.5_Missense_Mutation_p.S1994L|TTN_ENST00000591111.1_Missense_Mutation_p.S1994L|TTN_ENST00000342992.6_Missense_Mutation_p.S1994L|TTN_ENST00000342175.6_Missense_Mutation_p.S1948L|TTN_ENST00000460472.2_Missense_Mutation_p.S1948L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1747							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGCTCTTCCGACTCTTCAGG	0.438000													7	9					0	0	0.000157383	0	0
PSPC1	55269	broad.mit.edu	37	13	20279862	20279862	+	Silent	SNP	G	G	A			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr13:20279862G>A	ENST00000338910.4	-	8	1485	c.1326C>T	c.(1324-1326)gcC>gcT	p.A442A		NM_001042414.2	NP_001035879.1	Q8WXF1	PSPC1_HUMAN	paraspeckle component 1	442	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleolus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23		all_cancers(29;1.25e-22)|all_lung(29;1.97e-20)|all_epithelial(30;2.29e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;4.63e-06)|Epithelial(112;2.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00256)|Lung(94;0.00975)|LUSC - Lung squamous cell carcinoma(192;0.0483)		CTGGTCCCATGGCAGGACCAG	0.463000													5	19					0	0	8.12818e-05	0	0
PLXNC1	10154	broad.mit.edu	37	12	94637742	94637742	+	Nonsense_Mutation	SNP	A	A	T			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr12:94637742A>T	ENST00000258526.4	+	12	2578	c.2329A>T	c.(2329-2331)Aga>Tga	p.R777*		NM_005761.2	NP_005752.1	O60486	PLXC1_HUMAN	plexin C1	777					axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(12)|lung(30)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						CATGATGGGCAGAAATTTTGA	0.328000													12	3					0	0	3.45872e-05	0	0
PES1	23481	broad.mit.edu	37	22	30984115	30984115	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr22:30984115T>C	ENST00000354694.6	-	3	257	c.151A>G	c.(151-153)Aag>Gag	p.K51E	PES1_ENST00000405677.1_5'UTR|PES1_ENST00000335214.6_Missense_Mutation_p.K51E|PES1_ENST00000402281.1_5'UTR|PES1_ENST00000402284.3_Missense_Mutation_p.K51E	NM_001243225.1|NM_014303.3	NP_001230154.1|NP_055118.1	O00541	PESC_HUMAN	pescadillo ribosomal biogenesis factor 1	51	Required for 28S ribosomal RNA processing.|Sufficient for nucleolar localization.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell cycle	chromosome|nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	29						ACCTTCTTCTTGTGTTTGGGT	0.478000													42	62					0	0	0.000147903	0	0
MAP3K4	4216	broad.mit.edu	37	6	161513084	161513084	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr6:161513084C>T	ENST00000392142.4	+	13	3326	c.3178C>T	c.(3178-3180)Cag>Tag	p.Q1060*	MAP3K4_ENST00000348824.7_Nonsense_Mutation_p.Q1060*|MAP3K4_ENST00000366920.2_Nonsense_Mutation_p.Q1060*|MAP3K4_ENST00000366919.2_Nonsense_Mutation_p.Q1060*	NM_005922.2	NP_005913.2	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1060					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		GGAGTTTAGACAGAAGATAGG	0.358000													72	49					0	0	0.000147903	0	0
CD99	4267	broad.mit.edu	37	X	2640667	2640667	+	Splice_Site	SNP	G	G	T			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chrX:2640667G>T	ENST00000381192.3	+	6	444		c.e6-1		CD99_ENST00000381187.3_Splice_Site|CD99_ENST00000482405.2_Splice_Site|CD99_ENST00000381184.1_Splice_Site	NM_001277710.1|NM_002414.3	NP_001264639.1|NP_002405.1	P14209	CD99_HUMAN	CD99 molecule						cell adhesion	cytoplasm|integral to plasma membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)	11						TTCTTTCCTAGGTAGCTTTTC	0.448000													31	139					1.36161e-19	9.84901e-18	0.000132358	1	0
BAGE2	85319	broad.mit.edu	37	21	11058340	11058340	+	RNA	SNP	A	A	C	rs28617310	by1000genomes	TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr21:11058340A>C	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGGGTAAAGGAGAGAAATCTC	0.363000													15	56					0	0	5.01169e-05	0	0
USP35	57558	broad.mit.edu	37	11	77917004	77917004	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr11:77917004G>T	ENST00000441408.2	+	5	633	c.68G>T	c.(67-69)cGg>cTg	p.R23L	USP35_ENST00000530267.1_Silent_p.T6T|USP35_ENST00000530535.1_Intron|USP35_ENST00000529308.1_Silent_p.T438T|USP35_ENST00000526425.1_Silent_p.T169T			Q9P2H5	UBP35_HUMAN	ubiquitin specific peptidase 35	0					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(3)|urinary_tract(1)	23	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			AGTCAGACACGGGCAAGATTG	0.557000													79	5778					1.64113e-05	0.00107326	0.000175454	1	0
ODF1	4956	broad.mit.edu	37	8	103572783	103572783	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr8:103572783C>T	ENST00000285402.3	+	2	580	c.424C>T	c.(424-426)Cga>Tga	p.R142*	ODF1_ENST00000518835.1_5'UTR	NM_024410.3	NP_077721.2	Q14990	ODFP1_HUMAN	outer dense fiber of sperm tails 1	142					cell differentiation|multicellular organismal development|spermatogenesis	outer dense fiber	structural molecule activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(14;2.76e-05)|all_epithelial(15;4.54e-08)|Lung NSC(17;4.08e-05)|all_lung(17;9.15e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000125)|STAD - Stomach adenocarcinoma(118;0.0826)			AGTCAAAGTTCGAGTGAAGGA	0.448000													22	34					0	0	4.16121e-05	0	0
ELAVL4	1996	broad.mit.edu	37	1	50659525	50659525	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr1:50659525T>C	ENST00000371824.1	+	4	700	c.443T>C	c.(442-444)cTg>cCg	p.L148P	ELAVL4_ENST00000371823.4_Missense_Mutation_p.L148P|ELAVL4_ENST00000371819.1_Missense_Mutation_p.L153P|ELAVL4_ENST00000357083.4_Missense_Mutation_p.L165P|ELAVL4_ENST00000448907.2_Missense_Mutation_p.L151P|ELAVL4_ENST00000371827.1_Missense_Mutation_p.L148P|ELAVL4_ENST00000371821.1_Missense_Mutation_p.L153P			P26378	ELAV4_HUMAN	ELAV like neuron-specific RNA binding protein 4	148	RRM 2.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			NS(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	32						CAGAAGGAACTGGAGCAACTT	0.468000													4	11					0	0	0.00024832	0	0
ITGAM	3684	broad.mit.edu	37	16	31284753	31284753	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr16:31284753G>A	ENST00000544665.3	+	8	843	c.772G>A	c.(772-774)Gat>Aat	p.D258N	ITGAM_ENST00000287497.8_Missense_Mutation_p.D258N	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	258	VWFA.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						TGTCATCACGGATGGAGAAAA	0.498000													14	28					0	0	0.000219431	0	0
GALNT14	79623	broad.mit.edu	37	2	31155012	31155012	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr2:31155012G>T	ENST00000349752.5	-	10	1619	c.980C>A	c.(979-981)cCc>cAc	p.P327H	GALNT14_ENST00000356174.3_Missense_Mutation_p.P294H|GALNT14_ENST00000324589.5_Missense_Mutation_p.P332H|GALNT14_ENST00000486564.1_5'UTR|GALNT14_ENST00000420311.2_Missense_Mutation_p.P292H|GALNT14_ENST00000406653.1_Missense_Mutation_p.P307H	NM_024572.3	NP_078848.2	Q96FL9	GLT14_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)	327	Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(3)|large_intestine(10)|liver(1)|lung(21)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)	43	Acute lymphoblastic leukemia(172;0.155)					TCGGCTGCAGGGGACGATCTC	0.567000													24	35					7.92952e-12	5.33177e-10	7.16444e-05	1	0
VPS13A	23230	broad.mit.edu	37	9	79898509	79898509	+	Silent	SNP	C	C	T			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr9:79898509C>T	ENST00000360280.3	+	31	3542	c.3282C>T	c.(3280-3282)aaC>aaT	p.N1094N	VPS13A_ENST00000376636.3_Silent_p.N1055N|VPS13A_ENST00000423463.2_3'UTR|VPS13A_ENST00000376634.4_Silent_p.N1094N|VPS13A_ENST00000357409.5_Silent_p.N1094N	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	1094					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						CTGAAATAAACGCAAAGCTAA	0.284000													5	5					0	0	1.23904e-05	0	0
KMT2A	4297	broad.mit.edu	37	11	118376241	118376241	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr11:118376241A>G	ENST00000534358.1	+	27	9657	c.9634A>G	c.(9634-9636)Acc>Gcc	p.T3212A	KMT2A_ENST00000389506.5_Missense_Mutation_p.T3209A|KMT2A_ENST00000354520.4_Missense_Mutation_p.T3171A	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		AGACCTCAGTACCACAGTAGC	0.488000													27	10					0	0	7.16444e-05	0	0
LRRC37A16P	651250	broad.mit.edu	37	17	66130838	66130838	+	RNA	SNP	G	G	A			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr17:66130838G>A	ENST00000590019.1	-	0	298																											CTGGTCTAGGGGCGGCATGCT	0.577000													5	11					0	0	1.23904e-05	0	0
CRTAC1	55118	broad.mit.edu	37	10	99683047	99683047	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr10:99683047G>A	ENST00000370597.3	-	4	887	c.532C>T	c.(532-534)Cgc>Tgc	p.R178C	CRTAC1_ENST00000370591.2_Missense_Mutation_p.R178C|CRTAC1_ENST00000298819.4_Missense_Mutation_p.R178C	NM_018058.6	NP_060528.3	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1	178						proteinaceous extracellular matrix	calcium ion binding	p.R178C(1)		autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(6)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	35		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		GCCACAGAGCGTCCGGCAAAG	0.592000													7	54					0	0	0.000274275	0	0
HCAR2	338442	broad.mit.edu	37	12	123187358	123187358	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr12:123187358A>T	ENST00000328880.5	-	1	532	c.473T>A	c.(472-474)cTg>cAg	p.L158Q	HCAR1_ENST00000356987.2_Intron|RP11-324E6.6_ENST00000543611.1_lincRNA	NM_177551.3	NP_808219.1	Q8TDS4	HCAR2_HUMAN	hydroxycarboxylic acid receptor 2	158					negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	15					Mepenzolate(DB04843)|Niacin(DB00627)	GTGGACTGTCAGGCCAATAGT	0.547000													20	83					0	0	0.000229342	0	0
KIAA1045	23349	broad.mit.edu	37	9	34977182	34977182	+	Silent	SNP	C	C	A			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr9:34977182C>A	ENST00000242315.3	+	6	1034	c.952C>A	c.(952-954)Cgg>Agg	p.R318R	KIAA1045_ENST00000544237.1_Silent_p.R318R|KIAA1045_ENST00000476115.2_3'UTR	NM_015297.1	NP_056112.1	Q9UPV7	K1045_HUMAN	KIAA1045	318							calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			LUSC - Lung squamous cell carcinoma(32;0.00575)			AGAGTGCCGCCGGGCCCAGCA	0.637000													24	47					2.41591e-17	1.69611e-15	9.22233e-05	1	0
RLIM	51132	broad.mit.edu	37	X	73811749	73811749	+	Silent	SNP	G	G	C			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chrX:73811749G>C	ENST00000332687.6	-	4	1619	c.1401C>G	c.(1399-1401)tcC>tcG	p.S467S	RLIM_ENST00000349225.2_Silent_p.S467S	NM_016120.3	NP_057204.2	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	467	Poly-Ser.|Ser-rich.				random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						aactggaactggaactcgaac	0.468000													3	20					0	0	6.4e-05	0	0
PDC	5132	broad.mit.edu	37	1	186413523	186413523	+	Missense_Mutation	SNP	C	C	A			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr1:186413523C>A	ENST00000391997.2	-	4	416	c.329G>T	c.(328-330)aGa>aTa	p.R110I	PDC_ENST00000497198.1_Missense_Mutation_p.R58I|PDC_ENST00000456239.2_Missense_Mutation_p.R58I|PDC_ENST00000340129.5_Missense_Mutation_p.R110I	NM_002597.4	NP_002588.3	P20941	PHOS_HUMAN	phosducin	110					G-protein coupled receptor protein signaling pathway|phototransduction|visual perception	actin cytoskeleton|cytosol|nucleus|photoreceptor inner segment|photoreceptor outer segment	phospholipase inhibitor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)|prostate(1)|skin(1)	7		Breast(1374;1.53e-05)		KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.0129)		AAACCCATATCTAGGCCCAAA	0.383000													38	13					8.20599e-20	6.02698e-18	0.000106405	1	0
TAS2R43	259289	broad.mit.edu	37	12	11244482	11244482	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr12:11244482A>G	ENST00000531678.1	-	1	430	c.347T>C	c.(346-348)tTt>tCt	p.F116S	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_176884.2	NP_795365.2	P59537	T2R43_HUMAN	taste receptor, type 2, member 43	116					detection of chemical stimulus involved in sensory perception of bitter taste	cilium membrane|motile cilium	bitter taste receptor activity			endometrium(1)|ovary(1)|prostate(2)|urinary_tract(1)	5			OV - Ovarian serous cystadenocarcinoma(49;0.0344)	BRCA - Breast invasive adenocarcinoma(232;0.196)		AAGAAAAATAAAGTTGGAGAA	0.378000													3	30					0	0	6.4e-05	0	0
SLC17A7	57030	broad.mit.edu	37	19	49933928	49933928	+	Missense_Mutation	SNP	C	C	T	rs145455204		TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr19:49933928C>T	ENST00000221485.3	-	12	1702	c.1531G>A	c.(1531-1533)Gtt>Att	p.V511I	SLC17A7_ENST00000600601.1_Missense_Mutation_p.V444I|SLC17A7_ENST00000543531.1_Missense_Mutation_p.V499I	NM_020309.3	NP_064705.1	Q9P2U7	VGLU1_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 7	511					glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(7)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	26		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		TCATGGCCAACGAAGCCACAC	0.632000													44	13					0	0	0.000125731	0	0
MET	4233	broad.mit.edu	37	7	116339558	116339558	+	Silent	SNP	C	C	G			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr7:116339558C>G	ENST00000397752.3	+	2	620	c.420C>G	c.(418-420)acC>acG	p.T140T	MET_ENST00000436117.2_Silent_p.T140T|MET_ENST00000318493.6_Silent_p.T140T	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	140	Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			ACAGAGGGACCTGCCAGCGAC	0.488000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				19	34					0	0	9.7654e-05	0	0
CD70	970	broad.mit.edu	37	19	6586403	6586403	+	Silent	SNP	G	G	A			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr19:6586403G>A	ENST00000245903.3	-	3	359	c.210C>T	c.(208-210)gaC>gaT	p.D70D	CD70_ENST00000423145.3_Silent_p.D70D	NM_001252.3	NP_001243.1	P32970	CD70_HUMAN	CD70 molecule	70					cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to membrane of membrane fraction|integral to plasma membrane	cytokine activity|protease binding|tumor necrosis factor receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|skin(1)	11						ATAGCCTGGGGTCCTGCTGAG	0.582000													8	14					0	0	0.000157383	0	0
NCAPH2	29781	broad.mit.edu	37	22	50961607	50961607	+	Silent	SNP	G	G	A			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr22:50961607G>A	ENST00000395701.3	+	19	1783	c.1689G>A	c.(1687-1689)ctG>ctA	p.L563L	NCAPH2_ENST00000299821.11_Intron|NCAPH2_ENST00000420993.2_Intron			Q6IBW4	CNDH2_HUMAN	non-SMC condensin II complex, subunit H2	0					chromosome condensation	chromosome|nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(3)|lung(10)|ovary(1)|prostate(2)|skin(3)|stomach(1)	24		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		TGAGTAGCCTGGGATACGTGG	0.637000													6	21					0	0	8.12818e-05	0	0
NCOR1	9611	broad.mit.edu	37	17	16052809	16052809	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr17:16052809G>A	ENST00000268712.3	-	9	1122	c.865C>T	c.(865-867)Ctc>Ttc	p.L289F	NCOR1_ENST00000395851.1_Missense_Mutation_p.L289F|NCOR1_ENST00000395848.1_Missense_Mutation_p.L180F	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	289	Interaction with SIN3A/B.|Interaction with ZBTB33 and HEXIM1.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		AATAAAATGAGTTTTTTCCTC	0.313000													27	114					0	0	0.000184323	0	0
LRRC10	376132	broad.mit.edu	37	12	70004410	70004410	+	Missense_Mutation	SNP	T	T	A			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr12:70004410T>A	ENST00000361484.3	-	1	532	c.209A>T	c.(208-210)gAg>gTg	p.E70V		NM_201550.2	NP_963844.2	Q5BKY1	LRC10_HUMAN	leucine rich repeat containing 10	70						nucleus				large_intestine(2)|lung(6)	8	all_cancers(2;2.83e-105)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;1.98e-18)|GBM - Glioblastoma multiforme(2;7.43e-12)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			CTGCCCCAGCTCCGGAGGCAG	0.582000													9	267					0	0	3.86212e-05	0	0
SON	6651	broad.mit.edu	37	21	34923346	34923346	+	Silent	SNP	T	T	C			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr21:34923346T>C	ENST00000356577.4	+	3	2284	c.1809T>C	c.(1807-1809)gcT>gcC	p.A603A	SON_ENST00000290239.6_Silent_p.A603A|SON_ENST00000300278.4_Silent_p.A603A|SON_ENST00000381679.4_Silent_p.A603A|SON_ENST00000381692.2_Intron	NM_138927.1	NP_620305.1	P18583	SON_HUMAN	SON DNA binding protein	603					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						TCATGGCAGCTGGGGCACTGG	0.657000													29	58					0	0	8.91981e-05	0	0
ZBTB16	7704	broad.mit.edu	37	11	113934445	113934445	+	Silent	SNP	G	G	T			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr11:113934445G>T	ENST00000335953.4	+	2	803	c.423G>T	c.(421-423)ggG>ggT	p.G141G	ZBTB16_ENST00000392996.2_Silent_p.G141G	NM_006006.4	NP_005997.2	Q05516	ZBT16_HUMAN	zinc finger and BTB domain containing 16	141					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|large_intestine(2)|skin(1)|upper_aerodigestive_tract(2)	6		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		CCGATGGCGGGGCCGAGGAAG	0.582000													53	958					1.00221e-16	6.93415e-15	0.000147903	1	0
KRTAP4-7	100132476	broad.mit.edu	37	17	39240627	39240627	+	Missense_Mutation	SNP	T	T	C	rs139671425	by1000genomes	TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr17:39240627T>C	ENST00000391417.4	+	1	169	c.169T>C	c.(169-171)Tct>Cct	p.S57P		NM_033061.3	NP_149050.3			keratin associated protein 4-7									p.S57P(4)		NS(1)|endometrium(3)|kidney(1)|lung(1)|prostate(2)|urinary_tract(1)	9						GTGCTGCCAGTCTGTGTGCTG	0.667000													9	51					0	0	3.45872e-05	0	0
LRRC32	2615	broad.mit.edu	37	11	76371968	76371968	+	Silent	SNP	T	T	C			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr11:76371968T>C	ENST00000407242.2	-	3	911	c.669A>G	c.(667-669)ctA>ctG	p.L223L	LRRC32_ENST00000464145.1_Intron|LRRC32_ENST00000404995.1_Silent_p.L223L|LRRC32_ENST00000260061.5_Silent_p.L223L|AP001189.4_ENST00000447519.1_RNA	NM_005512.2	NP_005503.1	Q14392	LRC32_HUMAN	leucine rich repeat containing 32	223			L -> V (in dbSNP:rs35033061).			integral to plasma membrane				endometrium(1)|large_intestine(3)|lung(26)|upper_aerodigestive_tract(1)	31						AGCTCAGGTCTAGCACCCGCA	0.622000													40	638					0	0	5.1965e-05	0	0
TTI1	9675	broad.mit.edu	37	20	36634691	36634691	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr20:36634691G>T	ENST00000373448.2	-	4	2649	c.2411C>A	c.(2410-2412)aCc>aAc	p.T804N	TTI1_ENST00000373447.3_Missense_Mutation_p.T804N|TTI1_ENST00000449821.1_Missense_Mutation_p.T804N	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	804							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						TTCAGCTGTGGTGGTGCTCTT	0.448000													36	162					9.8876e-21	7.37553e-19	0.000159656	1	0
PPTC7	160760	broad.mit.edu	37	12	110977692	110977692	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr12:110977692C>T	ENST00000354300.3	-	4	949	c.661G>A	c.(661-663)Gca>Aca	p.A221T		NM_139283.1	NP_644812.1	Q8NI37	PPTC7_HUMAN	PTC7 protein phosphatase homolog (S. cerevisiae)	221	PP2C-like.						metal ion binding|phosphoprotein phosphatase activity			endometrium(1)|large_intestine(2)|lung(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	9						CCATCTGTTGCCGTCAGGATA	0.448000													9	57					0	0	2.17888e-05	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8662006	8662006	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr19:8662006T>C	ENST00000270328.4	-	7	1171	c.905A>G	c.(904-906)gAg>gGg	p.E302G	ADAMTS10_ENST00000597188.1_Missense_Mutation_p.E302G			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	302	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						GTGGGTGATCTCCAGAGTGGG	0.592000													28	79					0	0	4.66903e-05	0	0
DNAH9	1770	broad.mit.edu	37	17	11572800	11572800	+	Silent	SNP	G	G	A			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr17:11572800G>A	ENST00000262442.3	+	17	3110	c.3042G>A	c.(3040-3042)tcG>tcA	p.S1014S	DNAH9_ENST00000454412.2_Silent_p.S1014S	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1014	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GCCAGTATTCGTACCTCTATG	0.522000													6	46					0	0	0.000157383	0	0
MUC4	4585	broad.mit.edu	37	3	195515747	195515747	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr3:195515747C>T	ENST00000463781.3	-	2	3163	c.2704G>A	c.(2704-2706)Gcc>Acc	p.A902T	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.A902T	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	907	Ser-rich.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.A902T(2)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAAATGGCGGCTGTCTCCTGA	0.607000													11	20					0	0	6.40141e-05	0	0
ACBD4	79777	broad.mit.edu	37	17	43215194	43215194	+	Missense_Mutation	SNP	G	G	C			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr17:43215194G>C	ENST00000431281.1	+	9	1077	c.608G>C	c.(607-609)aGc>aCc	p.S203T	ACBD4_ENST00000592162.1_Missense_Mutation_p.E190D|ACBD4_ENST00000591859.1_Missense_Mutation_p.S203T|ACBD4_ENST00000591136.1_3'UTR|ACBD4_ENST00000321854.8_Missense_Mutation_p.E190D|ACBD4_ENST00000376955.4_Missense_Mutation_p.E190D|ACBD4_ENST00000398322.3_Missense_Mutation_p.E190D|ACBD4_ENST00000586346.1_Missense_Mutation_p.S203T	NM_001135704.1	NP_001129176.1	Q8NC06	ACBD4_HUMAN	acyl-CoA binding domain containing 4	187							fatty-acyl-CoA binding			kidney(1)|lung(3)|ovary(1)	5						TGGAGCCTGAGCTGGTGAGCC	0.597000													28	173					0	0	0.000279167	0	0
NFAM1	150372	broad.mit.edu	37	22	42805442	42805442	+	Splice_Site	SNP	T	T	A			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr22:42805442T>A	ENST00000329021.5	-	3	600	c.564_splice	c.e3+1	p.K188_splice		NM_145912.5	NP_666017.1	Q8NET5	NFAM1_HUMAN	NFAT activating protein with ITAM motif 1	188					B cell differentiation|inflammatory response|intracellular signal transduction|positive regulation of B cell receptor signaling pathway|positive regulation of cytokine production|positive regulation of sequence-specific DNA binding transcription factor activity	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			large_intestine(1)|lung(3)	4						ATCCCGTACCTTGTTCCAGAG	0.667000													7	125					0	0	0.000274275	0	0
KCNMA1	3778	broad.mit.edu	37	10	78872169	78872169	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr10:78872169T>C	ENST00000286627.5	-	7	1868	c.916A>G	c.(916-918)Ata>Gta	p.I306V	KCNMA1_ENST00000404771.3_Missense_Mutation_p.I306V|KCNMA1_ENST00000372440.1_Missense_Mutation_p.I306V|KCNMA1_ENST00000406533.3_Missense_Mutation_p.I306V|KCNMA1_ENST00000286628.8_Missense_Mutation_p.I306V|KCNMA1_ENST00000372443.1_Missense_Mutation_p.I306V|KCNMA1_ENST00000404857.1_Missense_Mutation_p.I306V|KCNMA1_ENST00000354353.5_Missense_Mutation_p.I306V	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	306					cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	CTGATAAATATGGAGAGCAGA	0.522000											OREG0020286	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	5					0	0	0.000151284	0	0
HEATR4	399671	broad.mit.edu	37	14	73985814	73985814	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr14:73985814C>A	ENST00000553558.1	-	5	1444	c.1123G>T	c.(1123-1125)Gaa>Taa	p.E375*	RP3-414A15.11_ENST00000553394.1_RNA|HEATR4_ENST00000334988.2_Nonsense_Mutation_p.E375*|HEATR4_ENST00000560393.1_Nonsense_Mutation_p.E328*	NM_001220484.1	NP_001207413.1			HEAT repeat containing 4											breast(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		TTTAGGTTTTCCAGGACAATC	0.453000													21	45					1.55795e-14	1.06252e-12	0.000229342	1	0
MYO5B	4645	broad.mit.edu	37	18	47363917	47363917	+	Missense_Mutation	SNP	A	A	G	rs138128932	by1000genomes	TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr18:47363917A>G	ENST00000285039.7	-	37	5407	c.5108T>C	c.(5107-5109)gTc>gCc	p.V1703A	MYO5B_ENST00000592688.1_Missense_Mutation_p.V273A|MYO5B_ENST00000324581.6_Missense_Mutation_p.V818A|RP11-886H22.1_ENST00000590532.2_Missense_Mutation_p.V26A|SCARNA17_ENST00000589499.1_RNA	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1703	Dilute.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity	p.V1703A(5)		NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		CCAAGAGCAGACGTCCTTCCG	0.527000													5	32					0	0	8.12818e-05	0	0
DENND1C	79958	broad.mit.edu	37	19	6477464	6477464	+	Silent	SNP	G	G	C			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr19:6477464G>C	ENST00000381480.2	-	7	484	c.372C>G	c.(370-372)acC>acG	p.T124T	DENND1C_ENST00000543576.1_Silent_p.T80T|DENND1C_ENST00000591030.1_5'UTR	NM_024898.2	NP_079174.2	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	124	DENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(3)|large_intestine(1)|lung(3)	10						CCTCTGCCTCGGTGACCTGGG	0.617000													5	20					0	0	8.12818e-05	0	0
NACA	4666	broad.mit.edu	37	12	57113369	57113369	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr12:57113369G>A	ENST00000454682.1	-	3	2226	c.1945C>T	c.(1945-1947)Cct>Tct	p.P649S	NACA_ENST00000552540.1_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000550952.1_Missense_Mutation_p.P606S|NACA_ENST00000551793.1_Intron|NACA_ENST00000548563.1_Intron|NACA_ENST00000356769.3_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						CTTTCCAAAGGAAATGCAGCC	0.512000			T	BCL6	NHL								9	206					0	0	0.000274275	0	0
DNM2	1785	broad.mit.edu	37	19	10939755	10939755	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr19:10939755C>T	ENST00000314646.5	+	19	2266	c.2102C>T	c.(2101-2103)tCc>tTc	p.S701F	DNM2_ENST00000389253.4_Missense_Mutation_p.S701F|DNM2_ENST00000359692.6_Missense_Mutation_p.S697F|DNM2_ENST00000355667.6_Missense_Mutation_p.S701F|DNM2_ENST00000585892.1_Missense_Mutation_p.S701F|DNM2_ENST00000408974.4_Missense_Mutation_p.S697F			P50570	DYN2_HUMAN	dynamin 2	701	GED.				G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	42			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			TACCTATACTCCTCGGCAGAC	0.632000			"""F, N, Splice, Mis, O"""		ETP ALL								6	27					0	0	8.12818e-05	0	0
JUP	3728	broad.mit.edu	37	17	39913672	39913672	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr17:39913672C>T	ENST00000393931.3	-	12	2159	c.2041G>A	c.(2041-2043)Gag>Aag	p.E681K	JUP_ENST00000310706.5_Missense_Mutation_p.E681K|JUP_ENST00000393930.1_Missense_Mutation_p.E681K|JUP_ENST00000540235.1_Intron	NM_002230.2	NP_002221.1	P14923	PLAK_HUMAN	junction plakoglobin	681					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	23		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		CTCACAGCCTCCCAGGCAGCC	0.572000													32	91					0	0	0.000270559	0	0
NNMT	4837	broad.mit.edu	37	11	114182786	114182786	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr11:114182786G>T	ENST00000535401.1	+	5	646	c.382G>T	c.(382-384)Gag>Tag	p.E128*	NNMT_ENST00000542647.1_5'UTR|NNMT_ENST00000541754.1_5'UTR|RP11-64D24.2_ENST00000544925.1_RNA|NNMT_ENST00000545255.1_5'UTR|NNMT_ENST00000299964.3_Nonsense_Mutation_p.E128*			P40261	NNMT_HUMAN	nicotinamide N-methyltransferase	128					xenobiotic metabolic process	cytosol	nicotinamide N-methyltransferase activity|pyridine N-methyltransferase activity			kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(61;4.83e-16)|all_epithelial(67;7.28e-09)|all_hematologic(158;0.000135)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.79e-06)|Epithelial(105;1.32e-05)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.128)	Niacin(DB00627)	TCCAGAGAAGGAGGAGAAGTT	0.547000													59	32					2.53126e-37	1.94907e-35	0.000147903	1	0
HDAC5	10014	broad.mit.edu	37	17	42161941	42161941	+	Missense_Mutation	SNP	C	C	G			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr17:42161941C>G	ENST00000225983.6	-	16	2613	c.2290G>C	c.(2290-2292)Gac>Cac	p.D764H	HDAC5_ENST00000586802.1_Missense_Mutation_p.D763H|HDAC5_ENST00000393622.2_Missense_Mutation_p.D763H|HDAC5_ENST00000336057.5_Intron			Q9UQL6	HDAC5_HUMAN	histone deacetylase 5	763	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|chromatin remodeling|chromatin silencing|inflammatory response|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	21		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.118)		TTCTTGCTGTCTAGCTTCTGC	0.592000											OREG0024450	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	63					0	0	0.000175454	0	0
SHMT2	6472	broad.mit.edu	37	12	57626583	57626583	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr12:57626583G>A	ENST00000328923.3	+	7	1266	c.814G>A	c.(814-816)Gac>Aac	p.D272N	SHMT2_ENST00000393827.4_Missense_Mutation_p.D176N|SHMT2_ENST00000449049.3_Missense_Mutation_p.D251N|SHMT2_ENST00000414700.3_Missense_Mutation_p.D251N|SHMT2_ENST00000557487.1_Missense_Mutation_p.D262N|SHMT2_ENST00000553474.1_Missense_Mutation_p.D251N	NM_001166356.1|NM_005412.5	NP_001159828.1|NP_005403.2	P34897	GLYM_HUMAN	serine hydroxymethyltransferase 2 (mitochondrial)	272						microtubule cytoskeleton|mitochondrial nucleoid	glycine hydroxymethyltransferase activity|methyltransferase activity			breast(1)|central_nervous_system(1)|large_intestine(4)|liver(2)|lung(3)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	15					Glycine(DB00145)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	CAAGCACGCGGACATCGTCAC	0.602000													14	352					0	0	2.31682e-05	0	0
DSCAM	1826	broad.mit.edu	37	21	41450683	41450683	+	Missense_Mutation	SNP	T	T	A			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr21:41450683T>A	ENST00000400454.1	-	26	5119	c.4642A>T	c.(4642-4644)Atg>Ttg	p.M1548L		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1548	Fibronectin type-III 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CACACCCGCATCTGCAGCTCA	0.582000													12	27					0	0	0.000151284	0	0
TAS2R38	5726	broad.mit.edu	37	7	141672894	141672894	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr7:141672894T>C	ENST00000547270.1	-	1	679	c.596A>G	c.(595-597)tAt>tGt	p.Y199C		NM_176817.4	NP_789787.4	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	199					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			NS(2)|breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)|skin(1)|stomach(1)	21	Melanoma(164;0.0171)					AGACCACAGATAGCAGAAGAG	0.423000													11	14					0	0	6.40141e-05	0	0
NPTX2	4885	broad.mit.edu	37	7	98256538	98256538	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr7:98256538C>T	ENST00000265634.3	+	4	1115	c.950C>T	c.(949-951)aCg>aTg	p.T317M		NM_002523.2	NP_002514.1	P47972	NPTX2_HUMAN	neuronal pentraxin II	317	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			GTCACCTGGACGACACGGGAT	0.642000													10	63					0	0	6.40141e-05	0	0
LRIG3	121227	broad.mit.edu	37	12	59268354	59268354	+	Splice_Site	SNP	C	C	T			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr12:59268354C>T	ENST00000320743.3	-	17	2983	c.2695_splice	c.e17-1	p.G899_splice	LRIG3_ENST00000379141.4_Splice_Site_p.G839_splice	NM_153377.4	NP_700356.2	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like domains 3	899						integral to membrane			LRIG3/ROS1(2)	breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(12)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48			GBM - Glioblastoma multiforme(1;1.17e-18)			TATGGCAGGTCCCTTTGAAAC	0.403000			T	ROS1	NSCLC								87	150					0	0	0.000147903	0	0
NCOR1	9611	broad.mit.edu	37	17	15974803	15974803	+	Missense_Mutation	SNP	C	C	G			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr17:15974803C>G	ENST00000268712.3	-	30	4329	c.4072G>C	c.(4072-4074)Gat>Cat	p.D1358H	NCOR1_ENST00000395851.1_Missense_Mutation_p.D1374H|NCOR1_ENST00000395857.3_Intron	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	1358	Interaction with ETO.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GTTAAAATATCTTGCCTTGGA	0.443000													18	77					0	0	5.01169e-05	0	0
MAP7D2	256714	broad.mit.edu	37	X	20134870	20134870	+	Missense_Mutation	SNP	T	T	G			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chrX:20134870T>G	ENST00000379651.3	-	1	146	c.128A>C	c.(127-129)cAa>cCa	p.Q43P	MAP7D2_ENST00000379643.5_Missense_Mutation_p.Q43P|MAP7D2_ENST00000443379.3_Missense_Mutation_p.Q43P	NM_152780.3	NP_689993.2	Q96T17	MA7D2_HUMAN	MAP7 domain containing 2	43										NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	37						GATAATACCTTGAGGCCGGTA	0.711000													13	35					0	0	5.01169e-05	0	0
RASSF8	11228	broad.mit.edu	37	12	26217544	26217544	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr12:26217544G>A	ENST00000405154.2	+	3	416	c.217G>A	c.(217-219)Gtg>Atg	p.V73M	RASSF8_ENST00000541490.1_Missense_Mutation_p.V73M|RASSF8_ENST00000381352.3_Missense_Mutation_p.V73M|RASSF8_ENST00000542865.1_Missense_Mutation_p.V73M|RASSF8_ENST00000282884.9_Missense_Mutation_p.V73M	NM_001164748.1	NP_001158220.1	Q8NHQ8	RASF8_HUMAN	Ras association (RalGDS/AF-6) domain family (N-terminal) member 8	73	Ras-associating.				signal transduction					cervix(2)|endometrium(1)|large_intestine(6)|lung(15)|urinary_tract(1)	25	Colorectal(261;0.0847)					TGCTAGTGATGTGCAGCTCAT	0.453000													14	27					0	0	3.45872e-05	0	0
GLRA4	441509	broad.mit.edu	37	X	102968473	102968473	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chrX:102968473C>T	ENST00000372617.4	-	8	1478	c.1058G>A	c.(1057-1059)cGa>cAa	p.R353Q	TMEM31_ENST00000319560.6_Intron	NM_001024452.2	NP_001019623.2	Q5JXX5	GLRA4_HUMAN	glycine receptor, alpha 4	353						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	21						CTGCCTTCTTCGAAGTCGTAT	0.517000													35	32					0	0	0.000159656	0	0
PRG4	10216	broad.mit.edu	37	1	186276689	186276689	+	Missense_Mutation	SNP	C	C	G			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr1:186276689C>G	ENST00000445192.2	+	7	1883	c.1838C>G	c.(1837-1839)cCc>cGc	p.P613R	PRG4_ENST00000367485.4_Missense_Mutation_p.P520R|PRG4_ENST00000367486.3_Missense_Mutation_p.P570R|PRG4_ENST00000367484.3_Intron|PRG4_ENST00000367483.4_Missense_Mutation_p.P572R	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	613	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CCAACTACCCCCAAGGAGACT	0.662000													41	18					0	0	0.000147903	0	0
CASS4	57091	broad.mit.edu	37	20	55033678	55033678	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr20:55033678G>T	ENST00000371336.3	+	6	2437	c.2236G>T	c.(2236-2238)Gac>Tac	p.D746Y	CASS4_ENST00000434344.1_Missense_Mutation_p.D309Y|CASS4_ENST00000360314.3_Missense_Mutation_p.D746Y	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	746					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						CCTGCTCAAGGACGTAGCGCT	0.652000													12	21					2.27111e-07	1.50587e-05	0.00010058	1	0
KBTBD12	166348	broad.mit.edu	37	3	127682078	127682078	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr3:127682078delC	ENST00000405109.1	+	5	2006	c.1539delC	c.(1537-1539)tgfs	p.C513fs	KBTBD12_ENST00000492025.1_3'UTR|KBTBD12_ENST00000405256.1_Frame_Shift_Del_p.C513fs|KBTBD12_ENST00000343941.4_Frame_Shift_Del_p.C88fs|KBTBD12_ENST00000407609.3_Frame_Shift_Del_p.C120fs			Q3ZCT8	KBTBC_HUMAN	kelch repeat and BTB (POZ) domain containing 12	513										endometrium(1)|large_intestine(6)|lung(5)|ovary(1)	13						TTCGAAAATGCCTTGACGTGG	0.522													2	4	---	---	---	---					
NAALADL2	254827	broad.mit.edu	37	3	175473198	175473198	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr3:175473198delT	ENST00000454872.1	+	13	2309	c.2181delT	c.(2179-2181)ggfs	p.G727fs		NM_207015.2	NP_996898.2	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 2	727					proteolysis	integral to membrane	peptidase activity			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(20)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	49	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		CACCACCAGGTTTTTATAGGT	0.393													2	4	---	---	---	---					
POLE	5426	broad.mit.edu	37	12	133220099	133220100	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr12:133220099_133220100delCA	ENST00000320574.5	-	34	4380_4381	c.4337_4338delTG	c.(4336-4338)gfs	p.V1447fs	POLE_ENST00000535270.1_Frame_Shift_Del_p.V1420fs	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	1447					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GTTTATTGACCACACACACACA	0.604								DNA polymerases (catalytic subunits)					10	427	---	---	---	---					
SPRED1	161742	broad.mit.edu	37	15	38643678	38643679	+	Frame_Shift_Ins	INS	-	-	A			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr15:38643678_38643679insA	ENST00000299084.4	+	7	2008_2009	c.1148_1149insA	c.(1147-1149)tgafs	p.*383fs		NM_152594.2	NP_689807.1	Q7Z699	SPRE1_HUMAN	sprouty-related, EVH1 domain containing 1	383	SPR.				inactivation of MAPK activity|multicellular organismal development	caveola|nucleus	stem cell factor receptor binding			kidney(6)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(109;4.88e-13)|all_epithelial(112;1.83e-11)|Lung NSC(122;2.21e-09)|all_lung(180;4.64e-08)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(113;2.41e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		ATGTCAGACTCAGAGGGAGATT	0.436									Legius syndrome				13	1	---	---	---	---					
PIGB	9488	broad.mit.edu	37	15	55631503	55631503	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr15:55631503delT	ENST00000164305.5	+	7	1124	c.833delT	c.(832-834)atfs	p.I278fs	PIGB_ENST00000539642.1_Frame_Shift_Del_p.I83fs	NM_004855.4	NP_004846.4	Q92521	PIGB_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class B	278					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	integral to membrane|intrinsic to endoplasmic reticulum membrane	glycolipid mannosyltransferase activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	11				all cancers(107;0.0255)		ATTGATCGTATTTTTTTTGGC	0.284													3	6	---	---	---	---					
CDC27	996	broad.mit.edu	37	17	45247389	45247389	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GN-A26D-06A-11D-A19A-08	TCGA-GN-A26D-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fc0661b-2941-4418-99f2-8a1e8caa6201	61aaf08e-dfe6-4ccc-9a71-7626e3c8f6fa	g.chr17:45247389delT	ENST00000066544.3	-	4	364	c.271delA	c.(271-273)tcfs	p.I91fs	CDC27_ENST00000446365.2_Frame_Shift_Del_p.I30fs|CDC27_ENST00000531206.1_Frame_Shift_Del_p.I91fs|CDC27_ENST00000527547.1_Frame_Shift_Del_p.I91fs|CDC27_ENST00000528748.1_5'UTR|RP5-867C24.5_ENST00000572193.1_RNA	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	91					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding	p.I91fs*54(1)		NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						CCAGATAAGATTTGTTCCCCT	0.323													13	221	---	---	---	---