Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TARBP1	6894	broad.mit.edu	37	1	234565942	234565942	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:234565942G>A	ENST00000040877.1	-	15	2499	c.2500C>T	c.(2500-2502)Cat>Tat	p.H834Y		NM_005646.3	NP_005637.3	Q13395	TARB1_HUMAN	TAR (HIV-1) RNA binding protein 1	834					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(7)|large_intestine(6)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	55	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			GGCCCAGCATGGAGAGAGTCC	0.557000													40	64					0	0	0.000191422	0	0
DSCAM	1826	broad.mit.edu	37	21	41465790	41465790	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr21:41465790C>T	ENST00000400454.1	-	21	4185	c.3708G>A	c.(3706-3708)gaG>gaA	p.E1236E		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1236	Fibronectin type-III 4.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AGGCCTCAAACTCGCTGATCA	0.458000													12	31					0	0	0.000219431	0	0
LILRA2	11027	broad.mit.edu	37	19	55086450	55086450	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr19:55086450C>T	ENST00000251377.3	+	5	738	c.605C>T	c.(604-606)tCt>tTt	p.S202F	LILRB1_ENST00000418536.2_Intron|LILRA2_ENST00000251376.3_Missense_Mutation_p.S202F|LILRA2_ENST00000391737.1_Missense_Mutation_p.S190F|LILRB1_ENST00000396321.2_Intron|LILRB1_ENST00000448689.1_Intron|LILRA2_ENST00000391738.3_Missense_Mutation_p.S202F					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		GACTCGAACTCTCCCTATGTG	0.577000													20	115					0	0	0.000295444	0	0
FBXO46	23403	broad.mit.edu	37	19	46215078	46215078	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr19:46215078C>T	ENST00000317683.3	-	2	1809	c.1676G>A	c.(1675-1677)gGa>gAa	p.G559E		NM_001080469.1	NP_001073938.1	Q6PJ61	FBX46_HUMAN	F-box protein 46	559							protein binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(2)|skin(1)	15		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00568)|GBM - Glioblastoma multiforme(486;0.0844)|Epithelial(262;0.201)		GTAGGAACGTCCGTAAGGCAG	0.642000													17	15					0	0	0.000132079	0	0
ENOX1	55068	broad.mit.edu	37	13	43843642	43843642	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr13:43843642G>A	ENST00000261488.6	-	13	2095	c.1518C>T	c.(1516-1518)tcC>tcT	p.S506S	ENOX1_ENST00000412891.1_Silent_p.S506S	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	506					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		CTTGTGTATGGGACTGCTCTT	0.398000													49	116					0	0	0.000781405	0	0
IGHV3-43	28426	broad.mit.edu	37	14	106926190	106926190	+	RNA	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr14:106926190C>T	ENST00000434710.1	-	0	431																											CACTGTGTATCTTTTGCACAG	0.532000													11	122					0	0	0.000586117	0	0
TXNDC2	84203	broad.mit.edu	37	18	9886650	9886650	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr18:9886650C>T	ENST00000306084.6	+	2	373	c.174C>T	c.(172-174)gcC>gcT	p.A58A	TXNDC2_ENST00000536353.2_5'UTR|TXNDC2_ENST00000357775.4_5'UTR|TXNDC2_ENST00000426718.3_3'UTR|TXNDC2_ENST00000584255.1_3'UTR	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	58					cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						TGGAAATAGCCCAGGCCAAAG	0.478000													22	41					0	0	0.000227799	0	0
NAALAD2	10003	broad.mit.edu	37	11	89891372	89891372	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr11:89891372C>T	ENST00000534061.1	+	7	1086	c.856C>T	c.(856-858)Ccc>Tcc	p.P286S	NAALAD2_ENST00000375944.3_Intron|NAALAD2_ENST00000525171.1_Intron|NAALAD2_ENST00000321955.4_Missense_Mutation_p.P286S	NM_005467.3	NP_005458.1	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	286	NAALADase.				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(32)|pancreas(1)|prostate(3)|skin(5)|stomach(2)	59		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				ACCTGTACATCCCATTGGATA	0.299000													33	112					0	0	0.000814825	0	0
PLXNB3	5365	broad.mit.edu	37	X	153043033	153043033	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chrX:153043033G>A	ENST00000538966.1	+	32	5491	c.5220G>A	c.(5218-5220)gtG>gtA	p.V1740V	PLXNB3_ENST00000485980.1_3'UTR|SRPK3_ENST00000489426.1_5'UTR|PLXNB3_ENST00000538776.1_Silent_p.V1370V|PLXNB3_ENST00000361971.5_Silent_p.V1717V	NM_001163257.1	NP_001156729.1	Q9ULL4	PLXB3_HUMAN	plexin B3	1717					axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|endometrium(7)|large_intestine(2)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					TTCTCAGCGTGAACCGGCCCA	0.612000													6	53					0	0	3.59834e-05	0	0
GPC2	221914	broad.mit.edu	37	7	99769797	99769797	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:99769797G>A	ENST00000292377.2	-	6	1103	c.936C>T	c.(934-936)tcC>tcT	p.S312S	GPC2_ENST00000471050.1_5'UTR	NM_152742.1	NP_689955.1	Q8N158	GPC2_HUMAN	glypican 2	312						anchored to membrane|endoplasmic reticulum|extracellular space|plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(3)	18	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TCAGCTCAAAGGAAAAGGGGC	0.537000													8	52					0	0	0.000274275	0	0
POMGNT1	55624	broad.mit.edu	37	1	46657986	46657986	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:46657986C>T	ENST00000371992.1	-	16	2057	c.1407G>A	c.(1405-1407)ccG>ccA	p.P469P	POMGNT1_ENST00000485714.1_5'UTR|POMGNT1_ENST00000396420.3_3'UTR|POMGNT1_ENST00000371984.3_Silent_p.P469P|POMGNT1_ENST00000371986.3_Silent_p.P469P|POMGNT1_ENST00000535522.1_Silent_p.P447P	NM_001243766.1	NP_001230695.1	Q8WZA1	PMGT1_HUMAN	protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)	469					protein N-linked glycosylation|protein O-linked glycosylation	Golgi membrane|integral to membrane|microsome	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(166;0.155)					TTACCTTTTCCGGTGTAGGCC	0.572000													23	42					0	0	0.00047179	0	0
ACSF2	80221	broad.mit.edu	37	17	48539911	48539911	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr17:48539911T>C	ENST00000427954.2	+	7	875	c.832T>C	c.(832-834)Tcc>Ccc	p.S278P	ACSF2_ENST00000541920.1_Missense_Mutation_p.S93P|ACSF2_ENST00000502667.1_Missense_Mutation_p.S240P|ACSF2_ENST00000300441.4_Missense_Mutation_p.S253P|ACSF2_ENST00000504392.1_Missense_Mutation_p.S210P			Q96CM8	ACSF2_HUMAN	acyl-CoA synthetase family member 2	253					fatty acid metabolic process	mitochondrion	ATP binding|ligase activity			endometrium(7)|kidney(3)|large_intestine(1)|lung(1)|stomach(1)	13	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			GCAGTTCCTGTCCTGCCATGA	0.617000													7	48					0	0	0.000157383	0	0
NT5E	4907	broad.mit.edu	37	6	86180955	86180955	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr6:86180955G>A	ENST00000257770.3	+	3	612	c.562_splice	c.e3-1	p.G188_splice	NT5E_ENST00000369651.3_Splice_Site_p.G188_splice|NT5E_ENST00000369646.3_Splice_Site_p.G188_splice	NM_002526.3	NP_002517.1	P21589	5NTD_HUMAN	5'-nucleotidase, ecto (CD73)	188					DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)	tGTTCCTTAGGGACAAATTTA	0.254000													4	10					0	0	0.00024832	0	0
GPC5	2262	broad.mit.edu	37	13	92345598	92345598	+	Missense_Mutation	SNP	A	A	T	rs144683011	byFrequency	TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr13:92345598A>T	ENST00000377067.3	+	3	855	c.483A>T	c.(481-483)gaA>gaT	p.E161D		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	161						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				ATCCTGAAGAATTTGTAAACA	0.453000													26	76					0	0	0.000184323	0	0
GBP1	2633	broad.mit.edu	37	1	89522681	89522681	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:89522681C>T	ENST00000370473.4	-	7	1230	c.1011G>A	c.(1009-1011)caG>caA	p.Q337Q		NM_002053.2	NP_002044.2	P32455	GBP1_HUMAN	guanylate binding protein 1, interferon-inducible	337					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(7)|kidney(4)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	30		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		GGCCCATCTGCTGTTCATAGT	0.567000													5	71					0	0	3.59834e-05	0	0
RNF40	9810	broad.mit.edu	37	16	30783229	30783229	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr16:30783229C>T	ENST00000324685.6	+	18	3097	c.2662C>T	c.(2662-2664)Cag>Tag	p.Q888*	RNF40_ENST00000567365.1_3'UTR|RNF40_ENST00000563683.1_Nonsense_Mutation_p.Q848*|RNF40_ENST00000402121.3_Nonsense_Mutation_p.Q580*|RNF40_ENST00000357890.5_Nonsense_Mutation_p.Q788*	NM_001207033.1|NM_014771.3	NP_001193962.1|NP_055586.1	O75150	BRE1B_HUMAN	ring finger protein 40, E3 ubiquitin protein ligase	888					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)	30			Colorectal(24;0.198)			GCGGGAGATCCAGCCCTGCCT	0.647000													16	27					0	0	0.000308642	0	0
CABP2	51475	broad.mit.edu	37	11	67287292	67287292	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr11:67287292G>A	ENST00000294288.4	-	6	678	c.609C>T	c.(607-609)ctC>ctT	p.L203L	CABP2_ENST00000353903.5_Silent_p.L146L	NM_016366.2	NP_057450.2	Q9NPB3	CABP2_HUMAN	calcium binding protein 2	203	EF-hand 4.				signal transduction	Golgi apparatus|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			endometrium(2)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	9						CGTCCCCATTGAGGTCCACGT	0.652000													21	20					0	0	0.000720815	0	0
RNASE10	338879	broad.mit.edu	37	14	20979015	20979015	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr14:20979015G>A	ENST00000430083.1	+	2	873	c.469G>A	c.(469-471)Gag>Aag	p.E157K	RNASE10_ENST00000328444.5_Missense_Mutation_p.E129K			Q5GAN6	RNS10_HUMAN	ribonuclease, RNase A family, 10 (non-active)	129						extracellular region	nucleic acid binding|pancreatic ribonuclease activity	p.E129*(1)		endometrium(1)|large_intestine(2)|lung(8)|urinary_tract(1)	12	all_cancers(95;0.00123)		Epithelial(56;1.81e-07)|all cancers(55;1.86e-06)	GBM - Glioblastoma multiforme(265;0.022)|READ - Rectum adenocarcinoma(17;0.191)		CAAGATGAAGGAGCCCAGTCA	0.458000													11	13					0	0	0.00010058	0	0
DIP2A	23181	broad.mit.edu	37	21	47971610	47971610	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr21:47971610C>G	ENST00000318711.7	+	24	3089	c.2906C>G	c.(2905-2907)tCc>tGc	p.S969C	DIP2A_ENST00000427143.2_Missense_Mutation_p.S904C|DIP2A_ENST00000417564.2_Missense_Mutation_p.S968C|DIP2A_ENST00000400274.1_Missense_Mutation_p.S964C	NM_001146116.1|NM_015151.3	NP_001139588.1|NP_055966.2	Q14689	DIP2A_HUMAN	DIP2 disco-interacting protein 2 homolog A (Drosophila)	968					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(22)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		GCTCAGGCTTCCGGGAGAGAG	0.627000													8	23					0	0	0.000673444	0	0
WDR72	256764	broad.mit.edu	37	15	53908382	53908382	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr15:53908382C>T	ENST00000396328.1	-	15	2260	c.2021G>A	c.(2020-2022)tGg>tAg	p.W674*	WDR72_ENST00000557913.1_Nonsense_Mutation_p.W671*|WDR72_ENST00000559418.1_Nonsense_Mutation_p.W684*|WDR72_ENST00000360509.5_Nonsense_Mutation_p.W674*	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	674										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		AACGTTACTCCATTTTGTCTT	0.368000													14	26					0	0	0.000422831	0	0
ALDH7A1	501	broad.mit.edu	37	5	125891679	125891679	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr5:125891679A>G	ENST00000409134.3	-	12	1256	c.1037T>C	c.(1036-1038)gTt>gCt	p.V346A	ALDH7A1_ENST00000447989.2_Intron|ALDH7A1_ENST00000553117.1_Intron	NM_001182.4|NM_001201377.1	NP_001173.2|NP_001188306.1	P49419	AL7A1_HUMAN	aldehyde dehydrogenase 7 family, member A1	346					cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound	cytosol|mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity|betaine-aldehyde dehydrogenase activity|L-aminoadipate-semialdehyde dehydrogenase activity			endometrium(1)|kidney(4)|large_intestine(4)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	16		all_cancers(142;0.24)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0417)|OV - Ovarian serous cystadenocarcinoma(64;0.068)|all cancers(49;0.109)	NADH(DB00157)|Pyridoxine(DB00165)	TCTGTTTACAACCTCATCATG	0.378000													5	38					0	0	3.59834e-05	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142482242	142482242	+	RNA	SNP	G	G	A	rs143538588	by1000genomes	TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:142482242G>A	ENST00000603901.1	+	0	622					NR_001296.3																						GGTCTGCAATGGACAGCTTCA	0.493000													5	69					0	0	3.59834e-05	0	0
GFRAL	389400	broad.mit.edu	37	6	55223697	55223697	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr6:55223697G>T	ENST00000340465.2	+	6	799	c.713G>T	c.(712-714)aGa>aTa	p.R238I		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	238						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			AGGCACTATAGAACATTTCAG	0.388000													9	78					1.76689e-08	2.20938e-07	0.000442599	1	0
SVEP1	79987	broad.mit.edu	37	9	113221255	113221255	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr9:113221255G>A	ENST00000401783.2	-	19	3797	c.3461C>T	c.(3460-3462)tCc>tTc	p.S1154F	SVEP1_ENST00000302728.8_Missense_Mutation_p.S1154F|SVEP1_ENST00000467821.1_5'UTR|SVEP1_ENST00000374469.1_Missense_Mutation_p.S1131F	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	1154					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						GATGGATCTGGAACCAGCGAA	0.448000													14	56					0	0	0.000566183	0	0
EIF4A3	9775	broad.mit.edu	37	17	78113496	78113496	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr17:78113496C>T	ENST00000269349.3	-	6	780	c.559G>A	c.(559-561)Gat>Aat	p.D187N		NM_014740.3	NP_055555.1	P38919	IF4A3_HUMAN	eukaryotic translation initiation factor 4A3	187	Helicase ATP-binding.				mRNA transport|negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|rRNA processing	catalytic step 2 spliceosome|cytoplasm|exon-exon junction complex|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|poly(A) RNA binding|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	10	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)			TCAGCTTCATCCAAAACCAAC	0.323000													30	59					0	0	0.000279167	0	0
SERPINB7	8710	broad.mit.edu	37	18	61460426	61460426	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr18:61460426T>G	ENST00000398019.2	+	4	576	c.251T>G	c.(250-252)tTt>tGt	p.F84C	SERPINB7_ENST00000336429.2_Missense_Mutation_p.F84C|SERPINB7_ENST00000546027.1_Missense_Mutation_p.F84C|SERPINB7_ENST00000540675.1_Missense_Mutation_p.F67C	NM_003784.3	NP_003775.1	O75635	SPB7_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 7	84					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	27		Esophageal squamous(42;0.129)				AAAAGAGTTTTTTCTGATATA	0.343000													17	49					0	0	0.000566183	0	0
ZNF611	81856	broad.mit.edu	37	19	53209661	53209661	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr19:53209661G>A	ENST00000543227.1	-	6	921	c.647C>T	c.(646-648)tCa>tTa	p.S216L	ZNF611_ENST00000602162.1_Missense_Mutation_p.S147L|ZNF611_ENST00000319783.1_Missense_Mutation_p.S216L|ZNF611_ENST00000540744.1_Missense_Mutation_p.S216L|ZNF611_ENST00000453741.2_Missense_Mutation_p.S147L|ZNF611_ENST00000595798.1_Missense_Mutation_p.S147L	NM_001161499.1	NP_001154971.1	Q8N823	ZN611_HUMAN	zinc finger protein 611	216					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		TGGGAGTAATGAAGAATTCAG	0.378000													40	152					0	0	0.000680045	0	0
RP1	6101	broad.mit.edu	37	8	55533756	55533756	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr8:55533756C>T	ENST00000220676.1	+	2	378	c.230C>T	c.(229-231)cCt>cTt	p.P77L		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	77	Doublecortin 1.				axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GTGCCCCTCCCTTTTGGAGTG	0.612000													29	66					0	0	0.000814825	0	0
LPIN3	64900	broad.mit.edu	37	20	39978454	39978454	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr20:39978454G>T	ENST00000373257.3	+	6	770	c.679G>T	c.(679-681)Gag>Tag	p.E227*		NM_022896.1	NP_075047.1	Q9BQK8	LPIN3_HUMAN	lipin 3	227					fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(7)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Myeloproliferative disorder(115;0.000739)				GAGCGACTCGGAGCTGGAGGT	0.632000													10	27					5.50884e-06	6.75222e-05	0.00010058	1	0
CD5L	922	broad.mit.edu	37	1	157803299	157803299	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:157803299G>A	ENST00000368174.4	-	5	818	c.722C>T	c.(721-723)cCc>cTc	p.P241L		NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	241					apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CAAGTCAAAGGGATCTGCAGG	0.458000													14	72					0	0	0.000219431	0	0
CDH17	1015	broad.mit.edu	37	8	95183182	95183182	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr8:95183182G>A	ENST00000027335.3	-	8	939	c.815C>T	c.(814-816)tCc>tTc	p.S272F	CDH17_ENST00000450165.2_Missense_Mutation_p.S272F|CDH17_ENST00000441892.2_Intron	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	272	Cadherin 3.					integral to membrane	calcium ion binding			NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			GTCAACTAAGGAATATTGTGC	0.448000													36	46					0	0	0.000692331	0	0
LOXL2	4017	broad.mit.edu	37	8	23225594	23225594	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr8:23225594G>A	ENST00000389131.3	-	2	640	c.271C>T	c.(271-273)Cac>Tac	p.H91Y		NM_002318.2	NP_002309.1	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2	91	SRCR 1.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(5)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		TGGGCAGCGTGGATGGAGAAG	0.642000													16	49					0	0	0.000422831	0	0
MYH1	4619	broad.mit.edu	37	17	10418201	10418201	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr17:10418201G>A	ENST00000226207.5	-	6	611	c.517C>T	c.(517-519)Cag>Tag	p.Q173*	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	173	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						AAGATAGACTGATTCTCCCGA	0.323000													55	170					0	0	0.000781405	0	0
BTNL3	10917	broad.mit.edu	37	5	180424410	180424410	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr5:180424410G>A	ENST00000342868.6	+	3	779	c.595G>A	c.(595-597)Gaa>Aaa	p.E199K		NM_197975.2	NP_932079.1	Q6UXE8	BTNL3_HUMAN	butyrophilin-like 3	199	Ig-like V-type.				lipid metabolic process	integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(1)|lung(10)|prostate(2)|skin(1)	25	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.00336)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)|all_lung(500;0.248)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000272)			TATAGTCCAGGAAAATGCTGG	0.488000													14	19					0	0	0.000151284	0	0
AGBL1	123624	broad.mit.edu	37	15	86790961	86790961	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr15:86790961C>T	ENST00000441037.2	+	6	543	c.448C>T	c.(448-450)Cag>Tag	p.Q150*	AGBL1_ENST00000421325.2_Nonsense_Mutation_p.Q150*	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	150					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						CGGGCTGCACCAGGACTGGCA	0.632000													9	13					0	0	0.000442599	0	0
RBM11	54033	broad.mit.edu	37	21	15599221	15599221	+	Silent	SNP	A	A	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr21:15599221A>T	ENST00000400577.3	+	5	462	c.453A>T	c.(451-453)ccA>ccT	p.P151P	RBM11_ENST00000468643.1_3'UTR	NM_144770.3	NP_658983.3	P57052	RBM11_HUMAN	RNA binding motif protein 11	151							nucleotide binding|RNA binding			endometrium(3)|kidney(3)|lung(7)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	16				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		TGTATAATCCAGTGCTGCAGC	0.393000													35	97					0	0	0.000228196	0	0
NHSL2	340527	broad.mit.edu	37	X	71359490	71359490	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chrX:71359490G>A	ENST00000373677.1	+	2	2256	c.994G>A	c.(994-996)Gag>Aag	p.E332K	NHSL2_ENST00000540800.1_Missense_Mutation_p.E698K|NHSL2_ENST00000510661.1_Missense_Mutation_p.E467K|NHSL2_ENST00000535692.1_Missense_Mutation_p.E332K			F5H593	F5H593_HUMAN	NHS-like 2	698										NS(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(10)|lung(7)|stomach(1)	28	Renal(35;0.156)					GGAGGCCAGGGAGATATCATC	0.577000													15	7					0	0	0.000566183	0	0
SLC39A12	221074	broad.mit.edu	37	10	18276511	18276511	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr10:18276511C>T	ENST00000377369.2	+	7	1473	c.1200C>T	c.(1198-1200)atC>atT	p.I400I	SLC39A12_ENST00000539911.1_Silent_p.I266I|SLC39A12_ENST00000377371.3_Silent_p.I400I|SLC39A12_ENST00000377374.4_Silent_p.I400I	NM_001145195.1	NP_001138667.1	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter), member 12	400					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(5)|lung(38)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	60						ACAGGCTTATCTTACAGCTGT	0.542000													22	63					0	0	0.000375601	0	0
SYT7	9066	broad.mit.edu	37	11	61291401	61291401	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr11:61291401C>T	ENST00000263846.4	-	7	1132	c.805G>A	c.(805-807)Gag>Aag	p.E269K	SYT7_ENST00000535826.1_Missense_Mutation_p.E388K|SYT7_ENST00000539008.1_Missense_Mutation_p.E552K|SYT7_ENST00000540677.1_Missense_Mutation_p.E344K|SYT7_ENST00000540831.1_5'UTR|SYT7_ENST00000542670.1_Missense_Mutation_p.E477K|SYT7_ENST00000542836.1_Missense_Mutation_p.E313K	NM_004200.3	NP_004191.2	O43581	SYT7_HUMAN	synaptotagmin VII	269	C2 2.					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			kidney(2)|large_intestine(3)|lung(4)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						AAGAGCAGCTCCCCTCGGCTC	0.602000													26	59					0	0	0.000720815	0	0
CSMD3	114788	broad.mit.edu	37	8	113504731	113504731	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr8:113504731C>T	ENST00000297405.5	-	31	5509	c.5265G>A	c.(5263-5265)ttG>ttA	p.L1755L	CSMD3_ENST00000343508.3_Silent_p.L1715L|CSMD3_ENST00000352409.3_Silent_p.L1755L|CSMD3_ENST00000455883.2_Silent_p.L1651L	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1755	Sushi 9.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GACAACTTGGCAAGGCTCTAT	0.358000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			16	79					0	0	0.000566183	0	0
DDX24	57062	broad.mit.edu	37	14	94545401	94545401	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr14:94545401T>C	ENST00000330836.5	-	2	819	c.688A>G	c.(688-690)Aaa>Gaa	p.K230E	DDX24_ENST00000544005.1_Intron|DDX24_ENST00000555054.1_Missense_Mutation_p.K187E	NM_020414.3	NP_065147.1	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 24	230	Helicase ATP-binding.				RNA metabolic process	cytoplasm|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			cervix(3)|endometrium(4)|kidney(4)|large_intestine(5)|lung(3)|ovary(2)|skin(1)|urinary_tract(1)	23		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		ATGTCCAGTTTGTCACGGATG	0.547000													27	59					0	0	0.000147802	0	0
SBK2	646643	broad.mit.edu	37	19	56047472	56047472	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr19:56047472C>T	ENST00000413299.1	-	2	227	c.190G>A	c.(190-192)Gaa>Aaa	p.E64K	SBK2_ENST00000344158.3_Missense_Mutation_p.E64K	NM_001101401.2	NP_001094871.2	P0C263	SBK2_HUMAN	SH3 domain binding kinase family, member 2	64	Protein kinase.						ATP binding|protein serine/threonine kinase activity			endometrium(1)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9						GGACGCACTTCCTCGTAGAGC	0.662000													14	14					0	0	0.000422831	0	0
MAP2K7	5609	broad.mit.edu	37	19	7968862	7968862	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr19:7968862C>T	ENST00000545011.1	+	1	98	c.33C>T	c.(31-33)tcC>tcT	p.S11S	MAP2K7_ENST00000397983.3_Silent_p.S11S|MAP2K7_ENST00000397981.3_Silent_p.S11S|MAP2K7_ENST00000397979.3_Silent_p.S11S			O14733	MP2K7_HUMAN	mitogen-activated protein kinase kinase 7	11					activation of JUN kinase activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus	ATP binding|JUN kinase kinase activity|magnesium ion binding|protein binding|protein kinase binding|protein phosphatase binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|central_nervous_system(3)|endometrium(1)|large_intestine(8)|lung(4)|ovary(1)	19					Etoposide(DB00773)	AGAAGCTGTCCCGCCTGGAAG	0.697000													10	9					0	0	6.40141e-05	0	0
CFTR	1080	broad.mit.edu	37	7	117232675	117232675	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:117232675G>A	ENST00000003084.6	+	14	2586	c.2454G>A	c.(2452-2454)ttG>ttA	p.L818L	CFTR_ENST00000454343.1_Silent_p.L757L	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	818					respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	AAACTGGCTTGGAAATAAGTG	0.403000									Cystic Fibrosis				34	33					0	0	0.000491102	0	0
PARM1	25849	broad.mit.edu	37	4	75938300	75938300	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr4:75938300G>A	ENST00000307428.7	+	2	921	c.709G>A	c.(709-711)Gag>Aag	p.E237K	PARM1_ENST00000513238.1_Intron|RP11-44F21.2_ENST00000513770.1_RNA	NM_015393.3	NP_056208.2	Q6UWI2	PARM1_HUMAN	prostate androgen-regulated mucin-like protein 1	237					positive regulation of telomerase activity	early endosome|endosome membrane|Golgi membrane|integral to membrane|late endosome|plasma membrane				cervix(1)|endometrium(2)|lung(4)|ovary(1)	8						CATAGACATGGAGACCACCAC	0.498000													13	40					0	0	0.000219431	0	0
NCAM2	4685	broad.mit.edu	37	21	22707868	22707868	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr21:22707868G>A	ENST00000400546.1	+	7	1030	c.781G>A	c.(781-783)Ggg>Agg	p.G261R	NCAM2_ENST00000535285.1_Missense_Mutation_p.G286R|NCAM2_ENST00000284894.7_Missense_Mutation_p.G119R	NM_004540.3	NP_004531.2	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2	261	Ig-like C2-type 3.				neuron cell-cell adhesion	integral to membrane|plasma membrane				breast(4)|cervix(2)|endometrium(8)|kidney(6)|large_intestine(22)|liver(4)|lung(49)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	108		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		CATATTGAAAGGGAGCAATAC	0.388000													4	34					0	0	0.000602214	0	0
TLE4	7091	broad.mit.edu	37	9	82267551	82267551	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr9:82267551C>T	ENST00000376520.4	+	7	1262	c.434C>T	c.(433-435)cCc>cTc	p.P145L	TLE4_ENST00000376534.4_5'UTR|TLE4_ENST00000265284.6_Missense_Mutation_p.P120L|TLE4_ENST00000376544.3_Missense_Mutation_p.P145L|TLE4_ENST00000376537.4_Missense_Mutation_p.P145L|TLE4_ENST00000455913.1_3'UTR|TLE4_ENST00000376552.2_Missense_Mutation_p.P145L			O60756	BCE1_HUMAN	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0										breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						CATGGTCTCCCCGTACCTCTG	0.557000													33	71					0	0	0.000953801	0	0
FSHB	2488	broad.mit.edu	37	11	30255338	30255338	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr11:30255338G>A	ENST00000417547.1	+	3	420	c.381G>A	c.(379-381)atG>atA	p.M127I	FSHB_ENST00000533718.1_Missense_Mutation_p.M127I|FSHB_ENST00000254122.3_Missense_Mutation_p.M127I	NM_001018080.1	NP_001018090.1	P01225	FSHB_HUMAN	follicle stimulating hormone, beta polypeptide	127					cellular nitrogen compound metabolic process|female gamete generation|female pregnancy|ovarian follicle development|peptide hormone processing|progesterone biosynthetic process|spermatogenesis|transforming growth factor beta receptor signaling pathway	cytoplasm|extracellular region|soluble fraction	follicle-stimulating hormone activity|protein heterodimerization activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(3)|skin(1)	12					Follitropin beta(DB00066)|Thyrotropin Alfa(DB00024)|Urofollitropin(DB00094)	TTGGTGAAATGAAAGAATAAA	0.512000													11	14					0	0	6.40141e-05	0	0
AHDC1	27245	broad.mit.edu	37	1	27874537	27874537	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:27874537G>C	ENST00000374011.2	-	6	5058	c.4090C>G	c.(4090-4092)Cac>Gac	p.H1364D	AHDC1_ENST00000247087.5_Missense_Mutation_p.H1364D|AHDC1_ENST00000482400.2_Intron	NM_001029882.2	NP_001025053.1	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	1364							DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GAGTCGCAGTGGAAGCCTTGG	0.647000													21	36					0	0	0.000132079	0	0
UNC13D	201294	broad.mit.edu	37	17	73835948	73835948	+	Missense_Mutation	SNP	C	C	T	rs150442758		TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr17:73835948C>T	ENST00000207549.4	-	12	1406	c.1027G>A	c.(1027-1029)Gac>Aac	p.D343N	UNC13D_ENST00000412096.2_Missense_Mutation_p.D343N|UNC13D_ENST00000587504.1_5'UTR	NM_199242.2	NP_954712.1	Q70J99	UN13D_HUMAN	unc-13 homolog D (C. elegans)	343	Interaction with RAB27A.				positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			TCGGATAGGTCCTTCTGTGTG	0.667000									Familial Hemophagocytic Lymphohistiocytosis				12	75					0	0	0.00010058	0	0
SHCBP1L	81626	broad.mit.edu	37	1	182898843	182898843	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:182898843C>T	ENST00000367547.3	-	6	1357	c.1121G>A	c.(1120-1122)gGa>gAa	p.G374E	SHCBP1L_ENST00000423786.1_Missense_Mutation_p.G255E|SHCBP1L_ENST00000488956.1_5'UTR	NM_030933.2	NP_112195.2	Q9BZQ2	SHP1L_HUMAN	SHC SH2-domain binding protein 1-like	446										breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|pancreas(1)|prostate(1)|skin(2)	15						TTCTCTTTTTCCTTTCCTACG	0.274000													41	60					0	0	0.000781405	0	0
OR14A16	284532	broad.mit.edu	37	1	247978756	247978756	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:247978756G>A	ENST00000357627.1	-	1	275	c.276C>T	c.(274-276)ttC>ttT	p.F92F		NM_001001966.1	NP_001001966.1	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A, member 16	92					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F92L(1)		breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(32)|skin(2)|stomach(1)	45						CACAGCCAAGGAATGAAATGG	0.438000													33	31					0	0	0.00058488	0	0
ABLIM1	3983	broad.mit.edu	37	10	116361657	116361657	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr10:116361657C>T	ENST00000533213.2	-	2	429	c.128G>A	c.(127-129)gGg>gAg	p.G43E	ABLIM1_ENST00000369252.4_Missense_Mutation_p.G43E|ABLIM1_ENST00000277895.5_Missense_Mutation_p.G103E|ABLIM1_ENST00000477638.1_5'UTR			O14639	ABLM1_HUMAN	actin binding LIM protein 1	103					axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	30		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		GCAAGGCTCCCCACATTTATG	0.512000													8	44					0	0	0.000274275	0	0
FKBPL	63943	broad.mit.edu	37	6	32096980	32096980	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr6:32096980G>C	ENST00000375156.3	-	2	848	c.578C>G	c.(577-579)aCt>aGt	p.T193S		NM_022110.3	NP_071393.2	Q9UIM3	FKBPL_HUMAN	FK506 binding protein like	193					response to radiation	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity										TCGGCCTTGAGTGAAGGATGC	0.567000													77	470					0	0	0.000781405	0	0
DSCAM	1826	broad.mit.edu	37	21	41725649	41725649	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr21:41725649G>A	ENST00000400454.1	-	5	1154	c.677C>T	c.(676-678)tCc>tTc	p.S226F		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	226	Ig-like C2-type 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				ATCCAGTATGGATGGGGCTGA	0.512000													6	15					0	0	3.59834e-05	0	0
ROS1	6098	broad.mit.edu	37	6	117639394	117639394	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr6:117639394C>T	ENST00000368508.3	-	37	6160	c.5962G>A	c.(5962-5964)Gac>Aac	p.D1988N	ROS1_ENST00000368507.3_Missense_Mutation_p.D1982N|GOPC_ENST00000467125.1_5'UTR	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	1988	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TTCTCCTGGTCTGTGGAACCC	0.408000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								7	27					0	0	0.000274275	0	0
DEFB119	245932	broad.mit.edu	37	20	29977001	29977001	+	Silent	SNP	A	A	G			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr20:29977001A>G	ENST00000376315.2	-	2	93	c.94T>C	c.(94-96)Ttg>Ctg	p.L32L	DEFB119_ENST00000376321.3_Intron|DEFB119_ENST00000492344.1_Intron|DEFB119_ENST00000339144.3_Intron	NM_001271209.1|NM_153323.4	NP_001258138.1|NP_697018.1	Q8N690	DB119_HUMAN	defensin, beta 119	38					defense response to bacterium	extracellular region				large_intestine(2)|lung(1)|prostate(1)	4	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			TCTTTGCACAACAACCGGCAG	0.443000													45	117					0	0	0.000781405	0	0
FILIP1	27145	broad.mit.edu	37	6	76023417	76023417	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr6:76023417G>A	ENST00000393004.2	-	5	2352	c.2131C>T	c.(2131-2133)Cgg>Tgg	p.R711W	FILIP1_ENST00000237172.7_Missense_Mutation_p.R711W|FILIP1_ENST00000370020.1_Missense_Mutation_p.R612W|FILIP1_ENST00000498523.1_5'UTR			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	711								p.R711W(1)		breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						TCTTCCAACCGAAATCTGTGT	0.413000													55	143					0	0	0.000781405	0	0
HIST1H1B	3009	broad.mit.edu	37	6	27834783	27834783	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr6:27834783C>T	ENST00000331442.3	-	1	576	c.525G>A	c.(523-525)aaG>aaA	p.K175K		NM_005322.2	NP_005313.1	P16401	H15_HUMAN	histone cluster 1, H1b	175					nucleosome assembly	nucleosome|nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(12)|prostate(2)|upper_aerodigestive_tract(2)	24						CCTTGGCCTTCTTAGGGCTCT	0.592000													55	57					0	0	0.000781405	0	0
TLR7	51284	broad.mit.edu	37	X	12905795	12905795	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chrX:12905795G>A	ENST00000380659.3	+	3	2307	c.2168G>A	c.(2167-2169)aGa>aAa	p.R723K		NM_016562.3	NP_057646.1	Q9NYK1	TLR7_HUMAN	toll-like receptor 7	723					cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			NS(1)|breast(4)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	44					Imiquimod(DB00724)	AACTGTTCCAGAAGCCTCAAG	0.428000													52	22					0	0	0.000781405	0	0
OR5M9	390162	broad.mit.edu	37	11	56230195	56230195	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr11:56230195G>A	ENST00000279791.1	-	1	682	c.683C>T	c.(682-684)tCt>tTt	p.S228F		NM_001004743.1	NP_001004743.1	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M, member 9	228					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	36	Esophageal squamous(21;0.00448)					GCCATCGGCAGAGCGCATGCG	0.498000													7	17					0	0	8.12818e-05	0	0
CYP11B1	1584	broad.mit.edu	37	8	143959214	143959214	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr8:143959214G>A	ENST00000377675.3	-	4	573	c.567C>T	c.(565-567)ttC>ttT	p.F189F	CYP11B1_ENST00000517471.1_Intron|CYP11B1_ENST00000292427.4_Intron			P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 1	133					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(36)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	67	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	TGCCCCCAGGGAATGGTGGGG	0.522000									Familial Hyperaldosteronism type I				8	36					0	0	0.00010058	0	0
C1orf87	127795	broad.mit.edu	37	1	60505724	60505724	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:60505724G>A	ENST00000371201.3	-	5	719	c.612C>T	c.(610-612)atC>atT	p.I204I	C1orf87_ENST00000450089.2_Intron	NM_152377.2	NP_689590.1	Q8N0U7	CA087_HUMAN	chromosome 1 open reading frame 87	204							calcium ion binding			breast(2)|endometrium(2)|large_intestine(6)|lung(19)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33						TTGGGTCCAGGATCTTCAGCT	0.428000													28	87					0	0	0.000279167	0	0
VWC2	375567	broad.mit.edu	37	7	49842381	49842381	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:49842381G>A	ENST00000340652.3	+	3	1327	c.771G>A	c.(769-771)acG>acA	p.T257T		NM_198570.3	NP_940972.2	Q2TAL6	VWC2_HUMAN	von Willebrand factor C domain containing 2	257	VWFC 2.				negative regulation of BMP signaling pathway|positive regulation of neuron differentiation	basement membrane|extracellular space				cervix(1)|endometrium(2)|large_intestine(1)|lung(3)|prostate(1)	8						GTCCCCAGACGGAGTGTGTGG	0.572000													12	106					0	0	0.00010058	0	0
TCF3	6929	broad.mit.edu	37	19	1622363	1622363	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr19:1622363G>A	ENST00000262965.5	-	9	945	c.601C>T	c.(601-603)Ccg>Tcg	p.P201S	TCF3_ENST00000344749.5_Missense_Mutation_p.P201S|TCF3_ENST00000588136.1_Missense_Mutation_p.P201S|TCF3_ENST00000453954.2_Missense_Mutation_p.P117S|TCF3_ENST00000395423.3_Missense_Mutation_p.P150S	NM_003200.3	NP_003191.1	P15923	TFE2_HUMAN	transcription factor 3	201					B cell lineage commitment|G1 phase of mitotic cell cycle|immunoglobulin V(D)J recombination|muscle cell differentiation|positive regulation of B cell proliferation|positive regulation of cell cycle|positive regulation of muscle cell differentiation|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus|protein complex|transcription factor complex	bHLH transcription factor binding|DNA binding|E-box binding|identical protein binding|mitogen-activated protein kinase kinase kinase binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|vitamin D response element binding			breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	16		Acute lymphoblastic leukemia(61;5.94e-12)|all_hematologic(61;1.27e-07)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTGGCGGACGGGTAGGCGGTG	0.716000			T	"""PBX1, HLF, TFPT"""	pre B-ALL								6	8					0	0	0.000442599	0	0
HIVEP1	3096	broad.mit.edu	37	6	12122047	12122047	+	Silent	SNP	T	T	G			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr6:12122047T>G	ENST00000379388.2	+	4	2351	c.2019T>G	c.(2017-2019)tcT>tcG	p.S673S		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	673					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GTACGGATTCTGGTTACTTTT	0.502000													14	27					0	0	0.000308642	0	0
SHANK3	85358	broad.mit.edu	37	22	51123067	51123067	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr22:51123067G>A	ENST00000414786.2	+	9	1245	c.1018G>A	c.(1018-1020)Gac>Aac	p.D340N	SHANK3_ENST00000262795.3_Missense_Mutation_p.D340N|SHANK3_ENST00000445220.2_Missense_Mutation_p.D340N			F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	340										central_nervous_system(1)|endometrium(1)|kidney(1)|lung(5)	8		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		GACCCACAAAGACTCGGATGT	0.572000													25	44					0	0	0.000279167	0	0
ZNF436	80818	broad.mit.edu	37	1	23688771	23688771	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:23688771C>T	ENST00000314011.4	-	4	1240	c.1104G>A	c.(1102-1104)ggG>ggA	p.G368G	ZNF436_ENST00000374608.3_Silent_p.G368G|ZNF436_ENST00000374609.1_Intron	NM_001077195.1	NP_001070663.1	Q9C0F3	ZN436_HUMAN	zinc finger protein 436	368					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	19		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;5.97e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000977)|KIRC - Kidney renal clear cell carcinoma(1967;0.00336)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		TGAAGCTTTTCCCACAAGCAT	0.463000													47	61					0	0	0.000680045	0	0
TMPRSS4	56649	broad.mit.edu	37	11	117965536	117965536	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr11:117965536G>A	ENST00000534111.1	+	2	268		c.e2-1		TMPRSS4_ENST00000523251.1_Splice_Site|TMPRSS4_ENST00000522824.1_Silent_p.Q3Q|TMPRSS4_ENST00000522307.1_Splice_Site|TMPRSS4_ENST00000437212.3_Silent_p.Q3Q	NM_001083947.1|NM_001173551.1|NM_019894.3	NP_001077416.1|NP_001167022.1|NP_063947.1	Q9NRS4	TMPS4_HUMAN	transmembrane protease, serine 4						proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	19	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0431)|all_hematologic(192;0.164)|Breast(348;0.183)|all_neural(223;0.238)		BRCA - Breast invasive adenocarcinoma(274;4.16e-05)|Epithelial(105;0.00204)		TTCAATTACAGGATCCTGACA	0.512000													4	11					0	0	8.12818e-05	0	0
EYA4	2070	broad.mit.edu	37	6	133836476	133836476	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr6:133836476A>G	ENST00000367895.5	+	17	1983	c.1519A>G	c.(1519-1521)Aag>Gag	p.K507E	EYA4_ENST00000525849.1_Missense_Mutation_p.K484E|EYA4_ENST00000430974.2_Missense_Mutation_p.K459E|EYA4_ENST00000355167.3_Missense_Mutation_p.K507E|EYA4_ENST00000452339.2_Missense_Mutation_p.K453E|EYA4_ENST00000431403.2_Missense_Mutation_p.K507E|RP3-323P13.2_ENST00000607033.1_RNA|EYA4_ENST00000355286.6_Missense_Mutation_p.K484E|EYA4_ENST00000531901.1_Missense_Mutation_p.K513E	NM_004100.4	NP_004091.3	O95677	EYA4_HUMAN	eyes absent homolog 4 (Drosophila)	507					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|skin(1)	48	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		TGGCCCTGCCAAGAGGGATGC	0.433000													35	81					0	0	0.000814825	0	0
ACO1	48	broad.mit.edu	37	9	32407274	32407274	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr9:32407274C>T	ENST00000379923.1	+	4	319	c.113C>T	c.(112-114)tCg>tTg	p.S38L	ACO1_ENST00000541043.1_5'UTR|ACO1_ENST00000309951.5_Missense_Mutation_p.S38L	NM_001278352.1	NP_001265281.1	P21399	ACOC_HUMAN	aconitase 1, soluble	38					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding			breast(1)|endometrium(7)|kidney(5)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	30			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		TTACCATTTTCGATCAGAGTT	0.383000													13	59					0	0	0.000308642	0	0
CCDC141	285025	broad.mit.edu	37	2	179702368	179702368	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr2:179702368T>C	ENST00000420890.2	-	23	3695	c.3578A>G	c.(3577-3579)gAc>gGc	p.D1193G	CCDC141_ENST00000480419.1_5'UTR|CCDC141_ENST00000295723.5_Missense_Mutation_p.D618G	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	618							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CAGGAGCAGGTCCTGGACGCC	0.562000													39	75					0	0	0.000781405	0	0
CXCR2	3579	broad.mit.edu	37	2	219000495	219000495	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr2:219000495G>A	ENST00000318507.2	+	3	1398	c.971G>A	c.(970-972)gGa>gAa	p.G324E		NM_001557.3	NP_001548.1	P25025	CXCR2_HUMAN	chemokine (C-X-C motif) receptor 2	324					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(11)|skin(1)|stomach(1)	22						TTTCGCCATGGACTCCTCAAG	0.547000													38	86					0	0	0.000680045	0	0
ZNF479	90827	broad.mit.edu	37	7	57200000	57200000	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:57200000C>T	ENST00000331162.4	-	2	302	c.32G>A	c.(31-33)cGa>cAa	p.R11Q		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	11					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			CACCATTTCTCGGCTTCCAGG	0.552000													36	33					0	0	0.000228196	0	0
SEMA5B	54437	broad.mit.edu	37	3	122634311	122634311	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr3:122634311G>A	ENST00000195173.4	-	14	2267	c.1964C>T	c.(1963-1965)gCc>gTc	p.A655V	SEMA5B_ENST00000357599.3_Missense_Mutation_p.A655V|SEMA5B_ENST00000451055.2_Missense_Mutation_p.A709V			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	655					cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		GATGTGGATGGCTGGCCCCAG	0.612000													14	28					0	0	0.000566183	0	0
KDM5A	5927	broad.mit.edu	37	12	438098	438098	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr12:438098G>A	ENST00000399788.2	-	14	2233	c.1871C>T	c.(1870-1872)cCa>cTa	p.P624L	KDM5A_ENST00000382815.4_Missense_Mutation_p.P624L	NM_001042603.1	NP_001036068.1	P29375	KDM5A_HUMAN	lysine (K)-specific demethylase 5A	624					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(29)|ovary(1)|prostate(5)|skin(6)|stomach(1)|urinary_tract(2)	77						TAAGCATTCTGGATCTGCTGC	0.463000			T	NUP98	AML								104	45					0	0	0.000781405	0	0
SYT1	6857	broad.mit.edu	37	12	79679739	79679739	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr12:79679739G>A	ENST00000261205.4	+	5	996	c.339G>A	c.(337-339)acG>acA	p.T113T	SYT1_ENST00000393240.3_Silent_p.T113T|SYT1_ENST00000457153.2_Silent_p.T113T|SYT1_ENST00000552744.1_Silent_p.T113T	NM_005639.2	NP_005630.1	P21579	SYT1_HUMAN	synaptotagmin I	113					detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|pancreas(2)|skin(6)	25						TAGGGAAGACGATGAAAGATC	0.274000													11	19					0	0	0.000308642	0	0
MED12L	116931	broad.mit.edu	37	3	150877703	150877703	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr3:150877703G>A	ENST00000474524.1	+	7	960	c.922G>A	c.(922-924)Gat>Aat	p.D308N	MED12L_ENST00000273432.4_Intron|MED12L_ENST00000309237.4_Missense_Mutation_p.D308N|MED12L_ENST00000422248.2_Missense_Mutation_p.D308N	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	308					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCTGCTGAGCGATAGCCCCAA	0.577000													30	81					0	0	0.000279167	0	0
EDF1	8721	broad.mit.edu	37	9	139757824	139757824	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr9:139757824G>A	ENST00000371648.4	-	3	214	c.207C>T	c.(205-207)caC>caT	p.H69H	EDF1_ENST00000371649.1_Silent_p.H69H|EDF1_ENST00000224073.1_Silent_p.H69H	NM_153200.1	NP_694880.1	O60869	EDF1_HUMAN	endothelial differentiation-related factor 1	69	Interaction with NR5A2, PPARG and NR1H3.|Interaction with TBP and NR5A1.				endothelial cell differentiation|multicellular organismal development|positive regulation of DNA binding|positive regulation of transcription, DNA-dependent|regulation of lipid metabolic process|transcription, DNA-dependent	cytoplasm|nucleolus|nucleus	calmodulin binding|protein binding|sequence-specific DNA binding|transcription coactivator activity			lung(1)	1	all_cancers(76;0.0841)|all_epithelial(76;0.217)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		CCCTGTCATGGTGCAGCTCCT	0.612000													5	23					0	0	3.59834e-05	0	0
POM121L12	285877	broad.mit.edu	37	7	53103782	53103782	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:53103782G>A	ENST00000408890.4	+	1	434	c.418G>A	c.(418-420)Ggg>Agg	p.G140R		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	140										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						GGTGACCATCGGGATCGCGCC	0.716000													8	37					0	0	0.000274275	0	0
NOSIP	51070	broad.mit.edu	37	19	50060403	50060403	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr19:50060403A>C	ENST00000391853.3	-	6	513	c.362T>G	c.(361-363)aTc>aGc	p.I121S	NOSIP_ENST00000596358.1_Missense_Mutation_p.I121S|NOSIP_ENST00000339093.3_Missense_Mutation_p.I121S	NM_015953.3	NP_057037.1	Q9Y314	NOSIP_HUMAN	nitric oxide synthase interacting protein	121					negative regulation of nitric-oxide synthase activity|nitric oxide metabolic process	cytosol|nucleus	protein binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)|skin(2)|urinary_tract(1)	11		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00321)|GBM - Glioblastoma multiforme(134;0.0133)		CCGGCTCACGATAGCCGACTC	0.687000													6	24					0	0	0.000442599	0	0
IDE	3416	broad.mit.edu	37	10	94267908	94267908	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr10:94267908A>T	ENST00000265986.6	-	8	1171	c.1115T>A	c.(1114-1116)tTt>tAt	p.F372Y		NM_004969.3	NP_004960.2	P14735	IDE_HUMAN	insulin-degrading enzyme	372					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|urinary_tract(2)	33					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AATGATAAAAAACATAAAACC	0.353000													52	201					0	0	0.000781405	0	0
VHLL	391104	broad.mit.edu	37	1	156268786	156268786	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:156268786G>A	ENST00000339922.3	-	1	642	c.195C>T	c.(193-195)atC>atT	p.I65I		NM_001004319.2	NP_001004319.1	Q6RSH7	VHLL_HUMAN	von Hippel-Lindau tumor suppressor-like	65	Beta-domain.				protein ubiquitination	nucleus				endometrium(1)|lung(2)|ovary(1)	4	Hepatocellular(266;0.158)					CAGGCAGCACGATTCGTGGGC	0.607000													11	29					0	0	0.000673444	0	0
GNB2L1	10399	broad.mit.edu	37	5	180666103	180666103	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr5:180666103G>A	ENST00000512805.1	-	5	1008	c.600C>T	c.(598-600)gtC>gtT	p.V200V	GNB2L1_ENST00000376817.4_Silent_p.V156V|GNB2L1_ENST00000511900.1_Silent_p.V152V|GNB2L1_ENST00000511566.1_Silent_p.V200V|GNB2L1_ENST00000504726.1_Intron	NM_006098.4	NP_006089.1	P63244	GBLP_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	200					apoptosis|cell cycle|gastrulation|interspecies interaction between organisms|negative regulation of cell growth|negative regulation of phagocytosis|negative regulation of translation|negative regulation of Wnt receptor signaling pathway|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of gastrulation|positive regulation of GTPase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein homooligomerization|positive regulation of protein phosphorylation|regulation of cell cycle|regulation of cell division|regulation of establishment of cell polarity|regulation of protein localization|rhythmic process	cytoskeleton|dendrite|midbody|nucleus|perikaryon|perinuclear region of cytoplasm|phagocytic cup|small ribosomal subunit	ion channel inhibitor activity|protein kinase C binding|protein phosphatase binding|protein tyrosine kinase inhibitor activity|receptor tyrosine kinase binding|SH2 domain binding			lung(3)|skin(2)	5	all_cancers(89;8.79e-06)|all_epithelial(37;1.13e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0654)	all_cancers(40;0.000209)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.101)|all cancers(165;0.11)		CATCTGGAGAGACAGTCACCG	0.537000													44	76					0	0	0.000781405	0	0
OR4A47	403253	broad.mit.edu	37	11	48511051	48511051	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr11:48511051C>A	ENST00000446524.1	+	1	783	c.707C>A	c.(706-708)tCa>tAa	p.S236*		NM_001005512.2	NP_001005512.2	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A, member 47	236					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S236*(1)		NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(18)|ovary(1)|skin(1)|urinary_tract(2)	29						AAAGCCCTCTCAACCTGCAGT	0.433000													14	101					1.5842e-08	1.98666e-07	0.000151284	1	0
FASTKD2	22868	broad.mit.edu	37	2	207652766	207652766	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr2:207652766G>C	ENST00000236980.6	+	9	2048	c.1700G>C	c.(1699-1701)cGg>cCg	p.R567P	FASTKD2_ENST00000403094.3_Missense_Mutation_p.R567P|FASTKD2_ENST00000402774.3_Missense_Mutation_p.R567P	NM_014929.3	NP_055744.2	Q9NYY8	FAKD2_HUMAN	FAST kinase domains 2	567					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(2)	21				LUSC - Lung squamous cell carcinoma(261;0.0718)|Epithelial(149;0.119)|Lung(261;0.138)		CAGCTGCCGCGGGAGCTGCCA	0.493000													4	53					0	0	0.000602214	0	0
UBE3B	89910	broad.mit.edu	37	12	109971326	109971326	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr12:109971326C>T	ENST00000342494.3	+	27	3573	c.2978C>T	c.(2977-2979)cCa>cTa	p.P993L	UBE3B_ENST00000535089.1_Missense_Mutation_p.P80L|UBE3B_ENST00000434735.2_Missense_Mutation_p.P993L	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	993	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						CTCAAGCCTCCATTCTCCATC	0.632000													5	80					0	0	0.000602214	0	0
SLC22A16	85413	broad.mit.edu	37	6	110777985	110777985	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr6:110777985C>T	ENST00000368919.3	-	2	355	c.289G>A	c.(289-291)Gag>Aag	p.E97K	SLC22A16_ENST00000456137.2_Missense_Mutation_p.E97K|SLC22A16_ENST00000461487.1_5'UTR|SLC22A16_ENST00000439654.1_Missense_Mutation_p.E97K|SLC22A16_ENST00000330550.4_Missense_Mutation_p.E63K	NM_033125.3	NP_149116.2	Q86VW1	S22AG_HUMAN	solute carrier family 22 (organic cation/carnitine transporter), member 16	97					acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		CTTGAGAGCTCCCAGATCTCA	0.473000													17	122					0	0	0.000229342	0	0
NOL4	8715	broad.mit.edu	37	18	31523129	31523129	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr18:31523129G>A	ENST00000261592.5	-	9	1739	c.1442C>T	c.(1441-1443)cCt>cTt	p.P481L	NOL4_ENST00000538587.1_Missense_Mutation_p.P407L|NOL4_ENST00000589544.1_Intron|NOL4_ENST00000535384.1_Missense_Mutation_p.P196L|NOL4_ENST00000535475.1_Missense_Mutation_p.P262L|NOL4_ENST00000269185.4_Intron	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	481						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						AAGGTGGGAAGGAATAGGTCG	0.418000													18	44					0	0	0.00074312	0	0
SH3BP4	23677	broad.mit.edu	37	2	235943748	235943748	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr2:235943748C>T	ENST00000409212.1	+	3	609	c.102C>T	c.(100-102)agC>agT	p.S34S	SH3BP4_ENST00000392011.2_Silent_p.S34S|SH3BP4_ENST00000344528.4_Silent_p.S34S			Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	34					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(6)|stomach(3)|urinary_tract(2)	44		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		CAGAGACGAGCTTTAATGACA	0.527000													19	44					0	0	0.000375601	0	0
ZNF106	64397	broad.mit.edu	37	15	42743614	42743614	+	Missense_Mutation	SNP	A	A	G	rs139622071		TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr15:42743614A>G	ENST00000263805.4	-	2	1113	c.787T>C	c.(787-789)Tgg>Cgg	p.W263R	ZNF106_ENST00000565611.1_Intron|ZNF106_ENST00000565380.1_Intron	NM_022473.1	NP_071918.1			zinc finger protein 106																		TTCTTGTTCCATAGCATAGTC	0.378000													15	45					0	0	0.000308642	0	0
CGN	57530	broad.mit.edu	37	1	151491671	151491671	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:151491671G>A	ENST00000271636.7	+	2	809	c.676G>A	c.(676-678)Gaa>Aaa	p.E226K		NM_020770.2	NP_065821.1	Q9P2M7	CING_HUMAN	cingulin	220	Head.|Interacts with ZO-2.					myosin complex|tight junction	actin binding|motor activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			CACCTTTGAGGAACGGGAGCG	0.627000													12	95					0	0	0.000151284	0	0
PKD2L2	27039	broad.mit.edu	37	5	137228269	137228269	+	Silent	SNP	T	T	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr5:137228269T>C	ENST00000508638.1	+	3	289	c.234T>C	c.(232-234)ttT>ttC	p.F78F	PKD2L2_ENST00000508883.1_Silent_p.F78F|PKD2L2_ENST00000290431.5_Silent_p.F78F|PKD2L2_ENST00000502810.1_Silent_p.F78F|PKD2L2_ENST00000350250.4_Silent_p.F44F	NM_001258449.1	NP_001245378.1	Q9NZM6	PK2L2_HUMAN	polycystic kidney disease 2-like 2	78						integral to membrane	calcium ion binding|ion channel activity			breast(1)|endometrium(7)|kidney(4)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(2)	28			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GAACCAACTTTAAGTCCATTC	0.388000													33	56					0	0	0.000191422	0	0
PSMF1	9491	broad.mit.edu	37	20	1115875	1115875	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr20:1115875C>T	ENST00000335877.6	+	4	653	c.477C>T	c.(475-477)ccC>ccT	p.P159P	PSMF1_ENST00000246015.4_Silent_p.P159P|PSMF1_ENST00000484891.1_3'UTR|PSMF1_ENST00000438768.2_Intron|PSMF1_ENST00000333082.3_Silent_p.P159P|PSMF1_ENST00000381898.4_Silent_p.P71P	NM_006814.3	NP_006805.2	Q92530	PSMF1_HUMAN	proteasome (prosome, macropain) inhibitor subunit 1 (PI31)	159	Pro-rich.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome core complex	endopeptidase inhibitor activity|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(8)	13						GGGAGTTCCCCCCTGCTACCG	0.582000													18	17					0	0	0.000958276	0	0
RP1	6101	broad.mit.edu	37	8	55540336	55540336	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr8:55540336C>T	ENST00000220676.1	+	4	4042	c.3894C>T	c.(3892-3894)ttC>ttT	p.F1298F		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1298					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AGGCTTGTTTCCTAGGAGAGG	0.413000													57	81					0	0	0.000781405	0	0
PI4KB	5298	broad.mit.edu	37	1	151278757	151278757	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:151278757C>T	ENST00000368875.2	-	6	1881	c.1301G>A	c.(1300-1302)cGa>cAa	p.R434Q	PI4KB_ENST00000368874.4_Missense_Mutation_p.R407Q|PI4KB_ENST00000368873.1_Missense_Mutation_p.R422Q|PI4KB_ENST00000368872.1_Missense_Mutation_p.R407Q|PI4KB_ENST00000271657.5_Missense_Mutation_p.R434Q|PI4KB_ENST00000529142.1_Missense_Mutation_p.R90Q	NM_002651.2	NP_002642.1	Q9UBF8	PI4KB_HUMAN	phosphatidylinositol 4-kinase, catalytic, beta	422					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(5)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			ACTCCGAATTCGGTTCTCGGG	0.527000													21	35					0	0	0.000586117	0	0
FAT3	120114	broad.mit.edu	37	11	92531411	92531411	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr11:92531411C>T	ENST00000298047.6	+	9	5249	c.5232C>T	c.(5230-5232)acC>acT	p.T1744T	FAT3_ENST00000409404.2_Silent_p.T1744T|FAT3_ENST00000525166.1_Silent_p.T1594T			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1744	Cadherin 15.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TTCAGGCCACCAATATGGCAG	0.423000										TCGA Ovarian(4;0.039)			104	391					0	0	0.000781405	0	0
DYSF	8291	broad.mit.edu	37	2	71816787	71816787	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr2:71816787A>G	ENST00000258104.3	+	31	3690	c.3413A>G	c.(3412-3414)aAc>aGc	p.N1138S	DYSF_ENST00000429174.2_Missense_Mutation_p.N1138S|DYSF_ENST00000410020.3_Missense_Mutation_p.N1156S|DYSF_ENST00000409762.1_Missense_Mutation_p.N1155S|DYSF_ENST00000409744.1_Missense_Mutation_p.N1125S|DYSF_ENST00000409651.1_Missense_Mutation_p.N1170S|DYSF_ENST00000409366.1_Missense_Mutation_p.N1139S|DYSF_ENST00000413539.2_Missense_Mutation_p.N1169S|DYSF_ENST00000409582.3_Missense_Mutation_p.N1155S|DYSF_ENST00000410041.1_Missense_Mutation_p.N1156S|DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000394120.2_Missense_Mutation_p.N1139S	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1138						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						TTCGGTGTGAACAGACCCACG	0.517000													8	122					0	0	6.40141e-05	0	0
PLCH1	23007	broad.mit.edu	37	3	155200266	155200266	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr3:155200266C>T	ENST00000460012.1	-	23	3816	c.3459G>A	c.(3457-3459)gaG>gaA	p.E1153E	PLCH1_ENST00000447496.2_3'UTR|PLCH1_ENST00000414191.1_Silent_p.E1153E|PLCH1_ENST00000334686.6_Silent_p.E1153E|PLCH1_ENST00000340059.7_Silent_p.E1191E|PLCH1_ENST00000494598.1_Intron			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	1191					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			AACTGCCCGGCTCATTCTCAT	0.433000													17	37					0	0	0.000566183	0	0
MGAM	8972	broad.mit.edu	37	7	141803141	141803141	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:141803141G>A	ENST00000475668.2	+	70	8140	c.8086G>A	c.(8086-8088)Gaa>Aaa	p.E2696K	MGAM_ENST00000549489.2_Missense_Mutation_p.E1800K			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1800					polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GGGCTACATTGAAATCTGGGG	0.428000													5	32					0	0	0.000602214	0	0
AHR	196	broad.mit.edu	37	7	17373557	17373557	+	Silent	SNP	T	T	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:17373557T>C	ENST00000242057.4	+	7	1370	c.727T>C	c.(727-729)Tta>Cta	p.L243L		NM_001621.4	NP_001612.1	P35869	AHR_HUMAN	aryl hydrocarbon receptor	243					apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|urinary_tract(3)	33	Lung NSC(10;0.0392)|all_lung(11;0.0754)					CCAAGGGAAGTTAAAGTATCT	0.348000													49	43					0	0	0.000781405	0	0
SNX12	29934	broad.mit.edu	37	X	70281772	70281772	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chrX:70281772G>A	ENST00000374274.3	-	3	423	c.307C>T	c.(307-309)Cct>Tct	p.P103S	SNX12_ENST00000465030.1_Intron|SNX12_ENST00000276105.3_Missense_Mutation_p.P99S	NM_001256185.1|NM_001256188.1|NM_013346.3	NP_001243114.1|NP_001243117.1|NP_037478.2	Q9UMY4	SNX12_HUMAN	sorting nexin 12	103	PX.				cell communication|protein transport	membrane	phosphatidylinositol binding|protein binding			endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	8	Renal(35;0.156)					CCTCGGAAAGGGAGCTGCCGC	0.522000													22	12					0	0	0.00047179	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37419276	37419276	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr10:37419276C>T	ENST00000374660.1	+	3	411	c.312C>T	c.(310-312)tcC>tcT	p.S104S	ANKRD30A_ENST00000361713.1_Silent_p.S104S|ANKRD30A_ENST00000602533.1_Silent_p.S104S			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	160						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						AACTGCTGTCCCATGGTGCAG	0.378000													6	21					0	0	0.000157383	0	0
TM9SF4	9777	broad.mit.edu	37	20	30745665	30745665	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr20:30745665G>T	ENST00000217315.5	+	14	1687	c.1347G>T	c.(1345-1347)ttG>ttT	p.L449F	TM9SF4_ENST00000398022.2_Missense_Mutation_p.L466F			Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	466						integral to membrane				central_nervous_system(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TCGTCTACTTGGGCTACTACT	0.597000													7	125					3.86212e-05	0.000470723	0.000673444	1	0
CUX2	23316	broad.mit.edu	37	12	111652026	111652026	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr12:111652026C>T	ENST00000261726.6	+	2	240	c.86C>T	c.(85-87)tCt>tTt	p.S29F		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	29						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						TCCGTCGCTTCTGAGCTGTCT	0.353000													6	69					0	0	3.59834e-05	0	0
SRGAP3	9901	broad.mit.edu	37	3	9055492	9055492	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr3:9055492G>A	ENST00000383836.3	-	16	2275	c.1848C>T	c.(1846-1848)atC>atT	p.I616I	SRGAP3_ENST00000360413.3_Silent_p.I592I	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	616	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		GGATTTGTTGGATCTGGTGCA	0.527000			T	RAF1	pilocytic astrocytoma								20	35					0	0	0.00047179	0	0
MUC16	94025	broad.mit.edu	37	19	9085057	9085057	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr19:9085057G>A	ENST00000397910.4	-	1	6961	c.6758C>T	c.(6757-6759)tCc>tTc	p.S2253F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2253	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.S2253F(2)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGGGGAGGGGGAAAAGGAGAC	0.458000													6	37					0	0	8.12818e-05	0	0
HADHB	3032	broad.mit.edu	37	2	26501519	26501519	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr2:26501519C>T	ENST00000317799.5	+	8	584	c.480C>T	c.(478-480)atC>atT	p.I160I	HADHB_ENST00000494615.1_3'UTR|HADHB_ENST00000537713.1_Silent_p.I145I|HADHB_ENST00000545822.1_Silent_p.I138I|HADHB_ENST00000405867.3_Intron	NM_000183.2	NP_000174.1	P55084	ECHB_HUMAN	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	160					fatty acid beta-oxidation	mitochondrial nucleoid	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acyltransferase activity|enoyl-CoA hydratase activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTGATGTGATCGTGGCAGGTG	0.423000													34	102					0	0	0.000437636	0	0
DSC3	1825	broad.mit.edu	37	18	28576937	28576937	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr18:28576937C>T	ENST00000434452.1	-	15	2467	c.2313G>A	c.(2311-2313)atG>atA	p.M771I	DSC3_ENST00000360428.4_Missense_Mutation_p.M771I	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	771					homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			CTCCATTTTTCATTCCTGATC	0.443000													6	24					0	0	3.59834e-05	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	155062	155062	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr5:155062G>C	ENST00000283426.6	+	6	1047	c.997G>C	c.(997-999)Ggc>Cgc	p.G333R		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	333					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		AGACCTCGACGGCTCCTTTCC	0.562000													33	27					0	0	0.000409698	0	0
OR9Q1	219956	broad.mit.edu	37	11	57947487	57947487	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr11:57947487G>A	ENST00000335397.3	+	3	887	c.571G>A	c.(571-573)Gag>Aag	p.E191K		NM_001005212.3	NP_001005212.1	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q, member 1	191					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Breast(21;0.222)				GACCTGTGGGGAGAGCTACAC	0.473000													25	35					0	0	0.00047179	0	0
FANCD2	2177	broad.mit.edu	37	3	10140621	10140621	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr3:10140621C>T	ENST00000287647.3	+	43	4496	c.4403C>T	c.(4402-4404)cCa>cTa	p.P1468L	FANCD2OS_ENST00000524279.1_Intron|FANCD2_ENST00000383806.1_Intron|FANCD2_ENST00000383807.1_Intron|FANCD2_ENST00000419585.1_Intron	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	1468					DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TGCCCATTTCCATTCCCTCCA	0.403000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				22	60					0	0	0.00047179	0	0
C7	730	broad.mit.edu	37	5	40937743	40937743	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr5:40937743G>A	ENST00000313164.9	+	6	877	c.518G>A	c.(517-519)gGa>gAa	p.G173E		NM_000587.2	NP_000578.2	P10643	CO7_HUMAN	complement component 7	173	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex							Ovarian(839;0.0112)				AGTGGGGATGGAAAAGATTTC	0.393000													5	13					0	0	0.000602214	0	0
GIF	2694	broad.mit.edu	37	11	59611398	59611398	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr11:59611398C>T	ENST00000541311.1	-	2	369	c.135G>A	c.(133-135)aaG>aaA	p.K45K	GIF_ENST00000257248.2_Silent_p.K70K			P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	70					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			large_intestine(4)|liver(1)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	17						GCTTCTGGGCCTTCAAGTTGT	0.522000													18	29					0	0	0.00074312	0	0
SNX31	169166	broad.mit.edu	37	8	101620768	101620768	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr8:101620768G>A	ENST00000311812.2	-	8	785	c.635C>T	c.(634-636)tCc>tTc	p.S212F	SNX31_ENST00000428383.2_Missense_Mutation_p.S113F	NM_152628.3	NP_689841.3	Q8N9S9	SNX31_HUMAN	sorting nexin 31	212					cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			CATCAGCACGGAGTCGAGGGA	0.527000													25	25					0	0	0.000878237	0	0
INTS1	26173	broad.mit.edu	37	7	1538686	1538686	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:1538686G>A	ENST00000389470.4	-	9	1445	c.1446C>T	c.(1444-1446)ctC>ctT	p.L482L	INTS1_ENST00000404767.3_Silent_p.L354L			Q8N201	INT1_HUMAN	integrator complex subunit 1	354					snRNA processing	integral to membrane|integrator complex|nuclear membrane				autonomic_ganglia(1)|cervix(1)|endometrium(14)|kidney(3)|large_intestine(7)|lung(24)|ovary(1)|prostate(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	62		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		AGGTGGAGGTGAGGAGCCGCA	0.677000													4	7					0	0	0.000602214	0	0
PDE6B	5158	broad.mit.edu	37	4	619541	619541	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr4:619541G>A	ENST00000255622.6	+	1	169	c.126G>A	c.(124-126)ccG>ccA	p.P42P	PDE6B_ENST00000496514.1_Silent_p.P42P	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	42					cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						GGTGCCCGCCGGACTGCGACA	0.642000													31	43					0	0	0.000814825	0	0
OGFR	11054	broad.mit.edu	37	20	61444779	61444779	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr20:61444779C>T	ENST00000370461.1	+	5	3933	c.1656C>T	c.(1654-1656)ccC>ccT	p.P552P	OGFR_ENST00000370468.3_Intron|OGFR_ENST00000290291.6_Silent_p.P604P			Q9NZT2	OGFR_HUMAN	opioid growth factor receptor	604	7 X 20 AA approximate tandem repeats of [ST]-P-S-E-T-P-G-P-[SR]-P-A-G-P-[AT]- [GR]-D-E-P-A-[EK].				regulation of cell growth	cytoplasm|membrane|nucleus	opioid receptor activity			endometrium(2)|kidney(1)|lung(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	17	Breast(26;3.65e-08)					CCCCAGGCCCCCGCCCGGCAG	0.746000													5	6					0	0	3.59834e-05	0	0
CCBE1	147372	broad.mit.edu	37	18	57103350	57103350	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr18:57103350G>A	ENST00000439986.4	-	11	1048	c.1011C>T	c.(1009-1011)ttC>ttT	p.F337F	CCBE1_ENST00000398179.2_Silent_p.F66F	NM_133459.3	NP_597716.1	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	337					lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(3)	24		Colorectal(73;0.175)				TAAGTAGCAGGAAGTCGAAAG	0.537000													26	42					0	0	0.000227799	0	0
FAM179B	23116	broad.mit.edu	37	14	45513962	45513962	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr14:45513962C>T	ENST00000361462.2	+	13	4226	c.4043C>T	c.(4042-4044)gCt>gTt	p.A1348V	FAM179B_ENST00000361577.3_Missense_Mutation_p.A1348V|FAM179B_ENST00000382233.2_3'UTR			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	1348							binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						TTGCACAAGGCTGGTGAATCA	0.368000													18	46					0	0	0.00074312	0	0
ASH1L	55870	broad.mit.edu	37	1	155448249	155448249	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:155448249G>A	ENST00000368346.3	-	3	5051	c.4412C>T	c.(4411-4413)cCt>cTt	p.P1471L	ASH1L_ENST00000392403.3_Missense_Mutation_p.P1471L			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	1471					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			GGCCATCTCAGGAGGAACACT	0.483000													16	78					0	0	0.000958276	0	0
AMER1	139285	broad.mit.edu	37	X	63411447	63411447	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chrX:63411447G>A	ENST00000330258.3	-	2	1992	c.1720C>T	c.(1720-1722)Cgg>Tgg	p.R574W	AMER1_ENST00000374869.3_Missense_Mutation_p.R574W|AMER1_ENST00000403336.1_Missense_Mutation_p.R574W	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									TGCTCCCGCCGAAGCTCCCAA	0.592000													30	26					0	0	0.00058488	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14848843	14848843	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr18:14848843C>T	ENST00000358984.4	+	34	3133	c.2953C>T	c.(2953-2955)Caa>Taa	p.Q985*		NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1070										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						TTGTGTACTACAAAAGGAACT	0.358000													6	19					0	0	0.000274275	0	0
ST3GAL6	10402	broad.mit.edu	37	3	98487368	98487368	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr3:98487368C>T	ENST00000394162.1	+	3	551	c.84C>T	c.(82-84)gtC>gtT	p.V28V	ST3GAL6_ENST00000462152.1_Intron|ST3GAL6_ENST00000483910.1_Silent_p.V28V|ST3GAL6_ENST00000265261.6_5'UTR|ST3GAL6_ENST00000468553.1_Silent_p.V28V	NM_006100.2	NP_006091.1	Q9Y274	SIA10_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 6	28					amino sugar metabolic process|glycolipid metabolic process|protein glycosylation|protein lipoylation	integral to Golgi membrane	sialyltransferase activity			breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(7)|ovary(1)	19						GAACGAATGTCTATTGGTAAG	0.368000													28	89					0	0	0.000184323	0	0
TACC2	10579	broad.mit.edu	37	10	123843922	123843922	+	Missense_Mutation	SNP	C	C	T	rs113893072		TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr10:123843922C>T	ENST00000369005.1	+	4	2247	c.1907C>T	c.(1906-1908)cCc>cTc	p.P636L	TACC2_ENST00000358010.1_Intron|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000453444.2_Missense_Mutation_p.P636L|TACC2_ENST00000334433.3_Missense_Mutation_p.P636L|TACC2_ENST00000515273.1_Missense_Mutation_p.P636L|TACC2_ENST00000515603.1_Missense_Mutation_p.P636L	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	636						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GCACAGCCACCCAGAAAGGGG	0.592000													8	23					0	0	0.000157383	0	0
BRINP3	339479	broad.mit.edu	37	1	190195314	190195314	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:190195314G>A	ENST00000367462.3	-	6	1090	c.859C>T	c.(859-861)Cca>Tca	p.P287S	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Missense_Mutation_p.P185S	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		287						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					TTGCATTCTGGAAATTTGGGA	0.438000													34	35					0	0	0.000814825	0	0
NOSIP	51070	broad.mit.edu	37	19	50060402	50060402	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr19:50060402G>A	ENST00000391853.3	-	6	514	c.363C>T	c.(361-363)atC>atT	p.I121I	NOSIP_ENST00000596358.1_Silent_p.I121I|NOSIP_ENST00000339093.3_Silent_p.I121I	NM_015953.3	NP_057037.1	Q9Y314	NOSIP_HUMAN	nitric oxide synthase interacting protein	121					negative regulation of nitric-oxide synthase activity|nitric oxide metabolic process	cytosol|nucleus	protein binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)|skin(2)|urinary_tract(1)	11		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00321)|GBM - Glioblastoma multiforme(134;0.0133)		GCCGGCTCACGATAGCCGACT	0.692000													6	24					0	0	0.000442599	0	0
RNF40	9810	broad.mit.edu	37	16	30783228	30783228	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr16:30783228C>T	ENST00000324685.6	+	18	3096	c.2661C>T	c.(2659-2661)atC>atT	p.I887I	RNF40_ENST00000567365.1_3'UTR|RNF40_ENST00000563683.1_Silent_p.I847I|RNF40_ENST00000402121.3_Silent_p.I579I|RNF40_ENST00000357890.5_Silent_p.I787I	NM_001207033.1|NM_014771.3	NP_001193962.1|NP_055586.1	O75150	BRE1B_HUMAN	ring finger protein 40, E3 ubiquitin protein ligase	887					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)	30			Colorectal(24;0.198)			TGCGGGAGATCCAGCCCTGCC	0.652000													16	28					0	0	0.000308642	0	0
MTM1	4534	broad.mit.edu	37	X	149767074	149767074	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chrX:149767074T>C	ENST00000370396.2	+	4	209	c.155T>C	c.(154-156)aTa>aCa	p.I52T	MTM1_ENST00000543350.1_Intron|MTM1_ENST00000542741.1_Intron|MTM1_ENST00000413012.2_Missense_Mutation_p.I52T|MTM1_ENST00000306167.7_3'UTR	NM_000252.2	NP_000243.1	Q13496	MTM1_HUMAN	myotubularin 1	52	GRAM.				endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Acute lymphoblastic leukemia(192;6.56e-05)					GTTATTTACATATGTCCTTTC	0.284000													31	18					0	0	0.000814825	0	0
HIC2	23119	broad.mit.edu	37	22	21800594	21800594	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr22:21800594C>T	ENST00000443632.2	+	2	1782	c.1410C>T	c.(1408-1410)ttC>ttT	p.F470F	HIC2_ENST00000407464.2_Silent_p.F470F|HIC2_ENST00000407598.2_Silent_p.F470F			Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	470					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				AAGAGCTGTTCATCAAGGAAG	0.637000													12	37					0	0	0.000219431	0	0
CTC-260E6.6	0	broad.mit.edu	37	19	20369321	20369321	+	RNA	SNP	T	T	G			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr19:20369321T>G	ENST00000593655.1	-	0	199																											ACTACACATTTGGACCAGAGA	0.378000													54	73					0	0	0.000781405	0	0
SERPINB11	89778	broad.mit.edu	37	18	61383349	61383349	+	RNA	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr18:61383349G>A	ENST00000544088.1	+	0	500				SERPINB11_ENST00000382749.5_RNA|SERPINB11_ENST00000536691.1_RNA|SERPINB11_ENST00000538847.1_RNA|SERPINB11_ENST00000489748.1_RNA	NM_080475.2	NP_536723.2	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)						regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)|cervix(1)|kidney(1)|lung(3)	6		Esophageal squamous(42;0.129)				AAGAAACGAGGAAAACGATTA	0.358000													11	21					0	0	0.00010058	0	0
CELSR2	1952	broad.mit.edu	37	1	109806907	109806907	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:109806907C>G	ENST00000271332.3	+	10	5270	c.5209C>G	c.(5209-5211)Ctg>Gtg	p.L1737V		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	1737	Laminin G-like 2.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GCTGCATGGTCTGCACCTGAG	0.667000											OREG0013632	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	177	208					0	0	0.000781405	0	0
NRXN1	9378	broad.mit.edu	37	2	50170887	50170887	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr2:50170887C>T	ENST00000404971.1	-	23	5630	c.4291G>A	c.(4291-4293)Gat>Aat	p.D1431N	NRXN1_ENST00000401710.1_Missense_Mutation_p.D379N|NRXN1_ENST00000405472.3_Missense_Mutation_p.D1383N|NRXN1_ENST00000342183.5_Missense_Mutation_p.D326N|NRXN1_ENST00000402717.3_Missense_Mutation_p.D1383N|NRXN1_ENST00000401669.2_Missense_Mutation_p.D1391N|NRXN1_ENST00000406859.3_Missense_Mutation_p.D1361N|NRXN1_ENST00000406316.2_Missense_Mutation_p.D1361N	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	1361					adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TCCTCATCATCGCTGGGACAC	0.438000													14	21					0	0	0.000308642	0	0
ADGRG6	57211	broad.mit.edu	37	6	142721714	142721714	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr6:142721714T>C	ENST00000230173.6	+	11	2136	c.1660T>C	c.(1660-1662)Ttt>Ctt	p.F554L	GPR126_ENST00000367609.3_Missense_Mutation_p.F554L|GPR126_ENST00000367608.2_Missense_Mutation_p.F526L|GPR126_ENST00000296932.8_Missense_Mutation_p.F526L	NM_020455.5	NP_065188.4	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126	554					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(1)|kidney(3)|large_intestine(12)|lung(10)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		CAAGCCTGGCTTTTCTGCTTC	0.458000													6	20					0	0	8.12818e-05	0	0
MYT1L	23040	broad.mit.edu	37	2	1906872	1906872	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr2:1906872G>A	ENST00000399161.2	-	14	2759	c.2012C>T	c.(2011-2013)tCc>tTc	p.S671F	MYT1L_ENST00000428368.2_Missense_Mutation_p.S669F	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	671					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TCCTTTGGGGGATATATCCCT	0.428000													50	101					0	0	0.000781405	0	0
FMNL1	752	broad.mit.edu	37	17	43309832	43309832	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr17:43309832G>A	ENST00000331495.3	+	3	648	c.312G>A	c.(310-312)tgG>tgA	p.W104*	FMNL1_ENST00000328118.3_Nonsense_Mutation_p.W104*|FMNL1_ENST00000592006.1_3'UTR	NM_005892.3	NP_005883.2	O95466	FMNL_HUMAN	formin-like 1	104	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(12)|pancreas(1)|skin(1)|urinary_tract(2)	33						CAGCTGATTGGATGTCCAACC	0.527000													9	23					0	0	0.000673444	0	0
SH3BGR	6450	broad.mit.edu	37	21	40834351	40834351	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr21:40834351C>T	ENST00000333634.4	+	2	363	c.285C>T	c.(283-285)atC>atT	p.I95I	SH3BGR_ENST00000458295.1_5'UTR|SH3BGR_ENST00000380631.1_5'UTR|SH3BGR_ENST00000380637.3_5'UTR|SH3BGR_ENST00000380634.1_5'UTR	NM_007341.2	NP_031367.1	P55822	SH3BG_HUMAN	SH3 domain binding glutamic acid-rich protein	95					protein complex assembly	cytosol	SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(3)|lung(2)	8		all_cancers(19;1.16e-23)|all_epithelial(19;1.22e-20)|Prostate(19;2.55e-06)|Breast(209;0.0133)		STAD - Stomach adenocarcinoma(101;0.00151)		CGAATAAAATCGACTTTAAGG	0.368000													16	63					0	0	0.000132079	0	0
PDS5B	23047	broad.mit.edu	37	13	33333804	33333804	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr13:33333804G>C	ENST00000315596.10	+	29	3534	c.3348G>C	c.(3346-3348)atG>atC	p.M1116I		NM_015032.3	NP_055847.1	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	1116					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|lung(14)|ovary(5)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	62		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		CTCCTGAAATGAAATCATTTT	0.294000													12	44					0	0	0.000308642	0	0
OR8B8	26493	broad.mit.edu	37	11	124310904	124310904	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr11:124310904G>A	ENST00000328064.2	-	1	150	c.78C>T	c.(76-78)ccC>ccT	p.P26P		NM_012378.1	NP_036510.1	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B, member 8	26					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		GGAAGAAGAGGGGGATCTGGA	0.512000													7	40					0	0	0.000274275	0	0
OR5K4	403278	broad.mit.edu	37	3	98072744	98072744	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr3:98072744G>A	ENST00000354924.2	+	1	47	c.47G>A	c.(46-48)gGa>gAa	p.G16E	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005517.1	NP_001005517.1	A6NMS3	OR5K4_HUMAN	olfactory receptor, family 5, subfamily K, member 4	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(13)|upper_aerodigestive_tract(1)	21						ATCCTCATAGGATTTACAAAT	0.418000													15	49					0	0	0.000422831	0	0
PGC	5225	broad.mit.edu	37	6	41705561	41705561	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr6:41705561G>A	ENST00000373025.3	-	8	983	c.921C>T	c.(919-921)ctC>ctT	p.L307L		NM_002630.3	NP_002621.1	P20142	PEPC_HUMAN	progastricsin (pepsinogen C)	307					digestion|proteolysis	extracellular space	aspartic-type endopeptidase activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|skin(1)	16	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;0.000132)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			TACAGTTCACGAGAAACTGCA	0.532000													5	29					0	0	3.59834e-05	0	0
SMCHD1	23347	broad.mit.edu	37	18	2688411	2688411	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr18:2688411C>T	ENST00000320876.6	+	6	996	c.658C>T	c.(658-660)Cgt>Tgt	p.R220C	SMCHD1_ENST00000261598.8_Missense_Mutation_p.R220C	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	220					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						AGGATATGTTCGTCCAGTACC	0.373000													21	74					0	0	0.000375601	0	0
TP53BP1	7158	broad.mit.edu	37	15	43783950	43783950	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr15:43783950G>A	ENST00000263801.3	-	4	525	c.271_splice	c.e4-1	p.D91_splice	TP53BP1_ENST00000382039.3_Splice_Site_p.D96_splice|TP53BP1_ENST00000382044.4_Splice_Site_p.D96_splice|TP53BP1_ENST00000450115.2_Splice_Site_p.D96_splice	NM_005657.2	NP_005648.1	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1	91					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			breast(4)|endometrium(5)|kidney(7)|large_intestine(22)|lung(13)|ovary(4)|pancreas(2)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(3)	72		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		AATCCACAGGGTCTGAAAAAA	0.383000								Other conserved DNA damage response genes					50	74					0	0	0.000781405	0	0
LYST	1130	broad.mit.edu	37	1	235973516	235973516	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:235973516G>A	ENST00000389794.3	-	5	776	c.602C>T	c.(601-603)cCc>cTc	p.P201L	LYST_ENST00000389793.2_Missense_Mutation_p.P201L|LYST_ENST00000536965.1_Missense_Mutation_p.P201L			Q99698	LYST_HUMAN	lysosomal trafficking regulator	201					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TTTAGCTTTGGGGTGGTCTTG	0.423000													7	142					0	0	0.000157383	0	0
TBX15	6913	broad.mit.edu	37	1	119427402	119427402	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:119427402C>T	ENST00000369429.3	-	8	1771	c.1762G>A	c.(1762-1764)Ggg>Agg	p.G588R	TBX15_ENST00000207157.3_Missense_Mutation_p.G482R			Q96SF7	TBX15_HUMAN	T-box 15	588						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		GGAACTGCCCCATACTGCCGG	0.562000													40	56					0	0	0.000781405	0	0
VPS13D	55187	broad.mit.edu	37	1	12359295	12359295	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:12359295C>T	ENST00000358136.3	+	25	6200	c.6070C>T	c.(6070-6072)Ctg>Ttg	p.L2024L	VPS13D_ENST00000356315.4_Silent_p.L2024L	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	2024					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ACGGGTTCTCCTGGATATTGA	0.418000													42	45					0	0	0.000781405	0	0
PRB2	653247	broad.mit.edu	37	12	11546316	11546316	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr12:11546316G>A	ENST00000389362.4	-	3	731	c.696C>T	c.(694-696)tcC>tcT	p.S232S	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			GGGCACTTTGGGACTTGTTGT	0.602000													78	423					0	0	0.000781405	0	0
KRT20	54474	broad.mit.edu	37	17	39041305	39041305	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr17:39041305G>A	ENST00000167588.3	-	1	174	c.133C>T	c.(133-135)Cgc>Tgc	p.R45C		NM_019010.2	NP_061883.1	P35900	K1C20_HUMAN	keratin 20	45	Head.				apoptosis|intermediate filament organization	Golgi apparatus|intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|skin(1)	14		Breast(137;0.000301)|Ovarian(249;0.15)				TTGGAGATGCGGATGCCCCGG	0.597000													14	63					0	0	0.000422831	0	0
SLC6A20	54716	broad.mit.edu	37	3	45814059	45814059	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr3:45814059G>A	ENST00000358525.4	-	5	746	c.631C>T	c.(631-633)Ctc>Ttc	p.L211F	SLC6A20_ENST00000353278.4_Intron|SLC6A20_ENST00000456124.2_Missense_Mutation_p.L211F	NM_020208.3	NP_064593.1	Q9NP91	S6A20_HUMAN	solute carrier family 6 (proline IMINO transporter), member 20	211					cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|large_intestine(6)|ovary(2)|skin(2)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		CCCCTGATGAGGTAGATGATG	0.622000													7	22					0	0	0.000442599	0	0
N4BP2	55728	broad.mit.edu	37	4	40123006	40123006	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr4:40123006T>C	ENST00000261435.6	+	9	3691	c.3275T>C	c.(3274-3276)cTt>cCt	p.L1092P		NM_018177.4	NP_060647.2	Q86UW6	N4BP2_HUMAN	NEDD4 binding protein 2	1092						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			breast(4)|endometrium(3)|kidney(12)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	60						TCTGAAAATCTTAACATTCTT	0.348000													71	42					0	0	0.000781405	0	0
KCTD8	386617	broad.mit.edu	37	4	44177176	44177176	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr4:44177176G>A	ENST00000360029.3	-	2	1336	c.1053C>T	c.(1051-1053)tcC>tcT	p.S351S		NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	351						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						GCTCATTACAGGAAGTCCCAC	0.468000										HNSCC(17;0.042)			23	95					0	0	0.00047179	0	0
FAM179B	23116	broad.mit.edu	37	14	45433494	45433494	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr14:45433494T>A	ENST00000361462.2	+	1	2053	c.1870T>A	c.(1870-1872)Tgt>Agt	p.C624S	FAM179B_ENST00000361577.3_Missense_Mutation_p.C624S|KLHL28_ENST00000553817.1_Intron|FAM179B_ENST00000382233.2_Missense_Mutation_p.C624S			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	624							binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						GAGTGCACACTGTCACTGTGG	0.483000													13	35					0	0	0.00010058	0	0
DIP2A	23181	broad.mit.edu	37	21	47971611	47971611	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr21:47971611C>T	ENST00000318711.7	+	24	3090	c.2907C>T	c.(2905-2907)tcC>tcT	p.S969S	DIP2A_ENST00000427143.2_Silent_p.S904S|DIP2A_ENST00000417564.2_Silent_p.S968S|DIP2A_ENST00000400274.1_Silent_p.S964S	NM_001146116.1|NM_015151.3	NP_001139588.1|NP_055966.2	Q14689	DIP2A_HUMAN	DIP2 disco-interacting protein 2 homolog A (Drosophila)	968					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(22)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		CTCAGGCTTCCGGGAGAGAGC	0.622000													8	23					0	0	0.000673444	0	0
EYA1	2138	broad.mit.edu	37	8	72184075	72184075	+	Missense_Mutation	SNP	A	A	C	rs146687496		TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr8:72184075A>C	ENST00000340726.3	-	10	1523	c.884T>G	c.(883-885)tTg>tGg	p.L295W	EYA1_ENST00000419131.1_Missense_Mutation_p.L290W|EYA1_ENST00000388743.2_Missense_Mutation_p.L294W|EYA1_ENST00000388742.4_Missense_Mutation_p.L295W|EYA1_ENST00000388740.3_Missense_Mutation_p.L262W|EYA1_ENST00000388741.2_Missense_Mutation_p.L261W|EYA1_ENST00000303824.7_Missense_Mutation_p.L289W	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	295					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			ACCTCGACGCAATCGATCAGA	0.458000													62	141					0	0	0.000781405	0	0
STMN2	11075	broad.mit.edu	37	8	80553696	80553696	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr8:80553696G>A	ENST00000220876.7	+	3	581	c.199G>A	c.(199-201)Gcc>Acc	p.A67T	STMN2_ENST00000518111.1_Missense_Mutation_p.A67T|STMN2_ENST00000518491.1_Missense_Mutation_p.A56T	NM_001199214.1|NM_007029.3	NP_001186143.1|NP_008960.2	Q93045	STMN2_HUMAN	stathmin-like 2	67	Regulatory/phosphorylation domain (Potential).				intracellular signal transduction|negative regulation of microtubule depolymerization|negative regulation of microtubule polymerization|negative regulation of neuron projection development|neuron differentiation|positive regulation of microtubule depolymerization|positive regulation of neuron projection development	axon|growth cone|membrane|membrane fraction|perinuclear region of cytoplasm|soluble fraction	protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	11	all_lung(9;8.34e-05)		Epithelial(68;0.0229)|all cancers(69;0.0874)			TATCTCAGAAGCCCCACGAAC	0.453000													21	43					0	0	0.000229342	0	0
DAB1	1600	broad.mit.edu	37	1	57491655	57491655	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:57491655G>A	ENST00000371236.2	-	10	1048	c.786_splice	c.e10+1	p.P262_splice	DAB1_ENST00000420954.2_Splice_Site_p.P260_splice|DAB1_ENST00000371231.1_Splice_Site_p.P295_splice|DAB1_ENST00000439789.2_Splice_Site_p.P176_splice|DAB1_ENST00000414851.2_Splice_Site_p.P244_splice|DAB1_ENST00000485760.1_5'UTR|DAB1_ENST00000371234.4_Splice_Site_p.P262_splice			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	295					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						CATACTTACGGGGGGAGAGGT	0.458000													29	121					0	0	0.000692331	0	0
EEF2	1938	broad.mit.edu	37	19	3978042	3978042	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr19:3978042G>A	ENST00000309311.6	-	12	1930	c.1842C>T	c.(1840-1842)gcC>gcT	p.A614A		NM_001961.3	NP_001952.1	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2	614						cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity			endometrium(4)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		CGATGTCCTCGGCCAGGCCGT	0.647000													4	10					0	0	0.00024832	0	0
ANK3	288	broad.mit.edu	37	10	61802491	61802491	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr10:61802491C>T	ENST00000280772.1	-	43	13283	c.13092G>A	c.(13090-13092)acG>acA	p.T4364T	ANK3_ENST00000373827.2_Silent_p.T1848T|ANK3_ENST00000503366.1_Silent_p.T1855T|ANK3_ENST00000355288.2_Silent_p.T988T	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	4364					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTTCTTTCTTCGTTTTCACCT	0.398000													29	67					0	0	0.000227799	0	0
NOMO1	23420	broad.mit.edu	37	16	14968902	14968902	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr16:14968902C>T	ENST00000287667.7	+	19	2235	c.2064C>T	c.(2062-2064)atC>atT	p.I688I		NM_014287.3	NP_055102.3	Q15155	NOMO1_HUMAN	NODAL modulator 1	688						integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			endometrium(6)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|skin(2)	30						GGTCTTCCATCGACAGTGAAC	0.562000													29	80					0	0	0.000191422	0	0
SNX33	257364	broad.mit.edu	37	15	75941869	75941869	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr15:75941869C>T	ENST00000308527.5	+	1	1623	c.426C>T	c.(424-426)ccC>ccT	p.P142P		NM_153271.1	NP_695003.1	Q8WV41	SNX33_HUMAN	sorting nexin 33	142					cell communication		phosphatidylinositol binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|prostate(1)|soft_tissue(1)|urinary_tract(2)	19						GGCACCCTCCCCTCAACCTCT	0.647000													11	19					0	0	6.40141e-05	0	0
SNHG14	104472715	broad.mit.edu	37	15	25419962	25419962	+	RNA	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr15:25419962C>T	ENST00000549301.1	+	0	697				SNHG14_ENST00000441592.2_RNA																							ttcagcaggtccctccgtttg	0.488000													4	14					0	0	0.00024832	0	0
NRG3	10718	broad.mit.edu	37	10	84118519	84118519	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr10:84118519G>A	ENST00000372142.2	+	3	459	c.185G>A	c.(184-186)cGa>cAa	p.R62Q	NRG3_ENST00000556918.1_Missense_Mutation_p.R113Q|NRG3_ENST00000404547.1_Missense_Mutation_p.R283Q|NRG3_ENST00000404576.2_Missense_Mutation_p.R87Q|NRG3_ENST00000372141.2_Missense_Mutation_p.R283Q	NM_001165973.1	NP_001159445.1	P56975	NRG3_HUMAN	neuregulin 3	283					regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(41)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	69				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		TCCACAGAGCGATCCGAGCAC	0.517000													18	34					0	0	0.000958276	0	0
ZFHX4	79776	broad.mit.edu	37	8	77619807	77619807	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr8:77619807C>T	ENST00000521891.2	+	3	3065	c.2617C>T	c.(2617-2619)Cgg>Tgg	p.R873W	ZFHX4_ENST00000050961.6_Intron|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000455469.2_Intron|ZFHX4_ENST00000518282.1_Intron	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	863						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCCTGAAATCCGGCTTGCCAG	0.433000										HNSCC(33;0.089)			4	21					0	0	0.00024832	0	0
GPR158	57512	broad.mit.edu	37	10	25887683	25887683	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr10:25887683C>T	ENST00000376351.3	+	11	3487	c.3128C>T	c.(3127-3129)tCc>tTc	p.S1043F	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	1043						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						CCCACTTTTTCCTTAAAGGAG	0.453000													9	48					0	0	0.000274275	0	0
TNRC18	84629	broad.mit.edu	37	7	5348976	5348976	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:5348976G>A	ENST00000399537.4	-	28	8760	c.8412C>T	c.(8410-8412)gcC>gcT	p.A2804A	TNRC18_ENST00000430969.1_Silent_p.A2804A			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2804							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		AGAGCTTGCGGGCCTTGCCCT	0.672000													8	19					0	0	0.000274275	0	0
HSPB3	8988	broad.mit.edu	37	5	53751781	53751781	+	Silent	SNP	T	T	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr5:53751781T>A	ENST00000302005.1	+	1	337	c.162T>A	c.(160-162)ccT>ccA	p.P54P		NM_006308.2	NP_006299.1	Q12988	HSPB3_HUMAN	heat shock 27kDa protein 3	54					cell death|response to heat|response to unfolded protein	cytoplasm|nucleus				breast(1)|large_intestine(4)|prostate(3)	8		Lung NSC(810;0.00104)				CGCAGTCTCCTCCAGTGGACT	0.562000													75	25					0	0	0.000781405	0	0
CNTN6	27255	broad.mit.edu	37	3	1424655	1424655	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr3:1424655G>A	ENST00000446702.2	+	18	2823	c.2196G>A	c.(2194-2196)gaG>gaA	p.E732E	CNTN6_ENST00000539053.1_Silent_p.E660E|CNTN6_ENST00000350110.2_Silent_p.E732E			Q9UQ52	CNTN6_HUMAN	contactin 6	732	Fibronectin type-III 2.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		AGAATGGGGAGGGATTTGGAT	0.398000													8	52					0	0	0.000442599	0	0
KRT5	3852	broad.mit.edu	37	12	52913579	52913579	+	Missense_Mutation	SNP	C	C	T	rs58619430		TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr12:52913579C>T	ENST00000252242.4	-	1	892	c.502G>A	c.(502-504)Gag>Aag	p.E168K		NM_000424.3	NP_000415.2	P13647	K2C5_HUMAN	keratin 5	168	Coil 1A.|Rod.		E -> K (in DM-EBS; dbSNP:rs58619430).		epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(5)|kidney(1)|large_intestine(8)|lung(15)|prostate(4)|skin(2)	35				BRCA - Breast invasive adenocarcinoma(357;0.189)		TGCTCGCGCTCCTCGGTCCTC	0.507000													52	80					0	0	0.000781405	0	0
IKBKAP	8518	broad.mit.edu	37	9	111641823	111641823	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr9:111641823G>A	ENST00000374647.5	-	33	3782	c.3475C>T	c.(3475-3477)Cac>Tac	p.H1159Y	IKBKAP_ENST00000467959.1_5'UTR|IKBKAP_ENST00000537196.1_Missense_Mutation_p.H810Y	NM_003640.3	NP_003631.2	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	1159					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			NS(2)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						TCTTGCCCGTGGGGTACCTCA	0.468000													8	26					0	0	0.000274275	0	0
ASTN1	460	broad.mit.edu	37	1	176853551	176853551	+	Silent	SNP	G	G	A	rs150457018		TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:176853551G>A	ENST00000367654.2	-	19	3187	c.3174C>T	c.(3172-3174)atC>atT	p.I1058I	ASTN1_ENST00000367657.3_Silent_p.I1050I|ASTN1_ENST00000424564.2_Silent_p.I1050I|ASTN1_ENST00000361833.2_Silent_p.I1050I			O14525	ASTN1_HUMAN	astrotactin 1	1058	Fibronectin type-III 1.				cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						TCTGCACCCCGATTGGTGGCT	0.547000													21	71					0	0	0.000175454	0	0
NID1	4811	broad.mit.edu	37	1	236143950	236143950	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:236143950G>A	ENST00000264187.6	-	17	3313	c.3231C>T	c.(3229-3231)aaC>aaT	p.N1077N	NID1_ENST00000366595.3_Silent_p.N944N	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	1077					cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	TCCAGTAAAGGTTCCTGGAGG	0.433000													25	29					0	0	0.000227799	0	0
DNER	92737	broad.mit.edu	37	2	230377642	230377642	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr2:230377642G>A	ENST00000341772.4	-	6	1138	c.1004C>T	c.(1003-1005)tCc>tTc	p.S335F		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	335	EGF-like 3.				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		ACAGGTACAGGAAAAAGTTGC	0.438000													13	28					0	0	0.000151284	0	0
ALPK1	80216	broad.mit.edu	37	4	113356441	113356441	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr4:113356441G>A	ENST00000458497.1	+	12	3451	c.3172G>A	c.(3172-3174)Gaa>Aaa	p.E1058K	ALPK1_ENST00000177648.9_Missense_Mutation_p.E1058K|ALPK1_ENST00000504176.2_Missense_Mutation_p.E980K	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	1058	Alpha-type protein kinase.						ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		TCTTCATCAAGAAGAAATTCT	0.378000													79	148					0	0	0.000781405	0	0
MUC17	140453	broad.mit.edu	37	7	100675855	100675855	+	Silent	SNP	A	A	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:100675855A>C	ENST00000306151.4	+	3	1222	c.1158A>C	c.(1156-1158)tcA>tcC	p.S386S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	386	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TGCTAACCTCAACTCTTAGTG	0.458000													20	347					0	0	0.000132079	0	0
TMPRSS9	360200	broad.mit.edu	37	19	2408579	2408579	+	Silent	SNP	C	C	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr19:2408579C>A	ENST00000332578.3	+	7	966	c.966C>A	c.(964-966)ccC>ccA	p.P322P		NM_182973.1	NP_892018.1	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	322	Peptidase S1 1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTTCCCACCCAGCAAGAAGT	0.627000													6	68					0.000157383	0.0019075	0.000157383	1	0
ZSWIM3	140831	broad.mit.edu	37	20	44506018	44506018	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr20:44506018C>T	ENST00000255152.2	+	2	1030	c.821C>T	c.(820-822)tCc>tTc	p.S274F	ZSWIM3_ENST00000454862.2_Missense_Mutation_p.S268F	NM_080752.3	NP_542790.2	Q96MP5	ZSWM3_HUMAN	zinc finger, SWIM-type containing 3	274							zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	35		Myeloproliferative disorder(115;0.0122)				GAGTTCAACTCCGATTGGCCC	0.532000													27	35					0	0	0.000878237	0	0
NCOR2	9612	broad.mit.edu	37	12	124841297	124841297	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr12:124841297C>T	ENST00000356219.3	-	24	3308	c.3153G>A	c.(3151-3153)ggG>ggA	p.G1051G	NCOR2_ENST00000429285.2_Silent_p.G1034G|NCOR2_ENST00000405201.1_Silent_p.G1044G|NCOR2_ENST00000404621.1_Silent_p.G1034G|NCOR2_ENST00000404121.2_Silent_p.G605G|NCOR2_ENST00000397355.1_Silent_p.G1035G	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	1052					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		AAGGGGGGTCCCCAGGCAGCT	0.692000													5	6					0	0	0.000602214	0	0
MDH2	4191	broad.mit.edu	37	7	75686799	75686799	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:75686799C>T	ENST00000315758.5	+	3	401	c.307C>T	c.(307-309)Ccc>Tcc	p.P103S	MDH2_ENST00000432020.2_Missense_Mutation_p.P103S|MDH2_ENST00000443006.1_5'UTR	NM_005918.2	NP_005909.2	P40926	MDHM_HUMAN	malate dehydrogenase 2, NAD (mitochondrial)	103					gluconeogenesis|malate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus|plasma membrane	binding|L-malate dehydrogenase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|skin(2)	14					NADH(DB00157)	GGCTGGAGTCCCCAGAAAGCC	0.468000													27	29					0	0	0.000339439	0	0
ADNP	23394	broad.mit.edu	37	20	49509856	49509856	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr20:49509856G>A	ENST00000396029.3	-	5	1962	c.1395C>T	c.(1393-1395)ttC>ttT	p.F465F	ADNP_ENST00000396032.3_Silent_p.F465F|ADNP_ENST00000371602.4_Silent_p.F465F|ADNP_ENST00000349014.3_Silent_p.F465F	NM_015339.2	NP_056154.1	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector homeobox	465						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.F465F(1)		NS(1)|breast(4)|endometrium(7)|kidney(1)|large_intestine(13)|lung(7)|ovary(2)|prostate(2)|skin(2)	39						GTTCTTTTTCGAAGTGCACAC	0.388000													79	198					0	0	0.000781405	0	0
IL1R1	3554	broad.mit.edu	37	2	102781300	102781300	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr2:102781300C>T	ENST00000410023.1	+	4	446	c.128C>T	c.(127-129)cCc>cTc	p.P43L	IL1R1_ENST00000233946.3_Missense_Mutation_p.P43L|IL1R1_ENST00000409589.1_Missense_Mutation_p.P43L|IL1R1_ENST00000409288.1_Missense_Mutation_p.P43L|IL1R1_ENST00000424272.1_Missense_Mutation_p.P43L|IL1R1_ENST00000409329.1_Missense_Mutation_p.P43L|IL1R1_ENST00000409929.1_Missense_Mutation_p.P43L			P14778	IL1R1_HUMAN	interleukin 1 receptor, type I	43	Ig-like C2-type 1.				innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity|platelet-derived growth factor receptor binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|prostate(2)|skin(3)	19					Anakinra(DB00026)	GATGTTCGTCCCTGTCCTCTT	0.368000													22	57					0	0	0.000878237	0	0
LSM10	84967	broad.mit.edu	37	1	36859386	36859386	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:36859386C>T	ENST00000315732.2	-	2	494	c.345G>A	c.(343-345)tgG>tgA	p.W115*	LSM10_ENST00000476041.1_5'UTR	NM_032881.1	NP_116270.1	Q969L4	LSM10_HUMAN	LSM10, U7 small nuclear RNA associated	115					histone mRNA metabolic process|mRNA processing|RNA splicing|S phase of mitotic cell cycle|termination of RNA polymerase II transcription	Cajal body|U7 snRNP	histone pre-mRNA DCP binding|protein binding			upper_aerodigestive_tract(1)|urinary_tract(1)	2		Myeloproliferative disorder(586;0.0393)				GGGGAAATTCCCACCGGCCTT	0.572000													13	69					0	0	0.00010058	0	0
SSTR5	6755	broad.mit.edu	37	16	1128917	1128917	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr16:1128917C>T	ENST00000293897.4	+	1	137	c.49C>T	c.(49-51)Ccg>Tcg	p.P17S	SSTR5_ENST00000562758.1_Missense_Mutation_p.P17S|SSTR5_ENST00000397547.2_Missense_Mutation_p.P17S	NM_001053.3	NP_001044.1	P35346	SSR5_HUMAN	somatostatin receptor 5	17					negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			endometrium(2)|lung(5)|prostate(1)|skin(1)	9		Hepatocellular(780;0.00369)			Octreotide(DB00104)	CGCCTCCTCCCCGGGGGCTGC	0.726000													4	4					0	0	0.000602214	0	0
LGALS12	85329	broad.mit.edu	37	11	63279257	63279257	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr11:63279257C>T	ENST00000415491.2	+	6	1089	c.475C>T	c.(475-477)Ctc>Ttc	p.L159F	LGALS12_ENST00000425950.2_Missense_Mutation_p.L150F|LGALS12_ENST00000340246.5_Missense_Mutation_p.L221F|LGALS12_ENST00000255684.5_Missense_Mutation_p.L211F|LGALS12_ENST00000394618.3_Missense_Mutation_p.L220F	NM_001142537.1	NP_001136009.1	Q96DT0	LEG12_HUMAN	lectin, galactoside-binding, soluble, 12	220	Galectin 1.				apoptosis|induction of apoptosis by intracellular signals	nucleus	lactose binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	16						TCCCCAGGGTCTCTCGCCTGG	0.592000													20	30					0	0	0.00047179	0	0
ABCC3	8714	broad.mit.edu	37	17	48757215	48757215	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr17:48757215C>T	ENST00000285238.8	+	26	3842	c.3762C>T	c.(3760-3762)atC>atT	p.I1254I		NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	1254					bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	AATCTAACATCGTGGCTGTGG	0.522000													23	46					0	0	0.000586117	0	0
PRSS12	8492	broad.mit.edu	37	4	119256736	119256736	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr4:119256736G>A	ENST00000296498.3	-	3	994	c.712C>T	c.(712-714)Cgt>Tgt	p.R238C		NM_003619.3	NP_003610.2	P56730	NETR_HUMAN	protease, serine, 12 (neurotrypsin, motopsin)	238	SRCR 1.					membrane	scavenger receptor activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(11)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	29						CCTCGGCAACGGACATTGCTC	0.453000													30	73					0	0	0.000491102	0	0
SPZ1	84654	broad.mit.edu	37	5	79616163	79616163	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr5:79616163C>T	ENST00000296739.4	+	1	374	c.129C>T	c.(127-129)tcC>tcT	p.S43S		NM_032567.3	NP_115956.3	Q9BXG8	SPZ1_HUMAN	spermatogenic leucine zipper 1	43					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			endometrium(2)|kidney(5)|large_intestine(4)|lung(12)|ovary(1)|skin(2)	26		Lung NSC(167;0.0393)|all_lung(232;0.0428)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;3.43e-47)|Epithelial(54;2.25e-41)|all cancers(79;4.19e-36)		GATCACATTCCCCTTCCTCCT	0.428000													20	124					0	0	0.000175454	0	0
PPP1R10	5514	broad.mit.edu	37	6	30572382	30572382	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr6:30572382G>A	ENST00000376511.2	-	12	1637	c.1085C>T	c.(1084-1086)cCg>cTg	p.P362L		NM_002714.3	NP_002705.2	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	362					protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(1)	25						CATGAGCTCCGGGACTTCAAC	0.542000													44	197					0	0	0.000781405	0	0
KRT20	54474	broad.mit.edu	37	17	39041306	39041306	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr17:39041306G>A	ENST00000167588.3	-	1	173	c.132C>T	c.(130-132)atC>atT	p.I44I		NM_019010.2	NP_061883.1	P35900	K1C20_HUMAN	keratin 20	44	Head.				apoptosis|intermediate filament organization	Golgi apparatus|intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|skin(1)	14		Breast(137;0.000301)|Ovarian(249;0.15)				TGGAGATGCGGATGCCCCGGC	0.602000													15	61					0	0	0.000566183	0	0
PARP9	83666	broad.mit.edu	37	3	122269585	122269585	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr3:122269585G>A	ENST00000462315.1	-	6	1465	c.1172C>T	c.(1171-1173)tCc>tTc	p.S391F	PARP9_ENST00000360356.2_Missense_Mutation_p.S426F|PARP9_ENST00000492382.1_Intron|PARP9_ENST00000471785.1_Missense_Mutation_p.S391F|PARP9_ENST00000477522.2_Missense_Mutation_p.S391F	NM_001146106.1	NP_001139578.1	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	426	Macro 2.				cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(3)	34				GBM - Glioblastoma multiforme(114;0.0519)		GGCAGGAAAGGAAATGGAAGT	0.348000													14	27					0	0	0.00074312	0	0
MAPK12	6300	broad.mit.edu	37	22	50693885	50693885	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr22:50693885G>C	ENST00000215659.8	-	10	1162	c.847C>G	c.(847-849)Ctg>Gtg	p.L283V	MAPK12_ENST00000395780.1_Missense_Mutation_p.L193V|MAPK12_ENST00000497036.1_5'UTR	NM_002969.3	NP_002960.2	P53778	MK12_HUMAN	mitogen-activated protein kinase 12	283	Protein kinase.				cell cycle arrest|DNA damage induced protein phosphorylation|muscle organ development|myoblast differentiation|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction	mitochondrion|nucleoplasm	ATP binding|magnesium ion binding|MAP kinase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|skin(1)	8		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCCGTACCCAGAGGGCTTGCA	0.612000													24	28					0	0	0.000720815	0	0
CLEC14A	161198	broad.mit.edu	37	14	38724651	38724651	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr14:38724651G>A	ENST00000342213.2	-	1	923	c.577C>T	c.(577-579)Cgc>Tgc	p.R193C		NM_175060.2	NP_778230.1	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	193						integral to membrane	sugar binding	p.R193C(1)		breast(1)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		AAGGGCGCGCGATAGCTCAAG	0.647000													20	26					0	0	0.000958276	0	0
MUC16	94025	broad.mit.edu	37	19	9085156	9085156	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr19:9085156G>T	ENST00000397910.4	-	1	6862	c.6659C>A	c.(6658-6660)cCa>cAa	p.P2220Q		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2220	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCTGTTTACTGGGATGCTTGT	0.468000													9	48					0.000442599	0.00533455	0.000442599	1	0
SEPT7	989	broad.mit.edu	37	7	35930362	35930362	+	Silent	SNP	T	T	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:35930362T>C	ENST00000494488.2	+	10	915	c.915T>C	c.(913-915)taT>taC	p.Y305Y	SEPT7_ENST00000432293.2_Intron|SEPT7_ENST00000399034.2_Silent_p.Y320Y|SEPT7_ENST00000435235.1_Silent_p.Y266Y|SEPT7_ENST00000399035.3_Silent_p.Y318Y|SEPT7_ENST00000350320.6_Silent_p.Y318Y			Q16181	SEPT7_HUMAN	septin 7	319					cilium morphogenesis|cytokinesis|mitosis|protein heterooligomerization|regulation of embryonic cell shape	cilium axoneme|cleavage furrow|condensed chromosome kinetochore|midbody|nucleus|septin complex|spindle|stress fiber	GTP binding|protein binding|structural molecule activity	p.Y320Y(3)		central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)	14						CTGTGACTTATAATGGAGTTG	0.323000													4	66					0	0	0.00024832	0	0
SOGA2	23255	broad.mit.edu	37	18	8826060	8826060	+	Silent	SNP	T	T	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr18:8826060T>C	ENST00000359865.3	+	15	4694	c.4552T>C	c.(4552-4554)Tta>Cta	p.L1518L	SOGA2_ENST00000518815.1_Silent_p.L843L|SOGA2_ENST00000306329.11_Silent_p.L1837L|SOGA2_ENST00000306285.7_Silent_p.L843L|SOGA2_ENST00000517570.1_Silent_p.L1477L|SOGA2_ENST00000400050.3_Silent_p.L1477L	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	1828																	GAAGCAGGACTTATCTGCTCC	0.602000													3	9					0	0	6.4e-05	0	0
ELAVL4	1996	broad.mit.edu	37	1	50572027	50572027	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:50572027G>A	ENST00000357083.4	+	1	64	c.22G>A	c.(22-24)Gaa>Aaa	p.E8K	ELAVL4_ENST00000448907.2_Intron|ELAVL4_ENST00000371827.1_Intron	NM_001144775.1	NP_001138247.1	P26378	ELAV4_HUMAN	ELAV like neuron-specific RNA binding protein 4	0					mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			NS(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	32						TCTTTTAAGGGAAATTGTCAT	0.473000													12	21					0	0	0.000219431	0	0
SUPV3L1	6832	broad.mit.edu	37	10	70958868	70958868	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr10:70958868C>T	ENST00000359655.4	+	10	1273	c.1213C>T	c.(1213-1215)Ctt>Ttt	p.L405F		NM_003171.3	NP_003162.2	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 (S. cerevisiae)	405	Helicase C-terminal.				DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						AGGGACCAAACTTGCTCAAGC	0.353000													15	31					0	0	0.000308642	0	0
FXYD6	53826	broad.mit.edu	37	11	117711882	117711882	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr11:117711882T>C	ENST00000526014.1	-	5	785	c.190A>G	c.(190-192)Agt>Ggt	p.S64G	FXYD6_ENST00000260282.4_Missense_Mutation_p.S64G|FXYD6_ENST00000524656.1_Missense_Mutation_p.S64G|FXYD6_ENST00000583233.1_5'UTR|FXYD6_ENST00000540359.1_Missense_Mutation_p.S64G|FXYD6_ENST00000539526.1_Missense_Mutation_p.S64G|FXYD6-FXYD2_ENST00000532984.1_Intron|FXYD6_ENST00000530956.1_Missense_Mutation_p.S64G|FXYD6_ENST00000527717.1_Missense_Mutation_p.S64G|FXYD6_ENST00000529335.2_Missense_Mutation_p.S63G|FXYD6_ENST00000527429.1_Missense_Mutation_p.S64G|FXYD6_ENST00000584394.1_Missense_Mutation_p.S64G|FXYD6_ENST00000584230.1_Missense_Mutation_p.S64G	NM_022003.3	NP_071286.1			FXYD domain containing ion transport regulator 6											central_nervous_system(1)|large_intestine(5)|lung(1)|skin(1)	8	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|Breast(348;0.111)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.89e-05)|Epithelial(105;0.00122)		TGATTGAAACTGCACTTGCAC	0.577000													9	19					0	0	0.00010058	0	0
MICALL1	85377	broad.mit.edu	37	22	38323801	38323801	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr22:38323801C>T	ENST00000215957.6	+	9	1975	c.1849C>T	c.(1849-1851)Cct>Tct	p.P617S	MICALL1_ENST00000402631.1_3'UTR	NM_033386.3	NP_203744.1	Q8N3F8	MILK1_HUMAN	MICAL-like 1	617	Pro-rich.					cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	24	Melanoma(58;0.045)					GGTGCCTTCCCCTGGAAGCTC	0.632000													31	37					0	0	0.00058488	0	0
TRIM58	25893	broad.mit.edu	37	1	248039677	248039677	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:248039677C>T	ENST00000366481.3	+	6	1395	c.1347C>T	c.(1345-1347)ttC>ttT	p.F449F	OR2W3_ENST00000537741.1_Intron	NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	449	B30.2/SPRY.					intracellular	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CTTACTTTTTCATCTGTGATG	0.423000													53	56					0	0	0.000781405	0	0
IGKV1-17	28937	broad.mit.edu	37	2	89417258	89417258	+	RNA	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr2:89417258G>A	ENST00000490686.1	-	0	77																											CCTTACCTGGGAACCAGAGCA	0.507000													8	209					0	0	0.000673444	0	0
MSANTD4	84437	broad.mit.edu	37	11	105880595	105880595	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr11:105880595G>A	ENST00000301919.4	-	3	2120	c.705C>T	c.(703-705)atC>atT	p.I235I		NM_032424.1	NP_115800.1	Q8NCY6	K1826_HUMAN	Myb/SANT-like DNA-binding domain containing 4 with coiled-coils	235						nucleus											TCTCTTTCTCGATTTGTAGGC	0.453000													36	67					0	0	0.000191422	0	0
RPS11	6205	broad.mit.edu	37	19	50001293	50001293	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr19:50001293C>T	ENST00000270625.2	+	4	426	c.343C>T	c.(343-345)Ccc>Tcc	p.P115S	RPS11_ENST00000594493.1_Missense_Mutation_p.P36S|RPS11_ENST00000596873.1_Missense_Mutation_p.P115S|RPS11_ENST00000599561.1_Missense_Mutation_p.P80L	NM_001015.4	NP_001006.1	P62280	RS11_HUMAN	ribosomal protein S11	115					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|rRNA binding|structural constituent of ribosome			kidney(1)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	7		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00206)|GBM - Glioblastoma multiforme(486;0.0245)		ACACCTGTCCCCCTGCTTCAG	0.557000													12	41					0	0	0.000219431	0	0
TNRC18	84629	broad.mit.edu	37	7	5348975	5348975	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:5348975G>A	ENST00000399537.4	-	28	8761	c.8413C>T	c.(8413-8415)Cgc>Tgc	p.R2805C	TNRC18_ENST00000430969.1_Missense_Mutation_p.R2805C			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2805							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		AAGAGCTTGCGGGCCTTGCCC	0.672000													8	19					0	0	0.000274275	0	0
LRMP	4033	broad.mit.edu	37	12	25243071	25243071	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr12:25243071C>T	ENST00000354454.3	+	13	1375	c.546C>T	c.(544-546)tcC>tcT	p.S182S	LRMP_ENST00000547044.1_Silent_p.S182S|LRMP_ENST00000548766.1_Silent_p.S182S	NM_006152.3	NP_006143.2	Q12912	LRMP_HUMAN	lymphoid-restricted membrane protein	238					vesicle fusion|vesicle targeting	endoplasmic reticulum membrane|integral to plasma membrane				breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Colorectal(261;0.11)					AAGAGAGGTCCCGTGACTTGG	0.363000													145	44					0	0	0.000781405	0	0
IGKV1D-17	28900	broad.mit.edu	37	2	90121708	90121708	+	RNA	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr2:90121708C>T	ENST00000483379.1	+	0	232																											TGCTCTGGTTCCCAGGTAAGG	0.498000													28	61					0	0	0.000339439	0	0
TANC1	85461	broad.mit.edu	37	2	160007007	160007007	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr2:160007007C>T	ENST00000263635.6	+	7	859	c.622C>T	c.(622-624)Ccc>Tcc	p.P208S	TANC1_ENST00000454300.1_Intron	NM_001145909.1|NM_033394.2	NP_001139381.1|NP_203752.2	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	208	Ser-rich.					cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						CAACAAAAGTCCCTGTGAGAC	0.507000													22	34					0	0	0.00047179	0	0
CCDC8	83987	broad.mit.edu	37	19	46914505	46914505	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr19:46914505C>T	ENST00000307522.3	-	1	2336	c.1563G>A	c.(1561-1563)ctG>ctA	p.L521L		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	521						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		CCTCGGCCCTCAGCACCCTGA	0.647000													9	61					0	0	0.000442599	0	0
RGMB	285704	broad.mit.edu	37	5	98115338	98115338	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr5:98115338T>A	ENST00000308234.7	+	4	716	c.314T>A	c.(313-315)gTg>gAg	p.V105E	RGMB_ENST00000513185.1_Missense_Mutation_p.V64E|RGMB_ENST00000504776.1_3'UTR	NM_001012761.2	NP_001012779.2	Q6NW40	RGMB_HUMAN	repulsive guidance molecule family member b	64					axon guidance|BMP signaling pathway|cell adhesion|positive regulation of transcription, DNA-dependent	anchored to plasma membrane|ER-Golgi intermediate compartment|membrane raft	identical protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(2)|upper_aerodigestive_tract(1)	10		all_cancers(142;2.76e-08)|all_epithelial(76;2.98e-11)|all_lung(232;0.000485)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0587)		ACGGACTTCGTGTCCCTGACT	0.493000													74	115					0	0	0.000781405	0	0
ERG	2078	broad.mit.edu	37	21	39774506	39774506	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr21:39774506G>T	ENST00000442448.1	-	7	938	c.667C>A	c.(667-669)Cca>Aca	p.P223T	ERG_ENST00000398907.1_Missense_Mutation_p.P216T|ERG_ENST00000398911.1_Missense_Mutation_p.P223T|ERG_ENST00000288319.7_Missense_Mutation_p.P216T|ERG_ENST00000398919.2_Missense_Mutation_p.P223T|ERG_ENST00000429727.2_Intron|ERG_ENST00000398905.1_Missense_Mutation_p.P216T|ERG_ENST00000453032.2_Missense_Mutation_p.P124T|ERG_ENST00000398910.1_Missense_Mutation_p.P223T|ERG_ENST00000417133.2_Missense_Mutation_p.P223T|ERG_ENST00000398897.1_Missense_Mutation_p.P124T	NM_004449.4	NP_004440.1	P11308	ERG_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog	223					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		EWSR1/ERG(178)|NDRG1/ERG(5)|TMPRSS2/ERG(3582)|FUS/ERG(167)|SLC45A3/ERG(50)	lung(2)|ovary(1)|skin(1)	4		Prostate(19;3.6e-06)				ATTAACCGTGGAGAGTTTTGT	0.438000			T	"""EWSR1, TMPRSS2, ELF4, FUS, HERPUD1, NDRG1"""	"""Ewing sarcoma, prostate, AML"""								14	37					2.23348e-06	2.75315e-05	0.000422831	1	0
VWC2	375567	broad.mit.edu	37	7	49842382	49842382	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:49842382G>A	ENST00000340652.3	+	3	1328	c.772G>A	c.(772-774)Gag>Aag	p.E258K		NM_198570.3	NP_940972.2	Q2TAL6	VWC2_HUMAN	von Willebrand factor C domain containing 2	258	VWFC 2.				negative regulation of BMP signaling pathway|positive regulation of neuron differentiation	basement membrane|extracellular space				cervix(1)|endometrium(2)|large_intestine(1)|lung(3)|prostate(1)	8						TCCCCAGACGGAGTGTGTGGA	0.567000													11	104					0	0	0.00010058	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				56	50					0	0	0.000781405	0	0
DNAH11	8701	broad.mit.edu	37	7	21934243	21934243	+	Silent	SNP	T	T	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:21934243T>A	ENST00000328843.6	+	79	12805	c.12774T>A	c.(12772-12774)gtT>gtA	p.V4258V	DNAH11_ENST00000409508.3_Silent_p.V4251V			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	4258					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						GATTTAAGGTTAAGAATGTCT	0.328000									Kartagener syndrome				24	102					0	0	0.00047179	0	0
TXNDC2	84203	broad.mit.edu	37	18	9888079	9888079	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr18:9888079G>A	ENST00000306084.6	+	2	1802	c.1603G>A	c.(1603-1605)Gat>Aat	p.D535N	TXNDC2_ENST00000577697.1_3'UTR|TXNDC2_ENST00000536353.2_3'UTR|TXNDC2_ENST00000357775.4_Missense_Mutation_p.D468N	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	535	Thioredoxin.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						AGAAAAGGTGGATGAACTTTG	0.428000													13	10					0	0	0.000151284	0	0
XKR5	389610	broad.mit.edu	37	8	6682798	6682798	+	RNA	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr8:6682798C>T	ENST00000518724.1	-	0	466							Q6UX68	XKR5_HUMAN	XK, Kell blood group complex subunit-related family, member 5							integral to membrane				endometrium(1)|large_intestine(1)|lung(1)	3			STAD - Stomach adenocarcinoma(24;0.0984)	READ - Rectum adenocarcinoma(644;0.137)|COAD - Colon adenocarcinoma(149;0.166)		AGGTCGGCCTCCTGCAGCTGC	0.612000													8	19					0	0	0.000157383	0	0
CPXM1	56265	broad.mit.edu	37	20	2777035	2777035	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr20:2777035C>T	ENST00000380605.2	-	9	1164	c.1100G>A	c.(1099-1101)cGg>cAg	p.R367Q		NM_001184699.1|NM_019609.4	NP_001171628.1|NP_062555.1	Q96SM3	CPXM1_HUMAN	carboxypeptidase X (M14 family), member 1	367					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(8)|lung(17)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						AAGCAACTCCCGCCCCAGGGC	0.652000													16	63					0	0	0.00074312	0	0
NUTM1	256646	broad.mit.edu	37	15	34640410	34640410	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr15:34640410G>A	ENST00000537011.1	+	3	723	c.341G>A	c.(340-342)gGc>gAc	p.G114D	NUTM1_ENST00000438749.3_Missense_Mutation_p.G104D|NUTM1_ENST00000333756.4_Missense_Mutation_p.G86D					NUT midline carcinoma, family member 1																		GCTGGGGCTGGCAAGGTCATT	0.557000													15	39					0	0	0.000219431	0	0
MB	4151	broad.mit.edu	37	22	36003387	36003387	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr22:36003387T>G	ENST00000397326.2	-	3	620	c.422A>C	c.(421-423)aAg>aCg	p.K141T	MB_ENST00000397328.1_Missense_Mutation_p.K141T|MB_ENST00000406324.1_Missense_Mutation_p.K141T|MB_ENST00000359787.1_Missense_Mutation_p.K141T|MB_ENST00000401702.1_Missense_Mutation_p.K86T	NM_005368.2	NP_005359.1	P02144	MYG_HUMAN	myoglobin	141							heme binding|oxygen transporter activity			lung(1)	1						GGCCATGTCCTTCCGGAACAG	0.632000													15	34					0	0	0.000422831	0	0
RBM42	79171	broad.mit.edu	37	19	36128163	36128163	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr19:36128163C>T	ENST00000262633.4	+	9	1344	c.1239C>T	c.(1237-1239)atC>atT	p.I413I	RBM42_ENST00000589871.1_Silent_p.I391I|RBM42_ENST00000589559.1_Intron|RBM42_ENST00000592202.1_Silent_p.I359I|RBM42_ENST00000586618.1_Silent_p.I117I|RBM42_ENST00000588161.1_Silent_p.I383I|RBM42_ENST00000360475.4_Silent_p.I384I	NM_024321.3	NP_077297.2	Q9BTD8	RBM42_HUMAN	RNA binding motif protein 42	413	Necessary for interaction with HNRNPK (By similarity).|RRM.					cytoplasm|nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(3)|large_intestine(7)|lung(9)|prostate(1)	21	all_lung(56;1.58e-07)|Lung NSC(56;2.43e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CCAAGGTGATCCGTGACAAGC	0.587000													6	57					0	0	8.12818e-05	0	0
PSKH2	85481	broad.mit.edu	37	8	87076413	87076413	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr8:87076413C>T	ENST00000276616.2	-	2	707	c.633G>A	c.(631-633)ggG>ggA	p.G211G	PSKH2_ENST00000517981.1_5'UTR	NM_033126.1	NP_149117.1	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	211	Protein kinase.		G -> R (in dbSNP:rs36074412).				ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|kidney(11)|large_intestine(2)|lung(26)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(1)	47			STAD - Stomach adenocarcinoma(118;0.129)			CACTTTTTTTCCCGGAGTATG	0.418000													5	54					0	0	0.000602214	0	0
PPRC1	23082	broad.mit.edu	37	10	103906857	103906857	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr10:103906857C>G	ENST00000278070.2	+	9	4147	c.4108C>G	c.(4108-4110)Ctt>Gtt	p.L1370V	PPRC1_ENST00000370012.1_Missense_Mutation_p.L337V|PPRC1_ENST00000489648.1_Intron|PPRC1_ENST00000413464.2_Intron	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	1370					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		AGCACCCTGCCTTGCCCCATC	0.642000													6	14					0	0	3.59834e-05	0	0
SGK494	124923	broad.mit.edu	37	17	26938597	26938597	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr17:26938597G>A	ENST00000301037.5	-	9	798	c.799C>T	c.(799-801)Ctt>Ttt	p.L267F	SPAG5-AS1_ENST00000554154.1_RNA|RP11-192H23.4_ENST00000534850.1_3'UTR|RP11-192H23.4_ENST00000577790.1_Intron	NM_001174103.1	NP_001167574.1																					ATGTACTGAAGAGTGCCACAG	0.493000													63	113					0	0	0.000781405	0	0
TMEM184A	202915	broad.mit.edu	37	7	1595015	1595015	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:1595015C>T	ENST00000297477.5	-	2	422	c.106G>A	c.(106-108)Gac>Aac	p.D36N		NM_001097620.1	NP_001091089.1	Q6ZMB5	T184A_HUMAN	transmembrane protein 184A	36						integral to membrane				endometrium(1)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	12		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.88e-15)		CCCATGTGGTCCATCTGCGGC	0.687000													50	38					0	0	0.000781405	0	0
BLZF1	8548	broad.mit.edu	37	1	169347625	169347625	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:169347625C>T	ENST00000367808.3	+	4	949	c.526C>T	c.(526-528)Cac>Tac	p.H176Y	BLZF1_ENST00000329281.2_Missense_Mutation_p.H176Y			Q9H2G9	GO45_HUMAN	basic leucine zipper nuclear factor 1	176					cell proliferation|Golgi organization|Golgi to plasma membrane protein transport|regulation of cell growth|regulation of transcription from RNA polymerase II promoter	Golgi lumen|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	14	all_hematologic(923;0.208)					TCTTCAGTATCACTTTGAACG	0.388000													49	60					0	0	0.000781405	0	0
RAD50	10111	broad.mit.edu	37	5	131931281	131931281	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr5:131931281C>T	ENST00000378823.3	+	13	2387	c.1569C>T	c.(1567-1569)gcC>gcT	p.A523A	RAD50_ENST00000265335.6_Silent_p.A662A	NM_005732.3	NP_005723.2	Q92878	RAD50_HUMAN	RAD50 homolog (S. cerevisiae)	662					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGGCTGGAGCCACAGCAGTTT	0.373000								Homologous recombination					13	17					0	0	0.000219431	0	0
TTN	7273	broad.mit.edu	37	2	179605631	179605631	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr2:179605631C>T	ENST00000589042.1	-	48	12553	c.12329G>A	c.(12328-12330)gGa>gAa	p.G4110E	TTN_ENST00000342175.6_Missense_Mutation_p.G3939E|TTN_ENST00000591111.1_Missense_Mutation_p.G3793E|TTN_ENST00000460472.2_Missense_Mutation_p.G3747E|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G3872E|TTN-AS1_ENST00000582847.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3793							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCCTGAGCTCCCAAAGGAAG	0.418000													59	83					0	0	0.000781405	0	0
ZNF705B	100132396	broad.mit.edu	37	8	7806707	7806707	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr8:7806707G>A	ENST00000443676.1	+	3	185	c.69G>A	c.(67-69)atG>atA	p.M23I	ZNF705B_ENST00000400120.3_Missense_Mutation_p.M23I			P0CI00	Z705L_HUMAN	zinc finger protein 705B	23	KRAB.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			kidney(2)|lung(2)	4						AGTGGGACATGATGGACACAT	0.418000													58	176					0	0	0.000781405	0	0
DDX53	168400	broad.mit.edu	37	X	23018475	23018475	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chrX:23018475A>T	ENST00000327968.5	+	1	389	c.301A>T	c.(301-303)Atg>Ttg	p.M101L	RP11-40F8.2_ENST00000455399.1_RNA	NM_182699.3	NP_874358.2	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	101	KH.					nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(5)|kidney(4)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	35						CAATAGGGAAATGAAAGCAAA	0.368000													37	26					0	0	0.000953801	0	0
OR52E2	119678	broad.mit.edu	37	11	5080590	5080590	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr11:5080590T>C	ENST00000321522.2	-	1	267	c.268A>G	c.(268-270)Aac>Gac	p.N90D		NM_001005164.2	NP_001005164.2	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E, member 2	90					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(13)|ovary(2)|skin(3)	20		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		CCTCTGAGGTTGATCCAGAAG	0.488000													8	14					0	0	0.000274275	0	0
OR10A3	26496	broad.mit.edu	37	11	7960726	7960726	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr11:7960726G>A	ENST00000360759.3	-	1	415	c.342C>T	c.(340-342)ctC>ctT	p.L114L		NM_001003745.1	NP_001003745.1	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A, member 3	114					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)	21				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TCGCTCCCAGGAGAAAACATT	0.408000													9	22					0	0	0.000442599	0	0
KRT9	3857	broad.mit.edu	37	17	39723595	39723595	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr17:39723595C>T	ENST00000246662.4	-	7	1867	c.1802G>A	c.(1801-1803)gGa>gAa	p.G601E	KRT9_ENST00000588431.1_Missense_Mutation_p.G368E	NM_000226.3	NP_000217.2	P35527	K1C9_HUMAN	keratin 9	601	Tail.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		Breast(137;0.000307)				ttcaccgcctccgtagctgcc	0.562000													5	29					0	0	0.000602214	0	0
ZNF282	8427	broad.mit.edu	37	7	148895701	148895701	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:148895701G>A	ENST00000262085.3	+	2	547	c.442G>A	c.(442-444)Gag>Aag	p.E148K	ZNF282_ENST00000479907.1_Missense_Mutation_p.E148K	NM_003575.2	NP_003566.1	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	148					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	17	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		GAACCACATGGAGAGCAAGTG	0.627000													52	44					0	0	0.000781405	0	0
TLE4	7091	broad.mit.edu	37	9	82267552	82267552	+	Silent	SNP	C	C	T	rs3186577		TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr9:82267552C>T	ENST00000376520.4	+	7	1263	c.435C>T	c.(433-435)ccC>ccT	p.P145P	TLE4_ENST00000376534.4_5'UTR|TLE4_ENST00000265284.6_Silent_p.P120P|TLE4_ENST00000376544.3_Silent_p.P145P|TLE4_ENST00000376537.4_Silent_p.P145P|TLE4_ENST00000455913.1_3'UTR|TLE4_ENST00000376552.2_Silent_p.P145P			O60756	BCE1_HUMAN	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0								p.P145P(2)		breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						ATGGTCTCCCCGTACCTCTGA	0.557000													33	70					0	0	0.000814825	0	0
ABCB5	340273	broad.mit.edu	37	7	20725337	20725337	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:20725337G>A	ENST00000404938.2	+	16	2540	c.1888G>A	c.(1888-1890)Gaa>Aaa	p.E630K	ABCB5_ENST00000258738.6_Missense_Mutation_p.E185K	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	185	ABC transporter 2.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						AAAAGCTGATGAACAGATGGA	0.348000													23	32					0	0	0.00047179	0	0
MED17	9440	broad.mit.edu	37	11	93523911	93523911	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr11:93523911C>T	ENST00000251871.3	+	3	876	c.589C>T	c.(589-591)Cga>Tga	p.R197*		NM_004268.4	NP_004259.3	Q9NVC6	MED17_HUMAN	mediator complex subunit 17	197					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(2)|lung(11)|ovary(1)	14		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CTGGAAACTTCGAAAAGTTGG	0.398000													24	44					0	0	0.000147802	0	0
ZNF277	11179	broad.mit.edu	37	7	111846826	111846826	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:111846826G>A	ENST00000421043.1	+	1	75	c.55G>A	c.(55-57)Ggg>Agg	p.G19R	ZNF277_ENST00000450657.1_Missense_Mutation_p.G19R|ZNF277_ENST00000361822.3_Missense_Mutation_p.G19R			Q9NRM2	ZN277_HUMAN	zinc finger protein 277	19						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	15						AGACCGTGATGGGAGCTGCAG	0.632000													11	45					0	0	0.000308642	0	0
NEB	4703	broad.mit.edu	37	2	152490354	152490354	+	Silent	SNP	T	T	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr2:152490354T>C	ENST00000427231.2	-	65	9430	c.9228A>G	c.(9226-9228)aaA>aaG	p.K3076K	NEB_ENST00000409198.1_Intron|NEB_ENST00000397345.3_Silent_p.K3076K|NEB_ENST00000172853.10_Intron|NEB_ENST00000604864.1_Silent_p.K3076K|NEB_ENST00000603639.1_Silent_p.K3076K	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	3076					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CAAAGTCCTTTTTGTACTCCC	0.527000													76	189					0	0	0.000781405	0	0
LATS2	26524	broad.mit.edu	37	13	21565530	21565530	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr13:21565530C>T	ENST00000382592.4	-	3	761	c.356G>A	c.(355-357)cGa>cAa	p.R119Q	LATS2_ENST00000472754.1_5'UTR|LATS2_ENST00000542899.1_Missense_Mutation_p.R119Q	NM_014572.2	NP_055387.2	Q9NRM7	LATS2_HUMAN	large tumor suppressor kinase 2	119	UBA.				cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(2)	45		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		CTTGAGAGCTCGGCCAGCCAT	0.572000													9	31					0	0	0.000442599	0	0
HECW1	23072	broad.mit.edu	37	7	43477638	43477638	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:43477638G>A	ENST00000395891.1	+	9	1443	c.838G>A	c.(838-840)Gaa>Aaa	p.E280K	HECW1_ENST00000453890.1_Missense_Mutation_p.E280K|HECW1_ENST00000471043.1_3'UTR	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	280	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						TGACGTGCTGGAAATTGAGGT	0.498000													72	80					0	0	0.000781405	0	0
TRIM10	10107	broad.mit.edu	37	6	30128351	30128351	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr6:30128351C>T	ENST00000449742.2	-	1	360	c.285G>A	c.(283-285)gaG>gaA	p.E95E	TRIM10_ENST00000376704.3_Silent_p.E95E	NM_006778.3	NP_006769.2	Q9UDY6	TRI10_HUMAN	tripartite motif containing 10	95						cytoplasm	zinc ion binding			ovary(1)	1						AGACATCCTCCTCTCCCAAAC	0.587000													22	154					0	0	0.000295444	0	0
ASB10	136371	broad.mit.edu	37	7	150873287	150873287	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:150873287C>T	ENST00000422024.1	-	5	1576	c.1451G>A	c.(1450-1452)gGc>gAc	p.G484D	ASB10_ENST00000377867.3_Missense_Mutation_p.G424D|ASB10_ENST00000275838.1_Missense_Mutation_p.G401D|ASB10_ENST00000434669.1_Missense_Mutation_p.G446D|ASB10_ENST00000420175.2_Missense_Mutation_p.G439D	NM_001142459.1	NP_001135931.2	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box containing 10	439					intracellular signal transduction					NS(1)|endometrium(2)|lung(7)|skin(2)	12			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGGCAGGCTGCCCTCCAGGTG	0.667000													28	18					0	0	0.000279167	0	0
BTNL8	79908	broad.mit.edu	37	5	180374511	180374511	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr5:180374511G>A	ENST00000231229.4	+	4	907		c.e4-1		BTNL8_ENST00000400707.3_Splice_Site|BTNL8_ENST00000508408.1_Splice_Site|BTNL8_ENST00000533815.2_Splice_Site|BTNL8_ENST00000340184.4_Splice_Site|BTNL8_ENST00000511704.1_Splice_Site|BTNL8_ENST00000505126.1_Splice_Site	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8							integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTGTTTTTCAGATACCTTTTT	0.393000													26	168					0	0	0.000147802	0	0
IGSF22	283284	broad.mit.edu	37	11	18738353	18738353	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr11:18738353C>T	ENST00000513874.1	-	10	1307	c.1168G>A	c.(1168-1170)Gat>Aat	p.D390N	RP11-1081L13.4_ENST00000527285.1_RNA	NM_173588.3	NP_775859.3	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	390										NS(2)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(20)|ovary(4)|prostate(4)|skin(3)	56						AGTCTGGCATCCTTAATCTTA	0.527000													50	78					0	0	0.000781405	0	0
NDUFAF5	79133	broad.mit.edu	37	20	13782284	13782284	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr20:13782284C>T	ENST00000378106.5	+	7	791	c.672C>T	c.(670-672)gaC>gaT	p.D224D	NDUFAF5_ENST00000463598.1_Silent_p.D196D|NDUFAF5_ENST00000475968.1_3'UTR	NM_024120.4	NP_077025.2	Q5TEU4	CT007_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 5	224					mitochondrial respiratory chain complex I assembly	extrinsic to mitochondrial inner membrane	methyltransferase activity										CTGTCAATGACCTGGGACATC	0.433000													30	85					0	0	0.000692331	0	0
TRAV13-1	28671	broad.mit.edu	37	14	22337313	22337313	+	RNA	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr14:22337313G>A	ENST00000390436.2	+	0	127																											GTCCAGGAGGGAGACAGCGCT	0.438000													21	43					0	0	0.000132079	0	0
MAP7	9053	broad.mit.edu	37	6	136667047	136667047	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr6:136667047C>T	ENST00000354570.3	-	17	2596	c.2186G>A	c.(2185-2187)gGg>gAg	p.G729E	MAP7_ENST00000454590.1_Missense_Mutation_p.G751E|MAP7_ENST00000438100.2_Missense_Mutation_p.G714E|MAP7_ENST00000432797.2_Missense_Mutation_p.G583E|MAP7_ENST00000544465.1_Missense_Mutation_p.G714E	NM_001198616.1|NM_001198617.1|NM_001198619.1|NM_003980.4	NP_001185545.1|NP_001185546.1|NP_001185548.1|NP_003971.1	Q14244	MAP7_HUMAN	microtubule-associated protein 7	729					establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(11)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		CCCAAGTGTCCCTTCATCATC	0.458000													10	13					0	0	6.40141e-05	0	0
KCNQ3	3786	broad.mit.edu	37	8	133152391	133152391	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr8:133152391C>T	ENST00000388996.4	-	11	1920	c.1500G>A	c.(1498-1500)agG>agA	p.R500R	KCNQ3_ENST00000521134.1_Silent_p.R380R|KCNQ3_ENST00000519445.1_Silent_p.R500R	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	500					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TCCCATAGCCCCTGTCTTCCG	0.617000													12	22					0	0	6.40141e-05	0	0
CLDN25	644672	broad.mit.edu	37	11	113650669	113650669	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr11:113650669G>T	ENST00000453129.2	+	1	201	c.152G>T	c.(151-153)tGg>tTg	p.W51L		NM_001101389.1	NP_001094859.1	C9JDP6	CLD25_HUMAN	claudin 25	51						integral to membrane|tight junction	structural molecule activity			large_intestine(1)|lung(6)|ovary(1)|urinary_tract(2)	10						ATGGGGATTTGGGAGGTCTGC	0.562000													10	68					2.17888e-05	0.000266314	0.000442599	1	0
CDH17	1015	broad.mit.edu	37	8	95183181	95183181	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr8:95183181G>A	ENST00000027335.3	-	8	940	c.816C>T	c.(814-816)tcC>tcT	p.S272S	CDH17_ENST00000450165.2_Silent_p.S272S|CDH17_ENST00000441892.2_Intron	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	272	Cadherin 3.					integral to membrane	calcium ion binding			NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			TGTCAACTAAGGAATATTGTG	0.453000													36	47					0	0	0.000692331	0	0
PTPRU	10076	broad.mit.edu	37	1	29587201	29587201	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:29587201C>T	ENST00000356870.3	+	7	1040	c.930C>T	c.(928-930)tcC>tcT	p.S310S	PTPRU_ENST00000345512.3_Silent_p.S310S|PTPRU_ENST00000323874.8_Silent_p.S310S|PTPRU_ENST00000460170.2_Silent_p.S310S|PTPRU_ENST00000428026.2_Silent_p.S310S|PTPRU_ENST00000373779.3_Silent_p.S310S	NM_133177.3	NP_573438.3	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	310	Fibronectin type-III 1.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		ACACCAACTCCATCATTGGCG	0.657000													6	33					0	0	3.59834e-05	0	0
ANKRD12	23253	broad.mit.edu	37	18	9255436	9255436	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr18:9255436C>T	ENST00000383440.2	+	8	2359	c.2102C>T	c.(2101-2103)tCa>tTa	p.S701L	ANKRD12_ENST00000262126.3_Missense_Mutation_p.S724L|ANKRD12_ENST00000400020.3_Missense_Mutation_p.S701L	NM_001083625.2	NP_001077094.1	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12	724						nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						GAAAAAAAATCAAAATTGGAA	0.274000													9	40					0	0	0.000274275	0	0
ARG1	383	broad.mit.edu	37	6	131904954	131904954	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr6:131904954C>T	ENST00000368087.3	+	8	1014	c.875C>T	c.(874-876)aCa>aTa	p.T292I	ARG1_ENST00000476845.1_Missense_Mutation_p.T206I|ARG1_ENST00000356962.2_Missense_Mutation_p.T300I|MED23_ENST00000354577.4_Intron			P05089	ARGI1_HUMAN	arginase 1	292					arginine catabolic process|urea cycle	cytosol	arginase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(1)|skin(3)	14	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0106)|OV - Ovarian serous cystadenocarcinoma(155;0.0713)	L-Ornithine(DB00129)	GTAACTCGAACAGTGAACACA	0.428000													7	23					0	0	8.12818e-05	0	0
C7orf26	79034	broad.mit.edu	37	7	6639599	6639599	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:6639599C>T	ENST00000344417.5	+	4	987	c.720C>T	c.(718-720)ctC>ctT	p.L240L	C7orf26_ENST00000472693.1_3'UTR|C7orf26_ENST00000359073.5_Intron	NM_024067.2	NP_076972.2	Q96N11	CG026_HUMAN	chromosome 7 open reading frame 26	240										endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	11		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)		TCACCCCGCTCGTTGGATTGA	0.483000													9	79					0	0	0.000274275	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887606	12887606	+	Missense_Mutation	SNP	C	C	G	rs58074988		TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:12887606C>G	ENST00000535591.1	-	3	446	c.251G>C	c.(250-252)tGc>tCc	p.C84S		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	84								p.C84S(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						ATTGAGGAAGCACCCATGGGC	0.483000													7	293					0	0	0.000274275	0	0
MIER3	166968	broad.mit.edu	37	5	56219660	56219660	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr5:56219660C>T	ENST00000381226.3	-	12	1083	c.1067_splice	c.e12-1	p.T356_splice	MIER3_ENST00000381213.3_Splice_Site_p.T350_splice|MIER3_ENST00000381199.3_Splice_Site_p.T351_splice|MIER3_ENST00000409421.1_Splice_Site_p.T288_splice|SETD9_ENST00000541720.1_Intron			Q7Z3K6	MIER3_HUMAN	mesoderm induction early response 1, family member 3	351					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|liver(1)|lung(2)|urinary_tract(1)	19		Lung NSC(810;4.65e-05)|Prostate(74;0.0253)|Breast(144;0.0503)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;1.24e-37)		CCATATAGTCCCTGAAAAACA	0.418000													17	162					0	0	0.000958276	0	0
RGS21	431704	broad.mit.edu	37	1	192335123	192335123	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:192335123G>A	ENST00000417209.2	+	5	502	c.328G>A	c.(328-330)Gag>Aag	p.E110K		NM_001039152.3	NP_001034241.1	Q2M5E4	RGS21_HUMAN	regulator of G-protein signaling 21	110	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			NS(1)|endometrium(3)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	15						ATGCTTTGATGAGGCTCAGAA	0.378000													62	44					0	0	0.000781405	0	0
MYH3	4621	broad.mit.edu	37	17	10537449	10537449	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr17:10537449C>T	ENST00000583535.1	-	32	4494	c.4407G>A	c.(4405-4407)gaG>gaA	p.E1469E	MYH3_ENST00000226209.7_Silent_p.E1469E	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	1469					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						TCAGGGATGCCTCCAGCTCTG	0.507000													32	109					0	0	0.000814825	0	0
IL7R	3575	broad.mit.edu	37	5	35876102	35876102	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr5:35876102C>T	ENST00000303115.3	+	8	1023	c.894C>T	c.(892-894)ttC>ttT	p.F298F	IL7R_ENST00000343305.4_3'UTR	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	298					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			ATGTGAGTTTCAATCCTGAAA	0.418000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						21	20					0	0	0.000295444	0	0
ZNF80	7634	broad.mit.edu	37	3	113955133	113955133	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr3:113955133C>T	ENST00000482457.2	-	1	1292	c.789G>A	c.(787-789)caG>caA	p.Q263Q		NM_007136.3	NP_009067.2	P51504	ZNF80_HUMAN	zinc finger protein 80	263						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|urinary_tract(2)	32		Lung NSC(201;0.0233)|all_neural(597;0.0837)				GGATCTTACTCTGTTGGGCAA	0.413000													17	45					0	0	0.000175454	0	0
SNORD114-3	767579	broad.mit.edu	37	14	101419690	101419690	+	RNA	SNP	C	C	T	rs73350929	by1000genomes	TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr14:101419690C>T	ENST00000364969.1	+	0	5					NR_003195.1																						taaaCATGGACCAATGATGAC	0.483000													12	45					0	0	0.00010058	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43826231	43826231	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr12:43826231G>A	ENST00000389420.3	-	21	2971	c.2972C>T	c.(2971-2973)tCt>tTt	p.S991F	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.S991F|ADAMTS20_ENST00000395541.2_Missense_Mutation_p.S145F	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	991	TSP type-1 4.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CATACAATAAGATTCTCGAGA	0.378000													45	38					0	0	0.000781405	0	0
RP1L1	94137	broad.mit.edu	37	8	10469228	10469228	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr8:10469228C>T	ENST00000382483.3	-	4	2603	c.2380G>A	c.(2380-2382)Gaa>Aaa	p.E794K		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	794					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CTGGCCTCTTCCCCCAGGCTG	0.692000													26	56					0	0	0.000339439	0	0
AGO1	26523	broad.mit.edu	37	1	36384665	36384665	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:36384665C>T	ENST00000373204.4	+	18	2488	c.2275C>T	c.(2275-2277)Cga>Tga	p.R759*	AGO1_ENST00000373206.1_Nonsense_Mutation_p.R684*	NM_012199.2	NP_036331.1			argonaute RISC catalytic component 1																		GGGCACCAGCCGACCATCCCA	0.527000													16	15					0	0	0.000132079	0	0
CHD1	1105	broad.mit.edu	37	5	98230354	98230354	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr5:98230354G>A	ENST00000284049.3	-	12	1896	c.1747C>T	c.(1747-1749)Cgg>Tgg	p.R583W		NM_001270.2	NP_001261.2	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	583	Helicase ATP-binding.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	49		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	AATTTTAACCGTTTGGTCTGA	0.259000													5	8					0	0	8.12818e-05	0	0
OR10A3	26496	broad.mit.edu	37	11	7960727	7960727	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr11:7960727A>C	ENST00000360759.3	-	1	414	c.341T>G	c.(340-342)cTc>cGc	p.L114R		NM_001003745.1	NP_001003745.1	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A, member 3	114					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)	21				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CGCTCCCAGGAGAAAACATTC	0.408000													10	22					0	0	6.40141e-05	0	0
LSR	51599	broad.mit.edu	37	19	35757839	35757839	+	Silent	SNP	A	A	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr19:35757839A>C	ENST00000602122.1	+	7	1684	c.1197A>C	c.(1195-1197)cgA>cgC	p.R399R	LSR_ENST00000354900.3_Silent_p.R400R|LSR_ENST00000361790.3_Silent_p.R419R|LSR_ENST00000427250.1_Silent_p.R263R|LSR_ENST00000347609.4_Silent_p.R361R|LSR_ENST00000360798.3_Silent_p.R351R			Q86X29	LSR_HUMAN	lipolysis stimulated lipoprotein receptor	419					embryo development|liver development	chylomicron|integral to membrane|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle	receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	13	all_lung(56;3.91e-09)|Lung NSC(56;5.64e-09)|Esophageal squamous(110;0.162)		Epithelial(14;1.33e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.29e-18)|all cancers(14;7.11e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			ACCCTTCTCGACCTGGCCCCC	0.612000													5	29					0	0	3.59834e-05	0	0
SLC16A14	151473	broad.mit.edu	37	2	230910937	230910937	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr2:230910937G>A	ENST00000295190.4	-	4	1363	c.905C>T	c.(904-906)tCg>tTg	p.S302L		NM_152527.4	NP_689740.2	Q7RTX9	MOT14_HUMAN	solute carrier family 16, member 14	302						integral to membrane|plasma membrane	symporter activity			NS(1)|cervix(1)|endometrium(7)|large_intestine(7)|lung(3)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		AAAGTAGCCCGAATACCAGTC	0.493000													12	26					0	0	0.00010058	0	0
IL15RA	3601	broad.mit.edu	37	10	6002363	6002363	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr10:6002363C>T	ENST00000525219.2	-	4	736	c.442G>A	c.(442-444)Gaa>Aaa	p.E148K	IL15RA_ENST00000379971.1_Missense_Mutation_p.E86K|IL15RA_ENST00000397250.2_Missense_Mutation_p.E86K|IL15RA_ENST00000397255.3_Missense_Mutation_p.E184K|IL15RA_ENST00000397248.2_Missense_Mutation_p.E148K|IL15RA_ENST00000528354.1_Missense_Mutation_p.E151K|IL15RA_ENST00000534292.1_5'UTR|IL15RA_ENST00000530685.1_Missense_Mutation_p.E151K|IL15RA_ENST00000397251.3_Missense_Mutation_p.E119K|IL15RA_ENST00000379977.3_Missense_Mutation_p.E184K	NM_001243539.1	NP_001230468.1	Q13261	I15RA_HUMAN	interleukin 15 receptor, alpha	184					cell proliferation	cytoplasmic vesicle membrane|endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane|nuclear membrane	cytokine receptor activity			cervix(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	5						GCTGTGAGTTCCCAGTTCTTG	0.572000													21	58					0	0	0.00047179	0	0
SERPINB3	6317	broad.mit.edu	37	18	61322970	61322970	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr18:61322970C>T	ENST00000283752.5	-	8	1237	c.1094G>A	c.(1093-1095)tGt>tAt	p.C365Y	SERPINB3_ENST00000332821.8_Missense_Mutation_p.C313Y|SERPINB11_ENST00000489748.1_RNA	NM_006919.2	NP_008850.1	P29508	SPB3_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 3	365					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	36						AGGGTGATTACAATGGAACTC	0.463000													27	86					0	0	0.000586117	0	0
OR7C1	26664	broad.mit.edu	37	19	14910268	14910268	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr19:14910268C>T	ENST00000248073.2	-	1	755	c.681G>A	c.(679-681)agG>agA	p.R227R	OR7A5_ENST00000601611.1_Intron	NM_198944.1	NP_945182.1	O76099	OR7C1_HUMAN	olfactory receptor, family 7, subfamily C, member 1	227					sensory perception of smell|spermatogenesis	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(2)|ovary(2)|prostate(1)	18						CTGAGGAAATCCTCAGTATAG	0.438000													30	35					0	0	0.000184323	0	0
ZNF90	7643	broad.mit.edu	37	19	20215083	20215083	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr19:20215083C>T	ENST00000418063.2	+	2	151	c.39C>T	c.(37-39)ttC>ttT	p.F13F	ZNF90_ENST00000474284.1_Intron	NM_007138.1	NP_009069.1	Q03938	ZNF90_HUMAN	zinc finger protein 90	13	KRAB.					Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|lung(2)|ovary(1)|skin(1)	5						CCATAGAATTCTCTCTGGAGG	0.423000													31	54					0	0	0.000491102	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14848844	14848844	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr18:14848844A>T	ENST00000358984.4	+	34	3134	c.2954A>T	c.(2953-2955)cAa>cTa	p.Q985L		NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1070										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						TGTGTACTACAAAAGGAACTG	0.358000													6	20					0	0	0.000442599	0	0
SORCS2	57537	broad.mit.edu	37	4	7719824	7719824	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr4:7719824C>T	ENST00000507866.2	+	18	2447	c.2338C>T	c.(2338-2340)Ccc>Tcc	p.P780S	SORCS2_ENST00000329016.9_Missense_Mutation_p.P608S	NM_020777.2	NP_065828.2	Q96PQ0	SORC2_HUMAN	sortilin-related VPS10 domain containing receptor 2	780						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(8)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	42						CCTCACGCCGCCCCGGGGCCT	0.647000													8	21					0	0	0.000274275	0	0
SPNS3	201305	broad.mit.edu	37	17	4356364	4356364	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr17:4356364G>A	ENST00000355530.2	+	8	1257	c.977G>A	c.(976-978)gGg>gAg	p.G326E	SPNS3_ENST00000333476.2_Missense_Mutation_p.G199E|SPNS3_ENST00000576069.1_3'UTR	NM_182538.4	NP_872344.3	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3 (Drosophila)	326					lipid transport|transmembrane transport	integral to membrane				NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(6)|stomach(2)	28						GTCATCTTGGGGGCAGAAGCT	0.592000													48	67					0	0	0.000781405	0	0
TTN	7273	broad.mit.edu	37	2	179495667	179495667	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr2:179495667C>A	ENST00000589042.1	-	238	44242	c.44018G>T	c.(44017-44019)cGg>cTg	p.R14673L	TTN_ENST00000342175.6_Missense_Mutation_p.R5800L|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R13032L|TTN_ENST00000460472.2_Missense_Mutation_p.R5608L|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R12105L|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R5733L|TTN-AS1_ENST00000589487.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	13032	Ig-like 96.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTAATTTCCCGATCTAGAAA	0.473000													13	42					5.50884e-06	6.75222e-05	0.00010058	1	0
RNF38	152006	broad.mit.edu	37	9	36357773	36357773	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr9:36357773G>A	ENST00000357058.3	-	5	1094	c.489_splice	c.e5+1	p.P163_splice	RNF38_ENST00000377885.2_Splice_Site_p.P163_splice|RNF38_ENST00000350199.4_Splice_Site_p.P163_splice|RNF38_ENST00000353739.4_Splice_Site_p.P196_splice|RNF38_ENST00000377877.4_Splice_Site_p.P170_splice|RNF38_ENST00000491349.1_5'UTR|RNF38_ENST00000259605.6_Splice_Site_p.P246_splice	NM_194328.2	NP_919309.1	Q9H0F5	RNF38_HUMAN	ring finger protein 38	246							zinc ion binding			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|liver(1)|lung(3)|stomach(1)	11			STAD - Stomach adenocarcinoma(86;0.228)			GAGACTTACTGGAGGAGGCAC	0.483000													6	21					0	0	8.12818e-05	0	0
WDR53	348793	broad.mit.edu	37	3	196288262	196288262	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr3:196288262C>T	ENST00000332629.5	-	3	652	c.85G>A	c.(85-87)Gag>Aag	p.E29K	WDR53_ENST00000429115.1_Intron|WDR53_ENST00000433160.1_Intron	NM_182627.1	NP_872433.1	Q7Z5U6	WDR53_HUMAN	WD repeat domain 53	29										breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	13	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.6e-23)|all cancers(36;1.54e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.29e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		TCTCCGCCCTCTGCTCCAGAA	0.542000													10	8					0	0	0.000673444	0	0
CNKSR1	10256	broad.mit.edu	37	1	26510755	26510755	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:26510755C>T	ENST00000531191.1	+	10	1210	c.203C>T	c.(202-204)cCc>cTc	p.P68L	CNKSR1_ENST00000361530.6_Missense_Mutation_p.P326L|CNKSR1_ENST00000374253.5_Missense_Mutation_p.P333L			Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras 1	333	SAM.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	28		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		AACCCCAGTCCCGGACCCAGC	0.627000													20	92					0	0	0.000295444	0	0
NOL4	8715	broad.mit.edu	37	18	31523130	31523130	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr18:31523130G>A	ENST00000261592.5	-	9	1738	c.1441C>T	c.(1441-1443)Cct>Tct	p.P481S	NOL4_ENST00000538587.1_Missense_Mutation_p.P407S|NOL4_ENST00000589544.1_Intron|NOL4_ENST00000535384.1_Missense_Mutation_p.P196S|NOL4_ENST00000535475.1_Missense_Mutation_p.P262S|NOL4_ENST00000269185.4_Intron	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	481						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						AGGTGGGAAGGAATAGGTCGA	0.413000													17	45					0	0	0.00074312	0	0
GPRC6A	222545	broad.mit.edu	37	6	117113438	117113438	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr6:117113438G>T	ENST00000310357.3	-	6	2669	c.2648C>A	c.(2647-2649)cCc>cAc	p.P883H	GPRC6A_ENST00000530250.1_Missense_Mutation_p.P708H|GPRC6A_ENST00000368549.3_Missense_Mutation_p.P812H	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	883					response to amino acid stimulus		G-protein coupled receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		ACTAGAGCTGGGATTGGTCAT	0.468000													14	70					4.3838e-07	5.41918e-06	0.000151284	1	0
ARMC5	79798	broad.mit.edu	37	16	31471181	31471181	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr16:31471181C>T	ENST00000457010.2	+	1	1037	c.336C>T	c.(334-336)tcC>tcT	p.S112S	ARMC5_ENST00000563544.1_Silent_p.S112S|ARMC5_ENST00000538189.1_Silent_p.S144S|ARMC5_ENST00000408912.3_Silent_p.S207S|ARMC5_ENST00000268314.4_Silent_p.S112S	NM_024742.2	NP_079018.1	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5	112							binding			central_nervous_system(1)|endometrium(4)|large_intestine(3)|liver(2)|lung(12)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						ccgcccccTCCGCTGTGTCGT	0.741000													6	5					0	0	3.59834e-05	0	0
SH3TC1	54436	broad.mit.edu	37	4	8221096	8221096	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr4:8221096G>T	ENST00000539824.1	+	9	1097	c.723G>T	c.(721-723)caG>caT	p.Q241H	SH3TC1_ENST00000245105.3_Missense_Mutation_p.Q317H			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	317							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						CAGACTTCCAGGGCTCGGGGC	0.672000													12	130					1.15088e-07	1.43085e-06	0.000422831	1	0
CHST8	64377	broad.mit.edu	37	19	34263477	34263477	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr19:34263477G>A	ENST00000262622.3	+	4	1542	c.784G>A	c.(784-786)Gag>Aag	p.E262K	CHST8_ENST00000438847.2_Missense_Mutation_p.E262K|CHST8_ENST00000434302.1_Missense_Mutation_p.E262K	NM_022467.3	NP_071912.2	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	262					carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(5)	27	Esophageal squamous(110;0.162)					CGAGCCCTTCGAGAGGCTGGT	0.617000													38	42					0	0	0.000437636	0	0
SLC6A3	6531	broad.mit.edu	37	5	1441562	1441562	+	Silent	SNP	C	C	T	rs112801202		TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr5:1441562C>T	ENST00000270349.9	-	3	457	c.330G>A	c.(328-330)ggG>ggA	p.G110G	SLC6A3_ENST00000453492.2_Silent_p.G110G	NM_001044.4	NP_001035.1	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 3	110					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(19)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	AAAGTGGCATCCCAGCAATGA	0.577000													4	31					0	0	0.000602214	0	0
PCDHB4	56131	broad.mit.edu	37	5	140502118	140502118	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr5:140502118C>T	ENST00000194152.1	+	1	538	c.538C>T	c.(538-540)Ctc>Ttc	p.L180F		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		180	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTTTCACATTCTCACTCGAAA	0.473000													12	17					0	0	6.40141e-05	0	0
OR10J3	441911	broad.mit.edu	37	1	159283708	159283708	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:159283708C>T	ENST00000332217.5	-	1	741	c.742G>A	c.(742-744)Gtg>Atg	p.V248M		NM_001004467.1	NP_001004467.1	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J, member 3	248					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(19)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	47	all_hematologic(112;0.0429)					ATGATGACCACTGTGAGGTGG	0.517000													17	62					0	0	0.00074312	0	0
CXXC11	285093	broad.mit.edu	37	2	242814328	242814328	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr2:242814328C>T	ENST00000343216.3	+	2	649	c.621C>T	c.(619-621)tcC>tcT	p.S207S		NM_173821.2	NP_776182.2	Q14D33	CB085_HUMAN	CXXC finger protein 11	207						integral to membrane											TCCCCTTCTCCCTTGTGGGTA	0.682000													8	27					0	0	0.000673444	0	0
WNT3A	89780	broad.mit.edu	37	1	228238595	228238595	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:228238595C>T	ENST00000284523.1	+	3	630	c.552C>T	c.(550-552)aaC>aaT	p.N184N	WNT3A_ENST00000366753.2_Silent_p.N184N	NM_033131.3	NP_149122.1	P56704	WNT3A_HUMAN	wingless-type MMTV integration site family, member 3A	184					axis specification|cell proliferation in forebrain|cell-cell signaling|cellular response to retinoic acid|convergent extension|dermatome development|dorsal/ventral neural tube patterning|embryonic pattern specification|extracellular matrix organization|hemopoietic stem cell proliferation|hippocampus development|inner ear morphogenesis|mammary gland development|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of neuron projection development|notochord development|palate development|paraxial mesodermal cell fate commitment|positive regulation of catenin import into nucleus|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter|signalosome assembly|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled-2 binding|receptor agonist activity|signal transducer activity|transcription coactivator activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)	12		Prostate(94;0.0405)				CAGCCATGAACCGCCACAACA	0.647000													11	18					0	0	0.000673444	0	0
DNAH11	8701	broad.mit.edu	37	7	21781669	21781669	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:21781669C>T	ENST00000328843.6	+	50	8091	c.8060C>T	c.(8059-8061)cCc>cTc	p.P2687L	DNAH11_ENST00000409508.3_Missense_Mutation_p.P2680L			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2687	AAA 3 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						AGGAGTGGCCCCACTTTGATC	0.393000									Kartagener syndrome				22	201					0	0	0.000295444	0	0
USH2A	7399	broad.mit.edu	37	1	216465577	216465577	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:216465577G>A	ENST00000366943.2	-	10	2166	c.1780C>T	c.(1780-1782)Cct>Tct	p.P594S	USH2A_ENST00000307340.3_Missense_Mutation_p.P594S|USH2A_ENST00000366942.3_Missense_Mutation_p.P594S			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	594	Laminin EGF-like 2.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGCTCAAAAGGAAATGGGTCT	0.433000										HNSCC(13;0.011)			5	95					0	0	8.12818e-05	0	0
TBC1D9	23158	broad.mit.edu	37	4	141598154	141598154	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr4:141598154G>A	ENST00000442267.2	-	6	1027	c.953C>T	c.(952-954)cCa>cTa	p.P318L		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	318	GRAM 2.					intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				TTTGTTAAATGGAGTCCAGAG	0.453000													60	84					0	0	0.000781405	0	0
NID1	4811	broad.mit.edu	37	1	236143949	236143949	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:236143949G>A	ENST00000264187.6	-	17	3314	c.3232C>T	c.(3232-3234)Ctt>Ttt	p.L1078F	NID1_ENST00000366595.3_Missense_Mutation_p.L945F	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	1078					cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GTCCAGTAAAGGTTCCTGGAG	0.438000													25	29					0	0	0.000227799	0	0
RNF126	55658	broad.mit.edu	37	19	651671	651671	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr19:651671C>T	ENST00000292363.5	-	4	538	c.383G>A	c.(382-384)cGc>cAc	p.R128H		NM_194460.2	NP_919442.1	Q9BV68	RN126_HUMAN	ring finger protein 126	128							protein binding|zinc ion binding			lung(1)	1		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGGCGGGCGCGGGGCTGTCG	0.781000													6	5					0	0	3.59834e-05	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65810581	65810581	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr11:65810581C>T	ENST00000312006.4	-	3	974	c.693G>A	c.(691-693)gtG>gtA	p.V231V	GAL3ST3_ENST00000527878.1_Silent_p.V231V	NM_033036.2	NP_149025.1	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	231					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			kidney(1)|lung(9)|ovary(2)|skin(2)	14						AAACCTCCTCCACCTGGCGGA	0.662000													11	55					0	0	0.000219431	0	0
SLC27A6	28965	broad.mit.edu	37	5	128302185	128302185	+	Missense_Mutation	SNP	G	G	A	rs142676290	byFrequency	TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr5:128302185G>A	ENST00000262462.4	+	1	1365	c.355G>A	c.(355-357)Gtt>Att	p.V119I	SLC27A6_ENST00000506176.1_Missense_Mutation_p.V119I|SLC27A6_ENST00000395266.1_Missense_Mutation_p.V119I			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	119					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		GCCGGACTTCGTTCACGTGTG	0.572000													12	12					0	0	0.000219431	0	0
ZNF142	7701	broad.mit.edu	37	2	219507131	219507131	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr2:219507131C>T	ENST00000411696.2	-	7	4887	c.4108G>A	c.(4108-4110)Gat>Aat	p.D1370N	ZNF142_ENST00000449707.1_Missense_Mutation_p.D1370N			P52746	ZN142_HUMAN	zinc finger protein 142	1370					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(7)|endometrium(7)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		CGGTGCTCATCCAGAGCCAGT	0.637000													21	37					0	0	0.000295444	0	0
CMTR1	23070	broad.mit.edu	37	6	37411865	37411865	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr6:37411865C>T	ENST00000373451.4	+	3	388	c.224C>T	c.(223-225)tCt>tTt	p.S75F		NM_015050.2	NP_055865.1	Q8N1G2	MTR1_HUMAN		75					mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(6)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(2)	31						AAAGCAGACTCTCTTGTGGAA	0.468000													353	80					0	0	0.000781405	0	0
NKX2-2	4821	broad.mit.edu	37	20	21493043	21493043	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr20:21493043T>C	ENST00000377142.4	-	2	696	c.340A>G	c.(340-342)Aat>Gat	p.N114D		NM_002509.3	NP_002500.1	O95096	NKX22_HUMAN	NK2 homeobox 2	114					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21						TCCTTGTCATTGTCCGGTGAC	0.697000													13	19					0	0	0.000151284	0	0
RBM11	54033	broad.mit.edu	37	21	15599222	15599222	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr21:15599222G>A	ENST00000400577.3	+	5	463	c.454G>A	c.(454-456)Gtg>Atg	p.V152M	RBM11_ENST00000468643.1_3'UTR	NM_144770.3	NP_658983.3	P57052	RBM11_HUMAN	RNA binding motif protein 11	152							nucleotide binding|RNA binding			endometrium(3)|kidney(3)|lung(7)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	16				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		GTATAATCCAGTGCTGCAGCT	0.393000													37	98					0	0	0.000319135	0	0
PTBP3	9991	broad.mit.edu	37	9	115013260	115013260	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr9:115013260G>A	ENST00000334318.6	-	8	1030	c.844C>T	c.(844-846)Cct>Tct	p.P282S	PTBP3_ENST00000374255.2_Missense_Mutation_p.P279S|PTBP3_ENST00000458258.1_Missense_Mutation_p.P285S|PTBP3_ENST00000374257.1_Missense_Mutation_p.P251S|PTBP3_ENST00000343327.2_Missense_Mutation_p.P184S	NM_001163790.2|NM_005156.6	NP_001157262.1|NP_005147.3	O95758	ROD1_HUMAN	polypyrimidine tract binding protein 3	279					anatomical structure morphogenesis|mRNA processing	nucleus	nucleotide binding|RNA binding										TCACCAGTAGGAAGGTCTAAG	0.448000													10	117					0	0	0.000442599	0	0
TM9SF2	9375	broad.mit.edu	37	13	100204470	100204470	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr13:100204470G>C	ENST00000376387.4	+	13	1568	c.1378G>C	c.(1378-1380)Gga>Cga	p.G460R		NM_004800.1	NP_004791.1	Q99805	TM9S2_HUMAN	transmembrane 9 superfamily member 2	460					transport	endosome membrane|integral to plasma membrane				endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(2)	17	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.218)					CTGGGGAGAAGGATCTTCAGC	0.418000													25	68					0	0	0.000720815	0	0
PTCD2	79810	broad.mit.edu	37	5	71622533	71622533	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr5:71622533G>A	ENST00000380639.5	+	3	331	c.315G>A	c.(313-315)cgG>cgA	p.R105R	PTCD2_ENST00000536805.1_5'UTR|PTCD2_ENST00000503868.1_Intron|PTCD2_ENST00000543322.1_Silent_p.R105R	NM_024754.3	NP_079030.3	Q8WV60	PTCD2_HUMAN	pentatricopeptide repeat domain 2	105										breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(6)|lung(1)|skin(1)	11		Lung NSC(167;0.00237)|Ovarian(174;0.0175)|Prostate(461;0.141)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.73e-53)		GTGAGTCTCGGGACCATGTGG	0.413000													44	54					0	0	0.000781405	0	0
IQCH	64799	broad.mit.edu	37	15	67664977	67664977	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr15:67664977G>A	ENST00000335894.4	+	9	1348	c.1282G>A	c.(1282-1284)Gag>Aag	p.E428K	IQCH_ENST00000360277.4_Missense_Mutation_p.E180K|IQCH_ENST00000546225.1_Missense_Mutation_p.E176K|IQCH_ENST00000358767.3_Missense_Mutation_p.E255K	NM_001031715.2	NP_001026885.1	Q86VS3	IQCH_HUMAN	IQ motif containing H	428										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		GAGACACCTGGAGAATTTTCG	0.453000													19	92					0	0	0.000295444	0	0
FBXL5	26234	broad.mit.edu	37	4	15627133	15627133	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr4:15627133C>A	ENST00000341285.3	-	9	1716	c.1592G>T	c.(1591-1593)aGt>aTt	p.S531I	FBXL5_ENST00000412094.2_Missense_Mutation_p.S514I|FBXL5_ENST00000382358.4_Missense_Mutation_p.S405I	NM_001193534.1|NM_001193535.1|NM_012161.3	NP_001180463.1|NP_001180464.1|NP_036293.1	Q9UKA1	FBXL5_HUMAN	F-box and leucine-rich repeat protein 5	531					iron ion homeostasis|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|SCF ubiquitin ligase complex	iron ion binding|protein binding|ubiquitin-protein ligase activity			endometrium(2)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	13						CCAACAGACACTAGTCCTTAG	0.413000													20	29					2.4624e-09	3.09691e-08	0.000132079	1	0
ASXL1	171023	broad.mit.edu	37	20	31024546	31024546	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr20:31024546C>T	ENST00000375687.4	+	13	4455	c.4031C>T	c.(4030-4032)tCc>tTc	p.S1344F	ASXL1_ENST00000306058.5_Missense_Mutation_p.S1339F	NM_015338.5	NP_056153.2	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 (Drosophila)	1344					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(655)|kidney(5)|large_intestine(18)|liver(1)|lung(27)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	722						AGCACAAACTCCATGTCTGGT	0.572000			"""F, N, Mis"""		"""MDS, CMML"""								12	68					0	0	0.000151284	0	0
IGSF21	84966	broad.mit.edu	37	1	18691797	18691797	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:18691797G>A	ENST00000251296.1	+	6	1004	c.621G>A	c.(619-621)caG>caA	p.Q207Q		NM_032880.4	NP_116269.3	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21	207						extracellular region				endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	40		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		GCCCCCTACAGGACAGCAGGC	0.607000													16	39					0	0	0.00074312	0	0
KMT2D	8085	broad.mit.edu	37	12	49420526	49420526	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr12:49420526C>T	ENST00000301067.7	-	48	15222	c.15223G>A	c.(15223-15225)Ggg>Agg	p.G5075R		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D									p.G5075R(1)|p.G4805R(1)									ATCAGTGCCCCGCCCTGGGTC	0.627000													16	9					0	0	0.000422831	0	0
CCDC158	339965	broad.mit.edu	37	4	77300459	77300459	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr4:77300459C>T	ENST00000388914.3	-	8	1165	c.1013G>A	c.(1012-1014)aGg>aAg	p.R338K	CCDC158_ENST00000434846.2_Missense_Mutation_p.R338K	NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	338										breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						TTCATACATCCTTTTGGCTTC	0.353000													53	67					0	0	0.000781405	0	0
MC3R	4159	broad.mit.edu	37	20	54824661	54824661	+	Silent	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr20:54824661C>T	ENST00000243911.2	+	1	874	c.762C>T	c.(760-762)tgC>tgT	p.C254C		NM_019888.3	NP_063941.3	P41968	MC3R_HUMAN	melanocortin 3 receptor	291					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(3)|skin(1)	26			Colorectal(105;0.202)			TCATCTTCTGCTGGGCCCCCT	0.597000													31	38					0	0	0.000227799	0	0
C1orf168	199920	broad.mit.edu	37	1	57185941	57185941	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:57185941C>T	ENST00000343433.6	-	18	2116	c.2036G>A	c.(2035-2037)gGa>gAa	p.G679E		NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	679								p.G679V(1)		NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						ATCAAATATTCCATTTCTTGA	0.348000													22	63					0	0	0.00047179	0	0
STMN2	11075	broad.mit.edu	37	8	80553695	80553695	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr8:80553695A>T	ENST00000220876.7	+	3	580	c.198A>T	c.(196-198)gaA>gaT	p.E66D	STMN2_ENST00000518111.1_Missense_Mutation_p.E66D|STMN2_ENST00000518491.1_Missense_Mutation_p.E55D	NM_001199214.1|NM_007029.3	NP_001186143.1|NP_008960.2	Q93045	STMN2_HUMAN	stathmin-like 2	66	Regulatory/phosphorylation domain (Potential).				intracellular signal transduction|negative regulation of microtubule depolymerization|negative regulation of microtubule polymerization|negative regulation of neuron projection development|neuron differentiation|positive regulation of microtubule depolymerization|positive regulation of neuron projection development	axon|growth cone|membrane|membrane fraction|perinuclear region of cytoplasm|soluble fraction	protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	11	all_lung(9;8.34e-05)		Epithelial(68;0.0229)|all cancers(69;0.0874)			CTATCTCAGAAGCCCCACGAA	0.453000													20	48					0	0	0.000175454	0	0
OR10J3	441911	broad.mit.edu	37	1	159283707	159283707	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:159283707A>T	ENST00000332217.5	-	1	742	c.743T>A	c.(742-744)gTg>gAg	p.V248E		NM_001004467.1	NP_001004467.1	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J, member 3	248					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(19)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	47	all_hematologic(112;0.0429)					GATGATGACCACTGTGAGGTG	0.512000													17	62					0	0	0.00074312	0	0
TBCK	93627	broad.mit.edu	37	4	107157662	107157662	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr4:107157662G>A	ENST00000273980.4	-	15	1682	c.1235C>T	c.(1234-1236)cCt>cTt	p.P412L	TBCK_ENST00000394708.2_Missense_Mutation_p.P412L|TBCK_ENST00000432496.2_Missense_Mutation_p.P412L|TBCK_ENST00000361687.4_Missense_Mutation_p.P349L|TBCK_ENST00000394706.3_Missense_Mutation_p.P373L			Q8TEA7	TBCK_HUMAN	TBC1 domain containing kinase	412						intracellular	Rab GTPase activator activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	25						GTTTGAATGAGGTAAATTAGA	0.338000													36	39					0	0	0.000814825	0	0
KYNU	8942	broad.mit.edu	37	2	143713800	143713800	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr2:143713800G>A	ENST00000264170.4	+	6	722	c.464G>A	c.(463-465)cGa>cAa	p.R155Q	KYNU_ENST00000375773.2_Missense_Mutation_p.R155Q|KYNU_ENST00000409512.1_Missense_Mutation_p.R155Q	NM_003937.2	NP_003928.1	Q16719	KYNU_HUMAN	kynureninase	155					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			large_intestine(10)|liver(1)|lung(18)|prostate(3)|skin(4)	36				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	ACGCCAAAACGATATAAAATT	0.308000													16	66					0	0	0.000422831	0	0
KCNJ6	3763	broad.mit.edu	37	21	39087253	39087253	+	Silent	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr21:39087253G>A	ENST00000400482.3	-	3	796	c.207C>T	c.(205-207)aaC>aaT	p.N69N	KCNJ6_ENST00000288309.6_Silent_p.N69N	NM_002240.3	NP_002231.1	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 6	69					synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22					Halothane(DB01159)	TCTCCCTCACGTTGCCGTGAT	0.478000													33	67					0	0	0.000814825	0	0
PKD1L1	168507	broad.mit.edu	37	7	47968864	47968864	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:47968864C>T	ENST00000289672.2	-	7	1047	c.997G>A	c.(997-999)Gaa>Aaa	p.E333K		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	333					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						AGCCTCATTTCAACCCCAGAA	0.522000													98	112					0	0	0.000781405	0	0
PLS3	5358	broad.mit.edu	37	X	114863527	114863527	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chrX:114863527A>C	ENST00000420625.2	+	4	389	c.255A>C	c.(253-255)aaA>aaC	p.K85N	PLS3_ENST00000289290.3_Missense_Mutation_p.K40N|PLS3_ENST00000539310.1_Missense_Mutation_p.K40N|PLS3_ENST00000537301.1_Missense_Mutation_p.K63N|PLS3_ENST00000355899.3_Missense_Mutation_p.K85N	NM_001136025.3|NM_001172335.1	NP_001129497.1|NP_001165806.1	P13797	PLST_HUMAN	plastin 3	85	EF-hand 2.					cytoplasm	actin binding|calcium ion binding			NS(2)|breast(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(11)	26						AAGAGGTAAAAAGTAGTGATA	0.333000													9	8					0	0	0.000274275	0	0
PRAMEF12	390999	broad.mit.edu	37	1	12835087	12835087	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr1:12835087C>A	ENST00000357726.4	+	1	104	c.77C>A	c.(76-78)cCc>cAc	p.P26H		NM_001080830.1	NP_001074299.1	O95522	PRA12_HUMAN	PRAME family member 12	26										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(9)|ovary(3)|skin(1)|urinary_tract(1)	23	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTGGCCATCCCCACCCTGGAG	0.592000													37	26					6.53348e-20	8.24092e-19	0.000692331	1	0
GRIN3A	116443	broad.mit.edu	37	9	104432571	104432571	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr9:104432571C>T	ENST00000361820.3	-	3	2723	c.2123G>A	c.(2122-2124)cGa>cAa	p.R708Q		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	708					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	ACTTCTATTTCGCCCCTTGGG	0.463000													11	109					0	0	0.000151284	0	0
KIAA1033	23325	broad.mit.edu	37	12	105550525	105550525	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr12:105550525G>A	ENST00000332180.5	+	27	2867	c.2780G>A	c.(2779-2781)cGa>cAa	p.R927Q		NM_015275.1	NP_056090.1	Q2M389	WAHS7_HUMAN	KIAA1033	927					endosome transport	WASH complex				breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	41						GGCTATGTACGAATGATAAGA	0.313000													15	91					0	0	0.000132079	0	0
KRT84	3890	broad.mit.edu	37	12	52775309	52775309	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr12:52775309C>T	ENST00000257951.3	-	5	979	c.912_splice	c.e5-1	p.E305_splice	RP3-416H24.4_ENST00000547174.1_RNA	NM_033045.3	NP_149034.2	Q9NSB2	KRT84_HUMAN	keratin 84	305	Coil 1B.|Rod.					keratin filament	structural constituent of epidermis			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(10)|skin(3)	27	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		AACTGGATTTCCTGTGTTGGA	0.542000													61	86					0	0	0.000781405	0	0
CHD1	1105	broad.mit.edu	37	5	98230355	98230355	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr5:98230355T>A	ENST00000284049.3	-	12	1895	c.1746A>T	c.(1744-1746)aaA>aaT	p.K582N		NM_001270.2	NP_001261.2	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	582	Helicase ATP-binding.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	49		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	ATTTTAACCGTTTGGTCTGAT	0.259000													5	8					0	0	8.12818e-05	0	0
UGT2B10	7365	broad.mit.edu	37	4	69681886	69681886	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr4:69681886A>C	ENST00000265403.7	+	1	176	c.149A>C	c.(148-150)cAt>cCt	p.H50P	UGT2B10_ENST00000458688.2_Missense_Mutation_p.H50P	NM_001075.4	NP_001066.1	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B10	50					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						CAGAGAGGTCATGAGGTGACT	0.418000													92	117					0	0	0.000781405	0	0
ANKRD36BP2	645784	broad.mit.edu	37	2	89083945	89083946	+	RNA	INS	-	-	GC			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr2:89083945_89083946insGC	ENST00000393525.3	+	0	576																											GTATTCCTTTTTTTTCAGTGTA	0.347													3	4	---	---	---	---					
QRICH1	54870	broad.mit.edu	37	3	49114419	49114426	+	Frame_Shift_Del	DEL	AAGGAGAT	AAGGAGAT	-			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr3:49114419_49114426delAAGGAGAT	ENST00000395443.2	-	2	497_504	c.25_32delATCTCCTT	c.(25-33)tfs	p.ISF9fs	QRICH1_ENST00000357496.2_Frame_Shift_Del_p.ISF9fs|QRICH1_ENST00000424300.1_Frame_Shift_Del_p.ISF9fs	NM_198880.1	NP_942581.1	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	9	CARD.									breast(2)|endometrium(5)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		GTACTCTTCAAAGGAGATGGTGTTCTCT	0.452													10	103	---	---	---	---					
KMT2E	55904	broad.mit.edu	37	7	104715133	104715133	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr7:104715133delG	ENST00000334877.4	+	8	1134	c.600delG	c.(598-600)gtfs	p.V200fs	KMT2E_ENST00000257745.4_Frame_Shift_Del_p.V200fs|KMT2E_ENST00000476671.1_Frame_Shift_Del_p.V200fs|KMT2E_ENST00000334914.7_5'UTR|KMT2E_ENST00000311117.3_Frame_Shift_Del_p.V200fs					lysine (K)-specific methyltransferase 2E																		AGGTTCCTGTGGAATTATATA	0.328													44	171	---	---	---	---					
CLEC4A	50856	broad.mit.edu	37	12	8281937	8281937	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr12:8281937delA	ENST00000229332.5	+	3	524	c.277delA	c.(277-279)aafs	p.K94fs	CLEC4A_ENST00000352620.3_Intron|CLEC4A_ENST00000345999.3_Intron|CLEC4A_ENST00000360500.3_Frame_Shift_Del_p.K55fs	NM_016184.3|NM_194447.2|NM_194450.2	NP_057268.1|NP_919429.2|NP_919432.1	Q9UMR7	CLC4A_HUMAN	C-type lectin domain family 4, member A	94					cell adhesion|cell surface receptor linked signaling pathway|innate immune response	integral to plasma membrane	sugar binding|transmembrane receptor activity			cervix(1)|endometrium(3)|large_intestine(2)|lung(4)|prostate(1)	11				Kidney(36;0.0915)		GGAGTGTGTGAAAAAAAATAT	0.333													8	218	---	---	---	---					
TRAV24	28659	broad.mit.edu	37	14	22573825	22573826	+	RNA	INS	-	-	A	rs33991650	by1000genomes	TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr14:22573825_22573826insA	ENST00000390453.1	+	0	55																											GACTCTTTTTTAAAAAAACAGG	0.450													7	7	---	---	---	---					
ROCK1P1	727758	broad.mit.edu	37	18	112402	112405	+	RNA	DEL	AACC	AACC	-	rs113232824		TCGA-FS-A1ZM-06A-12D-A197-08	TCGA-FS-A1ZM-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d1db56b-5464-45e7-8bca-0cb4655fbfc4	1245a11a-f1d1-448a-a29a-7a2d6e6efacb	g.chr18:112402_112405delAACC	ENST00000576266.1	+	0	36_39																											CCCTGCCCCGAACCACCCGACCCC	0.711													3	3	---	---	---	---