Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GHR	2690	broad.mit.edu	37	5	42718721	42718721	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr5:42718721A>C	ENST00000230882.4	+	10	1302	c.1112A>C	c.(1111-1113)gAg>gCg	p.E371A	GHR_ENST00000513625.1_3'UTR|GHR_ENST00000357703.3_Missense_Mutation_p.E349A|GHR_ENST00000537449.1_Missense_Mutation_p.E184A	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor	371					2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	AGTGACCATGAGAAATCACAT	0.433000													36	6					0	0	7.24521e-05	0	0
CXXC1	30827	broad.mit.edu	37	18	47812187	47812187	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr18:47812187T>A	ENST00000285106.6	-	5	1285	c.571A>T	c.(571-573)Aag>Tag	p.K191*	CXXC1_ENST00000412036.2_Nonsense_Mutation_p.K191*|CXXC1_ENST00000589940.1_Nonsense_Mutation_p.K191*	NM_001101654.1|NM_014593.3	NP_001095124.1|NP_055408.2	Q9P0U4	CXXC1_HUMAN	CXXC finger protein 1	191					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			autonomic_ganglia(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	24						CCGAACTTCTTCATGTCCCGA	0.622000													15	18					0	0	5.01169e-05	0	0
HCFC1	3054	broad.mit.edu	37	X	153227717	153227717	+	Silent	SNP	C	C	T			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chrX:153227717C>T	ENST00000310441.7	-	5	1719	c.753G>A	c.(751-753)gcG>gcA	p.A251A	HCFC1_ENST00000354233.3_Silent_p.A251A|HCFC1_ENST00000461098.1_5'UTR|HCFC1_ENST00000369984.4_Silent_p.A251A	NM_005334.2	NP_005325.2	P51610	HCFC1_HUMAN	host cell factor C1 (VP16-accessory protein)	251					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GAGGAAGAGGCGCCACCCCGC	0.597000													8	9					0	0	3.86212e-05	0	0
ATRN	8455	broad.mit.edu	37	20	3515900	3515900	+	Splice_Site	SNP	A	A	G			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr20:3515900A>G	ENST00000262919.5	+	2	479	c.410_splice	c.e2-1	p.R137_splice	ATRN_ENST00000446916.2_Splice_Site_p.R137_splice	NM_139321.2	NP_647537.1	O75882	ATRN_HUMAN	attractin	137	CUB.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			breast(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	59						TAAATTACAGACTAACTGGAT	0.279000													21	35					0	0	0.000229342	0	0
VPS54	51542	broad.mit.edu	37	2	64160813	64160813	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr2:64160813T>G	ENST00000354504.3	-	9	1863	c.1274A>C	c.(1273-1275)gAt>gCt	p.D425A	VPS54_ENST00000272322.4_Missense_Mutation_p.D578A|VPS54_ENST00000409558.3_Missense_Mutation_p.D566A			Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 homolog (S. cerevisiae)	578					protein transport|retrograde transport, endosome to Golgi					endometrium(3)|kidney(4)|large_intestine(8)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	27						TCACATAATATCCACACCTCC	0.388000													13	21					0	0	5.01169e-05	0	0
TNC	3371	broad.mit.edu	37	9	117808817	117808817	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr9:117808817A>C	ENST00000350763.4	-	17	5408	c.4997T>G	c.(4996-4998)aTa>aGa	p.I1666R	TNC_ENST00000423613.2_Intron|TNC_ENST00000345230.3_Intron|TNC_ENST00000346706.3_Missense_Mutation_p.I1120R|TNC_ENST00000341037.4_Missense_Mutation_p.I1484R|TNC_ENST00000542877.1_Missense_Mutation_p.I1303R|TNC_ENST00000340094.3_Missense_Mutation_p.I1302R|TNC_ENST00000537320.1_Intron|TNC_ENST00000535648.1_Missense_Mutation_p.I1211R	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	1666	Fibronectin type-III 12.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						AAGTAGGGTTATTTCCAGTGG	0.473000													4	58					0	0	0.00024832	0	0
PIGU	128869	broad.mit.edu	37	20	33176297	33176297	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr20:33176297G>C	ENST00000374820.2	-	7	702	c.682C>G	c.(682-684)Ctc>Gtc	p.L228V	PIGU_ENST00000452740.2_Missense_Mutation_p.L248V|PIGU_ENST00000480175.1_5'UTR			Q9H490	PIGU_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class U	248					attachment of GPI anchor to protein|C-terminal protein lipidation|regulation of JAK-STAT cascade	GPI-anchor transamidase complex|plasma membrane				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	9						CAAGAGCTGAGAAGGAAGAAG	0.433000													10	15					0	0	6.40141e-05	0	0
STK38	11329	broad.mit.edu	37	6	36467713	36467713	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr6:36467713T>C	ENST00000229812.7	-	10	1174	c.889A>G	c.(889-891)Acc>Gcc	p.T297A		NM_007271.2	NP_009202.1	Q15208	STK38_HUMAN	serine/threonine kinase 38	297	Protein kinase.				intracellular protein kinase cascade|negative regulation of MAP kinase activity	cytoplasm|MLL5-L complex	ATP binding|magnesium ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity			NS(1)|endometrium(4)|large_intestine(2)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TTGTACCCGGTCTGCATGAAC	0.522000													7	62					0	0	8.12818e-05	0	0
HIST1H2BI	8346	broad.mit.edu	37	6	26273355	26273355	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr6:26273355C>G	ENST00000377733.2	+	1	212	c.152C>G	c.(151-153)cCc>cGc	p.P51R		NM_003525.2	NP_003516.1	P62807	H2B1C_HUMAN	histone cluster 1, H2bi	51					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			central_nervous_system(1)|cervix(2)|endometrium(3)|large_intestine(1)|lung(8)|urinary_tract(1)	16						CAGGTCCACCCCGACACCGGC	0.572000													5	167					0	0	8.12818e-05	0	0
MBD5	55777	broad.mit.edu	37	2	149247828	149247828	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr2:149247828C>T	ENST00000407073.1	+	12	4925	c.3928C>T	c.(3928-3930)Caa>Taa	p.Q1310*	MBD5_ENST00000404807.1_Nonsense_Mutation_p.Q1543*	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1310						chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		CACTGCAAAGCAAGACCTGGT	0.443000													21	25					0	0	0.000229342	0	0
NLRP10	338322	broad.mit.edu	37	11	7982724	7982724	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr11:7982724C>A	ENST00000328600.2	-	2	596	c.435G>T	c.(433-435)caG>caT	p.Q145H		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	145							ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		ACTCCAGCTCCTGCTCCGGGA	0.592000													16	18					2.31682e-05	0.00150298	0.000308642	1	0
IQGAP2	10788	broad.mit.edu	37	5	75970327	75970327	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr5:75970327G>C	ENST00000274364.6	+	27	3617	c.3320G>C	c.(3319-3321)cGg>cCg	p.R1107P	IQGAP2_ENST00000396234.3_Missense_Mutation_p.R603P|IQGAP2_ENST00000502745.1_Missense_Mutation_p.R603P|IQGAP2_ENST00000379730.3_Missense_Mutation_p.R609P	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	1107	Ras-GAP.				small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		CTGTACTATCGGTACATGAAT	0.388000													4	41					0	0	8.12818e-05	0	0
FKBP9	11328	broad.mit.edu	37	7	33042361	33042361	+	Silent	SNP	G	G	A			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr7:33042361G>A	ENST00000242209.4	+	9	1615	c.1446G>A	c.(1444-1446)gaG>gaA	p.E482E	FKBP9_ENST00000538443.1_Silent_p.E344E|AVL9_ENST00000404479.1_Intron|FKBP9_ENST00000538336.1_Silent_p.E535E|FKBP9_ENST00000490776.2_Silent_p.E250E	NM_007270.3	NP_009201.2	O95302	FKBP9_HUMAN	FK506 binding protein 9, 63 kDa	482					protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	39			GBM - Glioblastoma multiforme(11;0.0156)			GCCTTCCTGAGGGGTACATGT	0.532000													16	3					0	0	3.45872e-05	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	T	rs121913529		TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr12:25398284C>T	ENST00000311936.3	-	2	226	c.35G>A	c.(34-36)gGt>gAt	p.G12D	KRAS_ENST00000256078.4_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000556131.1_Missense_Mutation_p.G12D	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			17	2					0	0	0.000295444	0	0
TBC1D8B	54885	broad.mit.edu	37	X	106109035	106109035	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chrX:106109035T>G	ENST00000357242.5	+	16	2608	c.2434T>G	c.(2434-2436)Tta>Gta	p.L812V	TBC1D8B_ENST00000276175.3_Missense_Mutation_p.L806V	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	812						intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						AGAGCTGTTTTTATCTTGTTA	0.328000													47	67					0	0	0.000125731	0	0
HYI	81888	broad.mit.edu	37	1	43917105	43917105	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr1:43917105C>A	ENST00000583037.1	-	7	931	c.517G>T	c.(517-519)Gtg>Ttg	p.V173L	HYI_ENST00000372426.1_Missense_Mutation_p.V198L|SZT2_ENST00000562955.1_3'UTR|HYI_ENST00000372432.1_Missense_Mutation_p.V246L|HYI_ENST00000372434.1_Missense_Mutation_p.V271L|SZT2_ENST00000372442.1_3'UTR|HYI_ENST00000486909.1_Missense_Mutation_p.V246L|HYI_ENST00000372425.4_Missense_Mutation_p.V246L	NM_001190880.2	NP_001177809.1	Q5T013	HYI_HUMAN	hydroxypyruvate isomerase (putative)	246							hydroxypyruvate isomerase activity			large_intestine(1)|lung(2)|ovary(1)|urinary_tract(2)	6	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TCACAGCCCACGAAGCCTTTG	0.622000													17	21					9.16793e-09	6.07674e-07	5.01169e-05	1	0
PCDHB14	56122	broad.mit.edu	37	5	140604055	140604055	+	Silent	SNP	T	T	C			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr5:140604055T>C	ENST00000239449.4	+	1	978	c.978T>C	c.(976-978)ggT>ggC	p.G326G	PCDHB14_ENST00000515856.2_Silent_p.G173G	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		326	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATGGTGGGGGTCTTTCAGGAA	0.383000													6	47					0	0	3.59834e-05	0	0
LMOD1	25802	broad.mit.edu	37	1	201868801	201868801	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr1:201868801A>C	ENST00000367288.4	-	2	1586	c.1340T>G	c.(1339-1341)cTg>cGg	p.L447R	RP11-307B6.3_ENST00000458139.1_RNA|RP11-307B6.3_ENST00000414927.1_RNA	NM_012134.2	NP_036266.2	P29536	LMOD1_HUMAN	leiomodin 1 (smooth muscle)	447					muscle contraction	cytoskeleton|cytosol|membrane fraction	tropomyosin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						CAGCTTGAGCAGGGTAGTATT	0.567000													5	6					0	0	3.59834e-05	0	0
GLP1R	2740	broad.mit.edu	37	6	39041404	39041404	+	Silent	SNP	C	C	T			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr6:39041404C>T	ENST00000373256.4	+	7	725	c.682C>T	c.(682-684)Ctg>Ttg	p.L228L		NM_002062.3	NP_002053.3	P43220	GLP1R_HUMAN	glucagon-like peptide 1 receptor	228					activation of adenylate cyclase activity|cAMP-mediated signaling|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	glucagon receptor activity|peptide receptor activity, G-protein coupled			breast(5)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	31					Exenatide(DB01276)|Glucagon recombinant(DB00040)	GAGCTGCCGCCTGGTGTTTCT	0.587000													26	34					0	0	0.000147802	0	0
SLC22A12	116085	broad.mit.edu	37	11	64366364	64366364	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr11:64366364C>A	ENST00000377574.1	+	6	1786	c.1039C>A	c.(1039-1041)Cgc>Agc	p.R347S	SLC22A12_ENST00000473690.1_Missense_Mutation_p.R126S|SLC22A12_ENST00000377572.1_Missense_Mutation_p.R239S|SLC22A12_ENST00000336464.7_Missense_Mutation_p.R313S|SLC22A12_ENST00000377567.2_Missense_Mutation_p.R239S	NM_144585.2	NP_653186.2	Q96S37	S22AC_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 12	347					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27						GCCCGGACTGCGCTTCCGGAC	0.667000													10	12					6.40141e-05	0.00398325	6.40141e-05	1	0
ADCY2	108	broad.mit.edu	37	5	7789862	7789862	+	Silent	SNP	G	G	A			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr5:7789862G>A	ENST00000338316.4	+	20	2666	c.2577G>A	c.(2575-2577)gtG>gtA	p.V859V	ADCY2_ENST00000537121.1_Silent_p.V679V	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	859					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						TGGAGAACGTGCTTCCCGCGC	0.562000													11	62					0	0	3.86212e-05	0	0
SSTR3	6753	broad.mit.edu	37	22	37602855	37602855	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr22:37602855G>A	ENST00000328544.3	-	2	1521	c.988C>T	c.(988-990)Cgg>Tgg	p.R330W	SSTR3_ENST00000402501.1_Missense_Mutation_p.R330W	NM_001051.3	NP_001042.1	P32745	SSR3_HUMAN	somatostatin receptor 3	330					G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)	14						CGGGAGGGCCGCAGCAGGACC	0.662000													10	2					0	0	0.000151284	0	0
FER1L6	654463	broad.mit.edu	37	8	125035704	125035704	+	Silent	SNP	C	C	T			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr8:125035704C>T	ENST00000522917.1	+	18	2360	c.2154C>T	c.(2152-2154)gaC>gaT	p.D718D	FER1L6-AS1_ENST00000518567.1_RNA|FER1L6_ENST00000399018.1_Silent_p.D718D	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	718						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CTATCCCTGACGTTTTCATCT	0.527000													18	31					0	0	0.000295444	0	0
TMEM86B	255043	broad.mit.edu	37	19	55739565	55739565	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr19:55739565C>T	ENST00000327042.4	-	2	814	c.292G>A	c.(292-294)Gtc>Atc	p.V98I	AC010327.2_ENST00000598855.1_3'UTR	NM_173804.4	NP_776165.3	Q8N661	TM86B_HUMAN	transmembrane protein 86B	98					ether lipid metabolic process	cytoplasmic part|integral to membrane	alkenylglycerophosphocholine hydrolase activity|alkenylglycerophosphoethanolamine hydrolase activity			skin(2)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0443)		TCACCAGGGACGAAGGCTGCC	0.652000													8	8					0	0	2.17888e-05	0	0
MBTD1	54799	broad.mit.edu	37	17	49270312	49270312	+	Silent	SNP	A	A	G			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr17:49270312A>G	ENST00000586178.1	-	15	1864	c.1521T>C	c.(1519-1521)cgT>cgC	p.R507R	MBTD1_ENST00000376381.2_3'UTR|MBTD1_ENST00000415868.1_Silent_p.R507R	NM_017643.2	NP_060113.2	Q05BQ5	MBTD1_HUMAN	mbt domain containing 1	507					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|skin(1)|urinary_tract(1)	12			BRCA - Breast invasive adenocarcinoma(22;1.54e-08)			CACATATTAAACGTGGCTCCA	0.388000													48	67					0	0	0.000147903	0	0
UBIAD1	29914	broad.mit.edu	37	1	11333715	11333715	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr1:11333715A>G	ENST00000376810.5	+	1	453	c.127A>G	c.(127-129)Agg>Ggg	p.R43G	UBIAD1_ENST00000376804.2_Missense_Mutation_p.R43G	NM_013319.2	NP_037451.1	Q9Y5Z9	UBIA1_HUMAN	UbiA prenyltransferase domain containing 1	43					menaquinone biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrion|nucleus	prenyltransferase activity			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(3)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.012)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.52e-06)|COAD - Colon adenocarcinoma(227;0.000254)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0487)		GCGCTCCTGGAGGCAGAAGTG	0.622000													8	13					0	0	0.000157383	0	0
KCNB1	3745	broad.mit.edu	37	20	47990456	47990456	+	Silent	SNP	G	G	T			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr20:47990456G>T	ENST00000371741.4	-	2	1807	c.1641C>A	c.(1639-1641)acC>acA	p.T547T		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	547					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CTGACTCCTTGGTATTGAGGA	0.517000													7	160					0.000157383	0.00959723	0.000157383	1	0
PDHX	8050	broad.mit.edu	37	11	34991758	34991758	+	Missense_Mutation	SNP	A	A	C	rs146262415		TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr11:34991758A>C	ENST00000448838.3	+	7	1086	c.844A>C	c.(844-846)Act>Cct	p.T282P	PDHX_ENST00000227868.4_Missense_Mutation_p.T297P|PDHX_ENST00000430469.2_Intron	NM_001135024.1|NM_003477.2	NP_001128496.1|NP_003468.2	O00330	ODPX_HUMAN	pyruvate dehydrogenase complex, component X	297					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	acyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)	16	all_epithelial(35;0.115)|Lung NSC(22;0.218)|all_lung(20;0.242)	all_hematologic(20;0.124)	STAD - Stomach adenocarcinoma(6;0.00113)			ATCTAAAAGTACTGTACCTCA	0.393000													13	24					0	0	0.000219431	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140750027	140750027	+	Silent	SNP	C	C	G			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr5:140750027C>G	ENST00000576222.1	+	1	197	c.66C>G	c.(64-66)ctC>ctG	p.L22L	PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTTCCTGCTCTCTTTGTTAG	0.587000													4	22					0	0	0.00024832	0	0
MC1R	4157	broad.mit.edu	37	16	89985811	89985811	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr16:89985811G>C	ENST00000555427.1	+	3	2448	c.145G>C	c.(145-147)Ggg>Cgg	p.G49R	TUBB3_ENST00000556922.1_Missense_Mutation_p.G49R|MC1R_ENST00000555147.1_Missense_Mutation_p.G49R					melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	11		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		CCTCAGCCTGGGGCTGGTGAG	0.647000									Melanoma, Familial Clustering of				3	18					0	0	6.4e-05	0	0
GPX7	2882	broad.mit.edu	37	1	53072382	53072382	+	Silent	SNP	C	C	T			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr1:53072382C>T	ENST00000361314.4	+	2	203	c.165C>T	c.(163-165)agC>agT	p.S55S	GPX7_ENST00000459779.1_3'UTR	NM_015696.4	NP_056511.2	Q96SL4	GPX7_HUMAN	glutathione peroxidase 7	55					response to oxidative stress	extracellular region	glutathione peroxidase activity			breast(1)|kidney(1)|lung(4)|upper_aerodigestive_tract(1)	7					Glutathione(DB00143)	ATGTGGCCAGCGAGTGCGGCT	0.572000													11	8					0	0	6.40141e-05	0	0
GRIPAP1	56850	broad.mit.edu	37	X	48847416	48847416	+	Silent	SNP	C	C	T			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chrX:48847416C>T	ENST00000376423.4	-	6	437	c.405G>A	c.(403-405)ccG>ccA	p.P135P	GRIPAP1_ENST00000376444.3_Silent_p.P143P|GRIPAP1_ENST00000376425.3_Silent_p.P188P|GRIPAP1_ENST00000376441.1_Silent_p.P188P|GRIPAP1_ENST00000473581.1_5'UTR	NM_207672.1	NP_997555.1	Q4V328	GRAP1_HUMAN	GRIP1 associated protein 1	188						early endosome		p.P135P(2)|p.P188P(1)		breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(2)	10						CCTCTGCCAACGGCATGGGGG	0.597000													14	4					0	0	0.000308642	0	0
CROCCP2	84809	broad.mit.edu	37	1	16952952	16952952	+	RNA	SNP	G	G	A	rs1762946	by1000genomes	TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr1:16952952G>A	ENST00000412962.1	-	0	664																											TCTGCCCTCAGCTTGGTCACG	0.622000													5	18					0	0	1.23904e-05	0	0
PRKDC	5591	broad.mit.edu	37	8	48840367	48840367	+	Silent	SNP	A	A	G			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr8:48840367A>G	ENST00000314191.2	-	20	2279	c.2223T>C	c.(2221-2223)atT>atC	p.I741I	PRKDC_ENST00000338368.3_Silent_p.I741I|PRKDC_ENST00000523565.1_5'UTR	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	741					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CATCGAGTTCAATGATGTTGT	0.443000								Non-homologous end-joining					9	16					0	0	2.17888e-05	0	0
NMRAL1	57407	broad.mit.edu	37	16	4511935	4511935	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr16:4511935A>G	ENST00000574733.1	-	6	1475	c.746T>C	c.(745-747)cTt>cCt	p.L249P	NMRAL1_ENST00000574425.1_Missense_Mutation_p.L249P|NMRAL1_ENST00000283429.6_Missense_Mutation_p.L249P|NMRAL1_ENST00000404295.3_Missense_Mutation_p.L249P			Q9HBL8	NMRL1_HUMAN	NmrA-like family domain containing 1	249						nucleus|perinuclear region of cytoplasm	binding			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|prostate(2)|stomach(1)	15						GGGAAAGCCAAGCTTTTCGTA	0.647000													27	29					0	0	0.000147802	0	0
APC	324	broad.mit.edu	37	5	112173801	112173801	+	Nonsense_Mutation	SNP	C	C	G	rs79512956		TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr5:112173801C>G	ENST00000457016.1	+	16	2890	c.2510C>G	c.(2509-2511)tCa>tGa	p.S837*	CTC-554D6.1_ENST00000520401.1_Intron|APC_ENST00000257430.4_Nonsense_Mutation_p.S837*|APC_ENST00000508376.2_Nonsense_Mutation_p.S837*			P25054	APC_HUMAN	adenomatous polyposis coli	837	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TCCTCTTCATCAAGAGGAAGC	0.398000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			22	22					0	0	0.000229342	0	0
FAM83B	222584	broad.mit.edu	37	6	54805115	54805115	+	Missense_Mutation	SNP	C	C	T	rs147775708	byFrequency	TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr6:54805115C>T	ENST00000306858.7	+	5	1462	c.1346C>T	c.(1345-1347)gCg>gTg	p.A449V		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	449										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					AATCGGCTTGCGCAGAGAAAA	0.463000													12	29					0	0	0.00010058	0	0
CAPNS1	826	broad.mit.edu	37	19	36640548	36640548	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr19:36640548C>G	ENST00000587718.1	+	10	855	c.790C>G	c.(790-792)Ccc>Gcc	p.P264A	CAPNS1_ENST00000246533.3_Intron|CAPNS1_ENST00000589146.1_Intron|CAPNS1_ENST00000588780.1_Intron|CAPNS1_ENST00000590874.1_Intron|CAPNS1_ENST00000588815.1_Intron			P04632	CPNS1_HUMAN	calpain, small subunit 1	0	EF-hand 5.			WLQLTMYS -> VRTPILGYGCLGGPHPSALHTSSELQSPS SYFASRPWVRAKGLVLLGFPVLTLHPPLPSGCS (in Ref. 7; AAH11903).	positive regulation of cell proliferation	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			cervix(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	5	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GGTAAGGACCCCCATATTGGG	0.572000													8	9					0	0	0.000157383	0	0
ST6GALNAC1	55808	broad.mit.edu	37	17	74625601	74625601	+	Silent	SNP	C	C	T			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr17:74625601C>T	ENST00000156626.7	-	2	523	c.324G>A	c.(322-324)ccG>ccA	p.P108P	ST6GALNAC1_ENST00000590878.1_5'UTR	NM_018414.3	NP_060884.1	Q9NSC7	SIA7A_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	108					protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	22						GCTCCTCCGGCGGTGCCTGGT	0.587000													15	16					0	0	0.000219431	0	0
ZBTB1	22890	broad.mit.edu	37	14	64988483	64988483	+	Silent	SNP	T	T	A			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr14:64988483T>A	ENST00000358738.3	+	2	652	c.261T>A	c.(259-261)atT>atA	p.I87I	RP11-973N13.4_ENST00000554918.1_RNA|ZBTB1_ENST00000394712.2_Silent_p.I87I|ZBTB1_ENST00000554015.1_Silent_p.I87I	NM_014950.2	NP_055765.2	Q9Y2K1	ZBTB1_HUMAN	zinc finger and BTB domain containing 1	87	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	13		all_lung(585;0.000567)|Myeloproliferative disorder(585;0.0255)|all_neural(303;0.0294)		UCEC - Uterine corpus endometrioid carcinoma (185;0.0182)|all cancers(60;3.78e-43)|OV - Ovarian serous cystadenocarcinoma(108;1.22e-20)|BRCA - Breast invasive adenocarcinoma(234;6.75e-06)|KIRC - Kidney renal clear cell carcinoma(182;0.00269)|STAD - Stomach adenocarcinoma(64;0.012)		TAGGAAAAATTATGACAGCTC	0.373000													22	43					0	0	0.000229342	0	0
DHX30	22907	broad.mit.edu	37	3	47882497	47882497	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr3:47882497G>A	ENST00000446256.2	+	8	952	c.380G>A	c.(379-381)cGg>cAg	p.R127Q	DHX30_ENST00000348968.4_Missense_Mutation_p.R138Q|DHX30_ENST00000457607.1_Missense_Mutation_p.R194Q|DHX30_ENST00000445061.1_Missense_Mutation_p.R166Q	NM_014966.3	NP_055781.2	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 30	166						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			endometrium(3)|kidney(1)|large_intestine(11)|lung(13)|ovary(4)|pancreas(1)|prostate(1)|skin(3)	37				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		ACTTCCTGGCGGCAGCTGAAT	0.597000													5	8					0	0	1.23904e-05	0	0
DMD	1756	broad.mit.edu	37	X	32486764	32486764	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chrX:32486764C>T	ENST00000357033.4	-	23	3219	c.3013G>A	c.(3013-3015)Gag>Aag	p.E1005K	DMD_ENST00000378677.2_Missense_Mutation_p.E1001K	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1005					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTCGACATCTCTTTCACAGTG	0.403000													22	4					0	0	0.000375601	0	0
CYLC2	1539	broad.mit.edu	37	9	105765476	105765476	+	Silent	SNP	T	T	C			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr9:105765476T>C	ENST00000374798.3	+	3	181	c.111T>C	c.(109-111)ttT>ttC	p.F37F	CYLC2_ENST00000487798.1_Silent_p.F37F	NM_001340.3	NP_001331.1	Q14093	CYLC2_HUMAN	cylicin, basic protein of sperm head cytoskeleton 2	37	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)	41		all_hematologic(171;0.125)				CCCTGTTATTTCCCAAACCAC	0.368000													16	40					0	0	9.7654e-05	0	0
L3MBTL4	91133	broad.mit.edu	37	18	5969390	5969390	+	Splice_Site	SNP	A	A	G			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr18:5969390A>G	ENST00000284898.6	-	18	1842		c.e18+1		L3MBTL4_ENST00000400105.2_Splice_Site|L3MBTL4_ENST00000535782.1_Splice_Site|L3MBTL4_ENST00000317931.7_Splice_Site	NM_173464.3	NP_775735.2	Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)						chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				AGCTCCACTCACCTCATCCAC	0.622000													4	37					0	0	3.59834e-05	0	0
PLA2G2F	64600	broad.mit.edu	37	1	20465966	20465967	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr1:20465966_20465967delGT	ENST00000375102.3	+	1	148_149	c.46_47delGT	c.(46-48)gfs	p.V16fs		NM_022819.3	NP_073730.3	Q9BZM2	PA2GF_HUMAN	phospholipase A2, group IIF	0					lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	15		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000247)|Lung NSC(340;0.000285)|Breast(348;0.000812)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.000524)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		CAAAAAGAAGGTGCTGGATAGA	0.579													2	4	---	---	---	---					
RP11-423O2.5	0	broad.mit.edu	37	1	142803299	142803302	+	RNA	DEL	CAAC	CAAC	-	rs79529551		TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr1:142803299_142803302delCAAC	ENST00000423385.1	-	0	1663_1666																											acaacaacaacaacaaACAGGATG	0.387													3	4	---	---	---	---					
LINC00971	440970	broad.mit.edu	37	3	84740804	84740805	+	RNA	DEL	AG	AG	-			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr3:84740804_84740805delAG	ENST00000484892.1	-	0	2354					NR_033860.1																						tggaaaccccagaaggataaga	0.421													2	4	---	---	---	---					
HECTD1	25831	broad.mit.edu	37	14	31602754	31602755	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr14:31602754_31602755insT	ENST00000399332.1	-	23	4193_4194	c.3705_3706insA	c.(3703-3708)gatttafs	p.DL1235fs	HECTD1_ENST00000553700.1_Frame_Shift_Ins_p.DL1235fs	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	1235					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		GTGCCATAAAGTTCGAATCCAG	0.376													45	56	---	---	---	---					
HERC1	8925	broad.mit.edu	37	15	64039192	64039192	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr15:64039192delG	ENST00000443617.2	-	12	2532	c.2445delC	c.(2443-2445)ctfs	p.L815fs		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	815					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						CCTGCCTCCCGAGAATGCTGG	0.478													2	4	---	---	---	---