Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CROCCP2	84809	broad.mit.edu	37	1	16953672	16953672	+	RNA	SNP	C	C	T	rs3738597	by1000genomes	TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:16953672C>T	ENST00000412962.1	-	0	589																											TCGGTCTTCTCGGCCTGCAGC	0.652000													6	49					0	0	0.000157383	0	0
TP53BP2	7159	broad.mit.edu	37	1	223986192	223986192	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:223986192C>T	ENST00000391878.2	-	13	2054	c.1286G>A	c.(1285-1287)aGa>aAa	p.R429K	TP53BP2_ENST00000498843.1_5'UTR|TP53BP2_ENST00000391879.2_Intron|TP53BP2_ENST00000343537.7_Missense_Mutation_p.R558K	NM_005426.2	NP_005417.1	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2	552					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(131;0.0958)		TAGCAGCACTCTCGGCTGCTG	0.542000													80	164					0	0	0.000781405	0	0
MYBPC2	4606	broad.mit.edu	37	19	50958811	50958811	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:50958811G>A	ENST00000357701.5	+	20	2299	c.2248G>A	c.(2248-2250)Gac>Aac	p.D750N		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	750	Fibronectin type-III 2.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		GGATGTGACAGACACCACCAC	0.587000													36	68					0	0	0.00148497	0	0
TCERG1	10915	broad.mit.edu	37	5	145826961	145826961	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr5:145826961G>A	ENST00000296702.5	+	1	87	c.49G>A	c.(49-51)Ggg>Agg	p.G17R	TCERG1_ENST00000394421.2_Missense_Mutation_p.G17R	NM_006706.3	NP_006697.2	O14776	TCRG1_HUMAN	transcription elongation regulator 1	17					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(18)|lung(9)|ovary(2)|prostate(3)|skin(1)	46		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATTCAACCCGGGGGAGCTCAG	0.647000													7	11					0	0	0.000274275	0	0
CHL1	10752	broad.mit.edu	37	3	447292	447292	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr3:447292C>A	ENST00000256509.2	+	28	4215	c.3573C>A	c.(3571-3573)ttC>ttA	p.F1191L	CHL1_ENST00000397491.2_Missense_Mutation_p.F1175L	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	1175					axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		ATGGTCTCTTCAGTGAAGATG	0.478000													31	11					3.90053e-15	1.69536e-14	0.0024448	1	0
NUAK1	9891	broad.mit.edu	37	12	106461156	106461156	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr12:106461156C>T	ENST00000261402.2	-	7	2789	c.1410G>A	c.(1408-1410)aaG>aaA	p.K470K		NM_014840.2	NP_055655.1	O60285	NUAK1_HUMAN	NUAK family, SNF1-like kinase, 1	470							ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	37						TCTGCTGGGTCTTTTTCAAGA	0.572000													25	18					0	0	0.000586117	0	0
GPRIN3	285513	broad.mit.edu	37	4	90169055	90169055	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr4:90169055G>A	ENST00000333209.3	-	2	2725	c.2207C>T	c.(2206-2208)tCc>tTc	p.S736F		NM_198281.2	NP_938022.2	Q6ZVF9	GRIN3_HUMAN	GPRIN family member 3	736										breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|prostate(2)|skin(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		AGTATCTGAGGAAATGGATCT	0.478000													36	61					0	0	0.000953801	0	0
CNDP1	84735	broad.mit.edu	37	18	72245505	72245505	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr18:72245505A>G	ENST00000582365.1	+	8	1047	c.981A>G	c.(979-981)atA>atG	p.I327M	CNDP1_ENST00000358821.3_Missense_Mutation_p.I370M			Q96KN2	CNDP1_HUMAN	carnosine dipeptidase 1 (metallopeptidase M20 family)	370					proteolysis	extracellular region	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity|tripeptidase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27		Esophageal squamous(42;0.129)|Prostate(75;0.157)|Melanoma(33;0.211)		BRCA - Breast invasive adenocarcinoma(31;0.109)		GCCGAGTTATAGGAAAATTTT	0.428000													57	48					0	0	0.000781405	0	0
TNNC2	7125	broad.mit.edu	37	20	44452684	44452684	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr20:44452684C>T	ENST00000372557.1	-	6	559	c.352G>A	c.(352-354)Gaa>Aaa	p.E118K	TNNC2_ENST00000372555.3_Missense_Mutation_p.E133K			P02585	TNNC2_HUMAN	troponin C type 2 (fast)	133	EF-hand 3.				muscle filament sliding|regulation of muscle contraction|skeletal muscle contraction	cytosol|troponin complex	calcium ion binding			endometrium(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	5		Myeloproliferative disorder(115;0.0122)				ATCAGAGATTCGATCTCCTCG	0.612000													57	58					0	0	0.000781405	0	0
DDX1	1653	broad.mit.edu	37	2	15735288	15735288	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:15735288G>A	ENST00000381341.2	+	3	425	c.36G>A	c.(34-36)gaG>gaA	p.E12E	DDX1_ENST00000233084.3_Silent_p.E12E			Q92499	DDX1_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 1	12	Helicase ATP-binding.|Necessary for interaction with HNRNPK.|Necessary for interaction with RELA.				DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(13)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)		TAATGCCTGAGATTGCACAAG	0.318000													20	29					0	0	0.00229938	0	0
DGKZ	8525	broad.mit.edu	37	11	46393075	46393075	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr11:46393075C>T	ENST00000454345.1	+	9	1370	c.1245C>T	c.(1243-1245)atC>atT	p.I415I	DGKZ_ENST00000456247.2_Silent_p.I226I|DGKZ_ENST00000528615.1_Silent_p.I5I|DGKZ_ENST00000527911.1_Silent_p.I227I|DGKZ_ENST00000395574.3_Silent_p.I193I|DGKZ_ENST00000421244.2_Silent_p.I227I|DGKZ_ENST00000543978.1_Intron|DGKZ_ENST00000343674.6_Silent_p.I243I|DGKZ_ENST00000318201.8_Silent_p.I204I|DGKZ_ENST00000532868.2_Silent_p.I231I	NM_001105540.1	NP_001099010.1	Q13574	DGKZ_HUMAN	diacylglycerol kinase, zeta	415					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|pancreas(1)|prostate(1)|skin(1)	25				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		TGCAGCAGATCGAGGAGCCGT	0.677000													14	16					0	0	0.00185496	0	0
REG4	83998	broad.mit.edu	37	1	120342418	120342418	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:120342418G>A	ENST00000354219.1	-	5	672	c.233C>T	c.(232-234)aCc>aTc	p.T78I	REG4_ENST00000530654.1_Missense_Mutation_p.T78I|REG4_ENST00000256585.5_Missense_Mutation_p.T78I	NM_001159352.1	NP_001152824.1	Q9BYZ8	REG4_HUMAN	regenerating islet-derived family, member 4	78	C-type lectin.					extracellular region	sugar binding			central_nervous_system(1)|large_intestine(1)|lung(8)|ovary(2)|prostate(1)|skin(2)	15	all_cancers(5;4.81e-10)|all_epithelial(5;7.98e-11)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;8.1e-07)|Lung NSC(69;5.89e-06)|all_epithelial(167;0.000959)		Lung(183;0.011)|LUSC - Lung squamous cell carcinoma(189;0.0588)		CTCTGCTATGGTGCTGGCTTC	0.512000													120	263					0	0	0.000781405	0	0
FHOD3	80206	broad.mit.edu	37	18	34289066	34289066	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr18:34289066G>T	ENST00000257209.4	+	15	1842	c.1720G>T	c.(1720-1722)Ggg>Tgg	p.G574W	FHOD3_ENST00000359247.4_Missense_Mutation_p.G557W|FHOD3_ENST00000445677.1_Missense_Mutation_p.G536W|FHOD3_ENST00000590592.1_Missense_Mutation_p.G749W|FHOD3_ENST00000587493.1_3'UTR|FHOD3_ENST00000591635.1_Intron	NM_025135.2	NP_079411.2	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	557					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|liver(2)|lung(29)|ovary(3)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	90		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				AGCAAGTGCCGGGGATCCTGA	0.542000													5	128					0.00198382	0.00836347	0.00198382	1	0
CYLC1	1538	broad.mit.edu	37	X	83128980	83128980	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chrX:83128980G>A	ENST00000329312.4	+	4	1301	c.1264G>A	c.(1264-1266)Gaa>Aaa	p.E422K		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	422					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity	p.E421K(1)		NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						TCAGAAAGATGAAAAAAAGGA	0.343000													12	1					0	0	0.00185496	0	0
TMC1	117531	broad.mit.edu	37	9	75403334	75403334	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr9:75403334G>A	ENST00000297784.5	+	14	1504	c.964G>A	c.(964-966)Gac>Aac	p.D322N	TMC1_ENST00000340019.3_Missense_Mutation_p.D322N|TMC1_ENST00000396237.3_Missense_Mutation_p.D322N	NM_138691.2	NP_619636.2	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	322					sensory perception of sound	integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(21)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	36						TACCAGCTGGGACTACCTGAT	0.398000													27	37					0	0	0.00106085	0	0
OAS3	4940	broad.mit.edu	37	12	113398967	113398967	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr12:113398967C>T	ENST00000228928.7	+	8	1928	c.1749C>T	c.(1747-1749)ttC>ttT	p.F583F	RP1-71H24.1_ENST00000552784.1_RNA	NM_006187.2	NP_006178.2	Q9Y6K5	OAS3_HUMAN	2'-5'-oligoadenylate synthetase 3, 100kDa	583	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding	p.F583F(1)		breast(3)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|skin(2)	27						AGGCCTGCTTCGCAGAGCTGC	0.582000													12	16					0	0	0.00185496	0	0
STAT4	6775	broad.mit.edu	37	2	191941042	191941042	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:191941042G>A	ENST00000392320.2	-	4	597	c.283C>T	c.(283-285)Cat>Tat	p.H95Y	STAT4_ENST00000358470.4_Missense_Mutation_p.H95Y	NM_003151.3	NP_003142.1	Q14765	STAT4_HUMAN	signal transducer and activator of transcription 4	95					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(4)|endometrium(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			GGATTTCCATGAAATTTTCCC	0.328000													48	63					0	0	0.000781405	0	0
SULT1E1	6783	broad.mit.edu	37	4	70715154	70715154	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr4:70715154C>T	ENST00000226444.3	-	5	609		c.e5+1			NM_005420.2	NP_005411.1	P49888	ST1E1_HUMAN	sulfotransferase family 1E, estrogen-preferring, member 1						3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol|nuclear membrane	estrone sulfotransferase activity|flavonol 3-sulfotransferase activity|steroid binding|steroid sulfotransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	10						GCTGTTCCTACCCTGTCCTTG	0.378000													21	53					0	0	0.00229938	0	0
OR14K1	343170	broad.mit.edu	37	1	247902192	247902192	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:247902192C>T	ENST00000283225.2	+	1	276	c.276C>T	c.(274-276)ttC>ttT	p.F92F	RP11-634B7.4_ENST00000449298.1_RNA					olfactory receptor, family 14, subfamily K, member 1											NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|lung(18)|ovary(1)|urinary_tract(1)	27						CCATCTCCTTCCTGGGGTGTG	0.517000													33	19					0	0	0.00148497	0	0
XIST	7503	broad.mit.edu	37	X	73071669	73071669	+	RNA	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chrX:73071669C>T	ENST00000429829.1	-	0	919					NR_001564.2																						GGCCACTTTTCCTCCACAATC	0.473000													51	9					0	0	0.000781405	0	0
OR5AC2	81050	broad.mit.edu	37	3	97806585	97806585	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr3:97806585C>T	ENST00000358642.2	+	1	569	c.569C>T	c.(568-570)tCa>tTa	p.S190L		NM_054106.1	NP_473447.1	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC, member 2	190					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|large_intestine(3)|lung(13)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	28						TTCAAAATTTCATGCAATGGT	0.313000													25	59					0	0	0.000720815	0	0
TRIOBP	11078	broad.mit.edu	37	22	38120387	38120387	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr22:38120387C>T	ENST00000406386.3	+	7	2079	c.1824C>T	c.(1822-1824)ccC>ccT	p.P608P	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	608					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					GGGACAATCCCAGAGCCTCCA	0.582000													28	55					0	0	0.001512	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72658179	72658179	+	RNA	SNP	T	T	C	rs147293416	by1000genomes	TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr7:72658179T>C	ENST00000425256.1	-	0	1732					NR_002164.1																						cagagtgatttcggatgaatt	0.507000													3	5					0	0	0.00024832	0	0
TFAP4	7023	broad.mit.edu	37	16	4310169	4310169	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr16:4310169G>A	ENST00000204517.6	-	6	1072	c.744C>T	c.(742-744)atC>atT	p.I248I		NM_003223.2	NP_003214.1	Q01664	TFAP4_HUMAN	transcription factor AP-4 (activating enhancer binding protein 4)	248					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation by host of viral transcription|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|regulation of S phase of mitotic cell cycle	transcriptional repressor complex	E-box binding|histone deacetylase binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|endometrium(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	14						TGACGACATTGATGTGGTGGG	0.627000													43	30					0	0	0.000781405	0	0
PRR12	57479	broad.mit.edu	37	19	50099247	50099247	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:50099247C>T	ENST00000418929.2	+	4	1667	c.1655C>T	c.(1654-1656)tCc>tTc	p.S552F		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	325	Pro-rich.						DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		GGACCCAGCTCCCTGGGAGGC	0.711000													39	32					0	0	0.00148497	0	0
SYNDIG1	79953	broad.mit.edu	37	20	24565606	24565606	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr20:24565606G>A	ENST00000376862.3	+	3	1228	c.595G>A	c.(595-597)Gca>Aca	p.A199T	SYNDIG1_ENST00000482637.1_3'UTR	NM_024893.1	NP_079169.1	Q9H7V2	SYNG1_HUMAN	synapse differentiation inducing 1	199					response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane				breast(2)|endometrium(1)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	24						TCTGGGCATCGCAGCCTTCTA	0.617000													57	54					0	0	0.000781405	0	0
TOMM40	10452	broad.mit.edu	37	19	45394827	45394827	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:45394827G>A	ENST00000592434.1	+	2	248	c.155G>A	c.(154-156)cGa>cAa	p.R52Q	TOMM40_ENST00000252487.5_Missense_Mutation_p.R52Q|TOMM40_ENST00000405636.2_Missense_Mutation_p.R52Q|TOMM40_ENST00000426677.2_Missense_Mutation_p.R52Q			O96008	TOM40_HUMAN	translocase of outer mitochondrial membrane 40 homolog (yeast)	52					protein targeting to mitochondrion	integral to membrane of membrane fraction|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex|pore complex	porin activity|protein transmembrane transporter activity|voltage-gated anion channel activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|ovary(1)	5	Lung NSC(12;0.0018)|all_lung(12;0.00481)			OV - Ovarian serous cystadenocarcinoma(262;0.0033)|Epithelial(262;0.176)		AGTACGAGTCGAAGTTCGGAA	0.766000													13	14					0	0	0.00244969	0	0
AGA	175	broad.mit.edu	37	4	178352882	178352882	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr4:178352882C>T	ENST00000264595.2	-	9	1148	c.1021G>A	c.(1021-1023)Gaa>Aaa	p.E341K		NM_000027.3|NM_001171988.1	NP_000018.2|NP_001165459.1	P20933	ASPG_HUMAN	aspartylglucosaminidase	341					asparagine catabolic process via L-aspartate|protein deglycosylation|protein maturation	endoplasmic reticulum|intermediate filament cytoskeleton|lysosome|microtubule cytoskeleton	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity			endometrium(1)|kidney(2)|large_intestine(6)|lung(5)|skin(2)	16		all_lung(41;1.27e-09)|Lung NSC(41;1.1e-08)|Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Hepatocellular(41;0.148)|all_neural(102;0.164)|Colorectal(36;0.245)		all cancers(43;1.37e-22)|Epithelial(43;3.86e-20)|OV - Ovarian serous cystadenocarcinoma(60;3.8e-11)|Colorectal(24;6.98e-05)|GBM - Glioblastoma multiforme(59;0.000362)|COAD - Colon adenocarcinoma(29;0.000462)|STAD - Stomach adenocarcinoma(60;0.0029)|LUSC - Lung squamous cell carcinoma(193;0.0328)|READ - Rectum adenocarcinoma(43;0.163)		TCCACTTTTTCCTCAGTTGGC	0.368000													16	12					0	0	0.000566183	0	0
CLCN3	1182	broad.mit.edu	37	4	170610194	170610194	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr4:170610194G>A	ENST00000513761.1	+	5	978	c.418_splice	c.e5-1	p.G140_splice	CLCN3_ENST00000504131.2_Splice_Site_p.G123_splice|CLCN3_ENST00000347613.4_Splice_Site_p.G140_splice|CLCN3_ENST00000360642.3_Splice_Site_p.G140_splice	NM_001829.3	NP_001820.2	P51790	CLCN3_HUMAN	chloride channel, voltage-sensitive 3	140					endosomal lumen acidification	cell surface|early endosome membrane|Golgi membrane|integral to membrane|late endosome membrane|transport vesicle membrane	antiporter activity|ATP binding|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|voltage-gated chloride channel activity			breast(5)|endometrium(3)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	29		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0233)|LUSC - Lung squamous cell carcinoma(193;0.131)		GTTTTTATAGGGGCACTGGCC	0.423000													29	77					0	0	0.00178596	0	0
GLT6D1	360203	broad.mit.edu	37	9	138517996	138517996	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr9:138517996C>T	ENST00000371763.1	-	4	429	c.176G>A	c.(175-177)gGg>gAg	p.G59E		NM_182974.2	NP_892019.2	Q7Z4J2	GL6D1_HUMAN	glycosyltransferase 6 domain containing 1	59					carbohydrate metabolic process	integral to membrane	transferase activity, transferring hexosyl groups			endometrium(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	15		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;4.3e-07)|Epithelial(140;1.58e-06)|all cancers(34;5.36e-05)		GTCGAAAGTCCCTTCCCATAG	0.507000													23	29					0	0	0.000586117	0	0
PCYT1A	5130	broad.mit.edu	37	3	195984731	195984731	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr3:195984731C>T	ENST00000292823.2	-	4	317	c.145G>A	c.(145-147)Gat>Aat	p.D49N	PCYT1A_ENST00000431016.1_Missense_Mutation_p.D49N|PCYT1A_ENST00000491544.1_5'UTR|PCYT1A_ENST00000419333.1_Missense_Mutation_p.D49N	NM_005017.2	NP_005008.2	P49585	PCY1A_HUMAN	phosphate cytidylyltransferase 1, choline, alpha	49						cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity			cervix(1)|endometrium(3)|large_intestine(8)|lung(5)|ovary(1)	18	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)	TCAATTTCATCAGAAAAAGGA	0.363000													14	28					0	0	0.000308642	0	0
PADI6	353238	broad.mit.edu	37	1	17720899	17720899	+	RNA	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:17720899G>A	ENST00000434762.2	+	0	1337							Q6TGC4	PADI6_HUMAN	peptidyl arginine deiminase, type VI						peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity	p.G428E(1)		breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(2)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	AAGGTCCAAGGGAAAGAGTAC	0.547000													4	9					0	0	0.00024832	0	0
NT5DC3	51559	broad.mit.edu	37	12	104192412	104192412	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr12:104192412C>T	ENST00000392876.3	-	5	608	c.568G>A	c.(568-570)Gag>Aag	p.E190K	NT5DC3_ENST00000465502.1_5'UTR	NM_001031701.2	NP_001026871.1	Q86UY8	NT5D3_HUMAN	5'-nucleotidase domain containing 3	190							hydrolase activity|metal ion binding			NS(1)|breast(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(15)|ovary(2)|skin(1)|stomach(2)	30						TGGGACCCCTCGTACATTTCA	0.423000													17	49					0	0	0.00229938	0	0
LRRN2	10446	broad.mit.edu	37	1	204588493	204588493	+	Missense_Mutation	SNP	G	G	A	rs141989916	byFrequency	TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:204588493G>A	ENST00000367175.1	-	1	2840	c.628C>T	c.(628-630)Cgg>Tgg	p.R210W	LRRN2_ENST00000367176.3_Missense_Mutation_p.R210W|LRRN2_ENST00000367177.3_Missense_Mutation_p.R210W			O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2	210					cell adhesion	integral to membrane	receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|liver(1)|lung(22)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			GCCAGGGGCCGGAAGTTCATG	0.587000													38	55					0	0	0.00222228	0	0
PRAMEF4	400735	broad.mit.edu	37	1	12939629	12939629	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:12939629G>A	ENST00000235349.5	-	4	1243	c.1173C>T	c.(1171-1173)ccC>ccT	p.P391P		NM_001009611.2	NP_001009611.1	O60810	PRAM4_HUMAN	PRAME family member 4	391										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(3)|skin(1)	24	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CCATGCAGATGGGATTTCCAC	0.527000													128	106					0	0	0.000781405	0	0
ABCG2	9429	broad.mit.edu	37	4	89034569	89034569	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr4:89034569C>T	ENST00000237612.3	-	9	1625	c.1080G>A	c.(1078-1080)aaG>aaA	p.K360K	ABCG2_ENST00000515655.1_Silent_p.K360K	NM_004827.2	NP_004818.2	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 2	360					cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			breast(5)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(13)|lung(10)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	AGACTGTGATCTTCTTCTTCT	0.433000													71	52					0	0	0.000781405	0	0
NRROS	375387	broad.mit.edu	37	3	196381500	196381500	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr3:196381500C>T	ENST00000328557.4	+	2	293	c.90C>T	c.(88-90)tcC>tcT	p.S30S		NM_198565.1	NP_940967.1			negative regulator of reactive oxygen species																		CAGCAGCCTCCCAAGGAGTCT	0.557000													13	37					0	0	0.00185496	0	0
ZNF528	84436	broad.mit.edu	37	19	52909821	52909821	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:52909821C>T	ENST00000391788.2	+	6	689	c.166C>T	c.(166-168)Ccc>Tcc	p.P56S	ZNF528_ENST00000360465.3_Missense_Mutation_p.P66S|ZNF528_ENST00000598192.1_Missense_Mutation_p.P66S|ZNF528_ENST00000594530.1_Missense_Mutation_p.P66S			Q3MIS6	ZN528_HUMAN	zinc finger protein 528	66	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.P66S(1)		breast(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(6)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	39				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		AAAGAGAGATCCCTGGACTCT	0.473000													39	37					0	0	0.0025221	0	0
MYLK	4638	broad.mit.edu	37	3	123367904	123367904	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr3:123367904C>T	ENST00000360772.3	-	27	4707	c.4329G>A	c.(4327-4329)aaG>aaA	p.K1443K	MYLK_ENST00000359169.1_Silent_p.K1443K|MYLK_ENST00000354792.5_Silent_p.K243K|MYLK_ENST00000360304.3_Silent_p.K1443K|MYLK_ENST00000346322.5_Silent_p.K1374K|MYLK_ENST00000475616.1_Silent_p.K1443K			Q15746	MYLK_HUMAN	myosin light chain kinase	1443	Actin-binding (calcium/calmodulin- insensitive) (By similarity).				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CCTCGGGCTCCTTCTCATCTG	0.542000													35	64					0	0	0.00148497	0	0
CPT1C	126129	broad.mit.edu	37	19	50209210	50209210	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:50209210C>T	ENST00000392518.4	+	11	1381	c.1009C>T	c.(1009-1011)Cac>Tac	p.H337Y	CPT1C_ENST00000354199.5_Missense_Mutation_p.H337Y|CPT1C_ENST00000598293.1_Missense_Mutation_p.H337Y|CPT1C_ENST00000323446.5_Missense_Mutation_p.H337Y|CPT1C_ENST00000405931.2_Missense_Mutation_p.H326Y	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	337					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		GGCTGTCTTCCACCGGGGCCG	0.587000													18	54					0	0	0.000720815	0	0
PRKD3	23683	broad.mit.edu	37	2	37543442	37543442	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:37543442C>T	ENST00000379066.1	-	2	988	c.226G>A	c.(226-228)Gaa>Aaa	p.E76K	PRKD3_ENST00000234179.2_Missense_Mutation_p.E76K			O94806	KPCD3_HUMAN	protein kinase D3	76					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			breast(3)|central_nervous_system(2)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.21)				TCCTGGGCTTCAATGGTAACA	0.428000													45	94					0	0	0.000781405	0	0
HK3	3101	broad.mit.edu	37	5	176309021	176309021	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr5:176309021C>T	ENST00000292432.5	-	16	2252	c.2161G>A	c.(2161-2163)Gat>Aat	p.D721N		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	721	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGAGAGCCATCGTCCCCAAAG	0.642000													56	32					0	0	0.000781405	0	0
OR1G1	8390	broad.mit.edu	37	17	3030271	3030271	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr17:3030271G>A	ENST00000328890.2	-	1	604	c.575C>T	c.(574-576)cCc>cTc	p.P192L		NM_003555.1	NP_003546.1	P47890	OR1G1_HUMAN	olfactory receptor, family 1, subfamily G, member 1	192					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(3)|skin(3)	11						ATTGGTGAAGGGGTCTGTGCA	0.498000													56	58					0	0	0.000781405	0	0
CLRN1	7401	broad.mit.edu	37	3	150690318	150690318	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr3:150690318C>T	ENST00000327047.1	-	1	468	c.178G>A	c.(178-180)Gaa>Aaa	p.E60K	RP11-166N6.2_ENST00000469268.1_RNA|CLRN1_ENST00000328863.4_Missense_Mutation_p.E60K|CLRN1-AS1_ENST00000476886.1_RNA	NM_174878.2	NP_777367.1	P58418	CLRN1_HUMAN	clarin 1	60					equilibrioception|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	integral to membrane				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)	14			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			TACTGCATTTCACCCATAAAC	0.532000													46	33					0	0	0.000680045	0	0
GPR182	11318	broad.mit.edu	37	12	57389082	57389082	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr12:57389082C>T	ENST00000300098.1	+	2	308	c.89C>T	c.(88-90)aCc>aTc	p.T30I		NM_007264.3	NP_009195.1	O15218	GP182_HUMAN	G protein-coupled receptor 182	30						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	15						CACAACTGGACCGAGCTGCTT	0.612000													33	39					0	0	0.000814825	0	0
SF3B3	23450	broad.mit.edu	37	16	70572248	70572248	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr16:70572248G>A	ENST00000302516.5	+	7	1059	c.848G>A	c.(847-849)aGa>aAa	p.R283K		NM_012426.4	NP_036558.3	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3, 130kDa	283					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			breast(2)|endometrium(8)|kidney(2)|large_intestine(8)|liver(3)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	53		Ovarian(137;0.0694)				GACCCTGAAAGAGGAATGATT	0.388000													34	99					0	0	0.00148497	0	0
KDM3A	55818	broad.mit.edu	37	2	86711207	86711207	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:86711207T>C	ENST00000409556.1	+	20	3385	c.3020T>C	c.(3019-3021)gTt>gCt	p.V1007A	KDM3A_ENST00000312912.5_Missense_Mutation_p.V1007A|KDM3A_ENST00000542128.1_Missense_Mutation_p.V955A|KDM3A_ENST00000409064.1_Missense_Mutation_p.V1007A			Q9Y4C1	KDM3A_HUMAN	lysine (K)-specific demethylase 3A	1007					androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(3)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(3)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	47						GTAGACCTAGTTAATTGTAGG	0.418000													36	45					0	0	0.000814825	0	0
AKT1	207	broad.mit.edu	37	14	105241328	105241328	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr14:105241328G>A	ENST00000554581.1	-	6	2060	c.580C>T	c.(580-582)Cac>Tac	p.H194Y	AKT1_ENST00000554848.1_Missense_Mutation_p.H194Y|AKT1_ENST00000544168.1_Missense_Mutation_p.H132Y|AKT1_ENST00000407796.2_Missense_Mutation_p.H194Y|AKT1_ENST00000402615.2_Missense_Mutation_p.H194Y|AKT1_ENST00000349310.3_Missense_Mutation_p.H194Y|AKT1_ENST00000555528.1_Missense_Mutation_p.H194Y			P31749	AKT1_HUMAN	v-akt murine thymoma viral oncogene homolog 1	194	Protein kinase.				activation of pro-apoptotic gene products|activation-induced cell death of T cells|endocrine pancreas development|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen biosynthetic process|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|mRNA metabolic process|negative regulation of fatty acid beta-oxidation|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|nitric oxide biosynthetic process|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of blood vessel endothelial cell migration|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of establishment of protein localization in plasma membrane|positive regulation of fat cell differentiation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein autophosphorylation|protein import into nucleus, translocation|regulation of neuron projection development|regulation of translation|response to fluid shear stress|response to heat|response to UV-A|T cell costimulation	cytosol|nucleoplasm|plasma membrane	enzyme binding|identical protein binding|nitric-oxide synthase regulator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein serine/threonine kinase activity			NS(3)|breast(97)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(7)|lung(10)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|thyroid(10)|urinary_tract(15)	176		all_cancers(154;3.77e-06)|all_lung(585;3.24e-07)|all_epithelial(191;3.45e-05)|all_neural(303;0.0459)|Melanoma(154;0.155)	all cancers(16;0.000486)|OV - Ovarian serous cystadenocarcinoma(23;0.00647)|Epithelial(46;0.0153)|GBM - Glioblastoma multiforme(11;0.116)	all cancers(159;0.0107)|OV - Ovarian serous cystadenocarcinoma(161;0.0132)|Epithelial(152;0.243)	Adenosine triphosphate(DB00171)|Arsenic trioxide(DB01169)	GTGAGTGTGTGGGCCACCTCG	0.672000		1	Mis		"""breast, colorectal, ovarian, NSCLC"""								23	13					0	0	0.00278032	0	0
SH3BP4	23677	broad.mit.edu	37	2	235951888	235951888	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:235951888G>A	ENST00000409212.1	+	4	2982	c.2475G>A	c.(2473-2475)gtG>gtA	p.V825V	SH3BP4_ENST00000392011.2_Silent_p.V825V|SH3BP4_ENST00000344528.4_Silent_p.V825V			Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	825					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(6)|stomach(3)|urinary_tract(2)	44		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		AGGAGCTTGTGATGGTGAGTG	0.577000													27	35					0	0	0.001512	0	0
NLRP12	91662	broad.mit.edu	37	19	54312870	54312870	+	Silent	SNP	G	G	A	rs141711127	by1000genomes	TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:54312870G>A	ENST00000324134.6	-	3	2211	c.2043C>T	c.(2041-2043)tcC>tcT	p.S681S	NLRP12_ENST00000351894.4_Silent_p.S681S|NLRP12_ENST00000354278.3_Silent_p.S681S|NLRP12_ENST00000391772.1_Silent_p.S681S|NLRP12_ENST00000535162.1_Silent_p.S681S|NLRP12_ENST00000391775.3_Silent_p.S681S|NLRP12_ENST00000345770.5_Silent_p.S681S|NLRP12_ENST00000391773.1_Silent_p.S681S	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	681					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		GCGCTCCTGCGGAGCACCTCG	0.567000													16	20					0	0	0.000422831	0	0
OR4C3	256144	broad.mit.edu	37	11	48347057	48347057	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr11:48347057C>T	ENST00000319856.4	+	1	586	c.565C>T	c.(565-567)Ctt>Ttt	p.L189F		NM_001004702.1	NP_001004702.1	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C, member 3	162					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	32						CCTCCTGGTCCTTTGGTTGCC	0.517000													9	96					0	0	0.00229938	0	0
ZMYND15	84225	broad.mit.edu	37	17	4644204	4644204	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr17:4644204G>A	ENST00000433935.1	+	2	418	c.361G>A	c.(361-363)Gaa>Aaa	p.E121K	ZMYND15_ENST00000592813.1_Missense_Mutation_p.E121K|ZMYND15_ENST00000573751.2_Missense_Mutation_p.E121K|ZMYND15_ENST00000269289.6_Missense_Mutation_p.E121K	NM_001136046.2|NM_001267822.1	NP_001129518.1|NP_001254751.1	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15	121	Glu-rich.						zinc ion binding			endometrium(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)	18						ggaagaggaggaagatgaaga	0.602000													9	10					0	0	0.000274275	0	0
PCDHGA11	56105	broad.mit.edu	37	5	140801371	140801371	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr5:140801371C>T	ENST00000398587.2	+	1	610	c.577C>T	c.(577-579)Cca>Tca	p.P193S	PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA11_ENST00000518882.1_Missense_Mutation_p.P193S|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018914.2|NM_032092.1	NP_061737.1|NP_114481.1														breast(3)|endometrium(8)|kidney(3)|large_intestine(9)|lung(22)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCCAAGAATCCAGAGCTAGT	0.567000													18	8					0	0	0.000958276	0	0
SERPINF1	5176	broad.mit.edu	37	17	1674330	1674330	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr17:1674330G>A	ENST00000254722.4	+	4	454	c.291G>A	c.(289-291)gaG>gaA	p.E97E	SERPINF1_ENST00000571870.1_3'UTR	NM_002615.5	NP_002606.3	P36955	PEDF_HUMAN	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	97				EQ -> DE (in Ref. 1; AAA60058 and 9; AAB38685).	cell proliferation|negative regulation of angiogenesis|positive regulation of neurogenesis|regulation of proteolysis	extracellular space|melanosome	serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(2)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	16						CAGGAGCGGAGCAGCGAACAG	0.517000													61	75					0	0	0.000781405	0	0
EFTUD1	79631	broad.mit.edu	37	15	82520603	82520603	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr15:82520603C>T	ENST00000268206.7	-	10	1166	c.998G>A	c.(997-999)cGa>cAa	p.R333Q	EFTUD1_ENST00000561331.1_5'UTR|EFTUD1_ENST00000359445.3_Missense_Mutation_p.R282Q	NM_024580.5	NP_078856.4	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain containing 1	333					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32						GTCTGAATGTCGTGCCTCCCG	0.408000													22	35					0	0	0.00229938	0	0
RAD23A	5886	broad.mit.edu	37	19	13063580	13063580	+	Silent	SNP	G	G	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:13063580G>T	ENST00000586534.1	+	8	952	c.891G>T	c.(889-891)gtG>gtT	p.V297V	RAD23A_ENST00000316856.3_Silent_p.V296V|RAD23A_ENST00000541222.1_Silent_p.V132V|RAD23A_ENST00000592268.1_Intron			P54725	RD23A_HUMAN	RAD23 homolog A (S. cerevisiae)	297					interspecies interaction between organisms|nucleotide-excision repair|positive regulation of viral genome replication|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)	12						TCTCAGATGTGGAGGGGGAGG	0.617000								Nucleotide excision repair (NER)					20	59					1.55795e-14	6.75256e-14	0.00188189	1	0
ATXN7	6314	broad.mit.edu	37	3	63973962	63973962	+	Silent	SNP	A	A	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr3:63973962A>T	ENST00000398590.3	+	9	1876	c.1323A>T	c.(1321-1323)gtA>gtT	p.V441V	ATXN7_ENST00000538065.1_Silent_p.V441V|ATXN7_ENST00000295900.6_Silent_p.V441V|ATXN7_ENST00000484332.1_Silent_p.V296V|ATXN7_ENST00000487717.1_Silent_p.V441V	NM_001177387.1	NP_001170858.1	O15265	ATX7_HUMAN	ataxin 7	441	Pro-rich.				cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(12)|prostate(2)|stomach(1)|urinary_tract(3)	35		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		AGCCTTTTGTAGCTAGTAAAC	0.537000													28	63					0	0	0.00106085	0	0
MIR409	574413	broad.mit.edu	37	14	101531680	101531680	+	RNA	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr14:101531680G>A	ENST00000362237.1	+	0	44					NR_029975.1																						GCATCTGGACGACGAATGTTG	0.592000													21	29					0	0	0.00278032	0	0
GK2	2712	broad.mit.edu	37	4	80329315	80329315	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr4:80329315C>T	ENST00000358842.3	-	1	57	c.40G>A	c.(40-42)Gga>Aga	p.G14R		NM_033214.2	NP_149991.2	Q14410	GLPK2_HUMAN	glycerol kinase 2	14					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			autonomic_ganglia(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	39						ACCACCGCTCCCACCAACGGC	0.557000													8	17					0	0	0.000274275	0	0
ISCA2	122961	broad.mit.edu	37	14	74961672	74961672	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr14:74961672C>T	ENST00000556816.1	+	4	489	c.434C>T	c.(433-435)tCc>tTc	p.S145F	ISCA2_ENST00000554924.1_3'UTR|ISCA2_ENST00000298818.8_3'UTR			Q86U28	ISCA2_HUMAN	iron-sulfur cluster assembly 2	145					iron-sulfur cluster assembly	mitochondrion	iron-sulfur cluster binding|metal ion binding|structural molecule activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00146)		CAAGGCTGCTCCTGTGGGTCA	0.463000													41	42					0	0	0.00222228	0	0
FARSB	10056	broad.mit.edu	37	2	223436631	223436631	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:223436631G>A	ENST00000281828.6	-	17	1992	c.1729C>T	c.(1729-1731)Ccc>Tcc	p.P577S	FARSB_ENST00000536361.1_Missense_Mutation_p.P478S	NM_005687.3	NP_005678.3	Q9NSD9	SYFB_HUMAN	phenylalanyl-tRNA synthetase, beta subunit	577					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	24		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)	GAGGAGCAGGGCATGGTCAGC	0.527000													16	26					0	0	0.000566183	0	0
FSD2	123722	broad.mit.edu	37	15	83451553	83451553	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr15:83451553G>A	ENST00000334574.8	-	4	1141	c.960C>T	c.(958-960)ttC>ttT	p.F320F	FSD2_ENST00000541889.1_Silent_p.F320F			A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing 2	320										breast(2)|central_nervous_system(1)|large_intestine(5)|lung(10)	18						TGACCTTTATGAAATCCACCT	0.378000													125	182					0	0	0.000781405	0	0
LILRB5	10990	broad.mit.edu	37	19	54754843	54754843	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:54754843A>G	ENST00000450632.1	-	13	1869	c.1792T>C	c.(1792-1794)Tcc>Ccc	p.S598P	LILRB5_ENST00000316219.5_Intron|LILRB5_ENST00000345866.6_Intron|LILRB5_ENST00000449561.2_Intron			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	423					cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGGGGTGGGGAGGCCTGGGGG	0.607000													5	27					0	0	0.000602214	0	0
TMEM56	148534	broad.mit.edu	37	1	95609521	95609521	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:95609521C>T	ENST00000370203.4	+	2	355	c.64C>T	c.(64-66)Ctt>Ttt	p.L22F	TMEM56_ENST00000463375.1_3'UTR|RP11-57H12.6_ENST00000604534.1_Missense_Mutation_p.L22F	NM_001199679.1|NM_152487.2	NP_001186608.1|NP_689700.1	Q96MV1	TMM56_HUMAN	transmembrane protein 56	22						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(2)|skin(1)|urinary_tract(1)	12		all_lung(203;0.0232)|Lung NSC(277;0.0739)		all cancers(265;0.133)		CTTTCAGCTTCTTTTCTACTT	0.348000													20	47					0	0	0.00188189	0	0
RIF1	55183	broad.mit.edu	37	2	152273114	152273114	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:152273114C>T	ENST00000243326.4	+	4	803	c.320C>T	c.(319-321)aCc>aTc	p.T107I	RIF1_ENST00000430328.2_Missense_Mutation_p.T107I|RIF1_ENST00000444746.2_Missense_Mutation_p.T107I|RIF1_ENST00000433166.2_Missense_Mutation_p.T107I|RIF1_ENST00000428287.2_Missense_Mutation_p.T107I|RIF1_ENST00000453091.2_Missense_Mutation_p.T107I			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)	107					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		TTGAATGATACCATTAAGAAT	0.333000													117	131					0	0	0.000781405	0	0
KIAA1549	57670	broad.mit.edu	37	7	138554416	138554416	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr7:138554416G>A	ENST00000440172.1	-	14	4691	c.4643C>T	c.(4642-4644)cCg>cTg	p.P1548L	KIAA1549_ENST00000422774.1_Missense_Mutation_p.P1548L|KIAA1549_ENST00000242365.4_Missense_Mutation_p.P1498L	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	1548						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						GTCTACCACCGGGAACTCGTA	0.637000			O	BRAF	pilocytic astrocytoma								9	12					0	0	0.000274275	0	0
HERC2	8924	broad.mit.edu	37	15	28366576	28366576	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr15:28366576C>T	ENST00000261609.7	-	86	13297		c.e86-1			NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2						DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		AAGCCGCCTCCTAAAACACAT	0.438000													25	24					0	0	0.00106085	0	0
POLR1B	84172	broad.mit.edu	37	2	113325561	113325561	+	Silent	SNP	A	A	G			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:113325561A>G	ENST00000263331.5	+	11	2344	c.1764A>G	c.(1762-1764)agA>agG	p.R588R	POLR1B_ENST00000541869.1_Silent_p.R626R|POLR1B_ENST00000417433.2_Silent_p.R532R|POLR1B_ENST00000537335.1_Silent_p.R377R|POLR1B_ENST00000409894.3_Silent_p.R405R	NM_019014.4	NP_061887.2	Q9H9Y6	RPA2_HUMAN	polymerase (RNA) I polypeptide B, 128kDa	588					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(3)|endometrium(9)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42						GAGAGAAAAGAATTCCTCCCT	0.463000													21	34					0	0	0.00229938	0	0
CR2	1380	broad.mit.edu	37	1	207648498	207648498	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:207648498C>T	ENST00000367057.3	+	14	2842	c.2653C>T	c.(2653-2655)Cgc>Tgc	p.R885C	CR2_ENST00000367058.3_Missense_Mutation_p.R826C|CR2_ENST00000458541.2_Missense_Mutation_p.R799C|CR2_ENST00000367059.3_Missense_Mutation_p.R826C	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	951	Sushi 14.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						GAATGGTAGTCGCGTGATTAG	0.408000													71	19					0	0	0.000781405	0	0
NACA	4666	broad.mit.edu	37	12	57110989	57110989	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr12:57110989G>A	ENST00000454682.1	-	3	4606	c.4325C>T	c.(4324-4326)tCc>tTc	p.S1442F	NACA_ENST00000548563.1_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000550952.1_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000551793.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						CTTTTTGAGGGAGACAGGAGT	0.612000			T	BCL6	NHL								17	12					0	0	0.00074312	0	0
KNDC1	85442	broad.mit.edu	37	10	135000066	135000066	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr10:135000066C>T	ENST00000304613.3	+	6	1235	c.1214C>T	c.(1213-1215)cCa>cTa	p.P405L	KNDC1_ENST00000368571.2_Missense_Mutation_p.P340L|KNDC1_ENST00000368572.2_Missense_Mutation_p.P405L			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	405					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		AGCCAGGGGCCAGCAGAGGCC	0.662000													11	29					0	0	0.000978159	0	0
SPIN1	10927	broad.mit.edu	37	9	91077425	91077425	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr9:91077425G>T	ENST00000375859.3	+	4	394	c.116G>T	c.(115-117)aGt>aTt	p.S39I	SPIN1_ENST00000469017.2_3'UTR|SPIN1_ENST00000541629.1_Missense_Mutation_p.S39I	NM_006717.2	NP_006708.2	Q9Y657	SPIN1_HUMAN	spindlin 1	39					cell cycle|gamete generation|multicellular organismal development	nucleus	methylated histone residue binding			endometrium(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	4						CATCGGAGCAGTGTGGGTCCG	0.498000													31	56					4.62619e-21	2.02216e-20	0.000814825	1	0
WDR93	56964	broad.mit.edu	37	15	90280818	90280818	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr15:90280818C>T	ENST00000268130.7	+	15	1724	c.1623C>T	c.(1621-1623)tcC>tcT	p.S541S	WDR93_ENST00000560294.1_Silent_p.S513S|WDR93_ENST00000444934.2_Silent_p.S258S	NM_020212.1	NP_064597.1	Q6P2C0	WDR93_HUMAN	WD repeat domain 93	541					electron transport chain	mitochondrial inner membrane	oxidoreductase activity, acting on NADH or NADPH			NS(1)|breast(3)|endometrium(2)|kidney(4)|large_intestine(5)|liver(2)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	33	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			TCATCTTTTCCAAGAATGGCT	0.557000													60	67					0	0	0.000781405	0	0
SLC22A9	114571	broad.mit.edu	37	11	63141223	63141223	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr11:63141223T>C	ENST00000279178.3	+	3	863	c.614T>C	c.(613-615)tTg>tCg	p.L205S	SLC22A9_ENST00000310969.4_Intron	NM_080866.2	NP_543142.2	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion transporter), member 9	205					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						CTACGCTTCTTGTCTGGGATT	0.443000													59	79					0	0	0.000781405	0	0
AGO4	192670	broad.mit.edu	37	1	36315797	36315797	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:36315797G>A	ENST00000373210.3	+	16	2460	c.2215G>A	c.(2215-2217)Gat>Aat	p.D739N	AGO4_ENST00000488778.1_3'UTR	NM_017629.3	NP_060099.2			argonaute RISC catalytic component 4																		CACTACAGTGGATAGTACCAT	0.403000													55	41					0	0	0.000781405	0	0
FMN2	56776	broad.mit.edu	37	1	240341256	240341256	+	Silent	SNP	A	A	G			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:240341256A>G	ENST00000319653.9	+	3	2048	c.1818A>G	c.(1816-1818)caA>caG	p.Q606Q	RP11-567G24.3_ENST00000412311.1_RNA|RP11-567G24.3_ENST00000444308.1_RNA	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	606					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CAGTTAGTCAACCCACACACT	0.418000													16	6					0	0	0.000566183	0	0
FMO5	2330	broad.mit.edu	37	1	146658801	146658801	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:146658801G>A	ENST00000254090.4	-	9	1668	c.1280C>T	c.(1279-1281)aCc>aTc	p.T427I	FMO5_ENST00000369272.3_3'UTR|RP11-337C18.8_ENST00000607149.1_RNA|FMO5_ENST00000441068.2_Intron	NM_001461.2	NP_001452.2	P49326	FMO5_HUMAN	flavin containing monooxygenase 5	427						integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(9)|ovary(3)|upper_aerodigestive_tract(1)	25	all_hematologic(923;0.0487)					TCCCTGAATGGTATGGCGTTG	0.483000													12	4					0	0	0.00185496	0	0
SAMD9	54809	broad.mit.edu	37	7	92732256	92732256	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr7:92732256G>A	ENST00000379958.2	-	3	3424	c.3155C>T	c.(3154-3156)tCc>tTc	p.S1052F		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1052						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			AATAAATGGGGAAAACCAATT	0.383000													28	56					0	0	0.00178596	0	0
NET1	10276	broad.mit.edu	37	10	5494349	5494349	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr10:5494349C>T	ENST00000355029.4	+	5	534	c.392C>T	c.(391-393)tCc>tTc	p.S131F	NET1_ENST00000542715.1_5'UTR|NET1_ENST00000380359.3_Missense_Mutation_p.S77F	NM_001047160.1	NP_001040625.1	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming 1	131					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity			breast(4)|kidney(2)|large_intestine(9)|lung(5)|prostate(2)|skin(1)	23						GACCACAGATCCCCAGCCTCT	0.433000													15	2					0	0	0.00074312	0	0
FAM129C	199786	broad.mit.edu	37	19	17648261	17648261	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:17648261C>T	ENST00000335393.4	+	6	735	c.597C>T	c.(595-597)ttC>ttT	p.F199F	FAM129C_ENST00000449408.2_5'UTR|FAM129C_ENST00000352727.3_Silent_p.F199F|FAM129C_ENST00000599124.1_Silent_p.F168F|FAM129C_ENST00000597887.1_3'UTR|FAM129C_ENST00000599164.1_Silent_p.F168F|FAM129C_ENST00000300971.2_Silent_p.F199F|FAM129C_ENST00000332386.5_Silent_p.F199F|FAM129C_ENST00000600871.1_Silent_p.F145F|FAM129C_ENST00000601861.1_Silent_p.F168F|FAM129C_ENST00000595684.1_Silent_p.F199F	NM_173544.4	NP_775815.2	Q86XR2	NIBL2_HUMAN	family with sequence similarity 129, member C	199										autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(2)|lung(14)|ovary(1)|skin(3)|stomach(1)	33						AGCACCCCTTCCGCCGGCACC	0.617000													51	69					0	0	0.000781405	0	0
SLC6A3	6531	broad.mit.edu	37	5	1414876	1414876	+	Silent	SNP	G	G	A	rs28363072		TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr5:1414876G>A	ENST00000270349.9	-	8	1213	c.1086C>T	c.(1084-1086)ttC>ttT	p.F362F	SLC6A3_ENST00000453492.2_Silent_p.F362F	NM_001044.4	NP_001035.1	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 3	362					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(19)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	AGAAGACGACGAAGCCGGAGG	0.617000													16	17					0	0	0.000958276	0	0
RP1	6101	broad.mit.edu	37	8	55538985	55538985	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr8:55538985G>A	ENST00000220676.1	+	4	2691	c.2543G>A	c.(2542-2544)aGa>aAa	p.R848K		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	848					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GGGTATTTGAGAGGAATGGCA	0.348000													28	31					0	0	0.00127121	0	0
CACNA1C	775	broad.mit.edu	37	12	2602424	2602424	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr12:2602424G>A	ENST00000399655.1	+	7	1250	c.985G>A	c.(985-987)Ggc>Agc	p.G329S	CACNA1C_ENST00000344100.3_Missense_Mutation_p.G329S|CACNA1C_ENST00000399595.1_Missense_Mutation_p.G329S|CACNA1C_ENST00000347598.4_Missense_Mutation_p.G329S|CACNA1C_ENST00000335762.5_Missense_Mutation_p.G329S|CACNA1C_ENST00000399641.1_Missense_Mutation_p.G329S|CACNA1C_ENST00000399649.1_Missense_Mutation_p.G329S|CACNA1C_ENST00000399601.1_Missense_Mutation_p.G329S|CACNA1C_ENST00000399629.1_Missense_Mutation_p.G329S|CACNA1C_ENST00000399606.1_Missense_Mutation_p.G329S|CACNA1C_ENST00000399603.1_Missense_Mutation_p.G329S|CACNA1C_ENST00000480911.1_Missense_Mutation_p.G329S|CACNA1C_ENST00000399634.1_Missense_Mutation_p.G329S|CACNA1C_ENST00000399644.1_Missense_Mutation_p.G329S|CACNA1C_ENST00000399597.1_Missense_Mutation_p.G329S|CACNA1C_ENST00000327702.7_Missense_Mutation_p.G329S|CACNA1C_ENST00000399621.1_Missense_Mutation_p.G329S|CACNA1C_ENST00000402845.3_Missense_Mutation_p.G329S|CACNA1C_ENST00000399617.1_Missense_Mutation_p.G329S|CACNA1C_ENST00000399591.1_Missense_Mutation_p.G329S|CACNA1C_ENST00000406454.3_Missense_Mutation_p.G329S|CACNA1C_ENST00000399638.1_Missense_Mutation_p.G329S|CACNA1C_ENST00000399637.1_Missense_Mutation_p.G329S	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	329					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GTGCCAGAACGGCACGGTGTG	0.587000													27	77					0	0	0.001512	0	0
STAB1	23166	broad.mit.edu	37	3	52549479	52549479	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr3:52549479C>T	ENST00000321725.6	+	37	3981	c.3905C>T	c.(3904-3906)tCc>tTc	p.S1302F		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	1302					cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		TCTGGCTTCTCCTTCTCCCGG	0.617000													13	30					0	0	0.000308642	0	0
CACNA1B	774	broad.mit.edu	37	9	140809147	140809147	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr9:140809147C>T	ENST00000371372.1	+	5	809	c.664C>T	c.(664-666)Cca>Tca	p.P222S	CACNA1B_ENST00000371357.1_Missense_Mutation_p.P222S|CACNA1B_ENST00000371355.4_Missense_Mutation_p.P222S|CACNA1B_ENST00000371363.1_Missense_Mutation_p.P222S|CACNA1B_ENST00000277549.5_5'UTR|CACNA1B_ENST00000277551.2_Missense_Mutation_p.P222S	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	222					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	GGCCATGGTTCCACTCCTGCA	0.547000													12	11					0	0	0.00136819	0	0
ANO4	121601	broad.mit.edu	37	12	101520688	101520688	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr12:101520688C>T	ENST00000392979.3	+	26	2964	c.2603C>T	c.(2602-2604)tCa>tTa	p.S868L	ANO4_ENST00000392977.3_Missense_Mutation_p.S903L|ANO4_ENST00000550015.1_Missense_Mutation_p.S423L|ANO4_ENST00000299222.9_Missense_Mutation_p.S423L	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	903						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						CACCTCATTTCATATCTGATC	0.443000										HNSCC(74;0.22)			9	18					0	0	0.000274275	0	0
TTLL12	23170	broad.mit.edu	37	22	43579110	43579110	+	Missense_Mutation	SNP	C	C	T	rs143398079		TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr22:43579110C>T	ENST00000216129.6	-	2	286	c.223G>A	c.(223-225)Gta>Ata	p.V75I		NM_015140.3	NP_055955.1	Q14166	TTL12_HUMAN	tubulin tyrosine ligase-like family, member 12	75					protein modification process		tubulin-tyrosine ligase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)	13		Ovarian(80;0.221)|Glioma(61;0.222)				TCCTCTTCTACCTCCTCCACT	0.637000													55	79					0	0	0.000781405	0	0
MACF1	23499	broad.mit.edu	37	1	39835860	39835860	+	Splice_Site	SNP	T	T	C			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:39835860T>C	ENST00000564288.1	+	51	13872		c.e51+2		MACF1_ENST00000539005.1_Splice_Site|MACF1_ENST00000372915.3_Splice_Site|MACF1_ENST00000317713.7_Splice_Site|MACF1_ENST00000361689.2_Splice_Site|MACF1_ENST00000545844.1_Splice_Site|MACF1_ENST00000476350.1_Splice_Site|MACF1_ENST00000289893.4_Splice_Site|MACF1_ENST00000567887.1_Splice_Site			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1						cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CACCTGAAGGTAGGTGAACAA	0.428000													10	6					0	0	0.000442599	0	0
MORC1	27136	broad.mit.edu	37	3	108723684	108723684	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr3:108723684C>T	ENST00000232603.5	-	20	2147	c.2065G>A	c.(2065-2067)Ggg>Agg	p.G689R	MORC1_ENST00000483760.1_Missense_Mutation_p.G668R	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	689					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						TTCAGGCACCCTTCAGTTGGT	0.348000													142	121					0	0	0.000781405	0	0
MYH9	4627	broad.mit.edu	37	22	36698686	36698686	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr22:36698686C>T	ENST00000216181.5	-	20	2657	c.2427G>A	c.(2425-2427)atG>atA	p.M809I		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	809					actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						GGAGGACCTTCATGGCGGTAA	0.612000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				33	36					0	0	0.000814825	0	0
ADRM1	11047	broad.mit.edu	37	20	60882796	60882796	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr20:60882796C>T	ENST00000253003.2	+	7	814	c.768C>T	c.(766-768)gcC>gcT	p.A256A		NM_007002.2|NM_175573.1	NP_008933.2|NP_783163.1	Q16186	ADRM1_HUMAN	adhesion regulating molecule 1	256	Ser-rich.				proteasome assembly|transcription elongation from RNA polymerase II promoter	cytoplasm|integral to plasma membrane|membrane fraction|nucleus|proteasome complex	endopeptidase activator activity|protease binding|proteasome binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|urinary_tract(1)	5	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;2.51e-06)			GCACAGCAGCCAGCCCGACCC	0.677000													12	13					0	0	0.00136819	0	0
WASF3	10810	broad.mit.edu	37	13	27255226	27255226	+	Missense_Mutation	SNP	C	C	A	rs145774948	byFrequency	TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr13:27255226C>A	ENST00000361042.4	+	8	968	c.743C>A	c.(742-744)cCg>cAg	p.P248Q	WASF3_ENST00000335327.5_Missense_Mutation_p.P251Q			Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	251					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|pancreas(1)|prostate(2)|skin(2)	22	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		TACTCTTACCCGGCTACTCCC	0.517000													6	129					0.00198382	0.00836347	0.00198382	1	0
NEB	4703	broad.mit.edu	37	2	152525626	152525626	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:152525626C>T	ENST00000427231.2	-	39	4728	c.4526G>A	c.(4525-4527)gGa>gAa	p.G1509E	NEB_ENST00000604864.1_Missense_Mutation_p.G1509E|NEB_ENST00000603639.1_Missense_Mutation_p.G1509E|NEB_ENST00000397345.3_Missense_Mutation_p.G1509E|NEB_ENST00000172853.10_Missense_Mutation_p.G1509E|NEB_ENST00000409198.1_Missense_Mutation_p.G1509E	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	1509					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CAGTTTCTCTCCCTCTACCTT	0.398000													3	9					0	0	6.4e-05	0	0
UBXN4	23190	broad.mit.edu	37	2	136519433	136519433	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:136519433G>A	ENST00000272638.9	+	6	865	c.554G>A	c.(553-555)gGa>gAa	p.G185E	UBXN4_ENST00000490163.1_Intron	NM_014607.3	NP_055422.1	Q92575	UBXN4_HUMAN	UBX domain protein 4	185					response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	24						GAGCCTAGTGGATGCTCAGAT	0.383000													19	46					0	0	0.000586117	0	0
FAM83B	222584	broad.mit.edu	37	6	54804970	54804970	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr6:54804970C>T	ENST00000306858.7	+	5	1317	c.1201C>T	c.(1201-1203)Ctg>Ttg	p.L401L		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	401										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					GCCATACCTCCTGCTTAATAG	0.443000													51	34					0	0	0.000781405	0	0
NOTCH2	4853	broad.mit.edu	37	1	120497814	120497814	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:120497814G>A	ENST00000256646.2	-	13	2287	c.2068C>T	c.(2068-2070)Ccc>Tcc	p.P690S		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	690	EGF-like 18; calcium-binding (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTGCGACAGGGATTGGAGGCA	0.507000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				295	182					0	0	0.000781405	0	0
LZTFL1	54585	broad.mit.edu	37	3	45879463	45879463	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr3:45879463T>A	ENST00000296135.6	-	2	258	c.84A>T	c.(82-84)agA>agT	p.R28S	LZTFL1_ENST00000539217.1_Intron|LZTFL1_ENST00000536047.1_Missense_Mutation_p.R11S|LZTFL1_ENST00000490463.1_5'UTR	NM_001276378.1|NM_020347.2	NP_001263307.1|NP_065080.1	Q9NQ48	LZTL1_HUMAN	leucine zipper transcription factor-like 1	28										endometrium(1)|large_intestine(2)|lung(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	8				BRCA - Breast invasive adenocarcinoma(193;0.00867)|KIRC - Kidney renal clear cell carcinoma(197;0.0177)|Kidney(197;0.0208)		CAGTTTTGAGTCTCAAGCCTC	0.413000													33	20					0	0	0.000814825	0	0
PLCE1	51196	broad.mit.edu	37	10	96028694	96028694	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr10:96028694G>A	ENST00000260766.3	+	17	4924	c.4290G>A	c.(4288-4290)ttG>ttA	p.L1430L	PLCE1_ENST00000371380.2_Silent_p.L1430L|PLCE1_ENST00000371375.1_Silent_p.L1122L|PLCE1_ENST00000371385.3_Silent_p.L1122L	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	1430	PI-PLC X-box.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				AGGTCCTTTTGCAAGGCTGTC	0.498000													19	35					0	0	0.00121646	0	0
TTC6	319089	broad.mit.edu	37	14	38293143	38293143	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr14:38293143G>A	ENST00000553443.1	+	27	4955	c.4955G>A	c.(4954-4956)aGt>aAt	p.S1652N	TTC6_ENST00000476979.1_Missense_Mutation_p.S286N|TTC6_ENST00000382320.3_Missense_Mutation_p.S366N|TTC6_ENST00000267368.7_Missense_Mutation_p.S286N					tetratricopeptide repeat domain 6											central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	14	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;1.59e-06)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0543)|all cancers(34;0.108)|BRCA - Breast invasive adenocarcinoma(188;0.156)|LUSC - Lung squamous cell carcinoma(13;0.176)	GBM - Glioblastoma multiforme(112;0.00551)		GCCAGAATTAGTTTTGGCTAT	0.373000													34	20					0	0	0.00058488	0	0
LRPPRC	10128	broad.mit.edu	37	2	44203350	44203350	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:44203350C>T	ENST00000260665.7	-	6	726	c.669G>A	c.(667-669)atG>atA	p.M223I	LRPPRC_ENST00000409946.1_Missense_Mutation_p.M223I|LRPPRC_ENST00000409659.1_Missense_Mutation_p.M223I	NM_133259.3	NP_573566.2	P42704	LPPRC_HUMAN	leucine-rich pentatricopeptide repeat containing	223					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|skin(2)	41		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				CCTTAGTTTTCATAAATCCAA	0.393000													146	203					0	0	0.000781405	0	0
CSNK1E	1454	broad.mit.edu	37	22	38696771	38696771	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr22:38696771C>T	ENST00000396832.1	-	5	783	c.523G>A	c.(523-525)Ggc>Agc	p.G175S	CSNK1E_ENST00000405675.3_Missense_Mutation_p.G175S|CSNK1E_ENST00000413574.2_Missense_Mutation_p.G175S|CSNK1E_ENST00000403904.1_Missense_Mutation_p.G175S|CSNK1E_ENST00000400206.2_Missense_Mutation_p.G175S|CSNK1E_ENST00000359867.3_Missense_Mutation_p.G175S	NM_152221.2	NP_689407.1	P49674	KC1E_HUMAN	casein kinase 1, epsilon	175	Protein kinase.				DNA repair|G2/M transition of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|signal transduction	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22	Melanoma(58;0.045)					CGGGCCGTGCCGGTCAGGTTC	0.652000													32	39					0	0	0.000814825	0	0
PZP	5858	broad.mit.edu	37	12	9360928	9360928	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr12:9360928C>T	ENST00000261336.2	-	1	38	c.10G>A	c.(10-12)Gac>Aac	p.D4N		NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						AGAAGTCTGTCTTTCCGCATT	0.493000													9	13					0	0	0.000274275	0	0
GYPE	2996	broad.mit.edu	37	4	144797993	144797993	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr4:144797993T>C	ENST00000358615.4	-	3	203	c.152A>G	c.(151-153)aAt>aGt	p.N51S	GYPE_ENST00000437468.2_Missense_Mutation_p.N51S	NM_198682.2	NP_941391.2	P15421	GLPE_HUMAN	glycophorin E (MNS blood group)	51						integral to plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5	all_hematologic(180;0.158)					CGCCCACCAATTAATGAGTGT	0.358000													12	11					0	0	0.00136819	0	0
NPR3	4883	broad.mit.edu	37	5	32780897	32780897	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr5:32780897C>T	ENST00000265074.8	+	5	1608	c.1265C>T	c.(1264-1266)aCt>aTt	p.T422I	NPR3_ENST00000415685.2_Missense_Mutation_p.T206I|NPR3_ENST00000434067.2_Missense_Mutation_p.T206I|NPR3_ENST00000415167.2_Missense_Mutation_p.T422I	NM_000908.3|NM_001204375.1	NP_000899.1|NP_001191304.1	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	422					osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24					Nesiritide(DB04899)	ATTGCCATGACTGATGTGGAG	0.557000													45	70					0	0	0.000781405	0	0
USPL1	10208	broad.mit.edu	37	13	31232917	31232917	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr13:31232917G>A	ENST00000255304.4	+	9	3045	c.2703G>A	c.(2701-2703)aaG>aaA	p.K901K		NM_005800.4	NP_005791.3	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	901					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(15)|pancreas(3)|skin(3)	34		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		CAGAAAAGAAGAAATTAGCTG	0.408000													10	36					0	0	0.000442599	0	0
FAM129B	64855	broad.mit.edu	37	9	130270444	130270444	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr9:130270444C>T	ENST00000373312.3	-	12	1683	c.1470G>A	c.(1468-1470)agG>agA	p.R490R	FAM129B_ENST00000468379.1_Intron|FAM129B_ENST00000373314.3_Silent_p.R477R	NM_022833.2	NP_073744.2	Q96TA1	NIBL1_HUMAN	family with sequence similarity 129, member B	490							protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						CCCGGAAGAACCTCTTCCGCA	0.627000													31	28					0	0	0.00058488	0	0
SETBP1	26040	broad.mit.edu	37	18	42533292	42533292	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr18:42533292C>T	ENST00000282030.5	+	4	4283	c.3987C>T	c.(3985-3987)tcC>tcT	p.S1329S		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	1329						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CTTATGACTCCTCCATGTCTC	0.448000									Schinzel-Giedion syndrome				13	26					0	0	0.00244969	0	0
PKD1	5310	broad.mit.edu	37	16	2140133	2140133	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr16:2140133G>A	ENST00000262304.4	-	46	12715	c.12507C>T	c.(12505-12507)tcC>tcT	p.S4169S	PKD1_ENST00000423118.1_Silent_p.S4168S	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	4169					calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						GGGATACCTTGGAGCCCCTGG	0.692000													16	37					0	0	0.000422831	0	0
SORL1	6653	broad.mit.edu	37	11	121448004	121448004	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr11:121448004C>T	ENST00000260197.7	+	25	3604	c.3475C>T	c.(3475-3477)Cgg>Tgg	p.R1159W	SORL1_ENST00000534286.1_Missense_Mutation_p.R69W|SORL1_ENST00000532694.1_Missense_Mutation_p.R5W|SORL1_ENST00000525532.1_Missense_Mutation_p.R103W	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	1159	LDL-receptor class A 3.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GCACCAGTGCCGGAGTGACGA	0.517000													21	42					0	0	0.00152264	0	0
USP17L2	377630	broad.mit.edu	37	8	11996079	11996079	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr8:11996079G>A	ENST00000333796.3	-	1	507	c.191C>T	c.(190-192)cCc>cTc	p.P64L	FAM66D_ENST00000434078.2_RNA	NM_001256869.1|NM_001256871.1|NM_001256872.1|NM_001256873.1|NM_001256874.1|NM_201402.2	NP_001243798.1|NP_001243800.1|NP_001243801.1|NP_001243802.1|NP_001243803.1|NP_958804.2	Q6R6M4	U17L2_HUMAN	ubiquitin specific peptidase 17-like family member 2	64					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(1)|kidney(1)|large_intestine(11)|liver(1)|lung(8)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	29						CTTCTTCCTGGGAGCAAGCTG	0.567000													41	129					0	0	0.00222228	0	0
NOTCH2	4853	broad.mit.edu	37	1	120458415	120458415	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:120458415G>A	ENST00000256646.2	-	34	7149	c.6930C>T	c.(6928-6930)atC>atT	p.I2310I		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	2310					anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGCCTTTAGGGATGAGCTGGA	0.632000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				115	282					0	0	0.000781405	0	0
ACTRT1	139741	broad.mit.edu	37	X	127186092	127186092	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chrX:127186092G>A	ENST00000371124.3	-	1	290	c.94C>T	c.(94-96)Cgc>Tgc	p.R32C		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	32						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						ATGACATGGCGGGGTCCAATC	0.448000													44	7					0	0	0.0025221	0	0
HJURP	55355	broad.mit.edu	37	2	234749335	234749335	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:234749335G>A	ENST00000411486.2	-	8	2156	c.2091C>T	c.(2089-2091)tcC>tcT	p.S697S	HJURP_ENST00000441687.1_Silent_p.S612S|HJURP_ENST00000432087.1_Silent_p.S643S	NM_018410.3	NP_060880.3	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	697					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			NS(2)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(2)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		AGGCACCCAGGGAATTGCCCT	0.592000													61	78					0	0	0.000781405	0	0
BCLAF1	9774	broad.mit.edu	37	6	136597050	136597050	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr6:136597050A>T	ENST00000531224.1	-	5	1865	c.1613T>A	c.(1612-1614)aTa>aAa	p.I538K	BCLAF1_ENST00000353331.4_Missense_Mutation_p.I536K|BCLAF1_ENST00000392348.2_Missense_Mutation_p.I536K|BCLAF1_ENST00000530767.1_Missense_Mutation_p.I365K|BCLAF1_ENST00000527759.1_Missense_Mutation_p.I536K|BCLAF1_ENST00000527536.1_Missense_Mutation_p.I538K	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	538					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		ATCACTCGCTATCATTTTGAT	0.423000													31	134					0	0	0.00178596	0	0
KCNJ16	3773	broad.mit.edu	37	17	68128418	68128418	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr17:68128418A>C	ENST00000585558.1	+	4	683	c.295A>C	c.(295-297)Act>Cct	p.T99P	KCNJ16_ENST00000586462.1_Missense_Mutation_p.T103P|KCNJ16_ENST00000392671.1_Missense_Mutation_p.T64P|KCNJ16_ENST00000392670.1_Missense_Mutation_p.T64P|KCNJ16_ENST00000283936.1_Missense_Mutation_p.T64P|KCNJ16_ENST00000589377.1_Missense_Mutation_p.T64P			Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 16	64					synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	32	Breast(10;2.96e-09)					CATCTTCACCACTCTTGTGGA	0.408000													35	57					0	0	0.00058488	0	0
DHX57	90957	broad.mit.edu	37	2	39088480	39088480	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:39088480G>A	ENST00000295373.6	-	5	1198	c.1072C>T	c.(1072-1074)Cga>Tga	p.R358*	DHX57_ENST00000479345.2_5'UTR	NM_198963.1	NP_945314.1	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	358							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(20)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	62		all_hematologic(82;0.248)				TTAGAAAATCGAATTTCAAGT	0.368000													25	31					0	0	0.00047179	0	0
PSMC4	5704	broad.mit.edu	37	19	40480235	40480235	+	Silent	SNP	C	C	T	rs138214626		TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:40480235C>T	ENST00000157812.2	+	4	555	c.357C>T	c.(355-357)atC>atT	p.I119I	PSMC4_ENST00000455878.2_Silent_p.I88I	NM_006503.3|NM_153001.2	NP_006494.1|NP_694546.1	P43686	PRS6B_HUMAN	proteasome (prosome, macropain) 26S subunit, ATPase, 4	119					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TGAGCACCATCGATCGGGAGC	0.597000													19	28					0	0	0.00047179	0	0
AKT1	207	broad.mit.edu	37	14	105241329	105241329	+	Silent	SNP	G	G	A	rs139453090		TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr14:105241329G>A	ENST00000554581.1	-	6	2059	c.579C>T	c.(577-579)gcC>gcT	p.A193A	AKT1_ENST00000554848.1_Silent_p.A193A|AKT1_ENST00000544168.1_Silent_p.A131A|AKT1_ENST00000407796.2_Silent_p.A193A|AKT1_ENST00000402615.2_Silent_p.A193A|AKT1_ENST00000349310.3_Silent_p.A193A|AKT1_ENST00000555528.1_Silent_p.A193A			P31749	AKT1_HUMAN	v-akt murine thymoma viral oncogene homolog 1	193	Protein kinase.				activation of pro-apoptotic gene products|activation-induced cell death of T cells|endocrine pancreas development|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen biosynthetic process|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|mRNA metabolic process|negative regulation of fatty acid beta-oxidation|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|nitric oxide biosynthetic process|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of blood vessel endothelial cell migration|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of establishment of protein localization in plasma membrane|positive regulation of fat cell differentiation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein autophosphorylation|protein import into nucleus, translocation|regulation of neuron projection development|regulation of translation|response to fluid shear stress|response to heat|response to UV-A|T cell costimulation	cytosol|nucleoplasm|plasma membrane	enzyme binding|identical protein binding|nitric-oxide synthase regulator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein serine/threonine kinase activity			NS(3)|breast(97)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(7)|lung(10)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|thyroid(10)|urinary_tract(15)	176		all_cancers(154;3.77e-06)|all_lung(585;3.24e-07)|all_epithelial(191;3.45e-05)|all_neural(303;0.0459)|Melanoma(154;0.155)	all cancers(16;0.000486)|OV - Ovarian serous cystadenocarcinoma(23;0.00647)|Epithelial(46;0.0153)|GBM - Glioblastoma multiforme(11;0.116)	all cancers(159;0.0107)|OV - Ovarian serous cystadenocarcinoma(161;0.0132)|Epithelial(152;0.243)	Adenosine triphosphate(DB00171)|Arsenic trioxide(DB01169)	TGAGTGTGTGGGCCACCTCGT	0.672000		1	Mis		"""breast, colorectal, ovarian, NSCLC"""								23	13					0	0	0.00278032	0	0
ZNF804B	219578	broad.mit.edu	37	7	88962967	88962967	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr7:88962967C>T	ENST00000333190.4	+	4	1280	c.671C>T	c.(670-672)tCc>tTc	p.S224F		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	224						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TTTACTTTTTCCAAAAAAGTG	0.353000										HNSCC(36;0.09)			17	33					0	0	0.00074312	0	0
MEP1A	4224	broad.mit.edu	37	6	46800919	46800919	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr6:46800919G>A	ENST00000230588.4	+	11	1262	c.1253G>A	c.(1252-1254)gGa>gAa	p.G418E		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	418	MAM.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			TCAACTGGGGGAATTTACCTA	0.512000													30	36					0	0	0.00127121	0	0
CDH11	1009	broad.mit.edu	37	16	64984767	64984767	+	Silent	SNP	C	C	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr16:64984767C>A	ENST00000394156.3	-	12	2250	c.1797G>T	c.(1795-1797)ggG>ggT	p.G599G	CDH11_ENST00000268603.4_Silent_p.G599G|CDH11_ENST00000566827.1_Silent_p.G473G			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	599	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		AGAGCAGTGCCCCGTTCACGT	0.602000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			12	23					9.31168e-06	3.99109e-05	0.00185496	1	0
NXNL1	115861	broad.mit.edu	37	19	17571378	17571378	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:17571378G>A	ENST00000301944.2	-	1	385	c.301C>T	c.(301-303)Ctg>Ttg	p.L101L	CTD-2521M24.10_ENST00000594663.1_Silent_p.L8L	NM_138454.1	NP_612463.1	Q96CM4	NXNL1_HUMAN	nucleoredoxin-like 1	101	Thioredoxin.				cell redox homeostasis	nuclear outer membrane				central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	6						TCAAAGGGCAGGAAAAGCCAT	0.582000													25	30					0	0	0.00127121	0	0
TPTE	7179	broad.mit.edu	37	21	10951367	10951367	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr21:10951367G>A	ENST00000298232.7	-	9	658	c.291C>T	c.(289-291)ttC>ttT	p.F97F	TPTE_ENST00000342420.5_Silent_p.F77F|TPTE_ENST00000361285.4_Silent_p.F115F|TPTE_ENST00000415664.2_5'UTR	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	115					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGCTGTCAGTGAAAATTAGGT	0.313000													49	108					0	0	0.000781405	0	0
SEC14L4	284904	broad.mit.edu	37	22	30886109	30886109	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr22:30886109G>A	ENST00000540456.1	-	13	1354	c.1161C>T	c.(1159-1161)ccC>ccT	p.P387P	SEC14L4_ENST00000392772.2_3'UTR|SEC14L4_ENST00000381982.3_Intron|SEC14L4_ENST00000255858.7_Silent_p.P402P			Q9UDX3	S14L4_HUMAN	SEC14-like 4 (S. cerevisiae)	402						integral to membrane|intracellular	lipid binding|transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|pancreas(1)|skin(1)	21					Vitamin E(DB00163)	GTGTTGGGGAGGGTCTCATCG	0.617000													15	22					0	0	0.00074312	0	0
C4orf27	54969	broad.mit.edu	37	4	170650819	170650819	+	Silent	SNP	A	A	G			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr4:170650819A>G	ENST00000393381.2	-	8	1026	c.951T>C	c.(949-951)taT>taC	p.Y317Y		NM_017867.2	NP_060337.2	Q9NWY4	CD027_HUMAN	chromosome 4 open reading frame 27	317						nucleus				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)	12		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.018)|LUSC - Lung squamous cell carcinoma(193;0.116)		TCAACAGATTATATGCAAGAG	0.358000													20	39					0	0	0.000958276	0	0
PER3	8863	broad.mit.edu	37	1	7863183	7863183	+	Missense_Mutation	SNP	C	C	T	rs145870917		TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:7863183C>T	ENST00000377532.3	+	8	1173	c.949C>T	c.(949-951)Cgt>Tgt	p.R317C	PER3_ENST00000377541.1_Missense_Mutation_p.R316C|PER3_ENST00000361923.2_Missense_Mutation_p.R316C			P56645	PER3_HUMAN	period circadian clock 3	316	PAS 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	39	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		CCCTGAAGATCGTTCTCTGAT	0.428000													28	89					0	0	0.00127121	0	0
CHRNB4	1143	broad.mit.edu	37	15	78922068	78922068	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr15:78922068A>C	ENST00000261751.3	-	5	690	c.579T>G	c.(577-579)gaT>gaG	p.D193E	CHRNB4_ENST00000412074.2_Intron	NM_000750.3	NP_000741.1	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4 (neuronal)	193					regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(7)|kidney(1)|lung(13)|prostate(1)	22						GAGTAAAGTCATCCATGCTGG	0.562000													40	52					0	0	0.00148497	0	0
ANKRD20A5P	440482	broad.mit.edu	37	18	14184233	14184233	+	RNA	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr18:14184233G>A	ENST00000581935.1	+	0	922																				lung(3)	3						AATTGTCTAAGATTTTATTTT	0.269000													6	4					0	0	0.00116845	0	0
SERINC4	619189	broad.mit.edu	37	15	44087630	44087630	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr15:44087630G>A	ENST00000299969.6	-	9	1221	c.1076C>T	c.(1075-1077)tCc>tTc	p.S359F	SERINC4_ENST00000249714.3_Silent_p.F189F|SERF2_ENST00000594896.1_Intron|RP11-296A16.1_ENST00000417761.2_3'UTR|SERF2_ENST00000409646.1_Intron|SERF2_ENST00000409291.1_Intron|SERINC4_ENST00000319327.6_Silent_p.F433F			A6NH21	SERC4_HUMAN	serine incorporator 4	0					phospholipid biosynthetic process	integral to membrane				central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(2)|skin(1)	6		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		GBM - Glioblastoma multiforme(94;7.81e-07)		GTGAGGCAAGGAAGAAGACGA	0.502000													48	57					0	0	0.000781405	0	0
GRIA3	2892	broad.mit.edu	37	X	122599574	122599574	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chrX:122599574G>A	ENST00000264357.5	+	14	2666	c.2374G>A	c.(2374-2376)Gac>Aac	p.D792N	GRIA3_ENST00000371251.1_Missense_Mutation_p.D792N|GRIA3_ENST00000371256.5_Intron|GRIA3_ENST00000542149.1_Missense_Mutation_p.D792N	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	792					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	AGGCCTCTTGGACAAATTGAA	0.443000													40	4					0	0	0.000781405	0	0
FRY	10129	broad.mit.edu	37	13	32813472	32813472	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr13:32813472G>A	ENST00000380250.3	+	45	6998	c.6502G>A	c.(6502-6504)Gaa>Aaa	p.E2168K		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2168					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		GGATATAGCCGAAAGGATTGC	0.463000													41	34					0	0	0.00170553	0	0
VCAN	1462	broad.mit.edu	37	5	82837738	82837738	+	Silent	SNP	A	A	C			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr5:82837738A>C	ENST00000265077.3	+	8	9481	c.8916A>C	c.(8914-8916)acA>acC	p.T2972T	VCAN-AS1_ENST00000513899.1_RNA|VCAN_ENST00000343200.5_Silent_p.T1985T|VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000342785.4_Intron|VCAN_ENST00000512590.2_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2972	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AAGGTGCTACACAGTGGCCAC	0.483000													33	34					0	0	0.000814825	0	0
RPH3AL	9501	broad.mit.edu	37	17	177278	177278	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr17:177278C>T	ENST00000323434.8	-	3	654	c.57G>A	c.(55-57)cgG>cgA	p.R19R	RPH3AL_ENST00000536489.2_Silent_p.R19R|RPH3AL_ENST00000331302.7_Silent_p.R19R	NM_001190412.1	NP_001177341.1	Q9UNE2	RPH3L_HUMAN	rabphilin 3A-like (without C2 domains)	19					exocytosis|intracellular protein transport	transport vesicle membrane	cytoskeletal protein binding|Rab GTPase binding|zinc ion binding			NS(2)|breast(1)|kidney(1)|large_intestine(1)|skin(1)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.023)|all cancers(1;4.96e-06)|Epithelial(1;2.86e-05)|BRCA - Breast invasive adenocarcinoma(1;0.00453)|OV - Ovarian serous cystadenocarcinoma(1;0.0716)|LUAD - Lung adenocarcinoma(1115;0.102)|COAD - Colon adenocarcinoma(4;0.107)		GGGCAAGCTGCCGGTCATTGG	0.622000													17	33					0	0	0.00121646	0	0
EPHA8	2046	broad.mit.edu	37	1	22927916	22927916	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:22927916C>T	ENST00000166244.3	+	16	2925	c.2853C>T	c.(2851-2853)ttC>ttT	p.F951F		NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	951	SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GAGACCACTTCGCTGCGGGCG	0.701000													16	31					0	0	0.000958276	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664240	22664240	+	RNA	SNP	T	T	G			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr22:22664240T>G	ENST00000426066.1	+	0	763					NR_027293.1																						GATAAGCTGCTGATGAGCGGT	0.532000													4	55					0	0	0.00116845	0	0
MIER3	166968	broad.mit.edu	37	5	56219569	56219569	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr5:56219569G>A	ENST00000381226.3	-	12	1174	c.1159C>T	c.(1159-1161)Cct>Tct	p.P387S	SETD9_ENST00000541720.1_Intron|MIER3_ENST00000381199.3_Missense_Mutation_p.P382S|MIER3_ENST00000409421.1_Missense_Mutation_p.P319S|MIER3_ENST00000381213.3_Missense_Mutation_p.P381S			Q7Z3K6	MIER3_HUMAN	mesoderm induction early response 1, family member 3	382					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|liver(1)|lung(2)|urinary_tract(1)	19		Lung NSC(810;4.65e-05)|Prostate(74;0.0253)|Breast(144;0.0503)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;1.24e-37)		TGTTGATCAGGAATAGGCTCA	0.418000													67	37					0	0	0.000781405	0	0
DERA	51071	broad.mit.edu	37	12	16185524	16185524	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr12:16185524C>T	ENST00000428559.2	+	7	898	c.686C>T	c.(685-687)aCc>aTc	p.T229I	DERA_ENST00000532964.1_Missense_Mutation_p.T186I|DERA_ENST00000526530.1_Missense_Mutation_p.T141I|DERA_ENST00000532573.1_3'UTR	NM_015954.2	NP_057038.2	Q9Y315	DEOC_HUMAN	deoxyribose-phosphate aldolase (putative)	229					deoxyribonucleoside catabolic process|deoxyribonucleotide catabolic process	cytoplasm	deoxyribose-phosphate aldolase activity|protein binding			endometrium(1)|large_intestine(2)|lung(3)|skin(1)	7		Hepatocellular(102;0.121)				GTAAATGCCACCTTCCCGGTA	0.343000													5	4					0	0	0.000157383	0	0
CEP63	80254	broad.mit.edu	37	3	134250777	134250777	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr3:134250777G>A	ENST00000337090.3	+	4	486	c.313G>A	c.(313-315)Gaa>Aaa	p.E105K	CEP63_ENST00000332047.5_Missense_Mutation_p.E105K|CEP63_ENST00000383229.3_Missense_Mutation_p.E105K|CEP63_ENST00000513612.2_Missense_Mutation_p.E105K|CEP63_ENST00000354446.3_Missense_Mutation_p.E105K|CEP63_ENST00000504013.1_3'UTR|CEP63_ENST00000606977.1_Missense_Mutation_p.E105K			Q96MT8	CEP63_HUMAN	centrosomal protein 63kDa	105					cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding			kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						GAAACTACATGAAGAAGTGAG	0.358000													9	26					0	0	0.000274275	0	0
ZNF215	7762	broad.mit.edu	37	11	6977392	6977392	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr11:6977392T>C	ENST00000278319.5	+	7	1772	c.1184T>C	c.(1183-1185)aTt>aCt	p.I395T	ZNF215_ENST00000529903.1_Intron|ZNF215_ENST00000414517.2_Missense_Mutation_p.I395T	NM_013250.2	NP_037382.2	Q9UL58	ZN215_HUMAN	zinc finger protein 215	395					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(2)|skin(4)	32				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		TCATCCCTTATTCGACATCAG	0.383000													34	41					0	0	0.000814825	0	0
RPS6KA1	6195	broad.mit.edu	37	1	26873441	26873441	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:26873441C>T	ENST00000374168.2	+	3	346	c.192C>T	c.(190-192)ctC>ctT	p.L64L	RPS6KA1_ENST00000530003.1_Silent_p.L48L|RPS6KA1_ENST00000526792.1_5'UTR|RPS6KA1_ENST00000374162.2_Intron|RPS6KA1_ENST00000374166.4_Silent_p.L64L|RPS6KA1_ENST00000531382.1_Silent_p.L73L	NM_002953.3	NP_002944.2	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 1	64	Protein kinase 1.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		ATTTCGAGCTCCTCAAGGTTC	0.562000													29	20					0	0	0.00209593	0	0
CNTN5	53942	broad.mit.edu	37	11	100226921	100226921	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr11:100226921G>A	ENST00000524871.1	+	25	3563	c.3273G>A	c.(3271-3273)ttG>ttA	p.L1091L	CNTN5_ENST00000418526.2_Silent_p.L1017L|CNTN5_ENST00000279463.3_Silent_p.L1091L|CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000528682.1_Silent_p.L1091L	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	1091					cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CCTTGCTCTTGGCATTGATGA	0.423000													12	20					0	0	0.00185496	0	0
OR4K1	79544	broad.mit.edu	37	14	20403845	20403845	+	Missense_Mutation	SNP	C	C	T	rs146809169		TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr14:20403845C>T	ENST00000285600.4	+	1	79	c.20C>T	c.(19-21)tCg>tTg	p.S7L		NM_001004063.2	NP_001004063.2	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K, member 1	7					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		ACAAATGAATCGATGGTGTCT	0.348000													45	283					0	0	0.000781405	0	0
OR7E24	26648	broad.mit.edu	37	19	9362107	9362107	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:9362107G>A	ENST00000456448.1	+	1	502	c.388G>A	c.(388-390)Gac>Aac	p.D130N		NM_001079935.1	NP_001073404.1	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E, member 24	130					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)	16						ATGTATGGATGACATGCTCCT	0.488000													27	44					0	0	0.000878237	0	0
ALKBH2	121642	broad.mit.edu	37	12	109527892	109527892	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr12:109527892C>T	ENST00000429722.2	-	3	764	c.401G>A	c.(400-402)tGg>tAg	p.W134*	ALKBH2_ENST00000440112.2_Intron|ALKBH2_ENST00000343075.3_Nonsense_Mutation_p.W134*	NM_001145374.1	NP_001138846.1	Q6NS38	ALKB2_HUMAN	alkB, alkylation repair homolog 2 (E. coli)	134					DNA dealkylation involved in DNA repair|oxidative DNA demethylation	nucleoplasm	cytosine C-5 DNA demethylase activity|damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(3)|large_intestine(1)|lung(3)	8					Vitamin C(DB00126)	AACTGGGATCCAGGGCTTTGG	0.557000								Direct reversal of damage					22	42					0	0	0.00152264	0	0
OR4X1	390113	broad.mit.edu	37	11	48286316	48286316	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr11:48286316G>A	ENST00000320048.1	+	1	904	c.904G>A	c.(904-906)Gga>Aga	p.G302R		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						ATTTATTGGGGGAAAAGTAAT	0.398000													14	24					0	0	0.00185496	0	0
CCSER1	401145	broad.mit.edu	37	4	91645067	91645067	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr4:91645067T>G	ENST00000509176.1	+	7	2223	c.1935T>G	c.(1933-1935)agT>agG	p.S645R	CCSER1_ENST00000504150.1_3'UTR|CCSER1_ENST00000333691.8_Missense_Mutation_p.S645R|CCSER1_ENST00000432775.2_Missense_Mutation_p.S645R	NM_001145065.1	NP_001138537.1			coiled-coil serine-rich protein 1																		CCTTGCAGAGTGCAGACATGA	0.328000													4	0					0	0	0.00024832	0	0
AFF1	4299	broad.mit.edu	37	4	88048236	88048236	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr4:88048236C>T	ENST00000307808.6	+	14	3269	c.2849C>T	c.(2848-2850)tCt>tTt	p.S950F	AFF1_ENST00000395146.4_Missense_Mutation_p.S957F|AFF1_ENST00000544085.1_Missense_Mutation_p.S588F	NM_005935.2	NP_005926.1	P51825	AFF1_HUMAN	AF4/FMR2 family, member 1	950						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(2)	3		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		AATGGTAACTCTAAACCAGGG	0.388000													84	48					0	0	0.000781405	0	0
SNHG14	104472715	broad.mit.edu	37	15	25476051	25476051	+	RNA	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr15:25476051G>A	ENST00000453082.2	+	0	1523				SNORD115-33_ENST00000363723.1_RNA	NR_003343.1																						TGCTCAATAGGATTACGCTGA	0.517000													71	116					0	0	0.000781405	0	0
PLCH2	9651	broad.mit.edu	37	1	2410049	2410049	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:2410049G>A	ENST00000449969.1	+	2	339	c.178G>A	c.(178-180)Gag>Aag	p.E60K	PLCH2_ENST00000378483.2_3'UTR|PLCH2_ENST00000378486.3_Missense_Mutation_p.E87K|PLCH2_ENST00000288766.5_Missense_Mutation_p.E42K|PLCH2_ENST00000419816.2_Missense_Mutation_p.E87K|PLCH2_ENST00000378488.3_Missense_Mutation_p.E87K			O75038	PLCH2_HUMAN	phospholipase C, eta 2	87	Necessary for plasma membrane localization (By similarity).|PH.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		ACGCAAGAACGAGAAGGCCAA	0.652000													5	5					0	0	0.00198382	0	0
REV1	51455	broad.mit.edu	37	2	100058829	100058829	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:100058829C>T	ENST00000258428.3	-	5	681	c.453G>A	c.(451-453)gaG>gaA	p.E151E	REV1_ENST00000465835.1_5'UTR|REV1_ENST00000393445.3_Silent_p.E151E	NM_001037872.1|NM_016316.2	NP_001032961.1|NP_057400.1	Q9UBZ9	REV1_HUMAN	REV1, polymerase (DNA directed)	151					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(12)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GCAGAGGATCCTCAGGTCTGC	0.458000								Direct reversal of damage					35	38					0	0	0.000814825	0	0
CHD3	1107	broad.mit.edu	37	17	7796803	7796803	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr17:7796803T>C	ENST00000380358.4	+	5	887	c.886T>C	c.(886-888)Tcc>Ccc	p.S296P	CHD3_ENST00000358181.4_Missense_Mutation_p.S237P|CHD3_ENST00000330494.7_Missense_Mutation_p.S237P	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	237					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				CATAGCACCCTCCGGACCCCC	0.652000													5	2					0	0	0.00198382	0	0
NCKAP5	344148	broad.mit.edu	37	2	133542936	133542936	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:133542936G>A	ENST00000409261.1	-	14	1821	c.1448C>T	c.(1447-1449)tCc>tTc	p.S483F	NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Missense_Mutation_p.S483F|NCKAP5_ENST00000405974.3_Intron	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	483							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TGCTAAGGTGGAAGGGTCATC	0.527000													60	63					0	0	0.000781405	0	0
TRAJ12	28743	broad.mit.edu	37	14	23000893	23000893	+	RNA	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr14:23000893G>A	ENST00000390525.1	+	0	5																											ACTGTGGGATGGATAGCAGCT	0.453000													49	36					0	0	0.000781405	0	0
ADAM7	8756	broad.mit.edu	37	8	24350737	24350737	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr8:24350737G>A	ENST00000175238.6	+	16	1920	c.1837G>A	c.(1837-1839)Gga>Aga	p.G613R	ADAM7_ENST00000380789.1_Missense_Mutation_p.G613R|RP11-624C23.1_ENST00000519689.1_RNA|RP11-561E1.1_ENST00000519364.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|ADAM7_ENST00000520720.1_Missense_Mutation_p.G385R	NM_003817.3	NP_003808.2	Q9H2U9	ADAM7_HUMAN	ADAM metallopeptidase domain 7	613	Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(24)|ovary(1)|skin(15)	64		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		ATGTGGAGAGGGAATGGTAAG	0.368000													13	19					0	0	0.00136819	0	0
OR6A2	8590	broad.mit.edu	37	11	6816642	6816642	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr11:6816642C>T	ENST00000332601.3	-	1	486	c.298G>A	c.(298-300)Gag>Aag	p.E100K		NM_003696.2	NP_003687.2	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A, member 2	100					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(4)|pancreas(1)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	29		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		ATGCATCCCTCAAAGGAGATT	0.473000													25	39					0	0	0.000720815	0	0
ITIH4	3700	broad.mit.edu	37	3	52857968	52857968	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr3:52857968G>A	ENST00000266041.4	-	10	1320	c.1224C>T	c.(1222-1224)ggC>ggT	p.G408G	ITIH4_ENST00000406595.1_Silent_p.G408G|ITIH4_ENST00000485816.1_Silent_p.G408G|ITIH4_ENST00000346281.5_Silent_p.G408G|ITIH4_ENST00000434759.3_Silent_p.G320G|ITIH4-AS1_ENST00000478366.1_RNA	NM_002218.4	NP_002209.2	Q14624	ITIH4_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 4	408	VWFA.				acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		GGCTGTACCGGCCACTTACAG	0.582000													17	18					0	0	0.00121646	0	0
HNF4G	3174	broad.mit.edu	37	8	76465432	76465432	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr8:76465432G>A	ENST00000396423.2	+	5	739	c.615_splice	c.e5+1	p.Q205_splice	HNF4G_ENST00000354370.1_Splice_Site_p.Q168_splice	NM_004133.4	NP_004124.4	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	168					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	37	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			TGGATGATCAGGTACACATTT	0.318000													35	54					0	0	0.000814825	0	0
KRT25	147183	broad.mit.edu	37	17	38906748	38906748	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr17:38906748G>A	ENST00000312150.4	-	6	1119	c.1059C>T	c.(1057-1059)caC>caT	p.H353H		NM_181534.3	NP_853512.1	Q7Z3Z0	K1C25_HUMAN	keratin 25	353	Coil 2.|Rod.					cytoplasm|intermediate filament	structural molecule activity			endometrium(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(4)	16		Breast(137;0.00526)				TTCTGACCTGGTGCAGCTGCT	0.572000													93	112					0	0	0.000781405	0	0
PTPRD	5789	broad.mit.edu	37	9	8338947	8338947	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr9:8338947C>T	ENST00000381196.4	-	40	5897	c.5354G>A	c.(5353-5355)aGg>aAg	p.R1785K	PTPRD_ENST00000540109.1_Missense_Mutation_p.R1785K|PTPRD_ENST00000360074.4_Missense_Mutation_p.R1772K|PTPRD_ENST00000537002.1_Missense_Mutation_p.R1375K|PTPRD_ENST00000358503.5_Missense_Mutation_p.R1763K|PTPRD_ENST00000486161.1_Missense_Mutation_p.R1378K|PTPRD_ENST00000356435.5_Missense_Mutation_p.R1785K|PTPRD_ENST00000355233.5_Missense_Mutation_p.R1379K|PTPRD_ENST00000397617.3_Missense_Mutation_p.R1378K|PTPRD_ENST00000397606.3_Missense_Mutation_p.R1378K|PTPRD_ENST00000397611.3_Missense_Mutation_p.R1375K	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1785	Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CTTGAATTCCCTTAGGATATA	0.448000										TSP Lung(15;0.13)			57	10					0	0	0.000781405	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69049478	69049478	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:69049478G>C	ENST00000295381.3	+	10	1623	c.1204G>C	c.(1204-1206)Gac>Cac	p.D402H	ARHGAP25_ENST00000409030.3_Missense_Mutation_p.D395H|ARHGAP25_ENST00000467265.1_Missense_Mutation_p.D363H|ARHGAP25_ENST00000409202.3_Missense_Mutation_p.D403H|ARHGAP25_ENST00000479844.1_Missense_Mutation_p.D96H|ARHGAP25_ENST00000409220.1_Missense_Mutation_p.D396H	NM_001007231.2	NP_001007232.2	P42331	RHG25_HUMAN	Rho GTPase activating protein 25	402					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(20)|ovary(3)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	52						CTAGACAAGCGACTCTGATAC	0.507000													46	91					0	0	0.000781405	0	0
KIAA2022	340533	broad.mit.edu	37	X	73962468	73962468	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chrX:73962468G>T	ENST00000373468.1	-	3	2575	c.1924C>A	c.(1924-1926)Cca>Aca	p.P642T	KIAA2022_ENST00000055682.5_Missense_Mutation_p.P642T			Q5QGS0	K2022_HUMAN	KIAA2022	642					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						TCAATGGATGGGATTCTTTGA	0.403000													14	3					2.32078e-09	1.00027e-08	0.000308642	1	0
PKD1L2	114780	broad.mit.edu	37	16	81249940	81249940	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr16:81249940G>A	ENST00000599697.1	-	2	372	c.373C>T	c.(373-375)Cct>Tct	p.P125S	PKD1L2_ENST00000337114.4_RNA|PKD1L2_ENST00000525539.1_RNA			Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2	125	C-type lectin.				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						CAGGTGTCAGGGGCAGCGGCG	0.652000													13	31					0	0	0.000566183	0	0
PRPF40A	55660	broad.mit.edu	37	2	153520278	153520278	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:153520278C>T	ENST00000410080.1	-	19	2520	c.1979G>A	c.(1978-1980)gGa>gAa	p.G660E		NM_017892.3	NP_060362.3	O75400	PR40A_HUMAN	PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)	687	FF 4.				mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|prostate(1)|urinary_tract(1)	21						AACTACAAATCCTTTATCCTA	0.269000													23	39					0	0	0.00278032	0	0
ETFB	2109	broad.mit.edu	37	19	51856511	51856511	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:51856511C>T	ENST00000354232.4	-	2	2990	c.523G>A	c.(523-525)Gac>Aac	p.D175N	ETFB_ENST00000309244.4_Missense_Mutation_p.D84N|CTD-2616J11.9_ENST00000600974.1_RNA|CTD-2616J11.11_ENST00000600067.1_3'UTR	NM_001014763.1	NP_001014763.1	P38117	ETFB_HUMAN	electron-transfer-flavoprotein, beta polypeptide	84					respiratory electron transport chain|transport	mitochondrial matrix	electron carrier activity	p.D175Y(1)		kidney(2)|large_intestine(1)|lung(3)	6		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000226)|OV - Ovarian serous cystadenocarcinoma(262;0.00661)		ATACCTCGGTCTGCACCCATG	0.637000													34	47					0	0	0.00111076	0	0
ZFP69B	65243	broad.mit.edu	37	1	40929140	40929140	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:40929140G>A	ENST00000411995.2	+	6	1859	c.1484G>A	c.(1483-1485)aGa>aAa	p.R495K	ZFP69B_ENST00000484445.1_3'UTR|ZFP69B_ENST00000361584.3_Missense_Mutation_p.R393K	NM_023070.2	NP_075558.2			ZFP69 zinc finger protein B									p.R393I(1)									AAACATCAGAGAATTCATACT	0.373000													32	16					0	0	0.00178596	0	0
CELSR1	9620	broad.mit.edu	37	22	46761267	46761267	+	Silent	SNP	G	G	A	rs138188369	byFrequency	TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr22:46761267G>A	ENST00000262738.3	-	32	8414	c.8415C>T	c.(8413-8415)tcC>tcT	p.S2805S		NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	2805					central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TATCTGAGTCGGAATCGTGGC	0.637000													12	16					0	0	0.000308642	0	0
ALG1	56052	broad.mit.edu	37	16	5123177	5123177	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr16:5123177G>A	ENST00000262374.5	+	3	341	c.310G>A	c.(310-312)Gga>Aga	p.G104R	ALG1_ENST00000588623.1_5'UTR|ALG1_ENST00000544428.1_5'UTR	NM_019109.4	NP_061982.3	Q9BT22	ALG1_HUMAN	ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase	104					dolichol-linked oligosaccharide biosynthetic process|lipopolysaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	chitobiosyldiphosphodolichol beta-mannosyltransferase activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		Ovarian(90;0.0164)				TTTCCAGTACGGAGTCAAAGT	0.512000													20	37					0	0	0.00152264	0	0
NLGN1	22871	broad.mit.edu	37	3	173998987	173998987	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr3:173998987C>T	ENST00000457714.1	+	7	2795	c.2366C>T	c.(2365-2367)cCa>cTa	p.P789L	NLGN1_ENST00000401917.3_Missense_Mutation_p.P829L|NLGN1_ENST00000545397.1_Missense_Mutation_p.P789L|NLGN1_ENST00000361589.4_Missense_Mutation_p.P789L	NM_014932.2	NP_055747.1	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	806					calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(2)|lung(54)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	83	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			AACACTATACCAGGGATTCAG	0.483000													35	29					0	0	0.00283554	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994617	140994617	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chrX:140994617C>T	ENST00000285879.4	+	4	1713	c.1427C>T	c.(1426-1428)tCt>tTt	p.S476F	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	476							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TTTCCCCAGTCTCCTCTCCAG	0.468000										HNSCC(15;0.026)			101	11					0	0	0.000781405	0	0
DLGAP2	9228	broad.mit.edu	37	8	1581039	1581039	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr8:1581039C>T	ENST00000421627.2	+	5	1531	c.1397C>T	c.(1396-1398)tCc>tTc	p.S466F		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	545					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		GTGTGCGAGTCCGTCTTCAGT	0.582000													15	6					0	0	0.000566183	0	0
ZNF750	79755	broad.mit.edu	37	17	80788605	80788605	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr17:80788605C>T	ENST00000269394.3	-	3	2418	c.1585G>A	c.(1585-1587)Gaa>Aaa	p.E529K	TBCD_ENST00000539345.2_Intron|TBCD_ENST00000397466.2_Intron|TBCD_ENST00000355528.4_Intron|ZNF750_ENST00000572562.1_Missense_Mutation_p.E130K	NM_024702.2	NP_078978.2	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	529						intracellular	zinc ion binding	p.E529K(2)		NS(3)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	31	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TACGTGGGTTCGTGGGTGGCT	0.617000													38	37					0	0	0.00170553	0	0
FLVCR1	28982	broad.mit.edu	37	1	213032489	213032489	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:213032489A>C	ENST00000366971.4	+	1	893	c.695A>C	c.(694-696)aAa>aCa	p.K232T		NM_014053.3	NP_054772.1	Q9Y5Y0	FLVC1_HUMAN	feline leukemia virus subgroup C cellular receptor 1	232					cell death|cellular iron ion homeostasis|heme export|transmembrane transport	integral to plasma membrane	heme transporter activity|protein binding|receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(2)	12				OV - Ovarian serous cystadenocarcinoma(81;0.00733)|all cancers(67;0.013)|GBM - Glioblastoma multiforme(131;0.0845)|Epithelial(68;0.11)		TTTGGGCCCAAAGAGGTGTCC	0.562000													20	59					0	0	0.00229938	0	0
OR11A1	26531	broad.mit.edu	37	6	29394760	29394760	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr6:29394760G>A	ENST00000377149.1	-	5	1131	c.659C>T	c.(658-660)gCc>gTc	p.A220V	OR11A1_ENST00000377148.1_Missense_Mutation_p.A220V|OR11A1_ENST00000377147.2_Missense_Mutation_p.A220V|OR5V1_ENST00000377154.1_Intron			Q9GZK7	O11A1_HUMAN	olfactory receptor, family 11, subfamily A, member 1	220					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|large_intestine(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	19						CACAATTCTGGCATAAGATGT	0.522000													19	15					0	0	0.00074312	0	0
SPOCD1	90853	broad.mit.edu	37	1	32280643	32280643	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:32280643G>A	ENST00000360482.2	-	2	421	c.292C>T	c.(292-294)Cct>Tct	p.P98S	SPOCD1_ENST00000533231.1_Missense_Mutation_p.P98S|SPOCD1_ENST00000373648.2_Missense_Mutation_p.P98S|SPOCD1_ENST00000257100.3_Intron	NM_144569.4	NP_653170.3	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	98					transcription, DNA-dependent					NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(1)|lung(7)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	37		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		TGGAGCCCAGGAGCCAGCATC	0.627000													24	17					0	0	0.000586117	0	0
KCNH7	90134	broad.mit.edu	37	2	163292066	163292066	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:163292066G>A	ENST00000332142.5	-	8	1695	c.1596C>T	c.(1594-1596)ctC>ctT	p.L532L	KCNH7_ENST00000328032.4_Silent_p.L525L	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	532					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	GCACAAGACGGAGGAGTCGGG	0.443000													29	34					0	0	0.00178596	0	0
CENPM	79019	broad.mit.edu	37	22	42335114	42335114	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr22:42335114C>T	ENST00000402338.1	-	5	628	c.387G>A	c.(385-387)ctG>ctA	p.L129L	CENPM_ENST00000215980.5_Silent_p.L163L|CENPM_ENST00000407253.3_3'UTR|CENPM_ENST00000404067.1_3'UTR|CENPM_ENST00000472374.2_Silent_p.L41L			Q9NSP4	CENPM_HUMAN	centromere protein M	163					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus				kidney(1)|large_intestine(1)|prostate(1)	3						ACAGCAGGTTCAGAGCTGAGA	0.667000													16	19					0	0	0.000422831	0	0
TMEM41B	440026	broad.mit.edu	37	11	9310040	9310040	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr11:9310040T>C	ENST00000528080.1	-	4	749	c.411A>G	c.(409-411)atA>atG	p.I137M	TMEM41B_ENST00000527813.1_Missense_Mutation_p.I137M	NM_015012.3	NP_055827.1	Q5BJD5	TM41B_HUMAN	transmembrane protein 41B	137						integral to membrane				kidney(1)|large_intestine(2)|lung(1)|prostate(1)|urinary_tract(2)	7				all cancers(16;9.96e-08)|Epithelial(150;4.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0972)		ACCCTGAGAGTATACTGAGAA	0.294000													34	32					0	0	0.000953801	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45556242	45556242	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr18:45556242C>T	ENST00000588982.1	-	4	1750	c.1249G>A	c.(1249-1251)Gag>Aag	p.E417K	ZBTB7C_ENST00000586438.1_Missense_Mutation_p.E417K|ZBTB7C_ENST00000332053.2_Missense_Mutation_p.E417K|ZBTB7C_ENST00000590800.1_Missense_Mutation_p.E417K|ZBTB7C_ENST00000535628.2_Missense_Mutation_p.E417K			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	417						intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						TAGGGCCGCTCCCCTGTGTGC	0.592000													18	17					0	0	0.00152264	0	0
GSDMB	55876	broad.mit.edu	37	17	38062460	38062460	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr17:38062460G>A	ENST00000394175.2	-	5	949	c.726C>T	c.(724-726)gtC>gtT	p.V242V	GSDMB_ENST00000418519.1_Silent_p.V264V|GSDMB_ENST00000394179.1_Silent_p.V259V|GSDMB_ENST00000360317.3_Silent_p.V264V|GSDMB_ENST00000309481.7_Silent_p.V251V|GSDMB_ENST00000520542.1_Silent_p.V255V	NM_018530.2	NP_061000.2	Q8TAX9	GSDMB_HUMAN	gasdermin B	259						cytoplasm				breast(2)|endometrium(3)|large_intestine(6)|lung(6)|pancreas(1)|prostate(1)|stomach(2)	21						GGTCCTTGAGGACACTCTCCA	0.502000													35	50					0	0	0.000814825	0	0
SPEF2	79925	broad.mit.edu	37	5	35654808	35654808	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr5:35654808A>C	ENST00000440995.2	+	7	958	c.958A>C	c.(958-960)Ata>Cta	p.I320L	SPEF2_ENST00000356031.3_Missense_Mutation_p.I320L|SPEF2_ENST00000509059.1_Missense_Mutation_p.I320L|SPEF2_ENST00000282469.6_Missense_Mutation_p.I320L			Q9C093	SPEF2_HUMAN	sperm flagellar 2	320					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GGACCAGTTAATAGCCCACGA	0.378000													14	20					0	0	0.000566183	0	0
MROH2B	133558	broad.mit.edu	37	5	41000352	41000352	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr5:41000352C>T	ENST00000399564.4	-	39	4902	c.4452G>A	c.(4450-4452)agG>agA	p.R1484R	MROH2B_ENST00000506092.2_Silent_p.R1039R	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		TGTAGAAATCCCTGGCCCTTG	0.502000													23	31					0	0	0.000586117	0	0
NPAS4	266743	broad.mit.edu	37	11	66191075	66191075	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr11:66191075G>A	ENST00000311034.2	+	6	1011	c.835G>A	c.(835-837)Gag>Aag	p.E279K		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	279	PAC.				transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						TATTCAGGCAGAGATGGTGGT	0.517000													36	37					0	0	0.00128727	0	0
ESF1	51575	broad.mit.edu	37	20	13695681	13695681	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr20:13695681C>T	ENST00000202816.1	-	14	2503	c.2396G>A	c.(2395-2397)cGg>cAg	p.R799Q		NM_001276380.1|NM_016649.3	NP_001263309.1|NP_057733.2	Q9H501	ESF1_HUMAN	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)	799	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|skin(1)|stomach(1)	31						TTGTTCTTTCCGTTCTCTTTG	0.393000													47	93					0	0	0.000781405	0	0
SLC28A2	9153	broad.mit.edu	37	15	45562453	45562453	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr15:45562453G>A	ENST00000347644.3	+	15	1692	c.1627G>A	c.(1627-1629)Gga>Aga	p.G543R	CTD-2651B20.3_ENST00000561404.1_RNA|CTD-2651B20.3_ENST00000560344.1_RNA	NM_004212.3	NP_004203.2	O43868	S28A2_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 2	543					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding|nucleoside:sodium symporter activity|purine nucleoside transmembrane transporter activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(4)|skin(1)	26		all_cancers(109;8.53e-07)|all_epithelial(112;1.39e-05)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.77e-16)|GBM - Glioblastoma multiforme(94;2.71e-06)		TAGTTCCATAGGAATCACACT	0.433000													41	50					0	0	0.00285205	0	0
PKD1L2	114780	broad.mit.edu	37	16	81249941	81249941	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr16:81249941G>A	ENST00000599697.1	-	2	371	c.372C>T	c.(370-372)gcC>gcT	p.A124A	PKD1L2_ENST00000337114.4_RNA|PKD1L2_ENST00000525539.1_RNA			Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2	124	C-type lectin.				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						AGGTGTCAGGGGCAGCGGCGG	0.647000													13	31					0	0	0.000566183	0	0
FAT3	120114	broad.mit.edu	37	11	92615911	92615911	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr11:92615911G>A	ENST00000298047.6	+	23	12306	c.12289G>A	c.(12289-12291)Gag>Aag	p.E4097K	FAT3_ENST00000525166.1_Missense_Mutation_p.E3947K|FAT3_ENST00000533797.1_Missense_Mutation_p.E432K|FAT3_ENST00000409404.2_Missense_Mutation_p.E4097K			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4097					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CAGGTGTGAGGAGGACATCAA	0.572000										TCGA Ovarian(4;0.039)			82	116					0	0	0.000781405	0	0
TTN	7273	broad.mit.edu	37	2	179477898	179477898	+	Silent	SNP	C	C	T	rs7355450		TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:179477898C>T	ENST00000589042.1	-	264	49862	c.49638G>A	c.(49636-49638)aaG>aaA	p.K16546K	TTN_ENST00000342175.6_Silent_p.K7673K|TTN_ENST00000460472.2_Silent_p.K7481K|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Silent_p.K7606K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342992.6_Silent_p.K13978K|TTN_ENST00000591111.1_Silent_p.K14905K|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	14905	Fibronectin type-III 20.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTATGGGATCCTTTATTAAGA	0.333000													22	27					0	0	0.00152264	0	0
PRPF40B	25766	broad.mit.edu	37	12	50036041	50036041	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr12:50036041G>A	ENST00000261897.1	+	19	2354	c.1803G>A	c.(1801-1803)cgG>cgA	p.R601R	PRPF40B_ENST00000548825.2_Silent_p.R636R|PRPF40B_ENST00000380281.1_Silent_p.R614R|FMNL3_ENST00000335154.5_3'UTR			Q6NWY9	PR40B_HUMAN	PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)	614					mRNA processing|RNA splicing	nuclear speck				breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34						CAGAGGCACGGGAGAGGGAGC	0.627000													25	55					0	0	0.000586117	0	0
DNAH5	1767	broad.mit.edu	37	5	13769624	13769624	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr5:13769624C>T	ENST00000265104.4	-	57	9810	c.9706G>A	c.(9706-9708)Gat>Aat	p.D3236N	DNAH5_ENST00000504001.3_5'UTR	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3236	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TCGGCTTTATCGTTGGCCACT	0.418000									Kartagener syndrome				34	52					0	0	0.00111076	0	0
CUBN	8029	broad.mit.edu	37	10	16967390	16967390	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr10:16967390A>C	ENST00000377833.4	-	43	6561	c.6496T>G	c.(6496-6498)Ttg>Gtg	p.L2166V		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	2166	CUB 15.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GGGGGTCCCAAGGGTGGAGAA	0.388000													25	3					0	0	0.000720815	0	0
TNS4	84951	broad.mit.edu	37	17	38635929	38635929	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr17:38635929C>T	ENST00000254051.6	-	10	2065	c.1907G>A	c.(1906-1908)aGg>aAg	p.R636K		NM_032865.5	NP_116254.4	Q8IZW8	TENS4_HUMAN	tensin 4	636	Phosphatase tensin-type.				apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	30		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			CCCTTACTTCCTCTGGACATC	0.587000													19	34					0	0	0.00188189	0	0
CCDC85B	11007	broad.mit.edu	37	11	65658858	65658858	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr11:65658858G>T	ENST00000312579.2	+	1	984	c.604G>T	c.(604-606)Gat>Tat	p.D202Y		NM_006848.2	NP_006839.2	Q15834	CC85B_HUMAN	coiled-coil domain containing 85B	202					cell differentiation|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	protein binding								READ - Rectum adenocarcinoma(159;0.166)		TTCCCCCGATGATTGAAGGCA	0.711000													4	7					3.59834e-05	0.000153801	0.00116845	1	0
HNRNPL	3191	broad.mit.edu	37	19	39330868	39330868	+	Silent	SNP	T	T	G			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:39330868T>G	ENST00000221419.5	-	8	1467	c.1101A>C	c.(1099-1101)ccA>ccC	p.P367P	HNRNPL_ENST00000600873.1_Silent_p.P234P	NM_001533.2	NP_001524.2	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	367	Pro-rich.				nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding	p.P367P(1)|p.P234P(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	30	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			GGGGAGGGGGTGGGGGGTGCC	0.642000													3	9					0	0	0.000157383	0	0
AHNAK	79026	broad.mit.edu	37	11	62300587	62300587	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr11:62300587C>T	ENST00000378024.4	-	5	1576	c.1302G>A	c.(1300-1302)atG>atA	p.M434I	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	434					nervous system development	nucleus	protein binding	p.M434I(1)		NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TGGGGACTTTCATCTTGGGCA	0.542000													30	30					0	0	0.00209593	0	0
CT47B1	643311	broad.mit.edu	37	X	120009363	120009363	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chrX:120009363G>A	ENST00000371311.3	-	1	416	c.162C>T	c.(160-162)gtC>gtT	p.V54V		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	54										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						CGGGCCCTGCGACTCCGACCA	0.736000													30	5					0	0	0.00209593	0	0
CD109	135228	broad.mit.edu	37	6	74493477	74493477	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr6:74493477C>T	ENST00000437994.2	+	19	2584	c.2153C>T	c.(2152-2154)aCt>aTt	p.T718I	CD109_ENST00000422508.2_Missense_Mutation_p.T641I|CD109_ENST00000287097.5_Missense_Mutation_p.T718I	NM_001159587.1|NM_133493.3	NP_001153059.1|NP_598000.2	Q6YHK3	CD109_HUMAN	CD109 molecule	718						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GATTCTATCACTTCTTGGGTG	0.368000													30	15					0	0	0.00127121	0	0
ELFN2	114794	broad.mit.edu	37	22	37769437	37769437	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr22:37769437G>A	ENST00000402918.1	-	3	2923	c.2138C>T	c.(2137-2139)cCc>cTc	p.P713L	RP1-63G5.5_ENST00000430883.1_RNA|ELFN2_ENST00000349653.3_Missense_Mutation_p.P713L	NM_052906.3	NP_443138.2	Q5R3F8	LRFN6_HUMAN	extracellular leucine-rich repeat and fibronectin type III domain containing 2	713						cell surface|integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	35	Melanoma(58;0.0574)					GTACAGGGCGGGAAAGCTGTG	0.711000													6	7					0	0	0.00116845	0	0
SLC6A19	340024	broad.mit.edu	37	5	1201811	1201811	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr5:1201811C>T	ENST00000304460.10	+	1	102	c.46C>T	c.(46-48)Ccg>Tcg	p.P16S		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	16					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CGCCCGGATCCCGTCCCTGGC	0.677000													7	9					0	0	0.000157383	0	0
PPA1	5464	broad.mit.edu	37	10	71990114	71990114	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr10:71990114G>A	ENST00000373232.2	-	2	205	c.106C>T	c.(106-108)Cca>Tca	p.P36S	PPA1_ENST00000460755.1_5'UTR|PPA1_ENST00000373230.4_Missense_Mutation_p.P36S	NM_021129.3	NP_066952.1	Q15181	IPYR_HUMAN	pyrophosphatase (inorganic) 1	36					diphosphate metabolic process|tRNA aminoacylation for protein translation	cytosol	inorganic diphosphatase activity|magnesium ion binding			breast(2)|endometrium(1)|large_intestine(2)|lung(3)|skin(2)	10						GCATAAATTGGAATATCATGA	0.299000													23	2					0	0	0.000878237	0	0
TRPS1	7227	broad.mit.edu	37	8	116616406	116616406	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr8:116616406G>A	ENST00000395715.3	-	4	2367	c.1790C>T	c.(1789-1791)cCg>cTg	p.P597L	TRPS1_ENST00000519076.1_Intron|TRPS1_ENST00000220888.5_Missense_Mutation_p.P584L|TRPS1_ENST00000520276.1_Missense_Mutation_p.P588L|TRPS1_ENST00000519674.1_Missense_Mutation_p.P584L	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	584					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P584L(1)		autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			ACAAGCAAACGGATAAGTAAT	0.468000									Langer-Giedion syndrome				20	66					0	0	0.00152264	0	0
RBL2	5934	broad.mit.edu	37	16	53515595	53515595	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr16:53515595C>A	ENST00000262133.6	+	21	3234	c.3097C>A	c.(3097-3099)Cca>Aca	p.P1033T	RBL2_ENST00000379935.4_3'UTR|RBL2_ENST00000544545.1_Intron	NM_005611.3	NP_005602.3	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	1033					cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						GGATGCTCCTCCACTCTCTCC	0.333000													23	219					3.01185e-09	1.29451e-08	0.000586117	1	0
KGFLP2	654466	broad.mit.edu	37	9	41963939	41963939	+	RNA	SNP	A	A	G			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr9:41963939A>G	ENST00000454645.1	-	0	656					NR_003670.1																						GATTTCCATGATATCTGCAAG	0.408000													6	37					0	0	0.000157383	0	0
MKL2	57496	broad.mit.edu	37	16	14341258	14341258	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr16:14341258C>T	ENST00000571589.1	+	12	2313	c.2141C>T	c.(2140-2142)cCc>cTc	p.P714L	MKL2_ENST00000574045.1_Intron|MKL2_ENST00000341243.5_Missense_Mutation_p.P703L|MKL2_ENST00000318282.5_Intron	NM_014048.3	NP_054767.3	Q9ULH7	MKL2_HUMAN	MKL/myocardin-like 2	703	Gln-rich.				cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(6)|liver(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GTTGCTCAGCCCCAGGCTTTA	0.592000													23	14					0	0	0.00229938	0	0
HELB	92797	broad.mit.edu	37	12	66725086	66725086	+	Silent	SNP	T	T	C			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr12:66725086T>C	ENST00000247815.4	+	12	2882	c.2823T>C	c.(2821-2823)ttT>ttC	p.F941F		NM_033647.3	NP_387467.2	Q8NG08	HELB_HUMAN	helicase (DNA) B	941					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	40			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		AAAACAGTTTTCCTAGAAAAA	0.517000													30	19					0	0	0.00209593	0	0
LRRC6	23639	broad.mit.edu	37	8	133669119	133669119	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr8:133669119C>T	ENST00000519595.1	-	3	311	c.213G>A	c.(211-213)ttG>ttA	p.L71L	LRRC6_ENST00000520446.1_5'UTR|LRRC6_ENST00000518642.1_Silent_p.L71L|LRRC6_ENST00000250173.1_Silent_p.L71L			Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	71						cytoplasm				breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|urinary_tract(2)	34	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			AAGCTAAATTCAAATATTCAA	0.229000													6	31					0	0	0.000157383	0	0
PTGS1	5742	broad.mit.edu	37	9	125146022	125146022	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr9:125146022C>T	ENST00000362012.2	+	8	1002	c.997C>T	c.(997-999)Ctc>Ttc	p.L333F	PTGS1_ENST00000373698.5_Missense_Mutation_p.L224F|PTGS1_ENST00000223423.4_Missense_Mutation_p.L333F|PTGS1_ENST00000540753.1_Missense_Mutation_p.L308F	NM_000962.2|NM_001271164.1|NM_080591.1	NP_000953.2|NP_001258093.1|NP_542158.1	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	333					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			large_intestine(3)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	8					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	GACGACCCGCCTCATCCTCAT	0.612000													17	23					0	0	0.00121646	0	0
C5orf24	134553	broad.mit.edu	37	5	134190754	134190754	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr5:134190754G>A	ENST00000394976.3	+	2	392	c.164G>A	c.(163-165)aGg>aAg	p.R55K	C5orf24_ENST00000338051.4_Missense_Mutation_p.R55K|C5orf24_ENST00000435259.2_Missense_Mutation_p.R55K|C5orf24_ENST00000504727.1_Missense_Mutation_p.R55K	NM_001135586.1	NP_001129058.1	Q7Z6I8	CE024_HUMAN	chromosome 5 open reading frame 24	55										breast(2)|endometrium(2)|lung(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTTTGTCAGAGGCAAGACCCA	0.403000													39	88					0	0	0.00170553	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117424487	117424487	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr7:117424487G>A	ENST00000160373.3	-	5	2181	c.2090C>T	c.(2089-2091)cCt>cTt	p.P697L		NM_033427.2	NP_219499.1	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	697										breast(3)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(36)|ovary(4)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		CATTAGCAAAGGGGTTAGGGA	0.507000													90	5					0	0	0.000781405	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				68	4					0	0	0.000781405	0	0
CEACAM21	90273	broad.mit.edu	37	19	42085674	42085674	+	Silent	SNP	A	A	G			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:42085674A>G	ENST00000407170.2	+	4	822	c.9A>G	c.(7-9)ccA>ccG	p.P3P	CEACAM21_ENST00000187608.9_Intron|CEACAM21_ENST00000401445.2_Intron|CEACAM21_ENST00000482870.2_Intron			Q3KPI0	CEA21_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 21	0						integral to membrane				endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|urinary_tract(1)	13						GCATGGCCCCAAGACACTTTC	0.512000													18	24					0	0	0.00121646	0	0
EIF5B	9669	broad.mit.edu	37	2	99988138	99988138	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:99988138G>A	ENST00000289371.5	+	9	1699	c.1497G>A	c.(1495-1497)gaG>gaA	p.E499E		NM_015904.3	NP_056988.3	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	499					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						AAGATACTGAGGATGCTGGAT	0.338000													16	22					0	0	0.00152264	0	0
ZIC2	7546	broad.mit.edu	37	13	100635129	100635129	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr13:100635129A>C	ENST00000376335.3	+	1	1104	c.811A>C	c.(811-813)Aag>Cag	p.K271Q		NM_007129.3	NP_009060.2	O95409	ZIC2_HUMAN	Zic family member 2	271					brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(2)|liver(2)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CAATCCCAAGAAGAGCTGCAA	0.582000													20	61					0	0	0.00278032	0	0
OR1D2	4991	broad.mit.edu	37	17	2995982	2995982	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr17:2995982G>A	ENST00000331459.1	-	1	308	c.309C>T	c.(307-309)ttC>ttT	p.F103F		NM_002548.2	NP_002539.2	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D, member 2	103					cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(2)|lung(10)|ovary(1)	15						AGGAGACCAGGAAGTAGAGCT	0.542000													80	77					0	0	0.000781405	0	0
SCG2	7857	broad.mit.edu	37	2	224462334	224462334	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:224462334G>A	ENST00000305409.2	-	2	1899	c.1667C>T	c.(1666-1668)tCt>tTt	p.S556F		NM_003469.4	NP_003460.2	P13521	SCG2_HUMAN	secretogranin II	556					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			NS(1)|breast(1)|endometrium(1)|kidney(6)|large_intestine(10)|liver(1)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	44		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		AGTCTCCTGAGAGCTGCCTTG	0.517000													29	34					0	0	0.00127121	0	0
SLC30A5	64924	broad.mit.edu	37	5	68412402	68412402	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr5:68412402G>A	ENST00000396591.3	+	10	1864	c.1254G>A	c.(1252-1254)caG>caA	p.Q418Q	CTC-498J12.3_ENST00000504129.1_RNA	NM_022902.4	NP_075053.2	Q8TAD4	ZNT5_HUMAN	solute carrier family 30 (zinc transporter), member 5	418					cellular zinc ion homeostasis|cobalt ion transport|regulation of proton transport|response to zinc ion	apical plasma membrane|Golgi apparatus|integral to plasma membrane|membrane fraction|secretory granule membrane	zinc ion binding|zinc ion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Lung NSC(167;0.000986)|Prostate(74;0.00809)|Colorectal(97;0.0508)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		ACTCTAGGCAGATCTTTTACT	0.323000													40	13					0	0	0.00222228	0	0
WDR62	284403	broad.mit.edu	37	19	36593925	36593925	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:36593925C>T	ENST00000401500.2	+	28	3446	c.3411C>T	c.(3409-3411)ggC>ggT	p.G1137G	WDR62_ENST00000270301.7_Silent_p.G1132G	NM_001083961.1|NM_173636.4	NP_001077430.1|NP_775907.4	O43379	WDR62_HUMAN	WD repeat domain 62	1132					cerebral cortex development	nucleus				cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(15)|prostate(4)|stomach(2)|urinary_tract(3)	43	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TGGACCGAGGCGGAAGCCAGC	0.647000													18	22					0	0	0.00074312	0	0
MYL9	10398	broad.mit.edu	37	20	35177484	35177484	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr20:35177484C>T	ENST00000279022.2	+	4	455	c.351C>T	c.(349-351)ttC>ttT	p.F117F	MYL9_ENST00000346786.2_Silent_p.F63F|RP5-977B1.7_ENST00000439595.1_RNA|RP5-977B1.7_ENST00000425233.1_RNA	NM_006097.4	NP_006088.2	P24844	MYL9_HUMAN	myosin, light chain 9, regulatory	117	EF-hand 2.				axon guidance|muscle contraction|regulation of muscle contraction	cytosol|muscle myosin complex	calcium ion binding|structural constituent of muscle			endometrium(2)|kidney(1)|large_intestine(3)|lung(2)	8	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CCGCAGGTTTCATCCATGAGG	0.602000													26	20					0	0	0.00178596	0	0
KCNQ3	3786	broad.mit.edu	37	8	133141683	133141683	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr8:133141683A>T	ENST00000388996.4	-	15	2865	c.2445T>A	c.(2443-2445)gaT>gaA	p.D815E	KCNQ3_ENST00000519445.1_Missense_Mutation_p.D803E|KCNQ3_ENST00000521134.1_Missense_Mutation_p.D695E	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	815					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			CGAACACATAATCATCTCTGT	0.607000													18	29					0	0	0.00121646	0	0
GRK7	131890	broad.mit.edu	37	3	141497499	141497499	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr3:141497499T>G	ENST00000264952.2	+	1	510	c.373T>G	c.(373-375)Ttc>Gtc	p.F125V		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	125	RGS.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						CCCGCAACCCTTCCTCAGCCA	0.667000													14	12					0	0	0.00185496	0	0
MME	4311	broad.mit.edu	37	3	154834527	154834527	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr3:154834527G>A	ENST00000460393.1	+	6	634	c.514G>A	c.(514-516)Gaa>Aaa	p.E172K	MME_ENST00000462745.1_Missense_Mutation_p.E172K|MME_ENST00000492661.1_Missense_Mutation_p.E172K|MME_ENST00000493237.1_Missense_Mutation_p.E172K|MME_ENST00000360490.2_Missense_Mutation_p.E172K	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	172					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	AGTAGCAACAGAAAACTGGGA	0.343000													12	28					0	0	0.00185496	0	0
VSIG8	391123	broad.mit.edu	37	1	159827671	159827671	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:159827671G>A	ENST00000368100.1	-	4	651	c.516C>T	c.(514-516)ggC>ggT	p.G172G		NM_001013661.1	NP_001013683.1	Q5VU13	VSIG8_HUMAN	V-set and immunoglobulin domain containing 8	172	Ig-like V-type 2.					integral to membrane				central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	8	all_hematologic(112;0.0597)					GGGGCTGGGAGCCCCCACTGG	0.587000													41	14					0	0	0.00285205	0	0
KRTAP21-1	337977	broad.mit.edu	37	21	32127550	32127550	+	Silent	SNP	A	A	G			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr21:32127550A>G	ENST00000335093.3	-	1	196	c.147T>C	c.(145-147)ggT>ggC	p.G49G		NM_181619.1	NP_853650.1	Q3LI58	KR211_HUMAN	keratin associated protein 21-1	49						intermediate filament				breast(1)|endometrium(1)|lung(4)|urinary_tract(1)	7						cagttccataaccacagccat	0.527000													54	78					0	0	0.000781405	0	0
OBSCN	84033	broad.mit.edu	37	1	228476516	228476516	+	Silent	SNP	G	G	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:228476516G>T	ENST00000570156.2	+	43	11627	c.11553G>T	c.(11551-11553)ctG>ctT	p.L3851L	OBSCN_ENST00000284548.11_Silent_p.L3422L|OBSCN_ENST00000359599.6_Silent_p.L2269L|OBSCN_ENST00000366709.4_Silent_p.L541L|OBSCN_ENST00000422127.1_Silent_p.L3422L|OBSCN_ENST00000366707.4_Silent_p.L541L	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2888	Ig-like 39.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TCTGTGGCCTGGCTGTGGCAG	0.627000													24	39					3.7963e-18	1.65472e-17	0.00047179	1	0
HAO2	51179	broad.mit.edu	37	1	119923791	119923791	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:119923791G>A	ENST00000361035.4	+	3	405	c.122G>A	c.(121-123)gGa>gAa	p.G41E	HAO2_ENST00000325945.3_Missense_Mutation_p.G28E	NM_001005783.1	NP_001005783.1	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2 (long chain)	28	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		ATTGAAGGTGGAGCAGATGAC	0.483000													36	75					0	0	0.000692331	0	0
TESPA1	9840	broad.mit.edu	37	12	55356885	55356885	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr12:55356885G>A	ENST00000524622.1	-	7	1044	c.383C>T	c.(382-384)tCc>tTc	p.S128F	TESPA1_ENST00000316577.8_Missense_Mutation_p.S266F|TESPA1_ENST00000532804.1_Missense_Mutation_p.S128F|TESPA1_ENST00000449076.1_Missense_Mutation_p.S266F|TESPA1_ENST00000531122.1_Missense_Mutation_p.S128F	NM_001261844.1|NM_014796.2	NP_001248773.1|NP_055611.1	A2RU30	K0748_HUMAN	thymocyte expressed, positive selection associated 1	266																	AATCCTGATGGATGGCACATC	0.527000													11	19					0	0	0.00185496	0	0
SETBP1	26040	broad.mit.edu	37	18	42530952	42530952	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr18:42530952C>T	ENST00000282030.5	+	4	1943	c.1647C>T	c.(1645-1647)gcC>gcT	p.A549A		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	549						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CAGTTATGGCCACCTCTGATA	0.507000									Schinzel-Giedion syndrome				47	95					0	0	0.000781405	0	0
LRRC1	55227	broad.mit.edu	37	6	53706942	53706942	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr6:53706942G>A	ENST00000370888.1	+	2	471	c.194G>A	c.(193-195)gGa>gAa	p.G65E	LRRC1_ENST00000370882.1_Missense_Mutation_p.G65E	NM_018214.4	NP_060684.4	Q9BTT6	LRRC1_HUMAN	leucine rich repeat containing 1	65						cytoplasm|membrane				cervix(1)|endometrium(3)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)		CGAAAGCTTGGACTTAGTGAT	0.368000													14	48					0	0	0.00074312	0	0
GNL3	26354	broad.mit.edu	37	3	52727560	52727560	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr3:52727560G>A	ENST00000394799.2	+	12	1498	c.1288_splice	c.e12+1	p.A430_splice	GNL3_ENST00000418458.1_Splice_Site_p.A442_splice	NM_206825.1	NP_996561.1	Q9BVP2	GNL3_HUMAN	guanine nucleotide binding protein-like 3 (nucleolar)	442	Intermediate (By similarity).				regulation of cell proliferation	nucleolus	GTP binding|protein binding			breast(4)|endometrium(3)|large_intestine(3)|lung(2)	12				BRCA - Breast invasive adenocarcinoma(193;6.75e-05)|Kidney(197;0.000611)|KIRC - Kidney renal clear cell carcinoma(197;0.000773)|OV - Ovarian serous cystadenocarcinoma(275;0.048)		GAGCATAAGAGGTGAGAATTG	0.468000													24	67					0	0	0.00278032	0	0
RASA4CP	401331	broad.mit.edu	37	7	44069176	44069176	+	RNA	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr7:44069176G>A	ENST00000446874.1	-	0	677																											CTTTGCCAGGGCTCGTGGGCA	0.697000													3	1					0	0	6.4e-05	0	0
CADM4	199731	broad.mit.edu	37	19	44131417	44131417	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:44131417T>A	ENST00000222374.2	-	3	313	c.265A>T	c.(265-267)Atc>Ttc	p.I89F		NM_145296.1	NP_660339.1	Q8NFZ8	CADM4_HUMAN	cell adhesion molecule 4	89	Ig-like V-type.				cell adhesion	integral to membrane				endometrium(2)|large_intestine(3)|lung(4)|prostate(1)|skin(2)	12		Prostate(69;0.0199)				GAGAGCCGGATCCGCACCCGG	0.602000													17	43					0	0	0.00121646	0	0
MECOM	2122	broad.mit.edu	37	3	168834174	168834174	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr3:168834174G>A	ENST00000464456.1	-	7	2122	c.922C>T	c.(922-924)Cct>Tct	p.P308S	MECOM_ENST00000468789.1_Missense_Mutation_p.P308S|MECOM_ENST00000433243.2_Missense_Mutation_p.P309S|MECOM_ENST00000264674.3_Missense_Mutation_p.P373S|MECOM_ENST00000494292.1_Missense_Mutation_p.P496S|MECOM_ENST00000392736.3_Missense_Mutation_p.P308S|MECOM_ENST00000472280.1_Missense_Mutation_p.P309S|MECOM_ENST00000460814.1_Missense_Mutation_p.P308S	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						AAGCCGGAAGGAAACAGACCA	0.478000													13	50					0	0	0.00185496	0	0
NFIB	4781	broad.mit.edu	37	9	14120611	14120611	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr9:14120611C>T	ENST00000380959.3	-	8	1546	c.1073G>A	c.(1072-1074)cGa>cAa	p.R358Q	NFIB_ENST00000543693.1_Missense_Mutation_p.R106Q|NFIB_ENST00000380953.1_Missense_Mutation_p.R358Q|NFIB_ENST00000397575.3_Missense_Mutation_p.R358Q|NFIB_ENST00000397579.2_Missense_Mutation_p.R358Q|NFIB_ENST00000380924.1_Missense_Mutation_p.R106Q|NFIB_ENST00000380934.4_Missense_Mutation_p.R384Q|NFIB_ENST00000397581.2_Missense_Mutation_p.R358Q	NM_005596.3	NP_005587.2	O00712	NFIB_HUMAN	nuclear factor I/B	358					anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity			central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		AGGTGGAGTTCGAGTTGAGAT	0.458000			T	"""MYB, HGMA2"""	"""adenoid cystic carcinoma, lipoma"""								10	2					0	0	0.000442599	0	0
CMTM5	116173	broad.mit.edu	37	14	23847927	23847927	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr14:23847927C>T	ENST00000339180.4	+	3	545	c.329C>T	c.(328-330)tCc>tTc	p.S110F	CMTM5_ENST00000382809.2_Intron|CMTM5_ENST00000397227.3_Intron|CMTM5_ENST00000359320.3_Intron|CMTM5_ENST00000555731.1_Intron|CMTM5_ENST00000342473.4_Intron			Q96DZ9	CKLF5_HUMAN	CKLF-like MARVEL transmembrane domain containing 5	110	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity			endometrium(1)|large_intestine(1)|lung(4)|prostate(1)|stomach(1)	8	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.0064)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0382)		GATCTACTCTCCCACTCAGCA	0.627000													8	22					0	0	0.000157383	0	0
ZNF600	162966	broad.mit.edu	37	19	53269225	53269225	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:53269225G>A	ENST00000338230.3	-	3	2051	c.1784C>T	c.(1783-1785)tCa>tTa	p.S595L		NM_198457.2	NP_940859.2	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	595					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(9)|liver(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)		TGCCAGGTATGAATTACGCAC	0.408000													72	98					0	0	0.000781405	0	0
ZNF91	7644	broad.mit.edu	37	19	23542295	23542295	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:23542295G>A	ENST00000300619.7	-	4	3691	c.3486C>T	c.(3484-3486)atC>atT	p.I1162I	ZNF91_ENST00000397082.2_Silent_p.I1130I|ZNF91_ENST00000599743.1_Intron	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	1162						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				aaagtagtgggattacaggtg	0.443000													14	20					0	0	0.00185496	0	0
TRAF5	7188	broad.mit.edu	37	1	211545968	211545968	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:211545968C>T	ENST00000261464.5	+	11	1652	c.1598C>T	c.(1597-1599)gCc>gTc	p.A533V	TRAF5_ENST00000427925.2_Missense_Mutation_p.A427V|TRAF5_ENST00000336184.2_Missense_Mutation_p.A533V|TRAF5_ENST00000367004.3_Missense_Mutation_p.A533V	NM_001033910.2	NP_001029082.1	O00463	TRAF5_HUMAN	TNF receptor-associated factor 5	533	MATH.				apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis	CD40 receptor complex|centrosome|internal side of plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				OV - Ovarian serous cystadenocarcinoma(81;0.00946)|all cancers(67;0.0808)|Epithelial(68;0.144)		TTGGAGAATGCCAAGAACGCC	0.473000													26	82					0	0	0.00047179	0	0
MUC16	94025	broad.mit.edu	37	19	9082453	9082453	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:9082453G>T	ENST00000397910.4	-	1	9565	c.9362C>A	c.(9361-9363)cCa>cAa	p.P3121Q		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3122	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAAGGATGTTGGGGTCTCAGA	0.498000													7	251					0.00198382	0.00836347	0.00198382	1	0
PAK7	57144	broad.mit.edu	37	20	9525015	9525015	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr20:9525015C>T	ENST00000378429.3	-	9	2416		c.e9+1		PAK7_ENST00000353224.5_Splice_Site|PAK7_ENST00000378423.1_Splice_Site	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7								ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			GACCCCCTTACCTCTGTCCCA	0.542000													67	69					0	0	0.000781405	0	0
NPR1	4881	broad.mit.edu	37	1	153665653	153665653	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:153665653C>T	ENST00000368680.3	+	21	3575	c.3103C>T	c.(3103-3105)Cga>Tga	p.R1035*		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	1035					body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	GCTGGAGCTTCGAGGGGATGT	0.562000													32	76					0	0	0.000692331	0	0
SRGAP2	23380	broad.mit.edu	37	1	206619608	206619608	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:206619608C>T	ENST00000414007.1	+	14	1642	c.1642C>T	c.(1642-1644)Cct>Tct	p.P548S	SRGAP2_ENST00000419187.2_5'UTR|SRGAP2_ENST00000471256.1_3'UTR			O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	688	Rho-GAP.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			NS(1)|breast(1)|kidney(1)|lung(1)	4	Breast(84;0.137)					GCTGGAGGGCCCTGTCTACAG	0.587000													90	84					0	0	0.000781405	0	0
ISLR2	57611	broad.mit.edu	37	15	74426504	74426504	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr15:74426504A>G	ENST00000361742.3	+	4	2178	c.1409A>G	c.(1408-1410)aAc>aGc	p.N470S	ISLR2_ENST00000453268.2_Missense_Mutation_p.N470S|ISLR2_ENST00000445793.1_Missense_Mutation_p.N470S|ISLR2_ENST00000419208.1_Missense_Mutation_p.N470S|ISLR2_ENST00000435464.1_Missense_Mutation_p.N470S|ISLR2_ENST00000565540.1_Missense_Mutation_p.N470S|ISLR2_ENST00000565159.1_Missense_Mutation_p.N470S|ISLR2_ENST00000561975.1_Intron	NM_001130136.1|NM_020851.2	NP_001123608.1|NP_065902.1	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing leucine-rich repeat 2	470					positive regulation of axon extension	cell surface|integral to membrane|plasma membrane				breast(3)|endometrium(6)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	36						TACGTTTCTAACCACGCGTTC	0.662000													8	10					0	0	0.000442599	0	0
NDST3	9348	broad.mit.edu	37	4	118975867	118975867	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr4:118975867C>T	ENST00000296499.5	+	2	1205	c.802C>T	c.(802-804)Caa>Taa	p.Q268*	NDST3_ENST00000433996.2_Nonsense_Mutation_p.Q268*	NM_004784.2	NP_004775.1	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	268	Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	54						TGATGGAATTCAAAGGGTTCT	0.418000													45	80					0	0	0.00285205	0	0
TINF2	26277	broad.mit.edu	37	14	24709293	24709293	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr14:24709293C>T	ENST00000267415.7	-	8	1539	c.1198G>A	c.(1198-1200)Gaa>Aaa	p.E400K	TINF2_ENST00000538777.1_3'UTR|TINF2_ENST00000399423.4_3'UTR|TINF2_ENST00000540705.1_Missense_Mutation_p.E365K|TINF2_ENST00000558566.1_3'UTR	NM_001099274.1	NP_001092744.1	Q9BSI4	TINF2_HUMAN	TERF1 (TRF1)-interacting nuclear factor 2	400					negative regulation of epithelial cell proliferation|negative regulation of protein ADP-ribosylation|negative regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance|protein localization to chromosome, telomeric region|telomere assembly|telomere maintenance via telomere lengthening	nuclear telomere cap complex|nucleoplasm|perinucleolar chromocenter	protein binding|telomeric DNA binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|prostate(1)|urinary_tract(1)	7				GBM - Glioblastoma multiforme(265;0.0185)		TGGCCATTTTCTTCCTCATCA	0.488000									Congenital Dyskeratosis;Ataxia Pancytopenia syndrome				57	185					0	0	0.000781405	0	0
TCERG1	10915	broad.mit.edu	37	5	145826962	145826962	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr5:145826962G>A	ENST00000296702.5	+	1	88	c.50G>A	c.(49-51)gGg>gAg	p.G17E	TCERG1_ENST00000394421.2_Missense_Mutation_p.G17E	NM_006706.3	NP_006697.2	O14776	TCRG1_HUMAN	transcription elongation regulator 1	17					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(18)|lung(9)|ovary(2)|prostate(3)|skin(1)	46		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCAACCCGGGGGAGCTCAGG	0.647000													8	10					0	0	0.000442599	0	0
PTPRT	11122	broad.mit.edu	37	20	40757431	40757431	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr20:40757431T>G	ENST00000373198.3	-	20	3111	c.2876A>C	c.(2875-2877)gAc>gCc	p.D959A	PTPRT_ENST00000373187.1_Missense_Mutation_p.D937A|PTPRT_ENST00000373190.1_Missense_Mutation_p.D936A|PTPRT_ENST00000373193.3_Missense_Mutation_p.D940A|PTPRT_ENST00000373184.1_Missense_Mutation_p.D927A|PTPRT_ENST00000373201.1_Missense_Mutation_p.D927A|PTPRT_ENST00000356100.2_Missense_Mutation_p.D946A	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	937	Tyrosine-protein phosphatase 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				AGAGTGCGGGTCTCCATCCAG	0.537000													25	37					0	0	0.000586117	0	0
ZIM2	23619	broad.mit.edu	37	19	57293402	57293402	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:57293402C>T	ENST00000391708.3	-	10	1107	c.565G>A	c.(565-567)Gaa>Aaa	p.E189K	ZIM2_ENST00000599935.1_Missense_Mutation_p.E189K|ZIM2_ENST00000593711.1_Missense_Mutation_p.E189K|ZIM2_ENST00000221722.5_Missense_Mutation_p.E189K|AC006115.3_ENST00000597946.1_RNA|ZIM2_ENST00000601070.1_Missense_Mutation_p.E189K|AC006115.3_ENST00000595954.1_RNA|AC006115.3_ENST00000594400.1_RNA	NM_001146326.1|NM_001146327.1	NP_001139798.1|NP_001139799.1			zinc finger, imprinted 2									p.E189*(2)		NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		GAACTAAGTTCCTCTGGGCTG	0.507000													57	68					0	0	0.000781405	0	0
SYBU	55638	broad.mit.edu	37	8	110631220	110631220	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr8:110631220G>A	ENST00000399066.3	-	2	996	c.269C>T	c.(268-270)cCc>cTc	p.P90L	SYBU_ENST00000440310.1_Missense_Mutation_p.P93L|SYBU_ENST00000532779.1_Missense_Mutation_p.P25L|SYBU_ENST00000424158.2_Missense_Mutation_p.P98L|SYBU_ENST00000533065.1_5'UTR|SYBU_ENST00000276646.9_Missense_Mutation_p.P93L|SYBU_ENST00000408908.2_Missense_Mutation_p.P93L|SYBU_ENST00000446070.2_Missense_Mutation_p.P92L|SYBU_ENST00000533171.1_Missense_Mutation_p.P93L|SYBU_ENST00000408889.3_5'UTR|SYBU_ENST00000528331.1_5'UTR|SYBU_ENST00000533895.1_Missense_Mutation_p.P92L|SYBU_ENST00000528647.1_Missense_Mutation_p.P92L|SYBU_ENST00000419099.1_Missense_Mutation_p.P92L|SYBU_ENST00000422135.1_Missense_Mutation_p.P93L|SYBU_ENST00000433638.1_Missense_Mutation_p.P93L	NM_001099756.1	NP_001093226.1	Q9NX95	SYBU_HUMAN	syntabulin (syntaxin-interacting)	93	Ser-rich.|Sufficient for interaction with KIF5B.					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				NS(1)|breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	30						AGCATCTGAGGGTGTCTTCAC	0.463000													24	112					0	0	0.00047179	0	0
KRT4	3851	broad.mit.edu	37	12	53207774	53207774	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr12:53207774G>A	ENST00000551956.1	-	1	561	c.69C>T	c.(67-69)ggC>ggT	p.G23G	KRT4_ENST00000458244.2_Silent_p.G23G|KRT4_ENST00000293774.4_Silent_p.G97G			B4DRS2	B4DRS2_HUMAN	keratin 4	23						keratin filament	structural molecule activity			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						TCTTGCCACCGCCTACAATGG	0.617000													32	34					0	0	0.00283554	0	0
SLC35A2	7355	broad.mit.edu	37	X	48762211	48762211	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chrX:48762211G>A	ENST00000376521.1	-	4	1296	c.975C>T	c.(973-975)gcC>gcT	p.A325A	SLC35A2_ENST00000452555.2_Silent_p.A353A|SLC35A2_ENST00000376515.3_Intron|SLC35A2_ENST00000247138.5_Silent_p.A325A|SLC35A2_ENST00000445167.2_Intron|SLC35A2_ENST00000413561.2_Silent_p.A264A|SLC35A2_ENST00000376529.3_Intron	NM_001042498.2	NP_001035963.1	P78381	S35A2_HUMAN	solute carrier family 35 (UDP-galactose transporter), member A2	325					galactose metabolic process	Golgi membrane|integral to membrane|nucleus	sugar:hydrogen symporter activity|UDP-galactose transmembrane transporter activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(2)	15						CAGCGCCAAGGGCAAATAATG	0.587000													9	4					0	0	0.000442599	0	0
COG6	57511	broad.mit.edu	37	13	40251631	40251631	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr13:40251631T>C	ENST00000416691.1	+	5	555	c.455T>C	c.(454-456)gTt>gCt	p.V152A	COG6_ENST00000455146.3_Missense_Mutation_p.V152A	NM_001145079.1	NP_001138551.1	Q9Y2V7	COG6_HUMAN	component of oligomeric golgi complex 6	152					protein transport	Golgi membrane|Golgi transport complex				NS(1)|kidney(2)|large_intestine(5)|lung(4)|skin(1)	13		Lung NSC(96;0.000124)|Breast(139;0.0199)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.03e-09)|Epithelial(112;7e-07)|OV - Ovarian serous cystadenocarcinoma(117;0.00015)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.0168)		AGAGCTCAAGTTGCAGATGCC	0.373000													16	29					0	0	0.000308642	0	0
UBE3B	89910	broad.mit.edu	37	12	109954637	109954637	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr12:109954637C>T	ENST00000342494.3	+	19	2619	c.2024C>T	c.(2023-2025)tCt>tTt	p.S675F	UBE3B_ENST00000434735.2_Missense_Mutation_p.S675F|UBE3B_ENST00000280774.5_Missense_Mutation_p.S675F	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	675					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						GAAACCAGCTCTGCCTCCCCG	0.532000													36	20					0	0	0.000814825	0	0
NEU2	4759	broad.mit.edu	37	2	233899088	233899088	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:233899088C>T	ENST00000233840.3	+	2	464	c.464C>T	c.(463-465)tCc>tTc	p.S155F		NM_005383.2	NP_005374.2	Q9Y3R4	NEUR2_HUMAN	sialidase 2 (cytosolic sialidase)	155							exo-alpha-sialidase activity			endometrium(3)|large_intestine(2)|lung(10)|skin(2)|urinary_tract(1)	18		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		CGGGAGTGGTCCACCTTTGCA	0.657000													9	16					0	0	0.000673444	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40293202	40293202	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr15:40293202C>T	ENST00000263791.5	+	21	2979	c.2936C>T	c.(2935-2937)tCc>tTc	p.S979F	EIF2AK4_ENST00000382727.2_Missense_Mutation_p.S951F	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	979	Protein kinase 2.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		TCAGTCATCTCCTGGCTGTTG	0.517000													93	143					0	0	0.000781405	0	0
CD109	135228	broad.mit.edu	37	6	74493476	74493476	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr6:74493476A>T	ENST00000437994.2	+	19	2583	c.2152A>T	c.(2152-2154)Act>Tct	p.T718S	CD109_ENST00000422508.2_Missense_Mutation_p.T641S|CD109_ENST00000287097.5_Missense_Mutation_p.T718S	NM_001159587.1|NM_133493.3	NP_001153059.1|NP_598000.2	Q6YHK3	CD109_HUMAN	CD109 molecule	718						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TGATTCTATCACTTCTTGGGT	0.368000													31	15					0	0	0.001512	0	0
SLC35A5	55032	broad.mit.edu	37	3	112299671	112299671	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr3:112299671T>C	ENST00000492406.1	+	6	990	c.707T>C	c.(706-708)aTt>aCt	p.I236T	SLC35A5_ENST00000460713.1_3'UTR	NM_017945.2	NP_060415.1	Q9BS91	S35A5_HUMAN	solute carrier family 35, member A5	236						Golgi membrane|integral to membrane	nucleotide-sugar transmembrane transporter activity|sugar:hydrogen symporter activity			endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(4)|ovary(1)|skin(1)	11						CATGTTCTTATTATAGTCCAG	0.403000													37	35					0	0	0.000953801	0	0
RB1CC1	9821	broad.mit.edu	37	8	53569134	53569134	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr8:53569134C>T	ENST00000025008.5	-	15	3778	c.3255G>A	c.(3253-3255)caG>caA	p.Q1085Q	RB1CC1_ENST00000521611.1_Intron|RB1CC1_ENST00000435644.2_Silent_p.Q1085Q|RB1CC1_ENST00000539297.1_Silent_p.Q1085Q	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	1085					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding	p.Q1085Q(1)		NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				AGGTCTCCTTCTGCTGGGCTC	0.358000													35	49					0	0	0.00283554	0	0
APOBEC3D	140564	broad.mit.edu	37	22	39418954	39418954	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr22:39418954C>T	ENST00000216099.7	+	2	552	c.145C>T	c.(145-147)Ctt>Ttt	p.L49F	APOBEC3D_ENST00000427494.2_Missense_Mutation_p.L49F|APOBEC3D_ENST00000381568.4_Missense_Mutation_p.L49F	NM_152426.3	NP_689639.2	Q96AK3	ABC3D_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D	49					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)	11	Melanoma(58;0.04)					CTCAAATCTCCTTTGGGACAC	0.488000													40	51					0	0	0.00222228	0	0
SRGAP2	23380	broad.mit.edu	37	1	206619607	206619607	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:206619607C>T	ENST00000414007.1	+	14	1641	c.1641C>T	c.(1639-1641)ggC>ggT	p.G547G	SRGAP2_ENST00000419187.2_5'UTR|SRGAP2_ENST00000471256.1_3'UTR			O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	687	Rho-GAP.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			NS(1)|breast(1)|kidney(1)|lung(1)	4	Breast(84;0.137)					AGCTGGAGGGCCCTGTCTACA	0.587000													90	85					0	0	0.000781405	0	0
ANKRD11	29123	broad.mit.edu	37	16	89348234	89348234	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr16:89348234G>A	ENST00000301030.4	-	9	5176	c.4716C>T	c.(4714-4716)ctC>ctT	p.L1572L	ANKRD11_ENST00000378330.2_Silent_p.L1572L	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1572	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CGTCCCCCAGGAGCTTCTCCC	0.577000													9	22					0	0	0.000442599	0	0
C5AR2	27202	broad.mit.edu	37	19	47844173	47844173	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:47844173C>T	ENST00000595464.1	+	2	335	c.117C>T	c.(115-117)ctC>ctT	p.L39L	C5AR2_ENST00000257267.2_Silent_p.L39L|C5AR2_ENST00000600626.1_Silent_p.L39L	NM_001271749.1	NP_001258678.1			complement component 5a receptor 2																		TGGCCCCGCTCCCACTGTATG	0.692000													37	43					0	0	0.00195071	0	0
SUSD4	55061	broad.mit.edu	37	1	223438040	223438040	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:223438040G>T	ENST00000343846.3	-	4	1289	c.656C>A	c.(655-657)tCt>tAt	p.S219Y	SUSD4_ENST00000366878.4_Missense_Mutation_p.S219Y|SUSD4_ENST00000454695.2_Missense_Mutation_p.S59Y|SUSD4_ENST00000478605.1_Intron|SUSD4_ENST00000344029.6_Missense_Mutation_p.S219Y			Q5VX71	SUSD4_HUMAN	sushi domain containing 4	219	Sushi 3.					integral to membrane				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(131;0.0611)		AAGATACGCAGACCCATCAAG	0.488000													57	53					4.45325e-31	1.95209e-30	0.000781405	1	0
ATXN7L2	127002	broad.mit.edu	37	1	110033883	110033883	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:110033883G>A	ENST00000369870.3	+	10	1713	c.1698G>A	c.(1696-1698)gaG>gaA	p.E566E	ATXN7L2_ENST00000459635.1_3'UTR	NM_153340.4	NP_699171.3	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	566										breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)	17		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		TGGAGGTGGAGGCCCCTTCTC	0.607000													197	154					0	0	0.000781405	0	0
ACD	65057	broad.mit.edu	37	16	67694194	67694194	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr16:67694194G>A	ENST00000219251.8	-	1	519	c.188C>T	c.(187-189)cCg>cTg	p.P63L	ACD_ENST00000393919.4_Missense_Mutation_p.P63L	NM_001082486.1|NM_001082487.1|NM_022914.2	NP_001075955.1|NP_001075956.1|NP_075065.2	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog (mouse)	63					intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	17		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		GCCTTTCCTCGGAAGAGGAAG	0.741000													16	5					0	0	0.000308642	0	0
TNS4	84951	broad.mit.edu	37	17	38635928	38635928	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr17:38635928C>T	ENST00000254051.6	-	10	2066	c.1908G>A	c.(1906-1908)agG>agA	p.R636R		NM_032865.5	NP_116254.4	Q8IZW8	TENS4_HUMAN	tensin 4	636	Phosphatase tensin-type.				apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	30		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			GCCCTTACTTCCTCTGGACAT	0.587000													20	34					0	0	0.00229938	0	0
PDE8A	5151	broad.mit.edu	37	15	85657248	85657248	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr15:85657248C>T	ENST00000310298.4	+	15	1582	c.1330C>T	c.(1330-1332)Ctt>Ttt	p.L444F	PDE8A_ENST00000394553.1_Missense_Mutation_p.L444F|PDE8A_ENST00000557957.1_Missense_Mutation_p.L372F|PDE8A_ENST00000339708.5_Missense_Mutation_p.L398F			O60658	PDE8A_HUMAN	phosphodiesterase 8A	444					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	25	Colorectal(223;0.227)		BRCA - Breast invasive adenocarcinoma(143;0.0608)			TGCCAATGACCTTGTTGGGGG	0.423000													32	38					0	0	0.00283554	0	0
DIDO1	11083	broad.mit.edu	37	20	61537178	61537178	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr20:61537178G>A	ENST00000370371.4	-	6	2004	c.1649C>T	c.(1648-1650)cCc>cTc	p.P550L	DIDO1_ENST00000370366.1_Intron|DIDO1_ENST00000370368.1_Missense_Mutation_p.P550L|DIDO1_ENST00000395340.1_Intron|DIDO1_ENST00000354665.4_Missense_Mutation_p.P550L|DIDO1_ENST00000395343.1_Intron|DIDO1_ENST00000395335.2_Intron|DIDO1_ENST00000266070.4_Intron|DIDO1_ENST00000266071.5_Intron	NM_022105.4	NP_071388.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	0					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					ACAGGCCCAGGGGATGGCTAT	0.562000													47	51					0	0	0.000781405	0	0
C2orf16	84226	broad.mit.edu	37	2	27804224	27804224	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:27804224G>A	ENST00000408964.2	+	1	4836	c.4785G>A	c.(4783-4785)agG>agA	p.R1595R		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	1595	27 X 8 AA approximative tandem repeat of P-S-E-R-S-H-H-S.|Arg-rich.									breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					GTCCCTCTAGGAAAAACCATT	0.547000													39	50					0	0	0.00170553	0	0
SYTL3	94120	broad.mit.edu	37	6	159086619	159086619	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr6:159086619G>A	ENST00000297239.9	+	4	497	c.303G>A	c.(301-303)tgG>tgA	p.W101*	SYTL3_ENST00000360448.3_Nonsense_Mutation_p.W101*|SYTL3_ENST00000367081.3_5'UTR			Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	101	RabBD.				intracellular protein transport	endomembrane system|membrane	Rab GTPase binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|urinary_tract(1)	20		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		CCCATGCCTGGAAGTGCACGG	0.642000													3	1					0	0	0.00024832	0	0
TAS2R5	54429	broad.mit.edu	37	7	141490305	141490305	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr7:141490305C>T	ENST00000247883.4	+	1	289	c.144C>T	c.(142-144)atC>atT	p.I48I		NM_018980.2	NP_061853.1	Q9NYW4	TA2R5_HUMAN	taste receptor, type 2, member 5	48					chemosensory behavior|sensory perception of taste		taste receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(2)|skin(1)	9	Melanoma(164;0.0171)					ACCTCATTATCCTGGGCCTGG	0.448000													70	5					0	0	0.000781405	0	0
RYR3	6263	broad.mit.edu	37	15	34080580	34080580	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr15:34080580A>C	ENST00000389232.4	+	67	9821	c.9751A>C	c.(9751-9753)Atc>Ctc	p.I3251L	RYR3_ENST00000415757.3_Missense_Mutation_p.I3251L	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3251					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AGAACTCCTCATCCTGGACGA	0.552000													45	65					0	0	0.000680045	0	0
NEB	4703	broad.mit.edu	37	2	152507246	152507246	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:152507246A>T	ENST00000427231.2	-	53	7271	c.7069T>A	c.(7069-7071)Ttc>Atc	p.F2357I	NEB_ENST00000604864.1_Missense_Mutation_p.F2357I|NEB_ENST00000603639.1_Missense_Mutation_p.F2357I|NEB_ENST00000397345.3_Missense_Mutation_p.F2357I|NEB_ENST00000172853.10_Missense_Mutation_p.F2357I|NEB_ENST00000409198.1_Missense_Mutation_p.F2357I	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	2357					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GGGCTGGAGAACTTAGTTTTC	0.458000													190	219					0	0	0.000781405	0	0
OR4M1	441670	broad.mit.edu	37	14	20248980	20248980	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr14:20248980C>T	ENST00000315957.4	+	1	580	c.499C>T	c.(499-501)Cct>Tct	p.P167S		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGTTCGACTTCCTTTCTGTGG	0.488000													86	163					0	0	0.000781405	0	0
DDX41	51428	broad.mit.edu	37	5	176940758	176940758	+	Silent	SNP	G	G	C			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr5:176940758G>C	ENST00000507955.1	-	10	1549	c.1026C>G	c.(1024-1026)gcC>gcG	p.A342A		NM_016222.2	NP_057306.2	Q9UJV9	DDX41_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 41	342	Helicase ATP-binding.				apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding					all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			CCTCGTCCAGGGCCAGGTAGC	0.627000													9	57					0	0	0.000673444	0	0
THADA	63892	broad.mit.edu	37	2	43819134	43819134	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:43819134A>C	ENST00000403856.1	-	4	275	c.128T>G	c.(127-129)gTg>gGg	p.V43G	THADA_ENST00000404790.1_Missense_Mutation_p.V43G|THADA_ENST00000405006.4_Missense_Mutation_p.V43G|THADA_ENST00000405975.2_Missense_Mutation_p.V43G|THADA_ENST00000415080.2_5'UTR|THADA_ENST00000402360.2_Missense_Mutation_p.V43G			Q6YHU6	THADA_HUMAN	thyroid adenoma associated	43							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				CGTGAGTTGCACACAATGTAA	0.318000													152	208					0	0	0.000781405	0	0
NKD2	85409	broad.mit.edu	37	5	1034434	1034434	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr5:1034434G>A	ENST00000296849.5	+	6	644	c.415G>A	c.(415-417)Gtc>Atc	p.V139I	NKD2_ENST00000274150.4_Missense_Mutation_p.V139I|NKD2_ENST00000537972.1_Missense_Mutation_p.V139I	NM_033120.2	NP_149111.1	Q969F2	NKD2_HUMAN	naked cuticle homolog 2 (Drosophila)	139	EF-hand.|Interaction with DVL1, DVL2 and DVL3 (By similarity).|Targeting to the basolateral cell membrane.				exocytosis|Wnt receptor signaling pathway	cytoplasmic membrane-bounded vesicle|plasma membrane	calcium ion binding|ubiquitin protein ligase binding			breast(1)|central_nervous_system(3)|large_intestine(1)|lung(8)|pancreas(1)	14	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;3.28e-09)		Epithelial(17;0.00093)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00417)|Lung(60;0.165)			CTGCGGGAAGGTCACCAGGGA	0.612000													13	15					0	0	0.000308642	0	0
PLXNA1	5361	broad.mit.edu	37	3	126707544	126707544	+	Silent	SNP	T	T	G			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr3:126707544T>G	ENST00000393409.2	+	1	108	c.108T>G	c.(106-108)ggT>ggG	p.G36G	PLXNA1_ENST00000251772.4_Silent_p.G13G	NM_032242.3	NP_115618.3	Q9UIW2	PLXA1_HUMAN	plexin A1	36	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity	p.G13G(4)		breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		CAGGCGGGGGTTCACAGCCCC	0.682000													6	20					0	0	0.00198382	0	0
TEX30	93081	broad.mit.edu	37	13	103419826	103419826	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr13:103419826G>A	ENST00000376019.1	-	3	1014	c.178C>T	c.(178-180)Cgt>Tgt	p.R60C	TEX30_ENST00000376022.1_Intron|TEX30_ENST00000376032.4_Missense_Mutation_p.R101C|TEX30_ENST00000376021.4_Missense_Mutation_p.R60C|TEX30_ENST00000376027.1_Intron|TEX30_ENST00000376029.3_Intron			Q5JUR7	CM027_HUMAN	testis expressed 30	101										lung(1)|urinary_tract(1)	2						CCCATTGAACGACCTAAAATC	0.363000													17	6					0	0	0.000958276	0	0
FAM83B	222584	broad.mit.edu	37	6	54804969	54804969	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr6:54804969C>T	ENST00000306858.7	+	5	1316	c.1200C>T	c.(1198-1200)ctC>ctT	p.L400L		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	400										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					TGCCATACCTCCTGCTTAATA	0.443000													52	34					0	0	0.000781405	0	0
SCRN3	79634	broad.mit.edu	37	2	175268966	175268966	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:175268966C>T	ENST00000272732.6	+	5	759	c.677C>T	c.(676-678)tCc>tTc	p.S226F	SCRN3_ENST00000409673.3_Missense_Mutation_p.S219F	NM_001193528.1|NM_024583.4	NP_001180457.1|NP_078859.2	Q0VDG4	SCRN3_HUMAN	secernin 3	226					proteolysis		dipeptidase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|urinary_tract(3)	13			OV - Ovarian serous cystadenocarcinoma(117;0.229)			GCAGCATATTCCTATCTTGAC	0.403000													23	20					0	0	0.000720815	0	0
WNK2	65268	broad.mit.edu	37	9	96051722	96051722	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr9:96051722G>A	ENST00000297954.4	+	20	4797	c.4797G>A	c.(4795-4797)caG>caA	p.Q1599Q	WNK2_ENST00000395477.2_Silent_p.Q1562Q|WNK2_ENST00000427277.2_Silent_p.Q1174Q|WNK2_ENST00000395475.2_3'UTR|WNK2_ENST00000356055.3_5'UTR|WNK2_ENST00000349097.3_Silent_p.Q1211Q			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1599					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						TGCTCTACCAGGAGCACGTGC	0.677000													21	11					0	0	0.000878237	0	0
PDS5A	23244	broad.mit.edu	37	4	39876033	39876033	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr4:39876033C>T	ENST00000303538.8	-	20	2693		c.e20-1			NM_001100399.1	NP_001093869.1	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)						cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding			breast(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(9)|lung(14)|prostate(3)|skin(1)|urinary_tract(1)	39						AATTAAGGTCCTGCAAAAAAT	0.368000													22	23					0	0	0.00278032	0	0
MYH8	4626	broad.mit.edu	37	17	10319023	10319023	+	Nonsense_Mutation	SNP	G	G	A	rs143063345		TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr17:10319023G>A	ENST00000403437.2	-	6	608	c.514C>T	c.(514-516)Cga>Tga	p.R172*	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	172	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						TGATTCTCTCGATCTGTGAAA	0.333000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				25	13					0	0	0.00106085	0	0
PCDHA5	56143	broad.mit.edu	37	5	140201883	140201883	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr5:140201883G>A	ENST00000529859.1	+	1	523	c.523G>A	c.(523-525)Gaa>Aaa	p.E175K	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000378126.3_Missense_Mutation_p.E175K|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Missense_Mutation_p.E175K|PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAATCCAAACGAATATTTTGA	0.388000													36	7					0	0	0.00283554	0	0
ADCY8	114	broad.mit.edu	37	8	131859707	131859707	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr8:131859707G>A	ENST00000286355.5	-	11	4557	c.2465C>T	c.(2464-2466)tCc>tTc	p.S822F	ADCY8_ENST00000377928.3_Intron	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	822					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CACAGCTGAGGAATTGAAAGT	0.383000										HNSCC(32;0.087)			36	87					0	0	0.000680045	0	0
OR1D2	4991	broad.mit.edu	37	17	2995663	2995663	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr17:2995663G>A	ENST00000331459.1	-	1	627	c.628C>T	c.(628-630)Ccc>Tcc	p.P210S		NM_002548.2	NP_002539.2	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D, member 2	210					cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(2)|lung(10)|ovary(1)	15						AATCCAAAGGGAATGAGGAAG	0.443000													62	69					0	0	0.000781405	0	0
CTC-260E6.6	0	broad.mit.edu	37	19	20368605	20368605	+	RNA	SNP	A	A	G			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:20368605A>G	ENST00000593655.1	-	0	199																											GCAGGCTCCAACTTTCCAGAA	0.483000													34	61					0	0	0.00148497	0	0
NEU4	129807	broad.mit.edu	37	2	242756224	242756224	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:242756224G>A	ENST00000391969.2	+	4	1048	c.337G>A	c.(337-339)Gtg>Atg	p.V113M	NEU4_ENST00000407683.1_Missense_Mutation_p.V113M|NEU4_ENST00000405370.1_Missense_Mutation_p.V113M|NEU4_ENST00000325935.6_Missense_Mutation_p.V126M|NEU4_ENST00000404257.1_Missense_Mutation_p.V125M	NM_001167602.1	NP_001161074.1	Q8WWR8	NEUR4_HUMAN	sialidase 4	113						lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding			breast(1)|lung(10)|prostate(2)|skin(2)	15		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		GCCTGAGGCCGTGCAGATCGC	0.711000													5	8					0	0	0.000602214	0	0
SLITRK6	84189	broad.mit.edu	37	13	86369000	86369000	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr13:86369000G>A	ENST00000400286.2	-	2	2242	c.1644C>T	c.(1642-1644)tcC>tcT	p.S548S		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	548	LRRCT 2.					integral to membrane		p.S548*(1)		breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		GATGCCCGGGGGAAGTGCAGA	0.463000													36	24					0	0	0.000814825	0	0
EML5	161436	broad.mit.edu	37	14	89131701	89131701	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr14:89131701G>A	ENST00000554922.1	-	22	3505	c.3257C>T	c.(3256-3258)tCa>tTa	p.S1086L	EML5_ENST00000380664.5_Missense_Mutation_p.S1086L|EML5_ENST00000352093.5_Missense_Mutation_p.S1048L	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	1086						cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						TCGAATATCTGAAATCATATC	0.338000													17	11					0	0	0.00074312	0	0
ZSWIM5	57643	broad.mit.edu	37	1	45506071	45506071	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:45506071C>T	ENST00000359600.5	-	7	1954	c.1749G>A	c.(1747-1749)caG>caA	p.Q583Q		NM_020883.1	NP_065934.1	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM-type containing 5	583							zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|liver(1)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	28	Acute lymphoblastic leukemia(166;0.155)					TACCTTTCTTCTGATGCTTGT	0.488000													42	36					0	0	0.000781405	0	0
ADAM20	8748	broad.mit.edu	37	14	70990899	70990899	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr14:70990899G>A	ENST00000256389.3	-	2	970	c.726C>T	c.(724-726)ttC>ttT	p.F242F	RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003814.4	NP_003805.3	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20	192	Peptidase M12B.				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(2)	27			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		GCTTCAGAGTGAAATTATATG	0.398000													14	12					0	0	0.00185496	0	0
RGS12	6002	broad.mit.edu	37	4	3318359	3318359	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr4:3318359G>A	ENST00000336727.3	+	2	1366	c.462G>A	c.(460-462)ccG>ccA	p.P154P	RGS12_ENST00000382788.3_Silent_p.P154P|RGS12_ENST00000543385.1_Silent_p.P154P|RGS12_ENST00000344733.5_Silent_p.P154P	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	154						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TTGAAAACCCGAGCCTTTGTG	0.428000													8	32					0	0	0.000442599	0	0
OR10J5	127385	broad.mit.edu	37	1	159505705	159505705	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:159505705G>A	ENST00000334857.2	-	1	137	c.93C>T	c.(91-93)ttC>ttT	p.F31F		NM_001004469.1	NP_001004469.1	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J, member 5	31					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	22	all_hematologic(112;0.0429)					AGACAGTTAGGAAAACCACAA	0.378000													18	41					0	0	0.00152264	0	0
DNAH5	1767	broad.mit.edu	37	5	13780959	13780959	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr5:13780959G>A	ENST00000265104.4	-	53	9034	c.8930C>T	c.(8929-8931)tCc>tTc	p.S2977F		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2977	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GATCTGGAAGGAAACGTAGCC	0.488000									Kartagener syndrome				9	17					0	0	0.000442599	0	0
BDKRB1	623	broad.mit.edu	37	14	96730324	96730324	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr14:96730324A>G	ENST00000216629.6	+	3	911	c.305A>G	c.(304-306)aAc>aGc	p.N102S	RP11-404P21.3_ENST00000553638.1_RNA|BDKRB1_ENST00000553356.1_Missense_Mutation_p.N102S	NM_000710.3	NP_000701.2	P46663	BKRB1_HUMAN	bradykinin receptor B1	102					elevation of cytosolic calcium ion concentration	endoplasmic reticulum|integral to plasma membrane	bradykinin receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(4)|skin(1)|urinary_tract(1)	16		all_cancers(154;0.0677)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.208)|Epithelial(152;0.226)		AACCAGTTTAACTGGCCTTTC	0.552000													30	24					0	0	0.00209593	0	0
CWF19L2	143884	broad.mit.edu	37	11	107260890	107260890	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr11:107260890A>C	ENST00000282251.5	-	12	1809	c.1782T>G	c.(1780-1782)gaT>gaG	p.D594E	CWF19L2_ENST00000433523.1_Missense_Mutation_p.D594E	NM_152434.2	NP_689647.2	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control (S. pombe)	594							catalytic activity			endometrium(4)|kidney(2)|large_intestine(13)|lung(21)	40		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		TTAGATTATCATCATCATGAA	0.313000													17	34					0	0	0.00074312	0	0
LRP2	4036	broad.mit.edu	37	2	170032974	170032974	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:170032974G>A	ENST00000263816.3	-	54	10803	c.10518C>T	c.(10516-10518)acC>acT	p.T3506T		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3506	EGF-like 13.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GCATGCAGTAGGTGCTGCCAC	0.552000													23	29					0	0	0.00229938	0	0
GJB6	10804	broad.mit.edu	37	13	20796916	20796916	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr13:20796916G>A	ENST00000356192.6	-	5	1324	c.704C>T	c.(703-705)gCc>gTc	p.A235V	GJB6_ENST00000400066.3_Missense_Mutation_p.A235V|GJB6_ENST00000400065.3_Missense_Mutation_p.A235V|GJB6_ENST00000241124.6_Missense_Mutation_p.A235V	NM_001110219.2	NP_001103689.1	O95452	CXB6_HUMAN	gap junction protein, beta 6, 30kDa	235					cell communication|sensory perception of sound	connexon complex|integral to membrane|intracellular membrane-bounded organelle				biliary_tract(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)	9		all_cancers(29;2.04e-22)|all_epithelial(30;1.19e-19)|all_lung(29;2.27e-18)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;2.17e-05)|Epithelial(112;0.00075)|OV - Ovarian serous cystadenocarcinoma(117;0.00978)|Lung(94;0.0238)|GBM - Glioblastoma multiforme(144;0.0323)|LUSC - Lung squamous cell carcinoma(192;0.0744)		CTCCTTTAGGGCATGATTGGG	0.418000													36	59					0	0	0.000692331	0	0
DYNC1LI1	51143	broad.mit.edu	37	3	32587396	32587396	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr3:32587396C>T	ENST00000273130.4	-	3	385	c.282G>A	c.(280-282)aaG>aaA	p.K94K	DYNC1LI1_ENST00000432458.2_Intron	NM_016141.3	NP_057225.2	Q9Y6G9	DC1L1_HUMAN	dynein, cytoplasmic 1, light intermediate chain 1	94					cell division|interspecies interaction between organisms|mitosis|positive regulation of mitotic cell cycle spindle assembly checkpoint|transport	centrosome|condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|plasma membrane|spindle pole	ATP binding|motor activity			kidney(2)|large_intestine(1)|lung(3)|ovary(1)	7						CTCTTCCTTTCTTATACTCCT	0.308000													12	37					0	0	0.000978159	0	0
ALDH3B1	221	broad.mit.edu	37	11	67790121	67790121	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr11:67790121C>G	ENST00000539229.1	+	10	1118	c.1002C>G	c.(1000-1002)ttC>ttG	p.F334L	ALDH3B1_ENST00000342456.6_Missense_Mutation_p.F298L|ALDH3B1_ENST00000007633.8_Missense_Mutation_p.F334L|ALDH3B1_ENST00000434449.1_3'UTR|ALDH3B1_ENST00000316367.6_Intron	NM_001161473.1	NP_001154945.1	P43353	AL3B1_HUMAN	aldehyde dehydrogenase 3 family, member B1	336					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase									NADH(DB00157)	AGGAGATCTTCGGGCCCATCC	0.632000													41	31					0	0	0.000781405	0	0
CHST11	50515	broad.mit.edu	37	12	105150791	105150791	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr12:105150791G>A	ENST00000303694.5	+	3	708	c.269G>A	c.(268-270)cGa>cAa	p.R90Q	CHST11_ENST00000549260.1_Missense_Mutation_p.R85Q	NM_018413.5	NP_060883.1	Q9NPF2	CHSTB_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 11	90					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			breast(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(1)	18						GACACGTGCCGAGCCAACAGC	0.582000													21	12					0	0	0.00229938	0	0
MYH7B	57644	broad.mit.edu	37	20	33583241	33583241	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr20:33583241G>A	ENST00000262873.7	+	26	3021	c.2929G>A	c.(2929-2931)Gat>Aat	p.D977N		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	935						membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			GCGGCTGGAGGATGAGGAGGA	0.617000													6	7					0	0	0.00116845	0	0
PTEN	5728	broad.mit.edu	37	10	89692839	89692839	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr10:89692839T>C	ENST00000371953.3	+	5	1680	c.323T>C	c.(322-324)cTt>cCt	p.L108P		NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	108	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.?(5)|p.R55fs*1(5)|p.L108R(3)|p.Y27fs*1(2)|p.L108_D109del(2)|p.F56fs*2(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TGTGAAGATCTTGACCAATGG	0.373000		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			56	6					0	0	0.000781405	0	0
VWF	7450	broad.mit.edu	37	12	6173510	6173510	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr12:6173510G>A	ENST00000261405.5	-	12	1588	c.1334C>T	c.(1333-1335)aCc>aTc	p.T445I		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	445	VWFD 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	CAGCCGGACGGTGACGGAGCG	0.632000													12	11					0	0	0.00244969	0	0
FAM129B	64855	broad.mit.edu	37	9	130269197	130269197	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr9:130269197A>T	ENST00000373312.3	-	14	2381	c.2168T>A	c.(2167-2169)gTg>gAg	p.V723E	FAM129B_ENST00000373314.3_Missense_Mutation_p.V710E	NM_022833.2	NP_073744.2	Q96TA1	NIBL1_HUMAN	family with sequence similarity 129, member B	723							protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						GGGGCTGGACACCTGCTCTCC	0.672000													31	50					0	0	0.00283554	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102452896	102452896	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr14:102452896C>T	ENST00000360184.4	+	8	2498	c.2334C>T	c.(2332-2334)gcC>gcT	p.A778A		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	778	Interaction with DYNC1LI2 (By similarity).|Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						ACCCGTTTGCCATCTCACTGA	0.517000													48	35					0	0	0.000781405	0	0
TMEM9	252839	broad.mit.edu	37	1	201113056	201113056	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:201113056G>A	ENST00000367330.1	-	4	807	c.291C>T	c.(289-291)tcC>tcT	p.S97S	TMEM9_ENST00000367333.1_Silent_p.S100S|TMEM9_ENST00000367334.5_Silent_p.S97S|TMEM9_ENST00000472411.1_5'UTR|TMEM9_ENST00000367332.1_Silent_p.S100S|TMEM9_ENST00000367329.1_Silent_p.S97S			Q9P0T7	TMEM9_HUMAN	transmembrane protein 9	97					transport	integral to membrane|late endosome membrane|lysosomal membrane				liver(1)|lung(1)|stomach(1)	3		Breast(1374;0.000301)				CACCCACCACGGACAGGTAGA	0.542000													5	37					0	0	0.00116845	0	0
GRTP1	79774	broad.mit.edu	37	13	113999256	113999256	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr13:113999256C>T	ENST00000375430.4	-	5	530	c.484G>A	c.(484-486)Gga>Aga	p.G162R	GRTP1_ENST00000326039.3_Missense_Mutation_p.G84R|GRTP1_ENST00000375431.4_Missense_Mutation_p.G162R			Q5TC63	GRTP1_HUMAN	growth hormone regulated TBC protein 1	162	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	14	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0314)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0978)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			ATCAGATATCCTGCTATAAAA	0.338000													40	32					0	0	0.00148497	0	0
RNF19A	25897	broad.mit.edu	37	8	101300197	101300197	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr8:101300197G>A	ENST00000519449.1	-	3	522	c.206C>T	c.(205-207)tCc>tTc	p.S69F	RNF19A_ENST00000341084.2_Missense_Mutation_p.S69F	NM_015435.3	NP_056250.3	Q9NV58	RN19A_HUMAN	ring finger protein 19A, RBR E3 ubiquitin protein ligase	69					microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	30	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			CCGAAACAGGGAGCCTATTGA	0.418000													60	84					0	0	0.000781405	0	0
MOCOS	55034	broad.mit.edu	37	18	33795660	33795660	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr18:33795660G>A	ENST00000261326.5	+	8	1538	c.1517G>A	c.(1516-1518)gGg>gAg	p.G506E		NM_017947.2	NP_060417.2	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	506					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|liver(1)|lung(15)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43					Pyridoxal Phosphate(DB00114)	GCTGACACCGGGGAGACTGGA	0.592000													7	12					0	0	0.00198382	0	0
COL6A6	131873	broad.mit.edu	37	3	130318624	130318624	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr3:130318624C>T	ENST00000358511.6	+	19	4654	c.4623C>T	c.(4621-4623)ccC>ccT	p.P1541P	COL6A6_ENST00000453409.2_Silent_p.P1541P	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	1541	Triple-helical region.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						GGCCAGGCCCCCCCGGGACAC	0.488000													9	22					0	0	0.000978159	0	0
ZC3H12C	85463	broad.mit.edu	37	11	110035104	110035104	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr11:110035104C>T	ENST00000453089.2	+	5	2082	c.1201C>T	c.(1201-1203)Cat>Tat	p.H401Y	ZC3H12C_ENST00000278590.3_Missense_Mutation_p.H432Y|ZC3H12C_ENST00000528673.1_Missense_Mutation_p.H433Y			Q9C0D7	ZC12C_HUMAN	zinc finger CCCH-type containing 12C	432							endonuclease activity|nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		all_cancers(61;3.24e-13)|all_epithelial(67;1.27e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.72e-06)|BRCA - Breast invasive adenocarcinoma(274;1.17e-05)|all cancers(92;9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0279)		CAAATATTACCATCCCGAAAG	0.458000													7	18					0	0	0.000157383	0	0
HSPG2	3339	broad.mit.edu	37	1	22174253	22174253	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:22174253C>T	ENST00000374695.3	-	61	8033	c.7954G>A	c.(7954-7956)Gtg>Atg	p.V2652M	HSPG2_ENST00000430507.1_3'UTR	NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	2652	Ig-like C2-type 12.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding	p.V2652M(2)		breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CTGGCGACCACGCAGTTCAGA	0.647000													6	10					0	0	0.00116845	0	0
SLC36A4	120103	broad.mit.edu	37	11	92916041	92916041	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr11:92916041A>G	ENST00000326402.4	-	4	420	c.290T>C	c.(289-291)gTg>gCg	p.V97A	SLC36A4_ENST00000529184.1_5'UTR	NM_152313.2	NP_689526.2	Q6YBV0	S36A4_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 4	97					L-alanine transport|proline transport|tryptophan transport	integral to membrane	symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	25		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TCCTATAAACACAAGGCTGAT	0.308000													175	214					0	0	0.000781405	0	0
DNAH3	55567	broad.mit.edu	37	16	21098222	21098222	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr16:21098222G>A	ENST00000261383.3	-	19	2824	c.2825C>T	c.(2824-2826)cCc>cTc	p.P942L	DNAH3_ENST00000415178.1_Missense_Mutation_p.P942L	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	942	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		ACTGAGGATGGGAATGTACTG	0.512000													66	156					0	0	0.000781405	0	0
L1TD1	54596	broad.mit.edu	37	1	62672641	62672641	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr1:62672641G>A	ENST00000498273.1	+	3	636	c.341G>A	c.(340-342)gGg>gAg	p.G114E		NM_001164835.1|NM_019079.4	NP_001158307.1|NP_061952.3	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	114										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	35						caaaaaacagggatggtaggg	0.333000													80	76					0	0	0.000781405	0	0
IGSF9B	22997	broad.mit.edu	37	11	133790544	133790544	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr11:133790544G>A	ENST00000321016.8	-	18	3306	c.3076C>T	c.(3076-3078)Ccc>Tcc	p.P1026S	IGSF9B_ENST00000533871.2_Missense_Mutation_p.P1026S			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	1026	Pro-rich.					integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		TGAGTCAAGGGCAGCGTGCTG	0.667000													33	53					0	0	0.00170553	0	0
TTN	7273	broad.mit.edu	37	2	179611971	179611971	+	Silent	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:179611971G>A	ENST00000360870.5	-	46	15378	c.15156C>T	c.(15154-15156)tcC>tcT	p.S5052S	TTN_ENST00000342175.6_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000589042.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	1159	Ig-like 31.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGGGGGTGTGGAGTATCTTT	0.483000													21	32					0	0	0.00152264	0	0
ZMYM2	7750	broad.mit.edu	37	13	20641482	20641482	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr13:20641482G>T	ENST00000382869.3	+	21	3656	c.3405G>T	c.(3403-3405)gaG>gaT	p.E1135D	ZMYM2_ENST00000382871.2_Missense_Mutation_p.E1135D|ZMYM2_ENST00000494061.1_3'UTR|ZMYM2_ENST00000382874.2_Missense_Mutation_p.E1135D|ZMYM2_ENST00000382870.2_Missense_Mutation_p.E515D	NM_001190965.1|NM_003453.3|NM_197968.2	NP_001177894.1|NP_003444.1|NP_932072.1	Q9UBW7	ZMYM2_HUMAN	zinc finger, MYM-type 2	1135					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	10		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		CAAATGGAGAGAATTATGCAC	0.388000													7	12					8.12818e-05	0.000346458	0.00198382	1	0
OR1J2	26740	broad.mit.edu	37	9	125273649	125273649	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr9:125273649C>T	ENST00000335302.5	+	1	569	c.569C>T	c.(568-570)tCa>tTa	p.S190L		NM_054107.1	NP_473448.1	Q8NGS2	OR1J2_HUMAN	olfactory receptor, family 1, subfamily J, member 2	190					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(7)|stomach(1)	26						CTGTCCTGCTCAGATATCTTC	0.532000													44	37					0	0	0.000680045	0	0
TMEM119	338773	broad.mit.edu	37	12	108985408	108985408	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr12:108985408C>T	ENST00000392806.3	-	2	920	c.752G>A	c.(751-753)gGg>gAg	p.G251E		NM_181724.2	NP_859075.2	Q4V9L6	TM119_HUMAN	transmembrane protein 119	251						integral to membrane				large_intestine(2)|lung(3)|ovary(1)|skin(1)	7						TTCCAGCTCCCCTTGGCCCTC	0.652000													46	88					0	0	0.000781405	0	0
TG	7038	broad.mit.edu	37	8	134144060	134144060	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr8:134144060G>A	ENST00000220616.4	+	46	7907	c.7867G>A	c.(7867-7869)Gag>Aag	p.E2623K	TG_ENST00000377869.1_Missense_Mutation_p.E2566K|TG_ENST00000519543.1_Missense_Mutation_p.E756K|TG_ENST00000542445.1_Missense_Mutation_p.E993K	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2623					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TCTCAGCCTGGAGCTGCTGGC	0.458000													39	57					0	0	0.00170553	0	0
TACC2	10579	broad.mit.edu	37	10	123997041	123997041	+	Silent	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr10:123997041C>T	ENST00000369005.1	+	17	8599	c.8259C>T	c.(8257-8259)atC>atT	p.I2753I	TACC2_ENST00000368999.1_Silent_p.I843I|TACC2_ENST00000358010.1_Silent_p.I899I|TACC2_ENST00000453444.2_Silent_p.I2680I|TACC2_ENST00000360561.3_Silent_p.I801I|TACC2_ENST00000369000.1_Silent_p.I376I|TACC2_ENST00000369004.3_Silent_p.I813I|TACC2_ENST00000513429.1_Silent_p.I899I|TACC2_ENST00000515603.1_Silent_p.I2631I|TACC2_ENST00000515273.1_Silent_p.I2680I|TACC2_ENST00000334433.3_Silent_p.I2753I|TACC2_ENST00000369001.1_Silent_p.I380I|TACC2_ENST00000260733.3_Silent_p.I831I	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2753						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CCCTCCAGATCGCCAGAGCAG	0.547000													19	13					0	0	0.00229938	0	0
RAB3GAP1	22930	broad.mit.edu	37	2	135884211	135884211	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr2:135884211C>T	ENST00000264158.8	+	11	1001	c.958C>T	c.(958-960)Cct>Tct	p.P320S	RAB3GAP1_ENST00000442034.1_Missense_Mutation_p.P320S|RAB3GAP1_ENST00000539493.1_Missense_Mutation_p.P276S|RAB3GAP1_ENST00000487003.1_3'UTR	NM_012233.2	NP_036365.1	Q15042	RB3GP_HUMAN	RAB3 GTPase activating protein subunit 1 (catalytic)	320						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32				BRCA - Breast invasive adenocarcinoma(221;0.117)		AGCTGAGAATCCTCAGTGTTT	0.358000													84	97					0	0	0.000781405	0	0
EMC3-AS1	442075	broad.mit.edu	37	3	10035779	10035783	+	RNA	DEL	AGTCT	AGTCT	-	rs35714562		TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr3:10035779_10035783delAGTCT	ENST00000326237.3	+	0	354																											GGGGAAGAGAAGTCTGATCTGACAT	0.380													8	42	---	---	---	---					
UBA5	79876	broad.mit.edu	37	3	132379489	132379489	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr3:132379489delC	ENST00000356232.4	+	1	1180	c.108delC	c.(106-108)ggfs	p.G36fs	UBA5_ENST00000473651.1_Frame_Shift_Del_p.G36fs|ACAD11_ENST00000264990.6_5'UTR|UBA5_ENST00000493720.2_Frame_Shift_Del_p.G36fs|UBA5_ENST00000494238.2_5'UTR|UBA5_ENST00000264991.4_Intron|UBA5_ENST00000480955.1_3'UTR	NM_024818.3	NP_079094.1	Q9GZZ9	UBA5_HUMAN	ubiquitin-like modifier activating enzyme 5	36					protein ufmylation	aggresome|cytoplasm|nucleus	ATP binding|cofactor binding|metal ion binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding|UFM1 activating enzyme activity			breast(2)|endometrium(4)|kidney(4)|large_intestine(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16						GAGGGGGCGGCCGGGTCCGCA	0.682													2	4	---	---	---	---					
PPARGC1B	133522	broad.mit.edu	37	5	149216399	149216400	+	In_Frame_Ins	INS	-	-	CAG			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr5:149216399_149216400insCAG	ENST00000309241.5	+	8	2413_2414	c.2381_2382insCAG	c.(2380-2382)gag>gCAGag	p.793_794insA	PPARGC1B_ENST00000403750.1_In_Frame_Ins_p.729_730insA|PPARGC1B_ENST00000394320.3_In_Frame_Ins_p.793_794insA|PPARGC1B_ENST00000360453.4_In_Frame_Ins_p.754_755insA	NM_133263.3	NP_573570.3	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	793	Glu-rich.				estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(2)|lung(15)|ovary(3)|prostate(2)|stomach(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			GTCTTTGAAGACAGCAGCAGCA	0.599													53	47	---	---	---	---					
CNTNAP3B	728577	broad.mit.edu	37	9	43844265	43844265	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr9:43844265delG	ENST00000377564.3	+	10	1992	c.1599delG	c.(1597-1599)gcfs	p.A533fs		NM_001201380.1	NP_001188309.1	Q96NU0	CNT3B_HUMAN	contactin associated protein-like 3B	533	Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			central_nervous_system(1)|endometrium(2)|lung(3)|pancreas(1)|prostate(3)	10						AGCAGGGGGCGCTGGGGAGTT	0.542													4	3	---	---	---	---					
ARID2	196528	broad.mit.edu	37	12	46285865	46285891	+	Splice_Site	DEL	GAAGTCTTCTACCAAGTAAGGAAAATG	GAAGTCTTCTACCAAGTAAGGAAAATG	-	rs150531382		TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr12:46285865_46285891delGAAGTCTTCTACCAAGTAAGGAAAATG	ENST00000334344.6	+	18	5305_5319	c.5147_splice	c.e18+1	p.Q1712_splice	ARID2_ENST00000479608.1_3'UTR|ARID2_ENST00000422737.1_Splice_Site_p.Q1563_splice|ARID2_ENST00000444670.1_Splice_Site_p.Q1322_splice|ARID2_ENST00000457135.1_Splice_Site_p.Q320_splice	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1712					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		CAGGAAGTCAGAAGTCTTCTACCAAGTAAGGAAAATGAGTTTACTTC	0.396			"""N, S, F"""		hepatocellular carcinoma								4	6	---	---	---	---					
SLTM	79811	broad.mit.edu	37	15	59182564	59182565	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr15:59182564_59182565delCT	ENST00000380516.2	-	15	2081_2082	c.1994_1995delAG	c.(1993-1995)gfs	p.E665fs	SLTM_ENST00000536328.1_Frame_Shift_Del_p.E234fs|AC025918.2_ENST00000452467.1_RNA	NM_001013843.1|NM_024755.2	NP_001013865.1|NP_079031.2	Q9NWH9	SLTM_HUMAN	SAFB-like, transcription modulator	665	Arg/Glu-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TTTCTAGGCGCTCTCTCTCTCT	0.475													7	149	---	---	---	---					
CHD2	1106	broad.mit.edu	37	15	93444495	93444497	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr15:93444495_93444497delGAG	ENST00000394196.4	+	2	1096_1098	c.28_30delGAG	c.(28-30)del	p.E11del	CHD2_ENST00000420239.2_In_Frame_Del_p.E11del|CHD2_ENST00000557381.1_In_Frame_Del_p.E11del	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	11					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			CAAAAGCCAAGAGGAGGACAGTT	0.399													11	10	---	---	---	---					
FBXW10	10517	broad.mit.edu	37	17	18653309	18653310	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr17:18653309_18653310insT	ENST00000308799.4	+	3	1164_1165	c.945_946insT	c.(943-948)atttttfs	p.IF315fs	FBXW10_ENST00000301938.4_Intron|FBXW10_ENST00000395665.4_Intron|FBXW10_ENST00000395667.1_Intron			Q5XX13	FBW10_HUMAN	F-box and WD repeat domain containing 10	293	F-box.									NS(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42						CTGGGTCCATCTTTTTTTTTCC	0.535													9	148	---	---	---	---					
SRP68	6730	broad.mit.edu	37	17	74041436	74041436	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr17:74041436delA	ENST00000307877.2	-	12	1492	c.1331delT	c.(1330-1332)tafs	p.L444fs	SRP68_ENST00000602720.1_Frame_Shift_Del_p.L105fs|SRP68_ENST00000539137.1_Frame_Shift_Del_p.L406fs|SRP68_ENST00000355113.5_Frame_Shift_Del_p.L343fs|SRP68_ENST00000542536.2_5'UTR	NM_014230.3	NP_055045.2	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	444					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			NS(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(5)|lung(4)|ovary(2)|prostate(3)	23						GTCTTCCTCTAAACCAGGAAG	0.448													66	101	---	---	---	---					
DNMT1	1786	broad.mit.edu	37	19	10262139	10262139	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:10262139delT	ENST00000340748.4	-	23	2387	c.2152delA	c.(2152-2154)tgfs	p.M718fs	DNMT1_ENST00000540357.1_Frame_Shift_Del_p.M718fs|DNMT1_ENST00000359526.4_Frame_Shift_Del_p.M734fs			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	718					chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	CCCTGGTGCATTTTTTTGGGT	0.507													8	255	---	---	---	---					
GLTSCR1	29998	broad.mit.edu	37	19	48185390	48185390	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr19:48185390delC	ENST00000396720.3	+	7	2458	c.2264delC	c.(2263-2265)tcfs	p.S755fs	CTD-2571L23.8_ENST00000599924.1_lincRNA	NM_015711.3	NP_056526.3	Q9NZM4	GSCR1_HUMAN	glioma tumor suppressor candidate region gene 1	755							protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|pancreas(3)|prostate(4)|skin(2)	20		all_cancers(25;1.8e-07)|all_lung(116;5.73e-06)|Lung NSC(112;9.69e-06)|all_epithelial(76;2.42e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000358)|OV - Ovarian serous cystadenocarcinoma(262;0.000576)|Epithelial(262;0.0212)|GBM - Glioblastoma multiforme(486;0.0355)		AGCCAGGCTTCCCCGGCTCCG	0.741													2	4	---	---	---	---					
UMODL1	89766	broad.mit.edu	37	21	43531807	43531808	+	Frame_Shift_Ins	INS	-	-	C	rs220130	by1000genomes	TCGA-FS-A1ZD-06A-11D-A197-08	TCGA-FS-A1ZD-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ea666b7-2b6e-4df8-9a9d-b8265b9749b4	de373850-b2ca-457e-a345-c7634a1dd4fa	g.chr21:43531807_43531808insC	ENST00000400427.1	+	11	2655_2656	c.2259_2260insC	c.(2257-2262)aaccccfs	p.NP753fs	UMODL1_ENST00000408989.2_Frame_Shift_Ins_p.NP825fs|UMODL1_ENST00000400424.1_Frame_Shift_Ins_p.NP625fs|UMODL1_ENST00000408910.2_Frame_Shift_Ins_p.NP697fs	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1	741	Fibronectin type-III 2.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						CAGCTCTGAAGACCCCCGCCTG	0.589													7	11	---	---	---	---