Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
POGZ	23126	broad.mit.edu	37	1	151396447	151396447	+	Missense_Mutation	SNP	T	T	G			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr1:151396447T>G	ENST00000271715.2	-	9	1815	c.1501A>C	c.(1501-1503)Aaa>Caa	p.K501Q	POGZ_ENST00000409503.1_Missense_Mutation_p.K492Q|POGZ_ENST00000491586.1_Missense_Mutation_p.K448Q|POGZ_ENST00000392723.1_Missense_Mutation_p.K448Q|POGZ_ENST00000540984.1_Intron|POGZ_ENST00000361398.3_Missense_Mutation_p.K448Q|POGZ_ENST00000531094.1_Missense_Mutation_p.K439Q|POGZ_ENST00000368863.2_Missense_Mutation_p.K406Q	NM_001194937.1|NM_015100.3	NP_001181866.1|NP_055915.2	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	501					cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(10)|kidney(3)|large_intestine(10)|liver(2)|lung(11)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	47	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TTTAGCCTTTTGGTACAATGT	0.398000													21	100					0	0	0.014323	0	0
HJURP	55355	broad.mit.edu	37	2	234750609	234750609	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr2:234750609G>A	ENST00000411486.2	-	8	882	c.817C>T	c.(817-819)Cgg>Tgg	p.R273W	HJURP_ENST00000434039.1_5'UTR|HJURP_ENST00000441687.1_Missense_Mutation_p.R188W|HJURP_ENST00000432087.1_Missense_Mutation_p.R219W	NM_018410.3	NP_060880.3	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	273					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			NS(2)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(2)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		CTCAACAGCCGGCTCATGGAG	0.493000													91	34					0	0	0.014410	0	0
IGF2R	3482	broad.mit.edu	37	6	160501173	160501173	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr6:160501173G>A	ENST00000356956.1	+	39	5847	c.5699G>A	c.(5698-5700)gGc>gAc	p.G1900D		NM_000876.2	NP_000867.2	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	1900	Fibronectin type-II.				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		ACCGATGACGGCGTCCCCTGT	0.532000													35	105					0	0	0.004289	0	0
ALDH18A1	5832	broad.mit.edu	37	10	97393334	97393334	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr10:97393334G>A	ENST00000371224.2	-	6	768	c.631C>T	c.(631-633)Ctt>Ttt	p.L211F	ALDH18A1_ENST00000371221.3_Missense_Mutation_p.L211F	NM_002860.3	NP_002851.2	P54886	P5CS_HUMAN	aldehyde dehydrogenase 18 family, member A1	211	Glutamate 5-kinase.				proline biosynthetic process	mitochondrial inner membrane	ATP binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(9)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Colorectal(252;0.0402)		Epithelial(162;9.1e-07)|all cancers(201;2.55e-05)	L-Glutamic Acid(DB00142)	TTCATTCTAAGGAGTTCATGA	0.438000													38	77					0	0	0.005524	0	0
C1orf198	84886	broad.mit.edu	37	1	230979330	230979330	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr1:230979330G>A	ENST00000366663.5	-	3	837	c.697C>T	c.(697-699)Cct>Tct	p.P233S	C1orf198_ENST00000427697.2_Missense_Mutation_p.P16S|C1orf198_ENST00000523410.1_Missense_Mutation_p.P103S|C1orf198_ENST00000470540.1_Missense_Mutation_p.P195S	NM_032800.2	NP_116189.1	Q9H425	CA198_HUMAN	chromosome 1 open reading frame 198	233										breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	17	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				TTCGGGGCAGGTTCCTGCCGG	0.637000													19	101					0	0	0.010504	0	0
CYP2B7P	1556	broad.mit.edu	37	19	41454981	41454981	+	RNA	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr19:41454981G>A	ENST00000599198.1	+	0	1372					NR_001278.1															NS(1)|endometrium(6)|kidney(1)|lung(2)|ovary(1)|skin(1)	12						TCTTGGTGAAGGCATTGCCCG	0.577000													5	36					0	0	0.001168	0	0
BAIAP3	8938	broad.mit.edu	37	16	1392990	1392990	+	Missense_Mutation	SNP	A	A	G			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr16:1392990A>G	ENST00000324385.5	+	14	1501	c.1343A>G	c.(1342-1344)aAc>aGc	p.N448S	BAIAP3_ENST00000421665.2_Missense_Mutation_p.N377S|BAIAP3_ENST00000568887.1_Missense_Mutation_p.N385S|BAIAP3_ENST00000397489.1_Missense_Mutation_p.N430S|BAIAP3_ENST00000426824.3_Missense_Mutation_p.N413S|BAIAP3_ENST00000397488.2_Missense_Mutation_p.N430S|BAIAP3_ENST00000562208.1_Missense_Mutation_p.N390S	NM_003933.4	NP_003924.2	O94812	BAIP3_HUMAN	BAI1-associated protein 3	448					G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(25)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42		Hepatocellular(780;0.0893)				GCCCAGAGCAACCTGTCACCC	0.687000													23	45					0	0	0.004656	0	0
CCDC88B	283234	broad.mit.edu	37	11	64112234	64112234	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr11:64112234G>A	ENST00000356786.5	+	14	2265	c.2221G>A	c.(2221-2223)Gct>Act	p.A741T	CCDC88B_ENST00000463837.1_3'UTR|CCDC88B_ENST00000301897.4_De_novo_Start_InFrame	NM_032251.5	NP_115627.6	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B	741					microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GAGGAGAAAGGCTGAGGCCCT	0.662000													23	23					0	0	0.014323	0	0
AKAP4	8852	broad.mit.edu	37	X	49958737	49958737	+	Missense_Mutation	SNP	A	A	C			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chrX:49958737A>C	ENST00000376056.2	-	5	750	c.600T>G	c.(598-600)gaT>gaG	p.D200E	AKAP4_ENST00000481402.1_5'UTR|AKAP4_ENST00000358526.2_Missense_Mutation_p.D209E|AKAP4_ENST00000376058.2_Intron|AKAP4_ENST00000376064.3_Missense_Mutation_p.D200E			Q5JQC9	AKAP4_HUMAN	A kinase (PRKA) anchor protein 4	209					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(6)|lung(14)|ovary(1)|skin(4)	41	Ovarian(276;0.236)					AACATTCTCCATCAGGGGAAA	0.443000													150	58					0	0	0.014410	0	0
TADA3	10474	broad.mit.edu	37	3	9831606	9831606	+	Silent	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr3:9831606G>A	ENST00000343450.2	-	3	796	c.249C>T	c.(247-249)ttC>ttT	p.F83F	TADA3_ENST00000301964.2_Silent_p.F83F|TADA3_ENST00000440161.1_Silent_p.F83F|TADA3_ENST00000492635.1_5'UTR	NM_133480.1	NP_597814.1	O75528	TADA3_HUMAN	transcriptional adaptor 3	83					estrogen receptor signaling pathway|histone H3 acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	ligand-dependent nuclear receptor binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	16						CCAGCTTCAGGAATCGTCTGT	0.522000													43	20					0	0	0.013114	0	0
MYO1A	4640	broad.mit.edu	37	12	57424845	57424845	+	Silent	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr12:57424845C>T	ENST00000442789.2	-	24	2750	c.2463G>A	c.(2461-2463)caG>caA	p.Q821Q	MYO1A_ENST00000544473.1_Silent_p.Q659Q|MYO1A_ENST00000300119.3_Silent_p.Q821Q	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	821					sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						AGAAGAGCTGCTGCAGCTCCT	0.532000													37	49					0	0	0.006230	0	0
PPP1R3D	5509	broad.mit.edu	37	20	58514314	58514314	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr20:58514314C>T	ENST00000370996.3	-	1	1038	c.673G>A	c.(673-675)Ggg>Agg	p.G225R	FAM217B_ENST00000358293.3_Intron	NM_006242.3	NP_006233.1	O95685	PPR3D_HUMAN	protein phosphatase 1, regulatory subunit 3D	225	CBM21.				glycogen metabolic process		protein binding|protein serine/threonine phosphatase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|urinary_tract(1)	13	all_lung(29;0.00391)		BRCA - Breast invasive adenocarcinoma(7;5.12e-09)			CCTGCGGGCCCGCGCCACCGC	0.692000													13	60					0	0	0.003163	0	0
ZNF845	91664	broad.mit.edu	37	19	53856702	53856702	+	Missense_Mutation	SNP	G	G	A	rs150688663	by1000genomes	TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr19:53856702G>A	ENST00000458035.1	+	4	2891	c.2774G>A	c.(2773-2775)cGt>cAt	p.R925H	ZNF845_ENST00000595091.1_Missense_Mutation_p.R925H	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	925					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R925H(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						AAAACCTTCCGTCACAATTCA	0.363000													3	37					0	0	0.009096	0	0
KRTAP4-7	100132476	broad.mit.edu	37	17	39240661	39240661	+	Missense_Mutation	SNP	C	C	G	rs11650484	by1000genomes	TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr17:39240661C>G	ENST00000391417.4	+	1	203	c.203C>G	c.(202-204)aCc>aGc	p.T68S		NM_033061.3	NP_149050.3			keratin associated protein 4-7											NS(1)|endometrium(3)|kidney(1)|lung(1)|prostate(2)|urinary_tract(1)	9						TGTCGCCCCACCTGCTGTGAG	0.657000													5	64					0	0	0.008291	0	0
TRPM2	7226	broad.mit.edu	37	21	45802618	45802618	+	Silent	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr21:45802618G>A	ENST00000397928.1	+	9	1678	c.1233G>A	c.(1231-1233)cgG>cgA	p.R411R	TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300481.9_Silent_p.R411R|TRPM2_ENST00000300482.5_Silent_p.R411R|TRPM2_ENST00000397932.2_Silent_p.R411R	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	411						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						ATATCGTCCGGAGGCGGCAGC	0.562000													16	19					0	0	0.004007	0	0
RERE	473	broad.mit.edu	37	1	8420556	8420556	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr1:8420556G>A	ENST00000337907.3	-	19	3645	c.3011C>T	c.(3010-3012)cCc>cTc	p.P1004L	RERE_ENST00000476556.1_Missense_Mutation_p.P450L|RERE_ENST00000400907.2_Intron|RERE_ENST00000400908.2_Missense_Mutation_p.P1004L|RERE_ENST00000377464.1_Missense_Mutation_p.P736L	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	1004	Pro-rich.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		CAGCCCGGGGGGCTGGGCGGG	0.721000													10	3					0	0	0.006214	0	0
KRTAP4-7	100132476	broad.mit.edu	37	17	39240627	39240627	+	Missense_Mutation	SNP	T	T	C	rs139671425	by1000genomes	TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr17:39240627T>C	ENST00000391417.4	+	1	169	c.169T>C	c.(169-171)Tct>Cct	p.S57P		NM_033061.3	NP_149050.3			keratin associated protein 4-7									p.S57P(4)		NS(1)|endometrium(3)|kidney(1)|lung(1)|prostate(2)|urinary_tract(1)	9						GTGCTGCCAGTCTGTGTGCTG	0.667000													6	77					0	0	0.013537	0	0
SCAI	286205	broad.mit.edu	37	9	127762264	127762264	+	Missense_Mutation	SNP	A	A	G			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr9:127762264A>G	ENST00000336505.5	-	13	1208	c.1150T>C	c.(1150-1152)Tat>Cat	p.Y384H	SCAI_ENST00000487795.1_5'UTR|SCAI_ENST00000373549.4_Missense_Mutation_p.Y407H	NM_001144877.2	NP_001138349.1	Q8N9R8	SCAI_HUMAN	suppressor of cancer cell invasion	384					negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|integral to membrane|nucleus	protein binding|transcription corepressor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(7)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|prostate(5)|stomach(1)|urinary_tract(1)	35						CCAAAATCATAAGGACCTATA	0.378000													31	139					0	0	0.010818	0	0
OR10R2	343406	broad.mit.edu	37	1	158449791	158449791	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr1:158449791G>A	ENST00000368152.1	+	1	124	c.124G>A	c.(124-126)Gaa>Aaa	p.E42K	RP11-144L1.4_ENST00000426251.1_RNA|RP11-144L1.4_ENST00000419738.1_RNA	NM_001004472.1	NP_001004472.1	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R, member 2	42					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(26)|pancreas(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	41	all_hematologic(112;0.0378)					CAGCCTTGGTGAAATTCAGCT	0.423000													67	107					0	0	0.014410	0	0
PGC	5225	broad.mit.edu	37	6	41712139	41712139	+	Silent	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr6:41712139G>A	ENST00000373025.3	-	3	386	c.324C>T	c.(322-324)gcC>gcT	p.A108A	PGC_ENST00000425343.2_Silent_p.A108A	NM_002630.3	NP_002621.1	P20142	PEPC_HUMAN	progastricsin (pepsinogen C)	108					digestion|proteolysis	extracellular space	aspartic-type endopeptidase activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|skin(1)	16	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;0.000132)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			ACTCACTGCAGGCCTGGCTCT	0.612000													71	70					0	0	0.014410	0	0
PDGFRL	5157	broad.mit.edu	37	8	17447069	17447069	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr8:17447069C>T	ENST00000541323.1	+	3	593	c.148C>T	c.(148-150)Cct>Tct	p.P50S	PDGFRL_ENST00000398074.3_Missense_Mutation_p.P50S|PDGFRL_ENST00000251630.6_Missense_Mutation_p.P50S	NM_006207.2	NP_006198.1	Q15198	PGFRL_HUMAN	platelet-derived growth factor receptor-like	50						extracellular region	platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(5)	9				Colorectal(111;0.0752)		GCCCAAAATTCCTAAAATGAA	0.468000													114	34					0	0	0.014410	0	0
TNC	3371	broad.mit.edu	37	9	117848377	117848377	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr9:117848377C>T	ENST00000350763.4	-	3	2044	c.1633G>A	c.(1633-1635)Ggg>Agg	p.G545R	TNC_ENST00000341037.4_Missense_Mutation_p.G545R|TNC_ENST00000542877.1_Missense_Mutation_p.G545R|TNC_ENST00000340094.3_Missense_Mutation_p.G545R|TNC_ENST00000345230.3_Missense_Mutation_p.G545R|TNC_ENST00000535648.1_Missense_Mutation_p.G545R|TNC_ENST00000537320.1_Missense_Mutation_p.G545R|TNC_ENST00000346706.3_Missense_Mutation_p.G545R|TNC_ENST00000423613.2_Missense_Mutation_p.G545R	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	545	EGF-like 13.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						ACGCACTGCCCATTCACACAG	0.592000													21	42					0	0	0.010504	0	0
FOSL2	2355	broad.mit.edu	37	2	28627176	28627176	+	Missense_Mutation	SNP	T	T	G			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr2:28627176T>G	ENST00000264716.4	+	2	1168	c.305T>G	c.(304-306)gTg>gGg	p.V102G	FOSL2_ENST00000460736.1_3'UTR|FOSL2_ENST00000379619.1_Missense_Mutation_p.V77G|FOSL2_ENST00000545753.1_Missense_Mutation_p.V63G	NM_005253.3	NP_005244.1	P15408	FOSL2_HUMAN	FOS-like antigen 2	102					cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(1)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	14	Acute lymphoblastic leukemia(172;0.155)					AGACCTGGCGTGATCAAGACC	0.637000													35	136					0	0	0.006230	0	0
ACAD10	80724	broad.mit.edu	37	12	112182552	112182552	+	Missense_Mutation	SNP	A	A	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr12:112182552A>T	ENST00000455480.2	+	14	2090	c.1913A>T	c.(1912-1914)gAg>gTg	p.E638V	ACAD10_ENST00000413681.3_3'UTR|ACAD10_ENST00000392636.2_Missense_Mutation_p.E209V|ACAD10_ENST00000313698.4_Missense_Mutation_p.E607V|ACAD10_ENST00000549590.1_Missense_Mutation_p.E607V	NM_001136538.1	NP_001130010.1	Q6JQN1	ACD10_HUMAN	acyl-CoA dehydrogenase family, member 10	607							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(17)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(5)	47						GTTTTCAAAGAGATGCCCTTC	0.537000													19	50					0	0	0.007413	0	0
ARHGEF15	22899	broad.mit.edu	37	17	8215734	8215734	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr17:8215734C>A	ENST00000361926.3	+	2	487	c.377C>A	c.(376-378)tCa>tAa	p.S126*	ARHGEF15_ENST00000421050.1_Nonsense_Mutation_p.S126*	NM_173728.3	NP_776089.2	O94989	ARHGF_HUMAN	Rho guanine nucleotide exchange factor (GEF) 15	126	Pro-rich.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(9)|large_intestine(5)|lung(11)|ovary(5)|prostate(3)|skin(2)|urinary_tract(1)	37						CCGTCTGGGTCACCCTGCACG	0.672000													21	184					8.10497e-08	9.39223e-08	0.010504	1	0
NYAP1	222950	broad.mit.edu	37	7	100086290	100086290	+	Missense_Mutation	SNP	A	A	G			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr7:100086290A>G	ENST00000423930.1	+	4	1105	c.946A>G	c.(946-948)Acc>Gcc	p.T316A	NYAP1_ENST00000300179.2_Missense_Mutation_p.T316A|NYAP1_ENST00000454988.1_Missense_Mutation_p.T259A			Q6ZVC0	CG051_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1	316	Pro-rich.																CGGGACGCCCACCAAGACCAC	0.672000													28	146					0	0	0.012213	0	0
ZRSR1	7310	broad.mit.edu	37	5	112227799	112227799	+	Missense_Mutation	SNP	A	A	G	rs712665	by1000genomes	TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr5:112227799A>G	ENST00000391338.1	+	1	487	c.463A>G	c.(463-465)Agt>Ggt	p.S155G	REEP5_ENST00000379638.4_Intron|REEP5_ENST00000474542.2_Intron|REEP5_ENST00000513339.1_Intron|REEP5_ENST00000545426.1_Intron|REEP5_ENST00000504247.1_Intron|SRP19_ENST00000512790.1_3'UTR	NM_001204199.1	NP_001191128.1			zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1											breast(1)|skin(1)|stomach(2)	4						TTTAGAAAATAGTACCACATG	0.433000													4	56					0	0	0.000602	0	0
ELAVL2	1993	broad.mit.edu	37	9	23692762	23692762	+	Silent	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr9:23692762G>A	ENST00000397312.2	-	7	1147	c.873C>T	c.(871-873)atC>atT	p.I291I	ELAVL2_ENST00000380110.4_Silent_p.I321I|ELAVL2_ENST00000223951.6_Silent_p.I278I|ELAVL2_ENST00000380117.1_Silent_p.I291I|ELAVL2_ENST00000544538.1_Silent_p.I291I	NM_004432.3	NP_004423.2	Q12926	ELAV2_HUMAN	ELAV like neuron-specific RNA binding protein 2	291	RRM 3.				regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		TTTGCCACAGGATACTCTCAT	0.458000													67	23					0	0	0.014410	0	0
PABPC1	26986	broad.mit.edu	37	8	101717163	101717163	+	Silent	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr8:101717163G>A	ENST00000318607.5	-	13	2937	c.1809C>T	c.(1807-1809)ctC>ctT	p.L603L	PABPC1_ENST00000519004.1_Silent_p.L558L|PABPC1_ENST00000522387.1_Silent_p.L571L	NM_002568.3	NP_002559.2	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	603	PABC.				mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity			breast(2)|endometrium(4)|kidney(15)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	40	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			CCTTAGAACGGAGTGACTCTG	0.393000													54	90					0	0	0.014410	0	0
FBRS	64319	broad.mit.edu	37	16	30680186	30680186	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr16:30680186C>T	ENST00000356166.6	+	17	3340	c.2252C>T	c.(2251-2253)cCt>cTt	p.P751L	FBRS_ENST00000395073.2_Missense_Mutation_p.P143L|FBRS_ENST00000287468.5_Missense_Mutation_p.P231L|FBRS_ENST00000568722.1_Missense_Mutation_p.P143L			Q9HAH7	FBRS_HUMAN	fibrosin	231										ovary(1)	1			Colorectal(24;0.103)			CACCGCAGTCCTCTGACCTTT	0.701000													11	12					0	0	0.010729	0	0
TRPM6	140803	broad.mit.edu	37	9	77370293	77370293	+	Missense_Mutation	SNP	T	T	C			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr9:77370293T>C	ENST00000451710.3	-	28	5119	c.4882A>G	c.(4882-4884)Aca>Gca	p.T1628A	TRPM6_ENST00000449912.2_Missense_Mutation_p.T1623A|TRPM6_ENST00000376864.4_Missense_Mutation_p.T1628A|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000361255.3_Missense_Mutation_p.T1623A|TRPM6_ENST00000360774.1_Missense_Mutation_p.T1628A|TRPM6_ENST00000376872.3_Missense_Mutation_p.T579A			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1628					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TTGGACACTGTGAACCAGTTC	0.458000													30	126					0	0	0.012213	0	0
PPARGC1B	133522	broad.mit.edu	37	5	149206305	149206305	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr5:149206305G>A	ENST00000309241.5	+	3	354	c.322G>A	c.(322-324)Gtg>Atg	p.V108M	PPARGC1B_ENST00000360453.4_Missense_Mutation_p.V108M|PPARGC1B_ENST00000394320.3_Missense_Mutation_p.V108M|PPARGC1B_ENST00000403750.1_Missense_Mutation_p.V83M	NM_133263.3	NP_573570.3	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	108					estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(2)|lung(15)|ovary(3)|prostate(2)|stomach(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TGAAGATGACGTGGGTCTGGC	0.622000													38	41					0	0	0.004878	0	0
NKX2-3	159296	broad.mit.edu	37	10	101293025	101293025	+	Missense_Mutation	SNP	T	T	G			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr10:101293025T>G	ENST00000344586.7	+	1	336	c.137T>G	c.(136-138)aTg>aGg	p.M46R		NM_145285.2	NP_660328.2	Q8TAU0	NKX23_HUMAN	NK2 homeobox 3	46						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	5		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.45e-08)		GCGCCCTGCATGCTGGCCGCC	0.572000													7	30					0	0	0.003080	0	0
SUGP2	10147	broad.mit.edu	37	19	19121075	19121075	+	Missense_Mutation	SNP	T	T	C			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr19:19121075T>C	ENST00000601879.1	-	5	2224	c.1927A>G	c.(1927-1929)Aac>Gac	p.N643D	SUGP2_ENST00000452918.2_Missense_Mutation_p.N643D|SUGP2_ENST00000337018.6_Missense_Mutation_p.N643D|SUGP2_ENST00000600377.1_Missense_Mutation_p.N657D|SUGP2_ENST00000456085.2_Missense_Mutation_p.N412D			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	643					mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						CCTCGCAAGTTCTCGCTCATC	0.488000													62	283					0	0	0.014410	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994526	140994526	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chrX:140994526C>T	ENST00000285879.4	+	4	1622	c.1336C>T	c.(1336-1338)Cct>Tct	p.P446S	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	446							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TCTCCAGATTCCTGTGAGCTC	0.463000										HNSCC(15;0.026)			139	140					0	0	0.014410	0	0
PSG1	5669	broad.mit.edu	37	19	43372258	43372258	+	Missense_Mutation	SNP	A	A	G			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr19:43372258A>G	ENST00000244296.2	-	5	1375	c.1238T>C	c.(1237-1239)gTc>gCc	p.V413A	PSG1_ENST00000595356.1_Missense_Mutation_p.V413A|PSG1_ENST00000312439.6_Missense_Mutation_p.V413A|PSG1_ENST00000436291.2_Missense_Mutation_p.V413A|PSG1_ENST00000403380.3_Missense_Mutation_p.V320A|PSG1_ENST00000595124.1_Missense_Mutation_p.V320A	NM_006905.2	NP_008836.2			pregnancy specific beta-1-glycoprotein 1											breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30		Prostate(69;0.00682)				CTTACCAGAGACTTCGACTGT	0.463000													98	336					0	0	0.014410	0	0
PCDHGA11	56105	broad.mit.edu	37	5	140801461	140801461	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr5:140801461C>T	ENST00000398587.2	+	1	700	c.667C>T	c.(667-669)Cga>Tga	p.R223*	PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA11_ENST00000518882.1_Nonsense_Mutation_p.R223*|PCDHGA4_ENST00000571252.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB6_ENST00000520790.1_Intron	NM_018914.2|NM_032092.1	NP_061737.1|NP_114481.1														breast(3)|endometrium(8)|kidney(3)|large_intestine(9)|lung(22)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGATCCCATCCGAAAGGGCGC	0.522000													44	24					0	0	0.008740	0	0
S100A7L2	645922	broad.mit.edu	37	1	153410686	153410686	+	Silent	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr1:153410686G>A	ENST00000368725.2	-	2	152	c.153C>T	c.(151-153)ttC>ttT	p.F51F		NM_001045479.1	NP_001038944.2			S100 calcium binding protein A7-like 2											NS(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	8	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGAAGTTGGGGAAGTTCTCCT	0.507000													25	49					0	0	0.007291	0	0
IMP4	92856	broad.mit.edu	37	2	131103834	131103834	+	Silent	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr2:131103834C>T	ENST00000259239.3	+	8	1458	c.750C>T	c.(748-750)cgC>cgT	p.R250R	IMP4_ENST00000409935.1_Intron	NM_033416.1	NP_219484.1	Q96G21	IMP4_HUMAN	IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)	250	Brix.				rRNA processing|translation	nucleolus|ribonucleoprotein complex	aminoacyl-tRNA ligase activity|ATP binding|protein binding			central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|skin(1)|urinary_tract(1)	18	Colorectal(110;0.1)					TCGGGCCCCGCTTTGAGCTGA	0.617000													13	32					0	0	0.003163	0	0
PLEKHA8	84725	broad.mit.edu	37	7	30094403	30094403	+	Missense_Mutation	SNP	A	A	G			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr7:30094403A>G	ENST00000449726.1	+	8	1225	c.875A>G	c.(874-876)gAc>gGc	p.D292G	PLEKHA8_ENST00000258679.7_Missense_Mutation_p.D292G|PLEKHA8_ENST00000396259.1_Missense_Mutation_p.D292G|PLEKHA8_ENST00000396257.2_Missense_Mutation_p.D292G	NM_001197027.1	NP_001183956.1	Q96JA3	PKHA8_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8	292					protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(4)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)	17						TCTGGATCAGACTCAAGTTGC	0.388000													39	123					0	0	0.006230	0	0
GUCY2D	3000	broad.mit.edu	37	17	7918671	7918671	+	Missense_Mutation	SNP	T	T	G			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr17:7918671T>G	ENST00000254854.4	+	15	2945	c.2795T>G	c.(2794-2796)aTg>aGg	p.M932R		NM_000180.3	NP_000171.1	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	932	Guanylate cyclase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				GACGCCTATATGGTGGCCTCG	0.577000													38	45					0	0	0.009718	0	0
FCRL3	115352	broad.mit.edu	37	1	157650538	157650538	+	Silent	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr1:157650538C>T	ENST00000368184.3	-	13	2271	c.1980G>A	c.(1978-1980)ccG>ccA	p.P660P	FCRL3_ENST00000368186.5_Silent_p.P660P|FCRL3_ENST00000473231.1_5'UTR	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	660			P -> L (in dbSNP:rs944627).			integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					GGGAATAAATCGGGTTGCTAT	0.413000													46	88					0	0	0.014410	0	0
FREM1	158326	broad.mit.edu	37	9	14824925	14824925	+	Silent	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr9:14824925C>T	ENST00000380881.4	-	12	2765	c.1950G>A	c.(1948-1950)cgG>cgA	p.R650R	FREM1_ENST00000380880.3_Silent_p.R649R|FREM1_ENST00000422223.2_Silent_p.R649R			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	649					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		CAACCAAATGCCGAGAAACTC	0.393000													21	16					0	0	0.012319	0	0
ZNF536	9745	broad.mit.edu	37	19	31038958	31038958	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr19:31038958C>T	ENST00000355537.3	+	4	2579	c.2432C>T	c.(2431-2433)cCg>cTg	p.P811L		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	811					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GGGGCTGGGCCGCTGTCTGGG	0.567000													64	30					0	0	0.014410	0	0
REV3L	5980	broad.mit.edu	37	6	111695074	111695074	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr6:111695074G>A	ENST00000435970.1	-	15	5066	c.4250C>T	c.(4249-4251)tCg>tTg	p.S1417L	REV3L_ENST00000368802.3_Missense_Mutation_p.S1495L|REV3L_ENST00000368805.1_Missense_Mutation_p.S1495L|REV3L_ENST00000358835.3_Missense_Mutation_p.S1495L			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	1495					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		TTCTGATAACGACCTCGGTTT	0.388000								DNA polymerases (catalytic subunits)					36	122					0	0	0.003755	0	0
DTX1	1840	broad.mit.edu	37	12	113515335	113515335	+	Missense_Mutation	SNP	T	T	G			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr12:113515335T>G	ENST00000257600.3	+	2	869	c.366T>G	c.(364-366)gaT>gaG	p.D122E		NM_004416.2	NP_004407.2	Q86Y01	DTX1_HUMAN	deltex homolog 1 (Drosophila)	122	WWE 2.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	32						CGGCCTACGATATGGACATCT	0.622000													6	68					0	0	0.001984	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664186	22664186	+	RNA	SNP	A	A	G			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr22:22664186A>G	ENST00000426066.1	+	0	709					NR_027293.1																						CAGATCAAGAAAGCACTCTGA	0.498000													5	137					0	0	0.001168	0	0
PLXNA1	5361	broad.mit.edu	37	3	126733579	126733579	+	Missense_Mutation	SNP	A	A	C			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr3:126733579A>C	ENST00000393409.2	+	13	2782	c.2782A>C	c.(2782-2784)Agc>Cgc	p.S928R	PLXNA1_ENST00000251772.4_Missense_Mutation_p.S905R	NM_032242.3	NP_115618.3	Q9UIW2	PLXA1_HUMAN	plexin A1	928	IPT/TIG 1.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		CGGGGACGCCAGCTCCGTGCG	0.706000													6	31					0	0	0.001168	0	0
VSTM1	284415	broad.mit.edu	37	19	54545555	54545555	+	Missense_Mutation	SNP	T	T	G			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr19:54545555T>G	ENST00000338372.2	-	5	638	c.463A>C	c.(463-465)Atc>Ctc	p.I155L	VSTM1_ENST00000425006.2_3'UTR|VSTM1_ENST00000376626.1_Intron|VSTM1_ENST00000366170.2_Missense_Mutation_p.I67L	NM_198481.3	NP_940883.2	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	155						integral to membrane				breast(1)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		CTGTAGATGATGAAGACTGAG	0.507000													25	32					0	0	0.003954	0	0
KDM4D	55693	broad.mit.edu	37	11	94731152	94731152	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr11:94731152C>T	ENST00000335080.5	+	3	1448	c.616C>T	c.(616-618)Ctt>Ttt	p.L206F	KDM4D_ENST00000536741.1_Missense_Mutation_p.L206F	NM_018039.2	NP_060509.2	Q6B0I6	KDM4D_HUMAN	lysine (K)-specific demethylase 4D	206	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(16)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						CTACCTGCACCTTGGGGAGCC	0.557000													70	24					0	0	0.014410	0	0
NKAIN2	154215	broad.mit.edu	37	6	125112530	125112530	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr6:125112530G>A	ENST00000368417.1	+	5	580	c.520G>A	c.(520-522)Gaa>Aaa	p.E174K	NKAIN2_ENST00000545433.1_Missense_Mutation_p.E159K|NKAIN2_ENST00000546092.1_Missense_Mutation_p.E107K	NM_001040214.1	NP_001035304.1	Q5VXU1	NKAI2_HUMAN	Na+/K+ transporting ATPase interacting 2	174						integral to membrane|plasma membrane				cervix(1)|endometrium(1)|large_intestine(3)|lung(12)|skin(2)	19				GBM - Glioblastoma multiforme(226;0.104)		ATGTATAACTGAAGAAGAGGA	0.408000													12	41					0	0	0.001855	0	0
SLC13A1	6561	broad.mit.edu	37	7	122821122	122821122	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr7:122821122C>T	ENST00000194130.2	-	2	172	c.133G>A	c.(133-135)Gcc>Acc	p.A45T	SLC13A1_ENST00000539873.1_5'UTR	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	45						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	CAAAATGTGGCGACCACAAAG	0.428000													25	81					0	0	0.005443	0	0
DSCAM	1826	broad.mit.edu	37	21	41505858	41505858	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr21:41505858C>T	ENST00000400454.1	-	19	3962	c.3485G>A	c.(3484-3486)aGc>aAc	p.S1162N		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1162	Fibronectin type-III 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CACCTGGATGCTGTAGTTGGT	0.567000													28	58					0	0	0.005443	0	0
CACNA1S	779	broad.mit.edu	37	1	201022629	201022629	+	Missense_Mutation	SNP	T	T	G			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr1:201022629T>G	ENST00000362061.3	-	30	3979	c.3753A>C	c.(3751-3753)gaA>gaC	p.E1251D	CACNA1S_ENST00000367338.3_Missense_Mutation_p.E1232D	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	1251					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TTCGCACTCCTTCTGCCCGGC	0.617000													22	81					0	0	0.003954	0	0
FIGN	55137	broad.mit.edu	37	2	164468318	164468318	+	Splice_Site	SNP	T	T	C			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr2:164468318T>C	ENST00000333129.3	-	3	340		c.e3-2		FIGN_ENST00000482917.1_Splice_Site|FIGN_ENST00000409634.1_Intron	NM_018086.2	NP_060556.2	Q5HY92	FIGN_HUMAN	fidgetin							nuclear matrix	ATP binding|nucleoside-triphosphatase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(1)|prostate(2)|skin(1)	47						TCTTCAAGCCTAAGAATTTTG	0.428000													3	43					0	0	0.004672	0	0
FAM86HP	729375	broad.mit.edu	37	3	129821754	129821754	+	RNA	SNP	C	C	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr3:129821754C>A	ENST00000500074.2	-	0	391																											CAATACAGCACGTCTACGGTG	0.587000													6	71					3.86212e-05	4.42347e-05	0.008291	1	0
PDPN	10630	broad.mit.edu	37	1	13940906	13940906	+	Splice_Site	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr1:13940906C>T	ENST00000294489.6	+	5	1051	c.710_splice	c.e5+1	p.S237_splice	PDPN_ENST00000487038.1_Splice_Site_p.S119_splice|PDPN_ENST00000475043.1_Intron|PDPN_ENST00000513143.1_Splice_Site_p.S119_splice|PDPN_ENST00000376061.4_Splice_Site_p.S119_splice|PDPN_ENST00000376057.4_Intron|PDPN_ENST00000509009.1_Splice_Site_p.S156_splice			Q86YL7	PDPN_HUMAN	podoplanin	161					cell morphogenesis|lymphangiogenesis|regulation of cell shape	filopodium membrane|integral to plasma membrane|lamellipodium membrane|microvillus membrane|ruffle membrane				endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	16	Ovarian(185;0.249)	all_lung(284;2.29e-05)|Lung NSC(185;4.37e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00969)|Colorectal(212;4.48e-06)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000347)|Kidney(185;0.00087)|KIRC - Kidney renal clear cell carcinoma(229;0.0027)|STAD - Stomach adenocarcinoma(313;0.00802)|READ - Rectum adenocarcinoma(331;0.0678)		GGAAGGTACTCGTAAGTAAAT	0.423000													49	32					0	0	0.014410	0	0
NLRP4	147945	broad.mit.edu	37	19	56363606	56363606	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr19:56363606G>A	ENST00000301295.6	+	2	582	c.160G>A	c.(160-162)Gaa>Aaa	p.E54K	NLRP4_ENST00000346986.5_Missense_Mutation_p.E54K	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	54	DAPIN.						ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		ATCCCGGGAAGAACTTGCAAA	0.403000													55	75					0	0	0.014410	0	0
EMP2	2013	broad.mit.edu	37	16	10626808	10626808	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr16:10626808G>A	ENST00000359543.3	-	5	667	c.458C>T	c.(457-459)aCc>aTc	p.T153I	EMP2_ENST00000536829.1_Missense_Mutation_p.T153I	NM_001424.4	NP_001415.1	P54851	EMP2_HUMAN	epithelial membrane protein 2	153					cell proliferation	integral to membrane				NS(1)|endometrium(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	6						GCTGATGAAGGTGCAGGCGAA	0.522000													34	76					0	0	0.003755	0	0
GUCA1C	9626	broad.mit.edu	37	3	108672598	108672598	+	Silent	SNP	G	G	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr3:108672598G>T	ENST00000261047.3	-	1	144	c.12C>A	c.(10-12)ggC>ggA	p.G4G	GUCA1C_ENST00000393963.3_Silent_p.G4G|GUCA1C_ENST00000471108.1_Silent_p.G4G	NM_005459.3	NP_005450.3	O95843	GUC1C_HUMAN	guanylate cyclase activator 1C	4					signal transduction|visual perception		calcium ion binding|calcium sensitive guanylate cyclase activator activity			endometrium(2)|large_intestine(1)|liver(1)|lung(8)|pancreas(1)|skin(1)	14						CTATAGATTTGCCATTCCCCA	0.428000													53	106					8.99859e-20	1.0679e-19	0.014410	1	0
GPR98	84059	broad.mit.edu	37	5	89939773	89939773	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr5:89939773G>A	ENST00000405460.2	+	14	2803	c.2707G>A	c.(2707-2709)Gaa>Aaa	p.E903K		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	903					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GATGATAAATGAAAGCAAAGG	0.294000													12	3					0	0	0.013537	0	0
IL10RA	3587	broad.mit.edu	37	11	117866368	117866368	+	Silent	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr11:117866368C>T	ENST00000227752.3	+	6	873	c.753C>T	c.(751-753)gcC>gcT	p.A251A	IL10RA_ENST00000533700.1_3'UTR|IL10RA_ENST00000541785.1_Silent_p.A231A|IL10RA_ENST00000545409.1_Silent_p.A102A	NM_001558.3	NP_001549.2	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha	251						integral to membrane|plasma membrane	interleukin-10 receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(2)|prostate(1)	19	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		GAGCCCTCGCCTACTGCCTGG	0.592000													44	16					0	0	0.009718	0	0
ZNF34	80778	broad.mit.edu	37	8	145999097	145999097	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr8:145999097G>A	ENST00000429371.2	-	6	1327	c.1174C>T	c.(1174-1176)Cac>Tac	p.H392Y	ZNF34_ENST00000343459.4_Missense_Mutation_p.H413Y	NM_030580.3	NP_085057.3	Q8IZ26	ZNF34_HUMAN	zinc finger protein 34	413					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(1)	11	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.221)	OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;5.18e-38)|all cancers(56;4.41e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.0179)		TCTCCAGTGTGAATTCTCTGA	0.438000													19	24					0	0	0.008871	0	0
NPHP1	4867	broad.mit.edu	37	2	110922252	110922252	+	Missense_Mutation	SNP	A	A	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr2:110922252A>T	ENST00000316534.4	-	8	857	c.784T>A	c.(784-786)Tgt>Agt	p.C262S	NPHP1_ENST00000417665.1_Intron|NPHP1_ENST00000445609.2_Intron|NPHP1_ENST00000355301.4_Intron|NPHP1_ENST00000393272.3_Missense_Mutation_p.C262S			O15259	NPHP1_HUMAN	nephronophthisis 1 (juvenile)	262					actin cytoskeleton organization|cell projection organization|cell-cell adhesion|excretion|retina development in camera-type eye|signal transduction|spermatid differentiation|visual behavior	adherens junction|cell-cell junction|cilium axoneme|cytoplasm|cytoskeleton|motile cilium|photoreceptor connecting cilium	protein binding|structural molecule activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(2)	24						TTAACAAGACAGAAGATGCCC	0.468000													39	112					0	0	0.014410	0	0
SLC17A5	26503	broad.mit.edu	37	6	74320250	74320250	+	Missense_Mutation	SNP	A	A	G			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr6:74320250A>G	ENST00000355773.5	-	9	1400	c.1132T>C	c.(1132-1134)Ttc>Ctc	p.F378L	SLC17A5_ENST00000393019.3_Intron	NM_012434.4	NP_036566.1	Q9NRA2	S17A5_HUMAN	solute carrier family 17 (acidic sugar transporter), member 5	378					anion transport	integral to plasma membrane|lysosomal membrane|membrane fraction	sialic acid:hydrogen symporter activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GCTACCAGGAATACTGCAGGT	0.383000													31	93					0	0	0.013726	0	0
FAM129A	116496	broad.mit.edu	37	1	184772734	184772734	+	Silent	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr1:184772734C>T	ENST00000367511.3	-	12	1732	c.1539G>A	c.(1537-1539)gcG>gcA	p.A513A	FAM129A_ENST00000487074.1_5'UTR	NM_052966.2	NP_443198.1	Q9BZQ8	NIBAN_HUMAN	family with sequence similarity 129, member A	513					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane		p.A513A(1)		autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						TGCATGTGGACGCCAGTGCCT	0.433000													49	87					0	0	0.014410	0	0
GOLGA2P9	440518	broad.mit.edu	37	19	22785490	22785490	+	RNA	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr19:22785490G>A	ENST00000600260.1	+	0	1579					NR_033899.1																						CAGCTCTCTGGAGAGACAGAC	0.612000													54	88					0	0	0.014410	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				42	80					0	0	0.009718	0	0
GIMAP1	170575	broad.mit.edu	37	7	150417709	150417709	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr7:150417709G>A	ENST00000307194.5	+	3	757	c.617G>A	c.(616-618)gGg>gAg	p.G206E		NM_130759.3	NP_570115.1			GTPase, IMAP family member 1									p.G206E(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CAGCTGCTGGGGATGGTCGAG	0.692000													15	15					0	0	0.002450	0	0
CPXM2	119587	broad.mit.edu	37	10	125521537	125521537	+	Missense_Mutation	SNP	G	G	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr10:125521537G>T	ENST00000241305.3	-	11	1782	c.1628C>A	c.(1627-1629)cCc>cAc	p.P543H	CPXM2_ENST00000368854.3_5'UTR	NM_198148.2	NP_937791.2	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	543					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)	47		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		GTGGTCGTCGGGGGTGGGGGT	0.672000													35	55					4.65686e-17	5.49343e-17	0.003755	1	0
ZNF274	10782	broad.mit.edu	37	19	58718389	58718389	+	Missense_Mutation	SNP	A	A	G			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr19:58718389A>G	ENST00000326804.4	+	6	1016	c.557A>G	c.(556-558)cAc>cGc	p.H186R	ZNF274_ENST00000597818.1_3'UTR|ZNF274_ENST00000424679.2_Missense_Mutation_p.H81R|ZNF274_ENST00000345813.3_Missense_Mutation_p.H154R	NM_133502.1	NP_598009.1	Q96GC6	ZN274_HUMAN	zinc finger protein 274	187	SCAN box.				viral reproduction	centrosome|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(1)|prostate(1)|skin(1)	21		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.215)		GAGCTGTGTCACCAGTGGCTA	0.627000													6	20					0	0	0.001168	0	0
OR4K1	79544	broad.mit.edu	37	14	20404268	20404268	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr14:20404268C>T	ENST00000285600.4	+	1	502	c.443C>T	c.(442-444)tCc>tTc	p.S148F		NM_001004063.2	NP_001004063.2	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K, member 1	148					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		GTGTCTATTTCCTGGGCGGTG	0.453000													15	101					0	0	0.004990	0	0
MDN1	23195	broad.mit.edu	37	6	90468045	90468045	+	Silent	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr6:90468045G>A	ENST00000369393.3	-	19	2746	c.2631C>T	c.(2629-2631)ttC>ttT	p.F877F	MDN1_ENST00000428876.1_Silent_p.F877F			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	877					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CAAATAAACGGAAGTCAGGAT	0.443000													12	9					0	0	0.013537	0	0
CCDC108	255101	broad.mit.edu	37	2	219894796	219894796	+	Silent	SNP	A	A	G			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr2:219894796A>G	ENST00000341552.5	-	10	1379	c.1296T>C	c.(1294-1296)acT>acC	p.T432T	CCDC108_ENST00000441968.1_Silent_p.T432T|CCDC108_ENST00000453220.1_Silent_p.T432T|CCDC108_ENST00000410037.1_Silent_p.T367T|CCDC108_ENST00000409865.3_Silent_p.T421T	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	432						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGGTGTCCAGAGTCTTGGGGT	0.557000											OREG0015211	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	45					0	0	0.004656	0	0
OR4L1	122742	broad.mit.edu	37	14	20528800	20528800	+	Silent	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr14:20528800C>T	ENST00000315683.1	+	1	597	c.597C>T	c.(595-597)gtC>gtT	p.V199V		NM_001004717.1	NP_001004717.1	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L, member 1	199					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(16)|ovary(2)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		AATTATTTGTCATTGCTGACA	0.423000													55	90					0	0	0.014410	0	0
C8orf34	116328	broad.mit.edu	37	8	69434077	69434077	+	Missense_Mutation	SNP	T	T	C			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr8:69434077T>C	ENST00000337103.4	+	5	2068	c.476T>C	c.(475-477)aTt>aCt	p.I159T	C8orf34_ENST00000349492.3_3'UTR|C8orf34_ENST00000348340.2_Missense_Mutation_p.I184T|C8orf34_ENST00000518698.1_Missense_Mutation_p.I270T|C8orf34_ENST00000539993.1_Missense_Mutation_p.I184T			Q49A92	CH034_HUMAN	chromosome 8 open reading frame 34	184					signal transduction		cAMP-dependent protein kinase regulator activity			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(12)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	36			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			CCCCGTGTGATTGGAGAATGG	0.403000													58	60					0	0	0.014410	0	0
TINAG	27283	broad.mit.edu	37	6	54212203	54212203	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr6:54212203C>T	ENST00000259782.4	+	6	883	c.787C>T	c.(787-789)Cga>Tga	p.R263*		NM_014464.3	NP_055279.3	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	263					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(1)	34	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			GTCTAAGGGTCGATACACGGC	0.418000													23	27					0	0	0.014323	0	0
ZNF271P	10778	broad.mit.edu	37	18	32887691	32887691	+	RNA	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr18:32887691G>A	ENST00000399070.3	+	0	2085					NR_024565.1|NR_024566.1															large_intestine(3)|lung(9)	12						GTTCAGTGCAGCAGAAGTTGT	0.428000													9	45					0	0	0.006214	0	0
OR2J2	26707	broad.mit.edu	37	6	29141738	29141738	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr6:29141738G>A	ENST00000377167.2	+	1	428	c.326G>A	c.(325-327)gGa>gAa	p.G109E		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						CTTGCACTGGGAATCACAGAG	0.488000													125	149					0	0	0.014410	0	0
FILIP1	27145	broad.mit.edu	37	6	76023848	76023848	+	Missense_Mutation	SNP	T	T	C			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr6:76023848T>C	ENST00000393004.2	-	5	1921	c.1700A>G	c.(1699-1701)aAc>aGc	p.N567S	FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000370020.1_Missense_Mutation_p.N468S|FILIP1_ENST00000237172.7_Missense_Mutation_p.N567S			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	567										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						TCTTGTCAAGTTGTATACTTT	0.313000													22	49					0	0	0.012319	0	0
MAL	4118	broad.mit.edu	37	2	95713853	95713853	+	Silent	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr2:95713853G>A	ENST00000309988.4	+	2	352	c.243G>A	c.(241-243)gaG>gaA	p.E81E	MAL_ENST00000349807.3_Intron|MAL_ENST00000354078.3_Intron|MAL_ENST00000353004.3_Silent_p.E81E	NM_002371.3	NP_002362.1	P21145	MAL_HUMAN	mal, T-cell differentiation protein	81	MARVEL.				apical protein localization|cell differentiation|central nervous system development|induction of apoptosis|membrane raft polarization|myelination	apical plasma membrane|endoplasmic reticulum|endosome|integral to plasma membrane|membrane raft	apoptotic protease activator activity|channel activity|lipid binding|structural constituent of myelin sheath	p.E81E(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|prostate(2)	10				STAD - Stomach adenocarcinoma(1183;0.18)		ACGGTGGAGAGACTTCCTGGG	0.602000													31	43					0	0	0.010818	0	0
MYH8	4626	broad.mit.edu	37	17	10307679	10307679	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr17:10307679C>T	ENST00000403437.2	-	22	2750	c.2656G>A	c.(2656-2658)Gag>Aag	p.E886K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	886					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						TCATTTTTCTCTTTTAAGAGA	0.408000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				75	48					0	0	0.014410	0	0
ALPI	248	broad.mit.edu	37	2	233321670	233321670	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr2:233321670G>A	ENST00000295463.3	+	4	439	c.362G>A	c.(361-363)gGg>gAg	p.G121E		NM_001631.3	NP_001622.2	P09923	PPBI_HUMAN	alkaline phosphatase, intestinal	121					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(2)|upper_aerodigestive_tract(1)	24		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TACCTGTGCGGGGTCAAGGCC	0.607000													16	7					0	0	0.006122	0	0
MYH13	8735	broad.mit.edu	37	17	10212567	10212567	+	Missense_Mutation	SNP	T	T	G			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr17:10212567T>G	ENST00000418404.3	-	34	5316	c.5153A>C	c.(5152-5154)cAg>cCg	p.Q1718P	MYH13_ENST00000570743.1_Missense_Mutation_p.Q1718P|MYH13_ENST00000252172.4_Missense_Mutation_p.Q1718P			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1718					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						GTGCAGGAGCTGCACGCGGTC	0.672000													15	54					0	0	0.004007	0	0
SALL2	6297	broad.mit.edu	37	14	21993455	21993455	+	Missense_Mutation	SNP	C	C	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr14:21993455C>A	ENST00000327430.3	-	2	701	c.407G>T	c.(406-408)gGa>gTa	p.G136V	SALL2_ENST00000450879.2_Intron|SALL2_ENST00000317492.5_Intron|SALL2_ENST00000538754.1_Intron	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	136	Poly-Gly.						DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		GCCCCCGCCTCCCCCAGCCGC	0.682000													26	36					1.68575e-08	1.96505e-08	0.007291	1	0
SPINK4	27290	broad.mit.edu	37	9	33246632	33246632	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr9:33246632G>A	ENST00000379725.1	+	4	312	c.190G>A	c.(190-192)Gta>Ata	p.V64I	SPINK4_ENST00000379721.3_Missense_Mutation_p.V41I|SPINK4_ENST00000379723.1_Missense_Mutation_p.V64I			O60575	ISK4_HUMAN	serine peptidase inhibitor, Kazal type 4	41	Kazal-like.					extracellular region	serine-type endopeptidase inhibitor activity			lung(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)			TGAACACATGGTAGAGTCTCC	0.557000													47	73					0	0	0.014410	0	0
DNMT3L	29947	broad.mit.edu	37	21	45671560	45671560	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr21:45671560C>T	ENST00000270172.3	-	9	1198	c.715G>A	c.(715-717)Gat>Aat	p.D239N	DNMT3L_ENST00000418993.1_Missense_Mutation_p.D239N	NM_013369.3	NP_037501.2	Q9UJW3	DNM3L_HUMAN	DNA (cytosine-5-)-methyltransferase 3-like	239					DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	11				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		TACACAAGATCGAAGGGTCCC	0.652000													30	33					0	0	0.010818	0	0
OR4K15	81127	broad.mit.edu	37	14	20443798	20443798	+	Silent	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr14:20443798C>T	ENST00000305051.5	+	1	196	c.121C>T	c.(121-123)Ctg>Ttg	p.L41L		NM_001005486.1	NP_001005486.1	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K, member 15	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|ovary(1)|prostate(2)|skin(1)|stomach(1)	39	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GTTGCTGGGACTGTCTAGTTC	0.408000													61	86					0	0	0.014410	0	0
CLDN18	51208	broad.mit.edu	37	3	137743456	137743456	+	Silent	SNP	T	T	C			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr3:137743456T>C	ENST00000183605.5	+	3	619	c.393T>C	c.(391-393)tgT>tgC	p.C131C	CLDN18_ENST00000343735.4_Silent_p.C131C	NM_016369.3	NP_057453.1	P56856	CLD18_HUMAN	claudin 18	131					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|large_intestine(2)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	6						CAGGTCTTTGTGCAATTGCTG	0.453000													45	229					0	0	0.014410	0	0
PHF21A	51317	broad.mit.edu	37	11	45991416	45991416	+	Missense_Mutation	SNP	G	G	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr11:45991416G>T	ENST00000257821.4	-	8	1275	c.652C>A	c.(652-654)Cag>Aag	p.Q218K	PHF21A_ENST00000418153.2_Missense_Mutation_p.Q217K|PHF21A_ENST00000323180.6_Missense_Mutation_p.Q218K	NM_001101802.1	NP_001095272.1	Q96BD5	PF21A_HUMAN	PHD finger protein 21A	217					blood coagulation|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(10)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	29						GGGATAAACTGTGGTACTTTG	0.423000													6	17					2.0095e-06	2.31504e-06	0.001984	1	0
ARGFX	503582	broad.mit.edu	37	3	121305296	121305296	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr3:121305296C>T	ENST00000334384.3	+	4	807	c.797C>T	c.(796-798)tCc>tTc	p.S266F		NM_001012659.1	NP_001012677.1	A6NJG6	ARGFX_HUMAN	arginine-fifty homeobox	266						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	15				GBM - Glioblastoma multiforme(114;0.152)		GGACAGGGTTCCTCTCTCAGC	0.478000													47	70					0	0	0.011902	0	0
ZNF493	284443	broad.mit.edu	37	19	21606712	21606712	+	Silent	SNP	T	T	C			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr19:21606712T>C	ENST00000392288.2	+	4	1360	c.1251T>C	c.(1249-1251)tcT>tcC	p.S417S	CTD-2561J22.3_ENST00000600810.1_Intron|ZNF493_ENST00000355504.4_Silent_p.S289S	NM_001076678.2	NP_001070146.1	Q6ZR52	ZN493_HUMAN	zinc finger protein 493	289					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						ATAAGGAGTCTTCACACCTTA	0.348000													3	77					0	0	0.009096	0	0
IGFN1	91156	broad.mit.edu	37	1	201184809	201184809	+	Silent	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr1:201184809G>A	ENST00000335211.4	+	15	9268	c.9138G>A	c.(9136-9138)gtG>gtA	p.V3046V	IGFN1_ENST00000295591.8_Silent_p.V206V|IGFN1_ENST00000451870.2_Intron	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						GGGCTGAGGTGGTGGGCAGCA	0.657000													25	46					0	0	0.003330	0	0
EVPL	2125	broad.mit.edu	37	17	74011093	74011093	+	Missense_Mutation	SNP	T	T	C			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr17:74011093T>C	ENST00000301607.3	-	17	2379	c.2126A>G	c.(2125-2127)aAc>aGc	p.N709S	EVPL_ENST00000586740.1_Missense_Mutation_p.N731S	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	709	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						CTCCTGGAAGTTGTTCTGCAG	0.682000													69	24					0	0	0.014410	0	0
NCOA6	23054	broad.mit.edu	37	20	33345550	33345550	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr20:33345550G>A	ENST00000374796.2	-	8	3571	c.1001C>T	c.(1000-1002)tCt>tTt	p.S334F	NCOA6_ENST00000359003.2_Missense_Mutation_p.S334F			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	334	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						TGTGCCCAGAGAACCCTGGGC	0.587000													56	62					0	0	0.014410	0	0
ZRSR1	7310	broad.mit.edu	37	5	112227939	112227939	+	Silent	SNP	T	T	C	rs712666	by1000genomes	TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr5:112227939T>C	ENST00000391338.1	+	1	627	c.603T>C	c.(601-603)tcT>tcC	p.S201S	REEP5_ENST00000379638.4_Intron|REEP5_ENST00000474542.2_Intron|REEP5_ENST00000513339.1_Intron|REEP5_ENST00000545426.1_Intron|REEP5_ENST00000504247.1_Intron|SRP19_ENST00000512790.1_3'UTR	NM_001204199.1	NP_001191128.1			zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1									p.S201S(1)		breast(1)|skin(1)|stomach(2)	4						TCCCAACATCTAGTCCTACCC	0.453000													3	97					0	0	0.000602	0	0
TRPM1	4308	broad.mit.edu	37	15	31341578	31341578	+	Splice_Site	SNP	T	T	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr15:31341578T>A	ENST00000542188.1	-	12	1936	c.1623_splice	c.e12+1	p.T541_splice	TRPM1_ENST00000397795.2_Splice_Site_p.T502_splice|TRPM1_ENST00000256552.6_Splice_Site_p.T524_splice	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	502			M -> K (in CSNB1C).		cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		GAGCACTCACTGTGTTATAAA	0.463000													52	115					0	0	0.014410	0	0
ARAP3	64411	broad.mit.edu	37	5	141051859	141051859	+	Silent	SNP	G	G	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr5:141051859G>T	ENST00000239440.4	-	10	1460	c.1395C>A	c.(1393-1395)gcC>gcA	p.A465A	ARAP3_ENST00000513878.1_Silent_p.A127A|ARAP3_ENST00000508305.1_Silent_p.A387A	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	465	PH 2.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						CCCCAGACTCGGCTGTGAAGC	0.627000													27	50					7.38237e-10	8.65671e-10	0.006320	1	0
MKI67	4288	broad.mit.edu	37	10	129911718	129911718	+	Silent	SNP	A	A	G			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr10:129911718A>G	ENST00000368654.3	-	8	2004	c.1629T>C	c.(1627-1629)acT>acC	p.T543T	MKI67_ENST00000368653.3_Silent_p.T183T	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	543					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				GGACAGGTGGAGTGTGCATTA	0.473000													50	135					0	0	0.014410	0	0
MRPS17P9	359760	broad.mit.edu	37	X	118513859	118513859	+	RNA	SNP	A	A	C			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chrX:118513859A>C	ENST00000413240.1	-	0	491																											ACAATTGGGGATATCGTGCTT	0.403000													30	120					0	0	0.013726	0	0
VWC2L	402117	broad.mit.edu	37	2	215279277	215279277	+	Silent	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr2:215279277G>A	ENST00000312504.5	+	2	1162	c.360G>A	c.(358-360)ggG>ggA	p.G120G	AC107218.3_ENST00000412896.1_RNA|VWC2L_ENST00000427124.1_Silent_p.G120G|AC107218.3_ENST00000437883.1_RNA	NM_001080500.2	NP_001073969.1	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain containing protein 2-like	120	VWFC 2.					extracellular region				breast(1)|endometrium(1)|large_intestine(3)|lung(10)|prostate(1)	16						AATATCACGGGAAAAATTACA	0.358000													16	4					0	0	0.006122	0	0
TTN	7273	broad.mit.edu	37	2	179464170	179464170	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr2:179464170G>A	ENST00000589042.1	-	290	56574	c.56350C>T	c.(56350-56352)Cgt>Tgt	p.R18784C	TTN-AS1_ENST00000589234.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R9844C|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R9911C|TTN_ENST00000342992.6_Missense_Mutation_p.R16216C|TTN_ENST00000460472.2_Missense_Mutation_p.R9719C|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R17143C|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000586452.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	17143	Fibronectin type-III 36.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGCCAGGACGACCTAAAATG	0.368000													55	20					0	0	0.014410	0	0
PDZD2	23037	broad.mit.edu	37	5	31799634	31799634	+	Silent	SNP	C	C	T	rs146790239		TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr5:31799634C>T	ENST00000438447.1	+	2	667	c.279C>T	c.(277-279)ttC>ttT	p.F93F	PDZD2_ENST00000282493.3_Silent_p.F93F			O15018	PDZD2_HUMAN	PDZ domain containing 2	93	PDZ 1.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						TCCCTGTTTTCGGGGACTATG	0.567000													78	29					0	0	0.014410	0	0
CCDC178	374864	broad.mit.edu	37	18	30847243	30847243	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr18:30847243C>T	ENST00000383096.3	-	13	1377	c.1195G>A	c.(1195-1197)Gtt>Att	p.V399I	CCDC178_ENST00000300227.8_Missense_Mutation_p.V399I|CCDC178_ENST00000579916.1_Intron|CCDC178_ENST00000583930.1_Missense_Mutation_p.V399I|CCDC178_ENST00000406524.2_Missense_Mutation_p.V399I|CCDC178_ENST00000402325.1_Missense_Mutation_p.V399I|CCDC178_ENST00000579947.1_Missense_Mutation_p.V399I|CCDC178_ENST00000403303.1_Missense_Mutation_p.V399I					coiled-coil domain containing 178																		TGGTCATAAACTCTTCTCAAA	0.308000													34	109					0	0	0.003271	0	0
SRPX	8406	broad.mit.edu	37	X	38079978	38079978	+	Missense_Mutation	SNP	A	A	G	rs72445954		TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chrX:38079978A>G	ENST00000378533.3	-	1	174	c.68T>C	c.(67-69)cTg>cCg	p.L23P	SRPX_ENST00000343800.6_Intron|TM4SF2_ENST00000465127.1_Intron|SRPX_ENST00000544439.1_Missense_Mutation_p.L23P|SRPX_ENST00000538295.1_Missense_Mutation_p.L23P|SRPX_ENST00000432886.2_Missense_Mutation_p.L23P	NM_006307.4	NP_006298.1	P78539	SRPX_HUMAN	sushi-repeat containing protein, X-linked	23			Missing.		cell adhesion	cell surface|membrane		p.L23delL(2)		autonomic_ganglia(1)|breast(2)|endometrium(5)|large_intestine(5)|lung(10)|prostate(2)	25						CGGGACGCgcagcagcagcag	0.726000											OREG0019726	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	10					0	0	0.000602	0	0
TMPRSS3	64699	broad.mit.edu	37	21	43808546	43808546	+	Missense_Mutation	SNP	C	C	T	rs140614903	byFrequency	TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr21:43808546C>T	ENST00000291532.3	-	5	1367	c.412G>A	c.(412-414)Gca>Aca	p.A138T	TMPRSS3_ENST00000398405.1_Missense_Mutation_p.A136T|TMPRSS3_ENST00000380399.1_Missense_Mutation_p.A222T|TMPRSS3_ENST00000474596.1_5'UTR|TMPRSS3_ENST00000433957.2_Missense_Mutation_p.A138T|TMPRSS3_ENST00000398397.3_Missense_Mutation_p.A138T	NM_032404.2	NP_115780.1	P57727	TMPS3_HUMAN	transmembrane protease, serine 3	138	SRCR.				cellular sodium ion homeostasis|proteolysis	endoplasmic reticulum membrane|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity|sodium channel regulator activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(4)|skin(1)	13						GCAACATTTGCGTAGTGACCC	0.512000													30	85					0	0	0.010818	0	0
BCL9L	283149	broad.mit.edu	37	11	118769345	118769345	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr11:118769345G>A	ENST00000334801.3	-	8	5243	c.4279C>T	c.(4279-4281)Ctc>Ttc	p.L1427F	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	1427					negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		TGGGTCATGAGGCCTTGTGGA	0.662000													26	12					0	0	0.003954	0	0
OR2AK2	391191	broad.mit.edu	37	1	248129469	248129469	+	Missense_Mutation	SNP	C	C	G			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr1:248129469C>G	ENST00000366480.3	+	1	935	c.836C>G	c.(835-837)tCc>tGc	p.S279C	OR2L13_ENST00000366478.2_Intron	NM_001004491.1	NP_001004491.1	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK, member 2	279					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	36	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			AGGCCACACTCCTTGCGTTCC	0.483000													18	59					0	0	0.004990	0	0
ALPPL2	251	broad.mit.edu	37	2	233272555	233272555	+	Splice_Site	SNP	G	G	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr2:233272555G>T	ENST00000295453.3	+	5	528	c.475_splice	c.e5-1	p.G159_splice		NM_031313.2	NP_112603.2	P10696	PPBN_HUMAN	alkaline phosphatase, placental-like 2	159					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			breast(2)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(1)	13		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	TCACCCTCAGGAAAGTCAGTG	0.617000													44	8					1.5731e-28	1.87819e-28	0.011902	1	0
SLC44A2	57153	broad.mit.edu	37	19	10747072	10747072	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr19:10747072C>T	ENST00000586078.1	+	15	1416	c.1307C>T	c.(1306-1308)tCg>tTg	p.S436L	SLC44A2_ENST00000407327.4_Missense_Mutation_p.S434L|SLC44A2_ENST00000335757.5_Missense_Mutation_p.S436L	NM_020428.3	NP_065161.3	Q8IWA5	CTL2_HUMAN	solute carrier family 44 (choline transporter), member 2	436					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			NS(1)|breast(3)|endometrium(5)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	GGTGGTGAGTCGGGCTACCAC	0.622000													37	121					0	0	0.003271	0	0
OTOF	9381	broad.mit.edu	37	2	26725240	26725240	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr2:26725240C>T	ENST00000272371.2	-	7	764	c.638G>A	c.(637-639)gGa>gAa	p.G213E	OTOF_ENST00000403946.3_Missense_Mutation_p.G213E	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	213					cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGTCCATCTCCTAGCCGAAT	0.567000													23	19					0	0	0.012319	0	0
ETV3L	440695	broad.mit.edu	37	1	157069119	157069119	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr1:157069119C>T	ENST00000454449.2	-	2	394	c.110G>A	c.(109-111)cGg>cAg	p.R37Q		NM_001004341.2	NP_001004341.1	Q6ZN32	ETV3L_HUMAN	ets variant 3-like	37						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Hepatocellular(266;0.158)	Prostate(1639;0.184)				CTGGATCTGCCGGGAGCCTGG	0.622000													26	44					0	0	0.006320	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52000671	52000671	+	Silent	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr19:52000671C>T	ENST00000291707.3	-	6	1489	c.1434G>A	c.(1432-1434)acG>acA	p.T478T	SIGLEC12_ENST00000598614.1_Silent_p.T360T	NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	478			T -> M (in dbSNP:rs3829658).		cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		ATGCCCCTAGCGTCACTCCTG	0.547000													56	90					0	0	0.014410	0	0
TUFM	7284	broad.mit.edu	37	16	28857367	28857367	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr16:28857367G>A	ENST00000313511.3	-	2	251	c.113C>T	c.(112-114)gCa>gTa	p.A38V		NM_003321.4	NP_003312.3	P49411	EFTU_HUMAN	Tu translation elongation factor, mitochondrial	35						mitochondrial nucleoid	GTP binding|GTPase activity|protein binding|translation elongation factor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	13						GAGAGGCAATGCCGGGGCTTT	0.652000													22	75					0	0	0.003330	0	0
MUC2	4583	broad.mit.edu	37	11	1080564	1080564	+	Silent	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr11:1080564C>T	ENST00000441003.2	+	9	1233	c.1206C>T	c.(1204-1206)ttC>ttT	p.F402F	MUC2_ENST00000359061.5_Silent_p.F402F	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	402	VWFD 2.					inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	TCACCACCTTCGATGGGAAGA	0.652000													17	5					0	0	0.006122	0	0
KLHL20	27252	broad.mit.edu	37	1	173702979	173702979	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr1:173702979C>T	ENST00000209884.4	+	3	287	c.151C>T	c.(151-153)Cct>Tct	p.P51S	KLHL20_ENST00000546011.1_Intron|KLHL20_ENST00000493170.1_3'UTR	NM_014458.3	NP_055273.2	Q9Y2M5	KLH20_HUMAN	kelch-like family member 20	51					cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			breast(3)|endometrium(6)|kidney(1)|large_intestine(8)|lung(14)|ovary(1)|upper_aerodigestive_tract(1)	34						AGACAAGCACCCTCGACAAAC	0.527000													18	116					0	0	0.008871	0	0
SULT1A1	6817	broad.mit.edu	37	16	28617511	28617511	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr16:28617511G>A	ENST00000395609.1	-	9	1399	c.641C>T	c.(640-642)tCc>tTc	p.S214F	SULT1A1_ENST00000350842.4_Missense_Mutation_p.S136F|SULT1A1_ENST00000314752.7_Missense_Mutation_p.S214F|SULT1A1_ENST00000569554.1_Missense_Mutation_p.S214F|SULT1A1_ENST00000395607.1_Missense_Mutation_p.S214F			P50225	ST1A1_HUMAN	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	214					3'-phosphoadenosine 5'-phosphosulfate metabolic process|catecholamine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity			endometrium(2)|kidney(7)|large_intestine(2)|lung(2)|ovary(1)|stomach(2)	16						CTCTGGCAGGGAGCGCCCCAC	0.547000													62	52					0	0	0.014410	0	0
KIAA1324	57535	broad.mit.edu	37	1	109745567	109745567	+	Splice_Site	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr1:109745567G>A	ENST00000369939.3	+	22	3158	c.2973_splice	c.e22-1	p.R992_splice	KIAA1324_ENST00000369938.1_3'UTR|KIAA1324_ENST00000529753.1_Splice_Site_p.R905_splice	NM_020775.4	NP_065826.2	Q6UXG2	K1324_HUMAN	KIAA1324	992					macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		CTCTTTCAGAGGACTCCTGAT	0.537000													64	91					0	0	0.014410	0	0
PABPC3	5042	broad.mit.edu	37	13	25670378	25670378	+	Silent	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr13:25670378C>T	ENST00000281589.3	+	1	79	c.42C>T	c.(40-42)taC>taT	p.Y14Y		NM_030979.2	NP_112241.2	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	14	RRM 1.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding	p.Y14*(1)		breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|pancreas(1)|skin(3)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		CCTCGCTCTACGTGGGGGACC	0.637000													23	65					0	0	0.003954	0	0
RERE	473	broad.mit.edu	37	1	8420555	8420555	+	Silent	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr1:8420555G>A	ENST00000337907.3	-	19	3646	c.3012C>T	c.(3010-3012)ccC>ccT	p.P1004P	RERE_ENST00000476556.1_Silent_p.P450P|RERE_ENST00000400907.2_Intron|RERE_ENST00000400908.2_Silent_p.P1004P|RERE_ENST00000377464.1_Silent_p.P736P	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	1004	Pro-rich.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		TCAGCCCGGGGGGCTGGGCGG	0.721000													9	3					0	0	0.004482	0	0
TEKT1	83659	broad.mit.edu	37	17	6722611	6722611	+	Missense_Mutation	SNP	T	T	A	rs143710127		TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr17:6722611T>A	ENST00000338694.2	-	3	386	c.257A>T	c.(256-258)aAt>aTt	p.N86I	TEKT1_ENST00000535086.1_Intron	NM_053285.1	NP_444515.1	Q969V4	TEKT1_HUMAN	tektin 1	86					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)	20		Myeloproliferative disorder(207;0.0255)				ATCAGTTACATTCACAAGCTG	0.458000													15	98					0	0	0.004990	0	0
NLGN1	22871	broad.mit.edu	37	3	173998380	173998380	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr3:173998380C>T	ENST00000457714.1	+	7	2188	c.1759C>T	c.(1759-1761)Cat>Tat	p.H587Y	NLGN1_ENST00000401917.3_Missense_Mutation_p.H627Y|NLGN1_ENST00000545397.1_Missense_Mutation_p.H587Y|NLGN1_ENST00000361589.4_Missense_Mutation_p.H587Y	NM_014932.2	NP_055747.1	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	604					calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(2)|lung(54)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	83	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			ACTTTATCTCCATATTGGATT	0.398000													64	88					0	0	0.014410	0	0
SLC6A9	6536	broad.mit.edu	37	1	44466702	44466702	+	Missense_Mutation	SNP	A	A	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr1:44466702A>T	ENST00000372310.3	-	11	1526	c.1361T>A	c.(1360-1362)aTg>aAg	p.M454K	SLC6A9_ENST00000372307.3_Missense_Mutation_p.M389K|SLC6A9_ENST00000537678.1_3'UTR|SLC6A9_ENST00000475075.2_Missense_Mutation_p.M343K|SLC6A9_ENST00000372306.3_Missense_Mutation_p.M454K|SLC6A9_ENST00000360584.2_Missense_Mutation_p.M527K|SLC6A9_ENST00000357730.2_Missense_Mutation_p.M473K	NM_001024845.2	NP_001020016.1	P48067	SC6A9_HUMAN	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	527						integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			endometrium(3)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(2)	22	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	ATAGTTGTCCATCAGCAGCAG	0.627000													24	47					0	0	0.002780	0	0
ITGB8	3696	broad.mit.edu	37	7	20449354	20449354	+	Missense_Mutation	SNP	A	A	G			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr7:20449354A>G	ENST00000222573.3	+	13	2824	c.2140A>G	c.(2140-2142)Aat>Gat	p.N714D	ITGB8_ENST00000537992.1_Missense_Mutation_p.N579D	NM_002214.2	NP_002205.1	P26012	ITB8_HUMAN	integrin, beta 8	714					cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(4)|stomach(2)|urinary_tract(1)	37						ATGGAATAGTAATAAAATTAA	0.323000													59	92					0	0	0.014410	0	0
PVRL4	81607	broad.mit.edu	37	1	161044509	161044509	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr1:161044509C>T	ENST00000368012.3	-	5	1194	c.892G>A	c.(892-894)Gac>Aac	p.D298N	PVRL4_ENST00000453926.2_Missense_Mutation_p.D32N	NM_030916.2	NP_112178.2	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4	298	Ig-like C2-type 2.				adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|urinary_tract(1)	20	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			CCCAAAGTGTCCCCATCCACT	0.597000													26	33					0	0	0.003954	0	0
TAS2R39	259285	broad.mit.edu	37	7	142880577	142880577	+	Silent	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr7:142880577C>T	ENST00000446620.1	+	1	66	c.66C>T	c.(64-66)tgC>tgT	p.C22C		NM_176881.2	NP_795362.2	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	22					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	Melanoma(164;0.059)					CTAAACTCTGCGATCCTGCAG	0.408000													14	49					0	0	0.002450	0	0
GLT8D2	83468	broad.mit.edu	37	12	104390557	104390557	+	Missense_Mutation	SNP	C	C	T	rs7133444		TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr12:104390557C>T	ENST00000360814.4	-	8	961	c.556G>A	c.(556-558)Gat>Aat	p.D186N	GLT8D2_ENST00000546436.1_Missense_Mutation_p.D186N|GLT8D2_ENST00000548660.1_Missense_Mutation_p.D186N	NM_031302.3	NP_112592.1	Q9H1C3	GL8D2_HUMAN	glycosyltransferase 8 domain containing 2	186						integral to membrane	transferase activity, transferring glycosyl groups	p.D186N(1)		kidney(3)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)	16						GAGGGCAAATCGCAGTCATCT	0.502000													60	30					0	0	0.014410	0	0
ZCCHC7	84186	broad.mit.edu	37	9	37357180	37357180	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr9:37357180G>A	ENST00000336755.5	+	9	1653	c.1547G>A	c.(1546-1548)gGc>gAc	p.G516D	ZCCHC7_ENST00000461038.1_3'UTR|ZCCHC7_ENST00000534928.1_Missense_Mutation_p.G226D	NM_032226.2	NP_115602.2	Q8N3Z6	ZCHC7_HUMAN	zinc finger, CCHC domain containing 7	516							nucleic acid binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	30				GBM - Glioblastoma multiforme(29;0.0137)		GGCAAGAGGGGCAAGCAGAAG	0.443000													4	84					0	0	0.009096	0	0
TNFAIP8L3	388121	broad.mit.edu	37	15	51350174	51350174	+	Silent	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr15:51350174G>A	ENST00000327536.5	-	3	882	c.783C>T	c.(781-783)ttC>ttT	p.F261F	RP11-108K3.1_ENST00000559909.1_lincRNA	NM_207381.2	NP_997264.2	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 3	261										endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	11				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		GGGTGGAGAGGAACTCCACAT	0.517000													43	43					0	0	0.010771	0	0
MYOF	26509	broad.mit.edu	37	10	95095700	95095700	+	Missense_Mutation	SNP	G	G	C			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr10:95095700G>C	ENST00000371501.4	-	41	4663	c.4541C>G	c.(4540-4542)cCt>cGt	p.P1514R	MYOF_ENST00000358334.5_Missense_Mutation_p.P1501R|MYOF_ENST00000359263.4_Missense_Mutation_p.P1514R|MYOF_ENST00000371502.4_Missense_Mutation_p.P1533R			Q9NZM1	MYOF_HUMAN	myoferlin	1514					blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						AACCACAGAAGGATCTTCATT	0.408000													11	199					0	0	0.010729	0	0
MGAT3	4248	broad.mit.edu	37	22	39884939	39884939	+	Silent	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr22:39884939C>T	ENST00000341184.6	+	2	1802	c.1587C>T	c.(1585-1587)gaC>gaT	p.D529D		NM_001098270.1|NM_002409.4	NP_001091740.1|NP_002400.3	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	529					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity			endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|prostate(1)|skin(1)	24	Melanoma(58;0.04)					GCAAACTGGACGAGGCGGAAG	0.701000													8	17					0	0	0.008291	0	0
NT5C1A	84618	broad.mit.edu	37	1	40126862	40126862	+	Silent	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr1:40126862G>A	ENST00000235628.1	-	5	629	c.630C>T	c.(628-630)ttC>ttT	p.F210F		NM_032526.1	NP_115915.1	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	210					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			breast(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(2)	15	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CGTCCCCATCGAAGGCCACGC	0.612000													43	11					0	0	0.006999	0	0
JUP	3728	broad.mit.edu	37	17	39925418	39925418	+	Silent	SNP	C	C	T	rs140539043	byFrequency	TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr17:39925418C>T	ENST00000393931.3	-	4	628	c.510G>A	c.(508-510)tcG>tcA	p.S170S	JUP_ENST00000393930.1_Silent_p.S170S|JUP_ENST00000540235.1_Silent_p.S170S|JUP_ENST00000310706.5_Silent_p.S170S	NM_002230.2	NP_002221.1	P14923	PLAK_HUMAN	junction plakoglobin	170					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	23		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		CCTCCTTCTTCGACAGCTGGT	0.657000													59	6					0	0	0.014410	0	0
GGT7	2686	broad.mit.edu	37	20	33449261	33449261	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr20:33449261G>A	ENST00000336431.5	-	4	706	c.662C>T	c.(661-663)tCc>tTc	p.S221F		NM_178026.2	NP_821158.2	Q9UJ14	GGT7_HUMAN	gamma-glutamyltransferase 7	221					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity	p.S221F(1)		NS(2)|breast(1)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|skin(2)	20						GGTCTCCCAGGATCTTTGCAG	0.527000													32	58					0	0	0.008361	0	0
LRP1B	53353	broad.mit.edu	37	2	141243054	141243054	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr2:141243054C>T	ENST00000389484.3	-	59	10254	c.9283G>A	c.(9283-9285)Gat>Aat	p.D3095N		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3095					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCAATCCAATCGACAGCAAGT	0.373000										TSP Lung(27;0.18)			44	13					0	0	0.013114	0	0
MGP	4256	broad.mit.edu	37	12	15035126	15035126	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr12:15035126C>T	ENST00000539261.1	-	4	393	c.259G>A	c.(259-261)Gga>Aga	p.G87R	C12orf60_ENST00000527783.1_Intron|MGP_ENST00000228938.5_Missense_Mutation_p.G112R	NM_000900.3	NP_000891.2	P08493	MGP_HUMAN	matrix Gla protein	87	Gla.				cartilage condensation|cell differentiation|ossification|regulation of bone mineralization	proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent|structural constituent of bone			large_intestine(1)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	7						GCATTGTATCCATAAACCATG	0.483000													60	170					0	0	0.014410	0	0
ZNF845	91664	broad.mit.edu	37	19	53856730	53856730	+	Silent	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr19:53856730G>A	ENST00000458035.1	+	4	2919	c.2802G>A	c.(2800-2802)aaG>aaA	p.K934K	ZNF845_ENST00000595091.1_Silent_p.K934K	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	934					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.K934K(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						TAATTCATAAGACAATTCATA	0.368000													3	33					0	0	0.009096	0	0
DPYD	1806	broad.mit.edu	37	1	97981340	97981340	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr1:97981340C>T	ENST00000370192.3	-	13	1782	c.1682G>A	c.(1681-1683)cGa>cAa	p.R561Q		NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	561					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	AAAAGCTCTTCGAATCATTGA	0.388000													37	17					0	0	0.011902	0	0
FAM216B	144809	broad.mit.edu	37	13	43360951	43360951	+	Missense_Mutation	SNP	A	A	G			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr13:43360951A>G	ENST00000537894.1	+	3	275	c.152A>G	c.(151-153)aAc>aGc	p.N51S	FAM216B_ENST00000313851.1_Missense_Mutation_p.N51S	NM_182508.2	NP_872314.1	Q8N7L0	CM030_HUMAN	family with sequence similarity 216, member B	51																	AGGATTTACAACTCCAGGCCC	0.502000													51	159					0	0	0.014410	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													5	75					0	0	0.000602	0	0
SLC7A8	23428	broad.mit.edu	37	14	23609687	23609687	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr14:23609687G>A	ENST00000316902.7	-	5	1506	c.781C>T	c.(781-783)Ccc>Tcc	p.P261S	SLC7A8_ENST00000469263.1_Missense_Mutation_p.P261S|SLC7A8_ENST00000529705.2_Missense_Mutation_p.P156S|SLC7A8_ENST00000532568.1_5'UTR|SLC7A8_ENST00000453702.1_Missense_Mutation_p.P58S|SLC7A8_ENST00000422941.2_Intron	NM_012244.3	NP_036376.2	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (amino acid transporter light chain, L system), member 8	261					blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			autonomic_ganglia(1)|endometrium(6)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|skin(1)	24	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	CACTTGTAGGGATCAACAAGC	0.557000													61	118					0	0	0.014410	0	0
STAG3L2	442582	broad.mit.edu	37	7	74306378	74306378	+	RNA	DEL	C	C	-			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr7:74306378delC	ENST00000423186.1	-	0	296							P0CL84	ST3L2_HUMAN								nucleus	binding			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(1)|pancreas(1)	5						GGGCGGGGGGCCCCGCGCTCC	0.731													2	4	---	---	---	---					
PRSS3P2	154754	broad.mit.edu	37	7	142481996	142481997	+	RNA	INS	-	-	C			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr7:142481996_142481997insC	ENST00000603901.1	+	0	591					NR_001296.3																						TCCCAAGGTGGGGGGCTGAGGA	0.564													8	18	---	---	---	---					
KMT2C	58508	broad.mit.edu	37	7	151874148	151874148	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr7:151874148delT	ENST00000355193.2	-	38	8608	c.8390delA	c.(8389-8391)agfs	p.K2797fs	KMT2C_ENST00000262189.6_Frame_Shift_Del_p.K2797fs					lysine (K)-specific methyltransferase 2C									p.K2797fs*26(20)									TTCTTGTTCCTTTTTTTTTGG	0.348													8	172	---	---	---	---					
ALPK3	57538	broad.mit.edu	37	15	85382960	85382971	+	In_Frame_Del	DEL	CCAGGCCTCTGC	CCAGGCCTCTGC	-			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr15:85382960_85382971delCCAGGCCTCTGC	ENST00000258888.5	+	5	1223_1234	c.1056_1067delCCAGGCCTCTGC	c.(1054-1068)tac>ta	p.YQASA352del		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	352	Ig-like 1.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CCGCCATCTACCAGGCCTCTGCCCAGAACAGC	0.627													11	92	---	---	---	---					
KRT16P6	353194	broad.mit.edu	37	17	16725606	16725607	+	RNA	INS	-	-	C			TCGA-ER-A2ND-06A-11D-A196-08	TCGA-ER-A2ND-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	844cd78e-19d6-45e2-9dba-8cd6cdb71a5d	d5708200-6909-4714-8798-66f9caa736ca	g.chr17:16725606_16725607insC	ENST00000417510.1	-	0	286_287																											CGCCATAGCCGCCCCCCAGCCT	0.668													10	21	---	---	---	---