Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF473	25888	broad.mit.edu	37	19	50548418	50548418	+	Missense_Mutation	SNP	C	C	G			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr19:50548418C>G	ENST00000595661.1	+	6	1213	c.718C>G	c.(718-720)Caa>Gaa	p.Q240E	ZNF473_ENST00000601364.1_Intron|ZNF473_ENST00000270617.3_Missense_Mutation_p.Q240E|CTD-2126E3.3_ENST00000599410.1_RNA|CTD-2126E3.3_ENST00000599914.1_RNA|ZNF473_ENST00000391821.2_Missense_Mutation_p.Q240E|ZNF473_ENST00000445728.3_Missense_Mutation_p.Q228E			Q8WTR7	ZN473_HUMAN	zinc finger protein 473	240					histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(9)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	37		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		CACTGTCCATCAAGAGTGTGA	0.448000													20	76					0	0	9.7654e-05	0	0
PGK2	5232	broad.mit.edu	37	6	49754466	49754466	+	Missense_Mutation	SNP	A	A	T			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr6:49754466A>T	ENST00000304801.3	-	1	587	c.435T>A	c.(433-435)gaT>gaA	p.D145E		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	145					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					CTTCTATTTTATCTGGCTCAG	0.507000													33	35					0	0	7.24521e-05	0	0
PCDHGA7	56108	broad.mit.edu	37	5	140764356	140764356	+	Silent	SNP	G	G	A			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr5:140764356G>A	ENST00000518325.1	+	1	1890	c.1890G>A	c.(1888-1890)cgG>cgA	p.R630R	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_018920.2	NP_061743.1														NS(1)|biliary_tract(1)|endometrium(8)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|skin(1)|stomach(3)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCACGGCTCGGGCCCTGCTGG	0.647000													26	49					0	0	0.000184323	0	0
KDM8	79831	broad.mit.edu	37	16	27231718	27231718	+	Missense_Mutation	SNP	T	T	C			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr16:27231718T>C	ENST00000286096.4	+	7	1171	c.998T>C	c.(997-999)aTg>aCg	p.M333T	KDM8_ENST00000380948.2_Intron|KDM8_ENST00000441782.2_Missense_Mutation_p.M371T|KDM8_ENST00000568965.1_Intron|KDM8_ENST00000567785.1_3'UTR	NM_024773.2	NP_079049.2	Q8N371	KDM8_HUMAN	lysine (K)-specific demethylase 8	333	JmjC.				G2/M transition of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|histone demethylase activity (H3-K36 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen										CCCCAGGTGATGGGGAGGAAG	0.622000													5	212					0	0	3.59834e-05	0	0
CREB3L2	64764	broad.mit.edu	37	7	137612996	137612996	+	Silent	SNP	C	C	T	rs146953741	byFrequency	TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr7:137612996C>T	ENST00000330387.6	-	2	570	c.219G>A	c.(217-219)ccG>ccA	p.P73P	CREB3L2_ENST00000456390.1_Silent_p.P73P|CREB3L2_ENST00000458726.1_Silent_p.P10P|CREB3L2_ENST00000452463.1_Silent_p.P73P	NM_194071.3	NP_919047.2	Q70SY1	CR3L2_HUMAN	cAMP responsive element binding protein 3-like 2	73					chondrocyte differentiation|positive regulation of transcription, DNA-dependent|response to endoplasmic reticulum stress|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	cAMP response element binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L2(158)	breast(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19						TGAGAGGCGCCGGGGACGTCG	0.577000			T	FUS	fibromyxoid sarcoma								20	13					0	0	0.000132079	0	0
MUC4	4585	broad.mit.edu	37	3	195515876	195515876	+	Missense_Mutation	SNP	C	C	G			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr3:195515876C>G	ENST00000463781.3	-	2	3034	c.2575G>C	c.(2575-2577)Gta>Cta	p.V859L	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.V859L|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	864	Ser-rich.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CCTGTGCTTACTGGGATGGCA	0.572000													11	27					0	0	6.40141e-05	0	0
DMXL1	1657	broad.mit.edu	37	5	118464914	118464914	+	Missense_Mutation	SNP	C	C	G			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr5:118464914C>G	ENST00000311085.8	+	10	1191	c.1111C>G	c.(1111-1113)Ctt>Gtt	p.L371V	DMXL1_ENST00000539542.1_Missense_Mutation_p.L371V	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	371										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		AGACATTCCACTTCTTCCATC	0.274000													8	27					0	0	2.17888e-05	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					4	33					0	0	2.17888e-05	0	0
SPEG	10290	broad.mit.edu	37	2	220354563	220354563	+	Silent	SNP	C	C	T			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr2:220354563C>T	ENST00000312358.7	+	36	8955	c.8823C>T	c.(8821-8823)tcC>tcT	p.S2941S	AC053503.11_ENST00000429882.1_RNA|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	2941	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		TGGTCAGCTCCCCTGGGAGCA	0.662000													18	34					0	0	0.000229342	0	0
NDUFAF2	91942	broad.mit.edu	37	5	60369037	60369037	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr5:60369037G>A	ENST00000296597.5	+	2	340	c.213G>A	c.(211-213)tgG>tgA	p.W71*	NDUFAF2_ENST00000511107.1_Intron|NDUFAF2_ENST00000512623.1_3'UTR	NM_174889.4	NP_777549.1	Q8N183	MIMIT_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 2	71						membrane|mitochondrion	electron carrier activity|NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|ovary(1)	6		Lung NSC(810;3.36e-05)|Prostate(74;0.0225)|Ovarian(174;0.17)|Breast(144;0.237)				CAACAGAATGGGAAGGTAAGT	0.318000													92	96					0	0	0.000147903	0	0
PHC3	80012	broad.mit.edu	37	3	169831280	169831280	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr3:169831280G>A	ENST00000494943.1	-	11	2253	c.2185C>T	c.(2185-2187)Cag>Tag	p.Q729*	PHC3_ENST00000495893.1_Nonsense_Mutation_p.Q741*|PHC3_ENST00000467570.1_Nonsense_Mutation_p.Q688*			Q8NDX5	PHC3_HUMAN	polyhomeotic homolog 3 (Drosophila)	729					multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|upper_aerodigestive_tract(2)	26	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			TTCACAGGCTGTTCTATTAGC	0.338000													10	38					0	0	3.86212e-05	0	0
DIS3	22894	broad.mit.edu	37	13	73350130	73350130	+	Missense_Mutation	SNP	C	C	G			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr13:73350130C>G	ENST00000377767.4	-	5	855	c.755G>C	c.(754-756)aGa>aCa	p.R252T	DIS3_ENST00000545453.1_Missense_Mutation_p.R90T|DIS3_ENST00000377780.4_Missense_Mutation_p.R222T	NM_014953.3	NP_055768.3	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)	252					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(7)|kidney(5)|large_intestine(10)|lung(6)|prostate(2)|skin(1)	35		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		CCTGCTAGCTCTAAATGTTCC	0.328000										Multiple Myeloma(4;0.011)			19	1					0	0	0.000295444	0	0
GRIA1	2890	broad.mit.edu	37	5	153085596	153085596	+	Missense_Mutation	SNP	T	T	G			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr5:153085596T>G	ENST00000285900.5	+	11	2135	c.1792T>G	c.(1792-1794)Ttc>Gtc	p.F598V	GRIA1_ENST00000518142.1_Missense_Mutation_p.F518V|GRIA1_ENST00000521843.2_Missense_Mutation_p.F529V|GRIA1_ENST00000518783.1_Missense_Mutation_p.F608V|GRIA1_ENST00000448073.4_Missense_Mutation_p.F608V|GRIA1_ENST00000340592.5_Missense_Mutation_p.F598V	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	598					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CCTGGGAGCCTTCATGCAGCA	0.453000													11	48					0	0	3.86212e-05	0	0
SLC8A1	6546	broad.mit.edu	37	2	40342620	40342620	+	Missense_Mutation	SNP	G	G	C			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr2:40342620G>C	ENST00000406785.1	-	8	2776	c.2587C>G	c.(2587-2589)Cag>Gag	p.Q863E	SLC8A1_ENST00000406391.2_Missense_Mutation_p.Q863E|SLC8A1_ENST00000405269.1_Missense_Mutation_p.Q863E|SLC8A1_ENST00000403092.1_Missense_Mutation_p.Q899E|SLC8A1_ENST00000402441.1_Missense_Mutation_p.Q863E|SLC8A1_ENST00000332839.4_Missense_Mutation_p.Q899E|SLC8A1_ENST00000408028.2_Missense_Mutation_p.Q891E|SLC8A1-AS1_ENST00000601679.1_RNA|SLC8A1-AS1_ENST00000599956.1_RNA|SLC8A1-AS1_ENST00000599740.1_RNA|SLC8A1-AS1_ENST00000599268.1_RNA|SLC8A1-AS1_ENST00000598247.1_RNA|SLC8A1-AS1_ENST00000597385.1_RNA|SLC8A1-AS1_ENST00000597170.1_RNA|SLC8A1_ENST00000405901.3_Missense_Mutation_p.Q894E|SLC8A1-AS1_ENST00000596532.1_RNA|SLC8A1-AS1_ENST00000593848.1_RNA|SLC8A1-AS1_ENST00000593878.1_RNA|SLC8A1_ENST00000542756.1_Missense_Mutation_p.Q894E|SLC8A1_ENST00000542024.1_Missense_Mutation_p.Q863E|SLC8A1-AS1_ENST00000444629.1_RNA|SLC8A1-AS1_ENST00000435515.1_RNA			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	899					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	ACTTTGAACTGTTCCCCATTG	0.552000													12	37					0	0	6.40141e-05	0	0
GAB2	9846	broad.mit.edu	37	11	77930378	77930378	+	Silent	SNP	G	G	T	rs115982223	byFrequency	TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr11:77930378G>T	ENST00000361507.4	-	10	2056	c.1971C>A	c.(1969-1971)acC>acA	p.T657T	GAB2_ENST00000340149.2_Silent_p.T619T	NM_080491.2	NP_536739.1	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2	657					osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity		INTS4/GAB2(2)	NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(8)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	24	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			ACTCCTGCATGGTGTTCTGCA	0.597000													22	2293					0.000219431	0.00807418	0.000219431	1	0
SSH2	85464	broad.mit.edu	37	17	27975227	27975227	+	Silent	SNP	C	C	A			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr17:27975227C>A	ENST00000269033.3	-	13	1432	c.1281G>T	c.(1279-1281)acG>acT	p.T427T	RP11-68I3.2_ENST00000581474.1_RNA|SSH2_ENST00000540801.1_Silent_p.T454T	NM_033389.2	NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	427	Tyrosine-protein phosphatase.				actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GCTTGGTTACCGTTCGTCTTT	0.502000													7	246					0.000157383	0.00585076	0.000157383	1	0
C12orf5	57103	broad.mit.edu	37	12	4460443	4460443	+	Missense_Mutation	SNP	T	T	C			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr12:4460443T>C	ENST00000179259.4	+	5	348	c.281T>C	c.(280-282)gTt>gCt	p.V94A	C12orf5_ENST00000537251.1_3'UTR	NM_020375.2	NP_065108.1	Q9NQ88	TIGAR_HUMAN	chromosome 12 open reading frame 5	94						intracellular	fructose-2,6-bisphosphate 2-phosphatase activity			endometrium(1)|large_intestine(1)|lung(5)|skin(3)	10			all cancers(3;1.15e-07)|Colorectal(7;0.00165)|OV - Ovarian serous cystadenocarcinoma(31;0.00596)|COAD - Colon adenocarcinoma(12;0.0229)|GBM - Glioblastoma multiforme(3;0.0266)|STAD - Stomach adenocarcinoma(119;0.206)			AAATACGGGGTTGTAGAAGGC	0.448000													25	53					0	0	0.000147802	0	0
OR1M1	125963	broad.mit.edu	37	19	9204595	9204595	+	Silent	SNP	C	C	T			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr19:9204595C>T	ENST00000429566.3	+	1	741	c.675C>T	c.(673-675)atC>atT	p.I225I		NM_001004456.1	NP_001004456.1	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M, member 1	225					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(17)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						TTGTGGCCATCATGAAGGTCC	0.562000													25	133					0	0	0.000184323	0	0
TMEM131	23505	broad.mit.edu	37	2	98421906	98421906	+	Silent	SNP	G	G	A			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr2:98421906G>A	ENST00000186436.5	-	21	2445	c.2217C>T	c.(2215-2217)aaC>aaT	p.N739N		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	739						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						CAAAATAAATGTTTGCAATCT	0.383000													19	44					0	0	7.07596e-05	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102304772	102304772	+	RNA	SNP	T	T	C			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr15:102304772T>C	ENST00000561463.1	+	0	12818																											CACAGCGGCGTGACGAGACTC	0.587000													3	29					0	0	0.00024832	0	0
TUBA1B	10376	broad.mit.edu	37	12	49522718	49522718	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr12:49522718C>T	ENST00000336023.5	-	4	473	c.379G>A	c.(379-381)Gac>Aac	p.D127N	RP11-386G11.10_ENST00000547387.1_RNA	NM_006082.2	NP_006073.2	P68363	TBA1B_HUMAN	tubulin, alpha 1b	127					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(2)|lung(4)	12						GTGCACTGGTCAGCCTGTAGG	0.428000													12	124					0	0	0.000219431	0	0
AGMO	392636	broad.mit.edu	37	7	15430341	15430341	+	Nonsense_Mutation	SNP	A	A	T			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr7:15430341A>T	ENST00000342526.3	-	8	946	c.777T>A	c.(775-777)taT>taA	p.Y259*		NM_001004320.1	NP_001004320.1	Q6ZNB7	ALKMO_HUMAN	alkylglycerol monooxygenase	259					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding			breast(1)|kidney(1)|large_intestine(6)|liver(1)|lung(30)|prostate(1)|skin(2)	42						GTGTTAAGCCATATACAACTT	0.279000													17	151					0	0	0.000375601	0	0
OR1M1	125963	broad.mit.edu	37	19	9204673	9204673	+	Silent	SNP	C	C	T			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr19:9204673C>T	ENST00000429566.3	+	1	819	c.753C>T	c.(751-753)ttC>ttT	p.F251F		NM_001004456.1	NP_001004456.1	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M, member 1	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(17)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						TTGCTCTCTTCTATGGGACCA	0.572000													30	174					0	0	0.000227799	0	0
ODF3	113746	broad.mit.edu	37	11	197726	197726	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr11:197726G>A	ENST00000325113.4	+	3	592	c.275G>A	c.(274-276)cGc>cAc	p.R92H	ODF3_ENST00000342593.5_Missense_Mutation_p.R92H|ODF3_ENST00000525282.1_Missense_Mutation_p.R92H|BET1L_ENST00000410108.1_Intron	NM_053280.3	NP_444510.2	Q96PU9	ODF3A_HUMAN	outer dense fiber of sperm tails 3	92					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm				biliary_tract(1)|breast(1)|kidney(1)|large_intestine(2)|ovary(1)|prostate(2)|skin(1)	9		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;3.95e-27)|Epithelial(43;2.66e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.55e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		ATCCTGGGGCGCTACCAAACC	0.622000													31	36					0	0	0.000191422	0	0
RLIM	51132	broad.mit.edu	37	X	73811938	73811938	+	Silent	SNP	G	G	C	rs61754468	by1000genomes	TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chrX:73811938G>C	ENST00000332687.6	-	4	1430	c.1212C>G	c.(1210-1212)acC>acG	p.T404T	RLIM_ENST00000349225.2_Silent_p.T404T	NM_016120.3	NP_057204.2	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	404					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding	p.T404T(6)		breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GCCTTAACATGGTCTGAATTG	0.413000													4	41					0	0	0.00024832	0	0
QARS	5859	broad.mit.edu	37	3	49137495	49137495	+	Silent	SNP	G	G	A			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr3:49137495G>A	ENST00000306125.6	-	14	1531	c.1194C>T	c.(1192-1194)ggC>ggT	p.G398G	QARS_ENST00000414533.1_Silent_p.G387G			P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	398					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			breast(1)|endometrium(1)|large_intestine(9)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	GTGTGGCCTCGCCCTCTGAAA	0.552000													36	84					0	0	0.000191422	0	0
CCNB3	85417	broad.mit.edu	37	X	50053973	50053973	+	Missense_Mutation	SNP	A	A	G			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chrX:50053973A>G	ENST00000376042.1	+	6	3102	c.2804A>G	c.(2803-2805)gAg>gGg	p.E935G	CCNB3_ENST00000376038.1_Intron|CCNB3_ENST00000348603.2_Intron|CCNB3_ENST00000276014.7_Missense_Mutation_p.E935G			Q8WWL7	CCNB3_HUMAN	cyclin B3	935					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					GCTCTGAATGAGAAACCCACC	0.458000													18	23					0	0	0.000229342	0	0
FAM86C1	55199	broad.mit.edu	37	11	71507263	71507263	+	Silent	SNP	A	A	G			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr11:71507263A>G	ENST00000528685.1	+	3	360	c.360A>G	c.(358-360)acA>acG	p.T120T	FAM86C1_ENST00000346333.6_Intron|FAM86C1_ENST00000359244.4_Intron|FAM86C1_ENST00000426628.2_Intron			Q9NVL1	FA86C_HUMAN	family with sequence similarity 86, member C1	0										lung(1)	1						CTGTCCCTACAGGACTCCAGT	0.627000													7	950					0	0	0.000295444	0	0
POP1	10940	broad.mit.edu	37	8	99170218	99170218	+	Missense_Mutation	SNP	G	G	T			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr8:99170218G>T	ENST00000401707.2	+	16	2875	c.2794G>T	c.(2794-2796)Gcg>Tcg	p.A932S	POP1_ENST00000349693.3_Missense_Mutation_p.A932S	NM_001145860.1|NM_001145861.1	NP_001139332.1|NP_001139333.1	Q99575	POP1_HUMAN	processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)	932					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			autonomic_ganglia(1)|breast(3)|endometrium(4)|large_intestine(9)|lung(15)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			TGATGGCCCGGCGGGGGAAGA	0.582000													48	90					4.18559e-23	1.67703e-21	0.000147903	1	0
PRSS23	11098	broad.mit.edu	37	11	86519475	86519475	+	Missense_Mutation	SNP	G	G	T			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr11:86519475G>T	ENST00000280258.5	+	2	1215	c.790G>T	c.(790-792)Ggg>Tgg	p.G264W	PRSS23_ENST00000533902.2_Intron|PRSS23_ENST00000441050.1_Missense_Mutation_p.G232W	NM_007173.4	NP_009104.1	O95084	PRS23_HUMAN	protease, serine, 23	264					proteolysis	extracellular region|nucleus	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(9)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	18		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TATGAAGATTGGGGTGAGCCC	0.488000													15	1373					0.000274275	0.00999026	0.000274275	1	0
TMEM63A	9725	broad.mit.edu	37	1	226055681	226055681	+	Missense_Mutation	SNP	A	A	T			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr1:226055681A>T	ENST00000366835.3	-	7	691	c.421T>A	c.(421-423)Tcc>Acc	p.S141T		NM_014698.2	NP_055513.2	O94886	TM63A_HUMAN	transmembrane protein 63A	141						integral to membrane|lysosomal membrane	nucleotide binding			breast(2)|endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24	Breast(184;0.197)					CTCTGGAAGGACAGGTAGTGG	0.547000													18	68					0	0	9.7654e-05	0	0
FGD3	89846	broad.mit.edu	37	9	95772662	95772662	+	Silent	SNP	G	G	A			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr9:95772662G>A	ENST00000375482.3	+	7	1468	c.972G>A	c.(970-972)gcG>gcA	p.A324A	FGD3_ENST00000337352.6_Silent_p.A324A|FGD3_ENST00000416701.2_Silent_p.A324A	NM_001083536.1	NP_001077005.1	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	324	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|urinary_tract(1)	17						GGAAGGATGCGGAGAGTGAGC	0.657000													7	24					0	0	0.000157383	0	0
OR1M1	125963	broad.mit.edu	37	19	9204670	9204670	+	Silent	SNP	C	C	A			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr19:9204670C>A	ENST00000429566.3	+	1	816	c.750C>A	c.(748-750)ctC>ctA	p.L250L		NM_001004456.1	NP_001004456.1	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M, member 1	250					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(17)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						TGGTTGCTCTCTTCTATGGGA	0.572000													31	172					3.80469e-20	1.50766e-18	0.000279167	1	0
HIVEP1	3096	broad.mit.edu	37	6	12162032	12162032	+	Missense_Mutation	SNP	G	G	T			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr6:12162032G>T	ENST00000379388.2	+	8	7180	c.6848G>T	c.(6847-6849)aGa>aTa	p.R2283I	HIVEP1_ENST00000541134.1_Missense_Mutation_p.R148I	NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	2283					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CGTGCTGCGAGAGATGAAAAC	0.532000													17	85					2.23348e-06	8.66015e-05	0.000422831	1	0
MBD5	55777	broad.mit.edu	37	2	149247723	149247723	+	Missense_Mutation	SNP	A	A	C			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr2:149247723A>C	ENST00000407073.1	+	12	4820	c.3823A>C	c.(3823-3825)Agt>Cgt	p.S1275R	MBD5_ENST00000404807.1_Missense_Mutation_p.S1508R	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1275						chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		AACTATGATGAGTTTTAAGGA	0.423000													19	41					0	0	9.7654e-05	0	0
RAD54L2	23132	broad.mit.edu	37	3	51677967	51677967	+	Silent	SNP	C	C	T			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr3:51677967C>T	ENST00000409535.1	+	15	2552	c.2427C>T	c.(2425-2427)acC>acT	p.T809T	RAD54L2_ENST00000296477.3_Silent_p.T503T	NM_015106.2	NP_055921.2	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2 (S. cerevisiae)	809	Helicase C-terminal.					nucleus	ATP binding|DNA binding|helicase activity			NS(2)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|liver(2)|lung(9)|ovary(4)|skin(2)	31				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		ACCTCACCACCTGGCTGTTCC	0.527000													3	10					0	0	6.4e-05	0	0
KRTAP4-7	100132476	broad.mit.edu	37	17	39240627	39240627	+	Missense_Mutation	SNP	T	T	C	rs139671425	by1000genomes	TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr17:39240627T>C	ENST00000391417.4	+	1	169	c.169T>C	c.(169-171)Tct>Cct	p.S57P		NM_033061.3	NP_149050.3			keratin associated protein 4-7									p.S57P(4)		NS(1)|endometrium(3)|kidney(1)|lung(1)|prostate(2)|urinary_tract(1)	9						GTGCTGCCAGTCTGTGTGCTG	0.667000													3	24					0	0	8.12818e-05	0	0
SPDL1	54908	broad.mit.edu	37	5	169018183	169018183	+	Silent	SNP	A	A	G			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr5:169018183A>G	ENST00000265295.4	+	3	570	c.291A>G	c.(289-291)caA>caG	p.Q97Q	SPDL1_ENST00000510751.1_3'UTR	NM_017785.4	NP_060255.3			spindle apparatus coiled-coil protein 1																		TGGAAGAACAACTAAGCAGAA	0.378000													14	46					0	0	0.000219431	0	0
PCDHB4	56131	broad.mit.edu	37	5	140501880	140501880	+	Silent	SNP	G	G	A			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr5:140501880G>A	ENST00000194152.1	+	1	300	c.300G>A	c.(298-300)ccG>ccA	p.P100P		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		100	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTATTGAACCGTGTGTACTGC	0.463000													24	69					0	0	7.16444e-05	0	0
MYC	4609	broad.mit.edu	37	8	128750836	128750836	+	Missense_Mutation	SNP	A	A	T			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr8:128750836A>T	ENST00000377970.2	+	2	883	c.373A>T	c.(373-375)Atg>Ttg	p.M125L	MYC_ENST00000524013.1_Missense_Mutation_p.M124L|MYC_ENST00000259523.6_Missense_Mutation_p.M110L	NM_002467.4	NP_002458.2	P01106	MYC_HUMAN	v-myc avian myelocytomatosis viral oncogene homolog	110					branching involved in ureteric bud morphogenesis|cell cycle arrest|cell proliferation|cellular iron ion homeostasis|positive regulation of metanephric cap mesenchymal cell proliferation|positive regulation of transcription, DNA-dependent|regulation of telomere maintenance|regulation of transcription from RNA polymerase II promoter|response to drug	nucleolus|nucleoplasm	E-box binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|lung(7)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	16	all_cancers(1;6.19e-134)|all_epithelial(1;1.75e-119)|all_lung(1;5.66e-51)|Breast(1;1.08e-22)|all_neural(1;4.45e-21)|Medulloblastoma(1;1.88e-20)|Colorectal(1;1.92e-09)|Lung SC(1;4.52e-07)|Ovarian(5;0.000122)|Esophageal squamous(12;0.000995)|Renal(1;0.0921)|Hepatocellular(40;0.108)|Myeloproliferative disorder(2;0.135)|Melanoma(291;0.185)	Myeloproliferative disorder(644;0.0255)|Ovarian(118;0.0654)|Breast(495;0.212)|Acute lymphoblastic leukemia(644;0.22)	Epithelial(1;1.63e-94)|all cancers(1;5.82e-87)|OV - Ovarian serous cystadenocarcinoma(1;2.12e-71)|BRCA - Breast invasive adenocarcinoma(1;4.3e-14)|Lung(2;0.000381)|Colorectal(2;0.0102)|LUAD - Lung adenocarcinoma(14;0.0172)|READ - Rectum adenocarcinoma(2;0.0723)|LUSC - Lung squamous cell carcinoma(258;0.151)	KIRC - Kidney renal clear cell carcinoma(542;0.248)		GGGAGGAGACATGGTGAACCA	0.607000		3	"""A, T"""	"""IGK@, BCL5, BCL7A , BTG1, TRA@, IGH@"""	"""Burkitt lymphoma,  amplified in other cancers, B-CLL"""						OREG0018982	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	118					0	0	0.000132079	0	0
JMJD1C	221037	broad.mit.edu	37	10	64967657	64967657	+	Missense_Mutation	SNP	T	T	C			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr10:64967657T>C	ENST00000399262.2	-	10	3990	c.3772A>G	c.(3772-3774)Aaa>Gaa	p.K1258E	JMJD1C_ENST00000542921.1_Missense_Mutation_p.K1076E|JMJD1C_ENST00000399251.1_Missense_Mutation_p.K1039E|JMJD1C_ENST00000402544.1_Missense_Mutation_p.K1039E	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	1258					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					TGGGAGTCTTTTGGTTCGGGT	0.423000													24	61					0	0	5.49717e-05	0	0
AURKAIP1	54998	broad.mit.edu	37	1	1309511	1309511	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr1:1309511G>A	ENST00000338370.3	-	2	767	c.367C>T	c.(367-369)Cct>Tct	p.P123S	AURKAIP1_ENST00000321751.5_Missense_Mutation_p.P123S|AURKAIP1_ENST00000378853.3_Missense_Mutation_p.P123S|AURKAIP1_ENST00000338338.5_Missense_Mutation_p.P123S			Q9NWT8	AKIP_HUMAN	aurora kinase A interacting protein 1	123					negative regulation of mitosis|positive regulation of proteolysis	mitochondrion|nucleus	protein binding			kidney(1)|lung(2)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.82e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		TGAATTTGAGGCGCATCCGCG	0.617000													42	215					0	0	0.000374591	0	0
EPS8L1	54869	broad.mit.edu	37	19	55597520	55597520	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr19:55597520G>A	ENST00000201647.6	+	16	1666	c.1610G>A	c.(1609-1611)gGa>gAa	p.G537E	EPS8L1_ENST00000540810.1_Missense_Mutation_p.G473E|EPS8L1_ENST00000588359.1_Missense_Mutation_p.G223E|EPS8L1_ENST00000245618.5_Missense_Mutation_p.G410E|EPS8L1_ENST00000586329.1_Intron	NM_133180.2	NP_573441.2	Q8TE68	ES8L1_HUMAN	EPS8-like 1	537	Pro-rich.|SH3.					cytoplasm				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|prostate(1)	12			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		CCCTACCCCGGACCCCGGCTG	0.642000													12	90					0	0	0.000308642	0	0
OR1M1	125963	broad.mit.edu	37	19	9204217	9204217	+	Silent	SNP	C	C	T			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr19:9204217C>T	ENST00000429566.3	+	1	363	c.297C>T	c.(295-297)atC>atT	p.I99I		NM_001004456.1	NP_001004456.1	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M, member 1	99					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(17)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						GCTGCCTGATCCAGATGTACT	0.527000													8	73					0	0	0.000274275	0	0
DSG2	1829	broad.mit.edu	37	18	29111149	29111149	+	Missense_Mutation	SNP	G	G	C			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr18:29111149G>C	ENST00000261590.8	+	9	1423	c.1214G>C	c.(1213-1215)aGc>aCc	p.S405T		NM_001943.3	NP_001934.2	Q14126	DSG2_HUMAN	desmoglein 2	405	Cadherin 4.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(2)|prostate(4)|skin(2)|urinary_tract(1)	49			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			GATAGATCAAGCAAAGGCCAA	0.388000													17	62					0	0	0.000422831	0	0
SCN8A	6334	broad.mit.edu	37	12	52164343	52164343	+	Missense_Mutation	SNP	T	T	A			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr12:52164343T>A	ENST00000354534.5	+	19	3699	c.3521T>A	c.(3520-3522)gTc>gAc	p.V1174D	SCN8A_ENST00000545061.1_Missense_Mutation_p.V1174D	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	1174					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	TGCTGCCAGGTCAACATCGAG	0.587000													5	27					0	0	3.59834e-05	0	0
EPG5	57724	broad.mit.edu	37	18	43458346	43458346	+	Silent	SNP	G	G	A	rs150214973	by1000genomes	TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr18:43458346G>A	ENST00000282041.5	-	34	5971	c.5937C>T	c.(5935-5937)aaC>aaT	p.N1979N	EPG5_ENST00000585906.1_5'UTR	NM_020964.2	NP_066015.2	Q9HCE0	EPG5_HUMAN	ectopic P-granules autophagy protein 5 homolog (C. elegans)	1979					autophagy					NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						TTTACCTTTCGTTGTCCTCTA	0.328000													18	59					0	0	9.7654e-05	0	0
SERPIND1	3053	broad.mit.edu	37	22	21141316	21141316	+	Missense_Mutation	SNP	C	C	G			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr22:21141316C>G	ENST00000215727.5	+	5	1745	c.1462C>G	c.(1462-1464)Ctc>Gtc	p.L488V	PI4KA_ENST00000466162.1_Intron|SERPIND1_ENST00000406799.1_Missense_Mutation_p.L488V|PI4KA_ENST00000255882.6_Intron|PI4KA_ENST00000572273.1_Intron	NM_000185.3	NP_000176.2	P05546	HEP2_HUMAN	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	488					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	CAGCTGCCTGCTCTTCATGGG	0.572000													25	31					0	0	0.000184323	0	0
OR1M1	125963	broad.mit.edu	37	19	9204196	9204196	+	Silent	SNP	C	C	T			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr19:9204196C>T	ENST00000429566.3	+	1	342	c.276C>T	c.(274-276)atC>atT	p.I92I		NM_001004456.1	NP_001004456.1	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M, member 1	92					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(17)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						GCAAGGCCATCTCTTATCCCT	0.522000													7	62					0	0	0.000157383	0	0
ANKS6	203286	broad.mit.edu	37	9	101552847	101552847	+	Missense_Mutation	SNP	C	C	G			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr9:101552847C>G	ENST00000353234.4	-	2	448	c.401G>C	c.(400-402)gGg>gCg	p.G134A	ANKS6_ENST00000471846.1_5'UTR|ANKS6_ENST00000540940.1_5'UTR|ANKS6_ENST00000375018.1_Missense_Mutation_p.G134A|ANKS6_ENST00000375019.2_Intron			Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain containing 6	134										endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	21		Acute lymphoblastic leukemia(62;0.0527)				GACATCAGCCCCGTGATCCAA	0.597000													3	30					0	0	6.4e-05	0	0
HEMGN	55363	broad.mit.edu	37	9	100693159	100693159	+	Missense_Mutation	SNP	G	G	C			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr9:100693159G>C	ENST00000259456.3	-	4	661	c.518C>G	c.(517-519)tCt>tGt	p.S173C		NM_018437.3|NM_197978.2	NP_060907.2|NP_932095.1	Q9BXL5	HEMGN_HUMAN	hemogen	173					cell differentiation|multicellular organismal development					NS(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|skin(2)|urinary_tract(1)	27		Acute lymphoblastic leukemia(62;0.0559)				CATTTTAGGAGAGAGGTCTTC	0.373000													60	172					0	0	0.000147903	0	0
RPS6KA4	8986	broad.mit.edu	37	11	64132815	64132815	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr11:64132815C>T	ENST00000528057.1	+	9	1037	c.949C>T	c.(949-951)Cca>Tca	p.P317S	RPS6KA4_ENST00000334205.4_Missense_Mutation_p.P317S|RPS6KA4_ENST00000294261.4_Missense_Mutation_p.P317S	NM_001006944.1	NP_001006945.1	O75676	KS6A4_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 4	317	AGC-kinase C-terminal.				axon guidance|histone phosphorylation|interleukin-1-mediated signaling pathway|intracellular protein kinase cascade|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|magnesium ion binding|mitogen-activated protein kinase p38 binding|ribosomal protein S6 kinase activity			breast(1)|endometrium(3)|lung(7)|ovary(1)|prostate(1)	13						GATTCCAGCCCCATTCCGGCC	0.612000													14	26					0	0	0.000151284	0	0
NLRP2	55655	broad.mit.edu	37	19	55495050	55495050	+	Missense_Mutation	SNP	C	C	A			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr19:55495050C>A	ENST00000543010.1	+	6	2127	c.1984C>A	c.(1984-1986)Ctc>Atc	p.L662I	NLRP2_ENST00000537859.1_Missense_Mutation_p.L640I|NLRP2_ENST00000391721.4_Missense_Mutation_p.L638I|NLRP2_ENST00000339757.7_Missense_Mutation_p.L640I|NLRP2_ENST00000448584.2_Missense_Mutation_p.L662I|NLRP2_ENST00000427260.2_Missense_Mutation_p.L639I|NLRP2_ENST00000263437.6_Missense_Mutation_p.L659I|NLRP2_ENST00000538819.1_Missense_Mutation_p.L638I	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	662					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		AAAGGAGAATCTCCCGGAGAA	0.493000													46	42					8.94452e-30	3.62404e-28	0.000147903	1	0
OR4D2	124538	broad.mit.edu	37	17	56247914	56247914	+	Missense_Mutation	SNP	A	A	G			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr17:56247914A>G	ENST00000545221.1	+	1	898	c.898A>G	c.(898-900)Aga>Gga	p.R300G		NM_001004707.3	NP_001004707.1	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D, member 2	300					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(19)|ovary(1)|skin(2)|stomach(1)	26						AGCAGTGAGAAGATTAGGGAG	0.502000													33	141					0	0	0.000159656	0	0
POLR2I	5438	broad.mit.edu	37	19	36605705	36605705	+	Missense_Mutation	SNP	C	C	G			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr19:36605705C>G	ENST00000221859.4	-	1	543	c.54G>C	c.(52-54)caG>caC	p.Q18H		NM_006233.4	NP_006224.1	P36954	RPB9_HUMAN	polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa	18					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|zinc ion binding			kidney(1)|large_intestine(1)|ovary(1)	3	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CTCACCATTCCTGGCAGAAGC	0.657000													37	124					0	0	0.000319135	0	0
ZNF154	7710	broad.mit.edu	37	19	58213208	58213208	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr19:58213208G>A	ENST00000512439.2	-	3	1305	c.1109C>T	c.(1108-1110)tCc>tTc	p.S370F	ZNF154_ENST00000426889.1_Missense_Mutation_p.S370F|AC003006.7_ENST00000599221.1_Intron|AC003006.7_ENST00000596085.1_Intron			Q13106	ZN154_HUMAN	zinc finger protein 154	370						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(3)	12		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TCGGAGACTGGAGCTGTAGGG	0.488000													14	38					0	0	0.000151284	0	0
MCCC2	64087	broad.mit.edu	37	5	70888768	70888768	+	Missense_Mutation	SNP	A	A	G			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr5:70888768A>G	ENST00000340941.6	+	2	274	c.145A>G	c.(145-147)Atg>Gtg	p.M49V	MCCC2_ENST00000509358.2_Missense_Mutation_p.M49V|MCCC2_ENST00000323375.8_Missense_Mutation_p.M49V	NM_022132.4	NP_071415.1	Q9HCC0	MCCB_HUMAN	methylcrotonoyl-CoA carboxylase 2 (beta)	49					leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			endometrium(2)|kidney(15)|large_intestine(2)|lung(9)|ovary(1)|urinary_tract(1)	30		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)	CTACAAGCAGATGAAAGCACT	0.343000													13	73					0	0	0.000308642	0	0
BCMO1	53630	broad.mit.edu	37	16	81320964	81320964	+	Missense_Mutation	SNP	C	C	G			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr16:81320964C>G	ENST00000258168.2	+	10	1828	c.1367C>G	c.(1366-1368)gCg>gGg	p.A456G	BCMO1_ENST00000425577.2_Missense_Mutation_p.A387G	NM_017429.2	NP_059125.2	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase 1	456					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity			breast(2)|endometrium(1)|large_intestine(4)|lung(9)|prostate(3)|skin(3)|stomach(1)	23						TGCTGGCCAGCGGAACCCCTG	0.483000													19	27					0	0	0.000229342	0	0
BRINP3	339479	broad.mit.edu	37	1	190195425	190195425	+	Missense_Mutation	SNP	A	A	C			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr1:190195425A>C	ENST00000367462.3	-	6	979	c.748T>G	c.(748-750)Tat>Gat	p.Y250D	FAM5C_ENST00000534846.1_Missense_Mutation_p.Y148D|FAM5C_ENST00000484105.1_5'UTR	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		250						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					TCCTGAAGATAGTCTGGGAGA	0.338000													5	31					0	0	1.23904e-05	0	0
GABPB1	2553	broad.mit.edu	37	15	50601977	50601977	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr15:50601977C>A	ENST00000380877.3	-	2	442	c.19G>T	c.(19-21)Gga>Tga	p.G7*	GABPB1_ENST00000359031.4_Nonsense_Mutation_p.G7*|GABPB1_ENST00000220429.8_Nonsense_Mutation_p.G7*|GABPB1_ENST00000429662.2_Nonsense_Mutation_p.G7*|GABPB1_ENST00000543881.1_Intron|GABPB1_ENST00000560825.1_Nonsense_Mutation_p.G7*|GABPB1_ENST00000396464.3_Nonsense_Mutation_p.G7*	NM_005254.5|NM_016654.4	NP_005245.2|NP_057738.1	Q06547	GABP1_HUMAN	GA binding protein transcription factor, beta subunit 1	7					positive regulation of transcription from RNA polymerase II promoter	nucleus	protein binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			cervix(1)|endometrium(1)|large_intestine(7)|lung(5)	14						AGCTTCTTTCCCAAATCTACC	0.383000													16	1904					6.40141e-05	0.00242984	6.40141e-05	1	0
FOXA2	3170	broad.mit.edu	37	20	22564860	22564860	+	Silent	SNP	G	G	A			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr20:22564860G>A	ENST00000419308.2	-	1	241	c.39C>T	c.(37-39)tcC>tcT	p.S13S	FOXA2_ENST00000377115.4_Silent_p.S13S|FOXA2_ENST00000319993.4_Silent_p.S19S	NM_021784.4	NP_068556.2	Q9Y261	FOXA2_HUMAN	forkhead box A2	13					cell differentiation in hindbrain|central nervous system myelin formation|chromatin modification|dorsal/ventral neural tube patterning|ectoderm formation|endocrine pancreas development|endoderm development|epithelial tube branching involved in lung morphogenesis|in utero embryonic development|lung epithelial cell differentiation|negative regulation of neuron differentiation|neuron fate specification|oligodendrocyte cell fate commitment|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of neuron differentiation|primitive streak formation|regulation of blood coagulation|regulation of sequence-specific DNA binding transcription factor activity|response to interleukin-6	cytoplasm|transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(1)|lung(3)|ovary(2)|prostate(2)|urinary_tract(1)	22	Lung NSC(19;0.188)					TGCTCCAGTCGGACGGCTCGT	0.582000													15	41					0	0	7.07596e-05	0	0
C2CD3	26005	broad.mit.edu	37	11	73795951	73795951	+	Silent	SNP	T	T	C			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr11:73795951T>C	ENST00000334126.7	-	22	4201	c.3975A>G	c.(3973-3975)acA>acG	p.T1325T	C2CD3_ENST00000313663.7_Silent_p.T1325T			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1325						centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					GCAGCTCTTTTGTTGGAACTT	0.373000													17	782					0	0	9.7654e-05	0	0
NLK	51701	broad.mit.edu	37	17	26495492	26495492	+	Missense_Mutation	SNP	G	G	C			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr17:26495492G>C	ENST00000407008.3	+	6	1574	c.856G>C	c.(856-858)Gcc>Ccc	p.A286P		NM_016231.4	NP_057315.3	Q9UBE8	NLK_HUMAN	nemo-like kinase	286	Protein kinase.				intracellular protein kinase cascade|negative regulation of Wnt receptor signaling pathway|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|serine phosphorylation of STAT3 protein|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|MAP kinase activity|SH2 domain binding|transcription factor binding|ubiquitin protein ligase binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(1)	14	all_lung(13;0.000343)|Lung NSC(42;0.00184)			UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		TTTTGGATTGGCCAGAGTGGA	0.378000													36	268					0	0	0.000132358	0	0
MYT1	4661	broad.mit.edu	37	20	62871203	62871203	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr20:62871203G>A	ENST00000536311.1	+	22	3629	c.3265G>A	c.(3265-3267)Ggc>Agc	p.G1089S	MYT1_ENST00000328439.1_Missense_Mutation_p.G1062S			Q01538	MYT1_HUMAN	myelin transcription factor 1	1062				DA -> VP (in Ref. 5; AAA59897).	cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					GGAGCTGTCCGGCCTGAGCCA	0.592000													12	135					0	0	6.40141e-05	0	0
IRF6	3664	broad.mit.edu	37	1	209974733	209974733	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr1:209974733C>T	ENST00000367021.3	-	3	198	c.26G>A	c.(25-27)cGg>cAg	p.R9Q	IRF6_ENST00000542854.1_Intron	NM_006147.3	NP_006138.1	O14896	IRF6_HUMAN	interferon regulatory factor 6	9					cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|large_intestine(4)|lung(12)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	28				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		GGGCTTTAGCCGGACTCTGCG	0.597000										HNSCC(57;0.16)			18	145					0	0	0.000132079	0	0
CROCCP2	84809	broad.mit.edu	37	1	16946407	16946407	+	RNA	SNP	T	T	G	rs10796418	by1000genomes	TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr1:16946407T>G	ENST00000412962.1	-	0	1112																											AGCAATCTCCTCACTCAGCTG	0.672000													4	47					0	0	0.00024832	0	0
POTEC	388468	broad.mit.edu	37	18	14542693	14542693	+	Silent	SNP	C	C	T			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr18:14542693C>T	ENST00000358970.5	-	1	452	c.453G>A	c.(451-453)aaG>aaA	p.K151K	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	151								p.K151K(2)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						TTCTGGGGACCTTACCCCACC	0.592000													6	249					0	0	6.40141e-05	0	0
LILRA1	11024	broad.mit.edu	37	19	55112268	55112268	+	Missense_Mutation	SNP	C	C	G			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr19:55112268C>G	ENST00000453777.1	+	8	1026	c.856C>G	c.(856-858)Cag>Gag	p.Q286E	LILRB1_ENST00000418536.2_Intron|LILRA1_ENST00000251372.3_Missense_Mutation_p.Q486E|LILRB1_ENST00000396321.2_Intron|LILRB1_ENST00000448689.1_Intron|LILRA1_ENST00000473156.1_3'UTR	NM_001278318.1	NP_001265247.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	486	Ig-like C2-type 3.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		TCAGCACAGCCAGAGAAGCCT	0.552000													9	44					0	0	3.86212e-05	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33546309	33546309	+	Splice_Site	SNP	T	T	A			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr5:33546309T>A	ENST00000504830.1	-	22	4638		c.e22-2		ADAMTS12_ENST00000352040.3_Splice_Site	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12						proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						CCTGGAGCACTGATACACAGC	0.453000										HNSCC(64;0.19)			13	25					0	0	0.000308642	0	0
TENM4	26011	broad.mit.edu	37	11	78380400	78380400	+	Silent	SNP	G	G	T			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr11:78380400G>T	ENST00000278550.7	-	32	7452	c.6990C>A	c.(6988-6990)tcC>tcA	p.S2330S		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		TCTCAGAGCTGGAGTGGTTGT	0.552000													41	4029					0.000151284	0.00568262	0.000151284	1	0
KCTD21	283219	broad.mit.edu	37	11	77884952	77884952	+	Missense_Mutation	SNP	T	T	G			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr11:77884952T>G	ENST00000340067.3	-	2	927	c.649A>C	c.(649-651)Atc>Ctc	p.I217L	KCTD21-AS1_ENST00000600795.1_RNA|KCTD21-AS1_ENST00000523626.2_RNA	NM_001029859.1	NP_001025030.1	Q4G0X4	KCD21_HUMAN	potassium channel tetramerization domain containing 21	217						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|endometrium(1)|large_intestine(4)|lung(2)|pancreas(1)|prostate(2)	11	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.46e-24)			AAGCTGTTGATCTGCTTGTTG	0.542000													51	4198					0	0	3.86212e-05	0	0
PAAF1	80227	broad.mit.edu	37	11	73610247	73610247	+	Silent	SNP	C	C	T			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr11:73610247C>T	ENST00000544909.1	+	3	599	c.342C>T	c.(340-342)gaC>gaT	p.D114D	PAAF1_ENST00000535604.1_5'UTR|PAAF1_ENST00000310571.3_Silent_p.D113D|PAAF1_ENST00000536003.1_Silent_p.D96D|PAAF1_ENST00000543079.1_3'UTR|PAAF1_ENST00000544552.1_Silent_p.D96D|PAAF1_ENST00000376384.5_Silent_p.D96D|PAAF1_ENST00000541951.1_5'UTR			Q9BRP4	PAAF1_HUMAN	proteasomal ATPase-associated factor 1	113					interspecies interaction between organisms	proteasome complex	protein binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Breast(11;7.42e-05)					CTAGTACTGACGGGACCATGA	0.413000													11	887					0	0	2.17888e-05	0	0
VCX	26609	broad.mit.edu	37	X	7811760	7811760	+	Silent	SNP	C	C	T			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chrX:7811760C>T	ENST00000381059.3	+	3	543	c.324C>T	c.(322-324)gcC>gcT	p.A108A	VCX_ENST00000341408.4_Silent_p.A108A	NM_013452.2	NP_038480.2	Q9H320	VCX1_HUMAN	variable charge, X-linked	108	10 X 10 AA tandem repeats of L-S-Q-E-S- [EQ]-V-E-E-P.|Glu-rich.				chromatin organization|ribosome assembly|spermatogenesis	nucleolus	chromatin binding			NS(1)|endometrium(4)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	10		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)				GTCAGGAGGCCGAGCTGGAGG	0.662000													8	231					0	0	3.86212e-05	0	0
PNMA3	29944	broad.mit.edu	37	X	152225755	152225755	+	Missense_Mutation	SNP	C	C	T	rs146193731		TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chrX:152225755C>T	ENST00000447306.1	+	2	679	c.343C>T	c.(343-345)Cgg>Tgg	p.R115W	PNMA3_ENST00000370264.4_Missense_Mutation_p.R115W|PNMA3_ENST00000370265.4_Missense_Mutation_p.R115W	NM_013364.4	NP_037496.3	Q9UL41	PNMA3_HUMAN	paraneoplastic Ma antigen 3	115					apoptosis	nucleolus	nucleic acid binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	16	Acute lymphoblastic leukemia(192;6.56e-05)					ggaggagaggcggaccgtgtc	0.532000													24	18					0	0	0.000375601	0	0
CSK	1445	broad.mit.edu	37	15	75093892	75093892	+	Silent	SNP	G	G	A			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr15:75093892G>A	ENST00000220003.9	+	10	1572	c.843G>A	c.(841-843)agG>agA	p.R281R	CSK_ENST00000567571.1_Silent_p.R281R|CSK_ENST00000309470.9_Silent_p.R281R|CSK_ENST00000439220.2_Silent_p.R281R	NM_004383.2	NP_004374.1	P41240	CSK_HUMAN	c-src tyrosine kinase	281	Protein kinase.				blood coagulation|epidermal growth factor receptor signaling pathway|T cell costimulation|T cell receptor signaling pathway	centrosome|cytosol|Golgi apparatus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein C-terminus binding			central_nervous_system(1)|lung(2)	3						TGCGGTCTAGGGGTCGGTCAG	0.632000													13	79					0	0	0.000422831	0	0
TMCO2	127391	broad.mit.edu	37	1	40713708	40713709	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr1:40713708_40713709delTC	ENST00000372766.3	+	1	136_137	c.43_44delTC	c.(43-45)tfs	p.S15fs	TMCO2_ENST00000468258.1_Intron	NM_001008740.3	NP_001008740.1	Q7Z6W1	TMCO2_HUMAN	transmembrane and coiled-coil domains 2	15						integral to membrane				kidney(1)|large_intestine(3)|lung(1)|ovary(1)	6	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			CCTCTTAGAGTCTCTCTCTCTC	0.406													7	300	---	---	---	---					
TEKT4	150483	broad.mit.edu	37	2	95539829	95539830	+	Frame_Shift_Ins	INS	-	-	G	rs149873671		TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr2:95539829_95539830insG	ENST00000295201.4	+	3	826_827	c.689_690insG	c.(688-690)ctafs	p.L230fs	AC097374.2_ENST00000568768.1_RNA	NM_144705.2	NP_653306.1	Q8WW24	TEKT4_HUMAN	tektin 4	230					cell projection organization|microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule		p.P230P(1)		NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	28						CAGGCTCATCCGTACTCCACCA	0.663													8	113	---	---	---	---					
KCTD8	386617	broad.mit.edu	37	4	44450273	44450294	+	Frame_Shift_Del	DEL	GCAGCTCGCCCCGGCGCCGGGC	GCAGCTCGCCCCGGCGCCGGGC	-			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr4:44450273_44450294delGCAGCTCGCCCCGGCGCCGGGC	ENST00000360029.3	-	1	530_551	c.247_268delGCCCGGCGCCGGGGCGAGCTGC	c.(247-270)ccfs	p.ARRRGELP83fs		NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	83	BTB.					cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.R86L(1)		central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						CTGTCCCTGGGCAGCTcgccccggcgccgggcgccgccACGG	0.658										HNSCC(17;0.042)			9	100	---	---	---	---					
THSD7A	221981	broad.mit.edu	37	7	11871469	11871470	+	In_Frame_Ins	INS	-	-	GCAGCG			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr7:11871469_11871470insGCAGCG	ENST00000423059.3	-	1	354_355	c.103_104insCGCTGC	c.(103-105)cct>CGCTGCcct	p.34_35insRC		NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	34						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		cagcagcaggagcagcggcagc	0.772										HNSCC(18;0.044)			10	29	---	---	---	---					
DNAJB13	374407	broad.mit.edu	37	11	73676057	73676057	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr11:73676057delA	ENST00000339764.1	+	4	1220	c.469delA	c.(469-471)aafs	p.K158fs	DNAJB13_ENST00000537753.1_5'UTR|RP11-167N4.2_ENST00000537019.1_RNA|RP11-167N4.2_ENST00000540886.1_RNA	NM_153614.2	NP_705842.2	P59910	DJB13_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 13	158					apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding			large_intestine(3)|lung(2)	5	Breast(11;7.42e-05)					TGGCTGCACCAAAAAAATTAA	0.572											OREG0021218	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	861	---	---	---	---					
TSKU	25987	broad.mit.edu	37	11	76506673	76506675	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr11:76506673_76506675delCTG	ENST00000527881.1	+	2	1039_1041	c.13_15delCTG	c.(13-15)del	p.L9del	TSKU_ENST00000333090.4_In_Frame_Del_p.L9del			Q8WUA8	TSK_HUMAN	tsukushi, small leucine rich proteoglycan	9						extracellular region				NS(1)|large_intestine(4)|lung(6)|urinary_tract(1)	12	Ovarian(111;0.112)					GCCGTGGCCCCTGCTGCTGCTGC	0.616													15	398	---	---	---	---					
KCTD14	65987	broad.mit.edu	37	11	77734223	77734223	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr11:77734223delG	ENST00000353172.5	-	1	117	c.73delC	c.(73-75)ggfs	p.R25fs	KCTD14_ENST00000533144.1_Intron|NDUFC2-KCTD14_ENST00000530054.1_Intron|NDUFC2-KCTD14_ENST00000528251.1_Intron|RP11-7I15.4_ENST00000526730.1_RNA	NM_001203260.1|NM_001203262.1|NM_023930.3	NP_001190189.1|NP_001190191.1|NP_076419.2	Q9BQ13	KCD14_HUMAN	potassium channel tetramerization domain containing 14	25						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	15	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1e-24)			CGCCTGGGCCGGGGGGACTGG	0.687													9	2735	---	---	---	---					
CLIP1	6249	broad.mit.edu	37	12	122812690	122812691	+	Frame_Shift_Ins	INS	-	-	T			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr12:122812690_122812691insT	ENST00000358808.2	-	16	3173_3174	c.3019_3020insA	c.(3019-3021)ccafs	p.P1007fs	CLIP1_ENST00000302528.7_Frame_Shift_Ins_p.P1007fs|CLIP1_ENST00000540338.1_Frame_Shift_Ins_p.P1018fs|CLIP1_ENST00000537178.1_Frame_Shift_Ins_p.P972fs|CLIP1_ENST00000361654.4_Frame_Shift_Ins_p.P896fs|CLIP1_ENST00000545889.1_Frame_Shift_Ins_p.P593fs	NM_001247997.1|NM_002956.2	NP_001234926.1|NP_002947.1	P30622	CLIP1_HUMAN	CAP-GLY domain containing linker protein 1	1018					mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			NS(1)|breast(5)|endometrium(4)|kidney(5)|large_intestine(16)|liver(1)|lung(21)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		CTGGTTGTGGCTTGTTTCCATT	0.505													9	179	---	---	---	---					
EFTUD2	9343	broad.mit.edu	37	17	42929088	42929089	+	Frame_Shift_Ins	INS	-	-	G			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr17:42929088_42929089insG	ENST00000426333.2	-	27	3109_3110	c.2812_2813insC	c.(2812-2814)ccgfs	p.P938fs	EFTUD2_ENST00000592576.1_Frame_Shift_Ins_p.P928fs|EFTUD2_ENST00000591382.1_Frame_Shift_Ins_p.P938fs|EFTUD2_ENST00000402521.3_Frame_Shift_Ins_p.P903fs	NM_001142605.1|NM_001258354.1|NM_004247.3	NP_001136077.1|NP_001245283.1|NP_004238.3	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain containing 2	938						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	32		Prostate(33;0.109)				CTTCCTACGGCGGGTTTTGATC	0.559													5	10	---	---	---	---					
APOC1P1	342	broad.mit.edu	37	19	45431268	45431268	+	RNA	DEL	A	A	-			TCGA-ER-A19T-01A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1942d67-3c90-474e-9164-e76ddf9e335a	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr19:45431268delA	ENST00000574565.1	+	0	402					NR_028412.1																						GAACAGATTGAAAAAAAAAAC	0.527													2	4	---	---	---	---