Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HCAR2	338442	broad.mit.edu	37	12	123187263	123187263	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr12:123187263C>T	ENST00000328880.5	-	1	627	c.568G>A	c.(568-570)Gaa>Aaa	p.E190K	RP11-324E6.6_ENST00000543611.1_lincRNA|HCAR1_ENST00000356987.2_Intron	NM_177551.3	NP_808219.1	Q8TDS4	HCAR2_HUMAN	hydroxycarboxylic acid receptor 2	190					negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	15					Mepenzolate(DB04843)|Niacin(DB00627)	AACATGGCTTCGTGCCACTGG	0.552000													4	95					0	0	0.009096	0	0
MLIP	90523	broad.mit.edu	37	6	53986275	53986275	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:53986275C>T	ENST00000514921.1	+	2	207	c.94C>T	c.(94-96)Ctg>Ttg	p.L32L	MLIP_ENST00000358276.5_Silent_p.L26L|MLIP_ENST00000274897.5_Silent_p.L32L|MLIP_ENST00000509997.1_Intron|MLIP_ENST00000511744.1_3'UTR|MLIP_ENST00000370877.2_Intron|MLIP_ENST00000502396.1_Silent_p.L43L|MLIP_ENST00000370876.2_Intron			Q5VWP3	MLIP_HUMAN	muscular LMNA-interacting protein	32	Interaction with LMNA.					nuclear envelope|PML body	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(16)|ovary(8)|skin(4)|stomach(1)|urinary_tract(1)	34						AGCCAAACCTCTGATCTTCAC	0.408000													6	111					0	0	0.006214	0	0
DMC1	11144	broad.mit.edu	37	22	38917728	38917728	+	Splice_Site	SNP	A	A	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr22:38917728A>T	ENST00000216024.2	-	13	1114	c.836_splice	c.e13-1	p.F280_splice	DMC1_ENST00000428462.2_Splice_Site_p.F225_splice	NM_007068.2	NP_008999.2	Q14565	DMC1_HUMAN	DNA meiotic recombinase 1	280					reciprocal meiotic recombination	condensed nuclear chromosome	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			large_intestine(5)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11	Melanoma(58;0.0286)					TCTGCCTGAAAGCTGAATTAA	0.408000								Homologous recombination					8	80					0	0	0.003080	0	0
IGLV2-23	28813	broad.mit.edu	37	22	23040796	23040796	+	RNA	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr22:23040796C>T	ENST00000390306.2	+	0	406																											GGTTTCTAATCGCTTCTCTGG	0.537000													10	150					0	0	0.006214	0	0
IGHV1OR16-3	28313	broad.mit.edu	37	16	32070612	32070612	+	RNA	SNP	A	A	C			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr16:32070612A>C	ENST00000566806.1	-	0	499																											GGTCTCCTGCAAGGCTTCTGG	0.552000													3	50					0	0	0.004672	0	0
KALRN	8997	broad.mit.edu	37	3	124153237	124153237	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:124153237C>T	ENST00000360013.3	+	17	3034	c.2907C>T	c.(2905-2907)gcC>gcT	p.A969A	KALRN_ENST00000460856.1_Silent_p.A960A|KALRN_ENST00000240874.3_Silent_p.A969A	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	969					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						TGCTCCAGGCCGGCCACTACG	0.587000													4	41					0	0	0.009096	0	0
C1orf168	199920	broad.mit.edu	37	1	57216843	57216843	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:57216843G>A	ENST00000343433.6	-	9	1341	c.1261C>T	c.(1261-1263)Cag>Tag	p.Q421*	C1orf168_ENST00000484327.1_5'UTR	NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	421										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						TTGGTCATCTGAATTTTTTCA	0.458000													9	48					0	0	0.004482	0	0
DBH	1621	broad.mit.edu	37	9	136508583	136508583	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr9:136508583G>A	ENST00000393056.2	+	4	805	c.793G>A	c.(793-795)Gaa>Aaa	p.E265K		NM_000787.3	NP_000778.3	P09172	DOPO_HUMAN	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	265					hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(9)|liver(1)|lung(6)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	36				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	CCACCACATGGAAGTCTTCCA	0.657000													4	61					0	0	0.009096	0	0
CARD11	84433	broad.mit.edu	37	7	2987263	2987263	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:2987263C>T	ENST00000396946.4	-	3	569	c.166G>A	c.(166-168)Gat>Aat	p.D56N		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	56	CARD.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TCATCTTCATCCTGCTCATCA	0.547000			Mis		DLBCL								7	106					0	0	0.001984	0	0
CLEC14A	161198	broad.mit.edu	37	14	38724435	38724435	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:38724435C>T	ENST00000342213.2	-	1	1139	c.793G>A	c.(793-795)Gac>Aac	p.D265N		NM_175060.2	NP_778230.1	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	265	EGF-like.					integral to membrane	sugar binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		CCTCCCAAGTCGTCTAGGCAG	0.642000													9	128					0	0	0.008291	0	0
OR13C4	138804	broad.mit.edu	37	9	107288987	107288987	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr9:107288987G>A	ENST00000277216.3	-	1	503	c.504C>T	c.(502-504)ttC>ttT	p.F168F		NM_001001919.1	NP_001001919.1	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C, member 4	168					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(2)|lung(14)|skin(1)	18						TGTTCCCACAGAAAGGCCATC	0.388000													5	80					0	0	0.000602	0	0
DMBT1	1755	broad.mit.edu	37	10	124380767	124380767	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr10:124380767G>A	ENST00000338354.3	+	41	5198	c.5092G>A	c.(5092-5094)Ggc>Agc	p.G1698S	DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000344338.3_Missense_Mutation_p.G1688S|DMBT1_ENST00000330163.4_Missense_Mutation_p.G1070S|DMBT1_ENST00000368956.2_Missense_Mutation_p.G1070S|DMBT1_ENST00000368955.3_Missense_Mutation_p.G1688S|DMBT1_ENST00000368909.3_Missense_Mutation_p.G1698S			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1698	SRCR 13.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GTTTGGCCAGGGCTCAGGACC	0.612000													9	219					0	0	0.006214	0	0
SERPINI2	5276	broad.mit.edu	37	3	167189541	167189541	+	Missense_Mutation	SNP	C	C	T	rs147443553		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:167189541C>T	ENST00000476257.1	-	3	380	c.82G>A	c.(82-84)Gaa>Aaa	p.E28K	SERPINI2_ENST00000465031.1_5'UTR|SERPINI2_ENST00000471111.1_Missense_Mutation_p.E28K|SERPINI2_ENST00000264677.4_Missense_Mutation_p.E28K|SERPINI2_ENST00000461846.1_Missense_Mutation_p.E28K			O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin), member 2	28					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(20)|prostate(1)|skin(5)|urinary_tract(1)	41						ACTGCAAATTCGGTATTTTTT	0.368000													8	111					0	0	0.003080	0	0
LPPR1	54886	broad.mit.edu	37	9	104032238	104032238	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr9:104032238G>A	ENST00000374874.3	+	3	579	c.140G>A	c.(139-141)gGa>gAa	p.G47E	LPPR1_ENST00000395056.2_Missense_Mutation_p.G47E	NM_207299.1	NP_997182.1	Q8TBJ4	LPPR1_HUMAN		47						integral to membrane	catalytic activity										CATATCCAAGGATTCTTCTGT	0.502000													6	69					0	0	0.001168	0	0
TRIML1	339976	broad.mit.edu	37	4	189068016	189068016	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr4:189068016C>T	ENST00000332517.3	+	6	1037	c.897C>T	c.(895-897)ctC>ctT	p.L299L	TRIML1_ENST00000507581.1_3'UTR	NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	299	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding	p.L299L(2)		NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		ATGCCTATCTCGTGTTGTCGG	0.512000													11	168					0	0	0.001855	0	0
STON2	85439	broad.mit.edu	37	14	81744382	81744382	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:81744382G>A	ENST00000555447.1	-	6	1685	c.1273C>T	c.(1273-1275)Cgt>Tgt	p.R425C	STON2_ENST00000267540.2_Missense_Mutation_p.R425C	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	425					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		CACCCGTCACGAGGCTGGGAC	0.532000													5	118					0	0	0.000602	0	0
PAX4	5078	broad.mit.edu	37	7	127253547	127253547	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:127253547C>T	ENST00000341640.2	-	5	783	c.578G>A	c.(577-579)gGa>gAa	p.G193E	PAX4_ENST00000463946.1_Missense_Mutation_p.G191E|PAX4_ENST00000338516.3_Missense_Mutation_p.G201E|PAX4_ENST00000378740.2_Missense_Mutation_p.G193E	NM_006193.2	NP_006184.2	O43316	PAX4_HUMAN	paired box 4	201					cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|kidney(2)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						AGCCAGCTTTCCACGGGCCAC	0.592000													4	64					0	0	0.009096	0	0
TRAV5	28688	broad.mit.edu	37	14	22217916	22217916	+	RNA	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:22217916G>A	ENST00000390427.3	+	0	279																											TGAATAAAAAGGATAAACATC	0.433000													4	53					0	0	0.009096	0	0
MYH4	4622	broad.mit.edu	37	17	10348440	10348440	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:10348440C>T	ENST00000255381.2	-	37	5429	c.5319G>A	c.(5317-5319)ctG>ctA	p.L1773L	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1773					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						GTTCCTTCTTCAGCTCCTCAG	0.493000													6	139					0	0	0.003080	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33561224	33561224	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr5:33561224C>T	ENST00000504830.1	-	20	4368	c.4033G>A	c.(4033-4035)Gat>Aat	p.D1345N	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.D1260N	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1345	TSP type-1 5.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						CAGTCAGAATCCATCTGGGTG	0.572000										HNSCC(64;0.19)			4	78					0	0	0.009096	0	0
AGPAT5	55326	broad.mit.edu	37	8	6599221	6599221	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr8:6599221C>T	ENST00000285518.6	+	5	847	c.535C>T	c.(535-537)Cca>Tca	p.P179S	AGPAT5_ENST00000530716.1_3'UTR	NM_018361.3	NP_060831.2	Q9NUQ2	PLCE_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 5	179					phospholipid biosynthetic process	integral to membrane|mitochondrion	1-acylglycerol-3-phosphate O-acyltransferase activity		AGPAT5/MCPH1(2)	endometrium(2)|kidney(2)|large_intestine(4)|lung(3)	11			STAD - Stomach adenocarcinoma(24;0.0578)	READ - Rectum adenocarcinoma(644;0.156)|COAD - Colon adenocarcinoma(149;0.191)		AAGGTATAATCCAGAGCAAAC	0.338000													5	120					0	0	0.001168	0	0
SYN3	8224	broad.mit.edu	37	22	32914039	32914039	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr22:32914039G>A	ENST00000358763.2	-	13	1843	c.1601C>T	c.(1600-1602)cCg>cTg	p.P534L	SYN3_ENST00000332840.5_Missense_Mutation_p.P534L|SYN3_ENST00000467095.1_5'UTR	NM_001135774.1	NP_001129246.1	O14994	SYN3_HUMAN	synapsin III	534	E.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						CTTGAGATGCGGATGGGGTGG	0.577000													4	102					0	0	0.001984	0	0
SUN5	140732	broad.mit.edu	37	20	31571702	31571702	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr20:31571702C>T	ENST00000356173.3	-	13	1130	c.1038G>A	c.(1036-1038)tgG>tgA	p.W346*	SUN5_ENST00000375523.3_Nonsense_Mutation_p.W321*	NM_080675.3	NP_542406.2	Q8TC36	SUN5_HUMAN	Sad1 and UNC84 domain containing 5	346	SUN.				spermatogenesis					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	25						CTGGGTTCCCCCAGTTGCTTG	0.597000													10	117					0	0	0.008291	0	0
ZNF180	7733	broad.mit.edu	37	19	44980972	44980972	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:44980972G>A	ENST00000221327.4	-	5	2007	c.1726C>T	c.(1726-1728)Ccg>Tcg	p.P576S	ZNF180_ENST00000592529.1_Missense_Mutation_p.P549S|ZNF180_ENST00000391956.4_Missense_Mutation_p.P551S	NM_013256.3	NP_037388.2	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	576					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(14)|lung(6)|ovary(2)|urinary_tract(1)	33		Prostate(69;0.0435)				CATTCATACGGTTTTTCCCCA	0.408000													6	68					0	0	0.001168	0	0
CLIC2	1193	broad.mit.edu	37	X	154507273	154507273	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:154507273G>A	ENST00000369449.2	-	6	881	c.663C>T	c.(661-663)gcC>gcT	p.A221A	CLIC2_ENST00000465553.1_5'UTR	NM_001289.4	NP_001280.3	O15247	CLIC2_HUMAN	chloride intracellular channel 2	221	C-terminal.|GST C-terminal.				signal transduction	chloride channel complex|cytoplasm|nucleus	voltage-gated chloride channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)	18	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ATTCTTCACGGGCATAGGCAT	0.408000													7	42					0	0	0.003080	0	0
IWS1	55677	broad.mit.edu	37	2	128253686	128253686	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:128253686C>T	ENST00000295321.4	-	7	1863	c.1604G>A	c.(1603-1605)cGa>cAa	p.R535Q	IWS1_ENST00000455721.2_3'UTR|AC010976.2_ENST00000599001.1_RNA	NM_017969.2	NP_060439.2	Q96ST2	IWS1_HUMAN	IWS1 homolog (S. cerevisiae)	535					transcription, DNA-dependent	nucleus	DNA binding			cervix(1)|endometrium(2)|kidney(6)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	28	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		GCTCTTTTTTCGCTGCAACAT	0.413000													10	185					0	0	0.006214	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117431534	117431534	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:117431534G>A	ENST00000160373.3	-	4	1807	c.1716C>T	c.(1714-1716)gcC>gcT	p.A572A		NM_033427.2	NP_219499.1	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	572										breast(3)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(36)|ovary(4)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		CTGTGTTCGAGGCCCTGCTGC	0.507000													5	98					0	0	0.000602	0	0
OR2B11	127623	broad.mit.edu	37	1	247614447	247614447	+	Missense_Mutation	SNP	G	G	A	rs113868131		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:247614447G>A	ENST00000318749.6	-	1	861	c.838C>T	c.(838-840)Ctc>Ttc	p.L280F		NM_001004492.1	NP_001004492.1	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B, member 11	280					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(13)|large_intestine(7)|lung(31)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	60	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GAATAGAAGAGAGAAATAAAT	0.493000													8	155					0	0	0.004482	0	0
ATXN1	6310	broad.mit.edu	37	6	16326840	16326840	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:16326840G>A	ENST00000244769.4	-	8	2638	c.1702C>T	c.(1702-1704)Cct>Tct	p.P568S	ATXN1_ENST00000436367.1_Missense_Mutation_p.P568S	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	568	AXH.|Interaction with USP7.|RNA-binding.|Self-association.				cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				GGCAGCGTAGGGGGAGCCGCC	0.612000													4	75					0	0	0.009096	0	0
CHRM5	1133	broad.mit.edu	37	15	34356204	34356204	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:34356204G>A	ENST00000383263.5	+	3	1956	c.1286G>A	c.(1285-1287)cGa>cAa	p.R429Q	CHRM5_ENST00000557872.1_Missense_Mutation_p.R429Q	NM_012125.3	NP_036257.1	P08912	ACM5_HUMAN	cholinergic receptor, muscarinic 5	429					cell proliferation|inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|skin(1)	20		all_lung(180;1.76e-08)		all cancers(64;4.82e-17)|GBM - Glioblastoma multiforme(113;2.58e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0262)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)	ATGACCAAACGAAAGAGAGTG	0.522000													6	53					0	0	0.001984	0	0
GHDC	84514	broad.mit.edu	37	17	40343146	40343146	+	Silent	SNP	G	G	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:40343146G>T	ENST00000301671.8	-	5	1413	c.972C>A	c.(970-972)ctC>ctA	p.L324L	GHDC_ENST00000414034.3_Silent_p.L324L|GHDC_ENST00000587427.1_Silent_p.L324L|GHDC_ENST00000436923.2_Silent_p.L324L|GHDC_ENST00000428494.2_Silent_p.L285L|GHDC_ENST00000593209.1_Silent_p.L324L			Q8N2G8	GHDC_HUMAN	GH3 domain containing	324						endoplasmic reticulum|nuclear envelope				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		all_cancers(22;0.000229)|Breast(137;0.00104)|all_epithelial(22;0.00304)		BRCA - Breast invasive adenocarcinoma(366;0.124)		CCTTGACTGGGAGCAGCTCGA	0.637000													7	82					0.00448238	0.0048885	0.004482	1	0
TCHHL1	126637	broad.mit.edu	37	1	152059079	152059079	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:152059079G>A	ENST00000368806.1	-	3	1143	c.1079C>T	c.(1078-1080)tCt>tTt	p.S360F		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	360							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TTGGGTCTCAGATGTTCTGCC	0.423000													7	212					0	0	0.001984	0	0
GPR42	2866	broad.mit.edu	37	19	35862375	35862375	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:35862375C>T	ENST00000454971.1	+	2	315	c.114C>T	c.(112-114)gtC>gtT	p.V38V	GPR42_ENST00000597214.1_Silent_p.V38V					G protein-coupled receptor 42 (gene/pseudogene)											endometrium(1)|kidney(1)|skin(2)	4	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;1.29e-19)|OV - Ovarian serous cystadenocarcinoma(14;4.63e-18)|all cancers(14;5.19e-17)|LUSC - Lung squamous cell carcinoma(66;0.0221)			CCCTGGTGGTCTTCGTGGGCA	0.642000													5	52					0	0	0.001984	0	0
TENM1	10178	broad.mit.edu	37	X	123805562	123805562	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:123805562C>T	ENST00000422452.2	-	6	1202	c.1139G>A	c.(1138-1140)gGa>gAa	p.G380E	TENM1_ENST00000371130.3_Missense_Mutation_p.G380E	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		AGAAACTTTTCCTCCAATTGG	0.403000													4	61					0	0	0.009096	0	0
RGPD8	727851	broad.mit.edu	37	2	113147662	113147662	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:113147662G>A	ENST00000302558.3	-	20	3051	c.2860C>T	c.(2860-2862)Cgg>Tgg	p.R954W	RGPD8_ENST00000409750.1_Missense_Mutation_p.R814W	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8											endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						CCCTTCTTCCGGCCCCTAATA	0.413000													10	259					0	0	0.006214	0	0
PLG	5340	broad.mit.edu	37	6	161162437	161162437	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:161162437G>A	ENST00000308192.9	+	17	2176	c.2113G>A	c.(2113-2115)Gga>Aga	p.G705R		NM_000301.3	NP_000292.1	P00747	PLMN_HUMAN	plasminogen	705	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)	59				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	CACTGGCTGGGGAGAAACCCA	0.458000													5	50					0	0	0.001168	0	0
DCLK3	85443	broad.mit.edu	37	3	36779592	36779592	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:36779592G>A	ENST00000416516.2	-	2	1049	c.559C>T	c.(559-561)Ccc>Tcc	p.P187S		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	187						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						TTTGCCTCGGGAGACCTCCTG	0.592000													5	80					0	0	0.000602	0	0
RPAP1	26015	broad.mit.edu	37	15	41812679	41812679	+	Silent	SNP	G	G	C			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:41812679G>C	ENST00000304330.4	-	22	3821	c.3705C>G	c.(3703-3705)ccC>ccG	p.P1235P	RPAP1_ENST00000561603.1_Intron	NM_015540.2	NP_056355.2	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	1235	Leu-rich.					nucleus	DNA binding|DNA-directed RNA polymerase activity			NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	45		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GACGCTGCAGGGGCAGGAGGA	0.592000													3	24					0	0	0.004672	0	0
CASP10	843	broad.mit.edu	37	2	202074268	202074268	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:202074268G>A	ENST00000286186.6	+	9	1833	c.1398G>A	c.(1396-1398)ctG>ctA	p.L466L	CASP10_ENST00000448480.1_Silent_p.L423L|CASP10_ENST00000272879.5_Silent_p.L466L|CASP10_ENST00000492363.1_3'UTR|CASP10_ENST00000360132.3_3'UTR|CASP10_ENST00000313728.7_Silent_p.L399L|CASP10_ENST00000346817.5_Silent_p.L423L	NM_032977.3	NP_116759.2	Q92851	CASPA_HUMAN	caspase 10, apoptosis-related cysteine peptidase	466					apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27						GTAATCATCTGAAGAAATTGG	0.388000													6	107					0	0	0.003080	0	0
SYTL5	94122	broad.mit.edu	37	X	37893191	37893191	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:37893191G>A	ENST00000357972.5	+	2	595	c.49G>A	c.(49-51)Gag>Aag	p.E17K	SYTL5_ENST00000297875.2_Missense_Mutation_p.E17K|SYTL5_ENST00000456733.2_Missense_Mutation_p.E17K|TM4SF2_ENST00000465127.1_Intron			Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5	17	RabBD.				intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	44						ATTAGATCATGAGAAGGAAAT	0.373000													4	25					0	0	0.009096	0	0
MDN1	23195	broad.mit.edu	37	6	90372576	90372576	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:90372576C>T	ENST00000369393.3	-	86	14462	c.14347G>A	c.(14347-14349)Gat>Aat	p.D4783N	MDN1_ENST00000428876.1_Missense_Mutation_p.D4783N			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	4783			D -> E (in dbSNP:rs36040566).		protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		tcctcctcatcATCATCACCC	0.458000													7	133					0	0	0.001984	0	0
RIMKLA	284716	broad.mit.edu	37	1	42875708	42875708	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:42875708C>T	ENST00000431473.3	+	4	664	c.535C>T	c.(535-537)Ctg>Ttg	p.L179L		NM_173642.3	NP_775913.2	Q8IXN7	RIMKA_HUMAN	ribosomal modification protein rimK-like family member A	179	ATP-grasp.				protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	13						CATCTGCCATCTGATCCGCCA	0.507000													13	117					0	0	0.004007	0	0
KRTAP13-1	140258	broad.mit.edu	37	21	31768434	31768434	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr21:31768434C>T	ENST00000355459.2	+	1	43	c.30C>T	c.(28-30)ttC>ttT	p.F10F		NM_181599.2	NP_853630.2	Q8IUC0	KR131_HUMAN	keratin associated protein 13-1	10						intermediate filament				endometrium(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CTGGAAACTTCTCCTCCCGCT	0.537000													6	190					0	0	0.001984	0	0
FGF16	8823	broad.mit.edu	37	X	76711796	76711796	+	Missense_Mutation	SNP	G	G	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:76711796G>T	ENST00000439435.1	+	2	133	c.133G>T	c.(133-135)Ggg>Tgg	p.G45W				O43320	FGF16_HUMAN	fibroblast growth factor 16	0					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|metabolic process|organ morphogenesis|response to temperature stimulus	extracellular space	growth factor activity			NS(1)|breast(1)|lung(2)	4						TGTGTTTTCCGGGAACAGTTT	0.428000													4	68					2.56e-06	2.82513e-06	0.009096	1	0
FLG2	388698	broad.mit.edu	37	1	152329730	152329730	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:152329730G>A	ENST00000388718.5	-	3	604	c.532C>T	c.(532-534)Cag>Tag	p.Q178*	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	178	Ser-rich.						calcium ion binding|structural molecule activity	p.Q178*(1)		NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TATCTTTTCTGAGATCCCTCT	0.478000													6	188					0	0	0.001984	0	0
OR4Q3	441669	broad.mit.edu	37	14	20216314	20216314	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:20216314C>T	ENST00000331723.1	+	1	728	c.728C>T	c.(727-729)tCt>tTt	p.S243F		NM_172194.1	NP_751944.1	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q, member 3	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(4)|endometrium(3)|kidney(2)|large_intestine(1)|lung(28)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ACCTGTGCTTCTCACCTGACA	0.463000													5	209					0	0	0.000602	0	0
FCHSD2	9873	broad.mit.edu	37	11	72600875	72600875	+	Splice_Site	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr11:72600875C>T	ENST00000409314.1	-	12	1280	c.1113_splice	c.e12+1	p.R371_splice	FCHSD2_ENST00000409853.1_Splice_Site_p.R291_splice|FCHSD2_ENST00000409418.4_Splice_Site_p.R347_splice|FCHSD2_ENST00000458644.2_Splice_Site_p.R211_splice|FCHSD2_ENST00000311172.7_Splice_Site_p.R291_splice			O94868	FCSD2_HUMAN	FCH and double SH3 domains 2	347							protein binding			endometrium(2)|large_intestine(11)|lung(5)|ovary(2)|prostate(1)|skin(1)	22			BRCA - Breast invasive adenocarcinoma(5;3.3e-05)			TACACTTACCCGTTGTTGGTG	0.398000													11	376					0	0	0.010729	0	0
KRTAP3-2	83897	broad.mit.edu	37	17	39155950	39155950	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:39155950G>A	ENST00000391587.1	-	1	188	c.156C>T	c.(154-156)ccC>ccT	p.P52P		NM_031959.2	NP_114165.1	Q9BYR7	KRA32_HUMAN	keratin associated protein 3-2	52	3 X 5 AA repeats of C-C-X(3).					keratin filament	structural molecule activity			endometrium(1)|large_intestine(1)|lung(1)	3		Breast(137;0.00043)				GGCAGGGTGGGGGACAGTTGT	0.617000													4	63					0	0	0.000602	0	0
NOTCH2	4853	broad.mit.edu	37	1	120458308	120458308	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:120458308G>A	ENST00000256646.2	-	34	7256	c.7037C>T	c.(7036-7038)gCc>gTc	p.A2346V		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	2346					anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGGCAAACGGGCCATTTCTGG	0.627000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				20	523					0	0	0.010504	0	0
HOXB5	3215	broad.mit.edu	37	17	46669655	46669655	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:46669655G>A	ENST00000239151.5	-	2	1004	c.726C>T	c.(724-726)ttC>ttT	p.F242F	HOXB3_ENST00000552000.2_Intron|HOXB-AS3_ENST00000467155.2_RNA|HOXB-AS3_ENST00000476204.1_RNA|HOXB-AS3_ENST00000480872.1_RNA|HOXB-AS3_ENST00000474040.1_RNA|HOXB-AS3_ENST00000465846.2_RNA|HOXB-AS3_ENST00000429755.4_RNA	NM_002147.3	NP_002138.1	P09067	HXB5_HUMAN	homeobox B5	242						nucleus	sequence-specific DNA binding			large_intestine(1)|lung(2)	3						GCCGGTTCTGGAACCAGATCT	0.592000													6	129					0	0	0.004482	0	0
OR12D2	26529	broad.mit.edu	37	6	29364501	29364501	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:29364501G>A	ENST00000383555.2	+	1	86	c.25G>A	c.(25-27)Gaa>Aaa	p.E9K	OR5V1_ENST00000377154.1_Intron	NM_013936.3	NP_039224.2	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)	9					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E9K(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	31						CTCAGTCACCGAATTTCTCCT	0.433000													14	198					0	0	0.004990	0	0
NUP210L	91181	broad.mit.edu	37	1	154076521	154076521	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:154076521C>T	ENST00000368559.3	-	13	1857	c.1786G>A	c.(1786-1788)Gat>Aat	p.D596N	NUP210L_ENST00000271854.3_Missense_Mutation_p.D596N	NM_207308.2	NP_997191.2	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like	596						integral to membrane				NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			CCTTGTTTATCCATGTTCAGA	0.343000													5	71					0	0	0.000602	0	0
MFSD6	54842	broad.mit.edu	37	2	191301840	191301840	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:191301840C>T	ENST00000392328.1	+	3	1409	c.1085C>T	c.(1084-1086)cCc>cTc	p.P362L	MFSD6_ENST00000281416.7_Missense_Mutation_p.P362L	NM_017694.3	NP_060164.3	Q6ZSS7	MFSD6_HUMAN	major facilitator superfamily domain containing 6	362					transmembrane transport	integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(3)|stomach(1)	23						GGGTGTAAGCCCCCCGAGTAC	0.572000													4	32					0	0	0.009096	0	0
MYD88	4615	broad.mit.edu	37	3	38182688	38182688	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:38182688C>T	ENST00000417037.2	+	5	1049	c.865C>T	c.(865-867)Ctg>Ttg	p.L289L	MYD88_ENST00000495303.1_3'UTR|MYD88_ENST00000424893.1_Silent_p.L236L|MYD88_ENST00000481122.1_3'UTR|MYD88_ENST00000396334.3_Silent_p.L281L|MYD88_ENST00000443433.2_3'UTR	NM_001172567.1	NP_001166038.1	Q99836	MYD88_HUMAN	myeloid differentiation primary response 88	268	TIR.				3'-UTR-mediated mRNA stabilization|anti-apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-17 production|positive regulation of interleukin-23 production|positive regulation of interleukin-6 production|regulation of inflammatory response|response to interleukin-1|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|intrinsic to membrane|plasma membrane	death receptor binding|TIR domain binding|transmembrane receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(226)|large_intestine(3)|lung(6)|upper_aerodigestive_tract(1)	237				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CCCCAGCATCCTGAGGTTCAT	0.557000			Mis		ABC-DLBCL								7	112					0	0	0.001984	0	0
MFNG	4242	broad.mit.edu	37	22	37876307	37876307	+	Missense_Mutation	SNP	G	G	A	rs146256245	byFrequency	TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr22:37876307G>A	ENST00000356998.3	-	3	558	c.335C>T	c.(334-336)gCg>gTg	p.A112V	MFNG_ENST00000416983.3_Missense_Mutation_p.A98V	NM_002405.3	NP_002396.2	O00587	MFNG_HUMAN	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	112					pattern specification process	extracellular space|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			large_intestine(2)|lung(2)|skin(1)	5	Melanoma(58;0.0574)					GCTGTGTTCCGCGGAGCAGTT	0.597000													10	49					0	0	0.008291	0	0
SCN1A	6323	broad.mit.edu	37	2	166848405	166848405	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:166848405C>T	ENST00000423058.2	-	26	5397	c.5380G>A	c.(5380-5382)Gaa>Aaa	p.E1794K	SCN1A_ENST00000303395.4_Missense_Mutation_p.E1794K|SCN1A_ENST00000375405.3_Missense_Mutation_p.E1783K|AC010127.3_ENST00000597623.1_RNA|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Missense_Mutation_p.E1766K	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1794						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GCACTTTCTTCAGTAGCAACA	0.418000													7	95					0	0	0.001984	0	0
HRNR	388697	broad.mit.edu	37	1	152192203	152192203	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:152192203G>A	ENST00000368801.2	-	3	1977	c.1902C>T	c.(1900-1902)tcC>tcT	p.S634S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	634					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACCGTGGCTGGAAGACTGAC	0.577000													12	336					0	0	0.001855	0	0
NPSR1	387129	broad.mit.edu	37	7	34888237	34888237	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:34888237C>T	ENST00000360581.1	+	8	1115	c.987C>T	c.(985-987)atC>atT	p.I329I	NPSR1_ENST00000381542.1_Silent_p.I263I|NPSR1_ENST00000381539.3_Silent_p.I329I|NPSR1_ENST00000531252.1_Silent_p.I318I|NPSR1_ENST00000359791.1_Silent_p.I329I	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	329						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	ACCCCCTCATCTACTGTGTCT	0.517000													7	154					0	0	0.003080	0	0
CDK19	23097	broad.mit.edu	37	6	110942464	110942464	+	Missense_Mutation	SNP	C	C	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:110942464C>A	ENST00000368911.3	-	12	1399	c.1220G>T	c.(1219-1221)gGg>gTg	p.G407V	CDK19_ENST00000323817.3_Missense_Mutation_p.G347V|CDK19_ENST00000413605.2_Missense_Mutation_p.G283V	NM_015076.3	NP_055891.1	Q9BWU1	CDK19_HUMAN	cyclin-dependent kinase 19	407							ATP binding|cyclin-dependent protein kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)	22						ACCTGCGGTCCCGTTGGTCTG	0.682000													9	92					0.000274275	0.000301147	0.004482	1	0
SCN11A	11280	broad.mit.edu	37	3	38968340	38968340	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:38968340G>A	ENST00000450244.1	-	4	769	c.571C>T	c.(571-573)Ctt>Ttt	p.L191F	SCN11A_ENST00000456224.3_Missense_Mutation_p.L191F|SCN11A_ENST00000444237.2_Missense_Mutation_p.L191F|SCN11A_ENST00000302328.3_Missense_Mutation_p.L191F			Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	191					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GGATCTCGAAGGAAAGAAAAC	0.368000													5	122					0	0	0.000602	0	0
QSOX1	5768	broad.mit.edu	37	1	180159627	180159627	+	Missense_Mutation	SNP	C	C	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:180159627C>A	ENST00000367602.3	+	10	1274	c.1200C>A	c.(1198-1200)ttC>ttA	p.F400L	QSOX1_ENST00000367600.5_Missense_Mutation_p.F400L			O00391	QSOX1_HUMAN	quiescin Q6 sulfhydryl oxidase 1	400	ERV/ALR sulfhydryl oxidase.				cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						AGCCGCATTTCCGGGGCTTTC	0.562000													5	115					0.000602214	0.000658989	0.000602	1	0
SLCO3A1	28232	broad.mit.edu	37	15	92663826	92663826	+	Missense_Mutation	SNP	A	A	G			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:92663826A>G	ENST00000318445.6	+	5	1355	c.1141A>G	c.(1141-1143)Aac>Gac	p.N381D	SLCO3A1_ENST00000424469.2_Missense_Mutation_p.N381D|SLCO3A1_ENST00000555549.1_3'UTR	NM_013272.3	NP_037404.2	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family, member 3A1	381					sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	25	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			GCAGCAGTTTAACCTCACCAC	0.562000													8	198					0	0	0.003080	0	0
TNXB	7148	broad.mit.edu	37	6	32029231	32029231	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:32029231G>A	ENST00000375244.3	-	21	7636	c.7435C>T	c.(7435-7437)Ctg>Ttg	p.L2479L	TNXB_ENST00000375247.2_Silent_p.L2479L			P22105	TENX_HUMAN	tenascin XB	2539	Fibronectin type-III 17.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						AGGCCATACAGGTGCATCTTG	0.672000													16	383					0	0	0.004990	0	0
RGPD3	653489	broad.mit.edu	37	2	107050819	107050819	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:107050819C>T	ENST00000409886.3	-	15	2157	c.2070G>A	c.(2068-2070)agG>agA	p.R690R	RGPD3_ENST00000304514.7_Silent_p.R690R	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	690					intracellular transport		binding			breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						CTTCTGCCTTCCTGTGAAAAA	0.368000													4	86					0	0	0.001168	0	0
PEAK1	79834	broad.mit.edu	37	15	77407096	77407096	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:77407096G>A	ENST00000560626.2	-	7	5118	c.4643C>T	c.(4642-4644)cCc>cTc	p.P1548L	PEAK1_ENST00000312493.4_Missense_Mutation_p.P1548L			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	1548	Protein kinase.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										AAGCCTAGTGGGATAAGATGA	0.592000													4	82					0	0	0.009096	0	0
MEP1A	4224	broad.mit.edu	37	6	46797217	46797217	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:46797217G>A	ENST00000230588.4	+	10	1062	c.1053G>A	c.(1051-1053)acG>acA	p.T351T		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	351	MAM.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			ATAAAATGACGGGAAGTCCTT	0.517000													9	158					0	0	0.004482	0	0
PCDH18	54510	broad.mit.edu	37	4	138450896	138450896	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr4:138450896G>A	ENST00000344876.4	-	1	2733	c.2347C>T	c.(2347-2349)Cct>Tct	p.P783S	PCDH18_ENST00000412923.2_Missense_Mutation_p.P783S|PCDH18_ENST00000507846.1_Missense_Mutation_p.P563S|PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000510305.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	783					brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					TCTAAGGTAGGAGATGAAGAT	0.507000													5	44					0	0	0.001168	0	0
LRRC7	57554	broad.mit.edu	37	1	70504196	70504196	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:70504196C>T	ENST00000310961.5	+	22	3008	c.2590C>T	c.(2590-2592)Cct>Tct	p.P864S	LRRC7_ENST00000415775.2_Missense_Mutation_p.P143S|LRRC7_ENST00000035383.5_Missense_Mutation_p.P859S			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	859						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						GACCGCTTTTCCTTCCAAATT	0.468000													4	79					0	0	0.009096	0	0
OR56A4	120793	broad.mit.edu	37	11	6023370	6023370	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr11:6023370G>A	ENST00000330728.4	-	1	1054	c.1009C>T	c.(1009-1011)Ctc>Ttc	p.L337F		NM_001005179.2	NP_001005179.2	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A, member 4	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|skin(1)|urinary_tract(1)	32		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGGGAATGAGGTGGTGCAGG	0.498000													4	58					0	0	0.009096	0	0
SMTNL2	342527	broad.mit.edu	37	17	4496341	4496341	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:4496341G>A	ENST00000389313.4	+	3	672	c.605G>A	c.(604-606)cGa>cAa	p.R202Q	SMTNL2_ENST00000338859.4_Missense_Mutation_p.R58Q	NM_001114974.1	NP_001108446.1	Q2TAL5	SMTL2_HUMAN	smoothelin-like 2	202										breast(1)|endometrium(9)|kidney(1)|lung(1)|skin(1)	13				READ - Rectum adenocarcinoma(115;0.0325)		GCCATCACCCGAGTCTCTGAC	0.637000													7	47					0	0	0.003080	0	0
NR0B1	190	broad.mit.edu	37	X	30322750	30322750	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:30322750G>A	ENST00000378970.4	-	2	1593	c.1359C>T	c.(1357-1359)atC>atT	p.I453I		NM_000475.4	NP_000466.2	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	453	Ligand-binding (By similarity).				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			central_nervous_system(2)|endometrium(2)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	24					Dexamethasone(DB01234)|Tretinoin(DB00755)	TGACTGTGCCGATGATGGGCC	0.458000													7	61					0	0	0.001984	0	0
TRAM1L1	133022	broad.mit.edu	37	4	118005585	118005585	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr4:118005585C>T	ENST00000310754.4	-	1	1151	c.965G>A	c.(964-966)aGg>aAg	p.R322K		NM_152402.2	NP_689615.2	Q8N609	TR1L1_HUMAN	translocation associated membrane protein 1-like 1	322	TLC.				protein transport|transmembrane transport	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22						TTCTACCCACCTCTGAAGCCA	0.413000													6	139					0	0	0.003080	0	0
PLXNA4	91584	broad.mit.edu	37	7	131866242	131866242	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:131866242G>A	ENST00000359827.3	-	18	4352	c.3390C>T	c.(3388-3390)atC>atT	p.I1130I	PLXNA4_ENST00000321063.4_Silent_p.I1130I			Q9HCM2	PLXA4_HUMAN	plexin A4	1130	IPT/TIG 3.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						TCTTGTTGAGGATGAGCAGGG	0.592000													6	129					0	0	0.003080	0	0
OR5A1	219982	broad.mit.edu	37	11	59211109	59211109	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr11:59211109C>T	ENST00000302030.2	+	1	493	c.468C>T	c.(466-468)ttC>ttT	p.F156F		NM_001004728.1	NP_001004728.1	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A, member 1	156					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	28						TTGGTGGCTTCCTGAGCTCCC	0.562000													10	266					0	0	0.010729	0	0
SLC4A3	6508	broad.mit.edu	37	2	220504246	220504246	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:220504246C>T	ENST00000358055.3	+	20	3578	c.3066C>T	c.(3064-3066)tcC>tcT	p.S1022S	SLC4A3_ENST00000273063.6_Silent_p.S1049S|SLC4A3_ENST00000373762.3_Silent_p.S1049S|SLC4A3_ENST00000317151.3_Silent_p.S1022S|SLC4A3_ENST00000373760.2_Silent_p.S1022S			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	1022	Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCAAGGGCTCCGGTTTCCACC	0.682000													6	80					0	0	0.003080	0	0
ALOXE3	59344	broad.mit.edu	37	17	8015436	8015436	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:8015436G>A	ENST00000380149.1	-	6	1257	c.1227C>T	c.(1225-1227)ttC>ttT	p.F409F	ALOXE3_ENST00000318227.3_Silent_p.F385F|ALOXE3_ENST00000448843.2_Silent_p.F253F			Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3	253	Lipoxygenase.				leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)	31						TATGGCACCAGAAGATGTTCT	0.532000													7	147					0	0	0.003080	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54936426	54936426	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr12:54936426G>A	ENST00000293373.6	+	31	3420	c.3341G>A	c.(3340-3342)cGa>cAa	p.R1114Q	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.R1064Q	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	1114					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity	p.R1114Q(1)		NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						GTCCTGCTTCGAAATGCCTAT	0.537000													9	117					0	0	0.008291	0	0
C7orf63	79846	broad.mit.edu	37	7	89938617	89938617	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:89938617G>A	ENST00000389297.4	+	22	2842	c.2591G>A	c.(2590-2592)aGa>aAa	p.R864K	C7orf63_ENST00000316089.8_Missense_Mutation_p.R818K|C7orf63_ENST00000497910.1_Missense_Mutation_p.R846K	NM_001039706.2|NM_001160138.1	NP_001034795.2|NP_001153610.1	A5D8W1	CG063_HUMAN	chromosome 7 open reading frame 63	864							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|prostate(3)	37						GAAGCCTCCAGATACCATAAA	0.308000													5	85					0	0	0.001168	0	0
CNTN6	27255	broad.mit.edu	37	3	1425027	1425027	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:1425027G>A	ENST00000446702.2	+	19	3079	c.2452G>A	c.(2452-2454)Gaa>Aaa	p.E818K	CNTN6_ENST00000539053.1_Missense_Mutation_p.E746K|CNTN6_ENST00000350110.2_Missense_Mutation_p.E818K			Q9UQ52	CNTN6_HUMAN	contactin 6	818	Fibronectin type-III 3.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane		p.E818Q(1)		breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		TTCTGCTTCTGAAATGGAGGT	0.423000													6	198					0	0	0.001168	0	0
GPR98	84059	broad.mit.edu	37	5	89920996	89920996	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr5:89920996G>A	ENST00000405460.2	+	6	704	c.608G>A	c.(607-609)gGa>gAa	p.G203E		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	203	Calx-beta 2.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CCAGTTAAAGGAAATATCACC	0.418000													4	17					0	0	0.000602	0	0
TAF1	6872	broad.mit.edu	37	X	70598118	70598118	+	Missense_Mutation	SNP	T	T	C			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:70598118T>C	ENST00000449580.1	+	7	1015	c.964T>C	c.(964-966)Tcc>Ccc	p.S322P	TAF1_ENST00000373790.4_Missense_Mutation_p.S322P|TAF1_ENST00000276072.3_Missense_Mutation_p.S343P|TAF1_ENST00000423759.1_Missense_Mutation_p.S343P			P21675	TAF1_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	322	Protein kinase 1.				G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			breast(13)|central_nervous_system(6)|cervix(1)|endometrium(25)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(16)|lung(34)|ovary(9)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	124	Renal(35;0.156)	all_lung(315;0.000321)				GTCCAAATTTTCCCAATCAAC	0.463000													3	27					0	0	0.004672	0	0
OGDHL	55753	broad.mit.edu	37	10	50955175	50955175	+	Missense_Mutation	SNP	G	G	A	rs148413282	byFrequency	TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr10:50955175G>A	ENST00000374103.4	-	9	1152	c.1067C>T	c.(1066-1068)tCg>tTg	p.S356L	OGDHL_ENST00000419399.1_Missense_Mutation_p.S299L|OGDHL_ENST00000432695.1_Missense_Mutation_p.S147L	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	356					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						GGCAACCAGCGACAGAGTGAT	0.592000													4	85					0	0	0.009096	0	0
C1QTNF2	114898	broad.mit.edu	37	5	159782013	159782013	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr5:159782013G>A	ENST00000393975.3	-	2	144	c.141C>T	c.(139-141)atC>atT	p.I47I		NM_031908.4	NP_114114.2	Q9BXJ5	C1QT2_HUMAN	C1q and tumor necrosis factor related protein 2	2	Collagen-like.					collagen				breast(2)|endometrium(2)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	13	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCACCCAGGGGATCATGGTGG	0.632000													4	21					0	0	0.009096	0	0
SCN10A	6336	broad.mit.edu	37	3	38743472	38743472	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:38743472C>T	ENST00000449082.2	-	26	4514	c.4515G>A	c.(4513-4515)acG>acA	p.T1505T		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1505					sensory perception	voltage-gated sodium channel complex		p.T1505T(1)		NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CCAGAATTTTCGTCTTTTCTT	0.453000													5	66					0	0	0.001168	0	0
SLC13A1	6561	broad.mit.edu	37	7	122765666	122765666	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:122765666G>A	ENST00000194130.2	-	11	1236	c.1197C>T	c.(1195-1197)atC>atT	p.I399I	SLC13A1_ENST00000539873.1_3'UTR	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	399						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	TCTTAGCTGGGATAAGAAAGA	0.328000													4	146					0	0	0.001168	0	0
DST	667	broad.mit.edu	37	6	56765251	56765251	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:56765251G>A	ENST00000370754.5	-	3	384	c.385C>T	c.(385-387)Cac>Tac	p.H129Y				Q03001	DYST_HUMAN	dystonin	0	Actin-binding.|CH 1.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGAACAGAGTGATAAAATTCT	0.408000													11	201					0	0	0.010729	0	0
KCNK9	51305	broad.mit.edu	37	8	140630564	140630564	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr8:140630564G>A	ENST00000520439.1	-	2	1125	c.1062C>T	c.(1060-1062)atC>atT	p.I354I	KCNK9_ENST00000303015.1_Silent_p.I354I			Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	354						integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(9)|kidney(1)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)	43	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			ACCCAGGAGAGATGGAGCTAA	0.502000													5	112					0	0	0.001168	0	0
CFB	629	broad.mit.edu	37	6	31911205	31911205	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:31911205G>A	ENST00000456570.1	+	9	1064	c.1009G>A	c.(1009-1011)Gag>Aag	p.E337K	C2_ENST00000469372.1_Missense_Mutation_p.E244K|CFB_ENST00000477310.1_Missense_Mutation_p.E261K|C2_ENST00000299367.5_Missense_Mutation_p.E490K|CFB_ENST00000556679.1_Missense_Mutation_p.E337K|C2_ENST00000452323.2_Missense_Mutation_p.E276K|C2_ENST00000442278.2_Missense_Mutation_p.E358K			P00751	CFAB_HUMAN	complement factor B	509	VWFA.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						CAAGAGCCAAGAGACCTGCCG	0.592000													7	397					0	0	0.004482	0	0
PPP1R1B	84152	broad.mit.edu	37	17	37785468	37785468	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:37785468G>A	ENST00000254079.4	+	2	596	c.127G>A	c.(127-129)Gag>Aag	p.E43K	PPP1R1B_ENST00000580825.1_Missense_Mutation_p.E43K|PPP1R1B_ENST00000579000.1_Missense_Mutation_p.E43K|PPP1R1B_ENST00000394267.2_Missense_Mutation_p.E7K|PPP1R1B_ENST00000394265.1_Missense_Mutation_p.E7K	NM_032192.3	NP_115568.2	Q9UD71	PPR1B_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 1B	43					signal transduction	cytosol	protein kinase inhibitor activity|protein phosphatase inhibitor activity			kidney(1)|large_intestine(1)|liver(1)|lung(2)	5	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CCGGCTCTCAGAGCACTCCTC	0.647000													6	70					0	0	0.006214	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144867988	144867988	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:144867988C>T	ENST00000369359.4	-	36	5897	c.5859G>A	c.(5857-5859)caG>caA	p.Q1953Q	PDE4DIP_ENST00000530740.1_Silent_p.Q1902Q|PDE4DIP_ENST00000369356.4_Silent_p.Q1817Q|PDE4DIP_ENST00000313382.9_Silent_p.Q1711Q|PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000369354.3_Silent_p.Q1817Q			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1817					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CACTCCCTTTCTGAGGCCTCA	0.547000			T	PDGFRB	MPD								10	380					0	0	0.006214	0	0
CDK19	23097	broad.mit.edu	37	6	110942465	110942465	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:110942465C>T	ENST00000368911.3	-	12	1398	c.1219G>A	c.(1219-1221)Ggg>Agg	p.G407R	CDK19_ENST00000323817.3_Missense_Mutation_p.G347R|CDK19_ENST00000413605.2_Missense_Mutation_p.G283R	NM_015076.3	NP_055891.1	Q9BWU1	CDK19_HUMAN	cyclin-dependent kinase 19	407							ATP binding|cyclin-dependent protein kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)	22						CCTGCGGTCCCGTTGGTCTGG	0.682000													8	94					0	0	0.003080	0	0
RELN	5649	broad.mit.edu	37	7	103163959	103163959	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:103163959G>A	ENST00000428762.1	-	47	7528	c.7369C>T	c.(7369-7371)Cgt>Tgt	p.R2457C	RELN_ENST00000343529.5_Missense_Mutation_p.R2457C|RELN_ENST00000424685.2_Missense_Mutation_p.R2457C	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	2457					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TGATGCCAACGGAAACGAGTG	0.453000													4	66					0	0	0.000602	0	0
GRIN2B	2904	broad.mit.edu	37	12	13716761	13716761	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr12:13716761G>A	ENST00000279593.3	-	13	3620	c.3411C>T	c.(3409-3411)ttC>ttT	p.F1137F		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	1137					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding	p.F1137L(1)		NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCTTTGTTCGGAACTGGTCCA	0.602000													8	48					0	0	0.004482	0	0
NPAP1	23742	broad.mit.edu	37	15	24924106	24924106	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:24924106C>T	ENST00000329468.2	+	1	3566	c.3092C>T	c.(3091-3093)tCc>tTc	p.S1031F		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		GGCCCCAGTTCCACATCAGGA	0.547000													5	44					0	0	0.000602	0	0
OR8U1	219417	broad.mit.edu	37	11	56143558	56143558	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr11:56143558C>T	ENST00000302270.1	+	1	459	c.459C>T	c.(457-459)ttC>ttT	p.F153F		NM_001005204.1	NP_001005204.1			olfactory receptor, family 8, subfamily U, member 1											NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(23)|ovary(4)|skin(1)|stomach(1)	39	Esophageal squamous(21;0.00448)					GCTATAGCTTCCTAATGGCAC	0.438000													7	114					0	0	0.003080	0	0
ITGA6	3655	broad.mit.edu	37	2	173337518	173337518	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:173337518C>T	ENST00000375221.2	+	6	995	c.792C>T	c.(790-792)acC>acT	p.T264T	ITGA6_ENST00000409532.1_Silent_p.T106T|ITGA6_ENST00000343713.4_Silent_p.T220T|ITGA6_ENST00000264107.7_Intron|ITGA6_ENST00000264106.6_Silent_p.T264T|ITGA6_ENST00000409080.1_Intron			P23229	ITA6_HUMAN	integrin, alpha 6	264					blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	44			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			TGTTTTTGACCAGCGTTTCCT	0.478000													4	106					0	0	0.009096	0	0
SUN5	140732	broad.mit.edu	37	20	31583443	31583443	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr20:31583443C>T	ENST00000356173.3	-	8	608	c.516G>A	c.(514-516)atG>atA	p.M172I	SUN5_ENST00000375523.3_Missense_Mutation_p.M147I	NM_080675.3	NP_542406.2	Q8TC36	SUN5_HUMAN	Sad1 and UNC84 domain containing 5	172					spermatogenesis					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	25						ACATGGCTTCCATCTCCTGGA	0.493000													7	214					0	0	0.003080	0	0
ESYT3	83850	broad.mit.edu	37	3	138187005	138187005	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:138187005C>T	ENST00000389567.4	+	12	1463	c.1277C>T	c.(1276-1278)tCa>tTa	p.S426L		NM_031913.3	NP_114119.2	A0FGR9	ESYT3_HUMAN	extended synaptotagmin-like protein 3	426						integral to membrane|plasma membrane				breast(1)|endometrium(5)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	25						GAGTGGCTTTCATTGCTTACT	0.582000													26	518					0	0	0.007291	0	0
ATP6AP2	10159	broad.mit.edu	37	X	40450601	40450601	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:40450601C>T	ENST00000378438.4	+	3	442	c.284C>T	c.(283-285)tCg>tTg	p.S95L	ATP6AP2_ENST00000535777.1_Missense_Mutation_p.S95L|ATP6AP2_ENST00000486558.1_3'UTR|ATP6AP2_ENST00000544975.1_Missense_Mutation_p.S19L|ATP6AP2_ENST00000535539.1_Missense_Mutation_p.S95L	NM_005765.2	NP_005756.2	O75787	RENR_HUMAN	ATPase, H+ transporting, lysosomal accessory protein 2	95					angiotensin maturation|positive regulation of transforming growth factor-beta1 production|regulation of MAPKKK cascade	external side of plasma membrane|integral to membrane	protein binding|receptor activity			endometrium(1)|large_intestine(1)|lung(2)	4						AGTGTCATTTCGTACCCTTTG	0.428000													5	23					0	0	0.000602	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70712585	70712585	+	RNA	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:70712585C>T	ENST00000530196.1	-	0	1933					NR_003951.1																						TATGTGCATCCTTAAATGATA	0.438000													6	64					0	0	0.001168	0	0
TULP2	7288	broad.mit.edu	37	19	49388786	49388786	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:49388786C>T	ENST00000221399.3	-	9	1124	c.980G>A	c.(979-981)aGg>aAg	p.R327K		NM_003323.2	NP_003314.2	O00295	TULP2_HUMAN	tubby like protein 2	327					visual perception	cytoplasm|extracellular region				NS(1)|breast(2)|central_nervous_system(2)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	22		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		AGTTTTGCTCCTTCTTCTCTT	0.512000													7	57					0	0	0.001984	0	0
XKR3	150165	broad.mit.edu	37	22	17288877	17288877	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr22:17288877G>A	ENST00000331428.5	-	2	189	c.87C>T	c.(85-87)ctC>ctT	p.L29L		NM_175878.3	NP_787074.2	Q5GH77	XKR3_HUMAN	XK, Kell blood group complex subunit-related family, member 3	29						integral to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(6)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AGCTTAGATGGAGTCTCTGGC	0.408000													5	76					0	0	0.000602	0	0
UGT1A3	54659	broad.mit.edu	37	2	234638020	234638020	+	Missense_Mutation	SNP	C	C	T	rs143192251		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:234638020C>T	ENST00000482026.1	+	1	267	c.248C>T	c.(247-249)tCg>tTg	p.S83L	UGT1A6_ENST00000406651.1_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A4_ENST00000373409.3_Intron	NM_019093.2	NP_061966.1														breast(2)|endometrium(7)|kidney(18)|large_intestine(6)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	46		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		TATGCCATTTCGTGGACCCAG	0.468000													7	84					0	0	0.006214	0	0
P4HB	5034	broad.mit.edu	37	17	79804386	79804386	+	Silent	SNP	G	G	C			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:79804386G>C	ENST00000331483.4	-	7	1197	c.975C>G	c.(973-975)acC>acG	p.T325T	P4HB_ENST00000472244.1_5'UTR|P4HB_ENST00000439918.2_Silent_p.T281T|P4HB_ENST00000576390.1_Intron	NM_000918.3	NP_000909.2	P07237	PDIA1_HUMAN	prolyl 4-hydroxylase, beta polypeptide	325					cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	cell surface|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			NS(1)|breast(1)|large_intestine(2)|lung(17)|urinary_tract(1)	22	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)			GCTTGTACTTGGTCATCTCCT	0.612000													5	87					0	0	0.000602	0	0
TNR	7143	broad.mit.edu	37	1	175365770	175365770	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:175365770C>T	ENST00000367674.1	-	5	1858	c.1150G>A	c.(1150-1152)Gag>Aag	p.E384K	TNR_ENST00000263525.2_Missense_Mutation_p.E384K	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	384	Fibronectin type-III 1.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					GGCTCCAGCTCCGTGATGGTG	0.597000													4	46					0	0	0.009096	0	0
ZNF285	26974	broad.mit.edu	37	19	44901422	44901422	+	Splice_Site	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:44901422C>T	ENST00000330997.4	-	2	22		c.e2-1		CTC-512J12.4_ENST00000588655.1_RNA|CTC-512J12.6_ENST00000588212.1_Splice_Site|ZNF285_ENST00000591679.1_Splice_Site|ZNF285_ENST00000544719.2_Splice_Site	NM_152354.3	NP_689567.3			zinc finger protein 285											breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|prostate(5)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	44						AAAAGCAGAACTGCAAAGAAG	0.378000													4	70					0	0	0.009096	0	0
OR2G2	81470	broad.mit.edu	37	1	247752384	247752384	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:247752384C>T	ENST00000320065.1	+	1	723	c.723C>T	c.(721-723)ttC>ttT	p.F241F	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	241					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			AGAAAGCATTCGGGACCTGCT	0.502000													4	72					0	0	0.009096	0	0
RINT1	60561	broad.mit.edu	37	7	105183011	105183011	+	Missense_Mutation	SNP	G	G	A	rs139214585	by1000genomes	TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:105183011G>A	ENST00000257700.2	+	4	661	c.430G>A	c.(430-432)Gat>Aat	p.D144N		NM_021930.4	NP_068749.3	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	144					cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						TTGGATGGACGATCTTGGAAC	0.413000													5	76					0	0	0.001984	0	0
PAK3	5063	broad.mit.edu	37	X	110385365	110385365	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:110385365C>T	ENST00000519681.1	+	6	659	c.217C>T	c.(217-219)Cct>Tct	p.P73S	PAK3_ENST00000372007.4_Missense_Mutation_p.P73S|PAK3_ENST00000446737.1_Missense_Mutation_p.P73S|PAK3_ENST00000425146.1_Missense_Mutation_p.P73S|PAK3_ENST00000518291.1_Missense_Mutation_p.P73S|PAK3_ENST00000372010.1_Missense_Mutation_p.P73S|PAK3_ENST00000262836.4_Missense_Mutation_p.P73S|PAK3_ENST00000360648.4_Missense_Mutation_p.P73S|PAK3_ENST00000417227.1_Missense_Mutation_p.P73S			O75914	PAK3_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 3	73	Autoregulatory region (By similarity).|CRIB.|GTPase-binding (By similarity).			P -> S (in Ref. 2).	multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(15)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	41						GATCTCTCTTCCTTCAGACTT	0.413000										TSP Lung(19;0.15)			6	104					0	0	0.001984	0	0
HECW1	23072	broad.mit.edu	37	7	43436449	43436449	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:43436449G>A	ENST00000395891.1	+	7	1197	c.592G>A	c.(592-594)Gga>Aga	p.G198R	HECW1_ENST00000471043.1_3'UTR|HECW1_ENST00000453890.1_Missense_Mutation_p.G198R	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	198	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						GACCGTCCAAGGACAAGGAAG	0.418000													6	70					0	0	0.001168	0	0
GCNT3	9245	broad.mit.edu	37	15	59911184	59911184	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:59911184G>A	ENST00000396065.1	+	3	1195	c.747G>A	c.(745-747)agG>agA	p.R249R	GCNT3_ENST00000560585.1_Silent_p.R249R	NM_004751.2	NP_004742.1	O95395	GCNT3_HUMAN	glucosaminyl (N-acetyl) transferase 3, mucin type	249					protein O-linked glycosylation	Golgi membrane|integral to membrane|membrane fraction	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TGAATGGGAGGAATAGCATGG	0.458000													7	146					0	0	0.003080	0	0
DGKZ	8525	broad.mit.edu	37	11	46395974	46395974	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr11:46395974C>T	ENST00000454345.1	+	17	2120	c.1995C>T	c.(1993-1995)agC>agT	p.S665S	DGKZ_ENST00000318201.8_Silent_p.S454S|DGKZ_ENST00000421244.2_Silent_p.S477S|DGKZ_ENST00000532868.2_Silent_p.S481S|DGKZ_ENST00000343674.6_Silent_p.S493S|DGKZ_ENST00000456247.2_Silent_p.S476S|DGKZ_ENST00000527911.1_Silent_p.S477S|DGKZ_ENST00000395574.3_Silent_p.S443S|DGKZ_ENST00000528615.1_Silent_p.S255S|DGKZ_ENST00000543978.1_Intron	NM_001105540.1	NP_001099010.1	Q13574	DGKZ_HUMAN	diacylglycerol kinase, zeta	665					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|pancreas(1)|prostate(1)|skin(1)	25				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		AATTCAACAGCCGCTTTCGGA	0.642000													4	70					0	0	0.009096	0	0
DOCK1	1793	broad.mit.edu	37	10	129224221	129224221	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr10:129224221C>T	ENST00000280333.6	+	47	4906	c.4797C>T	c.(4795-4797)gcC>gcT	p.A1599A		NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1599	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		GGATGGAGGCCTGTTTCAAAC	0.517000													10	218					0	0	0.006214	0	0
HAO2	51179	broad.mit.edu	37	1	119936434	119936434	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:119936434C>T	ENST00000361035.4	+	9	1349	c.1066C>T	c.(1066-1068)Cga>Tga	p.R356*	HAO2_ENST00000325945.3_Nonsense_Mutation_p.R343*|HAO2_ENST00000482991.1_3'UTR	NM_001005783.1	NP_001005783.1	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2 (long chain)	343					fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		TGAGATCAATCGAAACTTGGT	0.478000													5	125					0	0	0.000602	0	0
TTC17	55761	broad.mit.edu	37	11	43511823	43511823	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr11:43511823C>T	ENST00000039989.4	+	22	3079	c.3065C>T	c.(3064-3066)gCc>gTc	p.A1022V		NM_018259.5	NP_060729.2	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	1022							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(27)|ovary(5)|prostate(3)|skin(3)	53						AGCATGGCAGCCCTCTACTGG	0.522000													6	80					0	0	0.001984	0	0
ABLIM1	3983	broad.mit.edu	37	10	116335274	116335274	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr10:116335274C>T	ENST00000369252.4	-	3	585	c.284G>A	c.(283-285)gGg>gAg	p.G95E	ABLIM1_ENST00000277895.5_Missense_Mutation_p.G155E|ABLIM1_ENST00000533213.2_Missense_Mutation_p.G95E	NM_001003407.1|NM_001003408.1	NP_001003407.1|NP_001003408.1	O14639	ABLM1_HUMAN	actin binding LIM protein 1	155					axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	30		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		GCAGCGTGTCCCGTACATCCG	0.547000													4	86					0	0	0.009096	0	0
INVS	27130	broad.mit.edu	37	9	103035155	103035155	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr9:103035155C>T	ENST00000262457.2	+	12	1766	c.1581C>T	c.(1579-1581)ccC>ccT	p.P527P	INVS_ENST00000262456.2_Silent_p.P527P|INVS_ENST00000541287.1_Silent_p.P431P	NM_014425.3	NP_055240.2	Q9Y283	INVS_HUMAN	inversin	527					negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|membrane|microtubule|nucleus|spindle	calmodulin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31		Acute lymphoblastic leukemia(62;0.056)				GATACACACCCCTTGATTATG	0.418000													4	141					0	0	0.001168	0	0
TRBV6-9	28598	broad.mit.edu	37	7	142104302	142104302	+	RNA	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:142104302G>A	ENST00000390379.1	-	0	162																											GGGTCTTGTCGATACCAGGAC	0.507000													6	120					0	0	0.001168	0	0
FURIN	5045	broad.mit.edu	37	15	91424025	91424025	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:91424025C>T	ENST00000268171.3	+	14	1940	c.1661C>T	c.(1660-1662)aCc>aTc	p.T554I		NM_002569.2	NP_002560.1	P09958	FURIN_HUMAN	furin (paired basic amino acid cleaving enzyme)	554					cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(4)|endometrium(4)|large_intestine(3)|liver(2)|lung(13)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	36	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			ATTGAAAACACCAGCGAAGCC	0.562000													13	299					0	0	0.001855	0	0
TRPM2	7226	broad.mit.edu	37	21	45825905	45825905	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr21:45825905C>T	ENST00000397928.1	+	18	3220	c.2775C>T	c.(2773-2775)atC>atT	p.I925I	TRPM2_ENST00000397932.2_Silent_p.I925I|TRPM2_ENST00000300482.5_Silent_p.I925I|TRPM2_ENST00000300481.9_Silent_p.I905I|TRPM2_ENST00000498430.1_3'UTR	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	925						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						CCAAGATCATCATTGTGAAGC	0.642000													9	175					0	0	0.006214	0	0
HMHA1	23526	broad.mit.edu	37	19	1079932	1079932	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:1079932G>A	ENST00000313093.2	+	13	1749	c.1518G>A	c.(1516-1518)acG>acA	p.T506T	HMHA1_ENST00000536472.1_Silent_p.T346T|HMHA1_ENST00000543365.1_Silent_p.T389T|HMHA1_ENST00000590577.1_Silent_p.T141T|HMHA1_ENST00000539243.2_Silent_p.T522T|HMHA1_ENST00000590214.1_Silent_p.T533T|HMHA1_ENST00000586866.1_Silent_p.T510T	NM_012292.3	NP_036424.2	Q92619	HMHA1_HUMAN	histocompatibility (minor) HA-1	506					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(7)|ovary(1)|prostate(2)	16		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCAGGCCACGATCTCCTACT	0.677000													8	115					0	0	0.008291	0	0
MUC17	140453	broad.mit.edu	37	7	100681341	100681341	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:100681341C>T	ENST00000306151.4	+	3	6708	c.6644C>T	c.(6643-6645)cCt>cTt	p.P2215L		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2215	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					ACCTCAACTCCTAGTGAAGGA	0.502000													20	373					0	0	0.012319	0	0
USP2	9099	broad.mit.edu	37	11	119243689	119243689	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr11:119243689G>A	ENST00000260187.2	-	2	796	c.502C>T	c.(502-504)Cgc>Tgc	p.R168C	RP11-334E6.3_ENST00000530918.2_RNA|USP2_ENST00000455332.2_Intron	NM_004205.4	NP_004196.4	O75604	UBP2_HUMAN	ubiquitin specific peptidase 2	168	Necessary for interaction with MDM4.				cell cycle|muscle organ development|negative regulation of transcription from RNA polymerase II promoter|positive regulation of mitotic cell cycle|protein deubiquitination|protein stabilization|ubiquitin-dependent protein catabolic process	nucleus|perinuclear region of cytoplasm	cyclin binding|cysteine-type endopeptidase activity|metal ion binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	24		all_hematologic(192;4.65e-05)|Breast(348;0.0101)|all_neural(223;0.0218)|Medulloblastoma(222;0.0425)|Renal(330;0.157)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.000513)|Colorectal(284;0.0116)|Lung(307;0.0853)|LUSC - Lung squamous cell carcinoma(976;0.0889)		ATGGGGCTGCGGCCCAGGTTC	0.632000													5	98					0	0	0.001168	0	0
ZNF616	90317	broad.mit.edu	37	19	52619219	52619219	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:52619219G>A	ENST00000600228.1	-	4	1459	c.1198C>T	c.(1198-1200)Cga>Tga	p.R400*	ZNF616_ENST00000330123.5_3'UTR	NM_178523.3	NP_848618.2	Q08AN1	ZN616_HUMAN	zinc finger protein 616	400					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		TGAATTCGTCGATGCACTGCA	0.418000													9	117					0	0	0.004482	0	0
ZGPAT	84619	broad.mit.edu	37	20	62366045	62366045	+	Missense_Mutation	SNP	C	C	T	rs142220817	by1000genomes	TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr20:62366045C>T	ENST00000328969.5	+	5	1047	c.920C>T	c.(919-921)cCg>cTg	p.P307L	ZGPAT_ENST00000355969.6_Intron|ZGPAT_ENST00000357119.4_Intron|ZGPAT_ENST00000369967.3_Intron|ZGPAT_ENST00000490623.1_Intron|ZGPAT_ENST00000448100.1_Intron	NM_032527.4	NP_115916.3	Q8N5A5	ZGPAT_HUMAN	zinc finger, CCCH-type with G patch domain	307					negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)	14	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					GCCCTCTGTCCGTCTCTTGCA	0.627000													5	165					0	0	0.000602	0	0
TRAV8-7	28679	broad.mit.edu	37	14	22600915	22600915	+	RNA	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:22600915G>A	ENST00000390456.3	+	0	260																											TTTAAGAAGAGCGAAACCTCC	0.507000													3	33					0	0	0.004672	0	0
PRSS37	136242	broad.mit.edu	37	7	141537835	141537835	+	Silent	SNP	G	G	A	rs149011966		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:141537835G>A	ENST00000350549.3	-	3	626	c.255C>T	c.(253-255)atC>atT	p.I85I	PRSS37_ENST00000438520.1_Silent_p.I85I	NM_001008270.2|NM_001171951.1	NP_001008271.2|NP_001165422.1	A4D1T9	PRS37_HUMAN	protease, serine, 37	85	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity	p.I85I(1)		central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|skin(3)	15						AGTAGCGGACGATCTGAATGG	0.507000													11	165					0	0	0.002450	0	0
SH3TC2	79628	broad.mit.edu	37	5	148422290	148422290	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr5:148422290C>T	ENST00000515425.1	-	5	597	c.496G>A	c.(496-498)Gaa>Aaa	p.E166K	SH3TC2_ENST00000512049.1_Missense_Mutation_p.E159K|SH3TC2_ENST00000394358.2_Missense_Mutation_p.E51K	NM_024577.3	NP_078853.2	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	166							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TATATTGTTTCCAGGTGTTTA	0.438000													5	67					0	0	0.001168	0	0
SERPINB13	5275	broad.mit.edu	37	18	61262319	61262319	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr18:61262319C>T	ENST00000344731.5	+	7	774	c.672C>T	c.(670-672)ttC>ttT	p.F224F	SERPINB13_ENST00000269489.5_Intron	NM_012397.3	NP_036529.1	Q9UIV8	SPB13_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 13	224					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						GCTTCACTTTCCTGGAGGACT	0.433000													4	60					0	0	0.001168	0	0
IGHM	3507	broad.mit.edu	37	14	106321285	106321285	+	RNA	SNP	A	A	C			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:106321285A>C	ENST00000390559.2	-	0	703																											CTTGGTGAGGAAGATGCTGGC	0.572000													8	181					0	0	0.004482	0	0
STK31	56164	broad.mit.edu	37	7	23793998	23793998	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:23793998G>A	ENST00000354639.3	+	10	1593	c.1129G>A	c.(1129-1131)Ggg>Agg	p.G377R	STK31_ENST00000355870.3_Missense_Mutation_p.G400R|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000428484.1_Missense_Mutation_p.G377R|STK31_ENST00000433467.2_Missense_Mutation_p.G400R	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	400							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						GTTGGATGAAGGGTGCTTTAC	0.373000													6	83					0	0	0.001984	0	0
SHROOM2	357	broad.mit.edu	37	X	9900855	9900855	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:9900855C>T	ENST00000380913.3	+	6	3622	c.3532C>T	c.(3532-3534)Ccc>Tcc	p.P1178S	SHROOM2_ENST00000493668.1_3'UTR|SHROOM2_ENST00000418909.2_Missense_Mutation_p.P13S	NM_001649.2	NP_001640.1	Q13796	SHRM2_HUMAN	shroom family member 2	1178					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			breast(4)|central_nervous_system(2)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	57		Hepatocellular(5;0.000888)				CCAGTTCGCCCCCCAGAAACT	0.627000													3	20					0	0	0.004672	0	0
ZNF326	284695	broad.mit.edu	37	1	90473073	90473073	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:90473073C>T	ENST00000340281.4	+	5	522	c.379C>T	c.(379-381)Cag>Tag	p.Q127*	ZNF326_ENST00000455342.2_Intron|ZNF326_ENST00000370447.2_Intron	NM_182976.2	NP_892021.1	Q5BKZ1	ZN326_HUMAN	zinc finger protein 326	127	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	DNA binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(7)|ovary(1)	25		all_lung(203;0.0116)|Lung NSC(277;0.0417)		all cancers(265;0.00728)|Epithelial(280;0.0265)		AGGTAGAAACCAGGGCGGGTC	0.493000													5	164					0	0	0.001168	0	0
TNS4	84951	broad.mit.edu	37	17	38643407	38643407	+	Missense_Mutation	SNP	C	C	T	rs150836111	byFrequency	TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:38643407C>T	ENST00000254051.6	-	4	1327	c.1169G>A	c.(1168-1170)cGg>cAg	p.R390Q		NM_032865.5	NP_116254.4	Q8IZW8	TENS4_HUMAN	tensin 4	390					apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	30		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			TCCTGGGGTCCGCTGGGGTGG	0.617000													8	203					0	0	0.003080	0	0
HSPA1L	3305	broad.mit.edu	37	6	31778018	31778018	+	Missense_Mutation	SNP	C	C	T	rs139052456		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:31778018C>T	ENST00000375654.4	-	2	1921	c.1732G>A	c.(1732-1734)Gag>Aag	p.E578K	HSPA1L_ENST00000417199.3_Missense_Mutation_p.E578K	NM_005527.3	NP_005518.3	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	578					response to unfolded protein		ATP binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						GAAAGGAGCTCGTTGCATTTA	0.383000													23	713					0	0	0.002780	0	0
SLC6A16	28968	broad.mit.edu	37	19	49797112	49797112	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:49797112G>A	ENST00000454748.3	-	9	1791	c.1590C>T	c.(1588-1590)ttC>ttT	p.F530F	SLC6A16_ENST00000335875.4_Silent_p.F530F			Q9GZN6	S6A16_HUMAN	solute carrier family 6, member 16	530						integral to membrane|intracellular	neurotransmitter:sodium symporter activity			NS(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00099)|GBM - Glioblastoma multiforme(486;0.0336)		GTTTCCTGAAGAAAGAGAAGG	0.498000													10	197					0	0	0.010729	0	0
ADAM12	8038	broad.mit.edu	37	10	127760074	127760074	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr10:127760074C>T	ENST00000368679.4	-	12	1613	c.1304G>A	c.(1303-1305)gGa>gAa	p.G435E	ADAM12_ENST00000368676.4_Missense_Mutation_p.G435E	NM_003474.4	NP_003465.3	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12	435	Disintegrin.				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			biliary_tract(1)|breast(7)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		ACACTCCTCTCCTTCTTCCAC	0.522000													10	121					0	0	0.010729	0	0
TUSC3	7991	broad.mit.edu	37	8	15519760	15519760	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr8:15519760C>T	ENST00000382020.4	+	5	871	c.663C>T	c.(661-663)aaC>aaT	p.N221N	TUSC3_ENST00000503731.1_Silent_p.N221N|TUSC3_ENST00000506802.1_Silent_p.N221N|TUSC3_ENST00000503191.1_3'UTR|TUSC3_ENST00000509380.1_Silent_p.N221N	NM_178234.2	NP_839952.1	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3	221					cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(10)|ovary(2)	28				Colorectal(111;0.113)		GAAGGAACAACTTGGAGTTCA	0.403000													6	111					0	0	0.001984	0	0
HELZ	9931	broad.mit.edu	37	17	65124948	65124948	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:65124948G>A	ENST00000358691.5	-	24	3372	c.3206C>T	c.(3205-3207)gCc>gTc	p.A1069V	HELZ_ENST00000580168.1_Missense_Mutation_p.A1070V	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					ATGACACAGGGCAATAAACCG	0.343000													4	101					0	0	0.000602	0	0
EGFL6	25975	broad.mit.edu	37	X	13624618	13624618	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:13624618G>A	ENST00000361306.1	+	6	898	c.641G>A	c.(640-642)cGa>cAa	p.R214Q	EGFL6_ENST00000380602.3_Missense_Mutation_p.R214Q	NM_001167890.1|NM_015507.3	NP_001161362.1|NP_056322.2	Q8IUX8	EGFL6_HUMAN	EGF-like-domain, multiple 6	214					cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(7)|prostate(1)|skin(3)	23						ATCAGTGGACGATATGACTGT	0.403000													6	55					0	0	0.001984	0	0
SUPT5H	6829	broad.mit.edu	37	19	39964610	39964610	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:39964610G>A	ENST00000599117.1	+	27	2867	c.2500G>A	c.(2500-2502)Gaa>Aaa	p.E834K	SUPT5H_ENST00000598725.1_Missense_Mutation_p.E834K|SUPT5H_ENST00000359191.6_Missense_Mutation_p.E830K|SUPT5H_ENST00000402194.2_Missense_Mutation_p.E830K|SUPT5H_ENST00000432763.2_Missense_Mutation_p.E834K			O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog (S. cerevisiae)	834					cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(13)|lung(12)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	51	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CAGGGCTGAGGAAGAATATGA	0.562000											OREG0025462	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	101					0	0	0.001984	0	0
HOXB1	3211	broad.mit.edu	37	17	46607131	46607131	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:46607131C>T	ENST00000239174.6	-	2	776	c.684G>A	c.(682-684)ctG>ctA	p.L228L	HOXB1_ENST00000577092.1_3'UTR	NM_002144.3	NP_002135.2	P14653	HXB1_HUMAN	homeobox B1	228						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						GGGCCCGGCTCAGGTACTTGT	0.572000													8	200					0	0	0.003080	0	0
TTN	7273	broad.mit.edu	37	2	179616599	179616599	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:179616599G>A	ENST00000360870.5	-	46	10750	c.10528C>T	c.(10528-10530)Ctt>Ttt	p.L3510F	TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342992.6_Intron|TTN_ENST00000460472.2_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	3509	Ig-like 21.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTAAATGTAAGTTTCTGGGTA	0.373000													6	116					0	0	0.001168	0	0
SRPK3	26576	broad.mit.edu	37	X	153050922	153050922	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:153050922G>A	ENST00000489426.1	+	21	4218	c.1852G>A	c.(1852-1854)Gaa>Aaa	p.E618K	SRPK3_ENST00000370108.3_Missense_Mutation_p.E518K|SRPK3_ENST00000370104.1_Missense_Mutation_p.E550K|SRPK3_ENST00000393786.3_Missense_Mutation_p.E517K|SRPK3_ENST00000370101.3_Missense_Mutation_p.E551K|SRPK3_ENST00000370100.1_Missense_Mutation_p.E476K			Q9UPE1	SRPK3_HUMAN	SRSF protein kinase 3	551					cell differentiation|muscle organ development|muscle tissue development		ATP binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(2)|lung(4)|ovary(2)|pancreas(2)|urinary_tract(1)	13	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					GTACATCCCCGAAAAGCGGGC	0.617000													4	58					0	0	0.009096	0	0
OR10K2	391107	broad.mit.edu	37	1	158389802	158389802	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:158389802G>A	ENST00000314902.2	-	1	854	c.855C>T	c.(853-855)ttC>ttT	p.F285F		NM_001004476.1	NP_001004476.1	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K, member 2	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(19)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_hematologic(112;0.0378)					TCATTGGGTTGAACAATGGAG	0.358000													6	66					0	0	0.001984	0	0
TSSK3	81629	broad.mit.edu	37	1	32829396	32829396	+	Missense_Mutation	SNP	C	C	T	rs138699524		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:32829396C>T	ENST00000373534.3	+	2	851	c.346C>T	c.(346-348)Cgt>Tgt	p.R116C	FAM229A_ENST00000415596.1_Intron	NM_052841.3	NP_443073.1	Q96PN8	TSSK3_HUMAN	testis-specific serine kinase 3	116	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|large_intestine(6)|lung(5)|skin(2)|stomach(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.17)|Breast(348;0.212)				GGCCCTCTTCCGTCAGATGGT	0.597000													7	95					0	0	0.001984	0	0
DIDO1	11083	broad.mit.edu	37	20	61537302	61537302	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr20:61537302G>A	ENST00000266070.4	-	6	1850	c.1525C>T	c.(1525-1527)Cac>Tac	p.H509Y	DIDO1_ENST00000395343.1_Missense_Mutation_p.H509Y|DIDO1_ENST00000370368.1_Missense_Mutation_p.H509Y|DIDO1_ENST00000370371.4_Missense_Mutation_p.H509Y|DIDO1_ENST00000370366.1_Missense_Mutation_p.H509Y|DIDO1_ENST00000354665.4_Missense_Mutation_p.H509Y|DIDO1_ENST00000266071.5_Missense_Mutation_p.H509Y|DIDO1_ENST00000395335.2_Missense_Mutation_p.H509Y|DIDO1_ENST00000395340.1_Missense_Mutation_p.H509Y	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	509					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					TTGTAATTGTGATCGCTCGCC	0.557000													6	159					0	0	0.001168	0	0
TAS2R38	5726	broad.mit.edu	37	7	141673373	141673373	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:141673373C>T	ENST00000547270.1	-	1	200	c.117G>A	c.(115-117)gtG>gtA	p.V39V		NM_176817.4	NP_789787.4	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	39					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			NS(2)|breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)|skin(1)|stomach(1)	21	Melanoma(164;0.0171)					CCCAAAAATTCACCAAGAAAA	0.493000													6	76					0	0	0.001168	0	0
FLG	2312	broad.mit.edu	37	1	152280468	152280468	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:152280468G>A	ENST00000368799.1	-	3	6929	c.6894C>T	c.(6892-6894)agC>agT	p.S2298S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2298	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATTGTCTGGAGCTCTCTGCAG	0.542000									Ichthyosis				7	351					0	0	0.003080	0	0
HNF4G	3174	broad.mit.edu	37	8	76465357	76465357	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr8:76465357G>A	ENST00000396423.2	+	5	664	c.540G>A	c.(538-540)atG>atA	p.M180I	HNF4G_ENST00000354370.1_Missense_Mutation_p.M143I	NM_004133.4	NP_004124.4	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	143					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	37	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			GTGAATCTATGAAACAGCAGC	0.368000													4	60					0	0	0.009096	0	0
ALDH3A1	218	broad.mit.edu	37	17	19646769	19646769	+	Missense_Mutation	SNP	C	C	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:19646769C>A	ENST00000457500.2	-	2	499	c.170G>T	c.(169-171)tGg>tTg	p.W57L	ALDH3A1_ENST00000225740.6_Missense_Mutation_p.W57L|ALDH3A1_ENST00000395555.3_Missense_Mutation_p.W57L|ALDH3A1_ENST00000494157.2_5'UTR|ALDH3A1_ENST00000485231.1_5'UTR|ALDH3A1_ENST00000444455.1_Missense_Mutation_p.W57L	NM_001135168.1	NP_001128640.1	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3 family, member A1	57					cellular aldehyde metabolic process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase|aldehyde dehydrogenase (NAD) activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|urinary_tract(1)	13	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)	GTAGGCGTTCCATTCATTCTG	0.627000													4	89					0.00909568	0.00990317	0.009096	1	0
IGHV1-18	28468	broad.mit.edu	37	14	106641603	106641603	+	RNA	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:106641603C>T	ENST00000390605.2	-	0	369																											AGATCTCAGGCTCCTCAGCTC	0.542000													6	221					0	0	0.001984	0	0
OR1L1	26737	broad.mit.edu	37	9	125424061	125424061	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr9:125424061G>A	ENST00000373686.1	+	1	217	c.217G>A	c.(217-219)Gat>Aat	p.D73N				Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L, member 1	73					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)	17						TCGACCTGAGGATCAGAAGCC	0.478000													4	49					0	0	0.009096	0	0
RCL1	10171	broad.mit.edu	37	9	4826886	4826886	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr9:4826886C>T	ENST00000381750.4	+	3	460	c.237C>T	c.(235-237)ctC>ctT	p.L79L	RCL1_ENST00000381732.3_Silent_p.L79L	NM_005772.3	NP_005763.3	Q9Y2P8	RCL1_HUMAN	RNA terminal phosphate cyclase-like 1	79					ribosome biogenesis|RNA processing	nucleolus	RNA-3'-phosphate cyclase activity			breast(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	9	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0206)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0244)		AGCCTGGCCTCCTGTATGGTG	0.438000													12	190					0	0	0.010729	0	0
MYH2	4620	broad.mit.edu	37	17	10440596	10440596	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:10440596C>T	ENST00000245503.5	-	16	2235	c.1851G>A	c.(1849-1851)atG>atA	p.M617I	MYH2_ENST00000532183.1_Missense_Mutation_p.M617I|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.M617I	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	617	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						CTAGAGTTTTCATTGCAGACT	0.438000													8	189					0	0	0.004482	0	0
PCDH11Y	83259	broad.mit.edu	37	Y	4925237	4925237	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrY:4925237C>T	ENST00000333703.4	+	4	853	c.340C>T	c.(340-342)Cgt>Tgt	p.R114C	PCDH11Y_ENST00000215473.6_Missense_Mutation_p.R125C|PCDH11Y_ENST00000362095.5_Missense_Mutation_p.R125C	NM_001278619.1|NM_032971.2	NP_001265548.1|NP_116753.1	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked	125	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			autonomic_ganglia(1)|kidney(2)|large_intestine(7)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						TCGCATTGATCGTGAGAAATT	0.443000													9	79					0	0	0.006214	0	0
IQCH	64799	broad.mit.edu	37	15	67664976	67664976	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:67664976G>A	ENST00000335894.4	+	9	1347	c.1281G>A	c.(1279-1281)ctG>ctA	p.L427L	IQCH_ENST00000360277.4_Silent_p.L179L|IQCH_ENST00000546225.1_Silent_p.L175L|IQCH_ENST00000358767.3_Silent_p.L254L	NM_001031715.2	NP_001026885.1	Q86VS3	IQCH_HUMAN	IQ motif containing H	427										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		AGAGACACCTGGAGAATTTTC	0.448000													4	130					0	0	0.000602	0	0
DET1	55070	broad.mit.edu	37	15	89074606	89074606	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:89074606G>A	ENST00000564406.1	-	3	524	c.364C>T	c.(364-366)Cag>Tag	p.Q122*	DET1_ENST00000444300.1_Nonsense_Mutation_p.Q122*|DET1_ENST00000558413.1_Nonsense_Mutation_p.Q66*|DET1_ENST00000268148.8_Nonsense_Mutation_p.Q111*	NM_017996.3	NP_060466.2	Q7L5Y6	DET1_HUMAN	de-etiolated homolog 1 (Arabidopsis)	111						nucleus				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(10)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Lung NSC(78;0.105)|all_lung(78;0.182)		BRCA - Breast invasive adenocarcinoma(143;0.188)			ACTGACCGCTGGTCATTGCCA	0.532000													4	61					0	0	0.009096	0	0
OR4N2	390429	broad.mit.edu	37	14	20296445	20296445	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:20296445C>T	ENST00000315947.1	+	1	838	c.838C>T	c.(838-840)Cct>Tct	p.P280S	OR4N2_ENST00000568211.1_3'UTR	NM_001004723.1	NP_001004723.1	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	280					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGTGATTTTTCCTTTGTTGAA	0.438000													5	99					0	0	0.000602	0	0
OR8H3	390152	broad.mit.edu	37	11	55890037	55890037	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr11:55890037C>T	ENST00000313472.3	+	1	189	c.189C>T	c.(187-189)ttC>ttT	p.F63F		NM_001005201.1	NP_001005201.1	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H, member 3	63					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(30)|ovary(2)|prostate(1)|skin(3)|stomach(1)	42	Esophageal squamous(21;0.00693)					TGTATTTTTTCCTTACTCACC	0.428000													8	258					0	0	0.006214	0	0
RHBDL1	9028	broad.mit.edu	37	16	727045	727045	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr16:727045G>A	ENST00000219551.2	+	3	723	c.696G>A	c.(694-696)aaG>aaA	p.K232K	RHBDL1_ENST00000352681.3_Silent_p.K167K			O75783	RHBL1_HUMAN	rhomboid, veinlet-like 1 (Drosophila)	232					proteolysis|signal transduction	integral to plasma membrane|membrane fraction	calcium ion binding|serine-type endopeptidase activity			endometrium(1)|kidney(1)|lung(4)|urinary_tract(3)	9		Hepatocellular(780;0.0218)				AGTACATGAAGAGCCCCCTTG	0.622000													4	43					0	0	0.000602	0	0
ZPBP	11055	broad.mit.edu	37	7	50121463	50121463	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:50121463G>A	ENST00000046087.2	-	3	310	c.241C>T	c.(241-243)Cca>Tca	p.P81S	ZPBP_ENST00000419417.1_Missense_Mutation_p.P81S	NM_001159878.1|NM_007009.2	NP_001153350.1|NP_008940.2	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein	81					binding of sperm to zona pellucida	extracellular region				NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(3)	29	Glioma(55;0.08)|all_neural(89;0.245)					AACACGTGTGGACTCTTTTGA	0.358000													4	45					0	0	0.009096	0	0
SPATA8	145946	broad.mit.edu	37	15	97328248	97328248	+	Missense_Mutation	SNP	G	G	A	rs145348357		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:97328248G>A	ENST00000558553.1	+	3	246	c.97G>A	c.(97-99)Gat>Aat	p.D33N	SPATA8_ENST00000328504.3_Silent_p.R73R			Q6RVD6	SPAT8_HUMAN	spermatogenesis associated 8	0								p.R73R(1)		large_intestine(4)|lung(8)|ovary(1)|skin(3)	16	Melanoma(26;0.0142)|Lung NSC(78;0.041)|all_lung(78;0.0468)		OV - Ovarian serous cystadenocarcinoma(32;0.0718)			CTCACGGAAGGATCCAAAGGG	0.453000													5	115					0	0	0.001168	0	0
PDHA2	5161	broad.mit.edu	37	4	96761738	96761738	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr4:96761738G>A	ENST00000295266.4	+	1	500	c.437G>A	c.(436-438)gGa>gAa	p.G146E		NM_005390.4	NP_005381.1	P29803	ODPAT_HUMAN	pyruvate dehydrogenase (lipoamide) alpha 2	146					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity	p.G146E(1)		NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(23)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	46		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	TGTGCTAAAGGAAAAGGAGGA	0.532000													4	60					0	0	0.009096	0	0
OR52B2	255725	broad.mit.edu	37	11	6190586	6190586	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr11:6190586C>T	ENST00000530810.1	-	1	1052	c.971G>A	c.(970-972)tGa>tAa	p.*324*	RP11-290F24.3_ENST00000529961.1_RNA	NM_001004052.1	NP_001004052.1	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B, member 2	0					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(3)|endometrium(1)|large_intestine(1)|lung(15)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CATGAAGATTCATGAGCCCAG	0.468000													6	69					0	0	0.001168	0	0
PLXNA4	91584	broad.mit.edu	37	7	131878833	131878833	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:131878833G>A	ENST00000359827.3	-	14	3806	c.2844C>T	c.(2842-2844)ctC>ctT	p.L948L	PLXNA4_ENST00000321063.4_Silent_p.L948L			Q9HCM2	PLXA4_HUMAN	plexin A4	948	IPT/TIG 1.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						TGAAGTAATAGAGCTGTGAGG	0.582000													4	51					0	0	0.000602	0	0
HS6ST1	9394	broad.mit.edu	37	2	129026429	129026429	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:129026429G>A	ENST00000259241.6	-	2	556	c.543C>T	c.(541-543)atC>atT	p.I181I		NM_004807.2	NP_004798.3	O60243	H6ST1_HUMAN	heparan sulfate 6-O-sulfotransferase 1	181					heparan sulfate proteoglycan biosynthetic process, enzymatic modification	integral to plasma membrane	sulfotransferase activity			endometrium(3)|liver(1)|lung(7)|pancreas(1)|prostate(2)|skin(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.117)		GTAGCAGGGTGATGTAGTAGA	0.612000													6	35					0	0	0.001168	0	0
ZXDA	7789	broad.mit.edu	37	X	57934541	57934541	+	Missense_Mutation	SNP	A	A	C			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:57934541A>C	ENST00000358697.4	-	1	2526	c.2314T>G	c.(2314-2316)Ttt>Gtt	p.F772V		NM_007156.4	NP_009087.1	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	772					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(13)|ovary(2)|prostate(2)|skin(1)	37						GGGAATCCAAACTGGGTTTCT	0.453000													6	36					0	0	0.001168	0	0
MOB3C	148932	broad.mit.edu	37	1	47075794	47075794	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:47075794G>A	ENST00000371940.1	-	2	3644	c.570C>T	c.(568-570)atC>atT	p.I190I	MOB3C_ENST00000319928.3_Silent_p.I167I|MOB3C_ENST00000477318.1_5'UTR|MKNK1_ENST00000545730.1_Intron|MOB3C_ENST00000271139.8_Silent_p.I219I			Q70IA8	MOL2C_HUMAN	MOB kinase activator 3C	167							metal ion binding										CGAAGTGGTGGATGTAGACAT	0.562000													5	98					0	0	0.000602	0	0
SLIT1	6585	broad.mit.edu	37	10	98763970	98763970	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr10:98763970C>T	ENST00000266058.4	-	34	3965	c.3720G>A	c.(3718-3720)acG>acA	p.T1240T	ARHGAP19-SLIT1_ENST00000453547.2_3'UTR|SLIT1_ENST00000371070.4_Silent_p.T1240T	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	1240	Laminin G-like.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		CATCGTTGATCGTCTCAGCAC	0.572000													5	166					0	0	0.001168	0	0
RIOK1	83732	broad.mit.edu	37	6	7405486	7405486	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:7405486C>T	ENST00000379834.2	+	12	1608	c.1101C>T	c.(1099-1101)ttC>ttT	p.F367F		NM_031480.2|NM_153005.1	NP_113668.2|NP_694550.1	Q9BRS2	RIOK1_HUMAN	RIO kinase 1	367	Protein kinase.						ATP binding|protein serine/threonine kinase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	19	Ovarian(93;0.0418)					TGACAGATTTCTTTATGAGGC	0.363000													4	34					0	0	0.000602	0	0
PLA2G4D	283748	broad.mit.edu	37	15	42386655	42386655	+	Translation_Start_Site	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:42386655C>T	ENST00000290472.3	-	1	97	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_178034.3	NP_828848.3	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD (cytosolic)	1					phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		ACAGGCTCTCCATGCTAGCCC	0.637000													4	57					0	0	0.000602	0	0
KCNK9	51305	broad.mit.edu	37	8	140630831	140630831	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr8:140630831G>A	ENST00000520439.1	-	2	858	c.795C>T	c.(793-795)gcC>gcT	p.A265A	KCNK9_ENST00000303015.1_Silent_p.A265A			Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	265						integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(9)|kidney(1)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)	43	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			TGCGGTTTCCGGCGAGGGATG	0.627000													6	65					0	0	0.001168	0	0
OR1L8	138881	broad.mit.edu	37	9	125330478	125330478	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr9:125330478G>A	ENST00000304865.2	-	1	360	c.279C>T	c.(277-279)atC>atT	p.I93I		NM_001004454.1	NP_001004454.1	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L, member 8	93					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						CAGCATAGGAGATGGTCTTCT	0.463000													8	78					0	0	0.003080	0	0
CARS	833	broad.mit.edu	37	11	3041490	3041490	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr11:3041490G>A	ENST00000397114.3	-	11	1323	c.947C>T	c.(946-948)tCt>tTt	p.S316F	CARS_ENST00000397111.5_Missense_Mutation_p.S326F|CARS_ENST00000278224.9_Missense_Mutation_p.S326F|CARS_ENST00000380525.4_Missense_Mutation_p.S409F|CARS_ENST00000401769.3_Missense_Mutation_p.S339F			P49589	SYCC_HUMAN	cysteinyl-tRNA synthetase	326					cysteinyl-tRNA aminoacylation	cytoplasm|cytosol	ATP binding|cysteine-tRNA ligase activity|metal ion binding|protein homodimerization activity|tRNA binding		CARS/ALK(5)	central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)	31		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00317)|LUSC - Lung squamous cell carcinoma(625;0.218)	L-Cysteine(DB00151)	TCCGGGCTTAGAGGCCTTCCA	0.627000			T	ALK	ALCL								5	75					0	0	0.001984	0	0
FSIP2	401024	broad.mit.edu	37	2	186671831	186671831	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:186671831C>T	ENST00000343098.5	+	17	18065	c.18065C>T	c.(18064-18066)tCt>tTt	p.S6022F	FSIP2_ENST00000424728.1_Missense_Mutation_p.S5933F	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						TCTCAAGACTCTATTTGGAAG	0.308000													4	73					0	0	0.009096	0	0
GNAT2	2780	broad.mit.edu	37	1	110146621	110146621	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:110146621C>T	ENST00000351050.3	-	7	1012	c.826G>A	c.(826-828)Gaa>Aaa	p.E276K		NM_005272.3	NP_005263.1	P19087	GNAT2_HUMAN	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2	276					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	G-protein beta/gamma-subunit complex binding|G-protein coupled photoreceptor activity|G-protein-coupled receptor binding|GTP binding|GTPase activity	p.E276K(1)		NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	14		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0422)|Colorectal(144;0.108)|Epithelial(280;0.125)|all cancers(265;0.129)|LUSC - Lung squamous cell carcinoma(189;0.227)		TTGATTTTTTCCTCAAAGAGG	0.393000													6	53					0	0	0.001168	0	0
SYDE2	84144	broad.mit.edu	37	1	85656401	85656401	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:85656401C>T	ENST00000341460.5	-	2	829	c.780G>A	c.(778-780)aaG>aaA	p.K260K		NM_032184.1	NP_115560.1	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2 (C. elegans)	260					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)	20				all cancers(265;0.0126)|Epithelial(280;0.0336)		GTTCTCTTCCCTTCATTGAAG	0.358000													5	174					0	0	0.000602	0	0
MUC16	94025	broad.mit.edu	37	19	9060704	9060704	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:9060704G>A	ENST00000397910.4	-	3	26945	c.26742C>T	c.(26740-26742)atC>atT	p.I8914I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8916	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CATCTGAGGTGATATTCATAC	0.498000													6	164					0	0	0.001984	0	0
MDM4	4194	broad.mit.edu	37	1	204518492	204518492	+	Silent	SNP	T	T	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:204518492T>A	ENST00000367182.3	+	11	1317	c.1155T>A	c.(1153-1155)ctT>ctA	p.L385L	MDM4_ENST00000454264.2_Silent_p.L335L|MDM4_ENST00000507825.2_Intron|MDM4_ENST00000367183.3_Silent_p.L59L|MDM4_ENST00000391947.2_3'UTR|MDM4_ENST00000463049.1_3'UTR	NM_001204171.1|NM_001278516.1|NM_001278517.1|NM_001278518.1|NM_001278519.1|NM_002393.4	NP_001191100.1|NP_001265445.1|NP_001265446.1|NP_001265447.1|NP_001265448.1|NP_002384.2	O15151	MDM4_HUMAN	Mdm4 p53 binding protein homolog (mouse)	385					apoptosis|cell proliferation|cellular response to hypoxia|G0 to G1 transition|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of protein catabolic process|negative regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization	nucleus	enzyme binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	16	all_cancers(21;0.00146)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.112)|all_epithelial(62;0.118)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;3.15e-47)|all cancers(3;3.56e-32)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|Epithelial(59;0.143)|BRCA - Breast invasive adenocarcinoma(75;0.143)			ACTCCAAACTTTTTGATCCCT	0.413000			A		"""GBM, bladder, retinoblastoma"""								5	93					0	0	0.001168	0	0
ANKRD16	54522	broad.mit.edu	37	10	5920125	5920125	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr10:5920125G>A	ENST00000380094.5	-	7	1597	c.1054C>T	c.(1054-1056)Ctt>Ttt	p.L352F	ANKRD16_ENST00000380092.4_Missense_Mutation_p.L352F|ANKRD16_ENST00000191063.8_3'UTR	NM_019046.2	NP_061919.1	Q6P6B7	ANR16_HUMAN	ankyrin repeat domain 16	352										breast(1)|endometrium(1)|large_intestine(5)|lung(3)|stomach(2)	12						GAGCCCTGAAGGACATCTGCT	0.512000													5	216					0	0	0.000602	0	0
ZIM3	114026	broad.mit.edu	37	19	57648268	57648268	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:57648268C>T	ENST00000269834.1	-	4	599	c.214G>A	c.(214-216)Gag>Aag	p.E72K		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	72	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGCACTTCCTCTTCCTCCAAC	0.522000													5	87					0	0	0.000602	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269887	150269887	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:150269887C>T	ENST00000255945.2	+	3	904	c.729C>T	c.(727-729)ctC>ctT	p.L243L	GIMAP4_ENST00000461940.1_Silent_p.L257L|GIMAP4_ENST00000494750.1_3'UTR	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	243							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGCAAGAACTCCACAGAGTGG	0.483000													4	32					0	0	0.009096	0	0
COL15A1	1306	broad.mit.edu	37	9	101797632	101797632	+	Splice_Site	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr9:101797632G>A	ENST00000375001.3	+	19	2644	c.2220_splice	c.e19-1	p.D741_splice		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	741	Nonhelical region 3 (NC3).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				CCTTCCCCAGGATACCGAAGG	0.532000													5	78					0	0	0.000602	0	0
SAGE1	55511	broad.mit.edu	37	X	134993456	134993456	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:134993456G>A	ENST00000535938.1	+	17	2278	c.2111G>A	c.(2110-2112)gGa>gAa	p.G704E	SAGE1_ENST00000370709.3_Missense_Mutation_p.G704E|SAGE1_ENST00000324447.3_Missense_Mutation_p.G704E|SAGE1_ENST00000537770.1_Missense_Mutation_p.G328E	NM_018666.2	NP_061136.2	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	704										breast(5)|endometrium(5)|large_intestine(10)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	55	Acute lymphoblastic leukemia(192;0.000127)					AATCTGTCAGGAGCTGGTATT	0.468000													7	54					0	0	0.001984	0	0
LOC645752	645752	broad.mit.edu	37	15	78212571	78212571	+	RNA	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:78212571G>A	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCTGTGTCACGTGTGCGTTCA	0.572000													4	40					0	0	0.000602	0	0
C3	718	broad.mit.edu	37	19	6696669	6696669	+	Splice_Site	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:6696669G>A	ENST00000245907.6	-	22	2890	c.2796_splice	c.e22-1	p.P933_splice		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	933					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GATTCCTTCCGGCTACGCAGT	0.572000													7	172					0	0	0.003080	0	0
HDAC11	79885	broad.mit.edu	37	3	13544405	13544405	+	Missense_Mutation	SNP	T	T	C			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:13544405T>C	ENST00000295757.3	+	8	757	c.574T>C	c.(574-576)Ttc>Ctc	p.F192L	HDAC11_ENST00000404548.1_Intron|HDAC11_ENST00000404040.1_Missense_Mutation_p.F92L|HDAC11_ENST00000402259.1_Intron|HDAC11_ENST00000402271.1_Missense_Mutation_p.F113L|HDAC11_ENST00000446613.2_5'UTR|HDAC11_ENST00000495099.2_3'UTR|HDAC11_ENST00000433119.1_Silent_p.T149T|HDAC11_ENST00000437379.2_Missense_Mutation_p.F164L|HDAC11_ENST00000522202.1_Missense_Mutation_p.F141L|HDAC11_ENST00000405025.1_Intron	NM_024827.3	NP_079103.2	Q96DB2	HDA11_HUMAN	histone deacetylase 11	192	Histone deacetylase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex|plasma membrane	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(4)|prostate(3)	13						TGAGCGAGACTTCATGGACGA	0.612000													7	255					0	0	0.003080	0	0
OR52I1	390037	broad.mit.edu	37	11	4615434	4615434	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr11:4615434G>A	ENST00000450052.2	+	2	238	c.238G>A	c.(238-240)Gat>Aat	p.D80N	OR52I1_ENST00000530443.2_Missense_Mutation_p.D56N			Q8NGK6	O52I1_HUMAN	olfactory receptor, family 52, subfamily I, member 1	56					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	15		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;7.98e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		AATCTGGATGGATTCCACTCG	0.502000													7	134					0	0	0.001984	0	0
MKI67	4288	broad.mit.edu	37	10	129906972	129906972	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr10:129906972G>A	ENST00000368654.3	-	13	3507	c.3132C>T	c.(3130-3132)ttC>ttT	p.F1044F	MKI67_ENST00000368653.3_Silent_p.F684F	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	1044	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				ACGTCCGTGTGAACTTGCCGA	0.522000													10	296					0	0	0.010729	0	0
CSMD1	64478	broad.mit.edu	37	8	2813237	2813237	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr8:2813237C>T	ENST00000520002.1	-	65	10426	c.9871G>A	c.(9871-9873)Gat>Aat	p.D3291N	CSMD1_ENST00000602723.1_Missense_Mutation_p.D3114N|CSMD1_ENST00000400186.3_Missense_Mutation_p.D3114N|CSMD1_ENST00000602557.1_Missense_Mutation_p.D3291N|CSMD1_ENST00000542608.1_Missense_Mutation_p.D3113N|CSMD1_ENST00000537824.1_Missense_Mutation_p.D3290N			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3291	Sushi 28.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTAGGAAGATCGATGGCTCTC	0.473000													6	94					0	0	0.001168	0	0
WIF1	11197	broad.mit.edu	37	12	65462650	65462650	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr12:65462650C>T	ENST00000286574.4	-	4	806	c.432G>A	c.(430-432)caG>caA	p.Q144Q		NM_007191.4	NP_009122.2	Q9Y5W5	WIF1_HUMAN	WNT inhibitory factor 1	144	WIF.				multicellular organismal development|Wnt receptor signaling pathway	extracellular region	protein tyrosine kinase activity			cervix(1)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	21			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0231)		CCACCCCATCCTGTTTTCCAA	0.358000			T	HMGA2	pleomorphic salivary gland adenoma								4	58					0	0	0.000602	0	0
OR9G4	283189	broad.mit.edu	37	11	56510443	56510443	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr11:56510443G>A	ENST00000302957.3	-	1	844	c.845C>T	c.(844-846)tCc>tTc	p.S282F		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	282					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						CCTCTCTAGGGAGTAGGTGGA	0.468000													4	87					0	0	0.009096	0	0
PHF20L1	51105	broad.mit.edu	37	8	133790096	133790096	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr8:133790096C>T	ENST00000395386.2	+	2	321	c.22C>T	c.(22-24)Cgc>Tgc	p.R8C	PHF20L1_ENST00000395390.2_Missense_Mutation_p.R8C|PHF20L1_ENST00000395382.3_5'UTR|PHF20L1_ENST00000395376.1_Missense_Mutation_p.R8C|PHF20L1_ENST00000395383.1_Missense_Mutation_p.R8C|PHF20L1_ENST00000337920.4_Missense_Mutation_p.R8C|PHF20L1_ENST00000395379.1_Missense_Mutation_p.R8C|PHF20L1_ENST00000315808.10_Missense_Mutation_p.R8C|PHF20L1_ENST00000220847.7_5'UTR	NM_016018.4	NP_057102.4	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1	8							nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(10)|ovary(2)	15	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			GCCCCCAAATCGCCCTGGAAT	0.368000													5	87					0	0	0.001168	0	0
TAP2	6891	broad.mit.edu	37	6	32782883	32782883	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:32782883G>A	ENST00000452392.2	-	13	2293	c.2120C>T	c.(2119-2121)gCc>gTc	p.A707V	HLA-DOB_ENST00000438763.2_Missense_Mutation_p.A100V			Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0					antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding										CCCATCCACGGCCTGTCTGCT	0.592000													4	42					0	0	0.009096	0	0
NTRK2	4915	broad.mit.edu	37	9	87359971	87359971	+	Missense_Mutation	SNP	G	G	A	rs142393662		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr9:87359971G>A	ENST00000304053.6	+	11	1762	c.1279G>A	c.(1279-1281)Ggt>Agt	p.G427S	NTRK2_ENST00000359847.3_Missense_Mutation_p.G427S|NTRK2_ENST00000395866.2_Missense_Mutation_p.G271S|NTRK2_ENST00000376208.1_Missense_Mutation_p.G427S|NTRK2_ENST00000395882.1_Missense_Mutation_p.G427S|NTRK2_ENST00000323115.4_Missense_Mutation_p.G427S|NTRK2_ENST00000376214.1_Missense_Mutation_p.G427S|NTRK2_ENST00000376213.1_Missense_Mutation_p.G427S|NTRK2_ENST00000277120.3_Missense_Mutation_p.G427S	NM_001018065.2	NP_001018075.1	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	427					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	46						TGATAAAACCGGTCGGGAACA	0.458000										TSP Lung(25;0.17)			5	88					0	0	0.000602	0	0
THEMIS	387357	broad.mit.edu	37	6	128134948	128134948	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:128134948C>T	ENST00000368250.1	-	5	1099	c.601G>A	c.(601-603)Gag>Aag	p.E201K	THEMIS_ENST00000537166.1_Missense_Mutation_p.E245K|THEMIS_ENST00000368248.2_Missense_Mutation_p.E280K|THEMIS_ENST00000543064.1_Missense_Mutation_p.E280K			Q8N1K5	THMS1_HUMAN	thymocyte selection associated	280	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(3)	60						ATGGGGAACTCTTTACTAGTC	0.408000													6	111					0	0	0.001984	0	0
ASMT	438	broad.mit.edu	37	X	1742160	1742160	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:1742160C>T	ENST00000381241.3	+	2	397	c.198C>T	c.(196-198)atC>atT	p.I66I	ASMT_ENST00000381229.4_Silent_p.I66I|ASMT_ENST00000381233.3_Silent_p.I66I	NM_001171038.1|NM_004043.2	NP_001164509.1|NP_004034.2	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	66					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	16		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TGCTGGACATCTGTGTGTCCC	0.612000													5	41					0	0	0.000602	0	0
CHST12	55501	broad.mit.edu	37	7	2473134	2473134	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:2473134C>T	ENST00000258711.6	+	2	995	c.860C>T	c.(859-861)tCg>tTg	p.S287L		NM_001243794.1|NM_001243795.1|NM_018641.4	NP_001230723.1|NP_001230724.1|NP_061111.1	Q9NRB3	CHSTC_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 12	287					dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	21		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		CTGCCCGCCTCGGCGCGCGAG	0.652000													4	68					0	0	0.009096	0	0
BRINP1	1620	broad.mit.edu	37	9	121929525	121929525	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr9:121929525G>A	ENST00000265922.3	-	8	2584	c.2123C>T	c.(2122-2124)cCt>cTt	p.P708L	DBC1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		708					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						GGCCACAGGAGGGGCCAGGCG	0.562000													5	100					0	0	0.000602	0	0
OR6V1	346517	broad.mit.edu	37	7	142749644	142749644	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:142749644C>T	ENST00000418316.1	+	1	228	c.207C>T	c.(205-207)atC>atT	p.I69I		NM_001001667.1	NP_001001667.1	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V, member 1	69					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)	20	Melanoma(164;0.059)					TGCTGGAGATCTTGGTAACCA	0.493000													7	184					0	0	0.003080	0	0
RFX7	64864	broad.mit.edu	37	15	56386321	56386321	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:56386321G>A	ENST00000423270.1	-	9	3604	c.3605C>T	c.(3604-3606)cCa>cTa	p.P1202L	RFX7_ENST00000559447.2_Missense_Mutation_p.P1105L|RFX7_ENST00000422057.1_Missense_Mutation_p.P1105L|RFX7_ENST00000317318.6_Missense_Mutation_p.P1202L	NM_022841.5	NP_073752.5	Q2KHR2	RFX7_HUMAN	regulatory factor X, 7	1105					regulation of transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						ATGAACTTCTGGGGTAACTGG	0.458000													5	137					0	0	0.000602	0	0
RYR3	6263	broad.mit.edu	37	15	33962623	33962623	+	Missense_Mutation	SNP	T	T	G			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:33962623T>G	ENST00000389232.4	+	38	5796	c.5726T>G	c.(5725-5727)gTt>gGt	p.V1909G	RYR3_ENST00000415757.3_Missense_Mutation_p.V1909G	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1909	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.V1909G(1)		NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTGCTAGGGGTTCCTTTggaa	0.473000													8	30					0	0	0.003163	0	0
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													8	154					0	0	0.003080	0	0
CAMTA1	23261	broad.mit.edu	37	1	7724446	7724446	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:7724446C>T	ENST00000303635.7	+	9	2046	c.1839C>T	c.(1837-1839)tcC>tcT	p.S613S	CAMTA1_ENST00000439411.2_Silent_p.S613S	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	613					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		AGACCCCCTCCCCGAGCTTCT	0.642000			T	WWTR1	epitheliod hemangioendothelioma								5	130					0	0	0.000602	0	0
COL14A1	7373	broad.mit.edu	37	8	121381652	121381652	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr8:121381652C>T	ENST00000297848.3	+	47	5509	c.5239C>T	c.(5239-5241)Cct>Tct	p.P1747S	COL14A1_ENST00000247781.3_Missense_Mutation_p.P1652S|COL14A1_ENST00000309791.4_Missense_Mutation_p.P1747S	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1747	Triple-helical region 2 (COL1).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging	p.P1747S(1)		NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TCTGGGGGTTCCTGGACCCCA	0.597000													7	75					0	0	0.001984	0	0
TRPM4	54795	broad.mit.edu	37	19	49671280	49671280	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:49671280C>T	ENST00000252826.5	+	4	500	c.374C>T	c.(373-375)tCg>tTg	p.S125L	TRPM4_ENST00000355712.5_Intron|TRPM4_ENST00000427978.2_Missense_Mutation_p.S125L	NM_017636.3	NP_060106.2	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel, subfamily M, member 4	125					dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		CTGGGGGGATCGGGGGGCCCC	0.677000													10	139					0	0	0.006214	0	0
MYH2	4620	broad.mit.edu	37	17	10432356	10432356	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:10432356C>T	ENST00000245503.5	-	27	3779	c.3395G>A	c.(3394-3396)cGg>cAg	p.R1132Q	MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.R1132Q|CTC-297N7.7_ENST00000581304.1_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1132					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						CCGGGAGGCCCGCTCTGCCTC	0.602000													5	55					0	0	0.001168	0	0
IGSF22	283284	broad.mit.edu	37	11	18745706	18745706	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr11:18745706C>T	ENST00000513874.1	-	2	217	c.78G>A	c.(76-78)caG>caA	p.Q26Q	RP11-1081L13.4_ENST00000527285.1_RNA	NM_173588.3	NP_775859.3	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	26										NS(2)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(20)|ovary(4)|prostate(4)|skin(3)	56						GGGAGAAGGTCTGCACGTGGG	0.602000													7	124					0	0	0.001984	0	0
PPP1R9B	84687	broad.mit.edu	37	17	48216840	48216840	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:48216840G>A	ENST00000316878.6	-	8	1969	c.1967C>T	c.(1966-1968)tCc>tTc	p.S656F	AC002401.1_ENST00000451776.1_RNA|PPP1R9B_ENST00000501501.2_5'UTR	NM_032595.3	NP_115984.3	Q96SB3	NEB2_HUMAN	protein phosphatase 1, regulatory subunit 9B	656	Interacts with TGN38 (By similarity).				cell cycle arrest|cell differentiation|cell migration|filopodium assembly|negative regulation of cell growth|nervous system development|regulation of cell growth by extracellular stimulus|regulation of cell proliferation|regulation of exit from mitosis|RNA splicing	adherens junction|cytoskeleton|dendritic spine|filopodium|lamellipodium|nucleoplasm|protein phosphatase type 1 complex|ruffle membrane|synapse	actin binding|protein phosphatase 1 binding|protein phosphatase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	8						GTCCACAGGGGACAGTGCATC	0.617000													7	178					0	0	0.004482	0	0
FLRT2	23768	broad.mit.edu	37	14	86088459	86088459	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:86088459C>T	ENST00000330753.4	+	2	1368	c.601C>T	c.(601-603)Cag>Tag	p.Q201*	FLRT2_ENST00000554746.1_Nonsense_Mutation_p.Q201*	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	201					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		CATGGCCTTCCAGAATCTCAC	0.522000													5	98					0	0	0.000602	0	0
ABL2	27	broad.mit.edu	37	1	179078028	179078028	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:179078028G>A	ENST00000502732.1	-	12	2577	c.2374C>T	c.(2374-2376)Cca>Tca	p.P792S	ABL2_ENST00000344730.3_Missense_Mutation_p.P674S|ABL2_ENST00000512653.1_Missense_Mutation_p.P777S|ABL2_ENST00000507173.1_Missense_Mutation_p.P668S|ABL2_ENST00000408940.3_Missense_Mutation_p.P756S|ABL2_ENST00000511413.1_Missense_Mutation_p.P689S|ABL2_ENST00000504405.1_Missense_Mutation_p.P653S|ABL2_ENST00000367623.4_Missense_Mutation_p.P771S	NM_001168236.1|NM_001168237.1|NM_001168238.1|NM_007314.3	NP_001161708.1|NP_001161709.1|NP_001161710.1|NP_009298.1	P42684	ABL2_HUMAN	c-abl oncogene 2, non-receptor tyrosine kinase	792	F-actin-binding (By similarity).				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(8)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	65					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	TCCTGCTCTGGAAGCCCTGAG	0.517000			T	ETV6	AML								16	111					0	0	0.004990	0	0
NEB	4703	broad.mit.edu	37	2	152506779	152506779	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:152506779G>A	ENST00000427231.2	-	54	7544	c.7342C>T	c.(7342-7344)Cgt>Tgt	p.R2448C	NEB_ENST00000409198.1_Missense_Mutation_p.R2448C|NEB_ENST00000172853.10_Missense_Mutation_p.R2448C|NEB_ENST00000604864.1_Missense_Mutation_p.R2448C|NEB_ENST00000397345.3_Missense_Mutation_p.R2448C|NEB_ENST00000603639.1_Missense_Mutation_p.R2448C	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	2448					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle	p.R2448C(2)		NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GGAGGCTGACGATATTTCTTC	0.463000													4	73					0	0	0.009096	0	0
FAM171A1	221061	broad.mit.edu	37	10	15256046	15256046	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr10:15256046G>A	ENST00000378116.4	-	8	1547	c.1541C>T	c.(1540-1542)aCc>aTc	p.T514I		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	514						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						TTCCTGAATGGTGAGTTTGCT	0.512000													7	148					0	0	0.001984	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6064107	6064107	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr4:6064107G>A	ENST00000409021.3	-	10	1941	c.1492C>T	c.(1492-1494)Ctg>Ttg	p.L498L	JAKMIP1_ENST00000409831.1_Silent_p.L498L|JAKMIP1_ENST00000282924.5_Silent_p.L498L|JAKMIP1_ENST00000409371.3_Silent_p.L313L|JAKMIP1_ENST00000410077.2_Silent_p.L333L	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	498	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GCGCGTTGCAGGGCCTGGTAC	0.627000													4	79					0	0	0.009096	0	0
SUN1	23353	broad.mit.edu	37	7	909027	909027	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:909027C>T	ENST00000456758.2	+	23	2589	c.2589C>T	c.(2587-2589)tcC>tcT	p.S863S	SUN1_ENST00000401592.1_Silent_p.S674S|SUN1_ENST00000405266.1_Silent_p.S711S|SUN1_ENST00000413514.2_Silent_p.S472S|SUN1_ENST00000389574.3_Silent_p.S591S|SUN1_ENST00000425407.2_Silent_p.S591S|SUN1_ENST00000452783.2_Silent_p.S571S			O94901	SUN1_HUMAN	Sad1 and UNC84 domain containing 1	701					cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(17)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TTAAAGGCTCCCAGGGGTACC	0.547000													10	151					0	0	0.010729	0	0
TIPRL	261726	broad.mit.edu	37	1	168153168	168153168	+	Missense_Mutation	SNP	C	C	G			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:168153168C>G	ENST00000367833.2	+	2	278	c.133C>G	c.(133-135)Ctc>Gtc	p.L45V	TIPRL_ENST00000367830.3_Missense_Mutation_p.L45V	NM_152902.3	NP_690866.1	O75663	TIPRL_HUMAN	TIP41, TOR signaling pathway regulator-like (S. cerevisiae)	45					DNA damage checkpoint|negative regulation of protein phosphatase type 2A activity	cytoplasm	protein binding			breast(1)|kidney(1)|large_intestine(1)|ovary(2)|skin(1)	6	all_hematologic(923;0.215)					TATGCCATCTCTCCCTGAAAT	0.383000													4	74					0	0	0.009096	0	0
MROH7	374977	broad.mit.edu	37	1	55119589	55119589	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:55119589C>T	ENST00000414150.2	+	3	1268	c.990C>T	c.(988-990)atC>atT	p.I330I	MROH7_ENST00000421030.2_Silent_p.I330I|MROH7_ENST00000339553.5_Silent_p.I330I|MROH7_ENST00000545244.1_Intron|MROH7_ENST00000472987.1_3'UTR|MROH7_ENST00000454855.2_Intron|MROH7_ENST00000409996.1_Intron|MROH7_ENST00000395690.2_Silent_p.I330I					maestro heat-like repeat family member 7																		TGACTCTAATCCTGGGTTCCA	0.557000													5	90					0	0	0.000602	0	0
KBTBD8	84541	broad.mit.edu	37	3	67054691	67054691	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:67054691C>T	ENST00000295568.4	+	3	1353	c.1222C>T	c.(1222-1224)Cat>Tat	p.H408Y	KBTBD8_ENST00000417314.2_Missense_Mutation_p.H434Y|KBTBD8_ENST00000460576.1_Intron	NM_032505.2	NP_115894.2	Q8NFY9	KBTB8_HUMAN	kelch repeat and BTB (POZ) domain containing 8	434										breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)	20		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		AATGGAATTTCATAATGCTGT	0.413000													7	114					0	0	0.001984	0	0
KCNJ5	3762	broad.mit.edu	37	11	128781607	128781607	+	Missense_Mutation	SNP	G	G	A	rs148355179		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr11:128781607G>A	ENST00000529694.1	+	2	815	c.439G>A	c.(439-441)Gaa>Aaa	p.E147K	KCNJ5_ENST00000533599.1_Missense_Mutation_p.E147K|KCNJ5_ENST00000338350.4_Missense_Mutation_p.E147K	NM_000890.3	NP_000881.3	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 5	147					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding	p.E147K(1)		NS(1)|breast(1)|endometrium(4)|large_intestine(4)|liver(2)|lung(9)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	CATTGAGACCGAAACAACCAT	0.527000													6	133					0	0	0.003080	0	0
CDC20	991	broad.mit.edu	37	1	43825722	43825722	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:43825722C>T	ENST00000372462.1	+	4	713	c.510C>T	c.(508-510)tcC>tcT	p.S170S	CDC20_ENST00000478882.1_3'UTR|CDC20_ENST00000310955.6_Silent_p.S170S			Q12834	CDC20_HUMAN	cell division cycle 20	170					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	cytosol|nucleoplasm|spindle	enzyme binding|protein C-terminus binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	15	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ACATTCCTTCCCTGCCAGACC	0.532000													9	199					0	0	0.001855	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140720636	140720636	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr5:140720636G>A	ENST00000394576.2	+	1	2098	c.2098G>A	c.(2098-2100)Gtc>Atc	p.V700I	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGGCCGCGGTCTCCTGCGT	0.662000													5	163					0	0	0.000602	0	0
DYSF	8291	broad.mit.edu	37	2	71795405	71795405	+	Missense_Mutation	SNP	A	A	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:71795405A>T	ENST00000258104.3	+	26	3024	c.2747A>T	c.(2746-2748)gAc>gTc	p.D916V	DYSF_ENST00000409651.1_Missense_Mutation_p.D948V|DYSF_ENST00000394120.2_Missense_Mutation_p.D917V|DYSF_ENST00000409744.1_Missense_Mutation_p.D903V|DYSF_ENST00000429174.2_Missense_Mutation_p.D916V|DYSF_ENST00000410020.3_Missense_Mutation_p.D934V|DYSF_ENST00000410041.1_Missense_Mutation_p.D934V|DYSF_ENST00000409762.1_Missense_Mutation_p.D933V|DYSF_ENST00000409366.1_Missense_Mutation_p.D917V|DYSF_ENST00000413539.2_Missense_Mutation_p.D947V|DYSF_ENST00000409582.3_Missense_Mutation_p.D933V	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	916						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						CTACCCAAGGACAGCTTCCGC	0.622000													7	368					0	0	0.001984	0	0
PUM1	9698	broad.mit.edu	37	1	31406064	31406064	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:31406064G>A	ENST00000373747.3	-	22	3663	c.3564C>T	c.(3562-3564)atC>atT	p.I1188I	PUM1_ENST00000257075.5_Silent_p.I1185I|PUM1_ENST00000440538.2_Silent_p.I1161I|PUM1_ENST00000373741.4_Silent_p.I1223I|PUM1_ENST00000424085.2_Silent_p.I943I|PUM1_ENST00000373742.2_Silent_p.I1126I|PUM1_ENST00000423018.2_Silent_p.I1043I|PUM1_ENST00000426105.2_Silent_p.I1187I	NM_001020658.1	NP_001018494.1	Q14671	PUM1_HUMAN	pumilio RNA-binding family member 1	1185					cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(17)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		TGCCTCAGATGATACCATTAG	0.522000													6	127					0	0	0.001984	0	0
CSNK1E	1454	broad.mit.edu	37	22	38696918	38696918	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr22:38696918G>A	ENST00000396832.1	-	5	636	c.376C>T	c.(376-378)Cac>Tac	p.H126Y	CSNK1E_ENST00000359867.3_Missense_Mutation_p.H126Y|CSNK1E_ENST00000413574.2_Missense_Mutation_p.H126Y|CSNK1E_ENST00000405675.3_Missense_Mutation_p.H126Y|CSNK1E_ENST00000403904.1_Missense_Mutation_p.H126Y|CSNK1E_ENST00000400206.2_Missense_Mutation_p.H126Y	NM_152221.2	NP_689407.1	P49674	KC1E_HUMAN	casein kinase 1, epsilon	126	Protein kinase.				DNA repair|G2/M transition of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|signal transduction	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22	Melanoma(58;0.045)					ACGTCCCGGTGGATGAAGTTC	0.597000													7	65					0	0	0.003080	0	0
SNHG14	104472715	broad.mit.edu	37	15	25477542	25477542	+	RNA	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:25477542G>A	ENST00000453082.2	+	0	1700				SNORD115-34_ENST00000362441.1_RNA	NR_003343.1																						TTGGGTCAATGATGAGAACCT	0.498000													7	223					0	0	0.006214	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12919918	12919918	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:12919918C>T	ENST00000240189.2	+	3	745	c.658C>T	c.(658-660)Ctg>Ttg	p.L220L		NM_023014.1	NP_075390.1	O60811	PRAM2_HUMAN	PRAME family member 2	220										breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(22)|prostate(6)|skin(3)|upper_aerodigestive_tract(4)	42	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CTGGCCACATCTGATAAGAAA	0.378000													6	115					0	0	0.001168	0	0
PKHD1	5314	broad.mit.edu	37	6	51774190	51774190	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:51774190G>A	ENST00000371117.3	-	40	6848	c.6573C>T	c.(6571-6573)tcC>tcT	p.S2191S	PKHD1_ENST00000340994.4_Silent_p.S2191S	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	2191					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CTTCTGGGAAGGACTGAACGA	0.498000													8	198					0	0	0.003080	0	0
KIAA0355	9710	broad.mit.edu	37	19	34833122	34833122	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:34833122C>T	ENST00000299505.6	+	10	3156	c.2283C>T	c.(2281-2283)tcC>tcT	p.S761S		NM_014686.3	NP_055501.2	O15063	K0355_HUMAN	KIAA0355	761										breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	41	Esophageal squamous(110;0.162)					ATGGCTCATCCCAGCAGCCAG	0.582000													7	150					0	0	0.001984	0	0
PCDH18	54510	broad.mit.edu	37	4	138453224	138453224	+	Missense_Mutation	SNP	T	T	G			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr4:138453224T>G	ENST00000344876.4	-	1	405	c.19A>C	c.(19-21)Aaa>Caa	p.K7Q	PCDH18_ENST00000412923.2_Missense_Mutation_p.K7Q|PCDH18_ENST00000507846.1_Intron|PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000510305.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	7					brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					AAGTGCATTTTAGCATTCATT	0.388000													4	76					0	0	0.001984	0	0
FAM47C	442444	broad.mit.edu	37	X	37027685	37027685	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:37027685C>T	ENST00000358047.3	+	1	1254	c.1202C>T	c.(1201-1203)cCt>cTt	p.P401L		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	401										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GGAGTGTCTCCTCTCTTCCCG	0.617000													4	32					0	0	0.001168	0	0
OR10Q1	219960	broad.mit.edu	37	11	57995415	57995415	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr11:57995415G>A	ENST00000316770.2	-	1	975	c.933C>T	c.(931-933)atC>atT	p.I311I		NM_001004471.2	NP_001004471.1	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q, member 1	311					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)	35		Breast(21;0.0589)				CTGCTTTACGGATAATGGCAC	0.493000													6	201					0	0	0.003080	0	0
APOB	338	broad.mit.edu	37	2	21229891	21229891	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:21229891G>A	ENST00000233242.1	-	26	9976	c.9849C>T	c.(9847-9849)ttC>ttT	p.F3283F		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3283					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTAGGATGGAGAAACTAGGCA	0.463000													18	538					0	0	0.007413	0	0
STAU1	6780	broad.mit.edu	37	20	47741135	47741135	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr20:47741135G>A	ENST00000371828.3	-	7	861	c.374C>T	c.(373-375)cCt>cTt	p.P125L	STAU1_ENST00000340954.7_Intron|STAU1_ENST00000371856.2_Intron|STAU1_ENST00000371792.1_Intron|STAU1_ENST00000360426.4_Intron|STAU1_ENST00000371802.1_Missense_Mutation_p.P125L|STAU1_ENST00000347458.5_Intron	NM_001037328.1|NM_004602.2	NP_001032405.1|NP_004593.2	O95793	STAU1_HUMAN	staufen double-stranded RNA binding protein 1	203	DRBM 1.					microtubule associated complex|rough endoplasmic reticulum|stress granule	double-stranded RNA binding			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|liver(1)|lung(6)|ovary(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	23			BRCA - Breast invasive adenocarcinoma(12;0.000644)|Colorectal(8;0.198)			CTGTTTCAGAGGGAAAGACTG	0.537000													5	74					0	0	0.001984	0	0
PCDH20	64881	broad.mit.edu	37	13	61987027	61987027	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr13:61987027C>T	ENST00000409186.1	-	5	3310	c.1205G>A	c.(1204-1206)gGa>gAa	p.G402E	PCDH20_ENST00000409204.4_Missense_Mutation_p.G402E			Q8N6Y1	PCD20_HUMAN	protocadherin 20	375	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GCAGCCTGGTCCATTAGCAAG	0.423000													6	97					0	0	0.001984	0	0
GRID2	2895	broad.mit.edu	37	4	94693356	94693356	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr4:94693356C>T	ENST00000282020.4	+	16	2989	c.2731C>T	c.(2731-2733)Cca>Tca	p.P911S	GRID2_ENST00000510992.1_Missense_Mutation_p.P816S	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	911					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity	p.P911S(1)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TGACACTTTGCCAACACGACA	0.463000													5	109					0	0	0.000602	0	0
SLC4A2	6522	broad.mit.edu	37	7	150764057	150764057	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:150764057C>T	ENST00000485713.1	+	7	1983	c.943C>T	c.(943-945)Cgg>Tgg	p.R315W	SLC4A2_ENST00000461735.1_Missense_Mutation_p.R301W|SLC4A2_ENST00000392826.2_Missense_Mutation_p.R306W|SLC4A2_ENST00000413384.2_Missense_Mutation_p.R315W|SLC4A2_ENST00000310317.5_Missense_Mutation_p.R233W	NM_001199692.1	NP_001186621.1	P04920	B3A2_HUMAN	solute carrier family 4 (anion exchanger), member 2	315	Pro-rich.				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(14)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	33			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGCCCGACCCCGGGCCCCCCA	0.637000													4	81					0	0	0.000602	0	0
UBIAD1	29914	broad.mit.edu	37	1	11346014	11346014	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:11346014C>T	ENST00000376810.5	+	2	1169	c.843C>T	c.(841-843)atC>atT	p.I281I	UBIAD1_ENST00000376804.2_Intron	NM_013319.2	NP_037451.1	Q9Y5Z9	UBIA1_HUMAN	UbiA prenyltransferase domain containing 1	281					menaquinone biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrion|nucleus	prenyltransferase activity			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(3)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.012)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.52e-06)|COAD - Colon adenocarcinoma(227;0.000254)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0487)		ACTGCACCATCAGCCTGGCAC	0.572000													7	140					0	0	0.003080	0	0
KCNJ6	3763	broad.mit.edu	37	21	39087225	39087225	+	Missense_Mutation	SNP	C	C	T	rs143219969		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr21:39087225C>T	ENST00000400482.3	-	3	824	c.235G>A	c.(235-237)Gat>Aat	p.D79N	KCNJ6_ENST00000288309.6_Missense_Mutation_p.D79N	NM_002240.3	NP_002231.1	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 6	79					synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding	p.D79N(2)		breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22					Halothane(DB01159)	GTGAAGATATCGGTCAGGTAG	0.463000													6	106					0	0	0.003080	0	0
A4GALT	53947	broad.mit.edu	37	22	43089624	43089624	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr22:43089624C>T	ENST00000401850.1	-	2	823	c.334G>A	c.(334-336)Gtc>Atc	p.V112I	A4GALT_ENST00000249005.2_Missense_Mutation_p.V112I|A4GALT_ENST00000381278.3_Missense_Mutation_p.V112I			Q9NPC4	A4GAT_HUMAN	alpha 1,4-galactosyltransferase	112					glycosphingolipid biosynthetic process|plasma membrane organization	Golgi stack|integral to Golgi membrane|membrane fraction	lactosylceramide 4-alpha-galactosyltransferase activity			NS(1)|central_nervous_system(2)|large_intestine(6)|skin(1)|urinary_tract(1)	11						TTCATCAGGACCAGCACGTGG	0.607000													8	141					0	0	0.008291	0	0
VN1R2	317701	broad.mit.edu	37	19	53762788	53762788	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:53762788G>A	ENST00000341702.3	+	1	1244	c.1160G>A	c.(1159-1161)cGa>cAa	p.R387Q	VN1R2_ENST00000598458.1_Intron	NM_173856.2	NP_776255.2	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	387					response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(134;0.00301)		AGAAATAGACGATTCTTTCAT	0.438000													7	107					0	0	0.001984	0	0
LILRB5	10990	broad.mit.edu	37	19	54754843	54754843	+	Missense_Mutation	SNP	A	A	G			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:54754843A>G	ENST00000450632.1	-	13	1869	c.1792T>C	c.(1792-1794)Tcc>Ccc	p.S598P	LILRB5_ENST00000345866.6_Intron|LILRB5_ENST00000316219.5_Intron|LILRB5_ENST00000449561.2_Intron			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	423					cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGGGGTGGGGAGGCCTGGGGG	0.607000													4	42					0	0	0.009096	0	0
THADA	63892	broad.mit.edu	37	2	43520263	43520263	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:43520263G>A	ENST00000405006.4	-	32	4879	c.4528C>T	c.(4528-4530)Cca>Tca	p.P1510S	THADA_ENST00000330266.7_Intron|THADA_ENST00000415080.2_Missense_Mutation_p.P1191S|THADA_ENST00000405975.2_Missense_Mutation_p.P1510S	NM_001083953.1|NM_001271643.1	NP_001077422.1|NP_001258572.1	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	1510							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				GGCAGGCCTGGCACCTTGAAG	0.572000													16	525					0	0	0.007413	0	0
THSD7B	80731	broad.mit.edu	37	2	137814587	137814587	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:137814587G>A	ENST00000409968.1	+	3	915	c.737G>A	c.(736-738)gGa>gAa	p.G246E	THSD7B_ENST00000272643.3_Missense_Mutation_p.G246E|THSD7B_ENST00000543459.1_Missense_Mutation_p.G105E|THSD7B_ENST00000413152.2_Missense_Mutation_p.G215E					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		CTTAAGGTTGGACCATGGAGT	0.428000													6	159					0	0	0.001168	0	0
MUC16	94025	broad.mit.edu	37	19	9087697	9087697	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:9087697G>A	ENST00000397910.4	-	1	4321	c.4118C>T	c.(4117-4119)tCa>tTa	p.S1373L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1373	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAGATTGGGTGAACTTGAGAT	0.468000													6	102					0	0	0.001984	0	0
PAPPA2	60676	broad.mit.edu	37	1	176525801	176525801	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:176525801C>T	ENST00000367662.3	+	2	1507	c.343C>T	c.(343-345)Cca>Tca	p.P115S	PAPPA2_ENST00000367661.3_Missense_Mutation_p.P115S	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	115					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GACTGAAAATCCAGCAGGACT	0.547000													6	183					0	0	0.001168	0	0
CEACAM6	4680	broad.mit.edu	37	19	42265234	42265234	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:42265234G>A	ENST00000199764.6	+	3	720	c.502G>A	c.(502-504)Gaa>Aaa	p.E168K	AC011513.4_ENST00000601409.1_RNA	NM_002483.4	NP_002474.3	P40199	CEAM6_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)	168	Ig-like C2-type 1.				cell-cell signaling|signal transduction	anchored to membrane|integral to plasma membrane				breast(1)|kidney(4)|large_intestine(1)|lung(4)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	18				OV - Ovarian serous cystadenocarcinoma(3;0.00575)|all cancers(3;0.0352)|Epithelial(262;0.0797)		CTTCACCTGTGAACCTGAGGT	0.567000													12	183					0	0	0.013537	0	0
TCHHL1	126637	broad.mit.edu	37	1	152058786	152058786	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:152058786C>T	ENST00000368806.1	-	3	1436	c.1372G>A	c.(1372-1374)Gaa>Aaa	p.E458K		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	458							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			CCTTCAAGTTCAGGGTGAGTC	0.443000													6	223					0	0	0.001168	0	0
RPTN	126638	broad.mit.edu	37	1	152127905	152127905	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:152127905G>A	ENST00000316073.3	-	3	1734	c.1670C>T	c.(1669-1671)tCc>tTc	p.S557F		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	557	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						ACCGTAGTGGGAACTCTGGCC	0.517000													18	561					0	0	0.007413	0	0
CRB2	286204	broad.mit.edu	37	9	126132728	126132728	+	Missense_Mutation	SNP	C	C	T	rs138891622		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr9:126132728C>T	ENST00000373631.3	+	7	1397	c.1396C>T	c.(1396-1398)Cgc>Tgc	p.R466C	CRB2_ENST00000373629.2_Missense_Mutation_p.R134C|CRB2_ENST00000359999.3_Missense_Mutation_p.R466C	NM_173689.5	NP_775960.4	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 (Drosophila)	466	Laminin G-like 1.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(1)|endometrium(2)|lung(11)|ovary(1)|prostate(2)|skin(3)	23						ACTGAGGTTTCGCACCACACT	0.607000													4	27					0	0	0.009096	0	0
DNAH3	55567	broad.mit.edu	37	16	21073838	21073838	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr16:21073838G>A	ENST00000261383.3	-	25	3684	c.3685C>T	c.(3685-3687)Cca>Tca	p.P1229S	DNAH3_ENST00000415178.1_Missense_Mutation_p.P1229S	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1229	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TGTATGAATGGAACAGTTTCT	0.423000													5	88					0	0	0.001168	0	0
DGKG	1608	broad.mit.edu	37	3	186006599	186006599	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:186006599G>A	ENST00000265022.3	-	6	983	c.444C>T	c.(442-444)gtC>gtT	p.V148V	DGKG_ENST00000382164.4_Silent_p.V148V|DGKG_ENST00000544847.1_Silent_p.V148V|DGKG_ENST00000344484.4_Silent_p.V148V	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	148					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	AAGACCGAGGGACGGGGGGTT	0.552000													16	308					0	0	0.006122	0	0
IMPDH1	3614	broad.mit.edu	37	7	128038621	128038621	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:128038621G>A	ENST00000338791.6	-	10	1271	c.921C>T	c.(919-921)atC>atT	p.I307I	IMPDH1_ENST00000354269.5_Silent_p.I297I|IMPDH1_ENST00000348127.6_Silent_p.I271I|IMPDH1_ENST00000343214.4_Silent_p.I197I|IMPDH1_ENST00000496200.1_Silent_p.I197I|IMPDH1_ENST00000470772.1_Silent_p.I221I|IMPDH1_ENST00000480861.1_Silent_p.I217I|IMPDH1_ENST00000419067.2_Silent_p.I274I|IMPDH1_ENST00000378717.4_Silent_p.I238I	NM_000883.3	NP_000874.2	P20839	IMDH1_HUMAN	IMP (inosine 5'-monophosphate) dehydrogenase 1	222					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	DNA binding|IMP dehydrogenase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)	22					Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)|Ribavirin(DB00811)|Thioguanine(DB00352)	CGGTGCGGGCGATGATGGCCA	0.582000											OREG0018292	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	127					0	0	0.003080	0	0
ATG7	10533	broad.mit.edu	37	3	11406184	11406184	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:11406184C>T	ENST00000354449.3	+	16	1876	c.1851C>T	c.(1849-1851)acC>acT	p.T617T	ATG7_ENST00000354956.5_Silent_p.T617T|ATG7_ENST00000446450.2_Silent_p.T578T	NM_006395.2	NP_006386.1	O95352	ATG7_HUMAN	autophagy related 7	617					autophagy|cellular membrane fusion|positive regulation of protein modification process|protein lipidation|protein transport	cytoplasm	APG12 activating enzyme activity|protein homodimerization activity|ubiquitin activating enzyme activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(14)|prostate(1)|skin(2)|urinary_tract(1)	34						AGCCTCCAACCTCTCTTGGGC	0.488000													7	123					0	0	0.001984	0	0
KCNH1	3756	broad.mit.edu	37	1	210856890	210856890	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:210856890C>T	ENST00000367007.4	-	11	2791	c.2622G>A	c.(2620-2622)caG>caA	p.Q874Q	KCNH1_ENST00000271751.4_Silent_p.Q901Q	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	901					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		GACTCCGATCCTGGGGACTCC	0.612000													5	39					0	0	0.000602	0	0
CASP8AP2	9994	broad.mit.edu	37	6	90572225	90572225	+	RNA	SNP	T	T	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:90572225T>A	ENST00000551025.1	+	0	2234							Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2						cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			NS(1)|endometrium(7)|kidney(6)|large_intestine(12)|lung(21)|ovary(2)|urinary_tract(2)	51		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		CGAAAAGACTTAAGTACTGGC	0.423000													6	193					0	0	0.001168	0	0
SLC38A4	55089	broad.mit.edu	37	12	47173410	47173410	+	Missense_Mutation	SNP	A	A	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr12:47173410A>T	ENST00000447411.1	-	9	907	c.701T>A	c.(700-702)gTg>gAg	p.V234E	SLC38A4_ENST00000266579.4_Missense_Mutation_p.V234E	NM_001143824.1	NP_001137296.1	Q969I6	S38A4_HUMAN	solute carrier family 38, member 4	234					cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|skin(1)	21	Lung SC(27;0.192)|Renal(347;0.236)					AACAAAAAACACCATGCAGGT	0.378000													6	87					0	0	0.001168	0	0
OR9A4	130075	broad.mit.edu	37	7	141619422	141619422	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:141619422G>A	ENST00000548136.1	+	1	806	c.747G>A	c.(745-747)gtG>gtA	p.V249V	MGAM_ENST00000497554.1_Intron	NM_001001656.1	NP_001001656.1	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A, member 4	249					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|large_intestine(9)|lung(7)|prostate(1)|skin(2)	22	Melanoma(164;0.0171)					CCTGTGTTGTGATTGGCTACG	0.502000													8	66					0	0	0.003080	0	0
EPHB1	2047	broad.mit.edu	37	3	134873008	134873008	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:134873008C>T	ENST00000398015.3	+	6	1682	c.1312C>T	c.(1312-1314)Ccc>Tcc	p.P438S	EPHB1_ENST00000493838.1_5'UTR	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	438	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						CTCCACCGTTCCCATCATGCA	0.532000													6	212					0	0	0.001984	0	0
LRFN5	145581	broad.mit.edu	37	14	42356630	42356630	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:42356630C>T	ENST00000554171.1	+	5	3234	c.802C>T	c.(802-804)Ctt>Ttt	p.L268F	LRFN5_ENST00000554120.1_Missense_Mutation_p.L268F|LRFN5_ENST00000298119.4_Missense_Mutation_p.L268F			Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	268	LRRCT.					integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TTCTCCTCCACTTTTAACTGG	0.453000										HNSCC(30;0.082)			6	129					0	0	0.001984	0	0
MC5R	4161	broad.mit.edu	37	18	13826253	13826253	+	Silent	SNP	C	C	T	rs141625505		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr18:13826253C>T	ENST00000324750.3	+	1	711	c.489C>T	c.(487-489)atC>atT	p.I163I		NM_005913.2	NP_005904.1	P33032	MC5R_HUMAN	melanocortin 5 receptor	163					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|upper_aerodigestive_tract(1)	41						GGGCCATCATCGCCGGCATCT	0.567000													10	257					0	0	0.008291	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719940	140719940	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr5:140719940G>A	ENST00000394576.2	+	1	1402	c.1402G>A	c.(1402-1404)Gga>Aga	p.G468R	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAACCCCAGAGGAGCCTCTGT	0.557000													5	83					0	0	0.000602	0	0
DSE	29940	broad.mit.edu	37	6	116752271	116752271	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:116752271C>T	ENST00000331677.3	+	5	1269	c.825C>T	c.(823-825)ctC>ctT	p.L275L	DSE_ENST00000452085.3_Silent_p.L275L|DSE_ENST00000359564.2_Silent_p.L275L|DSE_ENST00000537543.1_Silent_p.L294L			Q9UL01	DSE_HUMAN	dermatan sulfate epimerase	275					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		ACATGTTTCTCGTCCAGAGGC	0.478000													4	76					0	0	0.009096	0	0
OR10R2	343406	broad.mit.edu	37	1	158449784	158449784	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:158449784C>T	ENST00000368152.1	+	1	117	c.117C>T	c.(115-117)agC>agT	p.S39S	RP11-144L1.4_ENST00000419738.1_RNA|RP11-144L1.4_ENST00000426251.1_RNA	NM_001004472.1	NP_001004472.1	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R, member 2	39					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(26)|pancreas(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	41	all_hematologic(112;0.0378)					GTTTTTCCAGCCTTGGTGAAA	0.418000													7	97					0	0	0.001984	0	0
RBM41	55285	broad.mit.edu	37	X	106331885	106331885	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:106331885G>A	ENST00000372487.1	-	5	734	c.708C>T	c.(706-708)ctC>ctT	p.L236L	RBM41_ENST00000203616.8_Intron|RBM41_ENST00000372479.3_Silent_p.L236L	NM_001171080.1	NP_001164551.1	Q96IZ5	RBM41_HUMAN	RNA binding motif protein 41	236							nucleotide binding|RNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	13						CCTTGTCCTGGAGTAATGATG	0.493000													3	21					0	0	0.004672	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140725269	140725269	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr5:140725269G>A	ENST00000253812.6	+	1	1669	c.1669G>A	c.(1669-1671)Gac>Aac	p.D557N	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACCAGAACGACAACGCGCC	0.622000													8	175					0	0	0.004482	0	0
RGS6	9628	broad.mit.edu	37	14	72976951	72976951	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:72976951G>A	ENST00000553530.1	+	14	1262	c.1055G>A	c.(1054-1056)cGa>cAa	p.R352Q	RGS6_ENST00000553525.1_Missense_Mutation_p.R352Q|RGS6_ENST00000407322.4_Missense_Mutation_p.R352Q|RGS6_ENST00000404301.2_Missense_Mutation_p.R352Q|RGS6_ENST00000554782.1_Missense_Mutation_p.R213Q|RGS6_ENST00000434263.2_Missense_Mutation_p.R283Q|RGS6_ENST00000402788.2_Missense_Mutation_p.R352Q|RGS6_ENST00000343854.6_Missense_Mutation_p.R315Q|RGS6_ENST00000406236.4_Missense_Mutation_p.R352Q|RGS6_ENST00000355512.6_Missense_Mutation_p.R352Q|RGS6_ENST00000555571.1_Missense_Mutation_p.R352Q|RGS6_ENST00000556437.1_Missense_Mutation_p.R352Q	NM_001204417.1|NM_001204418.1|NM_001204420.1|NM_001204421.1|NM_001204422.1|NM_004296.5	NP_001191346.1|NP_001191347.1|NP_001191349.1|NP_001191350.1|NP_001191351.1|NP_004287.3	P49758	RGS6_HUMAN	regulator of G-protein signaling 6	352	RGS.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		CAGTTTCTACGATTCCTGGAG	0.473000													9	161					0	0	0.006214	0	0
FCRL3	115352	broad.mit.edu	37	1	157665245	157665245	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:157665245C>T	ENST00000368184.3	-	8	1576	c.1285G>A	c.(1285-1287)Gcc>Acc	p.A429T	RP11-367J7.3_ENST00000453692.1_RNA|FCRL3_ENST00000368186.5_Missense_Mutation_p.A429T|FCRL3_ENST00000473231.1_5'UTR	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	429	Ig-like C2-type 5.					integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					CCAGAGGGGGCTGAGCTGTTC	0.582000													6	146					0	0	0.001168	0	0
OR6A2	8590	broad.mit.edu	37	11	6816292	6816292	+	Silent	SNP	G	G	A	rs77689755		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr11:6816292G>A	ENST00000332601.3	-	1	836	c.648C>T	c.(646-648)ctC>ctT	p.L216L		NM_003696.2	NP_003687.2	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A, member 2	216					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(4)|pancreas(1)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	29		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CAGTGACAGAGAGTGGCCCTA	0.502000													5	109					0	0	0.000602	0	0
ACTRT1	139741	broad.mit.edu	37	X	127185107	127185107	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:127185107G>A	ENST00000371124.3	-	1	1275	c.1079C>T	c.(1078-1080)tCg>tTg	p.S360L		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	360						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						GAAGTCTGCCGAGGTGACCCA	0.463000													10	93					0	0	0.010729	0	0
SERPINA4	5267	broad.mit.edu	37	14	95030295	95030295	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:95030295C>T	ENST00000557004.1	+	2	897	c.476C>T	c.(475-477)aCc>aTc	p.T159I	SERPINA5_ENST00000553780.1_Intron|SERPINA4_ENST00000555095.1_Missense_Mutation_p.T159I|SERPINA4_ENST00000298841.5_Missense_Mutation_p.T159I			P29622	KAIN_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	159					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(28)|ovary(3)|skin(1)|urinary_tract(1)	46				COAD - Colon adenocarcinoma(157;0.211)		CTGAATGACACCATGGCCGTC	0.532000													5	92					0	0	0.001984	0	0
C7orf62	219557	broad.mit.edu	37	7	88424246	88424246	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:88424246G>A	ENST00000297203.2	-	2	196	c.11C>T	c.(10-12)tCg>tTg	p.S4L	ZNF804B_ENST00000333190.4_Intron	NM_152706.3	NP_689919.1	Q8TBZ9	CG062_HUMAN	chromosome 7 open reading frame 62	4										NS(1)|breast(1)|endometrium(3)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	30						GTTATGGACCGAAAAGGACAT	0.418000													6	99					0	0	0.001168	0	0
SLC10A3	8273	broad.mit.edu	37	X	153716271	153716271	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:153716271C>T	ENST00000263512.4	-	2	1507	c.1009G>A	c.(1009-1011)Ggc>Agc	p.G337S	SLC10A3_ENST00000369649.4_Missense_Mutation_p.G308S|SLC10A3_ENST00000393587.4_Missense_Mutation_p.G337S|SLC10A3_ENST00000393586.1_Missense_Mutation_p.G392S	NM_019848.3	NP_062822.1	P09131	P3_HUMAN	solute carrier family 10, member 3	337					organic anion transport	integral to membrane	bile acid:sodium symporter activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ATCAGCACGCCCACGGCTATG	0.617000													4	50					0	0	0.000602	0	0
RGS7	6000	broad.mit.edu	37	1	240975259	240975259	+	Silent	SNP	G	G	A	rs114051974	by1000genomes	TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:240975259G>A	ENST00000366565.1	-	14	1422	c.1041C>T	c.(1039-1041)ttC>ttT	p.F347F	RGS7_ENST00000348120.2_Silent_p.F294F|RGS7_ENST00000366564.1_Silent_p.F347F|RGS7_ENST00000446183.2_Silent_p.F263F|RGS7_ENST00000331110.7_Silent_p.F321F|RGS7_ENST00000407727.1_Silent_p.F347F|RGS7_ENST00000366562.4_Silent_p.F347F|RGS7_ENST00000401882.1_Silent_p.F294F|RGS7_ENST00000366563.1_Silent_p.F347F	NM_002924.4	NP_002915.3	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	347	RGS.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(51)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			GAAATTTAAGGAACTGTTCTC	0.418000													4	56					0	0	0.009096	0	0
PKHD1	5314	broad.mit.edu	37	6	51882277	51882277	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:51882277G>A	ENST00000371117.3	-	34	5806	c.5531C>T	c.(5530-5532)tCc>tTc	p.S1844F	PKHD1_ENST00000340994.4_Missense_Mutation_p.S1844F	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1844					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GAGGCATTGGGAACTTTCCTC	0.493000													5	92					0	0	0.000602	0	0
SEL1L2	80343	broad.mit.edu	37	20	13830965	13830965	+	Splice_Site	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr20:13830965C>T	ENST00000284951.5	-	19	1893	c.1818_splice	c.e19-1	p.D607_splice	SEL1L2_ENST00000378072.5_Splice_Site_p.D494_splice|SEL1L2_ENST00000486903.1_5'UTR			Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 (C. elegans)	607						integral to membrane	binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	51						AAGTGAATGTCCTAGAAGGAG	0.438000													4	69					0	0	0.009096	0	0
PROKR2	128674	broad.mit.edu	37	20	5282926	5282926	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr20:5282926G>A	ENST00000546004.1	-	3	1161	c.915C>T	c.(913-915)ttC>ttT	p.F305F	PROKR2_ENST00000217270.3_Silent_p.F305F			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	305						integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						TTTCCTTCACGAACACAGTGG	0.537000										HNSCC(71;0.22)			5	58					0	0	0.000602	0	0
ZNF490	57474	broad.mit.edu	37	19	12691589	12691589	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:12691589G>A	ENST00000311437.6	-	5	1422	c.1300C>T	c.(1300-1302)Cga>Tga	p.R434*	CTD-2192J16.20_ENST00000593682.1_Silent_p.F67F	NM_020714.2	NP_065765.1	Q9ULM2	ZN490_HUMAN	zinc finger protein 490	434					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	18						TCATGGATTCGAAAGTGAGTG	0.413000													4	87					0	0	0.000602	0	0
BRINP2	57795	broad.mit.edu	37	1	177247706	177247706	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:177247706C>T	ENST00000361539.4	+	7	1332	c.1020C>T	c.(1018-1020)ttC>ttT	p.F340F	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		340						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						CAGAAGAGTTCCAGGCCCTGC	0.587000													7	203					0	0	0.004482	0	0
SLC30A8	169026	broad.mit.edu	37	8	118159306	118159306	+	Missense_Mutation	SNP	A	A	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr8:118159306A>T	ENST00000427715.2	+	5	472	c.38A>T	c.(37-39)aAg>aTg	p.K13M	SLC30A8_ENST00000456015.2_Missense_Mutation_p.K62M|SLC30A8_ENST00000519688.1_Missense_Mutation_p.K13M|SLC30A8_ENST00000521243.1_Missense_Mutation_p.K13M	NM_001172813.1|NM_001172815.1	NP_001166284.1|NP_001166286.1	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 (zinc transporter), member 8	62					insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(18)|ovary(2)|pancreas(2)|skin(5)	41	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			CCCACAGAAAAGGGGGCGAAT	0.512000													20	449					0	0	0.008871	0	0
SYNE1	23345	broad.mit.edu	37	6	152949425	152949425	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:152949425G>A	ENST00000367255.5	-	3	643	c.42C>T	c.(40-42)atC>atT	p.I14I	SYNE1_ENST00000367253.4_Silent_p.I14I|SYNE1_ENST00000341594.5_Silent_p.I14I|SYNE1_ENST00000413186.2_Silent_p.I14I|SYNE1_ENST00000423061.1_Silent_p.I14I|SYNE1_ENST00000466159.2_Silent_p.I14I|SYNE1_ENST00000367248.3_Silent_p.I14I|SYNE1_ENST00000448038.1_Silent_p.I14I|SYNE1_ENST00000265368.4_Silent_p.I14I	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	14	Actin-binding.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCACATTGGCGATATCCCGAG	0.502000										HNSCC(10;0.0054)			8	131					0	0	0.006214	0	0
GRK7	131890	broad.mit.edu	37	3	141535611	141535611	+	Missense_Mutation	SNP	C	C	T	rs36004830		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:141535611C>T	ENST00000264952.2	+	4	1518	c.1381C>T	c.(1381-1383)Cgc>Tgc	p.R461C		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	461	AGC-kinase C-terminal.		R -> C (in dbSNP:rs36004830).		visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						CAACTTTCCTCGCCTGGAAGC	0.443000													6	107					0	0	0.001168	0	0
SYT11	23208	broad.mit.edu	37	1	155851155	155851155	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:155851155C>T	ENST00000368324.4	+	4	1405	c.1152C>T	c.(1150-1152)ttC>ttT	p.F384F	SYT11_ENST00000539162.1_Silent_p.F77F	NM_152280.4	NP_689493.3	Q9BT88	SYT11_HUMAN	synaptotagmin XI	384	C2 2.					cell junction|synaptic vesicle membrane	protein binding|transporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;0.000162)			TTATCGACTTCGATCGCACCA	0.537000													16	270					0	0	0.003163	0	0
TAF1L	138474	broad.mit.edu	37	9	32632226	32632226	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr9:32632226C>T	ENST00000242310.4	-	1	3441	c.3352G>A	c.(3352-3354)Gaa>Aaa	p.E1118K		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1118					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TTTCCCATTTCTTCAAAGTCA	0.453000													4	75					0	0	0.009096	0	0
CMYA5	202333	broad.mit.edu	37	5	79031211	79031211	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr5:79031211C>T	ENST00000446378.2	+	2	6654	c.6623C>T	c.(6622-6624)cCa>cTa	p.P2208L		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2208						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CAGCCAAGTCCATCCGTAGAA	0.398000													5	141					0	0	0.000602	0	0
THSD4	79875	broad.mit.edu	37	15	72021016	72021016	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:72021016G>A	ENST00000355327.3	+	9	1620	c.1486G>A	c.(1486-1488)Gag>Aag	p.E496K	THSD4_ENST00000261862.6_Missense_Mutation_p.E496K|THSD4_ENST00000567838.1_3'UTR|THSD4_ENST00000357769.4_Missense_Mutation_p.E136K			Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	496						proteinaceous extracellular matrix	metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						CACTGCCGGAGAGTCCTTTTT	0.483000													8	171					0	0	0.004482	0	0
ZNF287	57336	broad.mit.edu	37	17	16470880	16470880	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:16470880G>A	ENST00000395824.1	-	2	783	c.166C>T	c.(166-168)Cca>Tca	p.P56S	ZNF287_ENST00000395825.3_Missense_Mutation_p.P56S			Q9HBT7	ZN287_HUMAN	zinc finger protein 287	49	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(5)|prostate(1)|urinary_tract(1)	20				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		TCTGGGTATGGAAAATTCCTA	0.458000													5	72					0	0	0.001168	0	0
ANK3	288	broad.mit.edu	37	10	61815462	61815462	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr10:61815462C>T	ENST00000280772.1	-	42	13210	c.13019G>A	c.(13018-13020)aGg>aAg	p.R4340K	ANK3_ENST00000373827.2_Missense_Mutation_p.R1824K|ANK3_ENST00000355288.2_Missense_Mutation_p.R964K|ANK3_ENST00000503366.1_Missense_Mutation_p.R1831K	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	4340					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GAGGCTAAGCCTTGGCTTGCC	0.468000													10	221					0	0	0.010729	0	0
TBX20	57057	broad.mit.edu	37	7	35242110	35242110	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:35242110G>A	ENST00000408931.3	-	8	1802	c.1276C>T	c.(1276-1278)Cag>Tag	p.Q426*		NM_001077653.2|NM_001166220.1	NP_001071121.1|NP_001159692.1	Q9UMR3	TBX20_HUMAN	T-box 20	426						nucleus	DNA binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(9)|prostate(1)|skin(1)|stomach(1)	18						GGCCCCTGCTGAAAATAGTGA	0.517000													3	5					0	0	0.004672	0	0
PRKAA2	5563	broad.mit.edu	37	1	57173265	57173265	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:57173265C>T	ENST00000371244.4	+	9	1604	c.1538C>T	c.(1537-1539)tCt>tTt	p.S513F		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	513					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						CATTCACTTTCTGGCTCTCTC	0.488000													7	121					0	0	0.004482	0	0
ANKS1A	23294	broad.mit.edu	37	6	35048853	35048853	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:35048853C>T	ENST00000360359.3	+	17	2765	c.2627C>T	c.(2626-2628)cCt>cTt	p.P876L	ANKS1A_ENST00000535627.1_Intron	NM_015245.2	NP_056060.2	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1A	876						cytoplasm	protein binding			cervix(2)|endometrium(3)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31						CTGCTGCTGCCTCCAGGGGAC	0.627000													7	47					0	0	0.004482	0	0
ACACA	31	broad.mit.edu	37	17	35601576	35601576	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:35601576G>A	ENST00000353139.5	-	21	3151	c.2670C>T	c.(2668-2670)ttC>ttT	p.F890F	ACACA_ENST00000335166.5_Silent_p.F775F|ACACA_ENST00000360679.3_Silent_p.F795F|ACACA_ENST00000394406.2_Silent_p.F853F	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	853					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	GGACATAATGGAACACTCGAT	0.488000													6	78					0	0	0.001168	0	0
APOBEC3B	9582	broad.mit.edu	37	22	39382370	39382370	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr22:39382370C>T	ENST00000402182.3	+	4	577	c.522C>T	c.(520-522)ttC>ttT	p.F174F	APOBEC3B_ENST00000333467.3_Silent_p.F174F|APOBEC3B_ENST00000407298.3_Silent_p.F174F			Q9UH17	ABC3B_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B	174					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|RNA binding|zinc ion binding			cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	13	Melanoma(58;0.04)					GGTACAAATTCGATGAAAATT	0.478000													6	129					0	0	0.001984	0	0
DGCR8	54487	broad.mit.edu	37	22	20074158	20074158	+	Silent	SNP	C	C	T	rs139146240		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr22:20074158C>T	ENST00000351989.3	+	2	1101	c.672C>T	c.(670-672)atC>atT	p.I224I	DGCR8_ENST00000407755.1_Silent_p.I224I|DGCR8_ENST00000383024.2_Silent_p.I224I	NM_022720.6	NP_073557.3	Q8WYQ5	DGCR8_HUMAN	DGCR8 microprocessor complex subunit	224	Necessary for interaction with NCL.|Necessary for nuclear localization and retention.				primary miRNA processing	cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding			NS(2)|breast(1)|endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	Colorectal(54;0.0993)					CTAAAGCAATCGTTCAGAGAG	0.478000													8	129					0	0	0.003080	0	0
TNNI3K	51086	broad.mit.edu	37	1	74901813	74901813	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:74901813G>A	ENST00000370891.2	+	20	2141	c.2125G>A	c.(2125-2127)Gga>Aga	p.G709R	TNNI3K_ENST00000326637.3_Missense_Mutation_p.G608R|FPGT-TNNI3K_ENST00000557284.1_Missense_Mutation_p.G709R|FPGT-TNNI3K_ENST00000370899.3_Missense_Mutation_p.G709R	NM_001112808.2	NP_001106279.1			TNNI3 interacting kinase											cervix(1)|endometrium(3)|kidney(5)|large_intestine(21)|lung(31)|ovary(4)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	76						GGCAGATTTTGGAGGTGAGAT	0.373000													7	91					0	0	0.004482	0	0
ADAM28	10863	broad.mit.edu	37	8	24157538	24157538	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr8:24157538C>T	ENST00000265769.4	+	2	208	c.98C>T	c.(97-99)cCt>cTt	p.P33L	ADAM28_ENST00000437154.2_Missense_Mutation_p.P33L|ADAM28_ENST00000540823.1_5'UTR|RP11-624C23.1_ENST00000518988.1_RNA|RP11-624C23.1_ENST00000523700.1_RNA|ADAM28_ENST00000397649.3_5'UTR	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	33					proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		GTGGTTTATCCTATAAGACTT	0.368000													4	98					0	0	0.000602	0	0
ALPK1	80216	broad.mit.edu	37	4	113346825	113346825	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr4:113346825C>T	ENST00000458497.1	+	7	819	c.540C>T	c.(538-540)acC>acT	p.T180T	ALPK1_ENST00000177648.9_Silent_p.T180T|ALPK1_ENST00000504176.2_Silent_p.T102T	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	180							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		TTTTAGGTACCTGGCTGTACA	0.388000													5	112					0	0	0.001168	0	0
PPP1CC	5501	broad.mit.edu	37	12	111169596	111169596	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr12:111169596C>T	ENST00000335007.5	-	2	356	c.166G>A	c.(166-168)Gaa>Aaa	p.E56K	PPP1CC_ENST00000550991.1_Missense_Mutation_p.E56K|PPP1CC_ENST00000546933.1_Missense_Mutation_p.E65K|PPP1CC_ENST00000340766.5_Missense_Mutation_p.E56K|PPP1CC_ENST00000551676.1_Missense_Mutation_p.E56K	NM_002710.3	NP_002701.1	P36873	PP1G_HUMAN	protein phosphatase 1, catalytic subunit, gamma isozyme	56					cell division|glycogen metabolic process|mitotic prometaphase|triglyceride catabolic process	cleavage furrow|condensed chromosome kinetochore|cytosol|midbody|MLL5-L complex|nuclear speck|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|protein binding|protein kinase binding|protein serine/threonine phosphatase activity			central_nervous_system(1)|large_intestine(2)|lung(3)	6						AGTGGTGCTTCAAGTTCTAGT	0.398000													4	87					0	0	0.009096	0	0
INPP4B	8821	broad.mit.edu	37	4	143235881	143235881	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr4:143235881G>A	ENST00000513000.1	-	9	840	c.407C>T	c.(406-408)cCc>cTc	p.P136L	INPP4B_ENST00000262992.4_Missense_Mutation_p.P136L|INPP4B_ENST00000308502.4_Missense_Mutation_p.P136L|INPP4B_ENST00000508116.1_Missense_Mutation_p.P136L|INPP4B_ENST00000509777.1_Missense_Mutation_p.P136L	NM_003866.2	NP_003857.2	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II, 105kDa	136	C2.				signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity	p.P136L(1)		breast(3)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(29)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58	all_hematologic(180;0.158)					TTCTGGCGGGGGATCCTTATG	0.448000													6	127					0	0	0.001168	0	0
DOT1L	84444	broad.mit.edu	37	19	2180750	2180750	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:2180750C>T	ENST00000398665.3	+	2	156	c.120C>T	c.(118-120)acC>acT	p.T40T		NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	40						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCATCGAGACCATCCGGTGAG	0.562000													4	44					0	0	0.000602	0	0
QRICH1	54870	broad.mit.edu	37	3	49095126	49095126	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:49095126G>A	ENST00000395443.2	-	3	979	c.507C>T	c.(505-507)atC>atT	p.I169I	QRICH1_ENST00000479449.1_Intron|QRICH1_ENST00000424300.1_Silent_p.I169I|QRICH1_ENST00000357496.2_Silent_p.I169I	NM_198880.1	NP_942581.1	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	169	Gln-rich.									breast(2)|endometrium(5)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		GCTGCACCTGGATCTGAGCTG	0.622000													6	111					0	0	0.001168	0	0
LPAR2	9170	broad.mit.edu	37	19	19738063	19738063	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:19738063C>T	ENST00000542587.1	-	5	933	c.31G>A	c.(31-33)Gag>Aag	p.E11K	LPAR2_ENST00000407877.3_Missense_Mutation_p.E11K|LPAR2_ENST00000586703.1_Missense_Mutation_p.E11K			Q9HBW0	LPAR2_HUMAN	lysophosphatidic acid receptor 2	11					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	cell surface|integral to plasma membrane	LIM domain binding|lipid binding			breast(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	10						CCGATGGTCTCGTTGTAGTAG	0.582000													7	105					0	0	0.004482	0	0
DKK2	27123	broad.mit.edu	37	4	107845819	107845819	+	Missense_Mutation	SNP	G	G	A	rs146683175	by1000genomes	TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr4:107845819G>A	ENST00000285311.3	-	3	1117	c.412C>T	c.(412-414)Cac>Tac	p.H138Y	DKK2_ENST00000513208.1_Missense_Mutation_p.H38Y|DKK2_ENST00000510463.1_Missense_Mutation_p.H92Y	NM_014421.2	NP_055236.1	Q9UBU2	DKK2_HUMAN	dickkopf WNT signaling pathway inhibitor 2	138					multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		GCCGGGATGTGAGGGGTTAAG	0.433000													7	88					0	0	0.004482	0	0
EEF2K	29904	broad.mit.edu	37	16	22269896	22269896	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr16:22269896C>T	ENST00000263026.5	+	10	1585	c.1111C>T	c.(1111-1113)Ccc>Tcc	p.P371S		NM_013302.3	NP_037434.1	O00418	EF2K_HUMAN	eukaryotic elongation factor-2 kinase	371					insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(8)|large_intestine(2)|lung(13)|ovary(1)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(48;0.0223)		GAGCCGGCCACCCCTGCTCCG	0.557000													6	83					0	0	0.001168	0	0
TMEM260	54916	broad.mit.edu	37	14	57070588	57070588	+	Missense_Mutation	SNP	C	C	T	rs149705965	byFrequency	TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:57070588C>T	ENST00000261556.6	+	4	522	c.400C>T	c.(400-402)Cgt>Tgt	p.R134C	TMEM260_ENST00000538838.1_Missense_Mutation_p.R134C|TMEM260_ENST00000536419.1_Intron	NM_017799.3	NP_060269.3			transmembrane protein 260																		TTCATTTTCTCGTCTAACATG	0.438000													5	122					0	0	0.001984	0	0
AHCY	191	broad.mit.edu	37	20	32879290	32879290	+	Missense_Mutation	SNP	A	A	G			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr20:32879290A>G	ENST00000538132.1	-	5	795	c.409T>C	c.(409-411)Tac>Cac	p.Y137H	AHCY_ENST00000468908.1_5'UTR|AHCY_ENST00000217426.2_Missense_Mutation_p.Y165H	NM_001161766.1	NP_001155238.1	P23526	SAHH_HUMAN	adenosylhomocysteinase	165					methylation|xenobiotic metabolic process	cytosol|melanosome	adenosylhomocysteinase activity|protein binding			endometrium(6)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						ATCATCTTGTAGAGGTTGTGG	0.567000													7	122					0	0	0.001984	0	0
NPY4R	5540	broad.mit.edu	37	10	47087170	47087170	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr10:47087170C>T	ENST00000374312.1	+	3	806	c.387C>T	c.(385-387)atC>atT	p.I129I	NPY4R_ENST00000395716.1_Silent_p.I129I	NM_005972.4	NP_005963.3			neuropeptide Y receptor Y4																		CGGTCTCCATCCTCTCGCTCG	0.582000													5	166					0	0	0.001168	0	0
IZUMO1	284359	broad.mit.edu	37	19	49249038	49249038	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:49249038G>A	ENST00000332955.2	-	2	626	c.79C>T	c.(79-81)Ccg>Tcg	p.P27S		NM_182575.2	NP_872381.2	Q8IYV9	IZUM1_HUMAN	izumo sperm-egg fusion 1	27					fusion of sperm to egg plasma membrane	integral to membrane				endometrium(4)|kidney(3)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	17		all_lung(116;0.000156)|Lung NSC(112;0.000251)|all_epithelial(76;0.000761)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		ACGACAGACGGGTCACATATA	0.587000													9	105					0	0	0.006214	0	0
SYNE1	23345	broad.mit.edu	37	6	152708213	152708213	+	Silent	SNP	A	A	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:152708213A>T	ENST00000367255.5	-	54	9082	c.8481T>A	c.(8479-8481)gtT>gtA	p.V2827V	SYNE1_ENST00000341594.5_Silent_p.V2866V|SYNE1_ENST00000423061.1_Silent_p.V2834V|SYNE1_ENST00000448038.1_Silent_p.V2834V|SYNE1_ENST00000265368.4_Silent_p.V2827V	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2827					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TAACCTTGGCAACAGTCATTA	0.348000										HNSCC(10;0.0054)			4	62					0	0	0.009096	0	0
C6	729	broad.mit.edu	37	5	41203303	41203303	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr5:41203303G>A	ENST00000263413.3	-	2	294	c.30C>T	c.(28-30)atC>atT	p.I10I	C6_ENST00000337836.5_Silent_p.I10I	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	10					complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CATTCAGCAGGATGAAGTACA	0.463000													5	99					0	0	0.001168	0	0
MOV10L1	54456	broad.mit.edu	37	22	50555645	50555645	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr22:50555645G>A	ENST00000262794.5	+	9	1402	c.1319G>A	c.(1318-1320)cGa>cAa	p.R440Q	MOV10L1_ENST00000545383.1_Missense_Mutation_p.R440Q|MOV10L1_ENST00000540615.1_Missense_Mutation_p.R420Q|MOV10L1_ENST00000395843.1_5'UTR|MOV10L1_ENST00000395858.3_Missense_Mutation_p.R440Q	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	440					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding	p.R440Q(1)		breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		CTAATTGGGCGATACCTTGAA	0.388000													4	59					0	0	0.000602	0	0
SYT1	6857	broad.mit.edu	37	12	79689912	79689912	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr12:79689912C>T	ENST00000261205.4	+	7	1195	c.538C>T	c.(538-540)Cct>Tct	p.P180S	SYT1_ENST00000457153.2_Missense_Mutation_p.P177S|SYT1_ENST00000393240.3_Missense_Mutation_p.P180S|SYT1_ENST00000552744.1_Missense_Mutation_p.P180S	NM_005639.2	NP_005630.1	P21579	SYT1_HUMAN	synaptotagmin I	180	C2 1.|Phospholipid binding (Probable).				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity	p.P180S(1)		NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|pancreas(2)|skin(6)	25						CACATCTGATCCTTACGTGAA	0.423000													4	66					0	0	0.009096	0	0
EPHA8	2046	broad.mit.edu	37	1	22927885	22927885	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:22927885C>T	ENST00000166244.3	+	16	2894	c.2822C>T	c.(2821-2823)tCc>tTc	p.S941F		NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	941	SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TGGCTGGACTCCATCCGCATG	0.682000													4	87					0	0	0.009096	0	0
OSMR	9180	broad.mit.edu	37	5	38869197	38869197	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr5:38869197C>T	ENST00000274276.3	+	2	453	c.51C>T	c.(49-51)tcC>tcT	p.S17S	OSMR_ENST00000502536.1_Silent_p.S17S	NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	17					cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					CATTGCTGTCCTTGAGGACTT	0.348000													5	77					0	0	0.001168	0	0
ZNF259	8882	broad.mit.edu	37	11	116649743	116649743	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr11:116649743C>T	ENST00000227322.3	-	14	1337	c.1278G>A	c.(1276-1278)atG>atA	p.M426I		NM_003904.3	NP_003895.1	O75312	ZPR1_HUMAN	zinc finger protein 259	426					cell proliferation|signal transduction	cytoplasm|nucleolus				breast(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	9	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.61e-06)|all cancers(92;0.000139)|OV - Ovarian serous cystadenocarcinoma(223;0.153)		GCTCCACCTTCATCTCAGGAT	0.542000													9	419					0	0	0.008291	0	0
GALNT15	117248	broad.mit.edu	37	3	16237390	16237390	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:16237390C>T	ENST00000339732.5	+	2	1166	c.663C>T	c.(661-663)gcC>gcT	p.A221A	GALNT15_ENST00000437509.1_Silent_p.A221A	NM_054110.4	NP_473451.3			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15																		TGCCCAGGGCCTTCCTGAAGG	0.617000													4	38					0	0	0.009096	0	0
SPAG1	6674	broad.mit.edu	37	8	101243516	101243516	+	Splice_Site	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr8:101243516G>A	ENST00000388798.2	+	15	2179	c.1988_splice	c.e15+1	p.R663_splice	SPAG1_ENST00000251809.3_Splice_Site_p.R663_splice	NM_003114.4	NP_003105.2	Q07617	SPAG1_HUMAN	sperm associated antigen 1	663					single fertilization	cytoplasm	GTP binding|hydrolase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)		TATACAAACAGGCAAGTTCTT	0.254000													6	78					0	0	0.001168	0	0
PRDM16	63976	broad.mit.edu	37	1	3328862	3328862	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:3328862G>A	ENST00000378398.3	+	10	2186	c.2104G>A	c.(2104-2106)Gag>Aag	p.E702K	PRDM16_ENST00000511072.1_Missense_Mutation_p.E702K|PRDM16_ENST00000442529.2_Missense_Mutation_p.E701K|PRDM16_ENST00000441472.2_Missense_Mutation_p.E701K|PRDM16_ENST00000514189.1_Missense_Mutation_p.E702K|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000378391.2_Missense_Mutation_p.E701K|PRDM16_ENST00000270722.5_Missense_Mutation_p.E701K			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	701	Interaction with CTBP1 and CTBP2 (By similarity).				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		ATCCATTGCCGAGAAGTACTT	0.622000			T	EVI1	"""MDS, AML"""								6	81					0	0	0.001984	0	0
ZCCHC2	54877	broad.mit.edu	37	18	60241404	60241404	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr18:60241404G>A	ENST00000269499.5	+	13	2508	c.2090G>A	c.(2089-2091)gGa>gAa	p.G697E	ZCCHC2_ENST00000586834.1_Missense_Mutation_p.G376E	NM_017742.4	NP_060212.4	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	697					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25						GCTTCACTAGGAAATGAGAAT	0.423000													11	142					0	0	0.013537	0	0
FLG	2312	broad.mit.edu	37	1	152284513	152284513	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:152284513C>T	ENST00000368799.1	-	3	2884	c.2849G>A	c.(2848-2850)aGt>aAt	p.S950N	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	950	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCACTGTCACTGTCCTGGCT	0.562000									Ichthyosis				8	274					0	0	0.006214	0	0
ZBTB22	9278	broad.mit.edu	37	6	33284485	33284485	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:33284485G>A	ENST00000431845.2	-	2	360	c.209C>T	c.(208-210)gCt>gTt	p.A70V	ZBTB22_ENST00000418724.1_Missense_Mutation_p.A70V	NM_005453.4	NP_005444.4	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	70	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(3)	21						AGCCCGATGAGCCCGGAACTC	0.607000													7	105					0	0	0.003080	0	0
HK2	3099	broad.mit.edu	37	2	75115072	75115072	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:75115072C>T	ENST00000290573.2	+	16	2862	c.2262C>T	c.(2260-2262)gtC>gtT	p.V754V	HK2_ENST00000409174.1_Silent_p.V726V	NM_000189.4	NP_000180.2	P52789	HXK2_HUMAN	hexokinase 2	754	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	43						GTGAGATTGTCCGTAACATTC	0.473000													5	109					0	0	0.001168	0	0
PDYN	5173	broad.mit.edu	37	20	1963712	1963712	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr20:1963712C>T	ENST00000217305.2	-	3	244	c.19G>A	c.(19-21)Gtc>Atc	p.V7I	PDYN_ENST00000539905.1_Missense_Mutation_p.V7I|RP4-684O24.5_ENST00000446562.1_RNA|PDYN_ENST00000540134.1_Missense_Mutation_p.V7I	NM_001190892.1|NM_001190898.2|NM_024411.4	NP_001177821.1|NP_001177827.1|NP_077722.1	P01213	PDYN_HUMAN	prodynorphin	7					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GCAGCCAGGACCAGCCCCTGC	0.552000													5	47					0	0	0.001168	0	0
PDE1A	5136	broad.mit.edu	37	2	183070702	183070702	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:183070702C>T	ENST00000435564.1	-	8	1115	c.915G>A	c.(913-915)atG>atA	p.M305I	PDE1A_ENST00000536095.1_Missense_Mutation_p.M201I|PDE1A_ENST00000346717.4_Missense_Mutation_p.M271I|PDE1A_ENST00000331935.6_Missense_Mutation_p.M305I|PDE1A_ENST00000456212.1_Missense_Mutation_p.M305I|PDE1A_ENST00000410103.1_Missense_Mutation_p.M305I|PDE1A_ENST00000409365.1_Missense_Mutation_p.M289I|PDE1A_ENST00000358139.2_Missense_Mutation_p.M305I|PDE1A_ENST00000351439.5_Missense_Mutation_p.M289I	NM_001258312.1|NM_005019.4	NP_001245241.1|NP_005010.2	P54750	PDE1A_HUMAN	phosphodiesterase 1A, calmodulin-dependent	305	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding	p.M305I(2)		endometrium(5)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(2)	35			OV - Ovarian serous cystadenocarcinoma(117;0.061)			TCAAGATATTCATTTCTTCTT	0.343000													4	23					0	0	0.009096	0	0
TMC5	79838	broad.mit.edu	37	16	19455440	19455440	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr16:19455440C>T	ENST00000396229.2	+	4	1575	c.826C>T	c.(826-828)Cgt>Tgt	p.R276C	TMC5_ENST00000381414.4_Missense_Mutation_p.R276C|TMC5_ENST00000542583.2_Missense_Mutation_p.R276C|TMC5_ENST00000541464.1_Missense_Mutation_p.R276C	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	276						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						GCCCTCATTTCGTCACAGGAG	0.463000													5	106					0	0	0.001168	0	0
MUC17	140453	broad.mit.edu	37	7	100682054	100682054	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:100682054G>A	ENST00000306151.4	+	3	7421	c.7357G>A	c.(7357-7359)Gaa>Aaa	p.E2453K		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2453	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					ACCTCCTAGTGAAGGAACCAC	0.537000													18	364					0	0	0.006122	0	0
TRAV4	28689	broad.mit.edu	37	14	22205027	22205027	+	RNA	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:22205027G>A	ENST00000390426.2	+	0	158																											GGACTCATATGAAGGACAAGA	0.443000													7	81					0	0	0.003080	0	0
GIMAP5	55340	broad.mit.edu	37	7	150439461	150439461	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:150439461C>T	ENST00000358647.3	+	3	601	c.234C>T	c.(232-234)gtC>gtT	p.V78V	GIMAP5_ENST00000479556.1_3'UTR	NM_018384.4	NP_060854.2			GTPase, IMAP family member 5											central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|urinary_tract(2)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGAGGAAAGTCCTGGTGGTTG	0.592000													5	68					0	0	0.001168	0	0
GALR3	8484	broad.mit.edu	37	22	38221146	38221146	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr22:38221146G>A	ENST00000249041.2	+	2	801	c.776G>A	c.(775-777)tGg>tAg	p.W259*		NM_003614.1	NP_003605.1	O60755	GALR3_HUMAN	galanin receptor 3	259					feeding behavior|learning or memory|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity			endometrium(1)|liver(2)|lung(1)	4	Melanoma(58;0.045)					CTGTGCTTCTGGTACGGCCGC	0.736000													4	20					0	0	0.009096	0	0
GH1	2688	broad.mit.edu	37	17	61995475	61995475	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:61995475C>T	ENST00000323322.5	-	3	235	c.193G>A	c.(193-195)Gaa>Aaa	p.E65K	GH1_ENST00000458650.2_Intron|GH1_ENST00000342364.4_Intron|CSHL1_ENST00000392824.4_Intron|GH1_ENST00000351388.4_Intron	NM_000515.3	NP_000506.2	P01241	SOMA_HUMAN	growth hormone 1	65					glucose transport|growth hormone receptor signaling pathway|JAK-STAT cascade|positive regulation of activation of JAK2 kinase activity|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of multicellular organism growth|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|response to estradiol stimulus	extracellular space	growth factor activity|growth hormone receptor binding|hormone activity|metal ion binding|prolactin receptor binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)	19						TACTTCTGTTCCTTTGGGATA	0.512000													7	173					0	0	0.003080	0	0
CHMP4B	128866	broad.mit.edu	37	20	32439967	32439967	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr20:32439967C>T	ENST00000217402.2	+	4	733	c.568C>T	c.(568-570)Cct>Tct	p.P190S		NM_176812.4	NP_789782.1	Q9H444	CHM4B_HUMAN	charged multivesicular body protein 4B	190					cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	13						CGAAACAGTCCCTCTACCAAA	0.473000													4	143					0	0	0.000602	0	0
MEGF11	84465	broad.mit.edu	37	15	66262970	66262970	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:66262970C>T	ENST00000409699.2	-	8	992	c.820G>A	c.(820-822)Gat>Aat	p.D274N	MEGF11_ENST00000360698.4_Missense_Mutation_p.D274N|MEGF11_ENST00000288745.3_Missense_Mutation_p.D199N|MEGF11_ENST00000395625.2_Missense_Mutation_p.D199N|MEGF11_ENST00000395614.1_5'UTR|MEGF11_ENST00000422354.1_Missense_Mutation_p.D274N			A6BM72	MEG11_HUMAN	multiple EGF-like-domains 11	274	EGF-like 5.					basolateral plasma membrane|integral to membrane				breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	19						CAAGGACAATCCTGGCTGCAG	0.552000													3	31					0	0	0.004672	0	0
DNAH5	1767	broad.mit.edu	37	5	13928224	13928224	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr5:13928224C>T	ENST00000265104.4	-	3	360	c.256G>A	c.(256-258)Gat>Aat	p.D86N		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	86	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TCCTCCACATCTTGATAGTAA	0.363000									Kartagener syndrome				4	51					0	0	0.000602	0	0
SLC10A3	8273	broad.mit.edu	37	X	153716270	153716270	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:153716270C>T	ENST00000263512.4	-	2	1508	c.1010G>A	c.(1009-1011)gGc>gAc	p.G337D	SLC10A3_ENST00000369649.4_Missense_Mutation_p.G308D|SLC10A3_ENST00000393587.4_Missense_Mutation_p.G337D|SLC10A3_ENST00000393586.1_Missense_Mutation_p.G392D	NM_019848.3	NP_062822.1	P09131	P3_HUMAN	solute carrier family 10, member 3	337					organic anion transport	integral to membrane	bile acid:sodium symporter activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GATCAGCACGCCCACGGCTAT	0.617000													4	48					0	0	0.000602	0	0
USH1C	10083	broad.mit.edu	37	11	17531348	17531348	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr11:17531348G>A	ENST00000005226.7	-	18	1567	c.1568C>T	c.(1567-1569)tCt>tTt	p.S523F	USH1C_ENST00000529563.1_Intron|USH1C_ENST00000527720.1_Intron|USH1C_ENST00000318024.4_Intron|USH1C_ENST00000527020.1_Intron	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	0	PDZ 3.				equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						GGCCAGGGGAGACACAGAAGG	0.582000													5	77					0	0	0.001168	0	0
LRP2	4036	broad.mit.edu	37	2	170063502	170063502	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:170063502C>T	ENST00000263816.3	-	39	7013	c.6728G>A	c.(6727-6729)cGa>cAa	p.R2243Q		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2243					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding	p.R2243Q(1)		biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GCCATCACTTCGGTCCACTGC	0.463000													5	138					0	0	0.001168	0	0
LPHN2	23266	broad.mit.edu	37	1	82447545	82447545	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:82447545C>T	ENST00000370728.1	+	21	3800	c.3155C>T	c.(3154-3156)tCc>tTc	p.S1052F	LPHN2_ENST00000319517.6_Missense_Mutation_p.S1039F|LPHN2_ENST00000335786.5_Missense_Mutation_p.S1052F|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000370730.1_Missense_Mutation_p.S1052F|LPHN2_ENST00000359929.3_Missense_Mutation_p.S1039F|LPHN2_ENST00000370721.1_Missense_Mutation_p.S977F|LPHN2_ENST00000394879.1_Missense_Mutation_p.S1054F|LPHN2_ENST00000370723.1_Missense_Mutation_p.S1054F|LPHN2_ENST00000370725.1_Missense_Mutation_p.S1067F|LPHN2_ENST00000370715.1_Missense_Mutation_p.S1039F|LPHN2_ENST00000370727.1_Missense_Mutation_p.S1067F|LPHN2_ENST00000370713.1_Missense_Mutation_p.S1039F|LPHN2_ENST00000271029.4_Missense_Mutation_p.S1067F|LPHN2_ENST00000370717.2_Missense_Mutation_p.S1067F			O95490	LPHN2_HUMAN	latrophilin 2	1052					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding	p.S1039F(1)|p.S1067F(1)		NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		CTCACCTGGTCCTTTGGGTTG	0.393000													10	189					0	0	0.006214	0	0
CCDC28A	25901	broad.mit.edu	37	6	139094833	139094833	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:139094833G>A	ENST00000332797.6	+	1	177	c.22G>A	c.(22-24)Gcg>Acg	p.A8T		NM_015439.2	NP_056254.1	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	8										autonomic_ganglia(1)|large_intestine(3)|lung(8)|ovary(1)	13				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		GGAGCCAAGAGCGACACTGGG	0.597000													5	128					0	0	0.001168	0	0
KIAA0195	9772	broad.mit.edu	37	17	73491074	73491074	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:73491074G>A	ENST00000314256.7	+	20	3081	c.2687G>A	c.(2686-2688)aGc>aAc	p.S896N	KIAA0195_ENST00000579208.1_Missense_Mutation_p.S547N|KIAA0195_ENST00000375248.5_Missense_Mutation_p.S906N	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	896					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCCCCCTCCAGCCCCAGCCAC	0.622000													8	101					0	0	0.003080	0	0
GPR34	2857	broad.mit.edu	37	X	41555476	41555476	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:41555476G>A	ENST00000378142.4	+	3	874	c.590G>A	c.(589-591)gGa>gAa	p.G197E	CASK_ENST00000378166.4_Intron|CASK_ENST00000378163.1_Intron|CASK_ENST00000361962.4_Intron|CASK_ENST00000442742.2_Intron|GPR34_ENST00000378138.5_Missense_Mutation_p.G197E|CASK_ENST00000378154.1_Intron|CASK_ENST00000421587.2_Intron|CASK_ENST00000318588.9_Intron|CASK_ENST00000378158.1_Intron	NM_001097579.1|NM_005300.3	NP_001091048.1|NP_005291.1	Q9UPC5	GPR34_HUMAN	G protein-coupled receptor 34	197						integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			breast(1)|endometrium(1)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	14						CTTAAGAAAGGAGGGCATAAT	0.343000													3	19					0	0	0.004672	0	0
GUCY2F	2986	broad.mit.edu	37	X	108684589	108684589	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:108684589C>T	ENST00000218006.2	-	7	1983	c.1692G>A	c.(1690-1692)gcG>gcA	p.A564A		NM_001522.2	NP_001513.2	P51841	GUC2F_HUMAN	guanylate cyclase 2F, retinal	564	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity	p.A564A(1)		breast(3)|central_nervous_system(2)|endometrium(5)|kidney(6)|large_intestine(14)|lung(33)|prostate(3)|skin(1)	67						CCTCATAAATCGCTATGTTGG	0.403000													6	90					0	0	0.001168	0	0
RASSF2	9770	broad.mit.edu	37	20	4776507	4776507	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr20:4776507G>A	ENST00000379400.3	-	5	436	c.241C>T	c.(241-243)Cca>Tca	p.P81S	RASSF2_ENST00000379376.2_Missense_Mutation_p.P81S	NM_014737.2	NP_055552.1	P50749	RASF2_HUMAN	Ras association (RalGDS/AF-6) domain family member 2	81					cell cycle|signal transduction	nucleus	protein binding	p.P81A(1)		endometrium(3)|kidney(2)|large_intestine(8)|lung(12)|ovary(3)|pancreas(2)|prostate(2)|skin(2)	34						GAGGAGGATGGAGGGGGTCGA	0.612000													4	91					0	0	0.000602	0	0
ZNF488	118738	broad.mit.edu	37	10	48371419	48371419	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr10:48371419C>T	ENST00000395702.2	+	2	1114	c.887C>T	c.(886-888)tCc>tTc	p.S296F	ZNF488_ENST00000494156.1_3'UTR|ZNF488_ENST00000586537.1_Missense_Mutation_p.S189F			Q96MN9	ZN488_HUMAN	zinc finger protein 488	296					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|ovary(2)	14						CACATGCGATCCCACCACAAA	0.607000													4	86					0	0	0.009096	0	0
ARID5B	84159	broad.mit.edu	37	10	63851616	63851616	+	Missense_Mutation	SNP	C	C	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr10:63851616C>A	ENST00000279873.7	+	10	2804	c.2394C>A	c.(2392-2394)gaC>gaA	p.D798E	ARID5B_ENST00000309334.5_Missense_Mutation_p.D555E	NM_032199.2	NP_115575.1	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	798					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			NS(1)|breast(2)|endometrium(13)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	Prostate(12;0.016)|all_hematologic(501;0.215)					CCCTTGCTGACTCCTACGTCC	0.498000													6	133					2.0095e-06	2.22138e-06	0.001984	1	0
OR10K1	391109	broad.mit.edu	37	1	158435856	158435856	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:158435856C>T	ENST00000289451.2	+	1	585	c.505C>T	c.(505-507)Cac>Tac	p.H169Y		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	169					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					TCTGCCCTTCCACTCCTCCAA	0.537000													6	205					0	0	0.004482	0	0
OR10H4	126541	broad.mit.edu	37	19	16059904	16059904	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:16059904C>T	ENST00000322107.1	+	1	87	c.87C>T	c.(85-87)ttC>ttT	p.F29F		NM_001004465.1	NP_001004465.1	Q8NGA5	O10H4_HUMAN	olfactory receptor, family 10, subfamily H, member 4	29					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	17						CCATCTTGTTCCTGCTGTACC	0.483000													9	187					0	0	0.004482	0	0
POP1	10940	broad.mit.edu	37	8	99146184	99146184	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr8:99146184C>T	ENST00000401707.2	+	6	824	c.743C>T	c.(742-744)tCc>tTc	p.S248F	POP1_ENST00000349693.3_Missense_Mutation_p.S248F	NM_001145860.1|NM_001145861.1	NP_001139332.1|NP_001139333.1	Q99575	POP1_HUMAN	processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)	248					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			autonomic_ganglia(1)|breast(3)|endometrium(4)|large_intestine(9)|lung(15)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			CAGGATTTATCCTATTACTGT	0.388000													6	86					0	0	0.001984	0	0
SAMD4A	23034	broad.mit.edu	37	14	55236885	55236885	+	Missense_Mutation	SNP	C	C	T	rs146324552		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:55236885C>T	ENST00000251091.5	+	7	1701	c.1396C>T	c.(1396-1398)Cgg>Tgg	p.R466W	SAMD4A_ENST00000392067.3_Missense_Mutation_p.R554W|SAMD4A_ENST00000357634.3_Missense_Mutation_p.R553W|SAMD4A_ENST00000555192.1_Missense_Mutation_p.R145W|SAMD4A_ENST00000554335.1_Missense_Mutation_p.R554W	NM_001161576.2	NP_001155048.2	Q9UPU9	SMAG1_HUMAN	sterile alpha motif domain containing 4A	554					positive regulation of translation	cell junction|cytoplasm|dendrite|synapse|synaptosome	translation repressor activity	p.R553W(1)		breast(2)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|prostate(1)|skin(1)	29						GAAGCTCTTTCGGTCTTTCCC	0.423000													6	91					0	0	0.001168	0	0
CNBD2	140894	broad.mit.edu	37	20	34563906	34563906	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr20:34563906G>A	ENST00000373973.3	+	3	398	c.225G>A	c.(223-225)atG>atA	p.M75I	CNBD2_ENST00000538900.1_Missense_Mutation_p.M75I|CNBD2_ENST00000349339.1_Missense_Mutation_p.M75I					cyclic nucleotide binding domain containing 2																		TTGATACCATGGACTTCATTG	0.483000													6	85					0	0	0.001984	0	0
CHRNB4	1143	broad.mit.edu	37	15	78922021	78922021	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:78922021C>T	ENST00000261751.3	-	5	737	c.626G>A	c.(625-627)aGa>aAa	p.R209K	CHRNB4_ENST00000412074.2_Intron	NM_000750.3	NP_000741.1	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4 (neuronal)	209					regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(7)|kidney(1)|lung(13)|prostate(1)	22						CACTGTCCTTCTCCCTGGGAG	0.542000													5	117					0	0	0.001168	0	0
LAMA2	3908	broad.mit.edu	37	6	129636797	129636797	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:129636797G>A	ENST00000421865.2	+	25	3781	c.3732G>A	c.(3730-3732)aaG>aaA	p.K1244K		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1244	Laminin IV type A 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TTGAAGGAAAGAAGGTAAGCA	0.343000													4	54					0	0	0.009096	0	0
KLHL14	57565	broad.mit.edu	37	18	30322008	30322008	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr18:30322008G>A	ENST00000359358.4	-	3	1390	c.952C>T	c.(952-954)Cgc>Tgc	p.R318C	KLHL14_ENST00000358095.4_Missense_Mutation_p.R318C	NM_020805.1	NP_065856.1	Q9P2G3	KLH14_HUMAN	kelch-like family member 14	318						cytosol|endoplasmic reticulum membrane				breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2)	31						TTGTTAGAGCGAATTCTTCAC	0.428000													4	75					0	0	0.000602	0	0
RIMBP2	23504	broad.mit.edu	37	12	130883694	130883694	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr12:130883694G>A	ENST00000261655.4	-	19	3308	c.3145C>T	c.(3145-3147)Cat>Tat	p.H1049Y		NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	1049						cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GGTGTGAAATGAACACTCTTC	0.333000													5	107					0	0	0.001168	0	0
ERC2	26059	broad.mit.edu	37	3	56468411	56468411	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:56468411C>T	ENST00000288221.6	-	2	880	c.625G>A	c.(625-627)Gag>Aag	p.E209K		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	209						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		CTCATCTGCTCCTTGAGGACA	0.458000													4	78					0	0	0.009096	0	0
CYTIP	9595	broad.mit.edu	37	2	158272435	158272435	+	Silent	SNP	C	C	T	rs141179083	byFrequency	TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:158272435C>T	ENST00000264192.3	-	8	955	c.834G>A	c.(832-834)acG>acA	p.T278T	CYTIP_ENST00000540637.1_Silent_p.T172T	NM_004288.4	NP_004279.3	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	278	Ser-rich.			T -> Q (in Ref. 5; AAA16575).	regulation of cell adhesion	cell cortex|early endosome	protein binding			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	15						CATCTGTACTCGTCTGCCGAC	0.542000													6	72					0	0	0.001984	0	0
GIMAP6	474344	broad.mit.edu	37	7	150327203	150327203	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:150327203G>A	ENST00000328902.5	-	2	244	c.28C>T	c.(28-30)Ccc>Tcc	p.P10S	GIMAP6_ENST00000493969.1_Missense_Mutation_p.P10S	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	10							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTCTCCTGGGGAATTTGTTCA	0.428000													7	102					0	0	0.001984	0	0
MUC16	94025	broad.mit.edu	37	19	9068069	9068069	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:9068069G>A	ENST00000397910.4	-	3	19580	c.19377C>T	c.(19375-19377)acC>acT	p.T6459T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6461	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCCAGGTAAGGGTACCCTGTG	0.483000													15	194					0	0	0.004990	0	0
HLA-DMA	3108	broad.mit.edu	37	6	32917102	32917102	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:32917102C>T	ENST00000374843.4	-	4	812	c.727G>A	c.(727-729)Ggc>Agc	p.G243S	HLA-DMA_ENST00000395305.3_Missense_Mutation_p.G148S|HLA-DMA_ENST00000464392.1_5'UTR|HLA-DMA_ENST00000395303.3_Missense_Mutation_p.G209S|XXbac-BPG181M17.5_ENST00000429234.1_Intron	NM_006120.3	NP_006111.2	Q31604	Q31604_HUMAN	major histocompatibility complex, class II, DM alpha	243						integral to membrane|MHC class II protein complex				kidney(1)|large_intestine(2)|lung(8)	11						ACGATGATGCCCAGCACACCC	0.587000													4	44					0	0	0.009096	0	0
GRM2	2912	broad.mit.edu	37	3	51747031	51747031	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:51747031C>T	ENST00000395052.3	+	3	1227	c.993C>T	c.(991-993)ttC>ttT	p.F331F	GRM2_ENST00000442933.2_Silent_p.F331F|GRM2_ENST00000475478.1_Intron	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	331					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	CCTCCTACTTCCAGAGCCTGG	0.632000													4	43					0	0	0.009096	0	0
OR2T10	127069	broad.mit.edu	37	1	248756631	248756631	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:248756631C>T	ENST00000330500.2	-	1	469	c.439G>A	c.(439-441)Ggc>Agc	p.G147S		NM_001004693.1	NP_001004693.1	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T, member 10	147					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(17)|skin(3)|upper_aerodigestive_tract(1)	26	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AACCAGCAGCCTGATGCCAGG	0.547000													4	94					0	0	0.009096	0	0
EIF6	3692	broad.mit.edu	37	20	33872077	33872077	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr20:33872077G>A	ENST00000374443.3	-	2	263	c.214C>T	c.(214-216)Cat>Tat	p.H72Y	EIF6_ENST00000462894.1_Intron|EIF6_ENST00000374436.3_Intron|EIF6_ENST00000374450.3_Intron	NM_181466.2	NP_852131.1	P56537	IF6_HUMAN	eukaryotic translation initiation factor 6	71					mature ribosome assembly	cytoplasm|nucleolus	protein binding|ribosome binding|translation initiation factor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|pancreas(1)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GTAGGGACATGGACTCGGTGG	0.697000													5	104					0	0	0.000602	0	0
OR51F2	119694	broad.mit.edu	37	11	4843090	4843090	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr11:4843090G>A	ENST00000322110.5	+	1	540	c.475G>A	c.(475-477)Ggg>Agg	p.G159R	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004753.1	NP_001004753.1	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F, member 2	159					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(4)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGCCAAGATTGGGATGAGCAT	0.463000													11	177					0	0	0.013537	0	0
DSE	29940	broad.mit.edu	37	6	116747888	116747888	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:116747888G>A	ENST00000331677.3	+	4	1012	c.568G>A	c.(568-570)Gaa>Aaa	p.E190K	DSE_ENST00000452085.3_Missense_Mutation_p.E190K|DSE_ENST00000359564.2_Missense_Mutation_p.E190K|DSE_ENST00000606265.1_3'UTR|DSE_ENST00000537543.1_Missense_Mutation_p.E209K			Q9UL01	DSE_HUMAN	dermatan sulfate epimerase	190					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		GTATATGTATGAAACTTCATA	0.448000													5	36					0	0	0.000602	0	0
RYR3	6263	broad.mit.edu	37	15	33855117	33855117	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:33855117C>T	ENST00000389232.4	+	11	1122	c.1052C>T	c.(1051-1053)tCt>tTt	p.S351F	RYR3_ENST00000415757.3_Missense_Mutation_p.S351F	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	351	MIR 5.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TATGGAGATTCTGTCTGCTTT	0.448000													4	74					0	0	0.009096	0	0
PYGO1	26108	broad.mit.edu	37	15	55838810	55838810	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:55838810G>A	ENST00000302000.6	-	3	765	c.671C>T	c.(670-672)cCt>cTt	p.P224L	PYGO1_ENST00000563719.1_Missense_Mutation_p.P224L	NM_015617.1	NP_056432.1	Q9Y3Y4	PYGO1_HUMAN	pygopus family PHD finger 1	224	Asn-rich.				Wnt receptor signaling pathway	nucleus	zinc ion binding			endometrium(4)|kidney(2)|large_intestine(6)|lung(6)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	27				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		GTTTGGGGGAGGAATAAAAGA	0.378000													5	89					0	0	0.000602	0	0
TBC1D3P1-DHX40P1	653645	broad.mit.edu	37	17	58089064	58089064	+	RNA	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:58089064C>T	ENST00000407042.3	-	0	779																											CAGAGCCTTCCCCCAAGATGT	0.617000													4	116					0	0	0.009096	0	0
STK31	56164	broad.mit.edu	37	7	23808714	23808714	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:23808714G>A	ENST00000354639.3	+	12	1912	c.1448G>A	c.(1447-1449)aGa>aAa	p.R483K	STK31_ENST00000355870.3_Missense_Mutation_p.R506K|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000428484.1_Missense_Mutation_p.R483K|STK31_ENST00000433467.2_Missense_Mutation_p.R506K	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	506							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TGTGATAAAAGAGAGGAGTTC	0.403000													6	83					0	0	0.001984	0	0
C5AR2	27202	broad.mit.edu	37	19	47844136	47844136	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:47844136C>T	ENST00000595464.1	+	2	298	c.80C>T	c.(79-81)gCc>gTc	p.A27V	C5AR2_ENST00000257267.2_Missense_Mutation_p.A27V|C5AR2_ENST00000600626.1_Missense_Mutation_p.A27V	NM_001271749.1	NP_001258678.1			complement component 5a receptor 2																		CTGGATGGCGCCTGCCTGGCC	0.662000													5	106					0	0	0.001168	0	0
C1orf111	284680	broad.mit.edu	37	1	162344380	162344380	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:162344380C>T	ENST00000367935.4	-	3	323	c.244G>A	c.(244-246)Gga>Aga	p.G82R	RP11-565P22.6_ENST00000431696.1_Intron|C1orf111_ENST00000493255.1_5'UTR	NM_182581.3	NP_872387.2	Q5T0L3	CA111_HUMAN	chromosome 1 open reading frame 111	82								p.G82R(1)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	11	all_hematologic(112;0.15)		BRCA - Breast invasive adenocarcinoma(70;0.0938)			AGCTTCTCTCCGTGCTGGGTA	0.572000													5	121					0	0	0.000602	0	0
AHCY	191	broad.mit.edu	37	20	32879291	32879291	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr20:32879291G>A	ENST00000538132.1	-	5	794	c.408C>T	c.(406-408)ctC>ctT	p.L136L	AHCY_ENST00000468908.1_5'UTR|AHCY_ENST00000217426.2_Silent_p.L164L	NM_001161766.1	NP_001155238.1	P23526	SAHH_HUMAN	adenosylhomocysteinase	164					methylation|xenobiotic metabolic process	cytosol|melanosome	adenosylhomocysteinase activity|protein binding			endometrium(6)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						TCATCTTGTAGAGGTTGTGGA	0.567000													7	122					0	0	0.001984	0	0
ADAMTS4	9507	broad.mit.edu	37	1	161166530	161166530	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:161166530G>A	ENST00000367996.4	-	2	1202	c.774C>T	c.(772-774)atC>atT	p.I258I	ADAMTS4_ENST00000367995.3_Silent_p.I258I	NM_005099.4	NP_005090.3	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 4	258	Peptidase M12B.				proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(20)|ovary(4)|prostate(3)|skin(1)|urinary_tract(1)	43	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CAGGATTGCGGATGCTTGGGT	0.627000													5	130					0	0	0.000602	0	0
ARID1B	57492	broad.mit.edu	37	6	157522413	157522413	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:157522413C>T	ENST00000346085.5	+	18	4686	c.4685C>T	c.(4684-4686)tCc>tTc	p.S1562F	ARID1B_ENST00000367148.1_Missense_Mutation_p.S1602F|ARID1B_ENST00000275248.4_Missense_Mutation_p.S1544F|ARID1B_ENST00000350026.5_Missense_Mutation_p.S1549F	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1549	Pro-rich.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		TTCCAGCGCTCCCTGGAGAAC	0.617000													5	121					0	0	0.000602	0	0
H2AFY2	55506	broad.mit.edu	37	10	71835480	71835480	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr10:71835480C>T	ENST00000373255.4	+	2	330	c.66C>T	c.(64-66)atC>atT	p.I22I		NM_018649.2	NP_061119.1	Q9P0M6	H2AW_HUMAN	H2A histone family, member Y2	22	Histone H2A.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(4)|skin(1)	15						CAGGTGTCATCTTTCCAGTGG	0.552000													7	58					0	0	0.003080	0	0
SCN1A	6323	broad.mit.edu	37	2	166901655	166901655	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:166901655G>A	ENST00000423058.2	-	10	1577	c.1560C>T	c.(1558-1560)ttC>ttT	p.F520F	SCN1A_ENST00000303395.4_Silent_p.F520F|AC010127.3_ENST00000595268.1_RNA|AC010127.3_ENST00000599041.1_RNA|SCN1A_ENST00000375405.3_Silent_p.F520F|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Silent_p.F520F	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	520						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CAGATTTTTGGAATTCATCCT	0.438000													6	179					0	0	0.003080	0	0
F7	2155	broad.mit.edu	37	13	113770093	113770093	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr13:113770093G>A	ENST00000375581.3	+	6	585	c.550G>A	c.(550-552)Ggg>Agg	p.G184R	F7_ENST00000346342.3_Missense_Mutation_p.G162R|F7_ENST00000541084.1_Missense_Mutation_p.G115R	NM_000131.4	NP_000122.1	P08709	FA7_HUMAN	coagulation factor VII (serum prothrombin conversion accelerator)	184	EGF-like 2.				anti-apoptosis|blood coagulation, extrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of leukocyte chemotaxis|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|glycoprotein binding|serine-type endopeptidase activity			large_intestine(4)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0364)|all_epithelial(44;0.0393)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0737)|Epithelial(84;0.213)|BRCA - Breast invasive adenocarcinoma(86;0.218)		Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Menadione(DB00170)	GCTGGCAGACGGGGTGTCCTG	0.597000													3	31					0	0	0.009096	0	0
NOTCH2	4853	broad.mit.edu	37	1	120469125	120469125	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:120469125G>A	ENST00000256646.2	-	24	4221	c.4002C>T	c.(4000-4002)ccC>ccT	p.P1334P		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	1334	EGF-like 34.				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CACTTACCGGGGGACAACGGC	0.488000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				7	235					0	0	0.001984	0	0
GSN	2934	broad.mit.edu	37	9	124074597	124074597	+	Translation_Start_Site	SNP	C	C	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr9:124074597C>A	ENST00000373807.1	+	0	849				GSN_ENST00000545652.1_Intron|GSN_ENST00000373823.3_Intron|GSN_ENST00000485767.1_3'UTR|GSN_ENST00000341272.2_Intron|GSN_ENST00000394353.2_Intron|GSN_ENST00000412819.1_Intron|GSN_ENST00000373818.4_Intron|GSN_ENST00000436847.1_Intron|GSN_ENST00000449733.1_Intron|GSN_ENST00000373808.2_Intron			P06396	GELS_HUMAN	gelsolin						actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)	21						GCACTGACTTCCTGGGTCTCT	0.597000													5	126					0.000602214	0.000658989	0.000602	1	0
MOXD1	26002	broad.mit.edu	37	6	132649188	132649188	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:132649188G>A	ENST00000367963.3	-	6	1028	c.910C>T	c.(910-912)Cta>Tta	p.L304L	MOXD1_ENST00000336749.3_Silent_p.L236L	NM_015529.2	NP_056344.2	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1	304					catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(3)|skin(1)	37	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		TGGACTTCTAGGAGCACATAA	0.353000													4	95					0	0	0.009096	0	0
FBXW10	10517	broad.mit.edu	37	17	18673392	18673392	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:18673392G>A	ENST00000308799.4	+	10	2306	c.2087G>A	c.(2086-2088)gGc>gAc	p.G696D	FBXW10_ENST00000395667.1_Missense_Mutation_p.G667D|FBXW10_ENST00000573605.1_Intron|FBXW10_ENST00000301938.4_Intron|FBXW10_ENST00000395665.4_Missense_Mutation_p.G667D			Q5XX13	FBW10_HUMAN	F-box and WD repeat domain containing 10	667										NS(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42						TTTATTCAGGGCAACAGGTGG	0.463000													6	269					0	0	0.004482	0	0
ZAN	7455	broad.mit.edu	37	7	100344181	100344181	+	RNA	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:100344181G>A	ENST00000542585.1	+	0	935				ZAN_ENST00000348028.3_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546292.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CATGCTCCTGGACCCCAAGAA	0.587000													5	58					0	0	0.000602	0	0
FILIP1	27145	broad.mit.edu	37	6	76023417	76023417	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:76023417G>A	ENST00000393004.2	-	5	2352	c.2131C>T	c.(2131-2133)Cgg>Tgg	p.R711W	FILIP1_ENST00000237172.7_Missense_Mutation_p.R711W|FILIP1_ENST00000370020.1_Missense_Mutation_p.R612W|FILIP1_ENST00000498523.1_5'UTR			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	711								p.R711W(1)		breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						TCTTCCAACCGAAATCTGTGT	0.413000													9	178					0	0	0.006214	0	0
ATP9A	10079	broad.mit.edu	37	20	50342430	50342430	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr20:50342430G>A	ENST00000338821.5	-	3	519	c.255C>T	c.(253-255)ttC>ttT	p.F85F	ATP9A_ENST00000402822.1_Silent_p.F85F|ATP9A_ENST00000311637.5_Silent_p.F70F|ATP9A_ENST00000477492.1_5'UTR	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	85					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						CAAGAAGTAAGAAATAGAGGT	0.438000													6	61					0	0	0.001984	0	0
PHF12	57649	broad.mit.edu	37	17	27254014	27254014	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:27254014G>A	ENST00000577226.1	-	3	662	c.316C>T	c.(316-318)Cga>Tga	p.R106*	PHF12_ENST00000332830.4_Nonsense_Mutation_p.R106*|PHF12_ENST00000268756.3_Nonsense_Mutation_p.R106*|RP11-20B24.5_ENST00000580782.1_RNA|RP11-20B24.5_ENST00000582631.1_RNA			Q96QT6	PHF12_HUMAN	PHD finger protein 12	106	Interaction with SIN3A.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			ATTACCTTTCGGCGAACAGTG	0.493000													4	75					0	0	0.009096	0	0
FN1	2335	broad.mit.edu	37	2	216271880	216271880	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:216271880G>A	ENST00000354785.4	-	18	3052	c.2683C>T	c.(2683-2685)Caa>Taa	p.Q895*	FN1_ENST00000323926.6_Nonsense_Mutation_p.Q895*|FN1_ENST00000359671.1_Nonsense_Mutation_p.Q895*|FN1_ENST00000446046.1_Nonsense_Mutation_p.Q895*|FN1_ENST00000443816.1_Nonsense_Mutation_p.Q895*|FN1_ENST00000432072.2_Nonsense_Mutation_p.Q895*|FN1_ENST00000421182.1_Nonsense_Mutation_p.Q895*|FN1_ENST00000357867.4_Nonsense_Mutation_p.Q895*|FN1_ENST00000357009.2_Nonsense_Mutation_p.Q895*|FN1_ENST00000356005.4_Nonsense_Mutation_p.Q895*|FN1_ENST00000346544.3_Nonsense_Mutation_p.Q895*|FN1_ENST00000345488.5_Nonsense_Mutation_p.Q895*|FN1_ENST00000336916.4_Nonsense_Mutation_p.Q895*			P02751	FINC_HUMAN	fibronectin 1	895	Fibronectin type-III 3.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTTTCTTGTTGAATGACAACA	0.423000													7	91					0	0	0.003080	0	0
ESRRB	2103	broad.mit.edu	37	14	76948948	76948948	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:76948948G>A	ENST00000380887.2	+	5	705	c.633G>A	c.(631-633)aaG>aaA	p.K211K	ESRRB_ENST00000261532.7_Silent_p.K211K|ESRRB_ENST00000556177.1_Silent_p.K211K|ESRRB_ENST00000509242.1_Silent_p.K211K			A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	211						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(234;0.0213)		CAGTGACCAAGATTGTCTCAT	0.557000													5	46					0	0	0.001984	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156926341	156926341	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:156926341G>A	ENST00000368194.3	-	19	2581	c.1542C>T	c.(1540-1542)ttC>ttT	p.F514F	ARHGEF11_ENST00000361409.2_Silent_p.F474F	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	474					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TATTGAGGGCGAAGTCCATGG	0.527000													5	101					0	0	0.001984	0	0
MCHR2	84539	broad.mit.edu	37	6	100368900	100368900	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:100368900G>A	ENST00000281806.2	-	6	1253	c.939C>T	c.(937-939)ttC>ttT	p.F313F	MCHR2_ENST00000369212.1_Silent_p.F313F|MCHR2_ENST00000445970.1_Silent_p.F313F	NM_001040179.1	NP_001035269.1	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	313						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	39		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		GACGTTTCTGGAAATTTCCAC	0.438000													9	119					0	0	0.008291	0	0
C2	717	broad.mit.edu	37	6	31912759	31912759	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:31912759G>A	ENST00000299367.5	+	17	2308	c.2032G>A	c.(2032-2034)Gaa>Aaa	p.E678K	C2_ENST00000469372.1_Missense_Mutation_p.E432K|CFB_ENST00000477310.1_Intron|C2_ENST00000468407.1_3'UTR|CFB_ENST00000456570.1_Intron|CFB_ENST00000556679.1_Intron|C2_ENST00000452323.2_Missense_Mutation_p.E464K|C2_ENST00000442278.2_Missense_Mutation_p.E546K	NM_000063.4	NP_000054.2			complement component 2											haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(1)|skin(2)|urinary_tract(2)	27		Ovarian(999;0.00965)		LUAD - Lung adenocarcinoma(999;0.247)		GCTGGCAGGAGAATCTGGGGG	0.542000													17	486					0	0	0.008871	0	0
MMD2	221938	broad.mit.edu	37	7	4965083	4965083	+	Splice_Site	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:4965083G>A	ENST00000404774.3	-	2	322	c.129_splice	c.e2+1	p.A43_splice	MMD2_ENST00000406755.1_Splice_Site_p.A43_splice|MMD2_ENST00000401401.3_Splice_Site_p.A43_splice	NM_001100600.1	NP_001094070.1	Q8IY49	PAQRA_HUMAN	monocyte to macrophage differentiation-associated 2	43						integral to membrane	receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(11)	14		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.097)|OV - Ovarian serous cystadenocarcinoma(56;3.4e-14)		CCAACTCACAGCATGGGTGGC	0.587000													6	113					0	0	0.001984	0	0
VPS28	51160	broad.mit.edu	37	8	145650164	145650164	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr8:145650164G>A	ENST00000377348.2	-	7	428	c.339C>T	c.(337-339)gaC>gaT	p.D113D	VPS28_ENST00000292510.4_Silent_p.D113D|VPS28_ENST00000526054.1_Silent_p.D113D|VPS28_ENST00000529182.1_Silent_p.D113D	NM_183057.1	NP_898880.1	Q9UK41	VPS28_HUMAN	vacuolar protein sorting 28 homolog (S. cerevisiae)	113	VPS28 N-terminal.				cellular membrane organization|endosome transport|negative regulation of protein ubiquitination|protein transport	cytosol|late endosome membrane|plasma membrane	protein binding			kidney(1)|large_intestine(1)|lung(4)|prostate(1)	7	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			TGATGGGCCGGTCCTCCTTGA	0.667000													6	91					0	0	0.001168	0	0
PLCB4	5332	broad.mit.edu	37	20	9438063	9438063	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr20:9438063G>A	ENST00000378501.2	+	30	2978	c.2963G>A	c.(2962-2964)gGa>gAa	p.G988E	PLCB4_ENST00000278655.4_Missense_Mutation_p.G988E|PLCB4_ENST00000414679.2_Missense_Mutation_p.G1000E|PLCB4_ENST00000334005.3_Missense_Mutation_p.G988E|PLCB4_ENST00000378493.1_Missense_Mutation_p.G988E|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000378473.3_Missense_Mutation_p.G1000E	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	988					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						ATTTTCAGGGGAAGTAATTGT	0.348000													4	49					0	0	0.000602	0	0
FTH1	2495	broad.mit.edu	37	11	61732984	61732984	+	Missense_Mutation	SNP	A	A	G			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr11:61732984A>G	ENST00000273550.7	-	2	352	c.118T>C	c.(118-120)Tac>Cac	p.Y40H	FTH1_ENST00000529631.1_Intron|FTH1_ENST00000532601.1_5'UTR|FTH1_ENST00000529191.1_Intron|BEST1_ENST00000449131.2_3'UTR|FTH1_ENST00000526640.1_Missense_Mutation_p.Y10H	NM_002032.2	NP_002023.2	P02794	FRIH_HUMAN	ferritin, heavy polypeptide 1	40	Ferritin-like diiron.				cell proliferation|cellular membrane organization|immune response|intracellular sequestering of iron ion|iron ion transport|negative regulation of cell proliferation|post-Golgi vesicle-mediated transport	cytosol|intracellular ferritin complex	ferric iron binding|ferroxidase activity|protein binding			NS(2)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8					Iron Dextran(DB00893)	TCAAAGTAGTAAGACTGAAAG	0.473000													5	92					0	0	0.000602	0	0
TRPM2	7226	broad.mit.edu	37	21	45838352	45838352	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr21:45838352G>A	ENST00000397928.1	+	22	3820	c.3375G>A	c.(3373-3375)gaG>gaA	p.E1125E	TRPM2_ENST00000397932.2_Silent_p.E1125E|TRPM2_ENST00000300482.5_Silent_p.E1125E|TRPM2_ENST00000300481.9_Silent_p.E1105E|TRPM2_ENST00000498430.1_3'UTR	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	1125						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						TATCCTGGGAGATCTACCTGA	0.592000													5	136					0	0	0.000602	0	0
CREB5	9586	broad.mit.edu	37	7	28610108	28610108	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:28610108G>A	ENST00000357727.2	+	5	807	c.417G>A	c.(415-417)caG>caA	p.Q139Q	CREB5_ENST00000396300.2_Silent_p.Q132Q|CREB5_ENST00000409603.1_Silent_p.Q106Q|CREB5_ENST00000396299.2_Silent_p.Q106Q	NM_182898.2	NP_878901.2	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	139					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(13)|prostate(1)|skin(3)	32						CGTCGCCTCAGTCCAGCTCTG	0.617000													22	429					0	0	0.012319	0	0
NBEAL1	65065	broad.mit.edu	37	2	203972708	203972708	+	Silent	SNP	A	A	G			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:203972708A>G	ENST00000449802.1	+	13	1992	c.1659A>G	c.(1657-1659)gcA>gcG	p.A553A		NM_001114132.1	NP_001107604.1	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1	553							binding			NS(1)|breast(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						TGACTCGAGCAATCCTGACAA	0.463000													14	532					0	0	0.004007	0	0
KIF21B	23046	broad.mit.edu	37	1	200967660	200967660	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:200967660G>A	ENST00000332129.2	-	14	2245	c.1929C>T	c.(1927-1929)atC>atT	p.I643I	KIF21B_ENST00000360529.5_Silent_p.I643I|KIF21B_ENST00000422435.2_Silent_p.I643I|KIF21B_ENST00000461742.2_Silent_p.I643I	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	643					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						GCTTGATTTCGATCTCACAAG	0.572000													5	76					0	0	0.000602	0	0
ZMYND8	23613	broad.mit.edu	37	20	45905214	45905214	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr20:45905214G>A	ENST00000311275.7	-	11	1517	c.1264C>T	c.(1264-1266)Cgc>Tgc	p.R422C	ZMYND8_ENST00000446994.2_Missense_Mutation_p.R359C|ZMYND8_ENST00000458360.2_Missense_Mutation_p.R417C|ZMYND8_ENST00000461685.1_Missense_Mutation_p.R442C|ZMYND8_ENST00000540497.1_Missense_Mutation_p.R417C|ZMYND8_ENST00000355972.4_Missense_Mutation_p.R422C|ZMYND8_ENST00000352431.2_Missense_Mutation_p.R442C|ZMYND8_ENST00000262975.4_Missense_Mutation_p.R422C|ZMYND8_ENST00000396281.4_Missense_Mutation_p.R422C|ZMYND8_ENST00000536340.1_Missense_Mutation_p.R449C|ZMYND8_ENST00000372023.3_Missense_Mutation_p.R417C|ZMYND8_ENST00000360911.3_Missense_Mutation_p.R417C|ZMYND8_ENST00000471951.2_Missense_Mutation_p.R442C|ZMYND8_ENST00000468376.2_5'UTR			Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8	422							protein binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|prostate(3)|skin(2)|urinary_tract(8)	62			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			GAAATCCGGCGGCCTGTGCCC	0.577000													4	99					0	0	0.009096	0	0
LILRB4	11006	broad.mit.edu	37	19	55175871	55175871	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:55175871G>A	ENST00000391736.1	+	6	905	c.590G>A	c.(589-591)aGc>aAc	p.S197N	LILRB4_ENST00000391734.3_Missense_Mutation_p.S197N|LILRB4_ENST00000391733.3_Missense_Mutation_p.S197N|LILRB4_ENST00000270452.2_Missense_Mutation_p.S197N|LILRB4_ENST00000430952.2_Missense_Mutation_p.S197N	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	197	Ig-like C2-type 2.					integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		AGGTGCTTCAGCTCACACGGC	0.592000													4	62					0	0	0.009096	0	0
NELL2	4753	broad.mit.edu	37	12	45105149	45105149	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr12:45105149G>A	ENST00000429094.2	-	11	1619	c.1115C>T	c.(1114-1116)tCa>tTa	p.S372L	NELL2_ENST00000437801.2_Missense_Mutation_p.S422L|NELL2_ENST00000452445.2_Missense_Mutation_p.S372L|NELL2_ENST00000551601.1_Missense_Mutation_p.S371L|NELL2_ENST00000549027.1_Missense_Mutation_p.S371L|NELL2_ENST00000395487.2_Missense_Mutation_p.S371L|NELL2_ENST00000333837.4_Missense_Mutation_p.S395L	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	372	VWFC 2.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		TGGACAGCCTGAACTCTCAAC	0.388000													4	40					0	0	0.000602	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72657888	72657888	+	RNA	SNP	A	A	C			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:72657888A>C	ENST00000425256.1	-	0	2023					NR_002164.1																						tcaaccaagaaggccaggtct	0.488000													4	111					0	0	0.000602	0	0
SULT2A1	6822	broad.mit.edu	37	19	48389444	48389444	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:48389444C>T	ENST00000222002.3	-	1	210	c.71G>A	c.(70-72)aGa>aAa	p.R24K		NM_003167.3	NP_003158.2	Q06520	ST2A1_HUMAN	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	24					3'-phosphoadenosine 5'-phosphosulfate metabolic process|bile acid catabolic process|cellular lipid metabolic process|digestion|sulfation|xenobiotic metabolic process	cytosol	bile-salt sulfotransferase activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)	20		all_cancers(25;3.02e-09)|all_lung(116;6.48e-07)|all_epithelial(76;7.35e-07)|Lung NSC(112;1.56e-06)|all_neural(266;0.0146)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000254)|all cancers(93;0.000545)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.0552)		ACGTACTTTTCTTAAGGTTTC	0.428000													8	109					0	0	0.004482	0	0
TRAV7	28686	broad.mit.edu	37	14	22251601	22251601	+	RNA	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:22251601C>T	ENST00000390429.3	+	0	218																											TCCATGTATTCAGCTGGATAT	0.453000													4	39					0	0	0.009096	0	0
RP1	6101	broad.mit.edu	37	8	55541534	55541534	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr8:55541534G>A	ENST00000220676.1	+	4	5240	c.5092G>A	c.(5092-5094)Gag>Aag	p.E1698K		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1698					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GGAATTCCAGGAGGAAAGACA	0.403000													4	81					0	0	0.009096	0	0
OR2Z1	284383	broad.mit.edu	37	19	8841876	8841876	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:8841876C>T	ENST00000324060.2	+	1	561	c.486C>T	c.(484-486)atC>atT	p.I162I		NM_001004699.1	NP_001004699.1	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z, member 1	162					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						AGACCTCCATCACCCTGCATT	0.552000													10	126					0	0	0.010729	0	0
DMC1	11144	broad.mit.edu	37	22	38917729	38917729	+	Splice_Site	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr22:38917729G>A	ENST00000216024.2	-	13	1113	c.836_splice	c.e13-1	p.T279_splice	DMC1_ENST00000428462.2_Splice_Site_p.T224_splice	NM_007068.2	NP_008999.2	Q14565	DMC1_HUMAN	DNA meiotic recombinase 1	279					reciprocal meiotic recombination	condensed nuclear chromosome	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			large_intestine(5)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11	Melanoma(58;0.0286)					CTGCCTGAAAGCTGAATTAAT	0.408000								Homologous recombination					8	80					0	0	0.003080	0	0
TUBAL3	79861	broad.mit.edu	37	10	5435999	5435999	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr10:5435999G>A	ENST00000380419.3	-	4	859	c.822C>T	c.(820-822)ttC>ttT	p.F274F	TUBAL3_ENST00000479328.1_Silent_p.F234F	NM_024803.2	NP_079079.1	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	274					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(7)|prostate(2)|skin(3)	25						CTGTCATGGGGAAATGTATTC	0.512000													10	170					0	0	0.008291	0	0
YWHAE	7531	broad.mit.edu	37	17	1264404	1264404	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:1264404G>A	ENST00000264335.8	-	4	827	c.560C>T	c.(559-561)tCc>tTc	p.S187F	YWHAE_ENST00000575977.1_Intron|YWHAE_ENST00000573026.1_Intron|YWHAE_ENST00000571732.1_Missense_Mutation_p.S165F	NM_006761.4	NP_006752.1	P62258	1433E_HUMAN	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	187					apoptosis|G2/M transition of mitotic cell cycle|induction of apoptosis by extracellular signals|interspecies interaction between organisms|intracellular signal transduction|nerve growth factor receptor signaling pathway	cytosol|melanosome	histone deacetylase binding|phosphoserine binding			kidney(2)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(18;0.203)	UCEC - Uterine corpus endometrioid carcinoma (25;0.0887)		ACGGTCAGGGGAATTAAGAAT	0.483000			T	"""FAM22a, FAM22B"""	edometrial stromal sarcoma		Miller-Dieker lissencephaly syndrome						6	70					0	0	0.003080	0	0
CRIPAK	285464	broad.mit.edu	37	4	1388638	1388638	+	Silent	SNP	A	A	G			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr4:1388638A>G	ENST00000324803.4	+	1	3299	c.339A>G	c.(337-339)ggA>ggG	p.G113G		NM_175918.3	NP_787114.2	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	113					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding			NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(1)	35			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			GCCCATGTGGAGTGCCCGCCT	0.677000													4	186					0	0	0.001168	0	0
PSG8	440533	broad.mit.edu	37	19	43258618	43258618	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:43258618C>T	ENST00000404209.4	-	5	1206	c.1110G>A	c.(1108-1110)ggG>ggA	p.G370G	PSG8_ENST00000306511.4_Silent_p.G370G|PSG8_ENST00000600709.1_5'UTR|PSG8_ENST00000406636.3_Silent_p.G248G|PSG8_ENST00000401467.2_Silent_p.G277G	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	370	Ig-like C2-type 3.					extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				GCTGAAACTTCCCATTAATTG	0.463000													15	258					0	0	0.006122	0	0
GIMAP8	155038	broad.mit.edu	37	7	150174698	150174698	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:150174698C>T	ENST00000307271.3	+	5	2402	c.1828C>T	c.(1828-1830)Cag>Tag	p.Q610*		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	610						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		AGGCCAGGCCCAGGAAACCCA	0.458000													5	122					0	0	0.001168	0	0
EGFLAM	133584	broad.mit.edu	37	5	38427349	38427349	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr5:38427349C>T	ENST00000322350.5	+	14	2395	c.2049C>T	c.(2047-2049)gtC>gtT	p.V683V	EGFLAM_ENST00000354891.3_Silent_p.V683V|EGFLAM_ENST00000336740.6_Silent_p.V449V|EGFLAM_ENST00000397202.2_Silent_p.V49V|EGFLAM-AS1_ENST00000508986.1_RNA	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	683	Laminin G-like 2.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					GGACCGGTGTCCTCAGGTGAG	0.502000													10	179					0	0	0.010729	0	0
NF1	4763	broad.mit.edu	37	17	29687605	29687605	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:29687605C>T	ENST00000358273.4	+	57	8644	c.8261C>T	c.(8260-8262)tCc>tTc	p.S2754F	NF1_ENST00000356175.3_Missense_Mutation_p.S2733F|NF1_ENST00000417592.2_3'UTR|NF1_ENST00000444181.2_Missense_Mutation_p.S547F	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	2754					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(3)|p.S2751fs*27(1)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AGTGAAGAATCCCTCCTGACT	0.448000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			8	96					0	0	0.003080	0	0
TRPC4	7223	broad.mit.edu	37	13	38320170	38320170	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr13:38320170G>A	ENST00000379705.3	-	3	1658	c.801C>T	c.(799-801)atC>atT	p.I267I	TRPC4_ENST00000426868.2_Silent_p.I267I|TRPC4_ENST00000358477.2_Silent_p.I267I|TRPC4_ENST00000447043.1_Silent_p.I267I|TRPC4_ENST00000379679.1_Intron|TRPC4_ENST00000338947.5_Intron|TRPC4_ENST00000379681.3_Silent_p.I267I|TRPC4_ENST00000355779.2_Silent_p.I267I|TRPC4_ENST00000379673.2_Silent_p.I267I			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	267	Multimerization domain (By similarity).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		AATTAAGAATGATTTCCAGTT	0.393000													5	136					0	0	0.000602	0	0
GALNT14	79623	broad.mit.edu	37	2	31215756	31215756	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:31215756C>T	ENST00000349752.5	-	2	886	c.247G>A	c.(247-249)Gag>Aag	p.E83K	GALNT14_ENST00000420311.2_Missense_Mutation_p.E48K|GALNT14_ENST00000324589.5_Intron|GALNT14_ENST00000406653.1_Missense_Mutation_p.E63K|GALNT14_ENST00000356174.3_Missense_Mutation_p.E83K	NM_024572.3	NP_078848.2	Q96FL9	GLT14_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)	83						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(3)|large_intestine(10)|liver(1)|lung(21)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)	43	Acute lymphoblastic leukemia(172;0.155)					CGCTCACTCTCCCGCTGGTTG	0.562000													5	88					0	0	0.000602	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94639975	94639975	+	Missense_Mutation	SNP	T	T	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:94639975T>A	ENST00000260526.6	-	23	3418	c.3236A>T	c.(3235-3237)aAa>aTa	p.K1079I		NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	1079					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		GTCCTGAATTTTCTGTAGAGT	0.413000													6	186					0	0	0.001168	0	0
CRB1	23418	broad.mit.edu	37	1	197404165	197404165	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:197404165G>A	ENST00000367397.1	+	5	2173	c.1315G>A	c.(1315-1317)Gaa>Aaa	p.E439K	CRB1_ENST00000535699.1_Missense_Mutation_p.E1034K|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000367400.3_Missense_Mutation_p.E1058K|CRB1_ENST00000367399.2_Missense_Mutation_p.E946K|CRB1_ENST00000544212.1_Missense_Mutation_p.E539K			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1058	EGF-like 10; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding	p.E1058K(1)		NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						AGTGGACAACGAAACACCTTT	0.443000													6	67					0	0	0.001168	0	0
SRL	6345	broad.mit.edu	37	16	4242622	4242622	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr16:4242622C>T	ENST00000399609.3	-	6	966	c.954G>A	c.(952-954)ctG>ctA	p.L318L	SRL_ENST00000537996.1_Silent_p.L276L	NM_001098814.1	NP_001092284.1	Q86TD4	SRCA_HUMAN	sarcalumenin	777	Acidic domain, probably binds calcium (By similarity).					sarcoplasmic reticulum lumen	GTP binding|GTPase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(3)|skin(3)	21						TCACCTGATTCAGGTCTTCTA	0.562000													6	131					0	0	0.003080	0	0
MAGEA6	4105	broad.mit.edu	37	X	151870034	151870034	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:151870034C>T	ENST00000329342.5	+	3	949	c.724C>T	c.(724-726)Ccc>Tcc	p.P242S		NM_005363.2	NP_005354.1	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	242	MAGE.						protein binding			breast(1)|endometrium(3)|large_intestine(3)|lung(16)|prostate(3)|skin(1)|urinary_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					CTTCGGGGATCCCAAGAAGCT	0.547000													9	107					0	0	0.008291	0	0
PRKCZ	5590	broad.mit.edu	37	1	2082350	2082350	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:2082350G>A	ENST00000400921.2	+	6	943	c.260G>A	c.(259-261)cGg>cAg	p.R87Q	PRKCZ_ENST00000400920.1_Missense_Mutation_p.R87Q|PRKCZ_ENST00000479263.1_3'UTR	NM_001033581.1	NP_001028753.1	Q05513	KPCZ_HUMAN	protein kinase C, zeta	270	Interaction with SQSTM1 (By similarity).|OPR.				anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			breast(2)|central_nervous_system(4)|endometrium(1)|large_intestine(5)|lung(5)|stomach(1)	18	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)		CTCCTGGTGCGGTTGAAGAAG	0.557000													4	67					0	0	0.000602	0	0
SV2B	9899	broad.mit.edu	37	15	91835678	91835678	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:91835678G>A	ENST00000394232.1	+	13	2418	c.1948G>A	c.(1948-1950)Ggg>Agg	p.G650R	SV2B_ENST00000545111.2_Missense_Mutation_p.G499R|SV2B_ENST00000330276.4_Missense_Mutation_p.G650R	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B	650					neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			TTCTTTTGTTGGGATAACCAA	0.498000													39	616					0	0	0.009718	0	0
LTF	4057	broad.mit.edu	37	3	46487963	46487963	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:46487963G>A	ENST00000231751.4	-	11	1620	c.1325C>T	c.(1324-1326)cCt>cTt	p.P442L	LTF_ENST00000417439.1_Missense_Mutation_p.P440L|LTF_ENST00000426532.2_Missense_Mutation_p.P398L	NM_002343.3	NP_002334.2	P02788	TRFL_HUMAN	lactotransferrin	442	Transferrin-like 2.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	40				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	GTTAGGATCAGGGTCACTGCT	0.433000													4	86					0	0	0.009096	0	0
JDP2	122953	broad.mit.edu	37	14	75904779	75904779	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:75904779C>T	ENST00000435893.2	+	2	429	c.156C>T	c.(154-156)ttC>ttT	p.F52F	JDP2_ENST00000559773.1_3'UTR|JDP2_ENST00000419727.2_Silent_p.F52F|JDP2_ENST00000267569.5_Silent_p.F63F|JDP2_ENST00000437176.1_Silent_p.F52F	NM_001135047.1|NM_130469.3	NP_001128519.1|NP_569736.1	Q8WYK2	JDP2_HUMAN	Jun dimerization protein 2	52						nucleus	sequence-specific DNA binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(234;0.0296)		CCTTGCACTTCCTGGAGGTGA	0.607000													3	19					0	0	0.004672	0	0
TENM2	57451	broad.mit.edu	37	5	167630770	167630770	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr5:167630770C>T	ENST00000519204.1	+	17	3262	c.3144C>T	c.(3142-3144)ttC>ttT	p.F1048F	TENM2_ENST00000518659.1_Silent_p.F1169F|TENM2_ENST00000520394.1_Silent_p.F937F|TENM2_ENST00000403607.2_Silent_p.F993F|TENM2_ENST00000545108.1_Silent_p.F1169F					teneurin transmembrane protein 2									p.F1002F(1)|p.F1169F(1)									TTCAGGGATTCGAGCTGGACC	0.498000													7	124					0	0	0.003080	0	0
LAMB4	22798	broad.mit.edu	37	7	107704300	107704300	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:107704300C>T	ENST00000388781.3	-	22	3050	c.2967G>A	c.(2965-2967)ggG>ggA	p.G989G	LAMB4_ENST00000388780.3_Silent_p.G989G|LAMB4_ENST00000205386.4_Silent_p.G989G	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	989	Laminin EGF-like 10.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						GAAGGCACTCCCCTGTTACCC	0.507000													5	104					0	0	0.001168	0	0
UGT1A9	54600	broad.mit.edu	37	2	234581193	234581193	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:234581193G>A	ENST00000354728.4	+	1	695	c.613G>A	c.(613-615)Gag>Aag	p.E205K	UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A10_ENST00000344644.5_Intron	NM_021027.2	NP_066307.1														breast(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	37		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)		GACTTTCAAGGAGAGAGTACG	0.438000													7	223					0	0	0.003080	0	0
P2RY13	53829	broad.mit.edu	37	3	151046682	151046682	+	Silent	SNP	A	A	C			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:151046682A>C	ENST00000325602.5	-	2	181	c.162T>G	c.(160-162)gtT>gtG	p.V54V	MED12L_ENST00000491549.1_Intron|MED12L_ENST00000474524.1_Intron|MED12L_ENST00000273432.4_Intron	NM_176894.2	NP_795713.2	Q9BPV8	P2Y13_HUMAN	purinergic receptor P2Y, G-protein coupled, 13	54						integral to membrane|plasma membrane				biliary_tract(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	14			LUSC - Lung squamous cell carcinoma(72;0.0189)|Lung(72;0.0278)			CGGTCAAGAAAACCACTGTGT	0.507000													6	127					0	0	0.001168	0	0
ZNF611	81856	broad.mit.edu	37	19	53209792	53209792	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:53209792G>A	ENST00000543227.1	-	6	790	c.516C>T	c.(514-516)atC>atT	p.I172I	ZNF611_ENST00000453741.2_Silent_p.I103I|ZNF611_ENST00000602162.1_Silent_p.I103I|ZNF611_ENST00000319783.1_Silent_p.I172I|ZNF611_ENST00000595798.1_Silent_p.I103I|ZNF611_ENST00000540744.1_Silent_p.I172I	NM_001161499.1	NP_001154971.1	Q8N823	ZN611_HUMAN	zinc finger protein 611	172					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		TTTCACCTTTGATCTGAAATA	0.403000													6	134					0	0	0.001168	0	0
SCN7A	6332	broad.mit.edu	37	2	167262274	167262274	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:167262274C>T	ENST00000409855.1	-	25	4991	c.4865G>A	c.(4864-4866)cGa>cAa	p.R1622Q		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	1622					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						CTCTTGTTTTCGTTTCAAAGT	0.363000													7	173					0	0	0.001984	0	0
GALNT16	57452	broad.mit.edu	37	14	69792741	69792741	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:69792741G>A	ENST00000337827.4	+	5	892	c.565G>A	c.(565-567)Gaa>Aaa	p.E189K	GALNT16_ENST00000448469.3_Missense_Mutation_p.E189K|GALNT16_ENST00000553669.1_Missense_Mutation_p.E189K	NM_001168368.1|NM_020692.2	NP_001161840.1|NP_065743.2			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16																		TGATCGGCGGGAAGGTGAGTC	0.572000													7	55					0	0	0.001984	0	0
LILRA1	11024	broad.mit.edu	37	19	55107142	55107142	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:55107142C>T	ENST00000251372.3	+	6	882	c.700C>T	c.(700-702)Cct>Tct	p.P234S	LILRB1_ENST00000396321.2_Intron|LILRB1_ENST00000448689.1_Intron|LILRA1_ENST00000453777.1_Intron|LILRA1_ENST00000473156.1_Intron|LILRB1_ENST00000418536.2_Intron	NM_006863.1	NP_006854.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	234	Ig-like C2-type 3.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		GCAGCCAGGTCCTATAGTGGC	0.537000													5	109					0	0	0.001984	0	0
DIDO1	11083	broad.mit.edu	37	20	61513451	61513451	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr20:61513451G>A	ENST00000266070.4	-	16	4182	c.3857C>T	c.(3856-3858)cCa>cTa	p.P1286L	DIDO1_ENST00000395343.1_Missense_Mutation_p.P1286L	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1286	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					TGCTGTGGCTGGGCTGGGGGC	0.642000													8	88					0	0	0.008291	0	0
APOBEC3G	60489	broad.mit.edu	37	22	39482342	39482342	+	Missense_Mutation	SNP	T	T	G			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr22:39482342T>G	ENST00000407997.3	+	6	1151	c.794T>G	c.(793-795)gTg>gGg	p.V265G	APOBEC3G_ENST00000452957.2_Missense_Mutation_p.V265G	NM_021822.3	NP_068594.1			apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G											central_nervous_system(1)|large_intestine(4)|lung(5)|skin(1)|stomach(1)	12	Melanoma(58;0.04)					TTCCTGGACGTGATTCCCTTT	0.498000													5	84					0	0	0.001168	0	0
COL6A2	1292	broad.mit.edu	37	21	47541503	47541503	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr21:47541503C>T	ENST00000300527.4	+	18	1596	c.1492C>T	c.(1492-1494)Cgt>Tgt	p.R498C	COL6A2_ENST00000409416.1_Missense_Mutation_p.R498C|COL6A2_ENST00000310645.5_Missense_Mutation_p.R498C|COL6A2_ENST00000397763.1_Missense_Mutation_p.R498C|COL6A2_ENST00000357838.4_Missense_Mutation_p.R498C	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	498	Triple-helical region.		R -> H (in UCMD).		axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		TGCAGGACCCCGTGGAGACTC	0.657000													3	23					0	0	0.009096	0	0
NLRP5	126206	broad.mit.edu	37	19	56539771	56539771	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:56539771C>T	ENST00000390649.3	+	7	2172	c.2172C>T	c.(2170-2172)tcC>tcT	p.S724S		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	724						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TAGCATCTTCCTTCTGCCTCC	0.488000													9	180					0	0	0.008291	0	0
KCNQ5	56479	broad.mit.edu	37	6	73904714	73904714	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:73904714G>A	ENST00000342056.2	+	15	2831	c.2433G>A	c.(2431-2433)caG>caA	p.Q811Q	KCNQ5_ENST00000402622.2_Silent_p.Q802Q|KCNQ5_ENST00000414165.2_Silent_p.Q682Q|KCNQ5_ENST00000403813.2_Silent_p.Q783Q|KCNQ5_ENST00000370398.1_Silent_p.Q792Q|KCNQ5_ENST00000355635.3_Silent_p.Q793Q|KCNQ5_ENST00000355194.4_Silent_p.Q792Q	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	792					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		AAAATGTTCAGGTTGCACAGT	0.507000													4	62					0	0	0.009096	0	0
FN1	2335	broad.mit.edu	37	2	216289870	216289870	+	Missense_Mutation	SNP	T	T	C			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:216289870T>C	ENST00000354785.4	-	7	1352	c.983A>G	c.(982-984)aAt>aGt	p.N328S	FN1_ENST00000323926.6_Missense_Mutation_p.N328S|FN1_ENST00000359671.1_Missense_Mutation_p.N328S|FN1_ENST00000426059.1_Missense_Mutation_p.N328S|FN1_ENST00000446046.1_Missense_Mutation_p.N328S|FN1_ENST00000443816.1_Missense_Mutation_p.N328S|FN1_ENST00000432072.2_Missense_Mutation_p.N328S|FN1_ENST00000421182.1_Missense_Mutation_p.N328S|FN1_ENST00000357867.4_Missense_Mutation_p.N328S|FN1_ENST00000357009.2_Missense_Mutation_p.N328S|FN1_ENST00000356005.4_Missense_Mutation_p.N328S|FN1_ENST00000346544.3_Missense_Mutation_p.N328S|FN1_ENST00000345488.5_Missense_Mutation_p.N328S|FN1_ENST00000336916.4_Missense_Mutation_p.N328S			P02751	FINC_HUMAN	fibronectin 1	328	Collagen-binding.|Fibronectin type-I 6.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CATTTGCTTATTTCCTTGTGT	0.498000													8	230					0	0	0.003080	0	0
MUC16	94025	broad.mit.edu	37	19	9026227	9026227	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:9026227C>T	ENST00000397910.4	-	14	36962	c.36759G>A	c.(36757-36759)agG>agA	p.R12253R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12255	SEA 2.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTTGAACTTCCTGGAGCCAG	0.562000													6	166					0	0	0.001168	0	0
OR4K1	79544	broad.mit.edu	37	14	20404655	20404655	+	Missense_Mutation	SNP	T	T	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:20404655T>A	ENST00000285600.4	+	1	889	c.830T>A	c.(829-831)gTt>gAt	p.V277D		NM_001004063.2	NP_001004063.2	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K, member 1	277					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		TTCTACACTGTTTGTACTCCC	0.418000													5	168					0	0	0.000602	0	0
PIGC	5279	broad.mit.edu	37	1	172411668	172411668	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:172411668C>T	ENST00000367728.1	-	1	1558	c.95G>A	c.(94-96)cGa>cAa	p.R32Q	PIGC_ENST00000344529.4_Missense_Mutation_p.R32Q|PIGC_ENST00000258324.1_Missense_Mutation_p.R32Q|PIGC_ENST00000484368.1_Intron|C1orf105_ENST00000367727.4_Intron			Q92535	PIGC_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class C	32					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			breast(1)|endometrium(1)|kidney(1)|lung(1)	4						TTCCAGGAATCGCCGGTCCAC	0.488000													5	113					0	0	0.001168	0	0
HNF1A	6927	broad.mit.edu	37	12	121431342	121431342	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr12:121431342G>A	ENST00000257555.6	+	3	772	c.546G>A	c.(544-546)caG>caA	p.Q182Q	HNF1A_ENST00000544413.1_Silent_p.Q182Q|HNF1A_ENST00000400024.2_Silent_p.Q182Q|HNF1A_ENST00000402929.1_Silent_p.Q182Q|HNF1A_ENST00000541395.1_Silent_p.Q182Q|HNF1A_ENST00000543427.1_Silent_p.Q65Q|HNF1A_ENST00000538626.1_Intron			P20823	HNF1A_HUMAN	HNF1 homeobox A	182					glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(8)|large_intestine(19)|liver(175)|lung(9)|ovary(2)|prostate(1)|urinary_tract(1)	221	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ATGCAGGGCAGGGAGGGCTGA	0.592000									Hepatic Adenoma, Familial Clustering of				15	374					0	0	0.004007	0	0
DZIP1L	199221	broad.mit.edu	37	3	137790621	137790621	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:137790621G>A	ENST00000327532.2	-	12	1841	c.1479C>T	c.(1477-1479)gtC>gtT	p.V493V	DZIP1L_ENST00000469243.1_Silent_p.V493V|DZIP1L_ENST00000488595.1_Intron	NM_173543.2	NP_775814.2	Q8IYY4	DZI1L_HUMAN	DAZ interacting zinc finger protein 1-like	493						intracellular	zinc ion binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(2)|prostate(1)|skin(1)	35						GCTCCCGCTGGACTCTCAGCA	0.517000													10	196					0	0	0.008291	0	0
OR9A4	130075	broad.mit.edu	37	7	141618723	141618723	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:141618723C>T	ENST00000548136.1	+	1	107	c.48C>T	c.(46-48)ttC>ttT	p.F16F	MGAM_ENST00000497554.1_Intron	NM_001001656.1	NP_001001656.1	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A, member 4	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|large_intestine(9)|lung(7)|prostate(1)|skin(2)	22	Melanoma(164;0.0171)					TCCTTGGCTTCCCTGGCTCTG	0.378000													8	147					0	0	0.004482	0	0
ZNF543	125919	broad.mit.edu	37	19	57838039	57838039	+	Missense_Mutation	SNP	G	G	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:57838039G>T	ENST00000321545.4	+	3	529	c.184G>T	c.(184-186)Gat>Tat	p.D62Y		NM_213598.3	NP_998763.2	Q08ER8	ZN543_HUMAN	zinc finger protein 543	62	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(2)|large_intestine(8)|lung(11)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	28		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CTACCAGTTGGATCACAGACA	0.498000													6	73					1.06961e-07	1.18441e-07	0.003080	1	0
CUL3	8452	broad.mit.edu	37	2	225370813	225370813	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:225370813G>A	ENST00000264414.4	-	8	1404	c.1066C>T	c.(1066-1068)Ctc>Ttc	p.L356F	CUL3_ENST00000344951.4_Missense_Mutation_p.L290F|CUL3_ENST00000409777.1_Missense_Mutation_p.L332F|CUL3_ENST00000409096.1_Missense_Mutation_p.L332F	NM_003590.4	NP_003581.1	Q13618	CUL3_HUMAN	cullin 3	356					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	46		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		GATTCCAGGAGGAAGCGATCG	0.358000													3	29					0	0	0.009096	0	0
CNN1	1264	broad.mit.edu	37	19	11657516	11657516	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:11657516C>T	ENST00000592923.1	+	4	639	c.62C>T	c.(61-63)tCc>tTc	p.S21F	CNN1_ENST00000252456.2_Missense_Mutation_p.S71F|CNN1_ENST00000535659.2_Missense_Mutation_p.S21F|CNN1_ENST00000544952.1_Missense_Mutation_p.S51F			P51911	CNN1_HUMAN	calponin 1, basic, smooth muscle	71					actomyosin structure organization|regulation of smooth muscle contraction	cytoskeleton	actin binding|calmodulin binding			breast(1)|endometrium(2)|large_intestine(4)|lung(2)	9						CAGCCAGGCTCCGTGAAGAAG	0.567000													4	102					0	0	0.009096	0	0
GLRB	2743	broad.mit.edu	37	4	158060056	158060056	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr4:158060056G>A	ENST00000264428.4	+	7	976	c.706G>A	c.(706-708)Gaa>Aaa	p.E236K	GLRB_ENST00000509282.1_Missense_Mutation_p.E236K|GLRB_ENST00000541722.1_Missense_Mutation_p.E236K|GLRB_ENST00000512619.1_Intron	NM_000824.4	NP_000815.1	P48167	GLRB_HUMAN	glycine receptor, beta	236					nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(6)|skin(5)|upper_aerodigestive_tract(1)	27	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	TATCAAAAAGGAAGATATTGA	0.299000													5	69					0	0	0.001984	0	0
TJP3	27134	broad.mit.edu	37	19	3735929	3735929	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:3735929C>T	ENST00000541714.2	+	10	1585	c.1123C>T	c.(1123-1125)Cgt>Tgt	p.R375C	TJP3_ENST00000589378.1_Missense_Mutation_p.R384C|TJP3_ENST00000382008.3_Missense_Mutation_p.R389C|TJP3_ENST00000587686.1_Missense_Mutation_p.R394C|TJP3_ENST00000262968.9_Missense_Mutation_p.R408C|TJP3_ENST00000539908.2_Missense_Mutation_p.R339C	NM_001267560.1	NP_001254489.1	O95049	ZO3_HUMAN	tight junction protein 3	389						tight junction	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		CATGGAGGATCGTGGGTATGT	0.527000													5	93					0	0	0.001168	0	0
DICER1	23405	broad.mit.edu	37	14	95584028	95584028	+	Silent	SNP	A	A	G			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:95584028A>G	ENST00000526495.1	-	11	1731	c.1440T>C	c.(1438-1440)acT>acC	p.T480T	DICER1_ENST00000541352.1_Silent_p.T480T|DICER1_ENST00000393063.1_Silent_p.T480T|DICER1_ENST00000343455.3_Silent_p.T480T|DICER1_ENST00000527414.1_Silent_p.T480T			Q9UPY3	DICER_HUMAN	dicer 1, ribonuclease type III	480	Helicase C-terminal.|Required for interaction with PRKRA and TARBP2.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		TGCCATGTCCAGTTATGAAAT	0.368000			"""Mis F, N"""		"""sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"""	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome				6	53					0	0	0.001984	0	0
FGD5	152273	broad.mit.edu	37	3	14862924	14862924	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:14862924G>A	ENST00000285046.5	+	1	2456	c.2346G>A	c.(2344-2346)tcG>tcA	p.S782S	FGD5_ENST00000543601.1_Silent_p.S541S	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	782					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						CCATGAACTCGGACTATGAGA	0.582000													8	220					0	0	0.004482	0	0
VWA3A	146177	broad.mit.edu	37	16	22166930	22166930	+	Missense_Mutation	SNP	C	C	G			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr16:22166930C>G	ENST00000389397.4	+	33	3616	c.754C>G	c.(754-756)Ctg>Gtg	p.L252V	VWA3A_ENST00000563755.1_Missense_Mutation_p.L252V|VWA3A_ENST00000389398.5_Missense_Mutation_p.L1150V			A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	1150						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		TTTAAGGATCCTGGCCCAGGA	0.512000													5	137					0	0	0.000602	0	0
GABRQ	55879	broad.mit.edu	37	X	151806767	151806767	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:151806767C>T	ENST00000370306.2	+	1	131	c.111C>T	c.(109-111)tcC>tcT	p.S37S		NM_018558.2	NP_061028.2	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) A receptor, theta	37						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(9)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	52	Acute lymphoblastic leukemia(192;6.56e-05)					TCGAGTTCTCCTCTGCTGTGC	0.632000													5	32					0	0	0.001168	0	0
ALPK2	115701	broad.mit.edu	37	18	56203320	56203320	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr18:56203320C>T	ENST00000361673.3	-	5	4312	c.4099G>A	c.(4099-4101)Gaa>Aaa	p.E1367K	RP11-1151B14.4_ENST00000591360.1_RNA	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1367							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TTAACATTTTCCTTCCCTCCA	0.453000													4	79					0	0	0.000602	0	0
VN1R2	317701	broad.mit.edu	37	19	53762361	53762361	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:53762361G>A	ENST00000341702.3	+	1	817	c.733G>A	c.(733-735)Gat>Aat	p.D245N		NM_173856.2	NP_776255.2	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	245					response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(134;0.00301)		AAAGAAAGGAGATTTGGGATA	0.428000													5	73					0	0	0.000602	0	0
IGKV2-24	28923	broad.mit.edu	37	2	89475915	89475915	+	RNA	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:89475915C>T	ENST00000484817.1	-	0	286																											GCCACTGAATCTGTCTGGGAC	0.493000													8	143					0	0	0.003080	0	0
FILIP1	27145	broad.mit.edu	37	6	76024879	76024879	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:76024879G>A	ENST00000393004.2	-	5	890	c.669C>T	c.(667-669)gcC>gcT	p.A223A	FILIP1_ENST00000237172.7_Silent_p.A223A|FILIP1_ENST00000370020.1_Silent_p.A124A|FILIP1_ENST00000498523.1_5'UTR			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	223										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						TTTCTTTGCGGGCTTGATAAG	0.338000													5	46					0	0	0.000602	0	0
RASGRF1	5923	broad.mit.edu	37	15	79339128	79339128	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:79339128G>A	ENST00000419573.3	-	5	1112	c.838C>T	c.(838-840)Ccc>Tcc	p.P280S	RASGRF1_ENST00000560334.1_5'UTR|RASGRF1_ENST00000558480.2_Missense_Mutation_p.P280S	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	280	DH.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						TGTGTGATGGGAGGCTTCTTG	0.592000													12	137					0	0	0.001855	0	0
C6orf201	404220	broad.mit.edu	37	6	4099407	4099407	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:4099407C>T	ENST00000380175.4	+	3	1024	c.259C>T	c.(259-261)Cct>Tct	p.P87S	C6orf201_ENST00000430835.2_Missense_Mutation_p.P87S|C6orf201_ENST00000360378.6_3'UTR|C6orf201_ENST00000333388.5_Missense_Mutation_p.P90S	NM_001085401.2	NP_001078870.1	Q7Z4U5	CF201_HUMAN	chromosome 6 open reading frame 201	87										central_nervous_system(1)|endometrium(3)|lung(2)	6	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				CACGAAAGAGCCTCCAATGTC	0.413000													4	29					0	0	0.001168	0	0
CRYGB	1419	broad.mit.edu	37	2	209007617	209007617	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:209007617C>T	ENST00000260988.4	-	3	320	c.273G>A	c.(271-273)atG>atA	p.M91I		NM_005210.3	NP_005201.2	P07316	CRGB_HUMAN	crystallin, gamma B	91	Beta/gamma crystallin 'Greek key' 3.				visual perception		structural constituent of eye lens			cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|stomach(1)	14				Epithelial(149;0.0641)|LUSC - Lung squamous cell carcinoma(261;0.0703)|Lung(261;0.132)		CGTAGATCTTCATTCTGTAAG	0.473000													5	133					0	0	0.004482	0	0
FLG	2312	broad.mit.edu	37	1	152284324	152284324	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:152284324G>A	ENST00000368799.1	-	3	3073	c.3038C>T	c.(3037-3039)tCc>tTc	p.S1013F	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1013	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCACCAGAGGAAGTCTCTGC	0.587000									Ichthyosis				10	393					0	0	0.008291	0	0
CLEC4E	26253	broad.mit.edu	37	12	8692542	8692542	+	Splice_Site	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr12:8692542C>T	ENST00000299663.3	-	2	204	c.37_splice	c.e2-1	p.E13_splice	CLEC4E_ENST00000545274.1_Splice_Site_p.E13_splice|CLEC4E_ENST00000446457.2_Splice_Site_p.E13_splice	NM_014358.2	NP_055173.1	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	13						integral to membrane	sugar binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12	Lung SC(5;0.184)					AGCATCCTCTCTCTGTAGAAA	0.403000													5	126					0	0	0.000602	0	0
NLRP7	199713	broad.mit.edu	37	19	55450557	55450557	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:55450557G>A	ENST00000588756.1	-	6	2116	c.1630C>T	c.(1630-1632)Ccg>Tcg	p.P544S	NLRP7_ENST00000592784.1_Missense_Mutation_p.P544S|NLRP7_ENST00000590030.1_Missense_Mutation_p.P544S|NLRP7_ENST00000340844.2_Missense_Mutation_p.P544S|NLRP7_ENST00000328092.5_Missense_Mutation_p.P544S|NLRP7_ENST00000446217.1_Missense_Mutation_p.P572S|NLRP7_ENST00000448121.2_Missense_Mutation_p.P544S			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	544							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		TTGATGTCCGGTGACATCCGG	0.512000													5	76					0	0	0.000602	0	0
CLDN11	5010	broad.mit.edu	37	3	170150390	170150390	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:170150390C>T	ENST00000064724.3	+	3	672	c.470C>T	c.(469-471)tCc>tTc	p.S157F	CLDN11_ENST00000489485.1_3'UTR|CLDN11_ENST00000451576.1_Intron|CLDN11_ENST00000486975.1_Intron	NM_005602.5	NP_005593.2	O75508	CLD11_HUMAN	claudin 11	157					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			central_nervous_system(2)|endometrium(2)|large_intestine(1)|liver(2)|lung(3)|ovary(2)	12	all_cancers(22;5.62e-23)|all_epithelial(15;7.54e-28)|all_lung(20;2.51e-17)|Lung NSC(18;1.02e-16)|Ovarian(172;0.000567)|Breast(254;0.137)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			TTTGGCTACTCCCTGTATGCA	0.602000													5	92					0	0	0.001168	0	0
ADAD2	161931	broad.mit.edu	37	16	84230291	84230291	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr16:84230291C>T	ENST00000268624.3	+	10	1904	c.1811C>T	c.(1810-1812)tCc>tTc	p.S604F	RP11-486L19.2_ENST00000565643.1_RNA|ADAD2_ENST00000315906.5_Missense_Mutation_p.S522F|RP11-486L19.2_ENST00000536986.1_RNA|RP11-486L19.2_ENST00000569834.1_RNA	NM_139174.3	NP_631913.3	Q8NCV1	ADAD2_HUMAN	adenosine deaminase domain containing 2	522					RNA processing	intracellular	adenosine deaminase activity|double-stranded RNA binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|skin(1)	13						TGCAAGGCCTCCTTTCTCCGG	0.627000													5	144					0	0	0.000602	0	0
BEND2	139105	broad.mit.edu	37	X	18221933	18221933	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:18221933C>T	ENST00000380033.4	-	5	727	c.595G>A	c.(595-597)Gaa>Aaa	p.E199K	BEND2_ENST00000380030.3_Missense_Mutation_p.E199K	NM_153346.4	NP_699177.2	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	199										NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(11)|liver(1)|lung(21)|ovary(3)|prostate(1)	49						AGGTCTGCTTCCTGCAGTTCA	0.488000													16	96					0	0	0.003163	0	0
KCNH5	27133	broad.mit.edu	37	14	63174717	63174717	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr14:63174717C>T	ENST00000322893.7	-	11	2744	c.2476G>A	c.(2476-2478)Gaa>Aaa	p.E826K	KCNH5_ENST00000420622.2_3'UTR	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	826					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TTCCAGTCTTCCTTTTTCTCC	0.433000													8	91					0	0	0.004482	0	0
NBPF10	100132406	broad.mit.edu	37	1	145304540	145304540	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:145304540C>T	ENST00000342960.5	+	10	1508	c.1473C>T	c.(1471-1473)tcC>tcT	p.S491S	RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369338.1_Silent_p.S220S|NBPF10_ENST00000369339.2_Silent_p.S220S	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	491										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		CTTATGACTCCAACCAGCCAC	0.458000													9	508					0	0	0.004482	0	0
CTSO	1519	broad.mit.edu	37	4	156864334	156864334	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr4:156864334G>A	ENST00000433477.3	-	2	287	c.218C>T	c.(217-219)tCc>tTc	p.S73F		NM_001334.2	NP_001325.1	P43234	CATO_HUMAN	cathepsin O	73					proteolysis	lysosome	cysteine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(3)|prostate(1)	16	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.05)|Kidney(143;0.0627)|COAD - Colon adenocarcinoma(41;0.148)		AAACAAATAGGAAAACTGATT	0.313000													5	141					0	0	0.001168	0	0
TAGAP	117289	broad.mit.edu	37	6	159457252	159457252	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:159457252C>T	ENST00000367066.3	-	10	2134	c.1803G>A	c.(1801-1803)caG>caA	p.Q601Q	TAGAP_ENST00000326965.6_Silent_p.Q423Q|RP1-111C20.4_ENST00000606466.1_RNA|RP1-111C20.4_ENST00000607796.1_RNA|RP1-111C20.4_ENST00000606470.1_RNA|RP1-111C20.4_ENST00000607391.1_RNA	NM_054114.3	NP_473455.2	Q8N103	TAGAP_HUMAN	T-cell activation RhoGTPase activating protein	601					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			NS(1)|autonomic_ganglia(1)|endometrium(3)|large_intestine(8)|lung(7)|ovary(2)|skin(1)	23		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		CTGCCGGGCCCTGCATGGCCT	0.652000													4	50					0	0	0.009096	0	0
CTRC	11330	broad.mit.edu	37	1	15770006	15770006	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:15770006C>T	ENST00000375949.4	+	5	475	c.449C>T	c.(448-450)cCc>cTc	p.P150L	CTRC_ENST00000375943.2_3'UTR|CTRC_ENST00000483406.1_3'UTR	NM_007272.2	NP_009203.2	Q99895	CTRC_HUMAN	chymotrypsin C (caldecrin)	150	Peptidase S1.				proteolysis		serine-type endopeptidase activity	p.P150R(1)		endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)	13		Breast(348;0.000207)|all_lung(284;0.00021)|Colorectal(325;0.000257)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)|Hepatocellular(190;0.0634)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCCCTGCTCCCCAAGGACTAC	0.582000													7	159					0	0	0.001984	0	0
ZNF558	148156	broad.mit.edu	37	19	8922347	8922347	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:8922347G>A	ENST00000601372.1	-	10	1530	c.819C>T	c.(817-819)ttC>ttT	p.F273F	ZNF558_ENST00000301475.1_Silent_p.F273F|ZNF558_ENST00000444186.2_Silent_p.F202F			Q96NG5	ZN558_HUMAN	zinc finger protein 558	273					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	15						ACCTTGTGCTGAAAGCTTTTC	0.458000													5	98					0	0	0.000602	0	0
CHD4	1108	broad.mit.edu	37	12	6707587	6707587	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr12:6707587G>A	ENST00000309577.6	-	11	1650	c.1487C>T	c.(1486-1488)cCa>cTa	p.P496L	CHD4_ENST00000544040.1_Missense_Mutation_p.P489L|CHD4_ENST00000544484.1_Missense_Mutation_p.P493L|CHD4_ENST00000357008.2_Missense_Mutation_p.P496L			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	496	Chromo 1.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						CTTCAGAGCTGGACACTGAGA	0.502000													9	120					0	0	0.004482	0	0
NOD2	64127	broad.mit.edu	37	16	50759472	50759472	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr16:50759472G>A	ENST00000300589.2	+	10	3060	c.2955G>A	c.(2953-2955)ttG>ttA	p.L985L		NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	985					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				ATTCAAGTTTGAAAATCCTGA	0.463000													5	101					0	0	0.000602	0	0
HK2	3099	broad.mit.edu	37	2	75115073	75115073	+	Missense_Mutation	SNP	C	C	T	rs145465326		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:75115073C>T	ENST00000290573.2	+	16	2863	c.2263C>T	c.(2263-2265)Cgt>Tgt	p.R755C	HK2_ENST00000409174.1_Missense_Mutation_p.R727C	NM_000189.4	NP_000180.2	P52789	HXK2_HUMAN	hexokinase 2	755	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	43						TGAGATTGTCCGTAACATTCT	0.478000													5	112					0	0	0.001168	0	0
ATP11C	286410	broad.mit.edu	37	X	138820208	138820208	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:138820208C>T	ENST00000370557.1	-	28	4173	c.3146G>A	c.(3145-3147)aGa>aAa	p.R1049K	ATP11C_ENST00000361648.2_Missense_Mutation_p.R1055K|ATP11C_ENST00000359686.2_Missense_Mutation_p.R1055K|ATP11C_ENST00000370543.1_Missense_Mutation_p.R1055K|ATP11C_ENST00000327569.3_Missense_Mutation_p.R1055K|ATP11C_ENST00000460773.1_5'UTR			Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C	1055					ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(31)|ovary(5)|prostate(1)|skin(3)	75	Acute lymphoblastic leukemia(192;0.000127)					AAAATACATTCTCTGTTGCTT	0.343000													8	30					0	0	0.008291	0	0
FLNB	2317	broad.mit.edu	37	3	58084612	58084612	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:58084612C>T	ENST00000357272.4	+	8	1487	c.1322C>T	c.(1321-1323)cCc>cTc	p.P441L	FLNB_ENST00000493452.1_Missense_Mutation_p.P272L|FLNB_ENST00000490882.1_Missense_Mutation_p.P441L|FLNB_ENST00000358537.3_Missense_Mutation_p.P441L|FLNB_ENST00000295956.4_Missense_Mutation_p.P441L|FLNB_ENST00000429972.2_Missense_Mutation_p.P441L|FLNB_ENST00000419752.2_Missense_Mutation_p.P272L|FLNB_ENST00000348383.5_Missense_Mutation_p.P441L			O75369	FLNB_HUMAN	filamin B, beta	441					actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CCTAAGAGTCCCTTCGTTGTG	0.547000													5	86					0	0	0.000602	0	0
LAMA4	3910	broad.mit.edu	37	6	112522853	112522853	+	Silent	SNP	A	A	G			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:112522853A>G	ENST00000230538.7	-	5	856	c.459T>C	c.(457-459)gtT>gtC	p.V153V	LAMA4_ENST00000522006.1_Silent_p.V153V|LAMA4_ENST00000524032.1_5'UTR|LAMA4_ENST00000424408.2_Silent_p.V153V|LAMA4_ENST00000389463.4_Silent_p.V153V	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	153	Laminin EGF-like 2.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		AAATGCACCGAACAGCTCCAT	0.363000													10	340					0	0	0.008291	0	0
BEST3	144453	broad.mit.edu	37	12	70049365	70049365	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr12:70049365G>A	ENST00000330891.5	-	10	1555	c.1329C>T	c.(1327-1329)ccC>ccT	p.P443P	BEST3_ENST00000331471.4_Intron|BEST3_ENST00000553096.1_Silent_p.P337P|BEST3_ENST00000488961.1_Silent_p.P230P	NM_032735.2	NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	443						chloride channel complex|plasma membrane	chloride channel activity			cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			AGGCCCTGGGGGGGTTTCTTG	0.592000													5	90					0	0	0.000602	0	0
PTCHD3	374308	broad.mit.edu	37	10	27703027	27703027	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr10:27703027C>T	ENST00000438700.3	-	1	270	c.153G>A	c.(151-153)ccG>ccA	p.P51P		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	51					spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						CGGGGGATTTCGGGGGTGCCA	0.682000													6	108					0	0	0.001984	0	0
ARID1A	8289	broad.mit.edu	37	1	27058011	27058011	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:27058011C>T	ENST00000324856.7	+	3	2090	c.1719C>T	c.(1717-1719)ctC>ctT	p.L573L	ARID1A_ENST00000374152.2_Silent_p.L190L|ARID1A_ENST00000457599.2_Silent_p.L573L	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	573					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCTCGACGCTCTCCCAGCAGG	0.632000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								6	170					0	0	0.001168	0	0
KMT2A	4297	broad.mit.edu	37	11	118376509	118376509	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr11:118376509C>T	ENST00000534358.1	+	27	9925	c.9902C>T	c.(9901-9903)cCg>cTg	p.P3301L	KMT2A_ENST00000389506.5_Missense_Mutation_p.P3298L|KMT2A_ENST00000354520.4_Missense_Mutation_p.P3260L	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		TATTTTGAACCGGCACCCCTG	0.473000													4	98					0	0	0.009096	0	0
OR2A2	442361	broad.mit.edu	37	7	143807056	143807056	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:143807056C>T	ENST00000408979.2	+	1	450	c.381C>T	c.(379-381)caC>caT	p.H127H		NM_001005480.2	NP_001005480.2	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A, member 2	127					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)|skin(4)	22	Melanoma(164;0.0783)					CCATCTGCCACCCTTTCCAGT	0.473000													5	109					0	0	0.000602	0	0
ITGA8	8516	broad.mit.edu	37	10	15760852	15760852	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr10:15760852C>T	ENST00000378076.3	-	2	609	c.256G>A	c.(256-258)Gat>Aat	p.D86N		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	86					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						TCCACGATATCGGGCTGGCTG	0.577000													4	79					0	0	0.009096	0	0
CC2D1A	54862	broad.mit.edu	37	19	14038819	14038819	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:14038819C>T	ENST00000318003.7	+	23	2671	c.2430C>T	c.(2428-2430)gaC>gaT	p.D810D	CC2D1A_ENST00000589606.1_Silent_p.D810D	NM_017721.4	NP_060191.3	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	810					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	27			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			TGGTCATTGACCCTGTGCCGG	0.657000													5	117					0	0	0.000602	0	0
CYP4F12	66002	broad.mit.edu	37	19	15791310	15791310	+	Missense_Mutation	SNP	A	A	G			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:15791310A>G	ENST00000550308.1	+	5	886	c.506A>G	c.(505-507)aAg>aGg	p.K169R	CYP4F12_ENST00000324632.9_Missense_Mutation_p.K169R	NM_023944.3	NP_076433.3			cytochrome P450, family 4, subfamily F, polypeptide 12											NS(1)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	41	Acute lymphoblastic leukemia(2;0.0367)					ATCTTCAACAAGAGTGCAAAC	0.527000													5	50					0	0	0.000602	0	0
SLC47A1	55244	broad.mit.edu	37	17	19458975	19458975	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:19458975G>A	ENST00000542886.1	+	7	699	c.613G>A	c.(613-615)Gaa>Aaa	p.E205K	SLC47A1_ENST00000457293.1_Silent_p.G237G|SLC47A1_ENST00000571335.1_Intron|SLC47A1_ENST00000436810.2_Silent_p.G214G|SLC47A1_ENST00000270570.4_Silent_p.G237G|SLC47A1_ENST00000575023.1_Intron|SLC47A1_ENST00000395585.1_Silent_p.G237G			Q96FL8	S47A1_HUMAN	solute carrier family 47 (multidrug and toxin extrusion), member 1	0						integral to membrane|plasma membrane	drug:hydrogen antiporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(5)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					ACATCCTCGGGAAAAAACTGC	0.507000													6	67					0	0	0.003080	0	0
LPA	4018	broad.mit.edu	37	6	161012037	161012037	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:161012037C>T	ENST00000447678.1	-	24	3846	c.3726G>A	c.(3724-3726)ctG>ctA	p.L1242L	LPA_ENST00000316300.5_Silent_p.L1242L	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	3750	Kringle 11.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GACATTGTGTCAGGTTGCAGT	0.507000													5	46					0	0	0.000602	0	0
NLRP4	147945	broad.mit.edu	37	19	56369305	56369305	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:56369305C>T	ENST00000301295.6	+	3	968	c.546C>T	c.(544-546)ttC>ttT	p.F182F	NLRP4_ENST00000346986.5_Silent_p.F182F|NLRP4_ENST00000587891.1_Silent_p.F107F	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	182	NACHT.						ATP binding	p.F182L(1)		breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GGGATAGGTTCCTGTACACGT	0.502000													9	123					0	0	0.006214	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187703701	187703701	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:187703701G>A	ENST00000295131.2	-	4	518	c.479C>T	c.(478-480)cCt>cTt	p.P160L		NM_182521.2	NP_872327.2	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM-type containing 2	160					apoptosis		zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(28)|ovary(2)|prostate(4)|skin(6)|urinary_tract(1)	52			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			AAAGGTGACAGGAAGCTTTTT	0.308000													7	152					0	0	0.001984	0	0
USP54	159195	broad.mit.edu	37	10	75289450	75289450	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr10:75289450G>A	ENST00000339859.4	-	14	2148	c.2048C>T	c.(2047-2049)tCa>tTa	p.S683L	USP54_ENST00000428547.1_Missense_Mutation_p.S533L|USP54_ENST00000394811.2_5'UTR|USP54_ENST00000408019.1_Missense_Mutation_p.S683L|USP54_ENST00000319786.7_Missense_Mutation_p.S683L|USP54_ENST00000497106.1_5'UTR			Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	683					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(5)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)	30	Prostate(51;0.0112)					GTAGACATTTGAGCTCTCAGG	0.527000											OREG0020266	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	182					0	0	0.002450	0	0
GIMAP8	155038	broad.mit.edu	37	7	150163851	150163851	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:150163851G>A	ENST00000307271.3	+	2	639	c.65G>A	c.(64-66)gGa>gAa	p.G22E		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	22						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		TGCCGCTCGGGAAAAAGTGCC	0.527000													4	49					0	0	0.009096	0	0
LAMB4	22798	broad.mit.edu	37	7	107748102	107748102	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:107748102C>T	ENST00000388781.3	-	6	648	c.565G>A	c.(565-567)Gat>Aat	p.D189N	LAMB4_ENST00000388780.3_Missense_Mutation_p.D189N|LAMB4_ENST00000205386.4_Missense_Mutation_p.D189N|LAMB4_ENST00000414450.2_Missense_Mutation_p.D189N	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	189	Laminin N-terminal.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						GGTTCAATATCCGAGTATTTG	0.363000													4	62					0	0	0.001168	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140720635	140720635	+	Silent	SNP	G	G	A	rs142588721		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr5:140720635G>A	ENST00000394576.2	+	1	2097	c.2097G>A	c.(2095-2097)gcG>gcA	p.A699A	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGTGGCCGCGGTCTCCTGCG	0.657000													5	164					0	0	0.000602	0	0
FLG	2312	broad.mit.edu	37	1	152277136	152277136	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:152277136C>T	ENST00000368799.1	-	3	10261	c.10226G>A	c.(10225-10227)cGa>cAa	p.R3409Q	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3409	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTTGTCTTCGTCCAGTGCT	0.602000									Ichthyosis				8	214					0	0	0.006214	0	0
LUZP4	51213	broad.mit.edu	37	X	114541098	114541098	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:114541098G>A	ENST00000371920.3	+	4	678	c.671G>A	c.(670-672)aGa>aAa	p.R224K	LUZP4_ENST00000451986.2_Missense_Mutation_p.R142K	NM_016383.3	NP_057467.1	Q9P127	LUZP4_HUMAN	leucine zipper protein 4	224						nucleus				endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	14						CACTCAGAGAGATCTCATGGT	0.473000													6	59					0	0	0.001984	0	0
ZNF778	197320	broad.mit.edu	37	16	89289675	89289675	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr16:89289675G>A	ENST00000433976.2	+	4	560	c.228G>A	c.(226-228)gaG>gaA	p.E76E	ZNF778_ENST00000306502.6_Silent_p.E6E	NM_001201407.1|NM_182531.3	NP_001188336.1|NP_872337.2	Q96MU6	ZN778_HUMAN	zinc finger protein 778	76	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|skin(2)	24				BRCA - Breast invasive adenocarcinoma(80;0.0269)		AAAACTACGAGAACCTGGCCT	0.517000													4	116					0	0	0.000602	0	0
BRAF	673	broad.mit.edu	37	7	140494231	140494231	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:140494231G>A	ENST00000288602.6	-	8	1077	c.1017C>T	c.(1015-1017)tcC>tcT	p.S339S		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	339					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	GAATTGGAATGGATTTTGAAG	0.408000		61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				9	102					0	0	0.008291	0	0
MYH8	4626	broad.mit.edu	37	17	10323365	10323365	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:10323365C>T	ENST00000403437.2	-	3	274	c.180G>A	c.(178-180)ggG>ggA	p.G60G	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	60	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						CGGTTACTTTCCCTCCTTCTT	0.423000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				9	256					0	0	0.008291	0	0
MAP3K15	389840	broad.mit.edu	37	X	19389542	19389542	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:19389542G>A	ENST00000338883.4	-	23	3214	c.3215C>T	c.(3214-3216)tCa>tTa	p.S1072L	MAP3K15_ENST00000518578.1_5'UTR|MAP3K15_ENST00000359173.3_Missense_Mutation_p.S507L|MAP3K15_ENST00000469203.2_Missense_Mutation_p.S904L	NM_001001671.3	NP_001001671.3	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase 15	1072							ATP binding|MAP kinase kinase kinase activity|metal ion binding	p.S547*(1)|p.S1119*(1)		NS(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(13)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	Hepatocellular(33;0.183)					CTTGAGCTTTGATATTGTGGT	0.527000													5	45					0	0	0.001168	0	0
KRT1	3848	broad.mit.edu	37	12	53070226	53070226	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr12:53070226G>A	ENST00000252244.3	-	7	1366	c.1308C>T	c.(1306-1308)gcC>gcT	p.A436A		NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1	436	Coil 2.|Rod.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						CATCCTTGAGGGCATTCTCGC	0.542000													4	46					0	0	0.009096	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144916680	144916680	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:144916680G>A	ENST00000529945.1	-	9	2603	c.2164C>T	c.(2164-2166)Cag>Tag	p.Q722*	PDE4DIP_ENST00000530740.1_Nonsense_Mutation_p.Q696*|PDE4DIP_ENST00000313431.9_Nonsense_Mutation_p.Q722*|PDE4DIP_ENST00000369359.4_Nonsense_Mutation_p.Q696*|PDE4DIP_ENST00000369356.4_Nonsense_Mutation_p.Q559*|PDE4DIP_ENST00000313382.9_Nonsense_Mutation_p.Q625*|PDE4DIP_ENST00000369354.3_Nonsense_Mutation_p.Q559*|PDE4DIP_ENST00000369349.3_Nonsense_Mutation_p.Q559*|PDE4DIP_ENST00000479408.2_Nonsense_Mutation_p.Q346*|PDE4DIP_ENST00000369351.3_Nonsense_Mutation_p.Q559*			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	559					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TTCAGCCACTGGAGGTTTTGA	0.438000			T	PDGFRB	MPD								7	601					0	0	0.001984	0	0
SNHG14	104472715	broad.mit.edu	37	15	25460692	25460692	+	RNA	SNP	C	C	T	rs56227008		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:25460692C>T	ENST00000424208.1	+	0	2739				SNORD115-25_ENST00000362619.1_RNA	NR_003305.1																						TGGGTTAGGTCGATTATGAGA	0.527000													13	235					0	0	0.013537	0	0
APAF1	317	broad.mit.edu	37	12	99060130	99060130	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr12:99060130C>T	ENST00000357310.1	+	9	1934	c.1357C>T	c.(1357-1359)Ctt>Ttt	p.L453F	APAF1_ENST00000549007.1_Missense_Mutation_p.L453F|APAF1_ENST00000547045.1_Missense_Mutation_p.L453F|APAF1_ENST00000551964.1_Missense_Mutation_p.L453F|APAF1_ENST00000359972.2_Missense_Mutation_p.L442F|APAF1_ENST00000552268.1_Intron|APAF1_ENST00000339433.3_Missense_Mutation_p.L453F|APAF1_ENST00000333991.1_Intron|APAF1_ENST00000550527.1_Missense_Mutation_p.L442F	NM_181868.1	NP_863658.1	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1	453					activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(1)	42					Adenosine triphosphate(DB00171)	TTGCAGCCAGCTTCAGGTACT	0.294000													5	67					0	0	0.001984	0	0
HHATL	57467	broad.mit.edu	37	3	42740367	42740367	+	Missense_Mutation	SNP	C	C	T	rs148287985		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:42740367C>T	ENST00000441594.1	-	5	577	c.316G>A	c.(316-318)Ggg>Agg	p.G106R	HHATL_ENST00000310417.5_Missense_Mutation_p.G106R	NM_020707.3	NP_065758.3	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	106					negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(3)|prostate(3)	19				KIRC - Kidney renal clear cell carcinoma(284;0.215)		GCCAAGGCCCCGTACACAGCA	0.612000													4	72					0	0	0.001168	0	0
GBF1	8729	broad.mit.edu	37	10	104120832	104120832	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr10:104120832C>T	ENST00000369983.3	+	13	1703	c.1443C>T	c.(1441-1443)ttC>ttT	p.F481F	GBF1_ENST00000476019.1_3'UTR	NM_001199378.1|NM_001199379.1|NM_004193.2	NP_001186307.1|NP_001186308.1|NP_004184.1	Q92538	GBF1_HUMAN	golgi brefeldin A resistant guanine nucleotide exchange factor 1	481					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(14)|kidney(8)|large_intestine(15)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	71		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		GAGTATGCTTCCTACTGTTTG	0.428000													8	108					0	0	0.004482	0	0
NLRP4	147945	broad.mit.edu	37	19	56370010	56370010	+	Missense_Mutation	SNP	C	C	G			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:56370010C>G	ENST00000301295.6	+	3	1673	c.1251C>G	c.(1249-1251)gaC>gaG	p.D417E	NLRP4_ENST00000346986.5_Missense_Mutation_p.D417E|NLRP4_ENST00000587891.1_Missense_Mutation_p.D342E	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	417	NACHT.						ATP binding	p.D417D(1)		breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TTTGTGAAGACGACCTCCGGA	0.587000													6	110					0	0	0.001984	0	0
ADGRG6	57211	broad.mit.edu	37	6	142711423	142711423	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:142711423G>A	ENST00000230173.6	+	7	1727	c.1251G>A	c.(1249-1251)gtG>gtA	p.V417V	GPR126_ENST00000296932.8_Silent_p.V389V|GPR126_ENST00000367608.2_Silent_p.V389V|GPR126_ENST00000367609.3_Silent_p.V417V	NM_020455.5	NP_065188.4	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126	417					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(1)|kidney(3)|large_intestine(12)|lung(10)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		TATCCGTAGTGATTCAGAACA	0.308000													5	78					0	0	0.001984	0	0
KIAA1407	57577	broad.mit.edu	37	3	113684045	113684045	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:113684045G>A	ENST00000295878.3	-	17	2914	c.2768C>T	c.(2767-2769)tCa>tTa	p.S923L		NM_020817.1	NP_065868.1	Q8NCU4	K1407_HUMAN	KIAA1407	923								p.S923L(1)		endometrium(9)|large_intestine(7)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	40						CCAAGTATCTGATTGCTGATA	0.428000													5	86					0	0	0.001168	0	0
CCR4	1233	broad.mit.edu	37	3	32995532	32995532	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:32995532C>T	ENST00000330953.5	+	2	786	c.618C>T	c.(616-618)atC>atT	p.I206I		NM_005508.4	NP_005499.1	P51679	CCR4_HUMAN	chemokine (C-C motif) receptor 4	206					chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response	integral to plasma membrane				NS(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)|stomach(1)	16						CCCTGGAAATCAACATTCTCG	0.453000													7	135					0	0	0.003080	0	0
INADL	10207	broad.mit.edu	37	1	62330222	62330222	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:62330222C>T	ENST00000371158.2	+	20	2866	c.2752C>T	c.(2752-2754)Cca>Tca	p.P918S	INADL_ENST00000316485.6_Missense_Mutation_p.P918S	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	918					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TGATAATGAACCATCCGAGTC	0.483000													4	95					0	0	0.009096	0	0
ENTPD2	954	broad.mit.edu	37	9	139945549	139945549	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr9:139945549C>T	ENST00000355097.2	-	5	626	c.579G>A	c.(577-579)cgG>cgA	p.R193R	ENTPD2_ENST00000312665.5_Silent_p.R193R	NM_001246.3|NM_203468.2	NP_001237.1|NP_982293.1	Q9Y5L3	ENTP2_HUMAN	ectonucleoside triphosphate diphosphohydrolase 2	193						integral to membrane	ATP binding			endometrium(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(3)	12	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GTGTCCCCTTCCGTGGCCGGA	0.677000													5	56					0	0	0.001984	0	0
REG4	83998	broad.mit.edu	37	1	120337285	120337285	+	Missense_Mutation	SNP	C	C	T	rs150927973		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:120337285C>T	ENST00000354219.1	-	7	872	c.433G>A	c.(433-435)Gaa>Aaa	p.E145K	REG4_ENST00000530654.1_3'UTR|REG4_ENST00000256585.5_Missense_Mutation_p.E145K	NM_001159352.1	NP_001152824.1	Q9BYZ8	REG4_HUMAN	regenerating islet-derived family, member 4	145	C-type lectin.					extracellular region	sugar binding	p.E145K(2)		central_nervous_system(1)|large_intestine(1)|lung(8)|ovary(2)|prostate(1)|skin(2)	15	all_cancers(5;4.81e-10)|all_epithelial(5;7.98e-11)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;8.1e-07)|Lung NSC(69;5.89e-06)|all_epithelial(167;0.000959)		Lung(183;0.011)|LUSC - Lung squamous cell carcinoma(189;0.0588)		TTGTTGCATTCGTTGCTGCTC	0.423000													26	416					0	0	0.007291	0	0
FLG	2312	broad.mit.edu	37	1	152276739	152276739	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:152276739C>T	ENST00000368799.1	-	3	10658	c.10623G>A	c.(10621-10623)caG>caA	p.Q3541Q	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3541	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCACTGTCCTGGCTAACAC	0.572000									Ichthyosis				6	241					0	0	0.004482	0	0
CHRNA3	1136	broad.mit.edu	37	15	78885499	78885499	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:78885499C>T	ENST00000348639.3	-	6	1924	c.1424G>A	c.(1423-1425)cGa>cAa	p.R475Q	CHRNA5_ENST00000559554.1_3'UTR|CHRNA5_ENST00000299565.5_Silent_p.F437F	NM_001166694.1	NP_001160166.1	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3 (neuronal)	0					activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CTTTTCTTTTCGTTTCAATTG	0.318000													7	78					0	0	0.003080	0	0
ZC3H13	23091	broad.mit.edu	37	13	46559584	46559584	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr13:46559584G>A	ENST00000242848.4	-	10	1916	c.1568C>T	c.(1567-1569)cCa>cTa	p.P523L	ZC3H13_ENST00000282007.3_Missense_Mutation_p.P523L			Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	523	Arg/Ser-rich.						nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		GGATTCTTCTGGATATGTATC	0.463000													5	84					0	0	0.001168	0	0
PGA5	5222	broad.mit.edu	37	11	61015892	61015892	+	Missense_Mutation	SNP	G	G	A	rs147049038	byFrequency	TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr11:61015892G>A	ENST00000451616.2	+	1	299	c.196G>A	c.(196-198)Gat>Aat	p.D66N	CTD-2331C18.5_ENST00000537594.1_RNA|PGA4_ENST00000422676.2_Splice_Site_p.D220_splice|PGA5_ENST00000312403.5_Splice_Site_p.D220_splice			P00790	PEPA_HUMAN	pepsinogen 5, group I (pepsinogen A)	220					digestion|proteolysis	extracellular region	aspartic-type endopeptidase activity			large_intestine(1)|skin(1)	2						TTTCCACAGCGATGACAAGAG	0.498000													10	373					0	0	0.010729	0	0
DNAH9	1770	broad.mit.edu	37	17	11687853	11687853	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:11687853C>T	ENST00000262442.3	+	41	8126	c.8058C>T	c.(8056-8058)ttC>ttT	p.F2686F	DNAH9_ENST00000454412.2_Silent_p.F2686F	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2686	AAA 3 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CCAACATTTTCCAGGTGAGTT	0.468000													4	122					0	0	0.001168	0	0
PRSS35	167681	broad.mit.edu	37	6	84234001	84234001	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:84234001G>A	ENST00000536636.1	+	3	1186	c.841G>A	c.(841-843)Gag>Aag	p.E281K	PRSS35_ENST00000369700.3_Missense_Mutation_p.E281K	NM_001170423.1	NP_001163894.1	Q8N3Z0	PRS35_HUMAN	protease, serine, 35	281	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(2)|large_intestine(12)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	32		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)		TGCTCTTCTGGAGCTGAAGCG	0.493000													4	57					0	0	0.009096	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84605862	84605862	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr9:84605862G>A	ENST00000344803.2	+	4	524	c.477G>A	c.(475-477)ttG>ttA	p.L159L		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		TGTCCCCTTTGGCTTCTTCGG	0.567000													5	48					0	0	0.001168	0	0
SELE	6401	broad.mit.edu	37	1	169697306	169697306	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:169697306C>T	ENST00000333360.7	-	8	1311	c.1172G>A	c.(1171-1173)gGg>gAg	p.G391E	C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367781.4_Intron|SELE_ENST00000367775.1_Intron|SELE_ENST00000367782.4_Missense_Mutation_p.G391E|SELE_ENST00000367776.1_Intron|SELE_ENST00000367777.1_Missense_Mutation_p.G391E|SELE_ENST00000367780.4_Intron|SELE_ENST00000367774.1_Intron|SELE_ENST00000367779.4_Intron	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	391	Sushi 4.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					ACAGCTGGACCCATAACGGAA	0.527000													4	107					0	0	0.009096	0	0
PMEL	6490	broad.mit.edu	37	12	56349077	56349077	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr12:56349077G>A	ENST00000548747.1	-	10	2493	c.1831C>T	c.(1831-1833)Ctt>Ttt	p.L611F	PMEL_ENST00000360714.4_Missense_Mutation_p.L618F|PMEL_ENST00000449260.2_Missense_Mutation_p.L618F|PMEL_ENST00000539511.1_Missense_Mutation_p.L525F|PMEL_ENST00000548493.1_Missense_Mutation_p.L611F|PMEL_ENST00000536427.1_Missense_Mutation_p.L576F|PMEL_ENST00000550464.1_Missense_Mutation_p.L525F|PMEL_ENST00000552882.1_Missense_Mutation_p.L611F|PMEL_ENST00000550447.1_Missense_Mutation_p.L240F			P40967	PMEL_HUMAN	premelanosome protein	611					melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding			NS(1)|breast(2)|endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						AGAGATGCAAGGACCACAGCC	0.512000													6	148					0	0	0.004482	0	0
CFAP54	144535	broad.mit.edu	37	12	97158976	97158976	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr12:97158976C>T	ENST00000524981.3	+	27	3614	c.3614C>T	c.(3613-3615)tCg>tTg	p.S1205L				Q6ZTY8	CL063_HUMAN		1179										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						CTTTTGTCTTCGTATACAGAT	0.289000													4	50					0	0	0.009096	0	0
MUC16	94025	broad.mit.edu	37	19	9090172	9090172	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:9090172G>A	ENST00000397910.4	-	1	1846	c.1643C>T	c.(1642-1644)cCc>cTc	p.P548L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	548	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGATGCTGGGGGTCTCTCTGT	0.522000													4	62					0	0	0.000602	0	0
RP11-24M17.5	0	broad.mit.edu	37	15	76075237	76075237	+	RNA	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr15:76075237G>A	ENST00000395215.3	+	0	877																											AACACCTGAGGAAGGAGGTGG	0.547000													4	39					0	0	0.009096	0	0
ACE	1636	broad.mit.edu	37	17	61560517	61560517	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr17:61560517C>T	ENST00000290866.4	+	9	1494	c.1470C>T	c.(1468-1470)ttC>ttT	p.F490F	ACE_ENST00000584529.1_Intron|ACE_ENST00000538928.1_Intron|ACE_ENST00000428043.1_Silent_p.F490F	NM_000789.3	NP_000780.1	P12821	ACE_HUMAN	angiotensin I converting enzyme	490	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GCTACAACTTCGACTGGTGGT	0.617000													12	196					0	0	0.002450	0	0
ESRRG	2104	broad.mit.edu	37	1	216680424	216680424	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:216680424G>A	ENST00000391890.3	-	9	1703	c.1186C>T	c.(1186-1188)Cgt>Tgt	p.R396C	ESRRG_ENST00000361525.3_Missense_Mutation_p.R389C|ESRRG_ENST00000360012.3_Missense_Mutation_p.R389C|ESRRG_ENST00000366937.1_Missense_Mutation_p.R424C|ESRRG_ENST00000493603.1_Missense_Mutation_p.R389C|ESRRG_ENST00000463665.1_Missense_Mutation_p.R350C|ESRRG_ENST00000408911.3_Missense_Mutation_p.R412C|ESRRG_ENST00000361395.2_Missense_Mutation_p.R389C|ESRRG_ENST00000487276.1_Missense_Mutation_p.R389C|ESRRG_ENST00000359162.2_Missense_Mutation_p.R389C|ESRRG_ENST00000366938.2_Missense_Mutation_p.R389C|ESRRG_ENST00000493748.1_Missense_Mutation_p.R389C|ESRRG_ENST00000366940.2_Missense_Mutation_p.R389C	NM_001243515.1|NM_001243519.1	NP_001230444.1|NP_001230448.1	P62508	ERR3_HUMAN	estrogen-related receptor gamma	412					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(8)|liver(1)|lung(29)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	CCAGCTCGACGAGGGTCTTCC	0.512000													5	76					0	0	0.000602	0	0
UGT1A6	54578	broad.mit.edu	37	2	234602330	234602330	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:234602330C>T	ENST00000305139.6	+	1	819	c.680C>T	c.(679-681)tCa>tTa	p.S227L	UGT1A8_ENST00000373450.4_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A10_ENST00000344644.5_Intron|AC114812.8_ENST00000439336.1_RNA|UGT1A6_ENST00000480628.1_Intron	NM_001072.3	NP_001063.2														central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|skin(1)|upper_aerodigestive_tract(1)	22		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;5.86e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000384)|Lung(119;0.00306)|LUSC - Lung squamous cell carcinoma(224;0.00702)		TGTCTGTTTTCAAAGTATGAA	0.393000													6	151					0	0	0.001168	0	0
CELA2A	63036	broad.mit.edu	37	1	15789236	15789236	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:15789236G>A	ENST00000359621.4	+	4	261	c.236G>A	c.(235-237)aGg>aAg	p.R79K		NM_033440.2	NP_254275.1	P08217	CEL2A_HUMAN	chymotrypsin-like elastase family, member 2A	79	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(2)|prostate(1)	16						AGCTCCTCCAGGACCTACCGC	0.617000													6	92					0	0	0.001984	0	0
CPOX	1371	broad.mit.edu	37	3	98304426	98304426	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:98304426G>A	ENST00000264193.2	-	5	1249	c.1031C>T	c.(1030-1032)tCt>tTt	p.S344F		NM_000097.5	NP_000088.3	P36551	HEM6_HUMAN	coproporphyrinogen oxidase	344						mitochondrial intermembrane space	coproporphyrinogen oxidase activity|protein homodimerization activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)	16						CTTGGACGGAGAGTCAAGATC	0.483000													8	122					0	0	0.003080	0	0
EPPIN	57119	broad.mit.edu	37	20	44174424	44174424	+	Missense_Mutation	SNP	G	G	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr20:44174424G>T	ENST00000336443.3	-	1	592	c.29C>A	c.(28-30)aCc>aAc	p.T10N	EPPIN_ENST00000354280.4_Intron|EPPIN-WFDC6_ENST00000504988.1_Intron|EPPIN_ENST00000409554.1_Intron|EPPIN_ENST00000555685.1_Intron					epididymal peptidase inhibitor																		GGAAAGAGCGGTTTTACACCC	0.468000													5	65					0.00198382	0.0021672	0.001984	1	0
GRIN2A	2903	broad.mit.edu	37	16	9862744	9862744	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr16:9862744G>A	ENST00000396573.2	-	13	2868	c.2559C>T	c.(2557-2559)tgC>tgT	p.C853C	GRIN2A_ENST00000562109.1_Silent_p.C853C|GRIN2A_ENST00000404927.2_Silent_p.C853C|GRIN2A_ENST00000535259.1_Silent_p.C696C|GRIN2A_ENST00000330684.3_Silent_p.C853C|GRIN2A_ENST00000396575.2_Silent_p.C853C	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	853					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GCCGGTCGGAGCACACGCCCG	0.557000													6	114					0	0	0.001984	0	0
ABCC8	6833	broad.mit.edu	37	11	17485033	17485033	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr11:17485033G>A	ENST00000302539.4	-	4	656	c.531C>T	c.(529-531)atC>atT	p.I177I	ABCC8_ENST00000389817.3_Silent_p.I177I	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	177					carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	TCCCATAGAGGATCACCAGCA	0.597000													14	422					0	0	0.004990	0	0
EFHC1	114327	broad.mit.edu	37	6	52317573	52317573	+	Missense_Mutation	SNP	C	C	T	rs139197513		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr6:52317573C>T	ENST00000371068.5	+	4	764	c.661C>T	c.(661-663)Cgt>Tgt	p.R221C	EFHC1_ENST00000538167.1_Missense_Mutation_p.R202C|EFHC1_ENST00000433625.2_Missense_Mutation_p.R130C	NM_018100.3	NP_060570.2	Q5JVL4	EFHC1_HUMAN	EF-hand domain (C-terminal) containing 1	221			R -> H (in EJM1; associated with T-77; reduces substantially the cell death effect; reduces partly the calcium influx; binds to CACNA1E).			axoneme|neuronal cell body	calcium ion binding|protein C-terminus binding			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(8)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	27	Lung NSC(77;0.109)					ACAGCCTCTTCGTAAGTATGT	0.383000													6	88					0	0	0.001168	0	0
DNAH5	1767	broad.mit.edu	37	5	13793818	13793818	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr5:13793818C>T	ENST00000265104.4	-	49	8134	c.8030G>A	c.(8029-8031)cGa>cAa	p.R2677Q		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2677	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CATCAGCTGTCGCACTATCTC	0.438000									Kartagener syndrome				5	84					0	0	0.000602	0	0
RFPL1	5988	broad.mit.edu	37	22	29835128	29835128	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr22:29835128G>A	ENST00000354373.2	+	1	557	c.348G>A	c.(346-348)atG>atA	p.M116I	RFPL1S_ENST00000461286.2_RNA	NM_021026.2	NP_066306.2	O75677	RFPL1_HUMAN	ret finger protein-like 1	116	B30.2/SPRY.						zinc ion binding			endometrium(3)|large_intestine(1)|lung(6)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	16						TTCTGCAGATGAACCCAAGGA	0.517000													5	91					0	0	0.001168	0	0
UNC13A	23025	broad.mit.edu	37	19	17759387	17759387	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:17759387C>T	ENST00000428389.2	-	17	1932	c.1933G>A	c.(1933-1935)Gaa>Aaa	p.E645K	UNC13A_ENST00000552293.1_Missense_Mutation_p.E557K|UNC13A_ENST00000551649.1_Missense_Mutation_p.E557K|UNC13A_ENST00000550896.1_Missense_Mutation_p.E555K|UNC13A_ENST00000519716.2_Missense_Mutation_p.E557K|UNC13A_ENST00000252773.7_Missense_Mutation_p.E557K			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	557					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						GTCCACACTTCGAAGTTGTGT	0.607000													4	65					0	0	0.001168	0	0
TRANK1	9881	broad.mit.edu	37	3	36898710	36898710	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:36898710C>T	ENST00000429976.2	-	12	2618	c.2371G>A	c.(2371-2373)Gag>Aag	p.E791K	TRANK1_ENST00000428977.2_Missense_Mutation_p.E241K|TRANK1_ENST00000301807.6_Missense_Mutation_p.E241K			O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	791					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						CACTCGATCTCCCAGGTCATG	0.493000													12	249					0	0	0.013537	0	0
MUC16	94025	broad.mit.edu	37	19	9003659	9003659	+	Silent	SNP	G	G	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:9003659G>T	ENST00000397910.4	-	49	40184	c.39981C>A	c.(39979-39981)ctC>ctA	p.L13327L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13329	SEA 9.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.L12L(1)|p.L13327L(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGTAAAATTGAGGGTGAATG	0.473000													5	153					1.23904e-05	1.36504e-05	0.000602	1	0
PDE1C	5137	broad.mit.edu	37	7	31918640	31918640	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:31918640G>A	ENST00000396184.3	-	5	598	c.394C>T	c.(394-396)Cac>Tac	p.H132Y	PDE1C_ENST00000321453.7_Missense_Mutation_p.H132Y|PDE1C_ENST00000396182.2_Missense_Mutation_p.H132Y|PDE1C_ENST00000396193.1_Missense_Mutation_p.H192Y|PDE1C_ENST00000396191.1_Missense_Mutation_p.H132Y	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	132					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			TGCACTGCGTGAACGATGCTC	0.527000													6	98					0	0	0.001984	0	0
TIE1	7075	broad.mit.edu	37	1	43777469	43777469	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:43777469G>A	ENST00000372476.3	+	10	1540	c.1461G>A	c.(1459-1461)caG>caA	p.Q487Q	TIE1_ENST00000433781.2_Silent_p.Q132Q	NM_001253357.1|NM_005424.4	NP_001240286.1|NP_005415.1	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	487	Fibronectin type-III 1.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				ACCGGCCCCAGGACAGTACCA	0.607000													5	80					0	0	0.001168	0	0
HIPK4	147746	broad.mit.edu	37	19	40895647	40895647	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:40895647C>T	ENST00000291823.2	-	1	447	c.163G>A	c.(163-165)Gag>Aag	p.E55K		NM_144685.3	NP_653286.2	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	55	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	20			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			AGCTTCAGCTCGTTCTTGATG	0.592000													5	148					0	0	0.000602	0	0
KLK12	43849	broad.mit.edu	37	19	51534106	51534106	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:51534106G>A	ENST00000250352.11	-	4	872	c.199C>T	c.(199-201)Ccc>Tcc	p.P67S	CTC-518B2.9_ENST00000594910.1_RNA|KLK12_ENST00000319590.4_Missense_Mutation_p.P177S|KLK12_ENST00000250351.4_Missense_Mutation_p.P177S|KLK12_ENST00000529888.1_Missense_Mutation_p.S90F|KLK12_ENST00000525263.1_Missense_Mutation_p.P177S			Q9UKR0	KLK12_HUMAN	kallikrein-related peptidase 12	177	Peptidase S1.				proteolysis	extracellular region|soluble fraction	serine-type endopeptidase activity			endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	12		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00399)		ATTCTCCCGGGATACACACCA	0.627000													7	154					0	0	0.006214	0	0
WDR47	22911	broad.mit.edu	37	1	109524385	109524385	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:109524385G>A	ENST00000357672.3	-	12	2659	c.2284C>T	c.(2284-2286)Cgt>Tgt	p.R762C	WDR47_ENST00000369962.3_Missense_Mutation_p.R790C|WDR47_ENST00000361054.3_Missense_Mutation_p.R762C|WDR47_ENST00000369965.4_Missense_Mutation_p.R791C|WDR47_ENST00000400794.3_Missense_Mutation_p.R798C			O94967	WDR47_HUMAN	WD repeat domain 47	790										breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		CCAACAACACGAACACAACTT	0.373000													8	253					0	0	0.004482	0	0
KLHL23	151230	broad.mit.edu	37	2	170592502	170592502	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr2:170592502G>A	ENST00000392647.2	+	2	1222	c.978G>A	c.(976-978)ggG>ggA	p.G326G	KLHL23_ENST00000602521.1_Intron|KLHL23_ENST00000272797.4_Silent_p.G326G	NM_144711.5	NP_653312.2	Q8NBE8	KLH23_HUMAN	kelch-like family member 23	326										breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(4)|skin(1)|urinary_tract(1)	16						ATGTAACTGGGGGCTACAGGA	0.428000													4	146					0	0	0.009096	0	0
KIAA2022	340533	broad.mit.edu	37	X	73964093	73964093	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chrX:73964093G>A	ENST00000373468.1	-	3	950	c.299C>T	c.(298-300)tCc>tTc	p.S100F	KIAA2022_ENST00000055682.5_Missense_Mutation_p.S100F			Q5QGS0	K2022_HUMAN	KIAA2022	100					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						AGATGTGAGGGAGATGGCATT	0.512000													4	49					0	0	0.009096	0	0
CYP4F8	11283	broad.mit.edu	37	19	15728897	15728897	+	RNA	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr19:15728897C>T	ENST00000441682.2	+	0	349							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						TGGGCCCCATCACTCCCATCA	0.582000													5	111					0	0	0.000602	0	0
SHCBP1L	81626	broad.mit.edu	37	1	182874684	182874684	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:182874684C>T	ENST00000367547.3	-	7	1519	c.1283G>A	c.(1282-1284)gGa>gAa	p.G428E	SHCBP1L_ENST00000423786.1_Missense_Mutation_p.G309E|SHCBP1L_ENST00000488956.1_5'UTR	NM_030933.2	NP_112195.2	Q9BZQ2	SHP1L_HUMAN	SHC SH2-domain binding protein 1-like	500										breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|pancreas(1)|prostate(1)|skin(2)	15						TTGATATTCTCCTGGAAAAAT	0.353000													4	44					0	0	0.009096	0	0
MUC17	140453	broad.mit.edu	37	7	100685192	100685192	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:100685192C>T	ENST00000306151.4	+	3	10559	c.10495C>T	c.(10495-10497)Cct>Tct	p.P3499S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3499	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CAATTCATCTCCTACAACTGC	0.517000													12	238					0	0	0.013537	0	0
SEMA5A	9037	broad.mit.edu	37	5	9044571	9044571	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr5:9044571G>A	ENST00000382496.5	-	22	3684	c.3019C>T	c.(3019-3021)Cac>Tac	p.H1007Y	CTD-2215L10.1_ENST00000506519.1_RNA	NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	1007					cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						GAGACGGGGTGGATGACAGTC	0.552000													4	90					0	0	0.000602	0	0
TNN	63923	broad.mit.edu	37	1	175113579	175113579	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:175113579G>A	ENST00000239462.4	+	18	3765	c.3652G>A	c.(3652-3654)Gat>Aat	p.D1218N		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	1218	Fibrinogen C-terminal.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CAGAGACAATGATATCGCACT	0.512000													5	89					0	0	0.001168	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77465432	77465432	+	Silent	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr16:77465432C>T	ENST00000282849.5	-	3	673	c.255G>A	c.(253-255)agG>agA	p.R85R	ADAMTS18_ENST00000567121.1_5'UTR	NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	85					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						ATCGCTTTTTCCTGCCGTTGT	0.478000													6	287					0	0	0.001984	0	0
LTF	4057	broad.mit.edu	37	3	46479551	46479551	+	Missense_Mutation	SNP	G	G	A	rs148227142		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:46479551G>A	ENST00000231751.4	-	16	2273	c.1978C>T	c.(1978-1980)Ctt>Ttt	p.L660F	LTF_ENST00000417439.1_Missense_Mutation_p.L658F|LTF_ENST00000426532.2_Missense_Mutation_p.L616F|LTF_ENST00000493056.1_5'UTR	NM_002343.3	NP_002334.2	P02788	TRFL_HUMAN	lactotransferrin	660	Transferrin-like 2.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	40				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	TTGAACAGAAGGTTTTTGGTT	0.433000													10	165					0	0	0.010729	0	0
POMGNT2	84892	broad.mit.edu	37	3	43122071	43122071	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:43122071C>T	ENST00000344697.2	-	2	1198	c.853G>A	c.(853-855)Ggc>Agc	p.G285S	GTDC2_ENST00000441964.1_Missense_Mutation_p.G285S	NM_032806.4	NP_116195.2																					TACTCCTCGCCTAGGGGGACT	0.557000													4	78					0	0	0.009096	0	0
EMILIN2	84034	broad.mit.edu	37	18	2892287	2892287	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr18:2892287G>A	ENST00000254528.3	+	4	2321	c.2162G>A	c.(2161-2163)gGa>gAa	p.G721E		NM_032048.2	NP_114437.2	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2	721					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding	p.G721E(1)		breast(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(4)	48				READ - Rectum adenocarcinoma(2;0.1)		TCTATCTCAGGAAATCTTCAG	0.542000													4	90					0	0	0.009096	0	0
SHANK3	85358	broad.mit.edu	37	22	51159572	51159572	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr22:51159572C>T	ENST00000414786.2	+	21	3496	c.3269C>T	c.(3268-3270)cCc>cTc	p.P1090L	SHANK3_ENST00000445220.2_Missense_Mutation_p.P1106L|SHANK3_ENST00000262795.3_Missense_Mutation_p.P1120L			F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	1120										central_nervous_system(1)|endometrium(1)|kidney(1)|lung(5)	8		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		CCCCTGGACCCCAGCTCACCC	0.726000													4	11					0	0	0.000602	0	0
KCNA10	3744	broad.mit.edu	37	1	111059896	111059896	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:111059896G>A	ENST00000369771.2	-	1	1901	c.1514C>T	c.(1513-1515)tCc>tTc	p.S505F		NM_005549.2	NP_005540.1	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 10	505						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(3)|skin(1)|urinary_tract(1)	35		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		CTTCTCTGTGGAACAGCCACC	0.478000													6	92					0	0	0.003080	0	0
CPB1	1360	broad.mit.edu	37	3	148563342	148563342	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr3:148563342C>T	ENST00000491148.1	+	10	1244	c.910C>T	c.(910-912)Cac>Tac	p.H304Y	CPB1_ENST00000282957.4_Missense_Mutation_p.H304Y			P15086	CBPB1_HUMAN	carboxypeptidase B1 (tissue)	304					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	38			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			TCTGACAATCCACTCGTACTC	0.448000													7	70					0	0	0.001984	0	0
ABCC6	368	broad.mit.edu	37	16	16284039	16284039	+	Silent	SNP	G	G	A			TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr16:16284039G>A	ENST00000205557.7	-	12	1646	c.1617C>T	c.(1615-1617)ttC>ttT	p.F539F	ABCC6_ENST00000574094.1_5'UTR	NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	539	ABC transmembrane type-1 1.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		TAGACACTTGGAAGGACACCA	0.632000													4	87					0	0	0.009096	0	0
UBXN11	91544	broad.mit.edu	37	1	26608878	26608883	+	In_Frame_Del	DEL	CCGGGA	CCGGGA	-	rs1134580		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr1:26608878_26608883delCCGGGA	ENST00000314675.7	-	11	1189_1194	c.1110_1115delTCCCGG	c.(1108-1116)ggc>gg	p.GPG370del	UBXN11_ENST00000374222.1_In_Frame_Del_p.GPG490del|UBXN11_ENST00000374221.3_In_Frame_Del_p.GPG490del|UBXN11_ENST00000357089.4_In_Frame_Del_p.GPG457del|UBXN11_ENST00000374223.1_In_Frame_Del_p.GPG247del|UBXN11_ENST00000374217.2_In_Frame_Del_p.GPG457del	NM_001077262.1	NP_001070730.1	Q5T124	UBX11_HUMAN	UBX domain protein 11	490						cytoplasm|cytoskeleton		p.G490_P515delGPGPSPGPGPGPSPGPGPGPSPCPGP(1)		endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(3)	23						gggactggggccgggaccgggaccgg	0.718													7	38	---	---	---	---					
SSPO	23145	broad.mit.edu	37	7	149515189	149515189	+	RNA	DEL	A	A	-	rs112122477		TCGA-ER-A19A-06A-21D-A197-08	TCGA-ER-A19A-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53983b06-67c9-4a3d-bd9e-08638e257a95	7e84ded3-0af1-4d76-95db-479d5f5a23e3	g.chr7:149515189delA	ENST00000378016.2	+	0	11577							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GACCTCGAGTAACTGCCCCAG	0.667													10	10	---	---	---	---