Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MAGEC3	139081	broad.mit.edu	37	X	140953275	140953275	+	Missense_Mutation	SNP	G	G	T			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chrX:140953275G>T	ENST00000298296.1	+	2	142	c.142G>T	c.(142-144)Gat>Tat	p.D48Y		NM_138702.1	NP_619647.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	48										NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					AAAGGCCACAGATAAGGACTA	0.493000													12	35					0.00185496	0.00210229	1	1	0
IFNA16	3449	broad.mit.edu	37	9	21216993	21216993	+	Silent	SNP	G	G	T			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr9:21216993G>T	ENST00000380216.1	-	1	317	c.312C>A	c.(310-312)ctC>ctA	p.L104L		NM_002173.2	NP_002164.1	P05015	IFN16_HUMAN	interferon, alpha 16	104					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	13				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		ATTTGTCTAGGAGGGTCTCAT	0.483000													20	63					6.33239e-15	7.68933e-15	1	1	0
F8	2157	broad.mit.edu	37	X	154221393	154221393	+	Missense_Mutation	SNP	C	C	A			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chrX:154221393C>A	ENST00000360256.4	-	4	619	c.419G>T	c.(418-420)aGg>aTg	p.R140M		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	140	F5/8 type A 1.|Plastocyanin-like 1.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TTCTTTCTCCCTTTGACTGGT	0.418000													8	110					0.000157383	0.000184518	1	1	0
NDST4	64579	broad.mit.edu	37	4	115767006	115767006	+	Silent	SNP	G	G	A			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr4:115767006G>A	ENST00000264363.2	-	10	2766	c.2088C>T	c.(2086-2088)ccC>ccT	p.P696P		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	696	Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		CCCTGTCTGAGGGGTCAATGA	0.423000													15	31					0	0	1	0	0
PTCH2	8643	broad.mit.edu	37	1	45294274	45294274	+	Silent	SNP	C	C	T			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr1:45294274C>T	ENST00000447098.2	-	12	1505	c.1494G>A	c.(1492-1494)acG>acA	p.T498T	PTCH2_ENST00000372192.3_Silent_p.T498T	NM_001166292.1	NP_001159764.1	Q9Y6C5	PTC2_HUMAN	patched 2	498	SSD.				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	50	Acute lymphoblastic leukemia(166;0.155)					CACTGGTGCCCGTGCGCTGCA	0.627000									Basal Cell Nevus syndrome				6	17					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29625875	29625875	+	Missense_Mutation	SNP	T	T	C	rs143761036	by1000genomes	TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr20:29625875T>C	ENST00000278882.3	+	5	499	c.119T>C	c.(118-120)aTc>aCc	p.I40T	FRG1B_ENST00000358464.4_Missense_Mutation_p.I40T|FRG1B_ENST00000439954.2_Missense_Mutation_p.I45T														p.I40T(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGTACAGAATCGCCCTGAAA	0.358000													3	45					0	0	1	0	0
ACSF3	197322	broad.mit.edu	37	16	89180886	89180886	+	Missense_Mutation	SNP	C	C	T	rs144907664		TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr16:89180886C>T	ENST00000317447.4	+	6	1494	c.1117C>T	c.(1117-1119)Cgc>Tgc	p.R373C	ACSF3_ENST00000406948.3_Missense_Mutation_p.R373C|ACSF3_ENST00000378345.4_Missense_Mutation_p.R108C|CTD-2555A7.3_ENST00000562782.1_RNA	NM_001127214.2|NM_001243279.1|NM_174917.3	NP_001120686.1|NP_001230208.1|NP_777577.2	Q4G176	ACSF3_HUMAN	acyl-CoA synthetase family member 3	373					fatty acid metabolic process	mitochondrion	acid-thiol ligase activity|ATP binding			central_nervous_system(1)|endometrium(1)|kidney(2)|lung(9)|prostate(1)|urinary_tract(1)	15				BRCA - Breast invasive adenocarcinoma(80;0.0281)		CACTGCCGTGCGCCTGCCAGG	0.632000													8	49					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152490209	152490209	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr2:152490209C>T	ENST00000397345.3	-	65	9575	c.9373G>A	c.(9373-9375)Gat>Aat	p.D3125N	NEB_ENST00000172853.10_Intron|NEB_ENST00000604864.1_Missense_Mutation_p.D3125N|NEB_ENST00000409198.1_Intron|NEB_ENST00000603639.1_Missense_Mutation_p.D3125N|NEB_ENST00000427231.2_Missense_Mutation_p.D3125N	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	3125					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TGGATGACATCGCTCTGGTCA	0.493000													28	68					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	14063135	14063135	+	RNA	SNP	G	G	A			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr11:14063135G>A	ENST00000310358.7	+	0	951							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		AGCACTCCACGGAGGAGGACC	0.468000													26	49					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262696	140262696	+	Silent	SNP	T	T	C			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr5:140262696T>C	ENST00000289272.2	+	1	843	c.843T>C	c.(841-843)ttT>ttC	p.F281F	PCDHA4_ENST00000530339.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA13_ENST00000409494.1_Silent_p.F281F|PCDHA11_ENST00000398640.2_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTACTCATTTAGAAGGCCTG	0.383000													3	62					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11038797	11038797	+	RNA	SNP	T	T	C			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr21:11038797T>C	ENST00000470054.1	-	0	1406									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGCCAGTTTTTTGGAGTGACT	0.418000													12	104					0	0	1	0	0
T	6862	broad.mit.edu	37	6	166580164	166580164	+	Silent	SNP	C	C	T			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr6:166580164C>T	ENST00000296946.2	-	3	855	c.387G>A	c.(385-387)tcG>tcA	p.S129S	T_ENST00000366871.3_Silent_p.S129S	NM_003181.3	NP_003172.1	O15178	BRAC_HUMAN	T, brachyury homolog (mouse)	129					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		CGAAGTTGGGCGAGTCGGGGT	0.657000									Chordoma, Familial Clustering of				10	51					0	0	1	0	0
RGAG1	57529	broad.mit.edu	37	X	109696380	109696380	+	Missense_Mutation	SNP	G	G	C			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chrX:109696380G>C	ENST00000465301.2	+	3	2781	c.2535G>C	c.(2533-2535)atG>atC	p.M845I	RGAG1_ENST00000540313.1_Missense_Mutation_p.M845I	NM_020769.2	NP_065820.1	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	845										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						CTGGAGCAATGTCCATGCCAC	0.527000													66	110					0	0	1	0	0
ATG9B	285973	broad.mit.edu	37	7	150714208	150714208	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr7:150714208A>G	ENST00000605938.1	-	9	2279	c.2204T>C	c.(2203-2205)gTa>gCa	p.V735A	ATG9B_ENST00000377974.2_Missense_Mutation_p.V735A|ATG9B_ENST00000494791.1_5'UTR|ATG9B_ENST00000444312.1_Missense_Mutation_p.V221A	NM_173681.5	NP_775952.4	Q674R7	ATG9B_HUMAN	autophagy related 9B	735					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(4)|prostate(1)	14	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ATCTTGTTGTACTCGGCCCCA	0.652000													5	11					0	0	1	0	0
MRPS30	10884	broad.mit.edu	37	5	44811183	44811183	+	Missense_Mutation	SNP	G	G	T			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr5:44811183G>T	ENST00000507110.1	+	2	712	c.674G>T	c.(673-675)cGa>cTa	p.R225L		NM_016640.3	NP_057724.2	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	225					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome			central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(2)|lung(11)|prostate(1)	20	Lung NSC(6;8.08e-07)					CGAAGAGGTCGAATTGATGAC	0.363000													3	56					1	1	1	1	0
PPIP5K1	9677	broad.mit.edu	37	15	43827034	43827034	+	Silent	SNP	G	G	A			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr15:43827034G>A	ENST00000420765.1	-	31	4322	c.4140C>T	c.(4138-4140)atC>atT	p.I1380I	PPIP5K1_ENST00000360301.4_Silent_p.I1355I|PPIP5K1_ENST00000396923.3_Silent_p.I1380I|PPIP5K1_ENST00000360135.4_Silent_p.I1353I|PPIP5K1_ENST00000381879.4_Silent_p.I1356I|PPIP5K1_ENST00000381885.1_Silent_p.I1376I|PPIP5K1_ENST00000334933.4_Silent_p.I1355I|PPIP5K1_ENST00000348806.6_Silent_p.I1353I	NM_001130858.2	NP_001124330.1	Q6PFW1	VIP1_HUMAN	diphosphoinositol pentakisphosphate kinase 1	1380					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			large_intestine(1)	1						GGTATGGCTGGATGACCTCCT	0.527000													18	46					0	0	1	0	0
ZNF280C	55609	broad.mit.edu	37	X	129362988	129362988	+	Silent	SNP	G	G	A			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chrX:129362988G>A	ENST00000370978.4	-	10	1263	c.1110C>T	c.(1108-1110)tgC>tgT	p.C370C		NM_017666.4	NP_060136.1	Q8ND82	Z280C_HUMAN	zinc finger protein 280C	370					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(4)|large_intestine(9)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	26						TCTCAATGTGGCACTGCAGTT	0.448000													22	83					0	0	1	0	0
PLK2	10769	broad.mit.edu	37	5	57750746	57750746	+	Missense_Mutation	SNP	T	T	C			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr5:57750746T>C	ENST00000274289.3	-	13	2158	c.1858A>G	c.(1858-1860)Acc>Gcc	p.T620A	PLK2_ENST00000502671.1_Intron	NM_001252226.1|NM_006622.3	NP_001239155.1|NP_006613.2	Q9NYY3	PLK2_HUMAN	polo-like kinase 2	620	POLO box 2.				positive regulation of I-kappaB kinase/NF-kappaB cascade		ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			endometrium(7)|large_intestine(7)|lung(5)|ovary(3)|prostate(2)|skin(2)	26		all_cancers(5;1.76e-12)|all_epithelial(5;2.09e-13)|all_lung(5;6.64e-05)|Lung NSC(5;0.000127)|Prostate(74;0.055)|Breast(144;0.0602)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;7.03e-37)		ACCTGAAAGGTGCCATCATTA	0.403000													47	85					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8862406	8862406	+	Silent	SNP	C	C	T			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr20:8862406C>T	ENST00000338037.6	+	32	3588	c.3561C>T	c.(3559-3561)tcC>tcT	p.S1187S	PLCB1_ENST00000378641.3_3'UTR	NM_015192.2	NP_056007.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	1187					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						TCTCCCTGTCCTCAGACCCTG	0.507000													14	97					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79059041	79059041	+	Missense_Mutation	SNP	T	T	C			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr15:79059041T>C	ENST00000388820.4	-	19	3422	c.3212A>G	c.(3211-3213)aAt>aGt	p.N1071S		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1071					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.N1071S(4)		NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						CTCGTGGAAATTGATGAAATT	0.617000													4	37					0	0	1	0	0
EDDM3B	64184	broad.mit.edu	37	14	21238708	21238708	+	Silent	SNP	T	T	G			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr14:21238708T>G	ENST00000326783.3	+	2	497	c.399T>G	c.(397-399)gtT>gtG	p.V133V		NM_022360.4	NP_071755.1	P56851	EP3B_HUMAN	epididymal protein 3B	133					spermatid development	extracellular region				central_nervous_system(1)|kidney(1)|lung(3)|ovary(1)|skin(1)	7						ACGGGTATGTTGATAGCATAG	0.413000													11	18					0	0	1	0	0
PCDHB14	56122	broad.mit.edu	37	5	140605230	140605230	+	Missense_Mutation	SNP	G	G	T			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr5:140605230G>T	ENST00000239449.4	+	1	2153	c.2153G>T	c.(2152-2154)aGg>aTg	p.R718M	PCDHB14_ENST00000515856.2_Missense_Mutation_p.R565M	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		718					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGGAGGAGCAGGGCGGCCTCG	0.667000													5	192					0.00198382	0.0021758	1	1	0
RGS19	10287	broad.mit.edu	37	20	62705241	62705241	+	Silent	SNP	G	G	A			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr20:62705241G>A	ENST00000395042.1	-	6	885	c.619C>T	c.(619-621)Ctg>Ttg	p.L207L	RGS19_ENST00000332298.5_Silent_p.L207L	NM_005873.2	NP_005864.1	P49795	RGS19_HUMAN	regulator of G-protein signaling 19	207	Interaction with GIPC.				autophagy|G-protein coupled receptor protein signaling pathway|negative regulation of signal transduction|small GTPase mediated signal transduction	Golgi apparatus|membrane fraction|plasma membrane	GTPase activator activity|protein binding|signal transducer activity			lung(1)|prostate(1)|skin(1)	3	all_cancers(38;3.45e-11)|all_epithelial(29;9.12e-13)|Lung NSC(23;2e-09)|all_lung(23;6.77e-09)					GGCCCCTGCAGCAGCAGGGCA	0.672000													4	67					0	0	1	0	0
ALDH18A1	5832	broad.mit.edu	37	10	97396902	97396902	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr10:97396902A>G	ENST00000371224.2	-	5	643	c.506T>C	c.(505-507)cTg>cCg	p.L169P	ALDH18A1_ENST00000483788.1_5'UTR|ALDH18A1_ENST00000371221.3_Missense_Mutation_p.L169P	NM_002860.3	NP_002851.2	P54886	P5CS_HUMAN	aldehyde dehydrogenase 18 family, member A1	169	Glutamate 5-kinase.				proline biosynthetic process	mitochondrial inner membrane	ATP binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(9)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Colorectal(252;0.0402)		Epithelial(162;9.1e-07)|all cancers(201;2.55e-05)	L-Glutamic Acid(DB00142)	CAAGGCCATCAGCCCACTCTG	0.537000													3	27					0	0	1	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													3	23					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39889762	39889762	+	Silent	SNP	C	C	T			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr1:39889762C>T	ENST00000564288.1	+	61	16989	c.16212C>T	c.(16210-16212)ggC>ggT	p.G5404G	MACF1_ENST00000317713.7_Silent_p.G3342G|MACF1_ENST00000545844.1_Silent_p.G3342G|MACF1_ENST00000361689.2_Silent_p.G3342G|MACF1_ENST00000539005.1_Silent_p.G3321G|MACF1_ENST00000567887.1_Silent_p.G5441G|MACF1_ENST00000289893.4_Silent_p.G3844G|MACF1_ENST00000372915.3_Silent_p.G5409G			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	5409					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAGAAGGAGGCAGAATAGCCC	0.468000													6	54					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197348739	197348739	+	RNA	SNP	G	G	C			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr3:197348739G>C	ENST00000418868.1	-	0	520					NR_003266.2																						TAATTTTCTAGCTGTGAAAGA	0.398000													6	76					0	0	1	0	0