Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GPC2	221914	broad.mit.edu	37	7	99774681	99774681	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:99774681G>A	ENST00000292377.2	-	1	309	c.142C>T	c.(142-144)Cta>Tta	p.L48L		NM_152742.1	NP_689955.1	Q8N158	GPC2_HUMAN	glypican 2	48						anchored to membrane|endoplasmic reticulum|extracellular space|plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(3)	18	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGAGGGATTAGGTTTAAGCTA	0.632000													15	17					0	0	1	0	0
WNT11	7481	broad.mit.edu	37	11	75902877	75902877	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:75902877C>T	ENST00000322563.3	-	4	745	c.621G>A	c.(619-621)atG>atA	p.M207I	RP11-619A14.2_ENST00000527314.1_RNA	NM_004626.2	NP_004617.2	O96014	WNT11_HUMAN	wingless-type MMTV integration site family, member 11	207					adrenal gland development|anterior/posterior pattern formation|artery morphogenesis|axis specification|bone mineralization|cellular response to retinoic acid|cloacal septation|embryonic skeletal system development|endoderm development|lung-associated mesenchyme development|mesonephric duct development|negative regulation of apoptosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell migration|negative regulation of transcription, DNA-dependent|neuroendocrine cell differentiation|neuron differentiation|osteoblast differentiation|outflow tract morphogenesis|palate development|positive regulation of cell migration|positive regulation of protein kinase C signaling cascade|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor-beta2 production|protein localization at cell surface|protein phosphorylation|tight junction assembly|ureteric bud morphogenesis|ventricular septum morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|protein kinase activator activity|Ras GTPase activator activity|transcription regulatory region DNA binding			breast(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	20						ACTTACACTTCATTTCCAGAG	0.662000													16	41					0	0	1	0	0
KRT73	319101	broad.mit.edu	37	12	53002199	53002199	+	Silent	SNP	T	T	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:53002199T>C	ENST00000305748.3	-	9	1438	c.1404A>G	c.(1402-1404)acA>acG	p.T468T	RP11-641A6.2_ENST00000551089.1_RNA	NM_175068.2	NP_778238.1	Q86Y46	K2C73_HUMAN	keratin 73	468	Tail.					keratin filament	structural molecule activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.189)		AGCCAGCCCCTGTGCCTGCCA	0.617000													20	19					0	0	1	0	0
ITM2B	9445	broad.mit.edu	37	13	48833008	48833008	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr13:48833008C>T	ENST00000378565.5	+	5	843	c.640C>T	c.(640-642)Cac>Tac	p.H214Y	ITM2B_ENST00000378549.5_Missense_Mutation_p.H108Y	NM_021999.4	NP_068839.1	Q9Y287	ITM2B_HUMAN	integral membrane protein 2B	214	BRICHOS.				nervous system development	Golgi membrane|integral to membrane|nucleus|plasma membrane	beta-amyloid binding			endometrium(1)|large_intestine(2)|lung(3)	6		all_cancers(8;2.2e-31)|all_epithelial(8;6.77e-15)|all_lung(13;9.67e-07)|all_hematologic(8;9.72e-06)|Lung NSC(96;8.3e-05)|Breast(56;0.000141)|Acute lymphoblastic leukemia(8;0.00045)|Prostate(109;0.000669)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;1.97e-06)		AAACATTGATCACCTGGGTTT	0.353000													22	13					0	0	1	0	0
C10orf53	282966	broad.mit.edu	37	10	50901852	50901852	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:50901852C>T	ENST00000374113.3	+	2	177	c.130C>T	c.(130-132)Cta>Tta	p.L44L	C10orf53_ENST00000374112.3_Silent_p.L44L|C10orf53_ENST00000535836.1_Silent_p.L44L|C10orf53_ENST00000374111.3_Silent_p.L44L|CHAT_ENST00000455728.2_3'UTR			Q8N6V4	CJ053_HUMAN	chromosome 10 open reading frame 53	44										endometrium(1)|lung(6)	7		all_neural(218;0.107)				TGAGGTCATCCTAGAGAAGAT	0.468000													28	24					0	0	1	0	0
ZNF343	79175	broad.mit.edu	37	20	2465042	2465042	+	Missense_Mutation	SNP	T	T	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:2465042T>A	ENST00000278772.4	-	6	1052	c.565A>T	c.(565-567)Acc>Tcc	p.T189S	RP4-734P14.4_ENST00000461548.1_Intron	NM_024325.4	NP_077301.4	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	189					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|skin(4)|upper_aerodigestive_tract(1)	25						GCCCTTGAGGTTTCTCTCTCC	0.517000													34	30					0	0	1	0	0
TUBAL3	79861	broad.mit.edu	37	10	5442921	5442921	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:5442921C>T	ENST00000380419.3	-	2	170	c.133G>A	c.(133-135)Gaa>Aaa	p.E45K	TUBAL3_ENST00000479328.1_Missense_Mutation_p.E5K	NM_024803.2	NP_079079.1	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	45					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(7)|prostate(2)|skin(3)	25						TTTGCATTTTCCAGCTGATCC	0.493000													54	77					0	0	1	0	0
HPS5	11234	broad.mit.edu	37	11	18309543	18309543	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:18309543G>A	ENST00000396253.3	-	16	2578	c.2116C>T	c.(2116-2118)Cct>Tct	p.P706S	HPS5_ENST00000352460.3_5'UTR|HPS5_ENST00000349215.3_Missense_Mutation_p.P820S|HPS5_ENST00000438420.2_Missense_Mutation_p.P706S	NM_007216.3	NP_009147.3	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5	820						cytosol				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						ATATACACAGGATTGGAACTT	0.353000									Hermansky-Pudlak syndrome				16	20					0	0	1	0	0
SLC29A2	3177	broad.mit.edu	37	11	66130889	66130889	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:66130889G>A	ENST00000531602.1	+	2	271	c.138G>A	c.(136-138)aaG>aaA	p.K46K	RP11-867G23.8_ENST00000580881.1_Intron|SLC29A2_ENST00000311161.7_3'UTR|SLC29A2_ENST00000357440.2_3'UTR|SLC29A2_ENST00000544554.1_3'UTR|SLC29A2_ENST00000546034.1_3'UTR																kidney(1)	1						GGCTGCCAAAGAGCCTGGAGG	0.657000													4	8					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125504852	125504852	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:125504852C>T	ENST00000431078.1	+	14	2485	c.2121C>T	c.(2119-2121)caC>caT	p.H707H		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	707	Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		ATGAAAGGCACCCTTACTGGG	0.542000													15	14					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104129342	104129342	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:104129342G>A	ENST00000388887.2	+	52	5738	c.5534G>A	c.(5533-5535)gGa>gAa	p.G1845E		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1845	FAS1 6.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						GTGAAATGTGGAGCTGGCAGG	0.527000													11	14					0	0	1	0	0
CASQ1	844	broad.mit.edu	37	1	160160774	160160774	+	Missense_Mutation	SNP	A	A	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:160160774A>C	ENST00000368079.3	+	1	490	c.215A>C	c.(214-216)gAc>gCc	p.D72A	CASQ1_ENST00000368078.3_Missense_Mutation_p.D78A	NM_001231.4	NP_001222.3	P31415	CASQ1_HUMAN	calsequestrin 1 (fast-twitch, skeletal muscle)	78						mitochondrial matrix|sarcoplasmic reticulum lumen|smooth endoplasmic reticulum	calcium ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(1)	21	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CCCGAGGATGACAAGGCCTCA	0.527000													18	66					0	0	1	0	0
PHLPP2	23035	broad.mit.edu	37	16	71710379	71710379	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:71710379G>A	ENST00000393524.2	-	8	2175	c.1442C>T	c.(1441-1443)tCc>tTc	p.S481F	PHLPP2_ENST00000356272.3_Missense_Mutation_p.S481F|PHLPP2_ENST00000568954.1_Missense_Mutation_p.S481F|PHLPP2_ENST00000360429.3_Missense_Mutation_p.S481F|PHLPP2_ENST00000567016.1_Missense_Mutation_p.S516F			Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein phosphatase 2	481						cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37						GGTCCGAAGGGAAAAGCCACT	0.498000													18	23					0	0	1	0	0
SEPT14	346288	broad.mit.edu	37	7	55872980	55872980	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:55872980C>T	ENST00000388975.3	-	9	1206	c.1090G>A	c.(1090-1092)Gaa>Aaa	p.E364K		NM_207366.2	NP_997249.2	Q6ZU15	SEP14_HUMAN	septin 14	364					cell cycle|cell division	septin complex	GTP binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|skin(2)	23	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			AATGTTGCTTCTTTCTCCTTG	0.343000													9	13					0	0	1	0	0
STARD8	9754	broad.mit.edu	37	X	67938434	67938434	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chrX:67938434G>A	ENST00000252336.6	+	5	1810	c.1438G>A	c.(1438-1440)Gat>Aat	p.D480N	STARD8_ENST00000374597.3_Missense_Mutation_p.D480N|STARD8_ENST00000374599.3_Missense_Mutation_p.D560N	NM_014725.4	NP_055540.2	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain containing 8	480					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			NS(2)|breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	50						TGAACGGCGCGATTCAGGTGT	0.607000													15	0					0	0	1	0	0
HSPA5	3309	broad.mit.edu	37	9	128000509	128000509	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:128000509G>A	ENST00000324460.6	-	7	1516	c.1313C>T	c.(1312-1314)cCa>cTa	p.P438L		NM_005347.4	NP_005338.1	P11021	GRP78_HUMAN	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	438					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(4)|prostate(2)|skin(1)	23					Antihemophilic Factor(DB00025)	TGTGTTCCTTGGAATCAGTTT	0.403000										Prostate(1;0.17)			31	46					0	0	1	0	0
CCDC157	550631	broad.mit.edu	37	22	30772567	30772567	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr22:30772567T>C	ENST00000405659.1	+	12	2801	c.2092T>C	c.(2092-2094)Tct>Cct	p.S698P	CCDC157_ENST00000338306.3_Missense_Mutation_p.S698P|RP1-130H16.16_ENST00000332468.4_RNA			Q569K6	CC157_HUMAN	coiled-coil domain containing 157	698										central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|upper_aerodigestive_tract(1)	15						CACATCCCCATCTCGGCAGCC	0.667000													4	254					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38412636	38412636	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:38412636C>T	ENST00000322350.5	+	11	1726	c.1380C>T	c.(1378-1380)atC>atT	p.I460I	EGFLAM_ENST00000354891.3_Silent_p.I460I|EGFLAM_ENST00000397202.2_5'UTR|EGFLAM_ENST00000336740.6_Silent_p.I226I	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	460	Laminin G-like 1.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					TTGCCATCATCGTAAGTGAGA	0.488000													17	36					0	0	1	0	0
ATF5	22809	broad.mit.edu	37	19	50435781	50435781	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:50435781C>T	ENST00000423777.2	+	3	658	c.281C>T	c.(280-282)aCc>aTc	p.T94I	CTC-326K19.6_ENST00000451973.1_Intron|ATF5_ENST00000595125.1_Missense_Mutation_p.T94I	NM_001193646.1	NP_001180575.1	Q9Y2D1	ATF5_HUMAN	activating transcription factor 5	94					regulation of transcription from RNA polymerase II promoter	cytoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			NS(1)|endometrium(2)|large_intestine(1)|skin(3)	7		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00221)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		CCTTCCCCAACCCCACCTGAC	0.612000													39	59					0	0	1	0	0
CATSPERB	79820	broad.mit.edu	37	14	92088095	92088095	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:92088095C>T	ENST00000256343.3	-	19	2273	c.2117G>A	c.(2116-2118)aGg>aAg	p.R706K		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	706					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				TCGTCCATTCCTTTGCCCAAA	0.373000													21	47					0	0	1	0	0
OR2T4	127074	broad.mit.edu	37	1	248525857	248525857	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:248525857G>A	ENST00000366475.1	+	1	975	c.975G>A	c.(973-975)agG>agA	p.R325R		NM_001004696.1	NP_001004696.1	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T, member 4	325					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(2)|lung(47)	56	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATAGTCTTAGGAATAAGGATG	0.433000													19	87					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50952118	50952118	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:50952118C>T	ENST00000374103.4	-	14	1868	c.1783G>A	c.(1783-1785)Ggg>Agg	p.G595R	OGDHL_ENST00000432695.1_Missense_Mutation_p.G386R|OGDHL_ENST00000419399.1_Missense_Mutation_p.G538R	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	595					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						TCAGGGATCCCCGTGGCTGGG	0.587000													33	23					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33173951	33173951	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:33173951C>T	ENST00000404816.2	+	2	857	c.504C>T	c.(502-504)gtC>gtT	p.V168V	LTBP1_ENST00000354476.3_Silent_p.V168V			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	168					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GGGTCAATGTCTGTGGAGGGC	0.567000													43	67					0	0	1	0	0
THEMIS	387357	broad.mit.edu	37	6	128150743	128150743	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:128150743C>T	ENST00000368250.1	-	4	848	c.350G>A	c.(349-351)aGa>aAa	p.R117K	THEMIS_ENST00000537166.1_Missense_Mutation_p.R161K|THEMIS_ENST00000368248.2_Missense_Mutation_p.R196K|THEMIS_ENST00000543064.1_Missense_Mutation_p.R196K			Q8N1K5	THMS1_HUMAN	thymocyte selection associated	196	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(3)	60						AGTTCTTGTTCTGTTCTTAGG	0.353000													21	23					0	0	1	0	0
HGD	3081	broad.mit.edu	37	3	120352123	120352123	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:120352123C>T	ENST00000283871.5	-	13	1518	c.1059G>A	c.(1057-1059)aaG>aaA	p.K353K		NM_000187.3	NP_000178.2	Q93099	HGD_HUMAN	homogentisate 1,2-dioxygenase	353					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	homogentisate 1,2-dioxygenase activity|metal ion binding			cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(2)	25				GBM - Glioblastoma multiforme(114;0.158)		ACCCACCTTGCTTTGCCTCAT	0.522000													37	63					0	0	1	0	0
TAS2R9	50835	broad.mit.edu	37	12	10962128	10962128	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:10962128G>A	ENST00000240691.2	-	1	639	c.547C>T	c.(547-549)Ctg>Ttg	p.L183L		NM_023917.2	NP_076406.1	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9	183					sensory perception of taste	integral to membrane	taste receptor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						CCCAGGTTCAGGGTTAACTGT	0.393000													3	3					0	0	1	0	0
ESF1	51575	broad.mit.edu	37	20	13695808	13695808	+	Missense_Mutation	SNP	C	C	G			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:13695808C>G	ENST00000202816.1	-	14	2376	c.2269G>C	c.(2269-2271)Gtt>Ctt	p.V757L		NM_001276380.1|NM_016649.3	NP_001263309.1|NP_057733.2	Q9H501	ESF1_HUMAN	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)	757	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|skin(1)|stomach(1)	31						GCATCGTTAACATTTACCTGC	0.338000													11	6					0	0	1	0	0
UPF3A	65110	broad.mit.edu	37	13	115064450	115064450	+	Missense_Mutation	SNP	G	G	A	rs139333511	byFrequency	TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr13:115064450G>A	ENST00000375299.3	+	8	1038	c.982G>A	c.(982-984)Ggc>Agc	p.G328S	UPF3A_ENST00000475218.2_3'UTR|UPF3A_ENST00000351487.5_Missense_Mutation_p.G295S	NM_023011.3	NP_075387.1	Q9H1J1	REN3A_HUMAN	UPF3 regulator of nonsense transcripts homolog A (yeast)	328					mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|nucleus|plasma membrane	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			autonomic_ganglia(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	16	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)	OV - Ovarian serous cystadenocarcinoma(48;0.195)|Epithelial(10;0.2)		GCCCATGGAAGGCTCGCTGGA	0.542000													16	10					0	0	1	0	0
NRAS	4893	broad.mit.edu	37	1	115256529	115256529	+	Missense_Mutation	SNP	T	T	C	rs11554290		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:115256529T>C	ENST00000369535.4	-	3	435	c.182A>G	c.(181-183)cAa>cGa	p.Q61R		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(817)|p.Q61L(175)|p.Q61P(23)|p.Q61K(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458000	Q61L(C3A_LIVER)|Q61L(HEPG2_LIVER)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MELJUSO_SKIN)|Q61L(MHHES1_BONE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(HT1197_URINARY_TRACT)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(KU1919_URINARY_TRACT)|Q61R(NCIH2347_LUNG)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(SKMEL2_SKIN)|Q61R(SW1271_LUNG)|Q61R(TT2609C02_THYROID)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			74	126					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36121276	36121276	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:36121276G>A	ENST00000303965.4	-	24	4448	c.3959C>T	c.(3958-3960)aCc>aTc	p.T1320I		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1320					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						ACTCACTTGGGTGTCTTTCCA	0.289000													3	4					0	0	1	0	0
XKR7	343702	broad.mit.edu	37	20	30556550	30556550	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:30556550G>A	ENST00000217299.3	+	1	746	c.572G>A	c.(571-573)gGc>gAc	p.G191D		NM_001011718.1	NP_001011718.1	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related family, member 7	191						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			CTGCAGCTCGGCCAGGTCTGG	0.697000													10	4					0	0	1	0	0
PELI2	57161	broad.mit.edu	37	14	56763774	56763774	+	Missense_Mutation	SNP	C	C	T	rs138009911		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:56763774C>T	ENST00000267460.4	+	6	1439	c.1153C>T	c.(1153-1155)Ccg>Tcg	p.P385S		NM_021255.2	NP_067078.1	Q9HAT8	PELI2_HUMAN	pellino E3 ubiquitin protein ligase family member 2	385					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	protein binding			kidney(6)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	22						GTCTCAGATCCCGTTGCCTCA	0.498000													42	48					0	0	1	0	0
GPR3	2827	broad.mit.edu	37	1	27721279	27721279	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:27721279C>T	ENST00000374024.3	+	2	1076	c.977C>T	c.(976-978)tCc>tTc	p.S326F		NM_005281.2	NP_005272.1	P46089	GPR3_HUMAN	G protein-coupled receptor 3	326					activation of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane				endometrium(3)|lung(3)|ovary(1)|skin(1)	8		Breast(348;1.53e-05)|Ovarian(437;0.0606)|all_lung(284;0.157)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;2.81e-26)|Colorectal(126;1.24e-08)|KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;4.45e-06)|Lung(427;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|LUSC - Lung squamous cell carcinoma(448;0.008)|READ - Rectum adenocarcinoma(331;0.0419)		CGATCCCGCTCCCCCAGTGAT	0.532000													86	98					0	0	1	0	0
EXTL3	2137	broad.mit.edu	37	8	28574875	28574875	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:28574875C>T	ENST00000220562.4	+	3	2201	c.1299C>T	c.(1297-1299)atC>atT	p.I433I	EXTL3_ENST00000523149.1_Silent_p.I49I|EXTL3_ENST00000519886.1_Intron	NM_001440.2	NP_001431.1	O43909	EXTL3_HUMAN	exostosin-like glycosyltransferase 3	433						integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding	p.I433M(1)		biliary_tract(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(8)|ovary(1)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(1)	36		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		TCGCCCTCATCATTACCCCCG	0.622000													26	2					0	0	1	0	0
GHR	2690	broad.mit.edu	37	5	42700018	42700018	+	Missense_Mutation	SNP	C	C	T	rs45477803	byFrequency	TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:42700018C>T	ENST00000230882.4	+	6	722	c.532C>T	c.(532-534)Cca>Tca	p.P178S	GHR_ENST00000537449.1_5'UTR|GHR_ENST00000357703.3_Missense_Mutation_p.P156S	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor	178	Fibronectin type-III.				2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	ATGGGAAGCACCACGCAATGC	0.413000													16	12					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8518129	8518129	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:8518129G>A	ENST00000381196.4	-	18	1805	c.1262C>T	c.(1261-1263)cCg>cTg	p.P421L	PTPRD_ENST00000537002.1_Missense_Mutation_p.P418L|PTPRD_ENST00000360074.4_Missense_Mutation_p.P408L|PTPRD_ENST00000397611.3_Missense_Mutation_p.P418L|PTPRD_ENST00000486161.1_Missense_Mutation_p.P421L|PTPRD_ENST00000540109.1_Missense_Mutation_p.P421L|PTPRD_ENST00000355233.5_Missense_Mutation_p.P421L|PTPRD_ENST00000397617.3_Missense_Mutation_p.P411L|PTPRD_ENST00000356435.5_Missense_Mutation_p.P421L|PTPRD_ENST00000397606.3_Missense_Mutation_p.P411L|PTPRD_ENST00000358503.5_Missense_Mutation_p.P408L	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	421	Fibronectin type-III 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GACATCCCTCGGGGCACTGGA	0.498000										TSP Lung(15;0.13)			26	30					0	0	1	0	0
C2orf42	54980	broad.mit.edu	37	2	70387814	70387814	+	Missense_Mutation	SNP	G	G	A	rs146789788		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:70387814G>A	ENST00000264434.2	-	9	1838	c.1459C>T	c.(1459-1461)Cgt>Tgt	p.R487C	C2orf42_ENST00000420306.1_Missense_Mutation_p.R487C	NM_017880.1	NP_060350.1	Q9NWW7	CB042_HUMAN	chromosome 2 open reading frame 42	487										endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(1)	12						TTTTCTATACGACCGTAGGTT	0.418000													33	59					0	0	1	0	0
ACVR1B	91	broad.mit.edu	37	12	52377937	52377937	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:52377937C>T	ENST00000257963.4	+	5	1043	c.966C>T	c.(964-966)atC>atT	p.I322I	ACVR1B_ENST00000563121.1_3'UTR|ACVR1B_ENST00000426655.2_Silent_p.I322I|ACVR1B_ENST00000542485.1_Silent_p.I270I|ACVR1B_ENST00000541224.1_Silent_p.I363I|ACVR1B_ENST00000415850.2_Silent_p.I322I	NM_004302.4|NM_020328.3	NP_004293.1|NP_064733.3	P36896	ACV1B_HUMAN	activin A receptor, type IB	322	Protein kinase.				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			breast(5)|endometrium(4)|kidney(5)|large_intestine(12)|lung(10)|ovary(1)|pancreas(6)|prostate(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)	ACATGGAGATCGTGGGCACCC	0.522000													16	32					0	0	1	0	0
JADE1	79960	broad.mit.edu	37	4	129752966	129752966	+	Splice_Site	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:129752966G>A	ENST00000226319.6	+	2	332		c.e2+1		PHF17_ENST00000511647.1_Splice_Site|PHF17_ENST00000452328.2_Splice_Site|PHF17_ENST00000512960.1_Splice_Site|PHF17_ENST00000413543.2_Splice_Site	NM_199320.2	NP_955352.1	Q6IE81	JADE1_HUMAN							apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						GACAATGGCAGTAAGTCCTGC	0.488000													4	201					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24511518	24511518	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:24511518C>T	ENST00000264463.4	-	6	1427	c.920G>A	c.(919-921)cGa>cAa	p.R307Q		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	307	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		ATCAATAATTCGGTATTCTAC	0.438000										HNSCC(23;0.051)			50	63					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77369751	77369751	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:77369751G>A	ENST00000282849.5	-	12	2179	c.1761C>T	c.(1759-1761)ccC>ccT	p.P587P		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	587					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						GGCCGTGGATGGGCCGGGGCC	0.577000													78	111					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214814357	214814357	+	Silent	SNP	T	T	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:214814357T>C	ENST00000366955.3	+	12	2844	c.2676T>C	c.(2674-2676)acT>acC	p.T892T		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	892					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		AGGAAGACACTTCTGCTCACC	0.398000													17	57					0	0	1	0	0
CFHR1	3078	broad.mit.edu	37	1	196796106	196796106	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:196796106G>A	ENST00000320493.5	+	3	489	c.401G>A	c.(400-402)tGg>tAg	p.W134*	CFHR2_ENST00000367421.3_Intron|CFHR1_ENST00000367424.3_Nonsense_Mutation_p.W134*|CFHR1_ENST00000498248.1_3'UTR	NM_002113.2	NP_002104.2	Q03591	FHR1_HUMAN	complement factor H-related 1	134	Sushi 2.				complement activation	extracellular space				NS(1)|kidney(1)|large_intestine(2)|lung(7)	11						GAACGGGGCTGGTCCACCCCT	0.388000													58	5					0	0	1	0	0
CPED1	79974	broad.mit.edu	37	7	120876813	120876813	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:120876813C>T	ENST00000310396.5	+	17	2568	c.2101C>T	c.(2101-2103)Cct>Tct	p.P701S	CPED1_ENST00000450913.2_Missense_Mutation_p.P701S|CPED1_ENST00000423795.1_Missense_Mutation_p.P481S	NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		TGGGTTACAGCCTATTTCTTC	0.358000													3	17					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124358538	124358538	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:124358538C>T	ENST00000368909.3	+	26	3311	c.3205C>T	c.(3205-3207)Ctg>Ttg	p.L1069L	DMBT1_ENST00000344338.3_Silent_p.L1059L|DMBT1_ENST00000368955.3_Silent_p.L1059L|DMBT1_ENST00000330163.4_Silent_p.L570L|DMBT1_ENST00000368956.2_Silent_p.L570L|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000338354.3_Silent_p.L1069L	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1069	SRCR 8.			L -> P (in Ref. 1; CAA04019 and 2; AAD49696).	epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CGAGTCTTACCTGTGGAGCTG	0.587000													53	73					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41203238	41203238	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:41203238C>T	ENST00000263413.3	-	2	359	c.95G>A	c.(94-96)tGg>tAg	p.W32*	C6_ENST00000337836.5_Nonsense_Mutation_p.W32*	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	32	TSP type-1 1.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				GCAGCTGGTCCACTGAGTCCA	0.507000													20	32					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228529149	228529149	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:228529149C>T	ENST00000570156.2	+	85	20813	c.20739C>T	c.(20737-20739)atC>atT	p.I6913I	OBSCN_ENST00000284548.11_Silent_p.I5956I|OBSCN_ENST00000422127.1_Silent_p.I5956I|OBSCN_ENST00000366707.4_Silent_p.I3590I|OBSCN_ENST00000366709.4_Silent_p.I3075I	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	5956					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TGAGCAGCATCGACCTGAACG	0.647000													54	14					0	0	1	0	0
SPINT1	6692	broad.mit.edu	37	15	41148498	41148498	+	Missense_Mutation	SNP	G	G	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:41148498G>T	ENST00000344051.4	+	10	1595	c.1361G>T	c.(1360-1362)cGg>cTg	p.R454L	SPINT1_ENST00000562057.1_Missense_Mutation_p.R438L|SPINT1_ENST00000431806.1_Missense_Mutation_p.R438L			O43278	SPIT1_HUMAN	serine peptidase inhibitor, Kunitz type 1	454						extracellular region|membrane fraction	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	16		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		GGCCTGAGGCGGGAAATCCCC	0.537000													58	77					1.37693e-34	1.41743e-34	1	1	0
OR2L13	284521	broad.mit.edu	37	1	248263372	248263372	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:248263372G>A	ENST00000366478.2	+	3	1032	c.695G>A	c.(694-696)gGg>gAg	p.G232E	OR2L13_ENST00000358120.2_Missense_Mutation_p.G232E	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding	p.G232E(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			TCAAAGGAGGGGAGAAAAAAG	0.438000													19	71					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168833913	168833913	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:168833913C>T	ENST00000464456.1	-	7	2383	c.1183G>A	c.(1183-1185)Gat>Aat	p.D395N	MECOM_ENST00000392736.3_Missense_Mutation_p.D395N|MECOM_ENST00000460814.1_Missense_Mutation_p.D395N|MECOM_ENST00000494292.1_Missense_Mutation_p.D583N|MECOM_ENST00000468789.1_Missense_Mutation_p.D395N|MECOM_ENST00000264674.3_Missense_Mutation_p.D460N|MECOM_ENST00000433243.2_Missense_Mutation_p.D396N|MECOM_ENST00000472280.1_Missense_Mutation_p.D396N	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						CTGACATCATCAAGGTCACTA	0.468000													55	29					0	0	1	0	0
EYA4	2070	broad.mit.edu	37	6	133827288	133827288	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:133827288G>A	ENST00000367895.5	+	14	1700	c.1236G>A	c.(1234-1236)atG>atA	p.M412I	EYA4_ENST00000431403.2_Missense_Mutation_p.M412I|EYA4_ENST00000531901.1_Missense_Mutation_p.M418I|RP3-323P13.2_ENST00000607033.1_RNA|EYA4_ENST00000430974.2_Missense_Mutation_p.M364I|RP3-323P13.2_ENST00000451017.1_RNA|EYA4_ENST00000355286.6_Missense_Mutation_p.M389I|EYA4_ENST00000452339.2_Missense_Mutation_p.M358I|EYA4_ENST00000355167.3_Missense_Mutation_p.M412I|EYA4_ENST00000525849.1_Missense_Mutation_p.M389I	NM_004100.4	NP_004091.3	O95677	EYA4_HUMAN	eyes absent homolog 4 (Drosophila)	412					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|skin(1)	48	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		TGGAAGAAATGATTTTTAATC	0.353000													14	15					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12336845	12336845	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:12336845C>T	ENST00000358136.3	+	19	3330	c.3200C>T	c.(3199-3201)tCa>tTa	p.S1067L	VPS13D_ENST00000356315.4_Missense_Mutation_p.S1067L	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	1067					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ACTAGTGTTTCACTTGACAAA	0.458000											OREG0013110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	43	55					0	0	1	0	0
TTBK2	146057	broad.mit.edu	37	15	43038186	43038186	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:43038186G>A	ENST00000267890.6	-	15	3650	c.3542C>T	c.(3541-3543)tCg>tTg	p.S1181L		NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	1181	Ser-rich.				cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		ATGTGGGGACGAACTCCTCTG	0.592000													17	18					0	0	1	0	0
MYB	4602	broad.mit.edu	37	6	135517065	135517065	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:135517065C>T	ENST00000341911.5	+	9	1327	c.1128C>T	c.(1126-1128)atC>atT	p.I376I	MYB_ENST00000527615.1_Silent_p.I376I|MYB-AS1_ENST00000455534.1_RNA|MYB_ENST00000367814.4_Silent_p.I376I|MYB_ENST00000534121.1_Silent_p.I376I|MYB_ENST00000528774.1_Silent_p.I373I|MYB_ENST00000534044.1_Silent_p.I376I|MYB_ENST00000316528.8_Silent_p.I376I|MYB_ENST00000525369.1_Intron|MYB_ENST00000442647.2_Silent_p.I373I|MYB_ENST00000531845.1_3'UTR|MYB_ENST00000533624.1_Silent_p.I341I	NM_001130173.1|NM_001161656.1|NM_001161658.1	NP_001123645.1|NP_001155128.1|NP_001155130.1	P10242	MYB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog	376	Leucine-zipper.|Negative regulatory domain (By similarity).				blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	28	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		GGTGCATGATCGTCCACCAGG	0.478000			T	NFIB	adenoid cystic carcinoma								10	14					0	0	1	0	0
RAC2	5880	broad.mit.edu	37	22	37627401	37627401	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr22:37627401G>A	ENST00000249071.6	-	5	439	c.318C>T	c.(316-318)ccC>ccT	p.P106P	RAC2_ENST00000405484.1_Silent_p.P99P|RAC2_ENST00000406508.1_Silent_p.P62P	NM_002872.3	NP_002863.1	P15153	RAC2_HUMAN	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	106					axon guidance|platelet activation|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|protein binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(2)|upper_aerodigestive_tract(1)	12						TGGGTGTGCTGGGGCAGTGGT	0.622000													28	34					0	0	1	0	0
CFI	3426	broad.mit.edu	37	4	110681447	110681447	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:110681447C>T	ENST00000394634.2	-	6	1069	c.862G>A	c.(862-864)Gaa>Aaa	p.E288K	CFI_ENST00000394635.3_Missense_Mutation_p.E288K|CFI_ENST00000512148.1_Missense_Mutation_p.E288K	NM_000204.3	NP_000195.2	P05156	CFAI_HUMAN	complement factor I	288	LDL-receptor class A 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|skin(2)|stomach(1)	27		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		ACTTCATCTTCCCCTGTAATG	0.418000													37	54					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8485307	8485307	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:8485307G>A	ENST00000381196.4	-	26	3616	c.3073C>T	c.(3073-3075)Cat>Tat	p.H1025Y	PTPRD_ENST00000537002.1_Missense_Mutation_p.H611Y|PTPRD_ENST00000360074.4_Missense_Mutation_p.H1012Y|PTPRD_ENST00000397611.3_Missense_Mutation_p.H611Y|PTPRD_ENST00000486161.1_Missense_Mutation_p.H614Y|PTPRD_ENST00000540109.1_Missense_Mutation_p.H1025Y|PTPRD_ENST00000355233.5_Missense_Mutation_p.H614Y|PTPRD_ENST00000397617.3_Missense_Mutation_p.H604Y|PTPRD_ENST00000356435.5_Missense_Mutation_p.H1025Y|PTPRD_ENST00000397606.3_Missense_Mutation_p.H604Y|PTPRD_ENST00000358503.5_Missense_Mutation_p.H1003Y	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1025	Fibronectin type-III 8.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GCTTTGACATGAAAATTTTTT	0.378000										TSP Lung(15;0.13)			11	12					0	0	1	0	0
FNDC3A	22862	broad.mit.edu	37	13	49772236	49772236	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr13:49772236C>T	ENST00000492622.2	+	22	2914	c.2609C>T	c.(2608-2610)cCc>cTc	p.P870L	FNDC3A_ENST00000541916.1_Missense_Mutation_p.P870L|FNDC3A_ENST00000398316.3_Missense_Mutation_p.P814L	NM_001079673.1	NP_001073141.1	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	870	Fibronectin type-III 7.					Golgi membrane|integral to membrane				endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|prostate(5)|skin(2)|urinary_tract(1)	41		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		ATAGAAAATCCCCATTATTCA	0.443000													21	69					0	0	1	0	0
FCRL6	343413	broad.mit.edu	37	1	159778951	159778951	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:159778951G>A	ENST00000321935.6	+	5	627	c.541G>A	c.(541-543)Gac>Aac	p.D181N	FCRL6_ENST00000392235.3_Intron|FCRL6_ENST00000368106.3_Missense_Mutation_p.D174N|FCRL6_ENST00000339348.5_Missense_Mutation_p.D174N			Q6DN72	FCRL6_HUMAN	Fc receptor-like 6	174	Ig-like C2-type 2.					integral to membrane				NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	24	all_hematologic(112;0.0597)					CAAGGAGGGAGACTCTGGGCT	0.627000													62	26					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155508759	155508759	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:155508759C>T	ENST00000302053.3	-	4	493	c.415G>A	c.(415-417)Gaa>Aaa	p.E139K	FGA_ENST00000403106.3_Missense_Mutation_p.E139K	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	139					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TTCAGGACTTCAATTCTGCTT	0.408000													16	21					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167095139	167095139	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:167095139G>A	ENST00000361200.2	+	6	937	c.771G>A	c.(769-771)aaG>aaA	p.K257K	DUSP27_ENST00000443333.1_Silent_p.K257K|DUSP27_ENST00000271385.5_Silent_p.K257K			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	257	Tyrosine-protein phosphatase.				protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						CCGTGCGTAAGAAGCGGGCCA	0.582000													27	88					0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11211008	11211008	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:11211008C>T	ENST00000558518.1	+	2	364	c.177C>T	c.(175-177)tcC>tcT	p.S59S	LDLR_ENST00000455727.2_Silent_p.S59S|LDLR_ENST00000535915.1_Silent_p.S59S|LDLR_ENST00000545707.1_Silent_p.S59S|LDLR_ENST00000557933.1_Silent_p.S59S|LDLR_ENST00000558013.1_Silent_p.S59S	NM_000527.4|NM_001195798.1	NP_000518.1|NP_001182727.1	P01130	LDLR_HUMAN	low density lipoprotein receptor	59	LDL-receptor class A 1.				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity	p.?(1)		breast(2)|endometrium(2)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	CTGATGAGTCCCAGGAGACGT	0.517000													17	40					0	0	1	0	0
N4BP2	55728	broad.mit.edu	37	4	40121902	40121902	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:40121902C>T	ENST00000261435.6	+	9	2587	c.2171C>T	c.(2170-2172)tCa>tTa	p.S724L		NM_018177.4	NP_060647.2	Q86UW6	N4BP2_HUMAN	NEDD4 binding protein 2	724						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			breast(4)|endometrium(3)|kidney(12)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	60						GAGAGAGTATCACCTAGTACT	0.373000													44	42					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183609333	183609333	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:183609333G>A	ENST00000511685.1	+	12	2173	c.2050G>A	c.(2050-2052)Gac>Aac	p.D684N	TENM3_ENST00000502950.1_3'UTR|TENM3_ENST00000406950.2_Missense_Mutation_p.D684N					teneurin transmembrane protein 3																		ATGTTCTGTGGACTGTGGCTC	0.547000													75	89					0	0	1	0	0
FCN2	2220	broad.mit.edu	37	9	137774391	137774391	+	Silent	SNP	G	G	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:137774391G>T	ENST00000291744.6	+	2	130	c.120G>T	c.(118-120)ctG>ctT	p.L40L	FCN2_ENST00000350339.2_Intron	NM_004108.2	NP_004099.2	Q15485	FCN2_HUMAN	ficolin (collagen/fibrinogen domain containing lectin) 2	40					complement activation, lectin pathway|opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|calcium-dependent protein binding|receptor binding|sugar binding			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	20		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.58e-08)|Epithelial(140;6.41e-08)|all cancers(34;3.96e-07)		TGGTGGGCCTGGAGGGCTCTG	0.587000													35	58					1.59932e-28	1.63833e-28	1	1	0
SCIN	85477	broad.mit.edu	37	7	12684210	12684210	+	Splice_Site	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:12684210G>A	ENST00000297029.5	+	13	1862	c.1759_splice	c.e13-1	p.E587_splice	SCIN_ENST00000519209.1_Splice_Site_p.E340_splice|SCIN_ENST00000445618.2_Splice_Site_p.E340_splice	NM_001112706.2	NP_001106177.1	Q9Y6U3	ADSV_HUMAN	scinderin	587	Ca(2+)-dependent actin binding.				actin filament capping|actin filament severing|actin nucleation|calcium ion-dependent exocytosis|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of megakaryocyte differentiation|positive regulation of secretion|regulation of chondrocyte differentiation	cell cortex|cytoskeleton	1-phosphatidylinositol binding|actin filament binding|calcium ion binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding	p.E587D(2)		endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)	17				UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		TTTCCACAGAGGAGTTCTGGA	0.453000													5	6					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71050488	71050488	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:71050488C>T	ENST00000283228.2	-	13	2328	c.1876G>A	c.(1876-1878)Gat>Aat	p.D626N	PTPRR_ENST00000440835.2_Missense_Mutation_p.D381N|PTPRR_ENST00000549308.1_Missense_Mutation_p.D381N|PTPRR_ENST00000342084.4_Missense_Mutation_p.D514N|PTPRR_ENST00000537619.2_5'UTR|PTPRR_ENST00000378778.1_Missense_Mutation_p.D420N	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	626	Tyrosine-protein phosphatase.				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		ACTCACCTATCCATACGAAGC	0.468000													18	22					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8518130	8518130	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:8518130G>A	ENST00000381196.4	-	18	1804	c.1261C>T	c.(1261-1263)Ccg>Tcg	p.P421S	PTPRD_ENST00000537002.1_Missense_Mutation_p.P418S|PTPRD_ENST00000360074.4_Missense_Mutation_p.P408S|PTPRD_ENST00000397611.3_Missense_Mutation_p.P418S|PTPRD_ENST00000486161.1_Missense_Mutation_p.P421S|PTPRD_ENST00000540109.1_Missense_Mutation_p.P421S|PTPRD_ENST00000355233.5_Missense_Mutation_p.P421S|PTPRD_ENST00000397617.3_Missense_Mutation_p.P411S|PTPRD_ENST00000356435.5_Missense_Mutation_p.P421S|PTPRD_ENST00000397606.3_Missense_Mutation_p.P411S|PTPRD_ENST00000358503.5_Missense_Mutation_p.P408S	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	421	Fibronectin type-III 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ACATCCCTCGGGGCACTGGAT	0.502000										TSP Lung(15;0.13)			24	29					0	0	1	0	0
MTL5	9633	broad.mit.edu	37	11	68518091	68518091	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:68518091G>A	ENST00000443940.2	-	2	124	c.38C>T	c.(37-39)cCc>cTc	p.P13L	MTL5_ENST00000255087.5_Missense_Mutation_p.P13L|MTL5_ENST00000544963.1_Missense_Mutation_p.P13L			Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific (tesmin)	13					cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)	15	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			CGCATCCTCGGGGCTGGGCAG	0.711000													11	44					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152647630	152647630	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:152647630G>A	ENST00000367255.5	-	79	15695	c.15094C>T	c.(15094-15096)Ctc>Ttc	p.L5032F	SYNE1_ENST00000448038.1_Missense_Mutation_p.L4961F|SYNE1_ENST00000423061.1_Missense_Mutation_p.L4961F|SYNE1_ENST00000265368.4_Missense_Mutation_p.L5032F|SYNE1_ENST00000341594.5_Missense_Mutation_p.L4779F	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5032					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGGCTTTTGAGATTTTCCTCT	0.502000										HNSCC(10;0.0054)			20	27					0	0	1	0	0
MTHFD1	4522	broad.mit.edu	37	14	64909048	64909048	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:64909048C>T	ENST00000555709.1	+	21	2451	c.2064C>T	c.(2062-2064)tcC>tcT	p.S688S	MTHFD1_ENST00000216605.7_Silent_p.S744S|MTHFD1_ENST00000545908.1_Silent_p.S744S|CTD-2555O16.2_ENST00000556640.1_RNA	NM_005956.3	NP_005947.3	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	688	Formyltetrahydrofolate synthetase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase|methylenetetrahydrofolate dehydrogenase (NADP+) activity|protein binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	30				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	GCCGGTATTCCGGCCTCTGCC	0.507000													44	43					0	0	1	0	0
GPLD1	2822	broad.mit.edu	37	6	24450118	24450118	+	Missense_Mutation	SNP	G	G	A	rs61733858	byFrequency	TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:24450118G>A	ENST00000230036.1	-	15	1455	c.1345C>T	c.(1345-1347)Cgg>Tgg	p.R449W		NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	449						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						GAGCCAAACCGACCTGAGGGC	0.627000													21	178					0	0	1	0	0
REM1	28954	broad.mit.edu	37	20	30064402	30064402	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:30064402C>T	ENST00000201979.2	+	2	447	c.154C>T	c.(154-156)Ctc>Ttc	p.L52F	DEFB124_ENST00000481595.1_Intron	NM_014012.4	NP_054731.2	O75628	REM1_HUMAN	RAS (RAD and GEM)-like GTP-binding 1	52					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			kidney(3)|large_intestine(3)|lung(14)|pancreas(2)|upper_aerodigestive_tract(1)	23	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			ATCAGCCTCCCTCAACCCTCC	0.637000													23	46					0	0	1	0	0
NRAS	4893	broad.mit.edu	37	1	115256530	115256530	+	Missense_Mutation	SNP	G	G	T	rs121913254		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:115256530G>T	ENST00000369535.4	-	3	434	c.181C>A	c.(181-183)Caa>Aaa	p.Q61K		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61K(595)|p.Q61E(9)|p.Q61L(3)|p.Q61R(2)|p.G60>?(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TACTCTTCTTGTCCAGCTGTA	0.458000	Q61K(CHP212_AUTONOMIC_GANGLIA)|Q61K(HCC15_LUNG)|Q61K(HS936T_SKIN)|Q61K(HS944T_SKIN)|Q61K(HT1080_SOFT_TISSUE)|Q61K(HUT78_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(M07E_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(NCIH1299_LUNG)|Q61K(NCIH2087_LUNG)|Q61K(OCILY19_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(SKNAS_AUTONOMIC_GANGLIA)|Q61K(SKNSH_AUTONOMIC_GANGLIA)|Q61K(TYKNU_OVARY)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			75	131					1.16668e-32	1.19805e-32	1	1	0
SREBF2	6721	broad.mit.edu	37	22	42262864	42262864	+	Missense_Mutation	SNP	G	G	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr22:42262864G>C	ENST00000361204.4	+	2	284	c.118G>C	c.(118-120)Gga>Cga	p.G40R		NM_004599.2	NP_004590.2	Q12772	SRBP2_HUMAN	sterol regulatory element binding transcription factor 2	40	Transcriptional activation (acidic).				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			NS(2)|breast(6)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						TAATCAAGTGGGAGAGTTCCC	0.448000													58	90					0	0	1	0	0
DGKK	139189	broad.mit.edu	37	X	50163489	50163489	+	RNA	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chrX:50163489C>T	ENST00000376025.2	-	0	913							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					AGTGATTTTTCGTTGTGGTGT	0.383000													18	2					0	0	1	0	0
MMP7	4316	broad.mit.edu	37	11	102398352	102398352	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:102398352C>T	ENST00000260227.4	-	3	439	c.387G>A	c.(385-387)gtG>gtA	p.V129V		NM_002423.3	NP_002414.1	P09237	MMP7_HUMAN	matrix metallopeptidase 7 (matrilysin, uterine)	129					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12	all_cancers(8;2.04e-05)|all_epithelial(12;0.00053)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0105)|all cancers(10;0.0496)|Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0147)		AAGCCTTTGACACTAATCGAT	0.438000													94	182					0	0	1	0	0
KRT3	3850	broad.mit.edu	37	12	53189253	53189253	+	Missense_Mutation	SNP	C	C	G			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:53189253C>G	ENST00000417996.2	-	1	648	c.574G>C	c.(574-576)Ggg>Cgg	p.G192R	KRT3_ENST00000309505.3_Missense_Mutation_p.G192R	NM_057088.2	NP_476429.2	P12035	K2C3_HUMAN	keratin 3	192	Head.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|skin(1)	23						TTTACTTGCCCAATCTGGGGG	0.532000													47	51					0	0	1	0	0
TANGO2	128989	broad.mit.edu	37	22	20024569	20024569	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr22:20024569C>T	ENST00000456048.1	+	1	23	c.23C>T	c.(22-24)cCa>cTa	p.P8L	TANGO2_ENST00000432883.1_Intron|TANGO2_ENST00000434570.2_Missense_Mutation_p.P44L|TANGO2_ENST00000479679.1_Intron|TANGO2_ENST00000420290.2_Intron|TANGO2_ENST00000401833.1_Missense_Mutation_p.P44L|TANGO2_ENST00000401886.1_Intron|TANGO2_ENST00000447208.2_Intron|TANGO2_ENST00000327374.4_Intron|TANGO2_ENST00000398042.2_Intron					transport and golgi organization 2 homolog (Drosophila)																		GCGGGGACTCCAGTCAATGTA	0.602000													41	89					0	0	1	0	0
DNAJC11	55735	broad.mit.edu	37	1	6712908	6712908	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:6712908G>A	ENST00000377577.5	-	6	734	c.611C>T	c.(610-612)tCg>tTg	p.S204L	DNAJC11_ENST00000542246.1_Missense_Mutation_p.S166L|DNAJC11_ENST00000377573.5_Missense_Mutation_p.S114L|DNAJC11_ENST00000294401.7_Missense_Mutation_p.S204L|DNAJC11_ENST00000349363.6_Missense_Mutation_p.S166L	NM_018198.3	NP_060668.2	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	204					protein folding		heat shock protein binding|unfolded protein binding	p.S204L(1)		NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(11)|lung(8)|ovary(2)|skin(1)|urinary_tract(1)	32	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		TCCCTTTGCCGAAGTTACTCG	0.483000													34	58					0	0	1	0	0
CCND2	894	broad.mit.edu	37	12	4398035	4398035	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:4398035C>T	ENST00000261254.3	+	4	868	c.599C>T	c.(598-600)tCg>tTg	p.S200L		NM_001759.3	NP_001750.1	P30279	CCND2_HUMAN	cyclin D2	200					cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	17			all cancers(3;4.15e-10)|GBM - Glioblastoma multiforme(3;6.34e-05)|Colorectal(7;0.00245)|OV - Ovarian serous cystadenocarcinoma(31;0.00301)|COAD - Colon adenocarcinoma(12;0.0264)|STAD - Stomach adenocarcinoma(119;0.206)			TACCCACCGTCGATGATCGCA	0.552000			T	IGL@	"""NHL,CLL"""								65	126					0	0	1	0	0
POSTN	10631	broad.mit.edu	37	13	38151929	38151929	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr13:38151929G>A	ENST00000379747.4	-	16	2086	c.1969C>T	c.(1969-1971)Cgt>Tgt	p.R657C	POSTN_ENST00000379749.4_Missense_Mutation_p.R657C|POSTN_ENST00000379742.4_Missense_Mutation_p.R657C|POSTN_ENST00000541481.1_Missense_Mutation_p.R657C|POSTN_ENST00000379743.4_Missense_Mutation_p.R657C|POSTN_ENST00000541179.1_Missense_Mutation_p.R657C	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	657					cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		GTGCTACCACGAACAAACTGA	0.318000													11	19					0	0	1	0	0
HSPA5	3309	broad.mit.edu	37	9	128000510	128000510	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:128000510G>A	ENST00000324460.6	-	7	1515	c.1312C>T	c.(1312-1314)Cca>Tca	p.P438S		NM_005347.4	NP_005338.1	P11021	GRP78_HUMAN	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	438					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(4)|prostate(2)|skin(1)	23					Antihemophilic Factor(DB00025)	GTGTTCCTTGGAATCAGTTTG	0.403000										Prostate(1;0.17)			29	45					0	0	1	0	0
TBCB	1155	broad.mit.edu	37	19	36612445	36612445	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:36612445C>T	ENST00000221855.3	+	4	947	c.372C>T	c.(370-372)ttC>ttT	p.F124F	TBCB_ENST00000589996.1_Silent_p.F124F|TBCB_ENST00000392178.4_3'UTR|TBCB_ENST00000585746.1_Silent_p.F73F|TBCB_ENST00000586868.1_Intron	NM_001281.2	NP_001272.2	Q99426	TBCB_HUMAN	tubulin folding cofactor B	124					'de novo' posttranslational protein folding|cell differentiation|nervous system development	cytoplasm|microtubule	protein binding			large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	5	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TCCGCTCTTTCCTGAAGCGCA	0.697000													4	6					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	129037112	129037112	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:129037112C>T	ENST00000274487.4	+	20	3113	c.2968C>T	c.(2968-2970)Cga>Tga	p.R990*	ADAMTS19_ENST00000509467.1_3'UTR|CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	990	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CCCTTGTTCACGAACTTGTGG	0.458000													36	178					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94088581	94088581	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:94088581C>T	ENST00000553484.1	+	31	5222	c.5068C>T	c.(5068-5070)Ccc>Tcc	p.P1690S	UNC79_ENST00000393151.2_Missense_Mutation_p.P1668S|UNC79_ENST00000256339.4_Missense_Mutation_p.P1491S|UNC79_ENST00000555664.1_Missense_Mutation_p.P1668S			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1668						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						TGCCTCTTCTCCCTCCGTCCC	0.542000													13	28					0	0	1	0	0
OTOP3	347741	broad.mit.edu	37	17	72943475	72943475	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:72943475G>A	ENST00000328801.4	+	6	1525	c.1525G>A	c.(1525-1527)Gcc>Acc	p.A509T		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	509						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					CCTGCAGCGGGCCTCACTGGC	0.617000													52	30					0	0	1	0	0
OR1F2P	26184	broad.mit.edu	37	16	3265907	3265907	+	RNA	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:3265907G>A	ENST00000576468.1	+	0	418																											GTCTCATGCAGATGTATTTTA	0.512000													28	43					0	0	1	0	0
CAMK2D	817	broad.mit.edu	37	4	114458517	114458517	+	Missense_Mutation	SNP	C	C	G			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:114458517C>G	ENST00000454265.2	-	7	1355	c.497G>C	c.(496-498)gGg>gCg	p.G166A	CAMK2D_ENST00000342666.5_Missense_Mutation_p.G166A|CAMK2D_ENST00000511664.1_Missense_Mutation_p.G166A|CAMK2D_ENST00000514328.1_Missense_Mutation_p.G166A|CAMK2D_ENST00000379773.2_Missense_Mutation_p.G166A|CAMK2D_ENST00000505990.1_Missense_Mutation_p.G166A|CAMK2D_ENST00000394522.3_Missense_Mutation_p.G166A|CAMK2D_ENST00000394526.2_Missense_Mutation_p.G166A|CAMK2D_ENST00000515496.1_Missense_Mutation_p.G166A|CAMK2D_ENST00000508738.1_Missense_Mutation_p.G166A|CAMK2D_ENST00000394524.3_Missense_Mutation_p.G166A|CAMK2D_ENST00000429180.1_Missense_Mutation_p.G166A|CAMK2D_ENST00000296402.5_Missense_Mutation_p.G166A|CAMK2D_ENST00000418639.2_Missense_Mutation_p.G166A			Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II delta	166	Protein kinase.				interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	13		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		CTGCTGGTCCCCTTGAACTTC	0.463000													12	14					0	0	1	0	0
DHCR7	1717	broad.mit.edu	37	11	71152464	71152464	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:71152464G>A	ENST00000355527.3	-	6	711	c.435C>T	c.(433-435)atC>atT	p.I145I	DHCR7_ENST00000407721.2_Silent_p.I145I	NM_001163817.1|NM_001360.2	NP_001157289.1|NP_001351.2	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	145			I -> L (in SLOS).		cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(1)|skin(1)	19					NADH(DB00157)	GCAGGCCATTGATCTGATACT	0.552000									Smith-Lemli-Opitz syndrome				12	12					0	0	1	0	0
EFCAB13	124989	broad.mit.edu	37	17	45490198	45490198	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:45490198G>A	ENST00000331493.2	+	22	2749	c.2338G>A	c.(2338-2340)Gat>Aat	p.D780N	CTD-2026D20.2_ENST00000523101.1_RNA|EFCAB13_ENST00000517484.1_Missense_Mutation_p.D684N	NM_152347.4	NP_689560.3			EF-hand calcium binding domain 13																		TGGTATACCTGATTTGGAGCA	0.358000													15	17					0	0	1	0	0
KCNJ1	3758	broad.mit.edu	37	11	128709563	128709563	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:128709563G>A	ENST00000392665.2	-	2	720	c.576C>T	c.(574-576)atC>atT	p.I192I	KCNJ1_ENST00000392664.2_Silent_p.I211I|KCNJ1_ENST00000440599.2_Silent_p.I192I|KCNJ1_ENST00000392666.1_Silent_p.I192I|KCNJ1_ENST00000324036.3_Silent_p.I192I	NM_153764.2	NP_722448.1	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 1	211					excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			breast(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)	23	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	TAGCCACTCGGATTAGGAGGC	0.478000													21	2					0	0	1	0	0
OR8B2	26595	broad.mit.edu	37	11	124253093	124253093	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:124253093G>A	ENST00000375013.2	-	1	165	c.147C>T	c.(145-147)ttC>ttT	p.F49F		NM_001005468.1	NP_001005468.1	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B, member 2	49					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(13)|ovary(1)	23		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AATTTAGACCGAAAAGAGTGA	0.423000													18	3					0	0	1	0	0
SASH3	54440	broad.mit.edu	37	X	128922047	128922047	+	Splice_Site	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chrX:128922047G>A	ENST00000356892.3	+	2	267		c.e2+1		SASH3_ENST00000476532.1_3'UTR	NM_018990.3	NP_061863.1	O75995	SASH3_HUMAN	SAM and SH3 domain containing 3											breast(2)|endometrium(2)|large_intestine(1)|lung(3)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	12						GGATGATAACGTGAGTTTCAG	0.577000													17	1					0	0	1	0	0
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48874117	48874117	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:48874117G>A	ENST00000394754.1	+	8	3140	c.3026G>A	c.(3025-3027)gGa>gAa	p.G1009E	GTF2A1L_ENST00000430487.2_Missense_Mutation_p.G271E|LHCGR_ENST00000420913.3_Intron|STON1-GTF2A1L_ENST00000405008.1_Missense_Mutation_p.G1009E|GTF2A1L_ENST00000403751.3_Missense_Mutation_p.G305E|STON1-GTF2A1L_ENST00000402114.2_Missense_Mutation_p.G1009E|STON1-GTF2A1L_ENST00000394751.3_Missense_Mutation_p.G962E|STON1-GTF2A1L_ENST00000309827.2_Missense_Mutation_p.G1009E	NM_172311.2	NP_758515.1	B7ZL16	B7ZL16_HUMAN		962					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(22)|liver(2)|lung(49)|ovary(3)|pancreas(1)|prostate(4)|skin(4)	91		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AGGATGTATGGATGTGATTCT	0.433000													10	15					0	0	1	0	0
CORO1C	23603	broad.mit.edu	37	12	109041221	109041221	+	Silent	SNP	A	A	G			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:109041221A>G	ENST00000261401.3	-	11	1555	c.1383T>C	c.(1381-1383)cgT>cgC	p.R461R	CORO1C_ENST00000541050.1_Silent_p.R461R|CORO1C_ENST00000421578.2_Silent_p.R356R|CORO1C_ENST00000549772.1_Silent_p.R467R|CORO1C_ENST00000420959.2_Silent_p.R514R|CORO1C_ENST00000549384.1_5'UTR	NM_001105237.2|NM_001276471.1|NM_014325.2	NP_001098707.1|NP_001263400.1|NP_055140.1	Q9ULV4	COR1C_HUMAN	coronin, actin binding protein, 1C	461					actin cytoskeleton organization|phagocytosis|signal transduction	actin cytoskeleton	actin filament binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(12)|skin(4)	24						ACTTGGAAATACGCTCATCTT	0.418000													56	78					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55321911	55321911	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:55321911C>T	ENST00000314644.2	+	1	129	c.129C>T	c.(127-129)atC>atT	p.I43I		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	0					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						TATACATGATCCCTGTTGGAG	0.378000										HNSCC(20;0.049)			45	14					0	0	1	0	0
CASC5	57082	broad.mit.edu	37	15	40917185	40917185	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:40917185C>T	ENST00000346991.5	+	11	5191	c.4801C>T	c.(4801-4803)Caa>Taa	p.Q1601*	CASC5_ENST00000399668.2_Nonsense_Mutation_p.Q1575*			Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5	1601					acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(13)|lung(16)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		TTTAGCCTTTCAAACTGTTCA	0.338000													24	23					0	0	1	0	0
KLRF1	51348	broad.mit.edu	37	12	9994467	9994467	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:9994467G>A	ENST00000279544.3	+	4	458	c.394G>A	c.(394-396)Gag>Aag	p.E132K	KLRF1_ENST00000324214.4_Missense_Mutation_p.E82K|KLRF1_ENST00000537723.1_Intron|KLRF1_ENST00000354855.3_Intron	NM_016523.1	NP_057607.1	Q9NZS2	KLRF1_HUMAN	killer cell lectin-like receptor subfamily F, member 1	132	C-type lectin.				cell surface receptor linked signaling pathway	integral to plasma membrane	MHC class I receptor activity|sugar binding			breast(1)|endometrium(2)|large_intestine(4)|lung(6)	13						GTTCTCTAATGAGATGAAAAG	0.328000													4	9					0	0	1	0	0
IRGC	56269	broad.mit.edu	37	19	44224002	44224002	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:44224002G>A	ENST00000244314.5	+	2	1491	c.1292G>A	c.(1291-1293)gGa>gAa	p.G431E		NM_019612.3	NP_062558.1	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	431						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(2)	25		Prostate(69;0.0435)				TCCGGGGAGGGAGGTGGGGAG	0.587000													13	34					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33290791	33290791	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:33290791G>A	ENST00000280979.4	+	13	3942	c.3772G>A	c.(3772-3774)Gac>Aac	p.D1258N	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1258					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AAGTAATGAGGACCCTGGTTA	0.438000													11	8					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176679229	176679229	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:176679229C>T	ENST00000367662.3	+	11	4732	c.3568C>T	c.(3568-3570)Caa>Taa	p.Q1190*		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1190					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						ATACTTGGATCAATGGGCTAC	0.453000													39	14					0	0	1	0	0
ACSM4	341392	broad.mit.edu	37	12	7475882	7475882	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:7475882G>A	ENST00000399422.4	+	8	1226	c.1178G>A	c.(1177-1179)gGg>gAg	p.G393E		NM_001080454.1	NP_001073923.1	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	393					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			endometrium(6)|kidney(1)|lung(14)	21						GGTTCAATGGGGAAAGGAATG	0.388000													4	5					0	0	1	0	0
CHRNA4	1137	broad.mit.edu	37	20	61981222	61981222	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:61981222T>C	ENST00000370263.4	-	5	1762	c.1541A>G	c.(1540-1542)aAc>aGc	p.N514S	CHRNA4_ENST00000463705.1_5'UTR	NM_000744.6|NM_001256573.1	NP_000735.1|NP_001243502.1	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 (neuronal)	514					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	CGAGTGGGTGTTGCGAGAGGC	0.682000													5	7					0	0	1	0	0
LIN9	286826	broad.mit.edu	37	1	226453303	226453303	+	Missense_Mutation	SNP	C	C	G			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:226453303C>G	ENST00000328205.5	-	10	1562	c.1017G>C	c.(1015-1017)tgG>tgC	p.W339C	LIN9_ENST00000481685.1_Missense_Mutation_p.W304C|LIN9_ENST00000366801.1_Missense_Mutation_p.W288C	NM_173083.3	NP_775106.2	Q5TKA1	LIN9_HUMAN	lin-9 homolog (C. elegans)	323					cell cycle|DNA replication	nucleoplasm				breast(3)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		TTTTACTTCTCCACGGCGACT	0.323000													25	74					0	0	1	0	0
DOLPP1	57171	broad.mit.edu	37	9	131846956	131846956	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:131846956C>T	ENST00000372546.4	+	2	118	c.86C>T	c.(85-87)tCt>tTt	p.S29F	DOLPP1_ENST00000406974.3_Missense_Mutation_p.S29F|DOLPP1_ENST00000540102.1_5'UTR	NM_020438.4	NP_065171.2	Q86YN1	DOPP1_HUMAN	dolichyldiphosphatase 1	29					dolichyl diphosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane	dolichyldiphosphatase activity			endometrium(3)|kidney(2)|lung(7)|skin(1)	13						GGTGATCTCTCTGGCCACCTC	0.547000													257	336					0	0	1	0	0
GHR	2690	broad.mit.edu	37	5	42718700	42718700	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:42718700G>A	ENST00000230882.4	+	10	1281	c.1091G>A	c.(1090-1092)aGa>aAa	p.R364K	GHR_ENST00000537449.1_Missense_Mutation_p.R177K|GHR_ENST00000513625.1_3'UTR|GHR_ENST00000357703.3_Missense_Mutation_p.R342K	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor	364					2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	GACACAGACAGACTTCTAAGC	0.443000													34	31					0	0	1	0	0
CC2D1A	54862	broad.mit.edu	37	19	14034565	14034565	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:14034565C>T	ENST00000318003.7	+	17	2122	c.1881C>T	c.(1879-1881)ttC>ttT	p.F627F	CC2D1A_ENST00000589606.1_Silent_p.F627F	NM_017721.4	NP_060191.3	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	627					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	27			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			AGCAAGCCTTCGTCCGGGGTC	0.622000													31	50					0	0	1	0	0
NXPH4	11247	broad.mit.edu	37	12	57619168	57619168	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:57619168C>T	ENST00000349394.5	+	2	740	c.565C>T	c.(565-567)Ctg>Ttg	p.L189L	NXPH4_ENST00000555154.1_3'UTR	NM_007224.3	NP_009155.1	O95158	NXPH4_HUMAN	neurexophilin 4	189	IV (linker domain).				neuropeptide signaling pathway	extracellular region				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(2)|stomach(1)|upper_aerodigestive_tract(1)	10						GCTTCCTGGGCTGGGGCCCCC	0.761000													27	42					0	0	1	0	0
DCD	117159	broad.mit.edu	37	12	55038515	55038515	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:55038515G>A	ENST00000293371.6	-	5	504	c.315C>T	c.(313-315)gtC>gtT	p.V105V	DCD_ENST00000456047.2_3'UTR	NM_053283.2	NP_444513.1	P81605	DCD_HUMAN	dermcidin	105					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular region	protein binding			large_intestine(2)|lung(2)|ovary(1)|skin(1)	6		Myeloproliferative disorder(1001;0.0255)				CTGAGTCAAGGACGTCTTTAA	0.433000													5	6					0	0	1	0	0
NUP107	57122	broad.mit.edu	37	12	69125034	69125034	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:69125034G>A	ENST00000229179.4	+	21	2211	c.1879G>A	c.(1879-1881)Gaa>Aaa	p.E627K	NUP107_ENST00000539906.1_Missense_Mutation_p.E598K|NUP107_ENST00000378905.2_Intron	NM_020401.2	NP_065134.1	P57740	NU107_HUMAN	nucleoporin 107kDa	627					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding		NUP107/LGR5(2)	breast(3)|endometrium(4)|kidney(4)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(2)	39	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			GTTGGCTAAAGAAGCAGGTAA	0.378000													10	16					0	0	1	0	0
TLDC1	57707	broad.mit.edu	37	16	84529511	84529511	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:84529511G>A	ENST00000343629.6	-	3	344	c.162C>T	c.(160-162)gtC>gtT	p.V54V	RP11-517C16.4_ENST00000568771.1_RNA|TLDC1_ENST00000535580.1_Silent_p.V27V|TLDC1_ENST00000561807.1_5'UTR	NM_020947.3	NP_065998.3			TBC/LysM-associated domain containing 1																		GAGCTTCCCCGACGTGGTTCT	0.517000													74	65					0	0	1	0	0
ADCY1	107	broad.mit.edu	37	7	45697426	45697426	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:45697426G>A	ENST00000297323.7	+	6	1271	c.1249G>A	c.(1249-1251)Gac>Aac	p.D417N	ADCY1_ENST00000432715.1_Missense_Mutation_p.D192N	NM_021116.2	NP_066939.1	Q08828	ADCY1_HUMAN	adenylate cyclase 1 (brain)	417					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(33)|ovary(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	71					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Adenosine(DB00640)	GTGGCAGTACGACGTGTGGTC	0.617000													13	26					0	0	1	0	0
DYTN	391475	broad.mit.edu	37	2	207527908	207527908	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:207527908C>T	ENST00000452335.2	-	11	1468	c.1352G>A	c.(1351-1353)cGa>cAa	p.R451Q		NM_001093730.1	NP_001087199.1	A2CJ06	DYTN_HUMAN	dystrotelin	451						plasma membrane	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(24)|ovary(1)|upper_aerodigestive_tract(1)	36				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		TTCTGGATTTCGCAGAGCATG	0.473000													6	22					0	0	1	0	0
HGD	3081	broad.mit.edu	37	3	120347258	120347258	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:120347258G>A	ENST00000283871.5	-	14	1766	c.1307C>T	c.(1306-1308)cCc>cTc	p.P436L		NM_000187.3	NP_000178.2	Q93099	HGD_HUMAN	homogentisate 1,2-dioxygenase	436					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	homogentisate 1,2-dioxygenase activity|metal ion binding			cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(2)	25				GBM - Glioblastoma multiforme(114;0.158)		CCTGGAGTTGGGAGTGAAGTG	0.468000													19	43					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113377503	113377503	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:113377503G>A	ENST00000316407.4	-	7	3436	c.3026C>T	c.(3025-3027)tCt>tTt	p.S1009F	KIAA2018_ENST00000478658.1_Missense_Mutation_p.S1009F|KIAA2018_ENST00000491165.1_Intron	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	1009					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						AGCAAGATCAGATAGCAATGT	0.363000													27	24					0	0	1	0	0
OR4C12	283093	broad.mit.edu	37	11	50004013	50004013	+	Missense_Mutation	SNP	C	C	T	rs142499788		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:50004013C>T	ENST00000335238.4	-	1	58	c.25G>A	c.(25-27)Gaa>Aaa	p.E9K		NM_001005270.2	NP_001005270.1	Q96R67	OR4CC_HUMAN	olfactory receptor, family 4, subfamily C, member 12	9					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E9K(1)		NS(1)|kidney(4)|large_intestine(3)|liver(1)|lung(19)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	36						AAAATGAATTCAGTCACATTC	0.343000													11	12					0	0	1	0	0
FRS3	10817	broad.mit.edu	37	6	41743232	41743232	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:41743232G>A	ENST00000373018.3	-	4	429	c.178C>T	c.(178-180)Ctc>Ttc	p.L60F	FRS3_ENST00000259748.2_Missense_Mutation_p.L60F	NM_006653.3	NP_006644.1	O43559	FRS3_HUMAN	fibroblast growth factor receptor substrate 3	60	IRS-type PTB.				fibroblast growth factor receptor signaling pathway	plasma membrane	fibroblast growth factor receptor binding|insulin receptor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CGCAAGCAGAGATAAGGCCAG	0.637000													33	12					0	0	1	0	0
OR4K5	79317	broad.mit.edu	37	14	20389662	20389662	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:20389662G>A	ENST00000315915.4	+	1	922	c.897G>A	c.(895-897)agG>agA	p.R299R		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	299					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTGCCGTAAGGAAAATTGTGA	0.383000													9	15					0	0	1	0	0
RREB1	6239	broad.mit.edu	37	6	7229400	7229400	+	Silent	SNP	C	C	T	rs139799223		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:7229400C>T	ENST00000379938.2	+	10	1605	c.1068C>T	c.(1066-1068)gaC>gaT	p.D356D	RREB1_ENST00000379933.3_Silent_p.D356D|RREB1_ENST00000334984.6_Silent_p.D356D|RREB1_ENST00000349384.6_Silent_p.D356D	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	356					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				TGCCTGGTGACGCCCTGGACC	0.662000													10	68					0	0	1	0	0
KIF1C	10749	broad.mit.edu	37	17	4907163	4907163	+	Missense_Mutation	SNP	T	T	G			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:4907163T>G	ENST00000320785.5	+	10	1173	c.816T>G	c.(814-816)aaT>aaG	p.N272K		NM_006612.5	NP_006603.2	O43896	KIF1C_HUMAN	kinesin family member 1C	272	Kinesin-motor.				microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(4)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|skin(1)|urinary_tract(3)	30						CCAACATCAATAAGTCCCTGA	0.532000													4	52					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13364838	13364838	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:13364838G>A	ENST00000254508.5	-	34	4821	c.4739C>T	c.(4738-4740)gCc>gTc	p.A1580V		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1580					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					GTCTCCCACGGCAACAATCAC	0.587000													47	71					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111957591	111957591	+	Missense_Mutation	SNP	G	G	A	rs3835606		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:111957591G>A	ENST00000369732.3	-	11	1587	c.1532C>T	c.(1531-1533)tCt>tTt	p.S511F		NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	511				S -> P (in Ref. 2; AAB04126).	chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		ATAACCCACAGAGGTCAGGGT	0.567000													16	10					0	0	1	0	0
PRB4	5545	broad.mit.edu	37	12	11462314	11462314	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:11462314G>A	ENST00000279575.1	-	2	123	c.90C>T	c.(88-90)ttC>ttT	p.F30F	PRB4_ENST00000535904.1_Silent_p.F30F|PRB4_ENST00000445719.2_Silent_p.F30F	NM_001261399.1|NM_002723.4	NP_001248328.1|NP_002714.2	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	30						extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|skin(4)|upper_aerodigestive_tract(3)	30						CTGATATTAGGAAGAGAGATT	0.383000										HNSCC(22;0.051)			50	69					0	0	1	0	0
CATSPERD	257062	broad.mit.edu	37	19	5757877	5757877	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:5757877C>T	ENST00000381624.3	+	14	1363	c.1302C>T	c.(1300-1302)tcC>tcT	p.S434S	CATSPERD_ENST00000381614.2_Silent_p.S92S|CATSPERD_ENST00000309164.7_3'UTR	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	434						integral to membrane											ACCCCCACTCCCTGGGGTTCC	0.612000													18	42					0	0	1	0	0
TBL2	26608	broad.mit.edu	37	7	72987698	72987698	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:72987698G>A	ENST00000305632.5	-	4	791	c.550C>T	c.(550-552)Cct>Tct	p.P184S	TBL2_ENST00000432538.1_Missense_Mutation_p.P148S|TBL2_ENST00000459913.1_5'UTR|TBL2_ENST00000452475.1_Missense_Mutation_p.P184S	NM_012453.2	NP_036585.1	Q9Y4P3	TBL2_HUMAN	transducin (beta)-like 2	184										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	19		Lung NSC(55;0.0659)|all_lung(88;0.152)				TGCTTTTTAGGGAAGTCCTCT	0.562000													24	36					0	0	1	0	0
ITK	3702	broad.mit.edu	37	5	156672894	156672894	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:156672894C>T	ENST00000422843.3	+	15	1670	c.1518C>T	c.(1516-1518)ttC>ttT	p.F506F	ITK_ENST00000519749.1_3'UTR	NM_005546.3	NP_005537.3	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	506	Protein kinase.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(25)|ovary(8)|prostate(2)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	70	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTCCCAGGTTCGTTCTGGATG	0.537000			T	SYK	peripheral T-cell lymphoma								48	5					0	0	1	0	0
POPDC3	64208	broad.mit.edu	37	6	105609453	105609453	+	Nonsense_Mutation	SNP	A	A	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:105609453A>T	ENST00000254765.3	-	2	610	c.332T>A	c.(331-333)tTg>tAg	p.L111*	BVES-AS1_ENST00000369122.3_RNA|POPDC3_ENST00000474760.1_Intron|BVES-AS1_ENST00000580854.1_RNA|BVES-AS1_ENST00000580511.1_RNA	NM_022361.4	NP_071756.2	Q9HBV1	POPD3_HUMAN	popeye domain containing 3	111						integral to membrane				NS(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|skin(3)|urinary_tract(1)	26		all_cancers(87;4.87e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0157)|Colorectal(196;0.202)|Lung NSC(302;0.238)				GGAGCTGTACAACACTTGGAA	0.423000													113	144					0	0	1	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40259718	40259718	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:40259718C>T	ENST00000263791.5	+	9	1234	c.1191C>T	c.(1189-1191)atC>atT	p.I397I	EIF2AK4_ENST00000559624.1_Silent_p.I397I|EIF2AK4_ENST00000382727.2_Silent_p.I397I	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	397	Protein kinase 1.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		CAGGCCCCATCCCTGTGCATC	0.517000													20	31					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57480947	57480947	+	Missense_Mutation	SNP	C	C	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:57480947C>A	ENST00000371236.2	-	12	1316	c.1053G>T	c.(1051-1053)caG>caT	p.Q351H	DAB1_ENST00000414851.2_Missense_Mutation_p.Q333H|DAB1_ENST00000420954.2_Missense_Mutation_p.Q349H|DAB1_ENST00000371234.4_Missense_Mutation_p.Q351H|DAB1_ENST00000439789.2_Missense_Mutation_p.Q265H|DAB1_ENST00000371231.1_Missense_Mutation_p.Q384H|DAB1_ENST00000485760.1_5'UTR			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	384					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						GCCAGGGCTGCTGAGTGGCAG	0.632000													50	48					2.43698e-19	2.49034e-19	1	1	0
STIM1	6786	broad.mit.edu	37	11	4112532	4112532	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:4112532C>T	ENST00000300737.4	+	12	2131	c.1562C>T	c.(1561-1563)tCg>tTg	p.S521L	STIM1_ENST00000533977.1_Missense_Mutation_p.S348L|STIM1_ENST00000527651.1_Silent_p.F533F	NM_003156.3	NP_003147.2	Q13586	STIM1_HUMAN	stromal interaction molecule 1	521					activation of store-operated calcium channel activity|calcium ion transport|detection of calcium ion|platelet activation	integral to endoplasmic reticulum membrane|integral to plasma membrane|microtubule	calcium ion binding|microtubule plus-end binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|liver(1)|lung(14)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30		Breast(177;0.00159)|Medulloblastoma(188;0.00258)|all_neural(188;0.0233)		BRCA - Breast invasive adenocarcinoma(625;0.114)|LUSC - Lung squamous cell carcinoma(625;0.141)		CATTCCGATTCGGAGTCCTCC	0.552000													69	73					0	0	1	0	0
AP2B1	163	broad.mit.edu	37	17	33954713	33954713	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:33954713C>T	ENST00000262325.7	+	9	1676	c.1123C>T	c.(1123-1125)Cgg>Tgg	p.R375W	AP2B1_ENST00000592545.1_Missense_Mutation_p.R337W|AP2B1_ENST00000538556.1_Missense_Mutation_p.R318W|AP2B1_ENST00000589344.1_Missense_Mutation_p.R375W|AP2B1_ENST00000312678.8_Missense_Mutation_p.R375W|AP2B1_ENST00000537622.2_Missense_Mutation_p.R375W|AP2B1_ENST00000545922.2_3'UTR	NM_001282.2	NP_001273.1	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1 subunit	375					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			NS(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(6)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		AAAAGCTGTGCGGGCCATTGG	0.438000													3	65					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71507856	71507856	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:71507856C>T	ENST00000396073.3	+	9	994	c.713C>T	c.(712-714)cCa>cTa	p.P238L	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	238					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			GCAGAAAGTCCAGGCACAGAA	0.448000													29	39					0	0	1	0	0
FIGNL1	63979	broad.mit.edu	37	7	50513698	50513698	+	Missense_Mutation	SNP	A	A	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:50513698A>C	ENST00000419119.1	-	2	2841	c.1288T>G	c.(1288-1290)Tta>Gta	p.L430V	FIGNL1_ENST00000395556.2_Missense_Mutation_p.L430V|FIGNL1_ENST00000433017.1_Missense_Mutation_p.L430V|FIGNL1_ENST00000356889.4_Missense_Mutation_p.L430V			Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	430					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	29	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				GGTCCCCTTAAACCAGTAAAG	0.443000													20	25					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13871727	13871727	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:13871727C>T	ENST00000265104.4	-	23	3648	c.3544G>A	c.(3544-3546)Gaa>Aaa	p.E1182K	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1182	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GCATTAATTTCCTGCTCTAGG	0.373000									Kartagener syndrome				7	23					0	0	1	0	0
RAB30	27314	broad.mit.edu	37	11	82708292	82708292	+	Missense_Mutation	SNP	T	T	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:82708292T>A	ENST00000533486.1	-	3	351	c.67A>T	c.(67-69)Acg>Tcg	p.T23S	RAB30_ENST00000534141.1_Missense_Mutation_p.T23S|RAB30_ENST00000532548.1_Missense_Mutation_p.T23S|RAB30_ENST00000525117.1_Missense_Mutation_p.T23S|RAB30_ENST00000260056.2_Missense_Mutation_p.T23S|RAB30_ENST00000527633.1_Missense_Mutation_p.T23S|RP11-659G9.3_ENST00000527550.1_RNA	NM_014488.3	NP_055303.2	Q15771	RAB30_HUMAN	RAB30, member RAS oncogene family	23					protein transport|small GTPase mediated signal transduction	Golgi stack|plasma membrane	GTP binding|GTPase activity			endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13						ACGAGGCACGTCTTCCCCACA	0.483000													18	35					0	0	1	0	0
CBX7	23492	broad.mit.edu	37	22	39530536	39530536	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr22:39530536G>A	ENST00000216133.5	-	5	673	c.468C>T	c.(466-468)ttC>ttT	p.F156F	CBX7_ENST00000401405.3_Intron|CBX7_ENST00000475962.1_Intron	NM_175709.3	NP_783640.1	O95931	CBX7_HUMAN	chromobox homolog 7	156					chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex				endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7	Melanoma(58;0.04)					CGCGGGGCGGGAACTTCTTGC	0.701000													4	5					0	0	1	0	0
PLXNC1	10154	broad.mit.edu	37	12	94673364	94673364	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:94673364C>T	ENST00000258526.4	+	22	3963	c.3714C>T	c.(3712-3714)ttC>ttT	p.F1238F	RP11-1105G2.3_ENST00000551941.1_Intron|PLXNC1_ENST00000545312.1_5'UTR|PLXNC1_ENST00000547057.1_Silent_p.F285F	NM_005761.2	NP_005752.1	O60486	PLXC1_HUMAN	plexin C1	1238					axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(12)|lung(30)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						AAAAGATTTTCCAAGCATTCT	0.448000													33	37					0	0	1	0	0
ESYT1	23344	broad.mit.edu	37	12	56530642	56530642	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:56530642C>T	ENST00000394048.5	+	16	2011	c.1747C>T	c.(1747-1749)Cca>Tca	p.P583S	ESYT1_ENST00000267113.4_Missense_Mutation_p.P593S|ESYT1_ENST00000541590.1_Missense_Mutation_p.P593S	NM_001184796.1|NM_015292.2	NP_001171725.1|NP_056107.1	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	583						integral to membrane				breast(2)|endometrium(2)|large_intestine(4)|lung(10)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	28						CAGCTCTGGTCCAAACTCCAG	0.532000													39	47					0	0	1	0	0
OR1L1	26737	broad.mit.edu	37	9	125424063	125424063	+	Missense_Mutation	SNP	T	T	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:125424063T>A	ENST00000373686.1	+	1	219	c.219T>A	c.(217-219)gaT>gaA	p.D73E				Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L, member 1	73					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)	17						GACCTGAGGATCAGAAGCCGC	0.478000													15	19					0	0	1	0	0
TRBV5-4	28611	broad.mit.edu	37	7	142168545	142168545	+	RNA	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:142168545G>A	ENST00000454561.2	-	0	378																											TGGGGCCCCTGACCCAGGGCC	0.507000													19	29					0	0	1	0	0
SYTL2	54843	broad.mit.edu	37	11	85445046	85445046	+	Missense_Mutation	SNP	A	A	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:85445046A>C	ENST00000316356.4	-	7	1890	c.1326T>G	c.(1324-1326)aaT>aaG	p.N442K	SYTL2_ENST00000524452.1_Missense_Mutation_p.N441K|SYTL2_ENST00000389960.4_Missense_Mutation_p.N441K|SYTL2_ENST00000528231.1_Missense_Mutation_p.N441K|SYTL2_ENST00000527523.1_Missense_Mutation_p.N393K			Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2	441					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(22)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		CTTTGGGTTCATTGATGGTTG	0.383000													31	139					0	0	1	0	0
ORC1	4998	broad.mit.edu	37	1	52849185	52849185	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:52849185G>A	ENST00000371568.3	-	13	2138	c.1920C>T	c.(1918-1920)ccC>ccT	p.P640P	ORC1_ENST00000371566.1_Silent_p.P640P	NM_001190818.1|NM_001190819.1|NM_004153.3	NP_001177747.1|NP_001177748.1|NP_004144.2	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	640	Necessary and sufficient for ORC complex assembly.				cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding			breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						CCTTATGAGTGGGCCAGTCAA	0.527000													33	44					0	0	1	0	0
ANKRD46	157567	broad.mit.edu	37	8	101541941	101541941	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:101541941G>A	ENST00000520311.1	-	3	924	c.121C>T	c.(121-123)Cgt>Tgt	p.R41C	ANKRD46_ENST00000520552.1_Missense_Mutation_p.R41C|ANKRD46_ENST00000519597.1_Missense_Mutation_p.R41C|ANKRD46_ENST00000335659.3_Missense_Mutation_p.R41C|ANKRD46_ENST00000519316.1_Missense_Mutation_p.R41C	NM_001270378.1	NP_001257307.1	Q86W74	ANR46_HUMAN	ankyrin repeat domain 46	41						integral to membrane				kidney(1)|large_intestine(2)|lung(4)	7	all_cancers(14;5.07e-05)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000353)|all_lung(17;0.000998)		Epithelial(11;2.61e-11)|all cancers(13;5.03e-09)|OV - Ovarian serous cystadenocarcinoma(57;4.49e-06)|STAD - Stomach adenocarcinoma(118;0.0957)			CTGCTGTCACGAATATTTGGG	0.493000													21	126					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17052594	17052594	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:17052594G>A	ENST00000418129.2	+	2	1843	c.1378G>A	c.(1378-1380)Gaa>Aaa	p.E460K	PLCL2_ENST00000396755.2_Missense_Mutation_p.E460K|PLCL2_ENST00000432376.1_Missense_Mutation_p.E460K	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	586	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						TGTTACTGACGAAGATGAAGG	0.423000													14	10					0	0	1	0	0
FRMD5	84978	broad.mit.edu	37	15	44166495	44166495	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:44166495G>A	ENST00000417257.1	-	14	1477	c.1301C>T	c.(1300-1302)cCt>cTt	p.P434L	FRMD5_ENST00000484674.1_Missense_Mutation_p.P340L|FRMD5_ENST00000402883.1_Missense_Mutation_p.P434L	NM_032892.3	NP_116281.2	Q7Z6J6	FRMD5_HUMAN	FERM domain containing 5	434						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|cervix(1)|endometrium(2)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	14		all_cancers(109;2.29e-15)|all_epithelial(112;9.98e-13)|Lung NSC(122;4.89e-08)|all_lung(180;5.08e-07)|Melanoma(134;0.0275)		all cancers(107;8.63e-20)|GBM - Glioblastoma multiforme(94;3.63e-06)		CTCAGCCACAGGGGTGGGCAG	0.587000													30	32					0	0	1	0	0
CMTR2	55783	broad.mit.edu	37	16	71319194	71319194	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:71319194G>A	ENST00000338099.5	-	3	966	c.630C>T	c.(628-630)atC>atT	p.I210I	FTSJD1_ENST00000434935.2_Silent_p.I210I			Q8IYT2	FTSJ1_HUMAN		210						integral to membrane	methyltransferase activity|nucleic acid binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TCAGGGTCATGATATCACCAG	0.438000													45	57					0	0	1	0	0
NGF	4803	broad.mit.edu	37	1	115829256	115829256	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:115829256G>A	ENST00000369512.2	-	3	329	c.161C>T	c.(160-162)gCc>gTc	p.A54V	RP4-663N10.1_ENST00000425449.1_RNA	NM_002506.2	NP_002497.2	P01138	NGF_HUMAN	nerve growth factor (beta polypeptide)	54					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	13	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	CGCTGCCGGGGCGCTGCGGGC	0.622000													23	3					0	0	1	0	0
SYT17	51760	broad.mit.edu	37	16	19194943	19194943	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:19194943C>T	ENST00000562034.1	+	3	4040	c.242C>T	c.(241-243)tCg>tTg	p.S81L	SYT17_ENST00000562711.2_Missense_Mutation_p.S138L|SYT17_ENST00000568115.1_Missense_Mutation_p.S81L|SYT17_ENST00000355377.2_Missense_Mutation_p.S142L			Q9BSW7	SYT17_HUMAN	synaptotagmin XVII	142						membrane|synaptic vesicle	transporter activity			NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	17						ATCCAACCTTCGGTGCTCAGA	0.537000													13	29					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100645169	100645169	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:100645169C>T	ENST00000471714.1	-	2	366	c.257G>A	c.(256-258)gGg>gAg	p.G86E	ABI3BP_ENST00000532144.1_5'UTR|ABI3BP_ENST00000495063.1_Missense_Mutation_p.G86E|ABI3BP_ENST00000284322.5_Missense_Mutation_p.G86E			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	86						extracellular space				central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						TGTGAATTTCCCTTCAGCGGG	0.473000													16	11					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41203237	41203237	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:41203237C>T	ENST00000263413.3	-	2	360	c.96G>A	c.(94-96)tgG>tgA	p.W32*	C6_ENST00000337836.5_Nonsense_Mutation_p.W32*	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	32	TSP type-1 1.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				AGCAGCTGGTCCACTGAGTCC	0.502000													21	33					0	0	1	0	0
FAM184A	79632	broad.mit.edu	37	6	119345372	119345372	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:119345372G>A	ENST00000338891.7	-	2	1209	c.766C>T	c.(766-768)Cag>Tag	p.Q256*	FAM184A_ENST00000522284.1_Nonsense_Mutation_p.Q136*|FAM184A_ENST00000521531.1_Nonsense_Mutation_p.Q256*|RP11-351A11.1_ENST00000518570.1_RNA|FAM184A_ENST00000368475.4_Nonsense_Mutation_p.Q136*|FAM184A_ENST00000352896.5_Nonsense_Mutation_p.Q136*	NM_024581.4	NP_078857.5	Q8NB25	F184A_HUMAN	family with sequence similarity 184, member A	256										breast(2)|central_nervous_system(2)|endometrium(2)|kidney(5)|large_intestine(19)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(5)	52						TAAAAGGACTGAGCTTTATTC	0.403000													9	9					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20996486	20996486	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:20996486G>A	ENST00000261383.3	-	48	7577	c.7578C>T	c.(7576-7578)atC>atT	p.I2526I	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2526	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TCTTCTCCACGATGTCAGCCT	0.473000													26	24					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195517229	195517229	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:195517229C>T	ENST00000463781.3	-	2	1681	c.1222G>A	c.(1222-1224)Gag>Aag	p.E408K	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.E408K	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	413					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GATGTCTCCTCTGTGTTTCCA	0.463000													28	79					0	0	1	0	0
ANGPT4	51378	broad.mit.edu	37	20	853619	853619	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:853619C>T	ENST00000381922.3	-	9	1598	c.1496G>A	c.(1495-1497)cGg>cAg	p.R499Q	ANGPT4_ENST00000546022.1_3'UTR	NM_015985.2	NP_057069.1	Q9Y264	ANGP4_HUMAN	angiopoietin 4	499	Fibrinogen C-terminal.				anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)	27						GTCCAAAGGCCGTATCATCAT	0.572000													25	34					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168833255	168833255	+	Missense_Mutation	SNP	C	C	T	rs139044661		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:168833255C>T	ENST00000464456.1	-	7	3041	c.1841G>A	c.(1840-1842)gGa>gAa	p.G614E	MECOM_ENST00000392736.3_Missense_Mutation_p.G614E|MECOM_ENST00000460814.1_Missense_Mutation_p.G614E|MECOM_ENST00000494292.1_Missense_Mutation_p.G802E|MECOM_ENST00000468789.1_Missense_Mutation_p.G614E|MECOM_ENST00000264674.3_Missense_Mutation_p.G679E|MECOM_ENST00000433243.2_Missense_Mutation_p.G615E|MECOM_ENST00000472280.1_Missense_Mutation_p.G615E	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	23							sequence-specific DNA binding transcription factor activity	p.G614E(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						GACGTTGCTTCCTTTTTTTCC	0.488000													10	18					0	0	1	0	0
NETO1	81832	broad.mit.edu	37	18	70417352	70417352	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr18:70417352C>T	ENST00000327305.6	-	9	2143	c.1486G>A	c.(1486-1488)Gaa>Aaa	p.E496K	NETO1_ENST00000299430.2_Missense_Mutation_p.E495K|NETO1_ENST00000583169.1_Missense_Mutation_p.E496K	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	496					memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		GGCACCTCTTCGATTTCATCT	0.463000													4	7					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152725406	152725406	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:152725406G>A	ENST00000367255.5	-	46	7368	c.6767C>T	c.(6766-6768)tCc>tTc	p.S2256F	SYNE1_ENST00000448038.1_Missense_Mutation_p.S2263F|SYNE1_ENST00000423061.1_Missense_Mutation_p.S2263F|SYNE1_ENST00000265368.4_Missense_Mutation_p.S2256F|SYNE1_ENST00000341594.5_Missense_Mutation_p.S2293F|RP3-398G3.5_ENST00000458194.1_RNA	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2256					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATTAACTTTGGAATGCAGTTC	0.338000										HNSCC(10;0.0054)			21	21					0	0	1	0	0
C1orf172	126695	broad.mit.edu	37	1	27278715	27278715	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:27278715G>A	ENST00000320567.5	-	2	245	c.157C>T	c.(157-159)Cat>Tat	p.H53Y		NM_152365.2	NP_689578.2	Q8NAX2	CA172_HUMAN	chromosome 1 open reading frame 172	53	Pro-rich.									NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.37e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.22e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		TCTGGCCCATGGTGGCCAGGG	0.632000													8	17					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121038780	121038780	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:121038780C>T	ENST00000392793.1	+	19	5875	c.5604C>T	c.(5602-5604)atC>atT	p.I1868I	TECTA_ENST00000264037.2_Silent_p.I1868I			O75443	TECTA_HUMAN	tectorin alpha	1868	ZP.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GCACGCATATCATGTATAAAA	0.448000													36	4					0	0	1	0	0
DNM1P46	196968	broad.mit.edu	37	15	100332711	100332711	+	RNA	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:100332711G>A	ENST00000341853.1	-	0	1480					NR_003260.1																						CTCTGCAggggtgggggtggg	0.617000													93	50					0	0	1	0	0
PDIK1L	149420	broad.mit.edu	37	1	26441071	26441071	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:26441071C>T	ENST00000374271.4	+	3	559	c.272C>T	c.(271-273)tCc>tTc	p.S91F	PDIK1L_ENST00000374269.1_Missense_Mutation_p.S91F	NM_001243532.1|NM_001243533.1|NM_152835.4	NP_001230461.1|NP_001230462.1|NP_690048.1	Q8N165	PDK1L_HUMAN	PDLIM1 interacting kinase 1 like	91	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity			large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	7		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00239)|all_lung(284;0.00366)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.32e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000735)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.015)|READ - Rectum adenocarcinoma(331;0.0649)		TCTAATTCTTCCCTTTATTTA	0.423000													16	33					0	0	1	0	0
DAND5	199699	broad.mit.edu	37	19	13084349	13084349	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:13084349C>T	ENST00000317060.2	+	2	650	c.471C>T	c.(469-471)ccC>ccT	p.P157P	DAND5_ENST00000585548.1_3'UTR	NM_152654.2	NP_689867.1	Q8N907	DAND5_HUMAN	DAN domain family member 5, BMP antagonist	157	CTCK.					extracellular region				kidney(2)|lung(3)|ovary(1)	6			OV - Ovarian serous cystadenocarcinoma(19;1.87e-18)			GTTGGGCACCCGTGGTCCTGT	0.587000													64	91					0	0	1	0	0
CUZD1	50624	broad.mit.edu	37	10	124591900	124591900	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:124591900G>A	ENST00000368904.1	-	11	2667	c.1718C>T	c.(1717-1719)tCc>tTc	p.S573F	CUZD1_ENST00000545804.1_Missense_Mutation_p.S573F|CUZD1_ENST00000392790.1_Missense_Mutation_p.S573F			Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1	573					cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane		p.S573F(1)		NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|stomach(1)	39		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		AACCATGAAGGAAAACAGATG	0.408000													43	67					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227920702	227920702	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:227920702G>A	ENST00000396625.3	-	30	2882	c.2675C>T	c.(2674-2676)cCc>cTc	p.P892L	COL4A4_ENST00000329662.7_Missense_Mutation_p.P892L	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	892	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		ATCTCCAAAGGGACCTGGGAT	0.592000													13	37					0	0	1	0	0
MED13L	23389	broad.mit.edu	37	12	116409900	116409900	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:116409900G>A	ENST00000281928.3	-	26	6079	c.5873C>T	c.(5872-5874)tCc>tTc	p.S1958F		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1958					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		CACTACAAAGGACCCCTGGGG	0.468000													3	10					0	0	1	0	0
SMG1	23049	broad.mit.edu	37	16	18823443	18823443	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:18823443C>T	ENST00000446231.2	-	61	11040	c.10628G>A	c.(10627-10629)cGg>cAg	p.R3543Q	SMG1_ENST00000389467.3_Missense_Mutation_p.R3544Q|RP11-1035H13.2_ENST00000569096.1_RNA			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	3543					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						AGTGTTACTCCGGACTGCTAC	0.473000													19	23					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55233060	55233060	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:55233060A>G	ENST00000275493.2	+	15	1987	c.1810A>G	c.(1810-1812)Aac>Gac	p.N604D	EGFR_ENST00000344576.2_Missense_Mutation_p.N604D|EGFR_ENST00000455089.1_Missense_Mutation_p.N559D|EGFR_ENST00000342916.3_Missense_Mutation_p.N604D|EGFR_ENST00000454757.2_Missense_Mutation_p.N551D|EGFR_ENST00000442591.1_Missense_Mutation_p.N604D	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	604					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GGGAGAAAACAACACCCTGGT	0.572000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			32	50					0	0	1	0	0
CATSPERB	79820	broad.mit.edu	37	14	92091189	92091189	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:92091189G>A	ENST00000256343.3	-	18	2061	c.1905C>T	c.(1903-1905)gtC>gtT	p.V635V		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	635					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				TGAGTTTATAGACATTTCCAG	0.323000													8	11					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120580374	120580374	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:120580374G>A	ENST00000300648.6	-	44	5778	c.5766C>T	c.(5764-5766)atC>atT	p.I1922I		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	1922					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GAGTGGGTAGGATCTCACGCA	0.592000													43	40					0	0	1	0	0
ACHE	43	broad.mit.edu	37	7	100491048	100491048	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:100491048G>A	ENST00000302913.4	-	2	944	c.806C>T	c.(805-807)aCg>aTg	p.T269M	ACHE_ENST00000419336.2_Missense_Mutation_p.T269M|ACHE_ENST00000428317.1_Missense_Mutation_p.T269M|ACHE_ENST00000412389.1_Missense_Mutation_p.T269M|ACHE_ENST00000411582.1_Missense_Mutation_p.T269M|ACHE_ENST00000241069.5_Missense_Mutation_p.T269M	NM_015831.2	NP_056646.1	P22303	ACES_HUMAN	acetylcholinesterase	269					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			large_intestine(3)|lung(7)|skin(3)|urinary_tract(3)	16	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	CATGCCCACCGTGGCCCAGGG	0.716000													9	9					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67629389	67629389	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:67629389C>T	ENST00000335894.4	+	5	530	c.464C>T	c.(463-465)cCc>cTc	p.P155L	IQCH_ENST00000546225.1_5'UTR|IQCH_ENST00000358767.3_5'UTR	NM_001031715.2	NP_001026885.1	Q86VS3	IQCH_HUMAN	IQ motif containing H	155										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		TGCACAGATCCCTATTTCACT	0.378000													20	45					0	0	1	0	0
COPA	1314	broad.mit.edu	37	1	160262336	160262336	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:160262336G>A	ENST00000241704.7	-	28	3127	c.2898C>T	c.(2896-2898)ggC>ggT	p.G966G	COPA_ENST00000368069.3_Silent_p.G975G	NM_001098398.1|NM_004371.3	NP_001091868.1|NP_004362.2	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha	966					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(2)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	46	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AGGTTGTGCGGCCTCGGGCGT	0.502000													39	143					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85400630	85400630	+	Silent	SNP	G	G	A	rs142125273		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:85400630G>A	ENST00000258888.5	+	6	3434	c.3267G>A	c.(3265-3267)ccG>ccA	p.P1089P		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1089					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GTAGCACCCCGACTTCTCAGC	0.637000													38	22					0	0	1	0	0
CD177	57126	broad.mit.edu	37	19	43859933	43859933	+	RNA	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:43859933G>A	ENST00000378009.4	+	0	542				CD177_ENST00000607517.1_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				AGGCTCAGGGGAGGTAAGCCT	0.587000													25	39					0	0	1	0	0
OR5J2	282775	broad.mit.edu	37	11	55944509	55944509	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:55944509G>A	ENST00000312298.1	+	1	416	c.416G>A	c.(415-417)aGa>aAa	p.R139K		NM_001005492.1	NP_001005492.1	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J, member 2	139					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	44	Esophageal squamous(21;0.00693)					ATGTCTGATAGAAAGTGTGTG	0.448000													24	24					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	97658630	97658630	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:97658630C>T	ENST00000370192.3	-	20	2717	c.2617G>A	c.(2617-2619)Gac>Aac	p.D873N	DPYD-AS1_ENST00000422980.1_RNA	NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	873					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	CATACCTTGTCCATGAGTTCA	0.413000													10	15					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124352637	124352637	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:124352637G>A	ENST00000409039.3	+	42	7161	c.7136G>A	c.(7135-7137)gGa>gAa	p.G2379E		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2379					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GACACAGAAGGAGTTTGGGCC	0.493000													7	7					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16260038	16260038	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:16260038C>T	ENST00000375759.3	+	11	7507	c.7303C>T	c.(7303-7305)Ccc>Tcc	p.P2435S		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	2435	Interaction with MSX2 (By similarity).|Pro-rich.|RID.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TCCCCCACCTCCCCAGCCAGC	0.567000													16	13					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122002855	122002855	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:122002855G>A	ENST00000498619.1	+	7	2522	c.2084G>A	c.(2083-2085)gGc>gAc	p.G695D	CASR_ENST00000490131.1_Missense_Mutation_p.G685D|CASR_ENST00000296154.5_Missense_Mutation_p.G685D	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	685					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CCGGCCTTTGGCATCAGCTTC	0.607000													40	39					0	0	1	0	0
OR2L13	284521	broad.mit.edu	37	1	248263373	248263373	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:248263373G>A	ENST00000366478.2	+	3	1033	c.696G>A	c.(694-696)ggG>ggA	p.G232G	OR2L13_ENST00000358120.2_Silent_p.G232G	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			CAAAGGAGGGGAGAAAAAAGG	0.438000													18	71					0	0	1	0	0
MAMLD1	10046	broad.mit.edu	37	X	149639278	149639278	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chrX:149639278C>T	ENST00000370401.2	+	4	1743	c.1433C>T	c.(1432-1434)tCc>tTc	p.S478F	MAMLD1_ENST00000426613.2_Missense_Mutation_p.S453F|MAMLD1_ENST00000432680.2_Missense_Mutation_p.S453F|MAMLD1_ENST00000262858.5_Missense_Mutation_p.S478F			Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	478					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(4)|kidney(3)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)	37	Acute lymphoblastic leukemia(192;6.56e-05)					CCACAGTGTTCCCTGATCCGA	0.577000													45	3					0	0	1	0	0
C1orf106	55765	broad.mit.edu	37	1	200878023	200878023	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:200878023C>T	ENST00000367342.4	+	7	1195	c.995C>T	c.(994-996)cCc>cTc	p.P332L	C1orf106_ENST00000413687.2_Missense_Mutation_p.P247L	NM_018265.3	NP_060735.3	Q3KP66	CA106_HUMAN	chromosome 1 open reading frame 106	332	Pro-rich.									endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(2)	21						CTGGACCACCCCTATGAGAAG	0.637000													7	71					0	0	1	0	0
ZNF391	346157	broad.mit.edu	37	6	27368625	27368625	+	Missense_Mutation	SNP	A	A	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:27368625A>C	ENST00000244576.4	+	3	1021	c.476A>C	c.(475-477)cAc>cCc	p.H159P		NM_001076781.1	NP_001070249.1	Q9UJN7	ZN391_HUMAN	zinc finger protein 391	159					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|large_intestine(6)|lung(7)|pancreas(2)|skin(3)|upper_aerodigestive_tract(1)	21						CAAAGAACTCACACTGGAGAG	0.398000													31	258					0	0	1	0	0
SYNDIG1L	646658	broad.mit.edu	37	14	74876342	74876342	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:74876342C>T	ENST00000331628.3	-	2	353	c.106G>A	c.(106-108)Gaa>Aaa	p.E36K	SYNDIG1L_ENST00000554823.1_Missense_Mutation_p.E36K	NM_001105579.1	NP_001099049.1	A6NDD5	SYN1L_HUMAN	synapse differentiation inducing 1-like	36					response to biotic stimulus	Golgi apparatus|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|lung(8)|pancreas(1)|prostate(1)|skin(1)	14						TAGAGCTTTTCCTGGCAGGAC	0.667000													17	26					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150842491	150842491	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chrX:150842491C>T	ENST00000370357.4	+	15	2253	c.2008C>T	c.(2008-2010)Cct>Tct	p.P670S		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	670						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					TTCCAGCATTCCTCAGTTTCC	0.488000													44	6					0	0	1	0	0
C12orf4	57102	broad.mit.edu	37	12	4626315	4626315	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:4626315G>A	ENST00000261250.3	-	9	1161	c.1074C>T	c.(1072-1074)ttC>ttT	p.F358F	C12orf4_ENST00000545746.1_Silent_p.F358F	NM_020374.2	NP_065107.1	Q9NQ89	CL004_HUMAN	chromosome 12 open reading frame 4	358										NS(1)|endometrium(1)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	13			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)		CAATTCGGGGGAAATGGAAGT	0.383000													16	34					0	0	1	0	0
PADI2	11240	broad.mit.edu	37	1	17396660	17396660	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:17396660C>T	ENST00000375486.4	-	15	1750	c.1687G>A	c.(1687-1689)Gag>Aag	p.E563K	PADI2_ENST00000466151.1_5'UTR|PADI2_ENST00000444885.2_Missense_Mutation_p.E447K	NM_007365.2	NP_031391.2	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	563					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(12)|ovary(4)|pancreas(1)|skin(5)|urinary_tract(3)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	ATGTCCTGCTCTGTCAGTCCC	0.592000													86	80					0	0	1	0	0
WFDC10A	140832	broad.mit.edu	37	20	44258500	44258500	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:44258500G>A	ENST00000372643.3	+	1	336	c.48G>A	c.(46-48)ctG>ctA	p.L16L	WFDC9_ENST00000326000.1_Intron	NM_080753.2	NP_542791.1	Q9H1F0	WF10A_HUMAN	WAP four-disulfide core domain 10A	16						extracellular region	serine-type endopeptidase inhibitor activity			large_intestine(2)	2		Myeloproliferative disorder(115;0.0122)				GTGTGCTGCTGCTGCAGGCCC	0.592000											OREG0025983	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	16					0	0	1	0	0
MALAT1	378938	broad.mit.edu	37	11	65273245	65273245	+	RNA	SNP	T	T	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:65273245T>A	ENST00000534336.1	+	0	8013					NR_002819.2																						GTAGCTCTATTATAATACTTA	0.373000													23	26					0	0	1	0	0
POLQ	10721	broad.mit.edu	37	3	121208660	121208660	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:121208660G>A	ENST00000264233.5	-	16	3246	c.3118C>T	c.(3118-3120)Cga>Tga	p.R1040*		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	1040					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		TTCCAAGATCGAAAACTTCTG	0.408000								DNA polymerases (catalytic subunits)					7	16					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78433748	78433748	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:78433748G>A	ENST00000278550.7	-	24	4227	c.3765C>T	c.(3763-3765)ttC>ttT	p.F1255F		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		TTCCAGAGGGGAAGATCCTTC	0.517000													39	102					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121758886	121758886	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:121758886G>A	ENST00000261367.7	+	6	2023	c.595G>A	c.(595-597)Gag>Aag	p.E199K	SNCAIP_ENST00000379538.3_Intron|SNCAIP_ENST00000504884.2_Intron|SNCAIP_ENST00000542191.1_Intron|SNCAIP_ENST00000379536.2_Missense_Mutation_p.E152K|SNCAIP_ENST00000414317.2_Intron|SNCAIP_ENST00000379533.2_Missense_Mutation_p.E199K|SNCAIP_ENST00000261368.8_Missense_Mutation_p.E152K|SNCAIP_ENST00000503116.2_Missense_Mutation_p.E199K			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	152					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		CGACATGGATGAGATTCTGGA	0.507000													18	49					0	0	1	0	0
CNGA2	1260	broad.mit.edu	37	X	150906990	150906990	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chrX:150906990C>T	ENST00000329903.4	+	1	68	c.35C>T	c.(34-36)cCa>cTa	p.P12L		NM_005140.1	NP_005131.1	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	12					response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(4)|endometrium(4)|large_intestine(5)|lung(34)|prostate(2)	49	Acute lymphoblastic leukemia(192;6.56e-05)					AAGAGCTCCCCAGCCAATAAT	0.517000													57	10					0	0	1	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69049712	69049712	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:69049712G>A	ENST00000295381.3	+	10	1857	c.1438G>A	c.(1438-1440)Gaa>Aaa	p.E480K	ARHGAP25_ENST00000409202.3_Missense_Mutation_p.E481K|ARHGAP25_ENST00000409220.1_Missense_Mutation_p.E474K|ARHGAP25_ENST00000409030.3_Missense_Mutation_p.E473K|ARHGAP25_ENST00000467265.1_Missense_Mutation_p.E441K|ARHGAP25_ENST00000479844.1_Missense_Mutation_p.E174K	NM_001007231.2	NP_001007232.2	P42331	RHG25_HUMAN	Rho GTPase activating protein 25	480					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(20)|ovary(3)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	52						TAAGGCAGGGGAAGGGCACAG	0.512000													34	44					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856702	53856702	+	Missense_Mutation	SNP	G	G	A	rs150688663	by1000genomes	TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:53856702G>A	ENST00000458035.1	+	4	2891	c.2774G>A	c.(2773-2775)cGt>cAt	p.R925H	ZNF845_ENST00000595091.1_Missense_Mutation_p.R925H	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	925					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R925H(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						AAAACCTTCCGTCACAATTCA	0.363000													3	58					0	0	1	0	0
MARCH10	162333	broad.mit.edu	37	17	60802443	60802443	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:60802443C>T	ENST00000544856.2	-	8	2335	c.1957G>A	c.(1957-1959)Gag>Aag	p.E653K	RP11-156L14.1_ENST00000582564.1_RNA|MARCH10_ENST00000456609.2_Missense_Mutation_p.E654K|MARCH10_ENST00000583600.1_Missense_Mutation_p.E692K|RP11-156L14.1_ENST00000579201.1_RNA|RP11-156L14.1_ENST00000584597.1_RNA|RP11-156L14.1_ENST00000577270.1_RNA|MARCH10_ENST00000311269.5_Missense_Mutation_p.E654K			Q8NA82	MARHA_HUMAN	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	654							ligase activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|liver(1)|lung(15)	38						TCTCCCTCCTCCTCGGAGTCC	0.552000													10	33					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197030984	197030984	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:197030984C>T	ENST00000367412.1	-	3	424	c.381G>A	c.(379-381)ggG>ggA	p.G127G		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	127	Sushi 2.				blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						CTTCATCCTTCCCTCCAGTGG	0.393000													15	13					0	0	1	0	0
MLLT4-AS1	653483	broad.mit.edu	37	6	168227350	168227350	+	RNA	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:168227350G>A	ENST00000359760.5	-	0	39					NR_027906.1																						ACCGCTGGTCGGGAAGGAACC	0.701000													6	13					0	0	1	0	0
GCK	2645	broad.mit.edu	37	7	44192914	44192914	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:44192914G>A	ENST00000403799.3	-	2	663	c.194C>T	c.(193-195)aCc>aTc	p.T65I	GCK_ENST00000345378.2_Missense_Mutation_p.T66I|GCK_ENST00000395796.3_Missense_Mutation_p.T64I|GCK_ENST00000437084.1_Missense_Mutation_p.T65I	NM_000162.3	NP_000153.1	P35557	HXK4_HUMAN	glucokinase (hexokinase 4)	65					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	37						GCCTTCTGGGGTGGAGCGCAC	0.612000													36	57					0	0	1	0	0
MIB2	142678	broad.mit.edu	37	1	1560757	1560757	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:1560757C>T	ENST00000357210.4	+	7	1203	c.987C>T	c.(985-987)gtC>gtT	p.V329V	MIB2_ENST00000504599.1_Silent_p.V285V|MIB2_ENST00000518681.1_Silent_p.V321V|MIB2_ENST00000378708.1_Silent_p.V271V|MIB2_ENST00000378710.3_Silent_p.V329V|MIB2_ENST00000378712.1_Silent_p.V206V|MIB2_ENST00000520777.1_Silent_p.V386V|MIB2_ENST00000505820.2_Silent_p.V386V|MIB2_ENST00000360522.4_Silent_p.V329V|MIB2_ENST00000355826.5_Silent_p.V372V	NM_080875.2	NP_543151.2	Q96AX9	MIB2_HUMAN	mindbomb E3 ubiquitin protein ligase 2	329					Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|lung(7)|prostate(4)|upper_aerodigestive_tract(1)	18	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		ACACTGATGTCCTGCGGGAGA	0.697000													5	10					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57175892	57175892	+	Silent	SNP	G	G	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:57175892G>T	ENST00000537055.2	-	2	906	c.675C>A	c.(673-675)gcC>gcA	p.A225A		NM_001005850.2	NP_001005850.2			zinc finger protein 835											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						TGGCGCACTGGGCGCACGCGT	0.711000													18	7					2.35188e-11	2.38022e-11	1	1	0
LRRC37A6P	387646	broad.mit.edu	37	10	27536568	27536568	+	RNA	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:27536568C>T	ENST00000574842.1	+	0	255				LRRC37A6P_ENST00000284414.4_RNA																							GCACCCTGTTCCCTCCTGATC	0.552000													9	23					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56539255	56539255	+	Missense_Mutation	SNP	G	G	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:56539255G>T	ENST00000390649.3	+	7	1656	c.1656G>T	c.(1654-1656)atG>atT	p.M552I		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	552	NACHT.					mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		ACGACCTCATGGTTCAAGGAC	0.527000													12	11					6.72482e-11	6.78949e-11	1	1	0
TANC2	26115	broad.mit.edu	37	17	61176546	61176546	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:61176546C>T	ENST00000424789.2	+	3	154	c.150C>T	c.(148-150)tcC>tcT	p.S50S	TANC2_ENST00000389520.4_Silent_p.S50S	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	50							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						GTGGCATCTCCACAGAAAGCG	0.473000													2	3					0	0	1	0	0
SYK	6850	broad.mit.edu	37	9	93650843	93650843	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:93650843G>A	ENST00000375754.4	+	13	1917	c.1769G>A	c.(1768-1770)cGg>cAg	p.R590Q	SYK_ENST00000375746.1_Missense_Mutation_p.R590Q|SYK_ENST00000375747.1_Missense_Mutation_p.R567Q|SYK_ENST00000375751.4_Missense_Mutation_p.R567Q	NM_003177.5	NP_003168.2	P43405	KSYK_HUMAN	spleen tyrosine kinase	590	Protein kinase.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)|skin(2)|stomach(2)	26						AAAGGAGAGCGGATGGGGTGC	0.438000			T	"""ETV6, ITK"""	"""MDS, peripheral T-cell lymphoma"""								9	12					0	0	1	0	0
SPIRE2	84501	broad.mit.edu	37	16	89925586	89925586	+	Missense_Mutation	SNP	C	C	T	rs138861470		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:89925586C>T	ENST00000378247.3	+	9	1329	c.1286C>T	c.(1285-1287)cCg>cTg	p.P429L	SPIRE2_ENST00000393062.2_Missense_Mutation_p.P429L	NM_032451.1	NP_115827.1	Q8WWL2	SPIR2_HUMAN	spire-type actin nucleation factor 2	429					transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(10)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		GAAGAGTCTCCGTGTGGGGAG	0.652000													26	30					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124848237	124848237	+	Silent	SNP	G	G	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:124848237G>C	ENST00000356219.3	-	22	3071	c.2916C>G	c.(2914-2916)gcC>gcG	p.A972A	NCOR2_ENST00000404121.2_Silent_p.A525A|NCOR2_ENST00000429285.2_Silent_p.A954A|NCOR2_ENST00000405201.1_Silent_p.A972A|NCOR2_ENST00000397355.1_Silent_p.A955A|NCOR2_ENST00000404621.1_Silent_p.A954A	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	972					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TGGGGGGGATGGCAGCCGCTC	0.657000													67	103					0	0	1	0	0
FAM81B	153643	broad.mit.edu	37	5	94727109	94727109	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:94727109C>T	ENST00000283357.5	+	1	62	c.16C>T	c.(16-18)Ctt>Ttt	p.L6F		NM_152548.2	NP_689761.2	Q96LP2	FA81B_HUMAN	family with sequence similarity 81, member B	6										central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		ATTACAATTCCTTGGTACATT	0.373000													32	55					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18439842	18439842	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:18439842C>T	ENST00000433979.1	+	3	856	c.740C>T	c.(739-741)tCt>tTt	p.S247F	PIK3C2G_ENST00000266497.5_Missense_Mutation_p.S247F|PIK3C2G_ENST00000536967.1_3'UTR|RERGL_ENST00000541632.1_Intron|PIK3C2G_ENST00000535651.1_Missense_Mutation_p.S247F|PIK3C2G_ENST00000538779.1_Missense_Mutation_p.S247F	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	247					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				AGTCTGGCCTCTTTTTGCAAC	0.308000													3	4					0	0	1	0	0
ITGAV	3685	broad.mit.edu	37	2	187531505	187531505	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:187531505C>T	ENST00000261023.3	+	22	2515	c.2241C>T	c.(2239-2241)atC>atT	p.I747I	ITGAV_ENST00000374907.3_Silent_p.I711I|ITGAV_ENST00000433736.2_Silent_p.I701I|AC017101.10_ENST00000453665.1_RNA	NM_002210.3	NP_002201.1	P06756	ITAV_HUMAN	integrin, alpha V	747					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		ACTTACAAATCCAAAGGTATG	0.299000													32	21					0	0	1	0	0
IGHV4OR15-8	28317	broad.mit.edu	37	15	22473085	22473085	+	RNA	SNP	C	C	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:22473085C>A	ENST00000557788.2	-	0	185																											CCAGCCCCTTCCCTGGGGGCT	0.572000													18	48					2.94398e-08	2.96516e-08	1	1	0
MYH11	4629	broad.mit.edu	37	16	15872688	15872688	+	Missense_Mutation	SNP	G	G	T	rs150759461	byFrequency	TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:15872688G>T	ENST00000338282.6	-	7	845	c.739C>A	c.(739-741)Cgc>Agc	p.R247S	MYH11_ENST00000300036.5_Missense_Mutation_p.R247S|MYH11_ENST00000576790.1_Missense_Mutation_p.R247S|MYH11_ENST00000396324.3_Missense_Mutation_p.R254S|MYH11_ENST00000452625.2_Missense_Mutation_p.R254S	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	247	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						AAGTTGATGCGGATGAATTTG	0.552000			T	CBFB	AML								34	62					2.40579e-17	2.45251e-17	1	1	0
SYT4	6860	broad.mit.edu	37	18	40850323	40850323	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr18:40850323C>T	ENST00000255224.3	-	4	1629	c.1261G>A	c.(1261-1263)Gtg>Atg	p.V421M	SYT4_ENST00000590752.1_Missense_Mutation_p.V403M|SYT4_ENST00000586678.1_5'UTR	NM_020783.3	NP_065834.1	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	421						cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44						TCACAGAGCACGTGCCACTTG	0.463000													47	103					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84683440	84683440	+	Missense_Mutation	SNP	G	G	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:84683440G>C	ENST00000286744.5	+	24	4344	c.4120G>C	c.(4120-4122)Gga>Cga	p.G1374R	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.G1374R	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	1374	Ig-like C2-type 3.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			CAATGCTCTTGGAAAGGCAGT	0.453000													15	9					0	0	1	0	0
PDE4B	5142	broad.mit.edu	37	1	66833507	66833507	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:66833507A>G	ENST00000423207.2	+	12	1953	c.1468A>G	c.(1468-1470)Aca>Gca	p.T490A	PDE4B_ENST00000480109.2_Missense_Mutation_p.T272A|PDE4B_ENST00000371045.5_Missense_Mutation_p.T333A|PDE4B_ENST00000371049.3_Missense_Mutation_p.T505A|PDE4B_ENST00000329654.4_Missense_Mutation_p.T505A	NM_001037340.1	NP_001032417.1	Q07343	PDE4B_HUMAN	phosphodiesterase 4B, cAMP-specific	505					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	37					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	GCAGCGTCAGACACTCAGGAA	0.408000													30	24					0	0	1	0	0
GRK7	131890	broad.mit.edu	37	3	141499387	141499387	+	Missense_Mutation	SNP	A	A	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:141499387A>T	ENST00000264952.2	+	2	921	c.784A>T	c.(784-786)Acc>Tcc	p.T262S		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	262	Protein kinase.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						TGAGAGCAAGACCCATCTCTG	0.527000													28	57					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	120053707	120053707	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:120053707G>A	ENST00000313400.4	-	2	628	c.528C>T	c.(526-528)tcC>tcT	p.S176S	ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000361209.2_Silent_p.S176S|ASTN2_ENST00000373996.3_Silent_p.S176S			O75129	ASTN2_HUMAN	astrotactin 2	176						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						AGCTGCTCATGGAGACGTGGA	0.592000													32	57					0	0	1	0	0
SH3RF3	344558	broad.mit.edu	37	2	110049072	110049072	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:110049072C>T	ENST00000309415.6	+	6	1519	c.1519C>T	c.(1519-1521)Ctg>Ttg	p.L507L		NM_001099289.1	NP_001092759.1	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	507	SH3 3.						zinc ion binding			endometrium(2)|kidney(1)|large_intestine(6)|liver(2)|lung(5)|ovary(2)	18						GGGGGCGTCTCTGAGGACCGG	0.627000													8	9					0	0	1	0	0
ANAPC7	51434	broad.mit.edu	37	12	110819677	110819677	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:110819677T>C	ENST00000455511.3	-	8	1114	c.1114A>G	c.(1114-1116)Agt>Ggt	p.S372G	ANAPC7_ENST00000450008.2_Missense_Mutation_p.S372G	NM_016238.2	NP_057322.2	Q9UJX3	APC7_HUMAN	anaphase promoting complex subunit 7	372					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)	19						GCTTGAACACTATTACTGTTC	0.468000													15	14					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175334293	175334293	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:175334293C>T	ENST00000367674.1	-	12	3148	c.2440G>A	c.(2440-2442)Gag>Aag	p.E814K	TNR_ENST00000263525.2_Missense_Mutation_p.E814K	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	814	Fibronectin type-III 6.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					ATCTCTTCCTCCTCATCCCTG	0.527000													46	13					0	0	1	0	0
IDE	3416	broad.mit.edu	37	10	94223753	94223753	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:94223753G>A	ENST00000265986.6	-	21	2552	c.2496C>T	c.(2494-2496)atC>atT	p.I832I	IDE_ENST00000496903.1_5'UTR|IDE_ENST00000371581.5_Silent_p.I277I	NM_004969.3	NP_004960.2	P14735	IDE_HUMAN	insulin-degrading enzyme	832					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|urinary_tract(2)	33					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CGCTGAAGACGATATAGCCTG	0.458000													72	73					0	0	1	0	0
ETS2	2114	broad.mit.edu	37	21	40191500	40191500	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr21:40191500C>T	ENST00000360214.3	+	9	1345	c.885C>T	c.(883-885)tcC>tcT	p.S295S	ETS2_ENST00000360938.3_Silent_p.S295S	NM_001256295.1	NP_001243224.1	P15036	ETS2_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog 2	295					positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				TCCTCCAGTCCTGGAACAGCC	0.552000													30	36					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20999357	20999357	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:20999357G>A	ENST00000261383.3	-	45	6631	c.6632C>T	c.(6631-6633)tCc>tTc	p.S2211F	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2211	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GGCATTGATGGAAATGATATT	0.413000													62	70					0	0	1	0	0
OR52K2	119774	broad.mit.edu	37	11	4470843	4470843	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:4470843C>T	ENST00000325719.4	+	1	319	c.274C>T	c.(274-276)Cgg>Tgg	p.R92W		NM_001005172.2	NP_001005172.2	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K, member 2	92					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R92W(3)		NS(2)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|skin(6)	25		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)		GTTCAGGGATCGGGAGATAAA	0.527000													16	22					0	0	1	0	0
CATSPERG	57828	broad.mit.edu	37	19	38850181	38850181	+	Missense_Mutation	SNP	C	C	T	rs140177794		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:38850181C>T	ENST00000409235.3	+	14	1683	c.1568C>T	c.(1567-1569)tCg>tTg	p.S523L	CATSPERG_ENST00000410018.1_Missense_Mutation_p.S483L|CATSPERG_ENST00000215069.4_Intron	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	523					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane		p.S163L(1)		breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						ATGGCCAGATCGTTCCGTGGG	0.602000													33	25					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	75052643	75052643	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:75052643C>T	ENST00000261978.4	-	3	1130	c.744G>A	c.(742-744)agG>agA	p.R248R	LTBP2_ENST00000557425.1_Intron|LTBP2_ENST00000556690.1_Silent_p.R248R	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	248					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CCGCACTGCTCCTGCGCAGGT	0.667000													18	14					0	0	1	0	0
SKAP1	8631	broad.mit.edu	37	17	46247993	46247993	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:46247993C>T	ENST00000336915.6	-	10	924	c.855G>A	c.(853-855)gaG>gaA	p.E285E	SKAP1_ENST00000584924.1_Silent_p.E285E	NM_001075099.1|NM_003726.3	NP_001068567.1|NP_003717.3	Q86WV1	SKAP1_HUMAN	src kinase associated phosphoprotein 1	285					positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway	cytoplasm|nucleus|plasma membrane	antigen binding|protein kinase binding|SH2 domain binding			large_intestine(1)|lung(10)|prostate(2)|skin(4)|urinary_tract(1)	18						GAGTGCCACTCTCATCCTCTT	0.413000													40	60					0	0	1	0	0
REPS1	85021	broad.mit.edu	37	6	139266690	139266690	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:139266690T>C	ENST00000450536.2	-	3	996	c.422A>G	c.(421-423)aAg>aGg	p.K141R	REPS1_ENST00000258062.5_Missense_Mutation_p.K141R|REPS1_ENST00000367663.4_Missense_Mutation_p.K141R|REPS1_ENST00000409812.2_Missense_Mutation_p.K141R|REPS1_ENST00000415951.2_Missense_Mutation_p.K141R			Q96D71	REPS1_HUMAN	RALBP1 associated Eps domain containing 1	141						coated pit|plasma membrane	calcium ion binding|SH3 domain binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|upper_aerodigestive_tract(2)	19				GBM - Glioblastoma multiforme(68;0.000434)|OV - Ovarian serous cystadenocarcinoma(155;0.000548)		TACGGATCCCTTTTTCACTTG	0.478000													3	184					0	0	1	0	0
ENOX1	55068	broad.mit.edu	37	13	43843653	43843653	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr13:43843653C>T	ENST00000261488.6	-	13	2084	c.1507G>A	c.(1507-1509)Gaa>Aaa	p.E503K	ENOX1_ENST00000412891.1_Missense_Mutation_p.E503K	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	503					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		GACTGCTCTTCCTTTGCTTGT	0.388000													42	25					0	0	1	0	0
ADCY2	108	broad.mit.edu	37	5	7766907	7766907	+	Missense_Mutation	SNP	A	A	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:7766907A>C	ENST00000338316.4	+	17	2291	c.2202A>C	c.(2200-2202)ttA>ttC	p.L734F	ADCY2_ENST00000537121.1_Missense_Mutation_p.L554F	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	734					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						CGCAGAATTTATTTTTCCTCC	0.428000													7	233					0	0	1	0	0
SEC23B	10483	broad.mit.edu	37	20	18507119	18507119	+	Missense_Mutation	SNP	C	C	T	rs111758941		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:18507119C>T	ENST00000336714.3	+	8	1369	c.937C>T	c.(937-939)Cgt>Tgt	p.R313C	SEC23B_ENST00000377475.3_Missense_Mutation_p.R313C|SEC23B_ENST00000262544.2_Missense_Mutation_p.R313C|SEC23B_ENST00000377465.1_Missense_Mutation_p.R313C	NM_006363.4|NM_032985.4|NM_032986.3	NP_006354.2|NP_116780.1|NP_116781.1	Q15437	SC23B_HUMAN	Sec23 homolog B (S. cerevisiae)	313			R -> H.		ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	32						GATTCCTATTCGTTCTTGGCA	0.458000													18	35					0	0	1	0	0
IL6R	3570	broad.mit.edu	37	1	154403031	154403031	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:154403031C>T	ENST00000368485.3	+	3	844	c.407C>T	c.(406-408)cCt>cTt	p.P136L	IL6R_ENST00000344086.4_Missense_Mutation_p.P136L	NM_000565.3	NP_000556.1	P08887	IL6RA_HUMAN	interleukin 6 receptor	136					acute-phase response|ciliary neurotrophic factor-mediated signaling pathway|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|endocrine pancreas development|hepatic immune response|negative regulation of collagen biosynthetic process|negative regulation of interleukin-8 production|positive regulation of activation of Janus kinase activity|positive regulation of anti-apoptosis|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of leukocyte chemotaxis|positive regulation of MAPKKK cascade|positive regulation of osteoblast differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of apoptosis	apical plasma membrane|basolateral plasma membrane|extracellular space|interleukin-6 receptor complex	ciliary neurotrophic factor binding|enzyme binding|protein homodimerization activity		IL6R/ATP8B2(2)	breast(2)|large_intestine(1)|ovary(3)	6	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GAGTGGGGTCCTCGGAGCACC	0.572000													62	20					0	0	1	0	0
IL12RB1	3594	broad.mit.edu	37	19	18182969	18182969	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:18182969C>T	ENST00000600835.1	-	10	1277	c.974G>A	c.(973-975)gGt>gAt	p.G325D	IL12RB1_ENST00000593993.1_Missense_Mutation_p.G325D|IL12RB1_ENST00000430026.2_Missense_Mutation_p.G325D|IL12RB1_ENST00000322153.6_Missense_Mutation_p.G325D			P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1	325	Fibronectin type-III 3.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			endometrium(1)|kidney(1)|lung(3)|pancreas(1)|skin(2)	8						CAGGCCAGGACCAAATTGGTT	0.627000													16	20					0	0	1	0	0
CHL1	10752	broad.mit.edu	37	3	432786	432786	+	Missense_Mutation	SNP	A	A	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:432786A>C	ENST00000256509.2	+	22	3377	c.2735A>C	c.(2734-2736)aAc>aCc	p.N912T	CHL1_ENST00000397491.2_Missense_Mutation_p.N896T	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	896					axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TTAGCCTATAACTCTAAAGGA	0.373000													14	21					0	0	1	0	0
KIAA1432	57589	broad.mit.edu	37	9	5772727	5772727	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:5772727C>T	ENST00000414202.2	+	24	3971	c.3780C>T	c.(3778-3780)tcC>tcT	p.S1260S	KIAA1432_ENST00000418622.3_Silent_p.S1181S|KIAA1432_ENST00000449720.2_Silent_p.S1144S	NM_001206557.1|NM_020829.3	NP_001193486.1|NP_065880.2	Q4ADV7	RIC1_HUMAN	KIAA1432	1260						integral to membrane				breast(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(23)|prostate(1)|upper_aerodigestive_tract(1)	45		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		CTCATAAATCCCAGGTCCAGC	0.438000													5	15					0	0	1	0	0
MMP25	64386	broad.mit.edu	37	16	3107189	3107189	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:3107189G>A	ENST00000336577.4	+	5	1054	c.817G>A	c.(817-819)Gat>Aat	p.D273N	RP11-473M20.7_ENST00000573878.1_RNA|RP11-473M20.7_ENST00000570949.1_RNA|RP11-473M20.7_ENST00000572574.1_RNA|RP11-473M20.7_ENST00000576250.1_RNA|RP11-473M20.7_ENST00000573953.1_RNA	NM_022468.4	NP_071913.1	Q9NPA2	MMP25_HUMAN	matrix metallopeptidase 25	273					inflammatory response|proteolysis	anchored to membrane|cell surface|plasma membrane|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	14						GGATGACCGCGATGGCCTGCA	0.642000													77	233					0	0	1	0	0
SMG1	23049	broad.mit.edu	37	16	18823442	18823442	+	Silent	SNP	C	C	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:18823442C>A	ENST00000446231.2	-	61	11041	c.10629G>T	c.(10627-10629)cgG>cgT	p.R3543R	SMG1_ENST00000389467.3_Silent_p.R3544R|RP11-1035H13.2_ENST00000569096.1_RNA			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	3543					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						CAGTGTTACTCCGGACTGCTA	0.473000													19	21					1.64293e-13	1.67078e-13	1	1	0
SDC3	9672	broad.mit.edu	37	1	31349510	31349510	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:31349510G>A	ENST00000336798.7	-	1	2077	c.585C>T	c.(583-585)acC>acT	p.T195T	SDC3_ENST00000339394.6_Silent_p.T253T			O75056	SDC3_HUMAN	syndecan 3	253	Ser/Thr-rich (mucin-like).					integral to membrane	cytoskeletal protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Myeloproliferative disorder(586;0.0393)|Colorectal(325;0.0466)|all_neural(195;0.0966)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		STAD - Stomach adenocarcinoma(196;0.0197)|READ - Rectum adenocarcinoma(331;0.0649)		TTGGCCGGGAGGTAGCTGTGC	0.716000													5	12					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157504541	157504541	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:157504541C>T	ENST00000361835.3	-	8	1701	c.1544G>A	c.(1543-1545)tGg>tAg	p.W515*	FCRL5_ENST00000368190.3_Nonsense_Mutation_p.W515*|FCRL5_ENST00000368191.3_Nonsense_Mutation_p.W430*|FCRL5_ENST00000368189.3_Nonsense_Mutation_p.W515*|FCRL5_ENST00000356953.4_Nonsense_Mutation_p.W515*	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	515	Ig-like C2-type 5.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				TGAGCTGCTCCACAGGGGCAT	0.498000													3	29					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77387705	77387705	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:77387705C>T	ENST00000282849.5	-	10	1957	c.1539G>A	c.(1537-1539)caG>caA	p.Q513Q		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	513	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						CATCATAAATCTGTCCTGGTA	0.433000													38	36					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94913480	94913480	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:94913480C>T	ENST00000289495.5	+	15	3543	c.3327C>T	c.(3325-3327)tcC>tcT	p.S1109S	PPP1R9A_ENST00000340694.4_Intron|PPP1R9A_ENST00000456331.2_Silent_p.S1127S|PPP1R9A_ENST00000433360.1_Silent_p.S1149S|PPP1R9A_ENST00000433881.1_Intron|PPP1R9A_ENST00000424654.1_Silent_p.S1127S	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	903						cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			CTACAAGTTCCCTTCAGCCTT	0.468000										HNSCC(28;0.073)			7	8					0	0	1	0	0
IRX6	79190	broad.mit.edu	37	16	55363007	55363007	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:55363007C>T	ENST00000290552.7	+	5	2449	c.1117C>T	c.(1117-1119)Cca>Tca	p.P373S	RP11-26L20.3_ENST00000558730.2_RNA	NM_024335.2	NP_077311.2	P78412	IRX6_HUMAN	iroquois homeobox 6	373						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(2)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33						CCGGCCTAGGCCACGAAGTCC	0.637000													26	29					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50531975	50531975	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:50531975G>A	ENST00000374144.3	+	3	1673	c.1385G>A	c.(1384-1386)aGc>aAc	p.S462N	C10orf71_ENST00000323868.4_Missense_Mutation_p.S462N			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	462										endometrium(1)	1						TCAGCAGACAGCCAGCCAGCA	0.537000													20	49					0	0	1	0	0
CA1	759	broad.mit.edu	37	8	86250640	86250640	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:86250640C>T	ENST00000523953.1	-	4	1122	c.76G>A	c.(76-78)Gga>Aga	p.G26R	CA1_ENST00000431316.1_Missense_Mutation_p.G26R|CA1_ENST00000523022.1_Missense_Mutation_p.G26R|CA1_ENST00000518341.1_5'UTR|CA1_ENST00000522389.1_Intron|CA1_ENST00000256119.5_Missense_Mutation_p.G26R|CA1_ENST00000542576.1_Missense_Mutation_p.G26R|CA1_ENST00000432364.2_Missense_Mutation_p.G26R			P00915	CAH1_HUMAN	carbonic anhydrase I	26					one-carbon metabolic process	Golgi apparatus	carbonate dehydratase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	13		all_lung(136;4.89e-06)			Acetazolamide(DB00819)|Amlodipine(DB00381)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dichlorphenamide(DB01144)|Ethinamate(DB01031)|Ethoxzolamide(DB00311)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Levetiracetam(DB01202)|Methazolamide(DB00703)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)|Verapamil(DB00661)|Zonisamide(DB00909)	TGGTTATTTCCATTGGCAATG	0.418000													46	20					0	0	1	0	0
LINC00674	100499466	broad.mit.edu	37	17	66110653	66110653	+	RNA	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:66110653G>A	ENST00000435469.2	+	0	207																											CCTTGACTACGGAGGGGTTGC	0.393000													11	14					0	0	1	0	0
RAG1	5896	broad.mit.edu	37	11	36596355	36596355	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:36596355C>T	ENST00000299440.5	+	2	1613	c.1501C>T	c.(1501-1503)Cag>Tag	p.Q501*		NM_000448.2	NP_000439.1	P15918	RAG1_HUMAN	recombination activating gene 1	501					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				ACAGATTTTTCAGCCTTTGCA	0.512000									Familial Hemophagocytic Lymphohistiocytosis				26	51					0	0	1	0	0
SYK	6850	broad.mit.edu	37	9	93650844	93650844	+	Silent	SNP	G	G	C	rs149469439	by1000genomes	TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:93650844G>C	ENST00000375754.4	+	13	1918	c.1770G>C	c.(1768-1770)cgG>cgC	p.R590R	SYK_ENST00000375746.1_Silent_p.R590R|SYK_ENST00000375747.1_Silent_p.R567R|SYK_ENST00000375751.4_Silent_p.R567R	NM_003177.5	NP_003168.2	P43405	KSYK_HUMAN	spleen tyrosine kinase	590	Protein kinase.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)|skin(2)|stomach(2)	26						AAGGAGAGCGGATGGGGTGCC	0.438000			T	"""ETV6, ITK"""	"""MDS, peripheral T-cell lymphoma"""								9	12					0	0	1	0	0
SIGLEC11	114132	broad.mit.edu	37	19	50462039	50462039	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:50462039C>T	ENST00000447370.2	-	7	1314	c.1224G>A	c.(1222-1224)caG>caA	p.Q408Q	SIGLEC11_ENST00000426971.2_Silent_p.Q408Q	NM_052884.2	NP_443116.2	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11	408	Ig-like C2-type 3.				cell adhesion	integral to membrane	sugar binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(6)|pancreas(1)|prostate(1)|skin(1)	32		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		GGCCCACGGTCTGTCCCCACC	0.682000													33	32					0	0	1	0	0
FBXO38	81545	broad.mit.edu	37	5	147813044	147813044	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:147813044C>T	ENST00000340253.5	+	16	2879	c.2711C>T	c.(2710-2712)tCc>tTc	p.S904F	FBXO38_ENST00000296701.6_Missense_Mutation_p.S659F|FBXO38_ENST00000513826.1_Missense_Mutation_p.S659F|FBXO38_ENST00000394370.3_Missense_Mutation_p.S829F			Q6PIJ6	FBX38_HUMAN	F-box protein 38	904						cytoplasm|nucleus			ATG4C/FBXO38(2)	NS(1)|breast(2)|endometrium(7)|kidney(5)|large_intestine(9)|lung(15)|ovary(5)|prostate(2)|skin(2)|stomach(2)|urinary_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGATAAATCCACTAGTACA	0.413000													54	4					0	0	1	0	0
KIAA0319	9856	broad.mit.edu	37	6	24596453	24596453	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:24596453A>G	ENST00000535378.1	-	4	1064	c.422T>C	c.(421-423)cTa>cCa	p.L141P	KIAA0319_ENST00000543707.1_Missense_Mutation_p.L150P|KIAA0319_ENST00000378214.3_Missense_Mutation_p.L150P|KIAA0319_ENST00000430948.2_Missense_Mutation_p.L105P|KIAA0319_ENST00000537886.1_Missense_Mutation_p.L150P	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	150					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						CATCTCCTCTAGGCCCCAATC	0.577000													67	245					0	0	1	0	0
KIAA1683	80726	broad.mit.edu	37	19	18377214	18377214	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:18377214G>A	ENST00000392413.3	-	3	1351	c.1136C>T	c.(1135-1137)gCc>gTc	p.A379V	KIAA1683_ENST00000600328.2_Missense_Mutation_p.A379V|KIAA1683_ENST00000600359.2_Missense_Mutation_p.A333V	NM_001145304.1|NM_001145305.1|NM_025249.3	NP_001138776.1|NP_001138777.1|NP_079525.1	Q9H0B3	K1683_HUMAN	KIAA1683	379	Thr-rich.					mitochondrion				breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						ATACATCTGGGCTGGGGTCTT	0.562000													39	49					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48686246	48686246	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:48686246C>T	ENST00000544264.1	-	19	6978	c.6698G>A	c.(6697-6699)cGa>cAa	p.R2233Q	CELSR3_ENST00000164024.4_Missense_Mutation_p.R2228Q			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	2228					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGCAGTGACTCGAACATCTTG	0.602000													20	42					0	0	1	0	0
SP140L	93349	broad.mit.edu	37	2	231235650	231235650	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:231235650G>A	ENST00000243810.6	+	6	551	c.551G>A	c.(550-552)aGg>aAg	p.R184K	SP140L_ENST00000396563.4_Missense_Mutation_p.R184K|SP140L_ENST00000444636.1_Missense_Mutation_p.R184K|SP140L_ENST00000415673.2_Missense_Mutation_p.R184K|SP140L_ENST00000458341.1_Missense_Mutation_p.R97K			Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	184						nucleus	DNA binding|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|skin(1)	20						CCGGAAGCAAGGAAGGAAAGT	0.552000													8	17					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40727129	40727129	+	Missense_Mutation	SNP	A	A	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:40727129A>T	ENST00000373198.3	-	28	4079	c.3844T>A	c.(3844-3846)Ttc>Atc	p.F1282I	PTPRT_ENST00000373187.1_Missense_Mutation_p.F1260I|PTPRT_ENST00000373190.1_Missense_Mutation_p.F1259I|PTPRT_ENST00000373193.3_Missense_Mutation_p.F1263I|PTPRT_ENST00000373201.1_Missense_Mutation_p.F1250I|PTPRT_ENST00000356100.2_Missense_Mutation_p.F1269I|PTPRT_ENST00000373184.1_Missense_Mutation_p.F1270I	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1260	Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				AGCCTCCAGAAGTCTGCCACG	0.562000													46	41					0	0	1	0	0
DENND1A	57706	broad.mit.edu	37	9	126202651	126202651	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:126202651G>A	ENST00000373624.2	-	19	1677	c.1476C>T	c.(1474-1476)gtC>gtT	p.V492V	DENND1A_ENST00000373618.1_Silent_p.V460V|DENND1A_ENST00000542603.1_Silent_p.V234V|DENND1A_ENST00000394215.2_Silent_p.V462V|DENND1A_ENST00000473039.1_5'UTR|DENND1A_ENST00000373620.3_Silent_p.V492V|DENND1A_ENST00000394219.3_Silent_p.V460V	NM_020946.1	NP_065997.1	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A	492						cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|liver(2)|lung(18)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43						GTCCAAAGTGGACTGTGATTG	0.542000													16	17					0	0	1	0	0
MRAP	56246	broad.mit.edu	37	21	33684129	33684129	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr21:33684129G>A	ENST00000399784.2	+	5	528	c.341G>A	c.(340-342)gGg>gAg	p.G114E	MRAP_ENST00000339944.4_Intron|MRAP_ENST00000303645.5_Missense_Mutation_p.G114E|MRAP_ENST00000399786.3_Intron|URB1_ENST00000382751.3_3'UTR|MRAP_ENST00000497833.1_3'UTR	NM_178817.3	NP_848932.1	Q8TCY5	MRAP_HUMAN	melanocortin 2 receptor accessory protein	114					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|integral to membrane|perinuclear region of cytoplasm|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding			endometrium(1)|large_intestine(2)|lung(3)	6						GTGGAGCCAGGGAGCAGAACT	0.647000													13	15					0	0	1	0	0
SPATC1	375686	broad.mit.edu	37	8	145095681	145095681	+	Missense_Mutation	SNP	A	A	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:145095681A>C	ENST00000377470.3	+	3	1081	c.979A>C	c.(979-981)Acc>Ccc	p.T327P	SPATC1_ENST00000447830.2_Missense_Mutation_p.T327P	NM_198572.2	NP_940974.2	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	327										NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			cacctcccccaccacctcccc	0.667000													3	37					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	62023660	62023660	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:62023660C>T	ENST00000280772.1	-	6	823	c.632G>A	c.(631-633)cGa>cAa	p.R211Q	ANK3_ENST00000373827.2_Missense_Mutation_p.R205Q|ANK3_ENST00000503366.1_Missense_Mutation_p.R194Q	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	211					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GTCGTCTTTTCGGGCCGCGAT	0.547000													13	17					0	0	1	0	0
ZNF234	10780	broad.mit.edu	37	19	44661340	44661340	+	Missense_Mutation	SNP	C	C	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:44661340C>A	ENST00000426739.2	+	6	1429	c.1171C>A	c.(1171-1173)Cag>Aag	p.Q391K	ZNF234_ENST00000592437.1_Missense_Mutation_p.Q391K	NM_006630.2	NP_006621.1	Q14588	ZN234_HUMAN	zinc finger protein 234	391					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)	23		Prostate(69;0.0435)				TCAGGCCCATCAGGGAGTCCA	0.443000													7	16					0.000274275	0.00027493	1	1	0
FBN1	2200	broad.mit.edu	37	15	48704789	48704789	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:48704789C>T	ENST00000316623.5	-	65	8658	c.8203G>A	c.(8203-8205)Gaa>Aaa	p.E2735K	FBN1_ENST00000561429.1_5'UTR	NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	2735					heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GCATCAGTTTCGTTTGTGCTT	0.498000													35	55					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90074253	90074253	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:90074253G>A	ENST00000405460.2	+	63	12772	c.12676G>A	c.(12676-12678)Gat>Aat	p.D4226N		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	4226	Calx-beta 28.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GGCTTTGAACGATGACATTCC	0.403000													10	4					0	0	1	0	0
EYS	346007	broad.mit.edu	37	6	66044898	66044898	+	Missense_Mutation	SNP	A	A	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:66044898A>T	ENST00000503581.1	-	11	2278	c.1741T>A	c.(1741-1743)Tgt>Agt	p.C581S	EYS_ENST00000370616.2_Missense_Mutation_p.C581S|EYS_ENST00000393380.2_Missense_Mutation_p.C581S|EYS_ENST00000370618.3_Missense_Mutation_p.C581S|EYS_ENST00000370621.3_Missense_Mutation_p.C581S|EYS_ENST00000342421.5_Missense_Mutation_p.C581S	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	581	EGF-like 6.				response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						TCATCTTTACAAACAGCTTCA	0.318000													5	4					0	0	1	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133670158	133670158	+	Missense_Mutation	SNP	C	C	T	rs35799156		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:133670158C>T	ENST00000310926.4	-	6	1028	c.755G>A	c.(754-756)cGa>cAa	p.R252Q	SLCO2A1_ENST00000493729.1_Missense_Mutation_p.R176Q	NM_005630.2	NP_005621.2	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family, member 2A1	252					sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						TCCAATCCATCGGGGGTCACC	0.478000													21	31					0	0	1	0	0
CD1C	911	broad.mit.edu	37	1	158262068	158262068	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:158262068G>A	ENST00000368170.3	+	3	802	c.523G>A	c.(523-525)Gaa>Aaa	p.E175K		NM_001765.2	NP_001756.2	P29017	CD1C_HUMAN	CD1c molecule	175					antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			NS(1)|endometrium(3)|large_intestine(4)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	39	all_hematologic(112;0.0378)					AGGCGTCACAGAAACAGTGTA	0.463000													244	107					0	0	1	0	0
POLR2J4	84820	broad.mit.edu	37	7	44005877	44005877	+	RNA	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:44005877C>T	ENST00000427076.1	-	0	1317					NR_003655.2																						CCCAGGAAGTCGTTTCGGCTG	0.662000													4	12					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140208418	140208418	+	Nonsense_Mutation	SNP	G	G	T	rs149898673		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:140208418G>T	ENST00000529310.1	+	1	856	c.742G>T	c.(742-744)Gaa>Taa	p.E248*	PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Nonsense_Mutation_p.E248*|PCDHA4_ENST00000512229.2_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCTGAATACGAAGTAAGAAT	0.453000													3	102					1	1	1	1	0
GRID1	2894	broad.mit.edu	37	10	87898618	87898618	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:87898618G>A	ENST00000327946.7	-	4	769	c.684C>T	c.(682-684)atC>atT	p.I228I		NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	228						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	TGAGCAGCAGGATGGCGCGGC	0.597000										Multiple Myeloma(13;0.14)			60	62					0	0	1	0	0
APBB1IP	54518	broad.mit.edu	37	10	26830607	26830607	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:26830607T>C	ENST00000376236.4	+	11	1596	c.1141T>C	c.(1141-1143)Tgc>Cgc	p.C381R		NM_019043.3	NP_061916.3	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	381	PH.				blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(27)|skin(7)|upper_aerodigestive_tract(1)	45						CACTGACTATTGCTTTGTTTT	0.294000													8	7					0	0	1	0	0
STK11IP	114790	broad.mit.edu	37	2	220466127	220466127	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:220466127C>T	ENST00000456909.1	+	3	322	c.232C>T	c.(232-234)Ctc>Ttc	p.L78F	STK11IP_ENST00000295641.10_Missense_Mutation_p.L89F|STK11IP_ENST00000459692.1_3'UTR			Q8N1F8	S11IP_HUMAN	serine/threonine kinase 11 interacting protein	89					protein localization	cytoplasm	protein kinase binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	23		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCTTCAGTTTCTCTTCGATGT	0.547000													20	30					0	0	1	0	0
TTC5	91875	broad.mit.edu	37	14	20767021	20767021	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:20767021G>A	ENST00000258821.3	-	5	630	c.574C>T	c.(574-576)Ctt>Ttt	p.L192F		NM_138376.2	NP_612385.2	Q8N0Z6	TTC5_HUMAN	tetratricopeptide repeat domain 5	192					DNA repair	cytoplasm|nucleus	binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	15	all_cancers(95;0.00092)		Epithelial(56;1.1e-06)|all cancers(55;8.07e-06)	GBM - Glioblastoma multiforme(265;0.0106)		GAGAAGTAAAGGGAAAGATAT	0.418000													12	11					0	0	1	0	0
ZC3HAV1	56829	broad.mit.edu	37	7	138739986	138739986	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:138739986C>T	ENST00000242351.5	-	10	2468	c.2152G>A	c.(2152-2154)Gag>Aag	p.E718K	ZC3HAV1_ENST00000464606.1_Missense_Mutation_p.E840K	NM_020119.3	NP_064504.2	Q7Z2W4	ZCCHV_HUMAN	zinc finger CCCH-type, antiviral 1	718	PARP catalytic.				response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			cervix(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(4)|skin(1)	37						CAAAAGTCCTCCTGAGGACGA	0.403000													45	58					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31323136	31323136	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:31323136C>T	ENST00000265071.2	+	12	2359	c.2094C>T	c.(2092-2094)ttC>ttT	p.F698F		NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	698					adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						AAGCCCTTTTCCTACCCCGAC	0.522000													26	23					0	0	1	0	0
IGHE	3497	broad.mit.edu	37	14	106067994	106067994	+	RNA	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:106067994G>A	ENST00000390540.2	-	0	391																											CCAGAGTCACGGAGGTGGCAT	0.607000													13	19					0	0	1	0	0
SYNDIG1L	646658	broad.mit.edu	37	14	74876343	74876343	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:74876343C>T	ENST00000331628.3	-	2	352	c.105G>A	c.(103-105)caG>caA	p.Q35Q	SYNDIG1L_ENST00000554823.1_Silent_p.Q35Q	NM_001105579.1	NP_001099049.1	A6NDD5	SYN1L_HUMAN	synapse differentiation inducing 1-like	35					response to biotic stimulus	Golgi apparatus|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|lung(8)|pancreas(1)|prostate(1)|skin(1)	14						AGAGCTTTTCCTGGCAGGACC	0.662000													17	26					0	0	1	0	0
SPIB	6689	broad.mit.edu	37	19	50926222	50926222	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:50926222C>T	ENST00000595883.1	+	4	292	c.267C>T	c.(265-267)ctC>ctT	p.L89L	SPIB_ENST00000439922.2_Intron|SPIB_ENST00000270632.7_Silent_p.L89L|SPIB_ENST00000596074.1_Intron|SPIB_ENST00000597855.1_Silent_p.L89L	NM_001243999.1|NM_001244000.1|NM_003121.4	NP_001230928.1|NP_001230929.1|NP_003112.2	Q01892	SPIB_HUMAN	Spi-B transcription factor (Spi-1/PU.1 related)	89					regulation of transcription from RNA polymerase II promoter	cytoplasm|microtubule cytoskeleton|nucleus	sequence-specific DNA binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(8)	14		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		CAGGGAACCTCGAACTGGCCC	0.647000													32	87					0	0	1	0	0
MIB1	57534	broad.mit.edu	37	18	19359527	19359527	+	Silent	SNP	T	T	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr18:19359527T>C	ENST00000261537.6	+	6	1053	c.789T>C	c.(787-789)tcT>tcC	p.S263S	MIB1_ENST00000578646.1_3'UTR	NM_020774.2	NP_065825.1	Q86YT6	MIB1_HUMAN	mindbomb E3 ubiquitin protein ligase 1	263					Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|ovary(5)	27			STAD - Stomach adenocarcinoma(5;0.212)			TTGTACAGTCTTTGCAGCATG	0.428000													93	99					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139890152	139890152	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:139890152G>A	ENST00000303045.6	-	3	945	c.499C>T	c.(499-501)Cgc>Tgc	p.R167C	COL22A1_ENST00000435777.1_Missense_Mutation_p.R167C	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	167	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			ATGCCAGCGCGGTGGGCTGCC	0.716000										HNSCC(7;0.00092)			4	29					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8465571	8465571	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:8465571G>A	ENST00000381196.4	-	29	4152	c.3609C>T	c.(3607-3609)ttC>ttT	p.F1203F	PTPRD_ENST00000537002.1_Silent_p.F789F|PTPRD_ENST00000360074.4_Silent_p.F1190F|PTPRD_ENST00000397611.3_Silent_p.F789F|PTPRD_ENST00000486161.1_Silent_p.F792F|PTPRD_ENST00000540109.1_Silent_p.F1203F|PTPRD_ENST00000355233.5_Silent_p.F792F|PTPRD_ENST00000397617.3_Silent_p.F782F|PTPRD_ENST00000356435.5_Silent_p.F1203F|PTPRD_ENST00000397606.3_Silent_p.F782F|PTPRD_ENST00000358503.5_Silent_p.F1181F	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1203					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CCCCCAGGGTGAACTCAGTGG	0.428000										TSP Lung(15;0.13)			16	28					0	0	1	0	0
UNK	85451	broad.mit.edu	37	17	73815826	73815826	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:73815826C>T	ENST00000293218.3	+	13	1836	c.1836C>T	c.(1834-1836)ttC>ttT	p.F612F	RP11-552F3.4_ENST00000586808.1_RNA|UNK_ENST00000589666.1_Silent_p.F536F			Q9C0B0	UNK_HUMAN	unkempt family zinc finger	536							nucleic acid binding|zinc ion binding			cervix(3)|endometrium(8)|kidney(2)|large_intestine(5)|lung(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	25			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			AGAAGACTTTCGATAACAGCA	0.602000													38	80					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20496753	20496753	+	RNA	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:20496753C>T	ENST00000555186.1	+	0	806					NR_038836.1																						TTCTTTGAGTCTGTTTTTTAT	0.378000													2	5					0	0	1	0	0
CSRNP1	64651	broad.mit.edu	37	3	39184611	39184611	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:39184611G>A	ENST00000273153.5	-	5	1882	c.1705C>T	c.(1705-1707)Ccc>Tcc	p.P569S	CSRNP1_ENST00000514182.1_Missense_Mutation_p.P569S	NM_033027.3	NP_149016.2	Q96S65	CSRN1_HUMAN	cysteine-serine-rich nuclear protein 1	569					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(3)|endometrium(4)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|skin(3)	24						TCAATAAAGGGATCTAGGGCT	0.592000													22	26					0	0	1	0	0
AZU1	566	broad.mit.edu	37	19	830930	830930	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:830930G>A	ENST00000233997.2	+	4	604	c.583G>A	c.(583-585)Ggc>Agc	p.G195S		NM_001700.3	NP_001691.1	P20160	CAP7_HUMAN	azurocidin 1	195	Peptidase S1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cellular extravasation|defense response to Gram-negative bacterium|glial cell migration|induction of positive chemotaxis|inflammatory response|macrophage chemotaxis|microglial cell activation|monocyte activation|positive regulation of cell adhesion|positive regulation of fractalkine biosynthetic process|positive regulation of interleukin-1 beta biosynthetic process|positive regulation of MHC class II biosynthetic process|positive regulation of phagocytosis|positive regulation of tumor necrosis factor biosynthetic process|proteolysis|regulation of vascular permeability	azurophil granule|extracellular region	heparin binding|serine-type endopeptidase activity|toxin binding			NS(1)|endometrium(1)|kidney(1)|lung(4)|pancreas(1)|upper_aerodigestive_tract(2)	10		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGCCGCGGTGGCATCTGCAA	0.637000													16	24					0	0	1	0	0
GABRA4	2557	broad.mit.edu	37	4	46973212	46973212	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:46973212C>T	ENST00000264318.3	-	7	1744	c.762G>A	c.(760-762)cgG>cgA	p.R254R		NM_000809.3|NM_001204266.1|NM_001204267.1	NP_000800.2|NP_001191195.1|NP_001191196.1	P48169	GBRA4_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 4	254					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AACCCATCTTCCGTCTGAGGT	0.378000													2	0					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228884600	228884600	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:228884600G>A	ENST00000392056.3	-	7	1016	c.970C>T	c.(970-972)Cat>Tat	p.H324Y	SPHKAP_ENST00000344657.5_Missense_Mutation_p.H324Y	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	324						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GCTTCTGAATGATAATAATGT	0.413000													39	106					0	0	1	0	0
MMP20	9313	broad.mit.edu	37	11	102448155	102448155	+	Missense_Mutation	SNP	A	A	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:102448155A>T	ENST00000260228.2	-	10	1366	c.1354T>A	c.(1354-1356)Tac>Aac	p.Y452N		NM_004771.3	NP_004762.2	O60882	MMP20_HUMAN	matrix metallopeptidase 20	452	Hemopexin-like 4.				proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		AAGTAAATGTAGCCTAAAAGA	0.363000													24	20					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215848073	215848073	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:215848073C>T	ENST00000366943.2	-	63	13566	c.13180G>A	c.(13180-13182)Gat>Aat	p.D4394N	USH2A_ENST00000307340.3_Missense_Mutation_p.D4394N			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4394	Fibronectin type-III 29.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TCTTTATTATCATATCTAACT	0.478000										HNSCC(13;0.011)			29	8					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3224730	3224730	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:3224730G>A	ENST00000602557.1	-	21	3497	c.2942C>T	c.(2941-2943)tCc>tTc	p.S981F	CSMD1_ENST00000537824.1_Missense_Mutation_p.S980F|CSMD1_ENST00000400186.3_Missense_Mutation_p.S981F|CSMD1_ENST00000602723.1_Missense_Mutation_p.S981F|CSMD1_ENST00000539096.1_Missense_Mutation_p.S980F|CSMD1_ENST00000520002.1_Missense_Mutation_p.S981F|CSMD1_ENST00000542608.1_Missense_Mutation_p.S980F			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	981	CUB 6.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ATAGTCGTGGGAACTCTCAAG	0.537000													5	1					0	0	1	0	0
PALD1	27143	broad.mit.edu	37	10	72297608	72297608	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:72297608G>A	ENST00000263563.6	+	11	1537	c.1269G>A	c.(1267-1269)tgG>tgA	p.W423*		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		GGGCGCTGTGGAGCCTGGAGC	0.612000													37	48					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62288660	62288660	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:62288660C>T	ENST00000371158.2	+	15	1841	c.1727C>T	c.(1726-1728)tCc>tTc	p.S576F	INADL_ENST00000316485.6_Missense_Mutation_p.S576F	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	576	PDZ 4.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						GAAGTGGATTCCTTTGATGGG	0.428000													63	85					0	0	1	0	0
PTPN13	5783	broad.mit.edu	37	4	87726520	87726520	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:87726520C>T	ENST00000436978.1	+	44	7238	c.6758C>T	c.(6757-6759)cCc>cTc	p.P2253L	PTPN13_ENST00000427191.2_Missense_Mutation_p.P2229L|PTPN13_ENST00000411767.2_Missense_Mutation_p.P2248L|PTPN13_ENST00000511467.1_Missense_Mutation_p.P2253L|PTPN13_ENST00000316707.6_Missense_Mutation_p.P2057L	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	2248	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		AATATACTTCCCTGTAAGTTC	0.308000													5	3					0	0	1	0	0
OR10G8	219869	broad.mit.edu	37	11	123901027	123901027	+	Missense_Mutation	SNP	A	A	G	rs148074790	byFrequency	TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:123901027A>G	ENST00000431524.1	+	1	731	c.698A>G	c.(697-699)aAg>aGg	p.K233R		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	233					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TCAGAGGGGAAGCACAGAGCC	0.547000													3	16					0	0	1	0	0
AK8	158067	broad.mit.edu	37	9	135702433	135702433	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:135702433G>A	ENST00000298545.3	-	8	1086	c.565C>T	c.(565-567)Cac>Tac	p.H189Y	AK8_ENST00000477396.1_5'UTR	NM_152572.2	NP_689785.1	Q96MA6	KAD8_HUMAN	adenylate kinase 8	189						cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			NS(1)|kidney(2)|large_intestine(4)|lung(11)|pancreas(2)|prostate(1)|urinary_tract(2)	23						AAGGTGGTGTGATAAATCTCT	0.567000													44	64					0	0	1	0	0
BPTF	2186	broad.mit.edu	37	17	65940425	65940425	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:65940425C>T	ENST00000321892.4	+	22	7076	c.7015C>T	c.(7015-7017)Cca>Tca	p.P2339S	BPTF_ENST00000306378.6_Missense_Mutation_p.P2213S|BPTF_ENST00000335221.5_Missense_Mutation_p.P2339S|BPTF_ENST00000424123.3_Missense_Mutation_p.P2200S|BPTF_ENST00000577770.1_3'UTR			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	2339	Thr-rich.				brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			CCTCTTTACCCCATTGGCAAC	0.537000													37	101					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49693591	49693591	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:49693591C>T	ENST00000296452.4	+	5	6716	c.6602C>T	c.(6601-6603)cCa>cTa	p.P2201L		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	2201					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		ATCAATACCCCAATTGCTGCA	0.587000													19	36					0	0	1	0	0
TNIK	23043	broad.mit.edu	37	3	170783999	170783999	+	Missense_Mutation	SNP	A	A	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:170783999A>T	ENST00000436636.2	-	32	4320	c.3976T>A	c.(3976-3978)Ttt>Att	p.F1326I	TNIK_ENST00000475336.1_Missense_Mutation_p.F1234I|TNIK_ENST00000488470.1_Missense_Mutation_p.F1271I|TNIK_ENST00000538048.1_Missense_Mutation_p.F1278I|TNIK_ENST00000357327.5_Missense_Mutation_p.F1297I|TNIK_ENST00000369326.5_Missense_Mutation_p.F1304I|TNIK_ENST00000284483.8_Missense_Mutation_p.F1318I|TNIK_ENST00000341852.6_Missense_Mutation_p.F1242I|TNIK_ENST00000470834.1_Missense_Mutation_p.F1289I|TNIK_ENST00000460047.1_Missense_Mutation_p.F1263I	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	1326	CNH.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TCACATAGAAACTTTAACCTT	0.398000													13	25					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136566687	136566687	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:136566687C>T	ENST00000264162.2	-	8	3240	c.3230G>A	c.(3229-3231)gGg>gAg	p.G1077E		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1077	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GGGAAATTCCCCTGAGCCATA	0.512000													13	18					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129233282	129233282	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:129233282G>A	ENST00000296266.3	+	26	3383	c.3191G>A	c.(3190-3192)aGg>aAg	p.R1064K	IFT122_ENST00000349441.2_Missense_Mutation_p.R903K|IFT122_ENST00000348417.2_Missense_Mutation_p.R1013K|IFT122_ENST00000347300.2_Missense_Mutation_p.R954K|IFT122_ENST00000507564.1_Missense_Mutation_p.R1006K|IFT122_ENST00000504021.1_Missense_Mutation_p.R890K|IFT122_ENST00000440957.2_Missense_Mutation_p.R804K|IFT122_ENST00000431818.2_Missense_Mutation_p.R863K	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	1013					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						GGTGCCTACAGGCTGGCCCGG	0.607000													28	26					0	0	1	0	0
ALDH4A1	8659	broad.mit.edu	37	1	19201979	19201979	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:19201979G>A	ENST00000375341.3	-	13	1614	c.1357C>T	c.(1357-1359)Ctg>Ttg	p.L453L	ALDH4A1_ENST00000290597.5_Silent_p.L453L|ALDH4A1_ENST00000538839.1_Silent_p.L402L|ALDH4A1_ENST00000538309.1_Silent_p.L393L|RP13-279N23.2_ENST00000494072.3_3'UTR	NM_003748.3	NP_003739.2	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4 family, member A1	453					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity			cervix(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(1)	15		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	TACACAGACAGTACAGGCCCG	0.637000											OREG0013164	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	68					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149473471	149473471	+	RNA	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:149473471G>A	ENST00000378016.2	+	0	87							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TCCGTGTGGAGGAGGAAGTGG	0.642000													9	16					0	0	1	0	0
SF3B1	23451	broad.mit.edu	37	2	198288628	198288628	+	Silent	SNP	G	G	A	rs143444124	by1000genomes	TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:198288628G>A	ENST00000335508.5	-	2	190	c.99C>T	c.(97-99)ctC>ctT	p.L33L	SF3B1_ENST00000409915.4_Silent_p.L33L|SF3B1_ENST00000414963.2_Silent_p.L33L|SF3B1_ENST00000487698.1_Silent_p.L33L	NM_012433.2	NP_036565.2	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1, 155kDa	33					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			NS(35)|breast(10)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(524)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|pancreas(4)|prostate(6)|salivary_gland(1)|skin(4)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	633			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CTGTAGAATCGAGGCCCACTC	0.393000			Mis		myelodysplastic syndrome								17	37					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	71029486	71029486	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:71029486C>T	ENST00000334414.6	-	2	460	c.416G>A	c.(415-417)gGa>gAa	p.G139E	PTPRB_ENST00000538174.2_5'UTR|PTPRB_ENST00000550358.1_Missense_Mutation_p.G139E|PTPRB_ENST00000551525.1_Missense_Mutation_p.G138E	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	0	Fibronectin type-III 2.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GACCAGTTTTCCCTCCTTGTT	0.413000													7	7					0	0	1	0	0
LINC00674	100499466	broad.mit.edu	37	17	66110654	66110654	+	RNA	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:66110654G>A	ENST00000435469.2	+	0	208																											CTTGACTACGGAGGGGTTGCC	0.393000													11	14					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	55052249	55052249	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:55052249G>A	ENST00000474759.1	+	35	2940	c.2892G>A	c.(2890-2892)caG>caA	p.Q964Q	CACNA2D3_ENST00000415676.2_Silent_p.Q964Q|CACNA2D3_ENST00000490478.1_Silent_p.Q870Q|CACNA2D3_ENST00000478261.1_3'UTR|CACNA2D3_ENST00000288197.5_Silent_p.Q964Q	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	964						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		AATTGAAACAGACCCTGGAGC	0.468000													4	5					0	0	1	0	0
HCAR3	8843	broad.mit.edu	37	12	123200954	123200954	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:123200954G>A	ENST00000528880.2	-	1	485	c.331C>T	c.(331-333)Cgc>Tgc	p.R111C	HCAR1_ENST00000356987.2_Intron	NM_006018.2	NP_006009.2	P49019	HCAR3_HUMAN	hydroxycarboxylic acid receptor 3	111						integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	9					Mepenzolate(DB04843)|Niacin(DB00627)	CTGCCCTGGCGGTTCATGGCA	0.567000													36	23					0	0	1	0	0
SAMD14	201191	broad.mit.edu	37	17	48191601	48191601	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:48191601C>T	ENST00000330175.4	-	8	1209	c.892G>A	c.(892-894)Gag>Aag	p.E298K	SAMD14_ENST00000503131.1_Missense_Mutation_p.E326K	NM_001257359.1	NP_001244288.1	Q8IZD0	SAM14_HUMAN	sterile alpha motif domain containing 14	298										breast(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(3)|prostate(1)|urinary_tract(1)	15						CATTTGGCCTCCTGCCAGGGC	0.592000													32	29					0	0	1	0	0
ATF6	22926	broad.mit.edu	37	1	161833035	161833035	+	Missense_Mutation	SNP	G	G	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:161833035G>C	ENST00000367942.3	+	14	1719	c.1652G>C	c.(1651-1653)aGt>aCt	p.S551T		NM_007348.3	NP_031374.2	P18850	ATF6A_HUMAN	activating transcription factor 6	551					positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(14)|ovary(3)|skin(1)|stomach(1)	34	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			TCACCCAGAAGTTATCAAGAC	0.353000													36	126					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2855630	2855630	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:2855630C>T	ENST00000602557.1	-	55	8838	c.8283G>A	c.(8281-8283)gtG>gtA	p.V2761V	CSMD1_ENST00000537824.1_Silent_p.V2760V|CSMD1_ENST00000400186.3_Silent_p.V2703V|CSMD1_ENST00000602723.1_Silent_p.V2703V|CSMD1_ENST00000520002.1_Silent_p.V2761V|CSMD1_ENST00000542608.1_Silent_p.V2702V			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2761	Sushi 19.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AGGTGAAATTCACGACATCAT	0.557000													26	8					0	0	1	0	0
CHL1	10752	broad.mit.edu	37	3	382568	382568	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:382568C>T	ENST00000256509.2	+	6	1119	c.477C>T	c.(475-477)ctC>ctT	p.L159L	CHL1_ENST00000397491.2_Silent_p.L159L	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	159	Ig-like C2-type 2.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CCAAAGGCCTCCCACCTTTAC	0.393000													16	19					0	0	1	0	0
KCNJ15	3772	broad.mit.edu	37	21	39671687	39671687	+	Silent	SNP	C	C	T	rs140458855		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr21:39671687C>T	ENST00000398930.1	+	4	858	c.504C>T	c.(502-504)atC>atT	p.I168I	KCNJ15_ENST00000398938.2_Silent_p.I168I|KCNJ15_ENST00000398932.1_Silent_p.I168I|KCNJ15_ENST00000398934.1_Silent_p.I168I|KCNJ15_ENST00000328656.3_Silent_p.I168I			Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 15	168					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity	p.I168I(1)		autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	24						TGGCCAAAATCGCCAGACCCA	0.502000													22	31					0	0	1	0	0
NEIL3	55247	broad.mit.edu	37	4	178272600	178272600	+	Silent	SNP	C	C	T	rs138744063		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:178272600C>T	ENST00000264596.3	+	7	1054	c.936C>T	c.(934-936)tcC>tcT	p.S312S	RP11-376O6.2_ENST00000506895.1_RNA	NM_018248.2	NP_060718.2	Q8TAT5	NEIL3_HUMAN	nei endonuclease VIII-like 3 (E. coli)	312					base-excision repair|nucleotide-excision repair	nucleus	bubble DNA binding|damaged DNA binding|DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA binding|single-stranded DNA binding|zinc ion binding	p.S312S(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.164)		all cancers(43;1.96e-23)|Epithelial(43;2.52e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.89e-11)|GBM - Glioblastoma multiforme(59;9.49e-05)|Colorectal(24;0.00013)|COAD - Colon adenocarcinoma(29;0.000696)|STAD - Stomach adenocarcinoma(60;0.00308)|LUSC - Lung squamous cell carcinoma(193;0.0398)|READ - Rectum adenocarcinoma(43;0.191)		TTATGGACTCCGTGGCTCGGA	0.413000								Base excision repair (BER), DNA glycosylases					43	59					0	0	1	0	0
MYOF	26509	broad.mit.edu	37	10	95119734	95119734	+	Splice_Site	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:95119734G>A	ENST00000371501.4	-	29	3098	c.2974_splice	c.e29-1	p.G992_splice	MYOF_ENST00000359263.4_Splice_Site_p.G992_splice|MYOF_ENST00000371502.4_Splice_Site_p.G992_splice|MYOF_ENST00000358334.5_Splice_Site_p.G979_splice			Q9NZM1	MYOF_HUMAN	myoferlin	992					blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						CATATTCCCAGCCTGGAACAG	0.478000													29	52					0	0	1	0	0
C1orf172	126695	broad.mit.edu	37	1	27278292	27278292	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:27278292C>T	ENST00000320567.5	-	2	668	c.580G>A	c.(580-582)Gat>Aat	p.D194N		NM_152365.2	NP_689578.2	Q8NAX2	CA172_HUMAN	chromosome 1 open reading frame 172	194										NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.37e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.22e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		GGTGGGGGATCGGCCAGTGGC	0.617000													30	38					0	0	1	0	0
DAND5	199699	broad.mit.edu	37	19	13084348	13084348	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:13084348C>T	ENST00000317060.2	+	2	649	c.470C>T	c.(469-471)cCc>cTc	p.P157L	DAND5_ENST00000585548.1_3'UTR	NM_152654.2	NP_689867.1	Q8N907	DAND5_HUMAN	DAN domain family member 5, BMP antagonist	157	CTCK.					extracellular region				kidney(2)|lung(3)|ovary(1)	6			OV - Ovarian serous cystadenocarcinoma(19;1.87e-18)			CGTTGGGCACCCGTGGTCCTG	0.592000													64	90					0	0	1	0	0
NMBR	4829	broad.mit.edu	37	6	142396923	142396923	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:142396923G>A	ENST00000258042.1	-	3	1175	c.1035C>T	c.(1033-1035)tcC>tcT	p.S345S	NMBR_ENST00000480652.1_5'UTR	NM_002511.2	NP_002502.2	P28336	NMBR_HUMAN	neuromedin B receptor	345					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			breast(2)|central_nervous_system(3)|endometrium(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		TCTCTTGATAGGACTTCCTCC	0.453000													19	22					0	0	1	0	0
KCNT1	57582	broad.mit.edu	37	9	138650353	138650353	+	Splice_Site	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:138650353G>A	ENST00000298480.5	+	10	927	c.854_splice	c.e10+1	p.G285_splice	KCNT1_ENST00000487664.1_Splice_Site_p.G237_splice|KCNT1_ENST00000488444.2_Splice_Site_p.G266_splice|KCNT1_ENST00000371757.2_Splice_Site_p.G285_splice|KCNT1_ENST00000490355.2_Splice_Site_p.G266_splice|KCNT1_ENST00000486577.2_Splice_Site_p.G246_splice|KCNT1_ENST00000263604.3_Splice_Site_p.G266_splice|KCNT1_ENST00000491806.2_Splice_Site_p.G252_splice			B7ZVY4	B7ZVY4_HUMAN	potassium channel, subfamily T, member 1	285						membrane	binding|calcium-activated potassium channel activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		CGTTTTCACGGGGTGAGTGCC	0.612000													45	48					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31372470	31372470	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:31372470G>A	ENST00000268296.4	+	9	1069	c.948G>A	c.(946-948)gtG>gtA	p.V316V	ITGAX_ENST00000562522.1_Silent_p.V316V	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	316	VWFA.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						TATTTAAAGTGGAGGACTTTG	0.418000													63	46					0	0	1	0	0
ENC1	8507	broad.mit.edu	37	5	73931247	73931247	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:73931247G>A	ENST00000302351.4	-	2	2194	c.1064C>T	c.(1063-1065)tCa>tTa	p.S355L	ENC1_ENST00000537006.1_Missense_Mutation_p.S355L|ENC1_ENST00000510316.1_Missense_Mutation_p.S282L	NM_003633.3	NP_003624.1	O14682	ENC1_HUMAN	ectodermal-neural cortex 1 (with BTB domain)	355					nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	20		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)		GACATCTTTTGAGACCCCATT	0.547000													164	126					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	69009287	69009287	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:69009287G>A	ENST00000288368.4	+	22	2681	c.2404G>A	c.(2404-2406)Gat>Aat	p.D802N	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	802					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						GGCCATCATTGATGGGAAGAA	0.408000													76	25					0	0	1	0	0
ZFP64	55734	broad.mit.edu	37	20	50769650	50769650	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:50769650G>A	ENST00000216923.4	-	6	1430	c.1081C>T	c.(1081-1083)Cac>Tac	p.H361Y	ZFP64_ENST00000346617.4_Missense_Mutation_p.H307Y|ZFP64_ENST00000371518.2_Intron|ZFP64_ENST00000361387.2_Intron|ZFP64_ENST00000371515.4_Missense_Mutation_p.H359Y|ZFP64_ENST00000477786.1_Intron	NM_018197.2|NM_199426.1	NP_060667.2|NP_955458.1	Q9NPA5	ZF64A_HUMAN	ZFP64 zinc finger protein	361					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(5)|large_intestine(8)|lung(11)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	33						ATACGCTCGTGGATGCGCAGG	0.597000													46	75					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11076324	11076324	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:11076324G>A	ENST00000287766.4	+	15	2056	c.1635G>A	c.(1633-1635)atG>atA	p.M545I	SLC6A1_ENST00000536032.1_Missense_Mutation_p.M367I	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	545					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	TGTCTTCCATGGTCCTCATCC	0.552000													42	59					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113950937	113950937	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:113950937C>T	ENST00000245796.6	+	8	2217	c.2022C>T	c.(2020-2022)ttC>ttT	p.F674F	PSD4_ENST00000441564.2_Silent_p.F646F	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	674	SEC7.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CGGGGATCTTCCCCTCAGTAG	0.582000													29	24					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34087782	34087782	+	Missense_Mutation	SNP	G	G	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:34087782G>C	ENST00000373381.4	-	37	5988	c.5812C>G	c.(5812-5814)Cac>Gac	p.H1938D	CSMD2_ENST00000373380.1_Missense_Mutation_p.H811D|CSMD2_ENST00000373388.2_Missense_Mutation_p.H37D|CSMD2_ENST00000373377.1_Missense_Mutation_p.H37D	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1898	Sushi 11.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TACTCCAAGTGGAAGCCAGCT	0.517000													79	108					0	0	1	0	0
SAGE1	55511	broad.mit.edu	37	X	134988650	134988650	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chrX:134988650C>T	ENST00000535938.1	+	7	843	c.676C>T	c.(676-678)Cga>Tga	p.R226*	SAGE1_ENST00000370709.3_Nonsense_Mutation_p.R226*|SAGE1_ENST00000537770.1_Intron|SAGE1_ENST00000324447.3_Nonsense_Mutation_p.R226*	NM_018666.2	NP_061136.2	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	226										breast(5)|endometrium(5)|large_intestine(10)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	55	Acute lymphoblastic leukemia(192;0.000127)					GTTGACTCTTCGACCACGGCG	0.428000													40	54					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108488310	108488310	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:108488310C>T	ENST00000408999.3	+	20	3927	c.3850C>T	c.(3850-3852)Cat>Tat	p.H1284Y	RGPD4_ENST00000354986.4_Missense_Mutation_p.H1284Y	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1284					intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						AAATCTTTTCCATTTTGGTGA	0.408000													49	59					0	0	1	0	0
SLC35F4	341880	broad.mit.edu	37	14	58063597	58063597	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:58063597C>T	ENST00000339762.6	-	1	18	c.19G>A	c.(19-21)Gat>Aat	p.D7N	SLC35F4_ENST00000557430.1_Intron|SLC35F4_ENST00000556826.1_Intron|SLC35F4_ENST00000554729.1_5'UTR					solute carrier family 35, member F4											breast(1)|endometrium(4)|large_intestine(3)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TGGAAGAGATCCAAGAGTAGT	0.463000													12	17					0	0	1	0	0
TRMT44	152992	broad.mit.edu	37	4	8469678	8469678	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:8469678C>T	ENST00000389737.4	+	9	1532	c.1532C>T	c.(1531-1533)tCc>tTc	p.S511F	TRMT44_ENST00000513449.2_Missense_Mutation_p.S270F	NM_152544.2	NP_689757.2			tRNA methyltransferase 44 homolog (S. cerevisiae)																		TACCCTTCCTCCAGAGAAGCT	0.507000													34	37					0	0	1	0	0
CD177	57126	broad.mit.edu	37	19	43859932	43859932	+	RNA	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:43859932G>A	ENST00000378009.4	+	0	541				CD177_ENST00000607517.1_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				CAGGCTCAGGGGAGGTAAGCC	0.592000													24	39					0	0	1	0	0
SLC34A2	10568	broad.mit.edu	37	4	25678325	25678325	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:25678325G>A	ENST00000382051.3	+	13	2077	c.2027G>A	c.(2026-2028)gGt>gAt	p.G676D	SLC34A2_ENST00000504570.1_Missense_Mutation_p.G675D|SLC34A2_ENST00000503434.1_Missense_Mutation_p.G675D	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	676					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				GAGGCTCAGGGTGAGGTCCCT	0.577000			T	ROS1	NSCLC								25	33					0	0	1	0	0
GBP6	163351	broad.mit.edu	37	1	89848403	89848403	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:89848403G>A	ENST00000370456.4	+	8	1426	c.1333G>A	c.(1333-1335)Gac>Aac	p.D445N	GBP6_ENST00000535065.1_Missense_Mutation_p.D315N	NM_198460.2	NP_940862.2	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	445							GTP binding|GTPase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		GATTGAACAGGACTATTGGCA	0.463000													19	15					0	0	1	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68242764	68242764	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:68242764G>A	ENST00000347230.4	-	26	5172	c.5034C>T	c.(5032-5034)ccC>ccT	p.P1678P	ZFYVE26_ENST00000555452.1_Silent_p.P1678P	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1678					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		GCATGAACAGGGGGTTAGAGG	0.527000													53	74					0	0	1	0	0
DVL2	1856	broad.mit.edu	37	17	7132319	7132319	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:7132319G>A	ENST00000005340.5	-	9	1285	c.1003C>T	c.(1003-1005)Cgg>Tgg	p.R335W	DVL2_ENST00000575458.1_Missense_Mutation_p.R329W	NM_004422.2	NP_004413.1	O14641	DVL2_HUMAN	dishevelled segment polarity protein 2	335	PDZ.				canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|intracellular signal transduction|neural tube closure|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|segment specification|transcription from RNA polymerase II promoter	cytosol|nucleus|plasma membrane	frizzled binding|identical protein binding|signal transducer activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(7)|skin(1)	25						CTCAGCACCCGCACAGCGTCA	0.532000													3	47					0	0	1	0	0
APBB1	322	broad.mit.edu	37	11	6425049	6425049	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:6425049G>A	ENST00000389906.2	-	3	824	c.725C>T	c.(724-726)tCc>tTc	p.S242F	APBB1_ENST00000530885.1_Missense_Mutation_p.S22F|APBB1_ENST00000311051.3_Missense_Mutation_p.S242F|APBB1_ENST00000533407.1_5'UTR|APBB1_ENST00000299402.6_Missense_Mutation_p.S242F	NM_001257325.1	NP_001244254.1	O00213	APBB1_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	242					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding	p.S242F(1)		breast(4)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|prostate(2)|skin(1)|urinary_tract(1)	24		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		GTTCCAGAAGGAATCTGCCAG	0.602000													16	28					0	0	1	0	0
GDI2	2665	broad.mit.edu	37	10	5836878	5836878	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:5836878G>A	ENST00000380191.4	-	4	648	c.358C>T	c.(358-360)Cct>Tct	p.P120S	GDI2_ENST00000380132.4_Missense_Mutation_p.P124S|GDI2_ENST00000380181.3_Intron	NM_001115156.1|NM_001494.3	NP_001108628.1|NP_001485.2	P50395	GDIB_HUMAN	GDP dissociation inhibitor 2	120					protein transport|small GTPase mediated signal transduction	cell surface|cytosol|membrane	protein binding|Rab GDP-dissociation inhibitor activity			NS(1)|breast(1)|large_intestine(1)|lung(6)|urinary_tract(1)	10						TCAGTGGAAGGAACCTTGTAG	0.368000													17	16					0	0	1	0	0
NDUFA13	51079	broad.mit.edu	37	19	19627027	19627027	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:19627027G>A	ENST00000252576.5	+	1	229	c.229G>A	c.(229-231)Gaa>Aaa	p.E77K	NDUFA13_ENST00000507754.3_5'UTR	NM_015965.6	NP_057049.5			NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13											endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)	12						CCCGGGACCGGAAGTGTGGGA	0.622000													26	41					0	0	1	0	0
IGHV3-64	28414	broad.mit.edu	37	14	107113794	107113794	+	RNA	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:107113794G>A	ENST00000454421.2	-	0	377																											CCCATTTGAAGATACAGCGTG	0.473000													97	125					0	0	1	0	0
FCRLA	84824	broad.mit.edu	37	1	161683045	161683045	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:161683045C>T	ENST00000367959.2	+	6	1266	c.1024C>T	c.(1024-1026)Cac>Tac	p.H342Y	FCRLA_ENST00000236938.6_Missense_Mutation_p.H336Y|FCRLA_ENST00000367949.2_Missense_Mutation_p.H152Y|FCRLA_ENST00000367950.1_Missense_Mutation_p.H112Y|FCRLA_ENST00000294796.4_Missense_Mutation_p.H185Y|FCRLA_ENST00000367953.3_Missense_Mutation_p.H325Y|FCRLA_ENST00000367957.2_Missense_Mutation_p.H196Y|FCRLA_ENST00000350710.3_Missense_Mutation_p.H101Y|FCRLA_ENST00000309691.6_Missense_Mutation_p.H230Y|FCRLA_ENST00000546024.1_Missense_Mutation_p.H247Y|FCRLA_ENST00000540926.1_Missense_Mutation_p.H325Y|FCRLA_ENST00000540521.1_Missense_Mutation_p.H202Y|FCRLA_ENST00000349527.4_Missense_Mutation_p.H224Y|FCRLA_ENST00000470841.1_3'UTR	NM_001184866.1	NP_001171795.1	Q7L513	FCRLA_HUMAN	Fc receptor-like A	319					cell differentiation	cytoplasm|extracellular region		p.H319Y(1)		breast(1)|kidney(12)|large_intestine(4)|lung(13)|prostate(1)|skin(2)|stomach(1)	34	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			TCATCTGTATCACCAGATGGG	0.577000													17	46					0	0	1	0	0
ZNF234	10780	broad.mit.edu	37	19	44661338	44661338	+	Missense_Mutation	SNP	A	A	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:44661338A>T	ENST00000426739.2	+	6	1427	c.1169A>T	c.(1168-1170)cAt>cTt	p.H390L	ZNF234_ENST00000592437.1_Missense_Mutation_p.H390L	NM_006630.2	NP_006621.1	Q14588	ZN234_HUMAN	zinc finger protein 234	390					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)	23		Prostate(69;0.0435)				TTTCAGGCCCATCAGGGAGTC	0.438000													7	16					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94411922	94411922	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:94411922C>T	ENST00000282020.4	+	12	2249	c.1991C>T	c.(1990-1992)tCc>tTc	p.S664F	GRID2_ENST00000510992.1_Missense_Mutation_p.S569F	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	664					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	ATTGAAAGTTCCATCCAGTAA	0.393000													4	3					0	0	1	0	0
GPRC5C	55890	broad.mit.edu	37	17	72436695	72436695	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:72436695C>T	ENST00000392627.1	+	2	2041	c.915C>T	c.(913-915)atC>atT	p.I305I	GPRC5C_ENST00000342648.5_Intron|GPRC5C_ENST00000481232.1_Intron|GPRC5C_ENST00000392629.2_Silent_p.I272I	NM_022036.2	NP_071319.2	Q9NQ84	GPC5C_HUMAN	G protein-coupled receptor, family C, group 5, member C	260						cytoplasmic vesicle membrane|integral to plasma membrane	G-protein coupled receptor activity|protein binding			central_nervous_system(1)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	17						TGGTGTGGATCGTCATGTATA	0.622000													41	82					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55541525	55541525	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:55541525G>A	ENST00000220676.1	+	4	5231	c.5083G>A	c.(5083-5085)Gaa>Aaa	p.E1695K		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1695					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TATGTTGCAGGAATTCCAGGA	0.403000													36	41					0	0	1	0	0
CNGA2	1260	broad.mit.edu	37	X	150906989	150906989	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chrX:150906989C>T	ENST00000329903.4	+	1	67	c.34C>T	c.(34-36)Cca>Tca	p.P12S		NM_005140.1	NP_005131.1	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	12					response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(4)|endometrium(4)|large_intestine(5)|lung(34)|prostate(2)	49	Acute lymphoblastic leukemia(192;6.56e-05)					GAAGAGCTCCCCAGCCAATAA	0.512000													56	10					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85406065	85406065	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:85406065C>T	ENST00000258888.5	+	10	5102	c.4935C>T	c.(4933-4935)atC>atT	p.I1645I		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1645	Alpha-type protein kinase.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GCACGTGCATCATCAAGGTGT	0.582000													43	26					0	0	1	0	0
LINC00842	643650	broad.mit.edu	37	10	47133761	47133761	+	RNA	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:47133761C>T	ENST00000422732.2	-	0	435					NR_033957.1																						ACAGGGCTTTCCTAACTTCAC	0.458000													4	31					0	0	1	0	0
BMPR1B	658	broad.mit.edu	37	4	96046263	96046263	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:96046263C>T	ENST00000515059.1	+	8	859	c.576C>T	c.(574-576)ctC>ctT	p.L192L	BMPR1B_ENST00000394931.1_Silent_p.L192L|BMPR1B_ENST00000264568.4_Silent_p.L192L|BMPR1B_ENST00000440890.2_Silent_p.L222L	NM_001203.2	NP_001194.1	O00238	BMR1B_HUMAN	bone morphogenetic protein receptor, type IB	192	GS.				BMP signaling pathway|cartilage condensation|eye development|limb morphogenesis|ovarian cumulus expansion|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	receptor complex	ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta receptor activity			breast(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(8)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.51e-07)		GATCAGGCCTCCCTCTGCTGG	0.423000													7	12					0	0	1	0	0
OR4K13	390433	broad.mit.edu	37	14	20502075	20502075	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:20502075G>A	ENST00000315693.2	-	1	844	c.843C>T	c.(841-843)ctC>ctT	p.L281L		NM_001004714.1	NP_001004714.1	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K, member 13	281					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)	24	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		TAGGATTTAAGAGAGGTGTGA	0.333000													8	10					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135158747	135158747	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:135158747G>A	ENST00000372169.2	-	19	6632	c.6450C>T	c.(6448-6450)atC>atT	p.I2150I	SETX_ENST00000393220.1_Silent_p.I2150I|SETX_ENST00000224140.5_Silent_p.I2150I			Q7Z333	SETX_HUMAN	senataxin	2150					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TGCAGCAGATGATATGGGACT	0.453000													52	67					0	0	1	0	0
FAM117A	81558	broad.mit.edu	37	17	47799872	47799872	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:47799872G>A	ENST00000240364.2	-	3	530	c.451C>T	c.(451-453)Cac>Tac	p.H151Y	FAM117A_ENST00000514018.1_5'UTR|FAM117A_ENST00000513602.1_5'UTR	NM_030802.3	NP_110429.1	Q9C073	F117A_HUMAN	family with sequence similarity 117, member A	151										haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	17						TCTTTTCGGTGGTCTGTGCTG	0.582000													10	14					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36150095	36150095	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:36150095C>T	ENST00000303965.4	-	17	3421	c.2932G>A	c.(2932-2934)Gaa>Aaa	p.E978K		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	978	PH 3.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						AACACACGTTCGGAGGGTAAG	0.338000													9	7					0	0	1	0	0
PLS1	5357	broad.mit.edu	37	3	142396891	142396891	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:142396891C>T	ENST00000337777.3	+	6	728	c.515C>T	c.(514-516)tCt>tTt	p.S172F	PLS1_ENST00000457734.2_Missense_Mutation_p.S172F|PLS1_ENST00000497002.1_Missense_Mutation_p.S172F	NM_002670.2	NP_002661.2	Q14651	PLSI_HUMAN	plastin 1	172	Actin-binding 1.|CH 1.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	27						ATCAACTTATCTGAACCAGAT	0.284000													16	13					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57417794	57417794	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:57417794C>T	ENST00000543257.1	-	6	1003	c.437G>A	c.(436-438)gGt>gAt	p.G146D	C8B_ENST00000371237.4_Missense_Mutation_p.G198D|C8B_ENST00000535057.1_Missense_Mutation_p.G136D	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	198	LDL-receptor class A.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						GGAGCATCCACCTGCATAATA	0.478000													31	46					0	0	1	0	0
CHL1	10752	broad.mit.edu	37	3	407799	407799	+	Splice_Site	SNP	G	G	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:407799G>T	ENST00000256509.2	+	15	2393		c.e15+1		CHL1_ENST00000397491.2_Splice_Site|CHL1-AS1_ENST00000417612.1_RNA	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like						axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		AAGATGGCAGGTAGGTAAACT	0.373000													13	7					1.15088e-07	1.15638e-07	1	1	0
GRM1	2911	broad.mit.edu	37	6	146678764	146678764	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:146678764C>T	ENST00000392299.2	+	6	2006	c.1536C>T	c.(1534-1536)atC>atT	p.I512I	GRM1_ENST00000282753.1_Silent_p.I512I|GRM1_ENST00000507907.1_Silent_p.I512I|GRM1_ENST00000355289.4_Silent_p.I512I|GRM1_ENST00000492807.2_Silent_p.I512I|GRM1_ENST00000361719.2_Silent_p.I512I			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	512					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	ATTACAAAATCCAGATGAACA	0.443000													22	33					0	0	1	0	0
EGF	1950	broad.mit.edu	37	4	110932382	110932382	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:110932382G>A	ENST00000265171.5	+	24	3840	c.3395G>A	c.(3394-3396)aGg>aAg	p.R1132K	EGF_ENST00000509793.1_Missense_Mutation_p.R1090K|EGF_ENST00000503392.1_Missense_Mutation_p.R1091K	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	1132					angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	ACTTCATGGAGGCAGGAGCCC	0.448000													26	20					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41330595	41330595	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:41330595G>A	ENST00000551295.2	+	10	1115	c.998G>A	c.(997-999)tGg>tAg	p.W333*	CNTN1_ENST00000547849.1_Nonsense_Mutation_p.W333*|CNTN1_ENST00000347616.1_Nonsense_Mutation_p.W333*|CNTN1_ENST00000547702.1_Nonsense_Mutation_p.W333*|CNTN1_ENST00000348761.2_Nonsense_Mutation_p.W322*|CNTN1_ENST00000360099.3_Nonsense_Mutation_p.W333*	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	333	Ig-like C2-type 4.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TTCCCTGAGTGGGTAGAACAC	0.413000													6	9					0	0	1	0	0
CEP85	64793	broad.mit.edu	37	1	26594983	26594983	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:26594983C>T	ENST00000252992.4	+	8	1482	c.1351C>T	c.(1351-1353)Cgt>Tgt	p.R451C	CEP85_ENST00000451429.2_Missense_Mutation_p.R400C	NM_022778.2	NP_073615.2	Q6P2H3	CEP85_HUMAN	centrosomal protein 85kDa	451						centrosome|nucleolus|spindle pole				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(11)|skin(2)	25						GGTCAAAGGTCGTGATAAACA	0.473000													19	30					0	0	1	0	0
GPR116	221395	broad.mit.edu	37	6	46827084	46827084	+	Missense_Mutation	SNP	C	C	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:46827084C>A	ENST00000283296.7	-	17	2844	c.2556G>T	c.(2554-2556)caG>caT	p.Q852H	GPR116_ENST00000362015.4_Missense_Mutation_p.Q852H|GPR116_ENST00000545669.1_Missense_Mutation_p.Q281H|GPR116_ENST00000456426.2_Missense_Mutation_p.Q710H|GPR116_ENST00000265417.7_Missense_Mutation_p.Q852H	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	852					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			TGCTGCTCATCTGCACATTAG	0.458000													14	21					3.73148e-12	3.78556e-12	1	1	0
GRK5	2869	broad.mit.edu	37	10	121212313	121212313	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:121212313A>G	ENST00000392870.2	+	14	1864	c.1535A>G	c.(1534-1536)cAa>cGa	p.Q512R	GRK5_ENST00000369108.3_Missense_Mutation_p.Q407R|GRK5_ENST00000473264.1_3'UTR	NM_005308.2	NP_005299.1	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	512	AGC-kinase C-terminal.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			endometrium(2)|large_intestine(5)|lung(15)|skin(3)|stomach(1)|urinary_tract(1)	27		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		ATCCCATGGCAAAACGAGGTG	0.582000													17	16					0	0	1	0	0
FBXO16	157574	broad.mit.edu	37	8	28309810	28309810	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:28309810G>A	ENST00000380254.2	-	6	839	c.691C>T	c.(691-693)Cgt>Tgt	p.R231C	FBXO16_ENST00000517436.1_5'UTR|FBXO16_ENST00000346498.2_Missense_Mutation_p.R219C|RP11-181B11.2_ENST00000518819.1_RNA|FBXO16_ENST00000518734.1_Missense_Mutation_p.R219C|RP11-181B11.2_ENST00000523935.1_RNA	NM_001258211.1|NM_172366.3	NP_001245140.1|NP_758954.1	Q8IX29	FBX16_HUMAN	F-box protein 16	231										large_intestine(2)|ovary(1)	3		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.121)|Kidney(114;0.144)|Colorectal(74;0.249)		TAATTAAAACGAATGATATCT	0.423000													25	4					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52496381	52496381	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:52496381G>A	ENST00000216286.5	-	10	2284	c.2285C>T	c.(2284-2286)cCt>cTt	p.P762L	NID2_ENST00000541773.1_Missense_Mutation_p.P709L	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	762	EGF-like 2.					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					ATCATAGCAAGGATTCCCCGG	0.517000													15	26					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47955074	47955074	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:47955074C>T	ENST00000289672.2	-	8	1233	c.1183G>A	c.(1183-1185)Gac>Aac	p.D395N		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	395					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						ttactggggtctgagtcttcc	0.398000													23	25					0	0	1	0	0
ZNF329	79673	broad.mit.edu	37	19	58640040	58640040	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:58640040G>A	ENST00000598312.1	-	4	1064	c.831C>T	c.(829-831)caC>caT	p.H277H	ZNF329_ENST00000358067.4_Silent_p.H277H	NM_024620.3	NP_078896.3	Q86UD4	ZN329_HUMAN	zinc finger protein 329	277					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(10)|lung(5)|skin(3)|urinary_tract(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		GAATTCTCTGGTGCTGTGTCA	0.433000													62	51					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76450748	76450748	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:76450748G>A	ENST00000389840.5	-	64	10292	c.10168C>T	c.(10168-10170)Ctg>Ttg	p.L3390L	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Silent_p.L3399L					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TCTGTCAGCAGGCTCAAGGGA	0.587000													25	71					0	0	1	0	0
CEACAM1	634	broad.mit.edu	37	19	43026335	43026335	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:43026335G>A	ENST00000161559.6	-	3	578	c.444C>T	c.(442-444)tcC>tcT	p.S148S	LIPE-AS1_ENST00000594688.1_RNA|LIPE-AS1_ENST00000457234.2_RNA|CEACAM1_ENST00000599389.1_Silent_p.S148S|LIPE-AS1_ENST00000594624.2_RNA|CEACAM1_ENST00000358394.3_Silent_p.S148S|CEACAM1_ENST00000352591.5_Silent_p.S148S|CEACAM1_ENST00000351134.3_Intron|CEACAM1_ENST00000403444.3_Silent_p.S148S|CEACAM1_ENST00000308072.4_Silent_p.S108S|CEACAM1_ENST00000403461.1_Silent_p.S148S	NM_001712.4	NP_001703.2	P13688	CEAM1_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	148	Ig-like C2-type 1.				angiogenesis|cell migration|homophilic cell adhesion|integrin-mediated signaling pathway	extracellular region|integral to plasma membrane|membrane fraction				breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	17		Prostate(69;0.00682)		GBM - Glioblastoma multiforme(486;0.00148)	Arcitumomab(DB00113)	TGCTGGAGATGGAGGGCTTGG	0.488000													87	128					0	0	1	0	0
SERPINB2	5055	broad.mit.edu	37	18	61569054	61569054	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr18:61569054G>A	ENST00000457692.1	+	7	949	c.616G>A	c.(616-618)Gga>Aga	p.G206R	SERPINB2_ENST00000299502.4_Missense_Mutation_p.G206R|SERPINB2_ENST00000482254.1_3'UTR	NM_001143818.1	NP_001137290.1	P05120	PAI2_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 2	206					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|liver(1)|lung(12)|prostate(2)|skin(2)|stomach(1)	32		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	CTACTTCAAAGGAAAGTGGAA	0.383000													4	5					0	0	1	0	0
TMEM74B	55321	broad.mit.edu	37	20	1161566	1161566	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:1161566C>T	ENST00000381894.3	-	2	1368	c.697G>A	c.(697-699)Gat>Aat	p.D233N		NM_018354.1	NP_060824.1	Q9NUR3	CT046_HUMAN	transmembrane protein 74B	233						integral to membrane	protein binding										TGGCCCCCATCCCCATTGAGC	0.597000													24	36					0	0	1	0	0
ZNF608	57507	broad.mit.edu	37	5	123980230	123980230	+	Missense_Mutation	SNP	T	T	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:123980230T>A	ENST00000306315.5	-	5	4265	c.3830A>T	c.(3829-3831)aAa>aTa	p.K1277I	ZNF608_ENST00000504926.1_Missense_Mutation_p.K850I	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1277						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		ACCACTCTCTTTATTAGGAGT	0.423000													160	122					0	0	1	0	0
MYB	4602	broad.mit.edu	37	6	135517079	135517079	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:135517079C>T	ENST00000341911.5	+	9	1341	c.1142C>T	c.(1141-1143)aCc>aTc	p.T381I	MYB_ENST00000527615.1_Missense_Mutation_p.T381I|MYB-AS1_ENST00000455534.1_RNA|MYB_ENST00000367814.4_Missense_Mutation_p.T381I|MYB_ENST00000534121.1_Missense_Mutation_p.T381I|MYB_ENST00000528774.1_Missense_Mutation_p.T378I|MYB_ENST00000534044.1_Missense_Mutation_p.T381I|MYB_ENST00000316528.8_Missense_Mutation_p.T381I|MYB_ENST00000525369.1_Intron|MYB_ENST00000442647.2_Missense_Mutation_p.T378I|MYB_ENST00000531845.1_3'UTR|MYB_ENST00000533624.1_Missense_Mutation_p.T346I	NM_001130173.1|NM_001161656.1|NM_001161658.1	NP_001123645.1|NP_001155128.1|NP_001155130.1	P10242	MYB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog	381	Leucine-zipper.|Negative regulatory domain (By similarity).				blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	28	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		CACCAGGGCACCATTCTGGAT	0.473000			T	NFIB	adenoid cystic carcinoma								11	14					0	0	1	0	0
IL37	27178	broad.mit.edu	37	2	113670619	113670619	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:113670619G>A	ENST00000263326.3	+	1	72	c.30G>A	c.(28-30)gtG>gtA	p.V10V	IL37_ENST00000353225.3_Silent_p.V10V|IL37_ENST00000352179.3_Silent_p.V10V|IL37_ENST00000349806.3_Silent_p.V10V	NM_014439.3	NP_055254.2	Q9NZH6	IL37_HUMAN	interleukin 37	10					immune response	cytosol|extracellular space|nucleus	cytokine activity|interleukin-1 receptor antagonist activity|interleukin-1 receptor binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(1)|lung(7)|ovary(2)|skin(3)	19						ACTCAGGAGTGAAAATGGGCT	0.438000													32	36					0	0	1	0	0
CPA4	51200	broad.mit.edu	37	7	129962490	129962490	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:129962490G>A	ENST00000222482.4	+	11	1268	c.1240G>A	c.(1240-1242)Gag>Aag	p.E414K	CPA4_ENST00000493259.1_Missense_Mutation_p.E310K|CPA4_ENST00000445470.2_Missense_Mutation_p.E381K	NM_016352.3	NP_057436.2	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4	414					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Melanoma(18;0.0435)					GACCATCATGGAGCATGTGCG	0.532000													51	71					0	0	1	0	0
ACP1	52	broad.mit.edu	37	2	277292	277292	+	Silent	SNP	G	G	A	rs150164591		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:277292G>A	ENST00000272067.6	+	6	561	c.465G>A	c.(463-465)gaG>gaA	p.E155E	ACP1_ENST00000484464.1_3'UTR|ACP1_ENST00000272065.5_Silent_p.E155E	NM_007099.3	NP_009030.1	P24666	PPAC_HUMAN	acid phosphatase 1, soluble	155						cytoplasm|internal side of plasma membrane|nucleus|soluble fraction	acid phosphatase activity|identical protein binding|non-membrane spanning protein tyrosine phosphatase activity			endometrium(1)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	12	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00175)|Lung NSC(108;0.216)|all_epithelial(98;0.236)		all cancers(51;0.000391)|Epithelial(75;0.00281)|OV - Ovarian serous cystadenocarcinoma(76;0.00542)|GBM - Glioblastoma multiforme(21;0.127)		CGTTCTTGGAGAAGGCCCACT	0.542000													36	74					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195516895	195516895	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:195516895C>T	ENST00000463781.3	-	2	2015	c.1556G>A	c.(1555-1557)gGa>gAa	p.G519E	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.G519E	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	524					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGATGGATTTCCTGTGACAAG	0.532000													29	21					0	0	1	0	0
ZNF33A	7581	broad.mit.edu	37	10	38344720	38344720	+	Silent	SNP	C	C	T	rs138923692	by1000genomes	TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:38344720C>T	ENST00000374618.3	+	5	1846	c.1668C>T	c.(1666-1668)ccC>ccT	p.P556P	ZNF33A_ENST00000432900.2_Silent_p.P562P|ZNF33A_ENST00000307441.9_Silent_p.P555P|ZNF33A_ENST00000458705.2_Silent_p.P555P|ZNF33A_ENST00000469037.2_Intron	NM_001278170.1|NM_001278171.1|NM_001278173.1|NM_001278174.1|NM_001278175.1|NM_001278176.1|NM_001278177.1|NM_001278178.1|NM_001278179.1|NM_006954.1|NM_006974.2	NP_001265099.1|NP_001265100.1|NP_001265102.1|NP_001265103.1|NP_001265104.1|NP_001265105.1|NP_001265106.1|NP_001265107.1|NP_001265108.1|NP_008885.1|NP_008905.1	Q06730	ZN33A_HUMAN	zinc finger protein 33A	555						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P555P(1)		cervix(2)|endometrium(2)|large_intestine(8)|liver(2)|lung(27)|ovary(2)|prostate(1)|skin(2)	46						TTGCATGTCCCGAATGTGGGA	0.423000													20	35					0	0	1	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140710638	140710638	+	Missense_Mutation	SNP	C	C	G			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:140710638C>G	ENST00000517417.1	+	1	387	c.387C>G	c.(385-387)aaC>aaG	p.N129K	PCDHGA1_ENST00000378105.3_Missense_Mutation_p.N129K	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTAATGACAACACTCCCCAAT	0.403000													3	108					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57769394	57769394	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:57769394C>T	ENST00000371030.2	+	1	3320	c.3320C>T	c.(3319-3321)cCt>cTt	p.P1107L		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1107						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GGGGAGCCTCCTGGGAATGCC	0.652000													22	27					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53092774	53092774	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:53092774C>T	ENST00000276480.7	-	9	868	c.185G>A	c.(184-186)cGa>cAa	p.R62Q		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	62						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				GCTGTAGTGTCGGGGCTTCAT	0.517000													30	40					0	0	1	0	0
MTMR10	54893	broad.mit.edu	37	15	31234118	31234118	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:31234118T>C	ENST00000435680.1	-	16	1986	c.1889A>G	c.(1888-1890)tAt>tGt	p.Y630C	FAN1_ENST00000362065.4_3'UTR|MTMR10_ENST00000425768.1_3'UTR|MTMR10_ENST00000314404.8_Intron	NM_017762.2	NP_060232.2	Q9NXD2	MTMRA_HUMAN	myotubularin related protein 10	630	Myotubularin phosphatase.						phosphatase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|ovary(1)|upper_aerodigestive_tract(1)	9		all_lung(180;2.81e-11)		all cancers(64;7.26e-15)|Epithelial(43;7.2e-11)|GBM - Glioblastoma multiforme(186;0.000158)|BRCA - Breast invasive adenocarcinoma(123;0.00426)|Lung(196;0.174)		TTCTCTAAAATACTGCTCCGT	0.448000													84	112					0	0	1	0	0
TREM2	54209	broad.mit.edu	37	6	41129174	41129174	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:41129174G>A	ENST00000373113.3	-	2	311	c.218C>T	c.(217-219)tCc>tTc	p.S73F	TREM2_ENST00000338469.3_Missense_Mutation_p.S73F|TREM2_ENST00000373122.4_Missense_Mutation_p.S73F	NM_018965.2	NP_061838.1	Q9NZC2	TREM2_HUMAN	triggering receptor expressed on myeloid cells 2	73	Ig-like V-type.				axon guidance|humoral immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(2)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)	11	Ovarian(28;0.0418)|Colorectal(47;0.196)					CCTCAGGAAGGACAGCAGCCA	0.612000													139	45					0	0	1	0	0
MYBPC2	4606	broad.mit.edu	37	19	50939085	50939085	+	Silent	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:50939085C>T	ENST00000357701.5	+	3	213	c.162C>T	c.(160-162)ttC>ttT	p.F54F		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	54	Ig-like C2-type 1.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		CCGGCGTTTTCCTGAAGAAGC	0.662000													7	5					0	0	1	0	0
PDE4C	5143	broad.mit.edu	37	19	18322038	18322038	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:18322038C>T	ENST00000355502.3	-	19	2711	c.1840G>A	c.(1840-1842)Gac>Aac	p.D614N	PDE4C_ENST00000594617.2_Missense_Mutation_p.D614N|PDE4C_ENST00000262805.11_Missense_Mutation_p.D582N|PDE4C_ENST00000539010.1_Missense_Mutation_p.D383N|AC068499.10_ENST00000594805.2_RNA|PDE4C_ENST00000594465.2_Missense_Mutation_p.D614N|PDE4C_ENST00000447275.2_Missense_Mutation_p.D508N			Q08493	PDE4C_HUMAN	phosphodiesterase 4C, cAMP-specific	614					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33					Dyphylline(DB00651)	TGGACCAGGTCAGCCCAAGTC	0.577000													26	36					0	0	1	0	0
CORO2A	7464	broad.mit.edu	37	9	100897189	100897189	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:100897189C>T	ENST00000343933.5	-	4	624	c.367G>A	c.(367-369)Gcc>Acc	p.A123T	CORO2A_ENST00000375077.4_Missense_Mutation_p.A123T	NM_003389.3	NP_003380.3	Q92828	COR2A_HUMAN	coronin, actin binding protein, 2A	123					actin cytoskeleton organization|intracellular signal transduction	actin cytoskeleton|transcriptional repressor complex	actin filament binding			endometrium(2)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|skin(4)|urinary_tract(1)	26		Acute lymphoblastic leukemia(62;0.0559)				TTCCTGTAGGCCGTGAGGTTC	0.617000													25	35					0	0	1	0	0
UBQLNL	143630	broad.mit.edu	37	11	5537450	5537450	+	Silent	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:5537450G>A	ENST00000380184.1	-	1	485	c.222C>T	c.(220-222)ttC>ttT	p.F74F	HBG2_ENST00000380259.2_Intron	NM_145053.4	NP_659490.4	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	74	Ubiquitin-like.									endometrium(1)|kidney(3)|large_intestine(9)|lung(13)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		GGCAACCCATGAAGACCAGCA	0.498000													12	15					0	0	1	0	0
GRIN2D	2906	broad.mit.edu	37	19	48945520	48945520	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:48945520C>T	ENST00000263269.3	+	12	2642	c.2554C>T	c.(2554-2556)Ctc>Ttc	p.L852F		NM_000836.2	NP_000827.2	O15399	NMDE4_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	852						cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			autonomic_ganglia(1)|breast(6)|endometrium(2)|large_intestine(9)|lung(12)|ovary(5)|pancreas(1)|prostate(1)	37		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	CTTCTACATGCTCCTGGTGGC	0.627000													72	82					0	0	1	0	0
KIAA0226	9711	broad.mit.edu	37	3	197444889	197444889	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:197444889C>T	ENST00000389665.5	-	2	360	c.178G>A	c.(178-180)Gac>Aac	p.D60N	KIAA0226_ENST00000449205.1_Missense_Mutation_p.D60N|KIAA0226_ENST00000296343.5_Missense_Mutation_p.D60N|KIAA0226_ENST00000467303.1_Intron|KIAA0226_ENST00000273582.5_5'UTR			Q92622	RUBIC_HUMAN	KIAA0226	60	RUN.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding			NS(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		CTCTGCATGTCCCTGCAAAGC	0.507000													30	78					0	0	1	0	0
PRRC2A	7916	broad.mit.edu	37	6	31596971	31596971	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:31596971C>T	ENST00000376033.2	+	13	2050	c.1816C>T	c.(1816-1818)Cct>Tct	p.P606S	PRRC2A_ENST00000376007.4_Missense_Mutation_p.P606S	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	606	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						AGAAGAGGTTCCTCCTCCTAC	0.542000													380	72					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371804	240371804	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:240371804G>A	ENST00000319653.9	+	5	3922	c.3692G>A	c.(3691-3693)gGa>gAa	p.G1231E		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1231	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCTGGGACAGGAATCCCACCG	0.617000													8	71					0	0	1	0	0
AC016995.3	0	broad.mit.edu	37	2	38710017	38710019	+	RNA	DEL	AAT	AAT	-	rs2005502	by1000genomes	TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:38710017_38710019delAAT	ENST00000417039.1	-	0	696																											TTCTTtaaaaaataaataaataa	0.246													2	4	---	---	---	---					
LAMA2	3908	broad.mit.edu	37	6	129786364	129786365	+	Frame_Shift_Ins	INS	-	-	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:129786364_129786365insT	ENST00000421865.2	+	51	7279_7280	c.7230_7231insT	c.(7228-7233)tcttgtfs	p.C2411fs		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	2411	Laminin G-like 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GAATGGCTTCCGTTGTCAGCAA	0.386													5	3	---	---	---	---					
FIGNL1	63979	broad.mit.edu	37	7	50513275	50513275	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:50513275delA	ENST00000419119.1	-	2	3264	c.1711delT	c.(1711-1713)cafs	p.S571fs	FIGNL1_ENST00000356889.4_Frame_Shift_Del_p.S571fs|FIGNL1_ENST00000433017.1_Frame_Shift_Del_p.S571fs|FIGNL1_ENST00000395556.2_Frame_Shift_Del_p.S571fs			Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	571					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	29	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				TTCCTGGCTGAAGCTTCTGGG	0.443													41	31	---	---	---	---					
BHLHE22	27319	broad.mit.edu	37	8	65494021	65494023	+	In_Frame_Del	DEL	GCA	GCA	-	rs62519837		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:65494021_65494023delGCA	ENST00000321870.1	+	1	1208_1210	c.674_676delGCA	c.(673-678)ggc>g	p.GS225del	RP11-21C4.1_ENST00000517909.1_RNA	NM_152414.4	NP_689627.1	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix family, member e22	225	Gly-rich.|Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus		p.S234delS(1)|p.S226G(1)		NS(1)|central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	5						ggcagcggcggcagcagcagcag	0.709													2	4	---	---	---	---					
RP11-531A24.5	0	broad.mit.edu	37	8	73965670	73965672	+	RNA	DEL	CCT	CCT	-			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:73965670_73965672delCCT	ENST00000517664.1	+	0	1258_1260																											cctcacactccctcctcctcctc	0.429													2	4	---	---	---	---					
IGHMBP2	3508	broad.mit.edu	37	11	68704380	68704380	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:68704380delC	ENST00000255078.3	+	13	2543	c.2432delC	c.(2431-2433)acfs	p.T811fs		NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	811	Gln/Pro-rich.				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GTGCCCCCTACCCCTGCGCAG	0.697													39	11	---	---	---	---					
LOC100506125	100506125	broad.mit.edu	37	12	49183367	49183367	+	RNA	DEL	G	G	-	rs10711161		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:49183367delG	ENST00000549864.1	+	0	9																											ccctgccccagccccagcccc	0.657													6	4	---	---	---	---					
RP11-739G5.1	0	broad.mit.edu	37	15	94216840	94216841	+	RNA	DEL	TC	TC	-			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:94216840_94216841delTC	ENST00000554318.2	+	0	324																											tccttctccatctctctctcTG	0.441													2	4	---	---	---	---					
LOC101927009	101927009	broad.mit.edu	37	16	9488563	9488578	+	RNA	DEL	TCCCTTCCTTTCTCCC	TCCCTTCCTTTCTCCC	-	rs114802710	by1000genomes	TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:9488563_9488578delTCCCTTCCTTTCTCCC	ENST00000564305.1	+	0	193																											cctgcctccttcccttcctttctccctcccttcctc	0.597													4	3	---	---	---	---					
APOBR	55911	broad.mit.edu	37	16	28506895	28506897	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:28506895_28506897delAGG	ENST00000564831.1	+	2	566_568	c.533_535delAGG	c.(532-537)cag>c	p.QE178del	APOBR_ENST00000431282.1_In_Frame_Del_p.QE178del|APOBR_ENST00000328423.5_In_Frame_Del_p.QE178del	NM_018690.3	NP_061160.3	Q0VD83	APOBR_HUMAN	apolipoprotein B receptor	178	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|skin(2)|stomach(1)	29						AGCTGGGAACAGGAGGAGGAGGA	0.635													2	4	---	---	---	---					
ZNF646	9726	broad.mit.edu	37	16	31092264	31092264	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:31092264delA	ENST00000394979.2	+	1	5042	c.4619delA	c.(4618-4620)tcfs	p.Y1540fs	ZNF646_ENST00000300850.5_Frame_Shift_Del_p.Y1540fs			O15015	ZN646_HUMAN	zinc finger protein 646	1540					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(1)|lung(21)|ovary(1)|prostate(4)|skin(3)	49						GGCAAGACTTACTGCCAGTCA	0.537													47	65	---	---	---	---					
SCAF1	58506	broad.mit.edu	37	19	50155916	50155918	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:50155916_50155918delCCT	ENST00000360565.3	+	7	2394_2396	c.2270_2272delCCT	c.(2269-2274)gcc>g	p.AS757del		NM_021228.2	NP_067051.2	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	757	Ser-rich.				mRNA processing|RNA splicing	nucleus	RNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	20		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		TCGGGGGCCGCCTCCTCCTCCTC	0.690													3	6	---	---	---	---