Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HPCAL1	3241	broad.mit.edu	37	2	10559988	10559988	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr2:10559988C>T	ENST00000381765.3	+	4	631	c.105C>T	c.(103-105)ctC>ctT	p.L35L	HPCAL1_ENST00000307845.3_Silent_p.L35L	NM_134421.2	NP_602293.1	P37235	HPCL1_HUMAN	hippocalcin-like 1	35	EF-hand 1.						calcium ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	9	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.214)		AGGGCTTCCTCAAGGACTGCC	0.612000													12	30					0	0	0.001368	0	0
ZMAT1	84460	broad.mit.edu	37	X	101139487	101139487	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chrX:101139487G>A	ENST00000458570.1	-	9	1729	c.399C>T	c.(397-399)ttC>ttT	p.F133F	ZMAT1_ENST00000494068.1_5'UTR|ZMAT1_ENST00000540921.1_Silent_p.F304F|ZMAT1_ENST00000372782.3_Silent_p.F304F			A7MD47	A7MD47_HUMAN	zinc finger, matrin-type 1	133						nucleus	zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	22						GTTCATCTTGGAAAGAGTCAT	0.398000													56	41					0	0	0.003610	0	0
BAD	572	broad.mit.edu	37	11	64037607	64037607	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr11:64037607G>A	ENST00000544785.1	-	2	390	c.390C>T	c.(388-390)taC>taT	p.Y130Y	BAD_ENST00000309032.3_3'UTR|BAD_ENST00000394532.3_3'UTR			Q92934	BAD_HUMAN	BCL2-associated agonist of cell death	0					activation of pro-apoptotic gene products|ADP metabolic process|ATP metabolic process|cellular response to hypoxia|cellular response to mechanical stimulus|cellular response to nicotine|glucose homeostasis|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|pore complex assembly|positive regulation of epithelial cell proliferation|positive regulation of glucokinase activity|positive regulation of insulin secretion|positive regulation of mitochondrial membrane potential|positive regulation of type B pancreatic cell development|regulation of mitochondrial membrane permeability|type B pancreatic cell proliferation	cytosol|mitochondrial outer membrane	caspase activator activity|phospholipid binding|protein kinase binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(1)	4						CCTGAGGGAAGTACTTCCGCC	0.602000													15	11					0	0	0.004007	0	0
IGHV1OR21-1	390530	broad.mit.edu	37	21	10862643	10862643	+	RNA	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr21:10862643C>T	ENST00000559480.1	+	0	22																		p.L8L(1)		breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						TTGGAGGATCCTGTTTTTGGT	0.502000													33	369					0	0	0.002852	0	0
ANO4	121601	broad.mit.edu	37	12	101480466	101480466	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr12:101480466G>A	ENST00000392979.3	+	16	1821	c.1460G>A	c.(1459-1461)gGg>gAg	p.G487E	ANO4_ENST00000392977.3_Missense_Mutation_p.G522E|ANO4_ENST00000550015.1_Missense_Mutation_p.G42E|ANO4_ENST00000299222.9_Missense_Mutation_p.G42E	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	522						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						GCCGTGTTCGGGATCGTCATT	0.517000										HNSCC(74;0.22)			83	172					0	0	0.003610	0	0
DIDO1	11083	broad.mit.edu	37	20	61542877	61542877	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr20:61542877G>A	ENST00000266070.4	-	3	413	c.88C>T	c.(88-90)Cga>Tga	p.R30*	DIDO1_ENST00000395340.1_Nonsense_Mutation_p.R30*|DIDO1_ENST00000395335.2_Nonsense_Mutation_p.R30*|DIDO1_ENST00000370366.1_Nonsense_Mutation_p.R30*|DIDO1_ENST00000395343.1_Nonsense_Mutation_p.R30*|DIDO1_ENST00000266071.5_Nonsense_Mutation_p.R30*|DIDO1_ENST00000370368.1_Nonsense_Mutation_p.R30*|DIDO1_ENST00000370371.4_Nonsense_Mutation_p.R30*|DIDO1_ENST00000354665.4_Nonsense_Mutation_p.R30*	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	30					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GTGGTCCTTCGAAAACCCCAT	0.617000													11	7					0	0	0.001368	0	0
PRSS57	400668	broad.mit.edu	37	19	691996	691996	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr19:691996G>A	ENST00000329267.7	-	3	272	c.243C>T	c.(241-243)ctC>ctT	p.L81L		NM_214710.3	NP_999875.1	Q6UWY2	PRS57_HUMAN	protease, serine, 57	81	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|lung(5)	6						GGCCAGTGCGGAGGTCTCTGC	0.672000													13	5					0	0	0.002450	0	0
SECTM1	6398	broad.mit.edu	37	17	80282647	80282647	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr17:80282647C>T	ENST00000269389.3	-	3	564	c.214G>A	c.(214-216)Ggg>Agg	p.G72R	SECTM1_ENST00000580437.1_Missense_Mutation_p.G72R	NM_003004.2	NP_002995.1	Q8WVN6	SCTM1_HUMAN	secreted and transmembrane 1	72					immune response|mesoderm development|positive regulation of I-kappaB kinase/NF-kappaB cascade	extracellular space|Golgi apparatus|integral to membrane|plasma membrane	cytokine activity|signal transducer activity			endometrium(1)|large_intestine(2)|lung(1)	4	Breast(20;0.000675)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.249)		OV - Ovarian serous cystadenocarcinoma(97;0.00928)|BRCA - Breast invasive adenocarcinoma(99;0.0833)			CTCTCCTGCCCGTGGGCACGC	0.602000													9	10					0	0	0.006214	0	0
TRPM7	54822	broad.mit.edu	37	15	50931720	50931720	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr15:50931720G>A	ENST00000313478.7	-	6	842	c.561C>T	c.(559-561)gcC>gcT	p.A187A	TRPM7_ENST00000560955.1_Silent_p.A187A	NM_017672.4	NP_060142.3	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel, subfamily M, member 7	187					cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(17)|lung(13)|ovary(4)|pancreas(1)|skin(4)|stomach(3)	52				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		GTTCTTTGAGGGCATCTCCAA	0.388000													14	29					0	0	0.006122	0	0
MCM10	55388	broad.mit.edu	37	10	13224936	13224936	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr10:13224936A>G	ENST00000378694.1	+	7	1009	c.934A>G	c.(934-936)Aaa>Gaa	p.K312E	MCM10_ENST00000484800.2_Missense_Mutation_p.K313E|MCM10_ENST00000378714.3_Missense_Mutation_p.K312E			Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	313					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			central_nervous_system(1)|large_intestine(4)|ovary(2)|skin(1)|stomach(1)	9						GTTCCAGGGAAAAACCTTCAG	0.363000													17	7					0	0	0.004990	0	0
ZNFX1	57169	broad.mit.edu	37	20	47881379	47881379	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr20:47881379G>A	ENST00000396105.1	-	5	2271	c.2025C>T	c.(2023-2025)acC>acT	p.T675T	ZNFX1_ENST00000371754.4_Silent_p.T675T|ZNFX1_ENST00000371752.1_Silent_p.T675T	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	675							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GCACAATGCTGGTCTTCTGAC	0.527000													84	72					0	0	0.003610	0	0
MDGA1	266727	broad.mit.edu	37	6	37606313	37606313	+	Splice_Site	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr6:37606313C>T	ENST00000434837.2	-	15	3845	c.2667_splice	c.e15+1	p.Q889_splice	MDGA1_ENST00000505425.1_Splice_Site_p.Q889_splice|MDGA1_ENST00000297153.7_Splice_Site_p.Q893_splice	NM_153487.3	NP_705691.1	Q8NFP4	MDGA1_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 1	889	MAM.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	38						ACGGACTCACCTGGAAGGGCC	0.607000													12	48					0	0	0.003163	0	0
GUCY2F	2986	broad.mit.edu	37	X	108673535	108673535	+	Splice_Site	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chrX:108673535C>T	ENST00000218006.2	-	8	2083		c.e8+1			NM_001522.2	NP_001513.2	P51841	GUC2F_HUMAN	guanylate cyclase 2F, retinal						intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(6)|large_intestine(14)|lung(33)|prostate(3)|skin(1)	67						ATTTCTCATACCATTTCGAAC	0.378000													83	66					0	0	0.003610	0	0
CFH	3075	broad.mit.edu	37	1	196694339	196694339	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr1:196694339C>T	ENST00000367429.4	+	12	2025	c.1785C>T	c.(1783-1785)ttC>ttT	p.F595F		NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	595	Sushi 10.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						TGTTGAAATTCTCCTGCAAAC	0.393000													30	9					0	0	0.008361	0	0
OR1D4	653166	broad.mit.edu	37	17	3144090	3144090	+	RNA	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr17:3144090G>A	ENST00000531680.1	+	0	121					NR_033795.1				olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene)																		CACGGTGCTGGGAAATGTGCT	0.527000													23	54					0	0	0.004289	0	0
CHGB	1114	broad.mit.edu	37	20	5897512	5897512	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr20:5897512C>T	ENST00000378961.4	+	3	341	c.137C>T	c.(136-138)tCg>tTg	p.S46L	CHGB_ENST00000488832.1_3'UTR	NM_001819.2	NP_001810.2	P05060	SCG1_HUMAN	chromogranin B (secretogranin 1)	46						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						AATGCCTTGTCGAAGTCCAGC	0.557000													40	39					0	0	0.009718	0	0
DMD	1756	broad.mit.edu	37	X	31514964	31514964	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chrX:31514964G>A	ENST00000357033.4	-	57	8694	c.8488C>T	c.(8488-8490)Cgg>Tgg	p.R2830W	DMD_ENST00000343523.2_Missense_Mutation_p.R370W|DMD_ENST00000359836.1_Missense_Mutation_p.R370W|DMD_ENST00000474231.1_Missense_Mutation_p.R370W|DMD_ENST00000445312.1_5'UTR|DMD_ENST00000541735.1_Missense_Mutation_p.R370W|DMD_ENST00000378707.3_Missense_Mutation_p.R370W|DMD_ENST00000378677.2_Missense_Mutation_p.R2826W	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2830					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding	p.R2825W(1)|p.R2826W(1)|p.R370W(1)		NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GGTGCCTGCCGGCTTAATTCA	0.498000													19	15					0	0	0.001882	0	0
MUC17	140453	broad.mit.edu	37	7	100684854	100684854	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr7:100684854G>A	ENST00000306151.4	+	3	10221	c.10157G>A	c.(10156-10158)gGt>gAt	p.G3386D		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3386	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					ACTGCTGAAGGTACCAGCATA	0.507000													47	476					0	0	0.003610	0	0
SLC5A3	6526	broad.mit.edu	37	21	35468240	35468240	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr21:35468240T>C	ENST00000381151.3	+	2	1255	c.743T>C	c.(742-744)cTg>cCg	p.L248P	MRPS6_ENST00000399312.2_Intron	NM_006933.4	NP_008864.3	P53794	SC5A3_HUMAN	solute carrier family 5 (sodium/myo-inositol cotransporter), member 3	248						integral to plasma membrane	myo-inositol:sodium symporter activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	20						AAAGAAGCCCTGAAAATGCTG	0.463000													273	284					0	0	0.003610	0	0
PCDHA7	56141	broad.mit.edu	37	5	140214118	140214118	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr5:140214118G>A	ENST00000525929.1	+	1	150	c.150G>A	c.(148-150)caG>caA	p.Q50Q	PCDHA4_ENST00000530339.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000378125.3_Silent_p.Q50Q|PCDHA5_ENST00000529619.1_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCATCGCGCAGGACCTGGGGC	0.592000													71	22					0	0	0.003610	0	0
SAMD9	54809	broad.mit.edu	37	7	92731696	92731696	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr7:92731696G>A	ENST00000379958.2	-	3	3984	c.3715C>T	c.(3715-3717)Cca>Tca	p.P1239S		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1239						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			GGATCCCCTGGAATATCACTA	0.274000													22	119					0	0	0.002780	0	0
RBP3	5949	broad.mit.edu	37	10	48388676	48388676	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr10:48388676G>A	ENST00000224600.4	-	1	2315	c.2202C>T	c.(2200-2202)ttC>ttT	p.F734F		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	734	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	CCTCTGTCTTGAACAGGGCCT	0.637000													27	14					0	0	0.007291	0	0
KL	9365	broad.mit.edu	37	13	33638149	33638149	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr13:33638149C>T	ENST00000380099.3	+	5	2873	c.2865C>T	c.(2863-2865)ggC>ggT	p.G955G	KL_ENST00000487852.1_3'UTR	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	955					aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		GTTTCCCGGGCCCAGAAACTC	0.443000													33	54					0	0	0.002445	0	0
CHD1	1105	broad.mit.edu	37	5	98223809	98223809	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr5:98223809G>A	ENST00000284049.3	-	16	2628	c.2479C>T	c.(2479-2481)Cgt>Tgt	p.R827C		NM_001270.2	NP_001261.2	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	827	Helicase C-terminal.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	49		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	GGGAATTGACGATATTTCAAA	0.289000													9	27					0	0	0.000978	0	0
PLCL2	23228	broad.mit.edu	37	3	17052710	17052710	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr3:17052710C>T	ENST00000418129.2	+	2	1959	c.1494C>T	c.(1492-1494)atC>atT	p.I498I	PLCL2_ENST00000396755.2_Silent_p.I498I|PLCL2_ENST00000432376.1_Silent_p.I498I	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	624	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						TGGTCAGCATCTGCAAATCAG	0.433000													10	40					0	0	0.006214	0	0
KRT31	3881	broad.mit.edu	37	17	39551241	39551241	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr17:39551241G>A	ENST00000251645.2	-	6	1008	c.956C>T	c.(955-957)aCc>aTc	p.T319I		NM_002277.2	NP_002268.2	Q15323	K1H1_HUMAN	keratin 31	319	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	31		Breast(137;0.000496)				CTCCACGTTGGTGATCAGGCT	0.617000													24	38					0	0	0.002780	0	0
CD80	941	broad.mit.edu	37	3	119256003	119256003	+	Missense_Mutation	SNP	C	C	G			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr3:119256003C>G	ENST00000264246.3	-	4	1043	c.681G>C	c.(679-681)caG>caC	p.Q227H	CD80_ENST00000383668.3_Intron|CD80_ENST00000383669.3_Missense_Mutation_p.Q227H|CD80_ENST00000478182.1_Missense_Mutation_p.Q227H	NM_005191.3	NP_005182.1	P33681	CD80_HUMAN	CD80 molecule	227	Ig-like C2-type.				interspecies interaction between organisms|intracellular signal transduction|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of signal transduction|positive regulation of T-helper 1 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation	intracellular	coreceptor activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	12					Abatacept(DB01281)	AGTTGAAGGTCTGATTCACTC	0.368000													73	41					0	0	0.003610	0	0
MRC2	9902	broad.mit.edu	37	17	60757548	60757548	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr17:60757548C>T	ENST00000303375.5	+	15	2718	c.2316C>T	c.(2314-2316)ttC>ttT	p.F772F		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	772	C-type lectin 4.				endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						ACCACAATTTCGACCGGAGCC	0.647000													41	35					0	0	0.009718	0	0
ADAM18	8749	broad.mit.edu	37	8	39494794	39494794	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr8:39494794G>A	ENST00000265707.5	+	8	645	c.600G>A	c.(598-600)atG>atA	p.M200I	ADAM18_ENST00000379866.1_Intron|ADAM18_ENST00000541111.1_5'UTR	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	200	Peptidase M12B.				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			ATGATTATATGGGATCTGAAA	0.274000													15	24					0	0	0.003163	0	0
MTUS2	23281	broad.mit.edu	37	13	29599853	29599853	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr13:29599853C>T	ENST00000431530.3	+	1	1106	c.1048C>T	c.(1048-1050)Ctg>Ttg	p.L350L		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	340						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						GGAAGAGAATCTGTCAGCCTT	0.562000													20	32					0	0	0.008871	0	0
COL22A1	169044	broad.mit.edu	37	8	139839024	139839024	+	Splice_Site	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr8:139839024C>T	ENST00000303045.6	-	6	1292	c.845_splice	c.e6-1	p.E282_splice	COL22A1_ENST00000435777.1_Splice_Site_p.E282_splice	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	282	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GGAACACATCCCTGGAGAAAA	0.522000										HNSCC(7;0.00092)			12	24					0	0	0.001855	0	0
OR11H4	390442	broad.mit.edu	37	14	20711325	20711325	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr14:20711325G>A	ENST00000315409.2	+	1	428	c.375G>A	c.(373-375)ctG>ctA	p.L125L		NM_001004479.1	NP_001004479.1	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H, member 4	125					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	29	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		GTCTCTTTCTGGCAGTAATGG	0.463000													34	49					0	0	0.002096	0	0
LETMD1	25875	broad.mit.edu	37	12	51447632	51447632	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr12:51447632C>T	ENST00000418425.2	+	4	520	c.501C>T	c.(499-501)gtC>gtT	p.V167V	LETMD1_ENST00000262055.4_Silent_p.V154V|LETMD1_ENST00000550929.1_Silent_p.V98V|LETMD1_ENST00000547008.1_Intron|LETMD1_ENST00000548516.1_Intron|LETMD1_ENST00000380123.2_Intron|LETMD1_ENST00000552739.1_Intron	NM_001243689.1	NP_001230618.1	Q6P1Q0	LTMD1_HUMAN	LETM1 domain containing 1	154	LETM1.					integral to membrane|mitochondrial outer membrane	protein binding			central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(4)|skin(1)|urinary_tract(3)	16						ACTACCTGGTCTTCTTGCTAA	0.368000													41	123					0	0	0.003610	0	0
KRT78	196374	broad.mit.edu	37	12	53237949	53237949	+	Silent	SNP	C	C	T	rs140207612		TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr12:53237949C>T	ENST00000359499.4	-	6	656	c.645G>A	c.(643-645)acG>acA	p.T215T	KRT78_ENST00000304620.4_Silent_p.T325T			Q8N1N4	K2C78_HUMAN	keratin 78	325	Coil 1B.|Rod.					keratin filament	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18						TCTGGACTTTCGTTTCCTGCA	0.532000													51	104					0	0	0.003610	0	0
FADS6	283985	broad.mit.edu	37	17	72888728	72888728	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr17:72888728C>T	ENST00000310226.6	-	2	293	c.279G>A	c.(277-279)aaG>aaA	p.K93K		NM_178128.3	NP_835229.2	Q8N9I5	FADS6_HUMAN	fatty acid desaturase 6	99					fatty acid biosynthetic process	integral to membrane	oxidoreductase activity			endometrium(3)|kidney(1)|lung(4)	8	all_lung(278;0.172)|Lung NSC(278;0.207)					GGTGGCTGCCCTTGACAGTGA	0.592000													4	10					0	0	0.009096	0	0
ACAP1	9744	broad.mit.edu	37	17	7245641	7245641	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr17:7245641C>T	ENST00000158762.3	+	4	485	c.279C>T	c.(277-279)agC>agT	p.S93S	ACAP1_ENST00000573893.1_3'UTR	NM_014716.3	NP_055531.1	Q15027	ACAP1_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	93	BAR.|Required for formation of endosomal tubules when overexpressed with PIP5K1C.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			NS(1)|breast(5)|cervix(3)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|prostate(3)|skin(1)|urinary_tract(1)	33						AGCTGGACAGCCATGCGGTAA	0.567000													21	41					0	0	0.003330	0	0
OR6M1	390261	broad.mit.edu	37	11	123676126	123676126	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr11:123676126C>T	ENST00000309154.2	-	1	969	c.932G>A	c.(931-933)aGg>aAg	p.R311K		NM_001005325.1	NP_001005325.1	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M, member 1	311					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(2)|skin(5)|urinary_tract(1)	29		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		TCAAGTTTTCCTTTGTATCAA	0.378000													11	71					0	0	0.000978	0	0
PTGER3	5733	broad.mit.edu	37	1	71439984	71439984	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr1:71439984C>T	ENST00000306666.5	-	3	1375	c.1165G>A	c.(1165-1167)Gaa>Aaa	p.E389K	PTGER3_ENST00000370932.2_Intron|PTGER3_ENST00000370931.3_Missense_Mutation_p.E389K|PTGER3_ENST00000351052.5_Missense_Mutation_p.E418K|PTGER3_ENST00000414819.1_Missense_Mutation_p.E389K|PTGER3_ENST00000356595.4_Intron|PTGER3_ENST00000460330.1_Intron|PTGER3_ENST00000354608.5_Intron	NM_198719.1	NP_942012.1	P43115	PE2R3_HUMAN	prostaglandin E receptor 3 (subtype EP3)	389					cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity			endometrium(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25					Bimatoprost(DB00905)	tctcacctttccaaatggtcg	0.483000													5	43					0	0	0.003080	0	0
VPS4A	27183	broad.mit.edu	37	16	69354183	69354183	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr16:69354183C>T	ENST00000254950.11	+	7	916	c.760C>T	c.(760-762)Cag>Tag	p.Q254*	VPS4A_ENST00000569775.1_3'UTR|COG8_ENST00000564419.1_5'UTR|RP11-343C2.3_ENST00000570054.2_Nonsense_Mutation_p.Q278*	NM_013245.2	NP_037377.1	Q9UN37	VPS4A_HUMAN	vacuolar protein sorting 4 homolog A (S. cerevisiae)	254					cell cycle|cellular membrane organization|cytokinesis|endosome transport|protein transport	cytosol|late endosome membrane|midbody|perinuclear region of cytoplasm	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein domain specific binding			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(3)	7		Ovarian(137;0.101)				GTTCTTGGTCCAGATGCAGGG	0.572000													20	51					0	0	0.001882	0	0
OR56B1	387748	broad.mit.edu	37	11	5758272	5758272	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr11:5758272G>A	ENST00000317121.3	+	1	592	c.526G>A	c.(526-528)Gat>Aat	p.D176N	TRIM5_ENST00000380027.1_Intron	NM_001005180.2	NP_001005180.1	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B, member 1	176					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	13		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		AGCACAGCGTGATTATTGCTC	0.463000													13	53					0	0	0.002450	0	0
LZTFL1	54585	broad.mit.edu	37	3	45872564	45872564	+	Splice_Site	SNP	C	C	G			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr3:45872564C>G	ENST00000296135.6	-	6	697		c.e6+1		LZTFL1_ENST00000539217.1_Splice_Site|LZTFL1_ENST00000536047.1_Splice_Site|LZTFL1_ENST00000490463.1_Splice_Site	NM_001276378.1|NM_020347.2	NP_001263307.1|NP_065080.1	Q9NQ48	LZTL1_HUMAN	leucine zipper transcription factor-like 1											endometrium(1)|large_intestine(2)|lung(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	8				BRCA - Breast invasive adenocarcinoma(193;0.00867)|KIRC - Kidney renal clear cell carcinoma(197;0.0177)|Kidney(197;0.0208)		TTCTCAGTTACCTGTATTTCA	0.299000													12	19					0	0	0.001855	0	0
SCN8A	6334	broad.mit.edu	37	12	52159697	52159697	+	Silent	SNP	C	C	G			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr12:52159697C>G	ENST00000354534.5	+	16	2965	c.2787C>G	c.(2785-2787)gtC>gtG	p.V929V	SCN8A_ENST00000550891.1_Silent_p.V929V|SCN8A_ENST00000545061.1_Silent_p.V929V	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	929					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	TCCTCATTGTCTTTCGAGTGT	0.488000													99	188					0	0	0.003610	0	0
OR1D5	8386	broad.mit.edu	37	17	2966538	2966538	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr17:2966538G>A	ENST00000575751.1	-	1	363	c.364C>T	c.(364-366)Cgc>Tgc	p.R122C		NM_014566.1	NP_055381.1	P58170	OR1D5_HUMAN	olfactory receptor, family 1, subfamily D, member 5	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R122C(2)		kidney(1)|lung(10)	11						GCCACATAGCGATCATACGCC	0.567000													19	32					0	0	0.001882	0	0
KRTAP5-10	387273	broad.mit.edu	37	11	71277230	71277230	+	Missense_Mutation	SNP	G	G	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr11:71277230G>T	ENST00000398531.1	+	1	622	c.597G>T	c.(595-597)caG>caT	p.Q199H	KRTAP5-10_ENST00000376536.4_Intron	NM_001012710.1	NP_001012728.1	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	199						keratin filament				endometrium(2)|large_intestine(1)|lung(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	12						TGTGCTGCCAGTGTAAGATCT	0.547000													44	27					1.19451e-25	1.26162e-25	0.003610	1	0
OR4C46	119749	broad.mit.edu	37	11	51516171	51516171	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr11:51516171G>A	ENST00000328188.1	+	1	890	c.890G>A	c.(889-891)aGg>aAg	p.R297K		NM_001004703.1	NP_001004703.1	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C, member 46	297					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|large_intestine(5)|lung(31)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	48						AATGCCATCAGGAAATTGTGT	0.348000													7	23					0	0	0.003080	0	0
NGEF	25791	broad.mit.edu	37	2	233785073	233785073	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr2:233785073T>C	ENST00000264051.3	-	5	1027	c.749A>G	c.(748-750)aAc>aGc	p.N250S	NGEF_ENST00000409079.1_Missense_Mutation_p.N158S|NGEF_ENST00000373552.4_Missense_Mutation_p.N158S	NM_019850.2	NP_062824.2	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	250	Regulatory region; modulates activity toward RHOA, RAC1 and CDC42 (By similarity).				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(4)|endometrium(8)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|skin(4)	35		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		CTGCCAGAGGTTGAACCTTGA	0.617000													41	85					0	0	0.002522	0	0
AFP	174	broad.mit.edu	37	4	74313228	74313228	+	Missense_Mutation	SNP	A	A	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr4:74313228A>T	ENST00000395792.2	+	8	993	c.893A>T	c.(892-894)aAa>aTa	p.K298I	AFP_ENST00000226359.2_Missense_Mutation_p.K298I	NM_001134.1	NP_001125.1	P02771	FETA_HUMAN	alpha-fetoprotein	298	Albumin 2.				transport		metal ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(13)|ovary(1)|skin(1)|urinary_tract(1)	22	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CTGTCAAACAAAATAACAGAA	0.323000									Alpha-Fetoprotein, Hereditary Persistence of				17	24					0	0	0.007413	0	0
F8	2157	broad.mit.edu	37	X	154194287	154194287	+	Silent	SNP	G	G	A	rs149756842		TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chrX:154194287G>A	ENST00000360256.4	-	9	1601	c.1401C>T	c.(1399-1401)atC>atT	p.I467I	F8_ENST00000483822.1_5'UTR	NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	467	F5/8 type A 2.|Plastocyanin-like 3.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	AAGGTCCCAAGATTCCTGATT	0.408000													53	20					0	0	0.003610	0	0
OR52B6	340980	broad.mit.edu	37	11	5602813	5602813	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr11:5602813C>T	ENST00000345043.2	+	1	707	c.707C>T	c.(706-708)tCc>tTc	p.S236F	HBG2_ENST00000380259.2_Intron|AC015691.13_ENST00000394793.2_RNA	NM_001005162.2	NP_001005162.2	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B, member 6	236					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|lung(7)|ovary(1)|prostate(1)	12		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATTACTGTTTCCTACATCCAC	0.502000													41	150					0	0	0.009718	0	0
SPEG	10290	broad.mit.edu	37	2	220349085	220349085	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr2:220349085C>T	ENST00000312358.7	+	30	7032	c.6900C>T	c.(6898-6900)ccC>ccT	p.P2300P	AC053503.11_ENST00000429882.1_RNA|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	2300	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CCGGGGGTCCCCCGGTGCTAG	0.692000													12	14					0	0	0.001855	0	0
MUC17	140453	broad.mit.edu	37	7	100686896	100686896	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr7:100686896C>T	ENST00000306151.4	+	3	12263	c.12199C>T	c.(12199-12201)Cct>Tct	p.P4067S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	4067						extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					ACCTACATTTCCTCCTGCTCA	0.547000													114	47					0	0	0.003610	0	0
TRAV18	28665	broad.mit.edu	37	14	22471408	22471408	+	RNA	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr14:22471408G>A	ENST00000390446.3	+	0	64																											CTTTCGGTTTGGATATCTCTC	0.398000													15	29					0	0	0.003163	0	0
MYH8	4626	broad.mit.edu	37	17	10304076	10304076	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr17:10304076C>T	ENST00000403437.2	-	27	3460	c.3366G>A	c.(3364-3366)ggG>ggA	p.G1122G	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1122					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						CGATTTCTTCCCCCAGCTCCT	0.522000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				20	32					0	0	0.008871	0	0
XRN2	22803	broad.mit.edu	37	20	21335488	21335488	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr20:21335488C>T	ENST00000377191.3	+	21	2093	c.1998C>T	c.(1996-1998)taC>taT	p.Y666Y	XRN2_ENST00000539513.1_Silent_p.Y612Y|XRN2_ENST00000430571.2_Silent_p.Y590Y	NM_012255.3	NP_036387.2	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	666					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			endometrium(5)|kidney(6)|large_intestine(10)|lung(12)|ovary(1)|skin(5)	39						AAGAGGTATACCCAGACCTCA	0.408000													11	30					0	0	0.000978	0	0
SLC36A2	153201	broad.mit.edu	37	5	150696437	150696437	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr5:150696437C>T	ENST00000335244.4	-	10	1522	c.1393G>A	c.(1393-1395)Gag>Aag	p.E465K	SLC36A2_ENST00000450886.1_Missense_Mutation_p.E189K	NM_181776.2	NP_861441.2	Q495M3	S36A2_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 2	465					cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(14)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTGAGCAGCTCGTCCAGGGCC	0.572000													38	6					0	0	0.004289	0	0
MGA	23269	broad.mit.edu	37	15	42028814	42028814	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr15:42028814C>T	ENST00000219905.7	+	13	4533	c.4352C>T	c.(4351-4353)cCt>cTt	p.P1451L	MGA_ENST00000566586.1_Missense_Mutation_p.P1451L|MGA_ENST00000570161.1_Missense_Mutation_p.P1451L|MGA_ENST00000545763.1_Missense_Mutation_p.P1451L|MGA_ENST00000389936.4_Missense_Mutation_p.P1451L	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	1451						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		AAAGGTCTGCCTTTTTATGCA	0.473000													14	24					0	0	0.001855	0	0
GPR112	139378	broad.mit.edu	37	X	135426739	135426739	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chrX:135426739C>T	ENST00000394143.1	+	6	1165	c.874C>T	c.(874-876)Cca>Tca	p.P292S	GPR112_ENST00000370652.1_Missense_Mutation_p.P292S|GPR112_ENST00000287534.4_Missense_Mutation_p.P229S|GPR112_ENST00000412101.1_Missense_Mutation_p.P87S|GPR112_ENST00000394141.1_Missense_Mutation_p.P87S	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	292					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TACAACATCTCCACCTCTGGA	0.368000													36	51					0	0	0.005524	0	0
RLF	6018	broad.mit.edu	37	1	40702018	40702018	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr1:40702018G>A	ENST00000372771.4	+	8	1671	c.1644G>A	c.(1642-1644)caG>caA	p.Q548Q		NM_012421.3	NP_036553.2	Q13129	RLF_HUMAN	rearranged L-myc fusion	548					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(18)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(4)|urinary_tract(2)	68	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			AAAGATATCAGAGGTGGCTTC	0.348000													33	43					0	0	0.003271	0	0
ERV3-1	2086	broad.mit.edu	37	7	64452924	64452924	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr7:64452924G>A	ENST00000394323.2	-	2	981	c.481C>T	c.(481-483)Cca>Tca	p.P161S		NM_001007253.3	NP_001007254.2	Q14264	ENR1_HUMAN		161						virion				breast(1)|cervix(1)|endometrium(3)|large_intestine(3)|lung(8)	16						gttgttactggggaatcggtg	0.443000													45	100					0	0	0.008740	0	0
KIR2DL1	3802	broad.mit.edu	37	19	55290103	55290103	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr19:55290103G>A	ENST00000336077.6	+	5	744	c.704G>A	c.(703-705)aGc>aAc	p.S235N	KIR3DL1_ENST00000541392.1_Intron|KIR3DL1_ENST00000538269.1_Intron|KIR2DL4_ENST00000396284.2_Intron|CTB-61M7.1_ENST00000400864.3_RNA|KIR3DL1_ENST00000402254.2_Intron|KIR2DL3_ENST00000434419.2_Intron|KIR2DL1_ENST00000291633.7_Missense_Mutation_p.S235N	NM_014218.2	NP_055033.2	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	235					immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17				GBM - Glioblastoma multiforme(193;0.0192)		ACTGAACCAAGCTCCAAAACC	0.512000													72	44					0	0	0.003610	0	0
CD80	941	broad.mit.edu	37	3	119256110	119256110	+	Missense_Mutation	SNP	C	C	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr3:119256110C>A	ENST00000264246.3	-	4	936	c.574G>T	c.(574-576)Gat>Tat	p.D192Y	CD80_ENST00000383668.3_Intron|CD80_ENST00000383669.3_Missense_Mutation_p.D192Y|CD80_ENST00000478182.1_Missense_Mutation_p.D192Y	NM_005191.3	NP_005182.1	P33681	CD80_HUMAN	CD80 molecule	192	Ig-like C2-type.				interspecies interaction between organisms|intracellular signal transduction|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of signal transduction|positive regulation of T-helper 1 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation	intracellular	coreceptor activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	12					Abatacept(DB01281)	GTTTCAGGATCTTGGGAAACT	0.418000													76	45					3.82405e-32	4.06937e-32	0.003610	1	0
GFI1B	8328	broad.mit.edu	37	9	135865214	135865214	+	Missense_Mutation	SNP	C	C	G			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr9:135865214C>G	ENST00000339463.3	+	10	1553	c.734C>G	c.(733-735)aCg>aGg	p.T245R	GFI1B_ENST00000372124.1_Missense_Mutation_p.T199R|GFI1B_ENST00000372123.1_Missense_Mutation_p.T199R|GFI1B_ENST00000450530.1_Missense_Mutation_p.T245R|GFI1B_ENST00000534944.1_Missense_Mutation_p.T199R|GFI1B_ENST00000372122.1_Missense_Mutation_p.T245R			Q5VTD9	GFI1B_HUMAN	growth factor independent 1B transcription repressor	245	Interaction with ARIH2.|Mediates interaction with GATA1.				cell proliferation|chromatin modification|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	21				OV - Ovarian serous cystadenocarcinoma(145;9.04e-07)|Epithelial(140;1.17e-05)		CACTCAGACACGCGGCCCTAC	0.612000													23	10					0	0	0.001882	0	0
DENND5A	23258	broad.mit.edu	37	11	9199768	9199768	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr11:9199768G>A	ENST00000328194.3	-	8	2137	c.1817C>T	c.(1816-1818)tCc>tTc	p.S606F	DENND5A_ENST00000530044.1_Missense_Mutation_p.S606F|DENND5A_ENST00000526523.1_5'UTR	NM_001243254.1|NM_015213.3	NP_001230183.1|NP_056028.2	Q6IQ26	DEN5A_HUMAN	DENN/MADD domain containing 5A	606										breast(1)|endometrium(7)|kidney(2)|large_intestine(8)|liver(1)|lung(16)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GTCAACTCGGGAATCAAATAC	0.448000													31	142					0	0	0.002096	0	0
C17orf98	388381	broad.mit.edu	37	17	36991564	36991564	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr17:36991564A>G	ENST00000398575.4	-	3	408	c.343T>C	c.(343-345)Tac>Cac	p.Y115H		NM_001080465.2	NP_001073934.1	A8MV24	CQ098_HUMAN	chromosome 17 open reading frame 98	115										endometrium(5)|kidney(1)|large_intestine(1)|lung(3)|pancreas(1)|prostate(3)	14						TCAGCATTGTAGTGGTCATGC	0.577000													36	52					0	0	0.004289	0	0
GDF2	2658	broad.mit.edu	37	10	48414162	48414162	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr10:48414162C>T	ENST00000249598.1	-	2	865	c.706G>A	c.(706-708)Ggc>Agc	p.G236S		NM_016204.1	NP_057288.1	Q9UK05	GDF2_HUMAN	growth differentiation factor 2	236					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|endometrium(2)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	28						GTGTCGCAGCCCTTCCTGTGG	0.577000													21	16					0	0	0.010504	0	0
INADL	10207	broad.mit.edu	37	1	62350026	62350026	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr1:62350026C>T	ENST00000371158.2	+	22	3191	c.3077C>T	c.(3076-3078)tCc>tTc	p.S1026F	INADL_ENST00000316485.6_Missense_Mutation_p.S1026F	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	1026					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						CGAGTTATTTCCAAGGCCTCA	0.408000													62	77					0	0	0.003610	0	0
RP1	6101	broad.mit.edu	37	8	55540286	55540286	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr8:55540286C>T	ENST00000220676.1	+	4	3992	c.3844C>T	c.(3844-3846)Cct>Tct	p.P1282S		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1282					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CACTTTTTTTCCTAGTGATGG	0.408000													82	67					0	0	0.003610	0	0
PTK7	5754	broad.mit.edu	37	6	43098071	43098071	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr6:43098071C>T	ENST00000230419.4	+	4	795	c.574C>T	c.(574-576)Cct>Tct	p.P192S	PTK7_ENST00000349241.2_Missense_Mutation_p.P192S|PTK7_ENST00000481273.1_Missense_Mutation_p.P200S|PTK7_ENST00000471863.1_Missense_Mutation_p.P192S|PTK7_ENST00000345201.2_Missense_Mutation_p.P192S|PTK7_ENST00000352931.2_Missense_Mutation_p.P192S	NM_002821.4	NP_002812.2	Q13308	PTK7_HUMAN	protein tyrosine kinase 7	192	Ig-like C2-type 2.				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(12)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			GCCAGCTGGTCCTGAGCATAG	0.592000													28	16					0	0	0.006320	0	0
RTP2	344892	broad.mit.edu	37	3	187416342	187416342	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr3:187416342G>A	ENST00000358241.1	-	2	1050	c.622C>T	c.(622-624)Ctc>Ttc	p.L208F		NM_001004312.2	NP_001004312.2	Q5QGT7	RTP2_HUMAN	receptor (chemosensory) transporter protein 2	208					protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			large_intestine(3)|lung(14)|skin(1)	18	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0515)		AGCAGGCAGAGAGAGGCCCAG	0.582000													34	25					0	0	0.003755	0	0
PTPRB	5787	broad.mit.edu	37	12	70949899	70949899	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr12:70949899G>A	ENST00000334414.6	-	19	4788	c.4744C>T	c.(4744-4746)Cgg>Tgg	p.R1582W	PTPRB_ENST00000550857.1_Missense_Mutation_p.R1274W|PTPRB_ENST00000550358.1_Missense_Mutation_p.R1494W|PTPRB_ENST00000538708.1_Missense_Mutation_p.R1274W|PTPRB_ENST00000451516.2_Missense_Mutation_p.R1274W|PTPRB_ENST00000261266.5_Missense_Mutation_p.R1364W	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1364					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TTCTGAGGCCGGCAATGCAGG	0.453000													17	20					0	0	0.007413	0	0
RYR1	6261	broad.mit.edu	37	19	38973691	38973691	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr19:38973691C>T	ENST00000355481.4	+	32	4776	c.4645C>T	c.(4645-4647)Cct>Tct	p.P1549S	RYR1_ENST00000360985.3_Missense_Mutation_p.P1549S|RYR1_ENST00000359596.3_Missense_Mutation_p.P1549S	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1549	6 X approximate repeats.|B30.2/SPRY 3.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TAAGCTATTTCCTGCCGTCTT	0.582000													49	18					0	0	0.003610	0	0
RSF1	51773	broad.mit.edu	37	11	77409717	77409717	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr11:77409717G>A	ENST00000308488.6	-	7	2832	c.2530C>T	c.(2530-2532)Cga>Tga	p.R844*	RSF1_ENST00000480887.1_Nonsense_Mutation_p.R592*|RSF1_ENST00000360355.2_Nonsense_Mutation_p.R813*			Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	844					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding	p.R844*(1)		breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(9)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			CCAGTCCATCGAACTTTGCCT	0.368000													16	64					0	0	0.008871	0	0
PKD1L1	168507	broad.mit.edu	37	7	47880163	47880163	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr7:47880163C>T	ENST00000289672.2	-	35	5498	c.5448G>A	c.(5446-5448)gtG>gtA	p.V1816V		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1816	PLAT.				cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						AAACAATGTACACCTCAAAAC	0.507000													20	57					0	0	0.008871	0	0
PTPRB	5787	broad.mit.edu	37	12	70949900	70949900	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr12:70949900G>A	ENST00000334414.6	-	19	4787	c.4743C>T	c.(4741-4743)tgC>tgT	p.C1581C	PTPRB_ENST00000550857.1_Silent_p.C1273C|PTPRB_ENST00000550358.1_Silent_p.C1493C|PTPRB_ENST00000538708.1_Silent_p.C1273C|PTPRB_ENST00000451516.2_Silent_p.C1273C|PTPRB_ENST00000261266.5_Silent_p.C1363C	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1363					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TCTGAGGCCGGCAATGCAGGT	0.458000													17	19					0	0	0.007413	0	0
CEP250	11190	broad.mit.edu	37	20	34091962	34091962	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr20:34091962G>A	ENST00000397527.1	+	30	6485	c.5765G>A	c.(5764-5766)aGg>aAg	p.R1922K	CEP250_ENST00000342580.4_Missense_Mutation_p.R1866K	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	1922	Gln/Glu-rich.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GTGGAGACCAGGGCCCTGCAG	0.632000													10	27					0	0	0.000978	0	0
MXRA5	25878	broad.mit.edu	37	X	3240033	3240033	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chrX:3240033C>T	ENST00000217939.6	-	5	3847	c.3693G>A	c.(3691-3693)cgG>cgA	p.R1231R		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1231						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CGTGTTTTCTCCGTGGTGTTC	0.488000													47	29					0	0	0.003610	0	0
TNFRSF8	943	broad.mit.edu	37	1	12183362	12183362	+	Missense_Mutation	SNP	C	C	T	rs148865579		TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr1:12183362C>T	ENST00000263932.2	+	9	1190	c.968C>T	c.(967-969)aCc>aTc	p.T323I	TNFRSF8_ENST00000417814.2_Missense_Mutation_p.T212I	NM_001243.3	NP_001234.2	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily, member 8	323					cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		AAGGACACCACCTTTGAGGCG	0.612000													16	17					0	0	0.006122	0	0
KIAA1210	57481	broad.mit.edu	37	X	118222293	118222293	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chrX:118222293G>A	ENST00000402510.2	-	11	2899	c.2900C>T	c.(2899-2901)cCa>cTa	p.P967L		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	967										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						CATGCTCTTTGGAGATGAGGA	0.458000													23	35					0	0	0.002780	0	0
CUX2	23316	broad.mit.edu	37	12	111785777	111785777	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr12:111785777G>A	ENST00000261726.6	+	22	4263	c.4109G>A	c.(4108-4110)gGg>gAg	p.G1370E		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	1370	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						AGTGAGGCCGGGGAGCGACTT	0.607000													65	51					0	0	0.003610	0	0
TTN	7273	broad.mit.edu	37	2	179392293	179392293	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr2:179392293G>A	ENST00000589042.1	-	362	107784	c.107560C>T	c.(107560-107562)Caa>Taa	p.Q35854*	TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000342992.6_Nonsense_Mutation_p.Q33286*|TTN_ENST00000591111.1_Nonsense_Mutation_p.Q34213*|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000585625.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000587568.1_RNA|TTN_ENST00000342175.6_Nonsense_Mutation_p.Q26981*|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000604571.1_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN_ENST00000460472.2_Nonsense_Mutation_p.Q26789*|TTN_ENST00000359218.5_Nonsense_Mutation_p.Q26914*|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000589434.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	34213							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACATGCTTTGGGCAGACATG	0.453000													14	79					0	0	0.002450	0	0
PCYOX1L	78991	broad.mit.edu	37	5	148743682	148743682	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr5:148743682C>T	ENST00000514349.1	+	2	688	c.109C>T	c.(109-111)Ctg>Ttg	p.L37L	PCYOX1L_ENST00000274569.4_Silent_p.L127L			Q8NBM8	PCYXL_HUMAN	prenylcysteine oxidase 1 like	127					prenylcysteine catabolic process	extracellular region	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor			breast(2)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGACTGGTACCTGCTGAACCT	0.612000													39	15					0	0	0.004878	0	0
COL26A1	136227	broad.mit.edu	37	7	101183258	101183258	+	RNA	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr7:101183258G>A	ENST00000313669.7	+	0	724				COL26A1_ENST00000528707.1_RNA|COL26A1_ENST00000397927.3_RNA	NM_133457.2	NP_597714.2			collagen, type XXVI, alpha 1																		GACCTGGAATGAGGACTTCCT	0.662000													5	46					0	0	0.001168	0	0
POLR3B	55703	broad.mit.edu	37	12	106820975	106820975	+	Splice_Site	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr12:106820975C>T	ENST00000228347.4	+	13	1324	c.1101_splice	c.e13-1	p.L368_splice	POLR3B_ENST00000549195.1_3'UTR|POLR3B_ENST00000539066.1_Splice_Site_p.L310_splice	NM_018082.5	NP_060552.4	Q9NW08	RPC2_HUMAN	polymerase (RNA) III (DNA directed) polypeptide B	368					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding	p.L368F(4)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(22)|ovary(1)|prostate(3)|skin(3)|urinary_tract(2)	57						TTTTTTTTAGCTTTTATCTCT	0.274000													4	8					0	0	0.009096	0	0
PSRC1	84722	broad.mit.edu	37	1	109824520	109824520	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr1:109824520C>T	ENST00000438534.2	-	4	378	c.240G>A	c.(238-240)gaG>gaA	p.E80E	PSRC1_ENST00000369903.2_Silent_p.E80E|PSRC1_ENST00000409138.2_Silent_p.E80E|PSRC1_ENST00000369904.3_Silent_p.E80E|PSRC1_ENST00000369909.2_Silent_p.E80E|PSRC1_ENST00000369907.3_Silent_p.E80E|PSRC1_ENST00000409267.1_Silent_p.E80E	NM_001005290.3	NP_001005290.1	Q6PGN9	PSRC1_HUMAN	proline/serine-rich coiled-coil 1	80					cell division|microtubule bundle formation|mitotic metaphase plate congression|negative regulation of cell growth|positive regulation of microtubule polymerization|positive regulation of transcription, DNA-dependent|regulation of mitotic spindle organization	cytosol|midbody|spindle pole	microtubule binding			endometrium(1)|large_intestine(1)|lung(2)|prostate(2)|skin(1)	7		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0286)|Lung(183;0.0658)|COAD - Colon adenocarcinoma(174;0.112)|Epithelial(280;0.188)|all cancers(265;0.213)		GCCGGTTGGCCTCATCGAGGA	0.682000													54	261					0	0	0.003610	0	0
MGAM	8972	broad.mit.edu	37	7	141719032	141719032	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr7:141719032C>T	ENST00000475668.2	+	4	415	c.361C>T	c.(361-363)Ccc>Tcc	p.P121S	MGAM_ENST00000549489.2_Missense_Mutation_p.P121S			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	121	P-type 1.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TTGCTGGAATCCCCAGGGAGC	0.453000													22	158					0	0	0.001882	0	0
ZNF595	152687	broad.mit.edu	37	4	59415	59415	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr4:59415G>A	ENST00000509152.2	+	2	281	c.96G>A	c.(94-96)gtG>gtA	p.V32V	ZNF595_ENST00000339368.6_3'UTR|ZNF595_ENST00000526473.2_Silent_p.V32V					zinc finger protein 595											endometrium(5)|kidney(1)|large_intestine(1)|lung(11)|prostate(2)	20		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		ATAGAGATGTGATGTTGGAGA	0.428000													35	462					0	0	0.004878	0	0
C1orf173	127254	broad.mit.edu	37	1	75072544	75072544	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr1:75072544C>T	ENST00000326665.5	-	10	1448	c.1230G>A	c.(1228-1230)ccG>ccA	p.P410P	C1orf173_ENST00000420661.2_Silent_p.P213P|RP4-612J11.1_ENST00000416017.1_RNA	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	410								p.P410P(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TCCTAGATTTCGGCAAAGACG	0.413000													53	44					0	0	0.003610	0	0
PLB1	151056	broad.mit.edu	37	2	28804976	28804976	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr2:28804976G>A	ENST00000327757.5	+	24	1652	c.1608G>A	c.(1606-1608)aaG>aaA	p.K536K	PLB1_ENST00000329020.6_Silent_p.K224K|PLB1_ENST00000422425.2_Intron	NM_153021.4	NP_694566.4	Q6P1J6	PLB1_HUMAN	phospholipase B1	536	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					ACATTGGAAAGGCCCTGGACA	0.522000													36	47					0	0	0.006230	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175707	143175707	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr7:143175707C>T	ENST00000408916.1	+	1	742	c.742C>T	c.(742-744)Ctg>Ttg	p.L248L	EPHA1-AS1_ENST00000429289.1_RNA	NM_176883.2	NP_795364.2	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	248					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(2)|skin(1)	18	Melanoma(164;0.15)					TCTGTCCTTTCTGTCCCTGAT	0.512000													17	116					0	0	0.008871	0	0
NPAT	4863	broad.mit.edu	37	11	108059962	108059962	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr11:108059962G>A	ENST00000278612.8	-	6	532	c.427C>T	c.(427-429)Ctt>Ttt	p.L143F		NM_002519.2	NP_002510.2	Q14207	NPAT_HUMAN	nuclear protein, ataxia-telangiectasia locus	143	Interaction with MIZF.|Required for activation of histone gene transcription and interaction with MIZF.				positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(21)|ovary(2)|prostate(2)|skin(5)	46		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		TGTCCTGAAAGGTAAGGTAAA	0.468000													52	49					0	0	0.003610	0	0
TTN	7273	broad.mit.edu	37	2	179610452	179610452	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr2:179610452A>G	ENST00000360870.5	-	46	16897	c.16675T>C	c.(16675-16677)Ttc>Ctc	p.F5559L	TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000590773.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9028	Ig-like 36.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAACAGTGAACCTTCTTCCT	0.418000													23	62					0	0	0.002299	0	0
F8	2157	broad.mit.edu	37	X	154176015	154176015	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chrX:154176015G>A	ENST00000360256.4	-	13	2271	c.2071C>T	c.(2071-2073)Cca>Tca	p.P691S		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	691	F5/8 type A 2.|Plastocyanin-like 4.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CCTGAGAATGGGAATAGGGTG	0.403000													45	23					0	0	0.002522	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713650	70713650	+	RNA	SNP	T	T	G			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr14:70713650T>G	ENST00000530196.1	-	0	868					NR_003951.1																						ATACATGGAATCCACTATGTT	0.368000													24	44					0	0	0.003954	0	0
GABRG1	2565	broad.mit.edu	37	4	46043129	46043129	+	Missense_Mutation	SNP	C	C	T	rs75184362		TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr4:46043129C>T	ENST00000295452.4	-	9	1441	c.1274G>A	c.(1273-1275)gGa>gAa	p.G425E		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	425					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		CCTCCAAGATCCTGTTCTGCA	0.408000													51	60					0	0	0.003610	0	0
OR51A4	401666	broad.mit.edu	37	11	4968129	4968129	+	Silent	SNP	A	A	G			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr11:4968129A>G	ENST00000380373.2	-	1	227	c.202T>C	c.(202-204)Ttg>Ctg	p.L68L	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005329.1	NP_001005329.1	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A, member 4	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(15)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GACATAGCCAACATGGAAAGA	0.418000													43	40					0	0	0.009718	0	0
PIGV	55650	broad.mit.edu	37	1	27121193	27121193	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr1:27121193C>T	ENST00000374145.1	+	3	1350	c.668C>T	c.(667-669)tCt>tTt	p.S223F	PIGV_ENST00000449950.2_Intron|PIGV_ENST00000078527.4_Missense_Mutation_p.S223F	NM_001202554.1	NP_001189483.1	Q9NUD9	PIGV_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class V	223					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	glycolipid mannosyltransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)	14		all_cancers(24;3.93e-26)|all_epithelial(13;3.96e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.26e-54)|Epithelial(14;2.85e-53)|OV - Ovarian serous cystadenocarcinoma(117;1.91e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000504)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.0222)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)		GGCTTTTTCTCTTCTCTAACG	0.507000													48	43					0	0	0.002852	0	0
NEB	4703	broad.mit.edu	37	2	152500514	152500514	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr2:152500514C>T	ENST00000397345.3	-	57	7976	c.7774G>A	c.(7774-7776)Gac>Aac	p.D2592N	NEB_ENST00000409198.1_Missense_Mutation_p.D2592N|NEB_ENST00000172853.10_Missense_Mutation_p.D2592N|NEB_ENST00000604864.1_Missense_Mutation_p.D2592N|NEB_ENST00000603639.1_Missense_Mutation_p.D2592N|NEB_ENST00000427231.2_Missense_Mutation_p.D2592N	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	2592					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCTCAAAGTCCTTCTTGTAC	0.542000													132	352					0	0	0.003610	0	0
BICD2	23299	broad.mit.edu	37	9	95480126	95480126	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr9:95480126C>T	ENST00000356884.6	-	6	2278	c.2211G>A	c.(2209-2211)aaG>aaA	p.K737K	BICD2_ENST00000375512.3_Silent_p.K737K	NM_001003800.1	NP_001003800.1	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 (Drosophila)	737	Interacts with RAB6A (By similarity).				microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			cervix(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23						CTGCGTCCTCCTTGAGGGCCT	0.592000													41	12					0	0	0.006999	0	0
ZNF334	55713	broad.mit.edu	37	20	45130734	45130734	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr20:45130734A>G	ENST00000457685.2	-	6	2453	c.1130T>C	c.(1129-1131)tTt>tCt	p.F377S	ZNF334_ENST00000593880.1_Missense_Mutation_p.F438S|ZNF334_ENST00000347606.4_Missense_Mutation_p.F415S			Q9HCZ1	ZN334_HUMAN	zinc finger protein 334	415					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)				AGATTGACAAAAGAAGGTTTT	0.428000													36	68					0	0	0.003271	0	0
PASK	23178	broad.mit.edu	37	2	242077391	242077391	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr2:242077391G>A	ENST00000403638.3	-	6	944	c.853C>T	c.(853-855)Cct>Tct	p.P285S	PASK_ENST00000544142.1_Missense_Mutation_p.P99S|PASK_ENST00000539818.1_Missense_Mutation_p.P69S|PASK_ENST00000234040.4_Missense_Mutation_p.P285S|PASK_ENST00000405260.1_Missense_Mutation_p.P285S|PASK_ENST00000358649.4_Missense_Mutation_p.P285S	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	285					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		TGGCCAGAAGGAGGGAGCTGC	0.562000													28	37					0	0	0.006320	0	0
EIF2D	1939	broad.mit.edu	37	1	206770466	206770466	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr1:206770466C>T	ENST00000271764.2	-	12	1580	c.1372G>A	c.(1372-1374)Gac>Aac	p.D458N	EIF2D_ENST00000367114.3_Missense_Mutation_p.D334N|EIF2D_ENST00000472709.2_5'UTR	NM_006893.2	NP_008824.2	P41214	EIF2D_HUMAN	eukaryotic translation initiation factor 2D	458					intracellular protein transport	cytoplasm	protein binding|receptor activity|translation initiation factor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23						AGAAGACTGTCCCATGGAAGC	0.428000													15	8					0	0	0.007413	0	0
NXF3	56000	broad.mit.edu	37	X	102338427	102338427	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chrX:102338427G>A	ENST00000395065.3	-	5	540	c.439C>T	c.(439-441)Cac>Tac	p.H147Y	NXF3_ENST00000425644.1_5'UTR|NXF3_ENST00000425463.2_Missense_Mutation_p.H58Y	NM_022052.1	NP_071335.1	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	147	RRM.					cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26						TTTTCATAGTGAAACTATAGG	0.468000													25	18					0	0	0.002780	0	0
QPRT	23475	broad.mit.edu	37	16	29708339	29708339	+	Missense_Mutation	SNP	C	C	G			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr16:29708339C>G	ENST00000395384.4	+	3	733	c.572C>G	c.(571-573)gCg>gGg	p.A191G	QPRT_ENST00000219771.7_3'UTR|QPRT_ENST00000562473.1_Missense_Mutation_p.A43G	NM_014298.3	NP_055113.2	Q15274	NADC_HUMAN	quinolinate phosphoribosyltransferase	191					protein oligomerization|quinolinate catabolic process|water-soluble vitamin metabolic process	cytosol	nicotinate-nucleotide diphosphorylase (carboxylating) activity|protein homodimerization activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)	9					Niacin(DB00627)	GCCAGACAGGCGGCTGACTTC	0.687000													12	18					0	0	0.001855	0	0
CCDC66	285331	broad.mit.edu	37	3	56627732	56627732	+	Missense_Mutation	SNP	A	A	C			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr3:56627732A>C	ENST00000394672.3	+	9	1352	c.1282A>C	c.(1282-1284)Att>Ctt	p.I428L	CCDC66_ENST00000436465.2_Missense_Mutation_p.I428L|CCDC66_ENST00000326595.7_Missense_Mutation_p.I394L	NM_001012506.4|NM_001141947.1	NP_001012524.4|NP_001135419.1	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66	428										breast(1)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(2)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		AGCAAAACCTATTAAGGATGT	0.413000													55	21					0	0	0.003610	0	0
GUCY2C	2984	broad.mit.edu	37	12	14796584	14796584	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr12:14796584G>A	ENST00000261170.3	-	17	1990	c.1854C>T	c.(1852-1854)acC>acT	p.T618T		NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	618	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						CTACGCAGTTGGTAGATTTCA	0.388000													51	57					0	0	0.003610	0	0
CTAGE1	64693	broad.mit.edu	37	18	19997484	19997484	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr18:19997484C>T	ENST00000391403.2	-	1	394	c.291G>A	c.(289-291)ttG>ttA	p.L97L		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	97						integral to membrane				cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					AGGTTGCCTCCAAACTTTGTG	0.368000													73	113					0	0	0.003610	0	0
ENOX2	10495	broad.mit.edu	37	X	129813711	129813711	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chrX:129813711G>A	ENST00000338144.3	-	7	769	c.352C>T	c.(352-354)Cct>Tct	p.P118S	ENOX2_ENST00000370927.1_Missense_Mutation_p.P118S|ENOX2_ENST00000370935.1_Missense_Mutation_p.P89S|ENOX2_ENST00000394363.1_Missense_Mutation_p.P89S|ENOX2_ENST00000492263.1_5'UTR	NM_182314.1	NP_872114.1	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2	118	Pro-rich.				cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(3)	33						CGGGTTGCAGGAGGTGGGAGA	0.443000													25	40					0	0	0.005443	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				62	23					0	0	0.003610	0	0
PTBP3	9991	broad.mit.edu	37	9	114989800	114989800	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr9:114989800G>A	ENST00000334318.6	-	13	1534	c.1348C>T	c.(1348-1350)Ctg>Ttg	p.L450L	PTBP3_ENST00000374257.1_Silent_p.L419L|PTBP3_ENST00000458258.1_Silent_p.L453L|PTBP3_ENST00000343327.2_Silent_p.L352L|PTBP3_ENST00000374255.2_Silent_p.L447L	NM_001163790.2|NM_005156.6	NP_001157262.1|NP_005147.3	O95758	ROD1_HUMAN	polypyrimidine tract binding protein 3	447					anatomical structure morphogenesis|mRNA processing	nucleus	nucleotide binding|RNA binding										TCCTTAGTCAGACCTTGGTCT	0.453000													50	20					0	0	0.003610	0	0
TTC9	23508	broad.mit.edu	37	14	71134317	71134317	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr14:71134317G>A	ENST00000256367.2	+	2	786	c.443G>A	c.(442-444)cGa>cAa	p.R148Q		NM_015351.1	NP_056166.1	Q92623	TTC9A_HUMAN	tetratricopeptide repeat domain 9	148							binding			skin(1)	1				all cancers(60;0.00545)|BRCA - Breast invasive adenocarcinoma(234;0.00747)|OV - Ovarian serous cystadenocarcinoma(108;0.0538)		AACTATGAACGAGTCAAGGAA	0.522000													13	70					0	0	0.001855	0	0
ACSL5	51703	broad.mit.edu	37	10	114164518	114164518	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr10:114164518C>T	ENST00000393081.1	+	5	693	c.386C>T	c.(385-387)tCa>tTa	p.S129L	ACSL5_ENST00000479936.1_3'UTR|ACSL5_ENST00000433418.1_Missense_Mutation_p.S129L|ACSL5_ENST00000354273.4_Missense_Mutation_p.S129L|ACSL5_ENST00000354655.4_Missense_Mutation_p.S129L|ACSL5_ENST00000356116.1_Missense_Mutation_p.S185L	NM_203380.1	NP_976314.1	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	129					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|stomach(1)	21		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		GGTTATAAATCATCACCAGAC	0.413000													80	40					0	0	0.003610	0	0
MYOM2	9172	broad.mit.edu	37	8	2037919	2037919	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr8:2037919G>A	ENST00000262113.4	+	15	1874	c.1733G>A	c.(1732-1734)gGg>gAg	p.G578E	MYOM2_ENST00000523438.1_Missense_Mutation_p.G3E	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	578	Fibronectin type-III 2.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CTCATGGAAGGGAAGTCTTAT	0.577000													25	59					0	0	0.003330	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14796356	14796356	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr18:14796356G>A	ENST00000447268.2	+	17	1840	c.1840G>A	c.(1840-1842)Gaa>Aaa	p.E614K	ANKRD30B_ENST00000358984.4_Silent_p.R623R|ANKRD30B_ENST00000579292.1_Intron			Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	0										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						CCTGTGGAAGGAAAGTTTCTC	0.274000													4	3					0	0	0.009096	0	0
PLXNA4	91584	broad.mit.edu	37	7	131866146	131866146	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr7:131866146G>A	ENST00000359827.3	-	18	4448	c.3486C>T	c.(3484-3486)atC>atT	p.I1162I	PLXNA4_ENST00000321063.4_Silent_p.I1162I			Q9HCM2	PLXA4_HUMAN	plexin A4	1162	IPT/TIG 4.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CCACCTTTAGGATGATGGGCG	0.562000													166	62					0	0	0.003610	0	0
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													4	83					0	0	0.009096	0	0
RHBDF2	79651	broad.mit.edu	37	17	74473796	74473796	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr17:74473796G>A	ENST00000591885.1	-	7	1294	c.744C>T	c.(742-744)ttC>ttT	p.F248F	RHBDF2_ENST00000389760.4_Silent_p.F248F|RHBDF2_ENST00000313080.4_Silent_p.F277F			Q6PJF5	RHDF2_HUMAN	rhomboid 5 homolog 2 (Drosophila)	277					negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(4)|skin(1)	27						CCTCCTCCAGGAAGCTCGGGA	0.632000													32	42					0	0	0.002096	0	0
TTN	7273	broad.mit.edu	37	2	179398792	179398792	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr2:179398792C>T	ENST00000589042.1	-	358	102774	c.102550G>A	c.(102550-102552)Gaa>Aaa	p.E34184K	TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000591466.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E31616K|TTN_ENST00000591111.1_Missense_Mutation_p.E32543K|TTN-AS1_ENST00000588257.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E25311K|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000591867.1_RNA|TTN-AS1_ENST00000589842.1_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E25119K|TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E25244K|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000589434.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	32543	Ser-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.E25311K(1)|p.E31614K(1)|p.E25119K(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAGGTGATTTCGTATTTCTCA	0.403000													46	72					0	0	0.003610	0	0
GRID1	2894	broad.mit.edu	37	10	87487638	87487638	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr10:87487638C>T	ENST00000327946.7	-	10	1592	c.1507G>A	c.(1507-1509)Ggg>Agg	p.G503R	GRID1_ENST00000536331.1_Missense_Mutation_p.G74R	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	503						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	CCGATCATCCCGTTCCAGGAG	0.537000										Multiple Myeloma(13;0.14)			33	14					0	0	0.002836	0	0
TCF23	150921	broad.mit.edu	37	2	27375716	27375716	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr2:27375716C>T	ENST00000296096.5	+	3	756	c.626C>T	c.(625-627)cCa>cTa	p.P209L		NM_175769.2	NP_786951.1	Q7RTU1	TCF23_HUMAN	transcription factor 23	209					cell differentiation|muscle organ development|regulation of transcription, DNA-dependent	nucleus				large_intestine(2)|lung(11)|prostate(1)	14	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCACTCTCACCAGCTCTTGGT	0.537000													77	91					0	0	0.003610	0	0
EFTUD2	9343	broad.mit.edu	37	17	42964082	42964082	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr17:42964082G>A	ENST00000426333.2	-	3	439	c.142C>T	c.(142-144)Cat>Tat	p.H48Y	EFTUD2_ENST00000402521.3_Missense_Mutation_p.H13Y|EFTUD2_ENST00000592576.1_Missense_Mutation_p.H48Y|EFTUD2_ENST00000591382.1_Missense_Mutation_p.H48Y|EFTUD2_ENST00000589211.1_5'UTR	NM_001142605.1|NM_001258354.1|NM_004247.3	NP_001136077.1|NP_001245283.1|NP_004238.3	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain containing 2	48						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	32		Prostate(33;0.109)				tcatcgtcatgatctcctacg	0.512000													16	25					0	0	0.004007	0	0
IGLV9-49	28773	broad.mit.edu	37	22	22697959	22697959	+	RNA	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr22:22697959C>T	ENST00000427632.2	+	0	284																											GGATGGCATCCCTGATCGCTT	0.557000											OREG0026357	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	32					0	0	0.003080	0	0
SLC26A3	1811	broad.mit.edu	37	7	107427286	107427286	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr7:107427286C>T	ENST00000340010.5	-	8	1141	c.957G>A	c.(955-957)ggG>ggA	p.G319G	SLC26A3_ENST00000422236.2_Silent_p.G284G	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	319					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						GATTCATGTCCCCAACCACAG	0.468000													90	50					0	0	0.003610	0	0
IMPAD1	54928	broad.mit.edu	37	8	57878821	57878821	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr8:57878821G>A	ENST00000262644.4	-	4	995	c.737C>T	c.(736-738)tCa>tTa	p.S246L		NM_017813.4	NP_060283.3	Q9NX62	IMPA3_HUMAN	inositol monophosphatase domain containing 1	246						Golgi apparatus|integral to membrane	inositol-1(or 4)-monophosphatase activity|metal ion binding			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7		all_cancers(86;0.175)|all_lung(136;0.0321)|Lung NSC(129;0.0417)|all_epithelial(80;0.0448)				GACCATCCCTGAATGGGAACG	0.498000													41	53					0	0	0.007835	0	0
NUP160	23279	broad.mit.edu	37	11	47843330	47843330	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr11:47843330G>A	ENST00000378460.2	-	9	1269	c.1223C>T	c.(1222-1224)gCc>gTc	p.A408V	NUP160_ENST00000528501.1_5'UTR|NUP160_ENST00000528071.1_Missense_Mutation_p.A294V|NUP160_ENST00000530326.1_Missense_Mutation_p.A294V	NM_015231.1	NP_056046.1	Q12769	NU160_HUMAN	nucleoporin 160kDa	408					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|biliary_tract(2)|breast(7)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(6)|prostate(2)|skin(2)|urinary_tract(2)	53						ATGCCACAGGGCCCAGATATC	0.413000													13	68					0	0	0.003163	0	0
PPFIA1	8500	broad.mit.edu	37	11	70208222	70208222	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr11:70208222C>T	ENST00000253925.7	+	20	2819	c.2604C>T	c.(2602-2604)gcC>gcT	p.A868A	AP000487.6_ENST00000528607.1_RNA|PPFIA1_ENST00000389547.3_Silent_p.A868A	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	868					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			TGGAGGAAGCCCGGAGACAAG	0.483000													15	64					0	0	0.004007	0	0
CD80	941	broad.mit.edu	37	3	119256060	119256060	+	Missense_Mutation	SNP	C	C	G			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr3:119256060C>G	ENST00000264246.3	-	4	986	c.624G>C	c.(622-624)atG>atC	p.M208I	CD80_ENST00000383668.3_Intron|CD80_ENST00000383669.3_Missense_Mutation_p.M208I|CD80_ENST00000478182.1_Missense_Mutation_p.M208I	NM_005191.3	NP_005182.1	P33681	CD80_HUMAN	CD80 molecule	208	Ig-like C2-type.				interspecies interaction between organisms|intracellular signal transduction|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of signal transduction|positive regulation of T-helper 1 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation	intracellular	coreceptor activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	12					Abatacept(DB01281)	GGTTGGTTGTCATATTGAAAT	0.403000													80	44					0	0	0.003610	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110457223	110457223	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr8:110457223G>A	ENST00000378402.5	+	38	5229	c.5125G>A	c.(5125-5127)Gcc>Acc	p.A1709T		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1709	IPT/TIG 9.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GAATTATACGGCCATTGAATG	0.458000										HNSCC(38;0.096)			77	126					0	0	0.003610	0	0
OR6K3	391114	broad.mit.edu	37	1	158687446	158687446	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr1:158687446G>A	ENST00000368146.1	-	1	507	c.508C>T	c.(508-510)Ctt>Ttt	p.L170F	OR6K3_ENST00000368145.1_Missense_Mutation_p.L154F			Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K, member 3	170					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)	41	all_hematologic(112;0.0378)					AGCAGGATAAGGAAACCGAAG	0.512000													55	17					0	0	0.003610	0	0
MUC17	140453	broad.mit.edu	37	7	100684853	100684853	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr7:100684853G>A	ENST00000306151.4	+	3	10220	c.10156G>A	c.(10156-10158)Ggt>Agt	p.G3386S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3386	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AACTGCTGAAGGTACCAGCAT	0.512000													47	477					0	0	0.003610	0	0
FRG1B	284802	broad.mit.edu	37	20	29628261	29628261	+	Missense_Mutation	SNP	T	T	C	rs111331725	by1000genomes	TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr20:29628261T>C	ENST00000278882.3	+	6	643	c.263T>C	c.(262-264)tTt>tCt	p.F88S	FRG1B_ENST00000358464.4_Missense_Mutation_p.F88S|FRG1B_ENST00000439954.2_Missense_Mutation_p.F93S																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AATAGCTGCTTTATTAGATGC	0.363000													5	61					0	0	0.001984	0	0
KCNQ2	3785	broad.mit.edu	37	20	62065237	62065237	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr20:62065237G>A	ENST00000354587.3	-	8	1219	c.1043C>T	c.(1042-1044)gCc>gTc	p.A348V	KCNQ2_ENST00000344425.5_Missense_Mutation_p.A348V|KCNQ2_ENST00000357249.2_Missense_Mutation_p.A348V|KCNQ2_ENST00000359689.1_Missense_Mutation_p.A348V|KCNQ2_ENST00000344462.3_Missense_Mutation_p.A348V|KCNQ2_ENST00000370221.1_Missense_Mutation_p.A348V|KCNQ2_ENST00000482957.1_5'UTR|KCNQ2_ENST00000360480.3_Missense_Mutation_p.A348V|KCNQ2_ENST00000370224.1_Missense_Mutation_p.A348V|KCNQ2_ENST00000430658.1_Missense_Mutation_p.A348V|KCNQ2_ENST00000370226.1_Missense_Mutation_p.A348V|KCNQ2_ENST00000359125.2_Missense_Mutation_p.A348V|KCNQ2_ENST00000370222.3_Missense_Mutation_p.A348V			O43526	KCNQ2_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 2	348					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|liver(1)|lung(30)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	GAGGTTGGTGGCGTAGAATCT	0.692000													34	39					0	0	0.003271	0	0
CPEB3	22849	broad.mit.edu	37	10	93851681	93851681	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr10:93851681G>A	ENST00000412050.4	-	8	1639	c.1551C>T	c.(1549-1551)aaC>aaT	p.N517N	CPEB3_ENST00000265997.4_Silent_p.N531N	NM_001178137.1	NP_001171608.1	Q8NE35	CPEB3_HUMAN	cytoplasmic polyadenylation element binding protein 3	531	RRM 1.						nucleotide binding|RNA binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.0869)				TGTCACTTAGGTTCCATGGTC	0.433000													21	12					0	0	0.002780	0	0
CECR2	27443	broad.mit.edu	37	22	18028750	18028750	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr22:18028750C>T	ENST00000262608.8	+	16	3710	c.3710C>T	c.(3709-3711)tCt>tTt	p.S1237F	CECR2_ENST00000400585.2_Missense_Mutation_p.S1094F|CECR2_ENST00000400573.4_Missense_Mutation_p.S1236F	NM_031413.3	NP_113601.2	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	1278					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		GCCTTAACTTCTCCAACCCGT	0.547000													126	93					0	0	0.003610	0	0
DOK1	1796	broad.mit.edu	37	2	74782574	74782574	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr2:74782574C>T	ENST00000233668.5	+	2	1023	c.354C>T	c.(352-354)gcC>gcT	p.A118A	DOK1_ENST00000340004.6_Silent_p.A118A|DOK1_ENST00000480318.1_3'UTR|DOK1_ENST00000409429.1_5'UTR	NM_001381.3	NP_001372.1	Q99704	DOK1_HUMAN	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	118	PH.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol|perinuclear region of cytoplasm	insulin receptor binding			endometrium(3)|large_intestine(2)|liver(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16						GCCGAAACGCCTTTCCGGTGA	0.682000													14	12					0	0	0.001855	0	0
POLI	11201	broad.mit.edu	37	18	51820122	51820122	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr18:51820122C>T	ENST00000579534.1	+	10	1651	c.1508C>T	c.(1507-1509)cCa>cTa	p.P503L	POLI_ENST00000217800.5_Missense_Mutation_p.P377L|POLI_ENST00000406285.3_Missense_Mutation_p.P424L|POLI_ENST00000579434.1_Missense_Mutation_p.P400L|POLI_ENST00000582366.1_3'UTR	NM_007195.2	NP_009126.2	Q9UNA4	POLI_HUMAN	polymerase (DNA directed) iota	503					DNA repair|DNA replication	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(5)|ovary(3)|urinary_tract(1)	26				Colorectal(16;0.0234)|READ - Rectum adenocarcinoma(59;0.197)		AGGGAGTCTCCACTAGATACC	0.383000								DNA polymerases (catalytic subunits)					4	11					0	0	0.009096	0	0
COL4A5	1287	broad.mit.edu	37	X	107923941	107923941	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chrX:107923941G>A	ENST00000328300.6	+	45	4219	c.3975G>A	c.(3973-3975)atG>atA	p.M1325I	COL4A5_ENST00000361603.2_Missense_Mutation_p.M1319I	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	1319	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						TCAATGGAATGAAAGGAGATC	0.443000									Alport syndrome with Diffuse Leiomyomatosis				17	19					0	0	0.007413	0	0
AP3B2	8120	broad.mit.edu	37	15	83346062	83346062	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr15:83346062G>A	ENST00000261722.3	-	13	1659	c.1452C>T	c.(1450-1452)atC>atT	p.I484I	RP11-752G15.3_ENST00000560650.1_RNA|AP3B2_ENST00000535359.1_Silent_p.I484I|AP3B2_ENST00000535348.1_Silent_p.I452I	NM_004644.3	NP_004635.2	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2 subunit	484					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			breast(4)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(2)	41			BRCA - Breast invasive adenocarcinoma(143;0.229)			AGTGTTTGATGATCTCTCCAT	0.453000													3	21					0	0	0.004672	0	0
C17orf78	284099	broad.mit.edu	37	17	35743032	35743032	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr17:35743032G>A	ENST00000300618.4	+	4	527	c.477G>A	c.(475-477)ggG>ggA	p.G159G	ACACA_ENST00000353139.5_Intron|C17orf78_ENST00000586700.1_Intron|ACACA_ENST00000416895.1_Intron	NM_173625.3	NP_775896.3	Q8N4C9	CQ078_HUMAN	chromosome 17 open reading frame 78	159						integral to membrane				NS(1)|endometrium(1)|large_intestine(1)|lung(2)|stomach(1)	6		Breast(25;0.00295)|Ovarian(249;0.15)				TAACTCCTGGGAATAAAGAAG	0.383000													5	13					0	0	0.000602	0	0
WDFY3	23001	broad.mit.edu	37	4	85617207	85617207	+	Silent	SNP	T	T	C			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr4:85617207T>C	ENST00000322366.6	-	57	9173	c.8766A>G	c.(8764-8766)caA>caG	p.Q2922Q	WDFY3_ENST00000295888.4_Silent_p.Q2939Q			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	2939	BEACH.					cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		AGATATCCACTTGACCCTCAT	0.393000													14	58					0	0	0.001855	0	0
CNGB3	54714	broad.mit.edu	37	8	87683294	87683294	+	Missense_Mutation	SNP	A	A	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr8:87683294A>T	ENST00000320005.5	-	4	418	c.371T>A	c.(370-372)aTa>aAa	p.I124K		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	124					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						ATACTCATTTATAACAGGAGC	0.418000													95	204					0	0	0.003610	0	0
OPCML	4978	broad.mit.edu	37	11	132812919	132812919	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr11:132812919G>A	ENST00000331898.7	-	1	647	c.69C>T	c.(67-69)ttC>ttT	p.F23F	OPCML_ENST00000524381.1_Intron|OPCML_ENST00000541867.1_Silent_p.F23F|OPCML_ENST00000529038.1_Intron|OPCML_ENST00000374778.4_Intron	NM_002545.3	NP_002536.1	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion molecule-like	23					cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			endometrium(5)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|skin(2)|urinary_tract(8)	47	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		TGGGTACAAGGAACAGCAGCC	0.632000													15	41					0	0	0.004007	0	0
TENM3	55714	broad.mit.edu	37	4	183696119	183696119	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr4:183696119T>C	ENST00000511685.1	+	24	5240	c.5117T>C	c.(5116-5118)aTt>aCt	p.I1706T	TENM3_ENST00000406950.2_Missense_Mutation_p.I1706T					teneurin transmembrane protein 3																		TCCCTCAGAATTATCTACGCC	0.443000													10	15					0	0	0.008291	0	0
TENM3	55714	broad.mit.edu	37	4	183713931	183713931	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr4:183713931G>A	ENST00000511685.1	+	26	6229	c.6106G>A	c.(6106-6108)Gaa>Aaa	p.E2036K	TENM3_ENST00000406950.2_Missense_Mutation_p.E2036K					teneurin transmembrane protein 3																		TGTGATCAATGAAACGCCACT	0.393000													52	110					0	0	0.003610	0	0
GPR85	54329	broad.mit.edu	37	7	112724154	112724154	+	Missense_Mutation	SNP	A	A	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr7:112724154A>T	ENST00000501255.2	-	3	1246	c.623T>A	c.(622-624)tTc>tAc	p.F208Y	GPR85_ENST00000449591.1_Missense_Mutation_p.F208Y|GPR85_ENST00000424100.1_Missense_Mutation_p.F208Y|GPR85_ENST00000297146.2_Missense_Mutation_p.F208Y	NM_001146265.1|NM_001146266.1|NM_018970.6	NP_001139737.1|NP_001139738.1|NP_061843.3	P60893	GPR85_HUMAN	G protein-coupled receptor 85	208						integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	17						ATCGTGGACGAAAAATATCAG	0.502000													16	77					0	0	0.003163	0	0
MACROD2	140733	broad.mit.edu	37	20	15967391	15967391	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr20:15967391G>A	ENST00000217246.4	+	14	1400	c.1005G>A	c.(1003-1005)acG>acA	p.T335T	MACROD2_ENST00000402914.1_Silent_p.T100T|MACROD2_ENST00000407045.3_5'UTR|MACROD2_ENST00000310348.4_Silent_p.T335T|MACROD2_ENST00000378058.3_Silent_p.T100T	NM_080676.5	NP_542407.2	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2	335	Glu-rich.		T -> M (in dbSNP:rs41275442).							breast(2)|kidney(4)|large_intestine(5)|lung(8)|skin(1)	20		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				ATGATTCAACGAAGAATGAAA	0.338000													12	13					0	0	0.001368	0	0
SEMA3D	223117	broad.mit.edu	37	7	84647598	84647598	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr7:84647598G>A	ENST00000284136.6	-	13	1558	c.1515C>T	c.(1513-1515)atC>atT	p.I505I	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	505	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						TGTTCAAGATGATTGATGAGT	0.284000													6	42					0	0	0.004482	0	0
NEB	4703	broad.mit.edu	37	2	152521954	152521954	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr2:152521954G>A	ENST00000397345.3	-	42	5333	c.5131C>T	c.(5131-5133)Ctt>Ttt	p.L1711F	NEB_ENST00000409198.1_Missense_Mutation_p.L1711F|NEB_ENST00000172853.10_Missense_Mutation_p.L1711F|NEB_ENST00000604864.1_Missense_Mutation_p.L1711F|NEB_ENST00000603639.1_Missense_Mutation_p.L1711F|NEB_ENST00000427231.2_Missense_Mutation_p.L1711F	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	1711					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCTCACTAAGAATCTCTCCT	0.473000													10	24					0	0	0.008291	0	0
MMP15	4324	broad.mit.edu	37	16	58073843	58073843	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr16:58073843C>T	ENST00000219271.3	+	4	1290	c.505C>T	c.(505-507)Cgc>Tgc	p.R169C		NM_002428.2	NP_002419.1	P51511	MMP15_HUMAN	matrix metallopeptidase 15 (membrane-inserted)	169					protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	18						CAGGGCCTTCCGCGTGTGGGA	0.637000													31	18					0	0	0.002836	0	0
UBN2	254048	broad.mit.edu	37	7	138968702	138968702	+	Silent	SNP	T	T	C			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr7:138968702T>C	ENST00000288561.8	+	15	3051	c.2802T>C	c.(2800-2802)gcT>gcC	p.A934A	UBN2_ENST00000473989.2_Silent_p.A1017A	NM_173569.3	NP_775840.3	Q6ZU65	UBN2_HUMAN	ubinuclein 2	1017	Ser-rich.									NS(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	42						TAGCCAAGGCTATGGTGTCAC	0.527000													15	107					0	0	0.004007	0	0
ACAP1	9744	broad.mit.edu	37	17	7245642	7245642	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr17:7245642C>T	ENST00000158762.3	+	4	486	c.280C>T	c.(280-282)Cat>Tat	p.H94Y	ACAP1_ENST00000573893.1_3'UTR	NM_014716.3	NP_055531.1	Q15027	ACAP1_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	94	BAR.|Required for formation of endosomal tubules when overexpressed with PIP5K1C.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			NS(1)|breast(5)|cervix(3)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|prostate(3)|skin(1)|urinary_tract(1)	33						GCTGGACAGCCATGCGGTAAG	0.562000													21	39					0	0	0.003330	0	0
NPC1	4864	broad.mit.edu	37	18	21141326	21141326	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr18:21141326G>A	ENST00000269228.5	-	5	1183	c.629C>T	c.(628-630)tCa>tTa	p.S210L	NPC1_ENST00000540608.1_5'UTR	NM_000271.4	NP_000262.2	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1	210					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(10)|lung(13)|ovary(2)|stomach(1)	38	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					ATACCTACCTGAAAACACAGG	0.458000													55	91					0	0	0.003610	0	0
MYO15A	51168	broad.mit.edu	37	17	18058014	18058014	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr17:18058014C>T	ENST00000205890.5	+	45	8507	c.8169C>T	c.(8167-8169)tcC>tcT	p.S2723S	MYO15A_ENST00000585180.1_5'UTR|MYO15A_ENST00000418233.3_5'UTR	NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	2723	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					ACACGCTCTCCGAGGCCTGCC	0.597000													25	36					0	0	0.004656	0	0
MTUS1	57509	broad.mit.edu	37	8	17611259	17611259	+	Missense_Mutation	SNP	C	C	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr8:17611259C>A	ENST00000381869.3	-	2	2531	c.2058G>T	c.(2056-2058)atG>atT	p.M686I	MTUS1_ENST00000519263.1_Missense_Mutation_p.M686I|MTUS1_ENST00000381862.3_Missense_Mutation_p.M686I|MTUS1_ENST00000262102.6_Missense_Mutation_p.M686I	NM_001001925.2	NP_001001925.1	Q9ULD2	MTUS1_HUMAN	microtubule associated tumor suppressor 1	686						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(14)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	36				Colorectal(111;0.0778)		AAGTCTCATTCATAATCTCTT	0.343000													10	26					1.76689e-08	1.84542e-08	0.006214	1	0
MUC5B	727897	broad.mit.edu	37	11	1271266	1271266	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr11:1271266C>T	ENST00000447027.1	+	31	13223	c.13165C>T	c.(13165-13167)Ccg>Tcg	p.P4389S	MUC5B_ENST00000529681.1_Missense_Mutation_p.P4386S			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4386	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CTCCTCCACTCCGGGGACGAC	0.672000													21	64					0	0	0.001882	0	0
EPB41	2035	broad.mit.edu	37	1	29314233	29314233	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr1:29314233C>T	ENST00000343067.4	+	2	411	c.284C>T	c.(283-285)tCc>tTc	p.S95F	EPB41_ENST00000373798.1_Missense_Mutation_p.S95F|EPB41_ENST00000373800.3_5'UTR|EPB41_ENST00000373797.1_Missense_Mutation_p.S95F|EPB41_ENST00000356093.2_Missense_Mutation_p.S95F|EPB41_ENST00000349460.4_5'UTR|EPB41_ENST00000347529.3_Missense_Mutation_p.S95F|EPB41_ENST00000398863.2_Missense_Mutation_p.S95F	NM_001166005.1	NP_001159477.1	P11171	41_HUMAN	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	95					blood circulation|cortical actin cytoskeleton organization|positive regulation of protein binding	extrinsic to membrane|Golgi apparatus|nucleus|plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	1-phosphatidylinositol binding|actin binding|spectrin binding|structural constituent of cytoskeleton			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|urinary_tract(1)	14		Colorectal(325;3.46e-05)|Prostate(1639;0.000244)|Lung NSC(340;0.00328)|all_lung(284;0.00412)|Breast(348;0.00765)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.12e-07)|COAD - Colon adenocarcinoma(152;1.21e-05)|STAD - Stomach adenocarcinoma(196;0.00395)|KIRC - Kidney renal clear cell carcinoma(1967;0.0249)|BRCA - Breast invasive adenocarcinoma(304;0.0289)|READ - Rectum adenocarcinoma(331;0.0757)		TCTCAGGTGTCCGAGGAAGAA	0.423000													64	60					0	0	0.003610	0	0
TTN	7273	broad.mit.edu	37	2	179402438	179402438	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr2:179402438C>T	ENST00000589042.1	-	355	99720	c.99496G>A	c.(99496-99498)Gaa>Aaa	p.E33166K	TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E30598K|TTN_ENST00000591111.1_Missense_Mutation_p.E31525K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000415561.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E24293K|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E24101K|TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E24226K|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000589434.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	31525							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTCATCTTCCTGTTCCTCT	0.438000													15	44					0	0	0.002450	0	0
ANK1	286	broad.mit.edu	37	8	41577290	41577290	+	Missense_Mutation	SNP	G	G	C			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr8:41577290G>C	ENST00000396942.1	-	10	1079	c.996C>G	c.(994-996)gaC>gaG	p.D332E	ANK1_ENST00000352337.4_Missense_Mutation_p.D332E|ANK1_ENST00000347528.4_Missense_Mutation_p.D332E|ANK1_ENST00000396945.1_Missense_Mutation_p.D332E|ANK1_ENST00000379758.2_Missense_Mutation_p.D332E|ANK1_ENST00000289734.7_Missense_Mutation_p.D332E|ANK1_ENST00000265709.8_Missense_Mutation_p.D365E			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	332	89 kDa domain.		D -> H (in a breast cancer sample; somatic mutation).		axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GGGTGATGTCGTCTATCTCTG	0.587000													71	119					0	0	0.003610	0	0
SFXN1	94081	broad.mit.edu	37	5	174937146	174937146	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr5:174937146A>G	ENST00000321442.5	+	4	624	c.370A>G	c.(370-372)Aac>Gac	p.N124D	SFXN1_ENST00000502393.1_Missense_Mutation_p.N124D	NM_022754.5	NP_073591.2	Q9H9B4	SFXN1_HUMAN	sideroflexin 1	124					iron ion homeostasis	integral to membrane	cation transmembrane transporter activity|protein binding			endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|skin(3)	15	all_cancers(89;0.00922)|Renal(175;0.000269)|Lung NSC(126;0.00515)|all_lung(126;0.00873)	Medulloblastoma(196;0.0399)|all_neural(177;0.0663)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GCAGTGGATTAACCAGTCCTT	0.532000													10	6					0	0	0.000978	0	0
GIMAP8	155038	broad.mit.edu	37	7	150174613	150174613	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr7:150174613C>T	ENST00000307271.3	+	5	2317	c.1743C>T	c.(1741-1743)aaC>aaT	p.N581N		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	581						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		TCATGAAGAACTCAGATAACA	0.488000													22	143					0	0	0.001882	0	0
NAAA	27163	broad.mit.edu	37	4	76861192	76861192	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr4:76861192C>T	ENST00000286733.4	-	2	434	c.333G>A	c.(331-333)gcG>gcA	p.A111A	NAAA_ENST00000507956.1_Silent_p.A111A|NAAA_ENST00000507187.2_Silent_p.A111A|NAAA_ENST00000505594.1_Silent_p.A10A|NAAA_ENST00000399497.3_Silent_p.A111A	NM_014435.3	NP_055250.2	Q02083	NAAA_HUMAN	N-acylethanolamine acid amidase	111					lipid metabolic process	lysosome	hydrolase activity			endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	11						GAAGGCAGTCCGCCAGGCTGA	0.642000													29	43					0	0	0.007291	0	0
MTHFD1	4522	broad.mit.edu	37	14	64892780	64892780	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr14:64892780A>G	ENST00000555709.1	+	11	1384	c.997A>G	c.(997-999)Aag>Gag	p.K333E	MTHFD1_ENST00000216605.7_Missense_Mutation_p.K389E|MTHFD1_ENST00000555252.1_Missense_Mutation_p.K313E|MTHFD1_ENST00000545908.1_Missense_Mutation_p.K389E|CTD-2555O16.2_ENST00000556640.1_RNA	NM_005956.3	NP_005947.3	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	333	Formyltetrahydrofolate synthetase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase|methylenetetrahydrofolate dehydrogenase (NADP+) activity|protein binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	30				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	GCCCATTGGTAAGCTGGCTCG	0.403000													24	35					0	0	0.003330	0	0
KIAA0754	643314	broad.mit.edu	37	1	39879438	39879438	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr1:39879438G>A	ENST00000530275.1	+	1	3288	c.3093G>A	c.(3091-3093)gaG>gaA	p.E1031E	MACF1_ENST00000372915.3_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000545844.1_Intron|MACF1_ENST00000289893.4_Intron|MACF1_ENST00000567887.1_Intron|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000564288.1_Intron	NM_015038.1	NP_055853.1	O94854	K0754_HUMAN	KIAA0754	1031	Ala-rich.									central_nervous_system(1)|large_intestine(6)|skin(1)	8	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CCACCCCCGAGGAATCTGCCT	0.667000													5	28					0	0	0.001984	0	0
ATRN	8455	broad.mit.edu	37	20	3540071	3540071	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr20:3540071C>T	ENST00000262919.5	+	7	1212	c.1144C>T	c.(1144-1146)Cta>Tta	p.L382L	ATRN_ENST00000446916.2_Silent_p.L382L	NM_139321.2	NP_647537.1	O75882	ATRN_HUMAN	attractin	382					inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			breast(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	59						GTGGCTTCCACTAAACCGTTC	0.368000													26	52					0	0	0.005443	0	0
LINGO2	158038	broad.mit.edu	37	9	27950069	27950069	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr9:27950069G>A	ENST00000379992.2	-	6	1050	c.601C>T	c.(601-603)Cgc>Tgc	p.R201C	LINGO2_ENST00000308675.3_Missense_Mutation_p.R201C	NM_152570.2	NP_689783.1	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	201						integral to membrane				autonomic_ganglia(1)|breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	44	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		ATGAGGCTGCGGAGGTGGGAG	0.468000													31	9					0	0	0.004289	0	0
CHGB	1114	broad.mit.edu	37	20	5903556	5903556	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr20:5903556C>T	ENST00000378961.4	+	4	970	c.766C>T	c.(766-768)Caa>Taa	p.Q256*		NM_001819.2	NP_001810.2	P05060	SCG1_HUMAN	chromogranin B (secretogranin 1)	256						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						GTCTAAAGGCCAACCCCGAAG	0.587000													11	8					0	0	0.008291	0	0
RNF152	220441	broad.mit.edu	37	18	59483490	59483490	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr18:59483490G>A	ENST00000312828.3	-	2	1306	c.207C>T	c.(205-207)ctC>ctT	p.L69L		NM_173557.2	NP_775828.1	Q8N8N0	RN152_HUMAN	ring finger protein 152	69					apoptosis|protein K48-linked ubiquitination	integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)	17		Colorectal(73;0.186)				GGTCGTCCGGGAGCTGCGACA	0.627000													12	20					0	0	0.000978	0	0
DSCAM	1826	broad.mit.edu	37	21	42080415	42080415	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr21:42080415C>T	ENST00000400454.1	-	2	803	c.326G>A	c.(325-327)gGg>gAg	p.G109E		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	109	Ig-like C2-type 1.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TCTAATTTTCCCTGAAGGATT	0.448000													18	62					0	0	0.008871	0	0
SETD5	55209	broad.mit.edu	37	3	9517239	9517239	+	Missense_Mutation	SNP	C	C	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr3:9517239C>A	ENST00000402466.1	+	24	4267	c.3499C>A	c.(3499-3501)Cat>Aat	p.H1167N	SETD5_ENST00000402198.1_Missense_Mutation_p.H1265N|SETD5_ENST00000406341.1_Missense_Mutation_p.H1265N|SETD5_ENST00000407969.1_Missense_Mutation_p.H1284N|SETD5_ENST00000302463.6_Missense_Mutation_p.H1167N			Q9C0A6	SETD5_HUMAN	SET domain containing 5	1265	Ser-rich.									NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		CTTCAGAGGACATCCTACACA	0.507000													8	63					0.00307968	0.0031929	0.003080	1	0
FSTL5	56884	broad.mit.edu	37	4	162841804	162841804	+	Splice_Site	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr4:162841804C>T	ENST00000306100.5	-	4	597	c.160_splice	c.e4-1	p.G54_splice	FSTL5_ENST00000427802.2_Splice_Site_p.G53_splice|FSTL5_ENST00000536695.1_Splice_Site_p.G53_splice|FSTL5_ENST00000379164.4_Splice_Site_p.G53_splice	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	54						extracellular region	calcium ion binding	p.G54V(1)		central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		AATCATAAATCCTGAAGAATT	0.343000													12	22					0	0	0.001855	0	0
KRT35	3886	broad.mit.edu	37	17	39635641	39635641	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr17:39635641G>A	ENST00000246639.2	-	3	711	c.579C>T	c.(577-579)tcC>tcT	p.S193S	KRT35_ENST00000393989.1_Silent_p.S223S			Q92764	KRT35_HUMAN	keratin 35	223	Coil 1B.|Rod.				anatomical structure morphogenesis	intermediate filament	protein binding|structural molecule activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	29		Breast(137;0.000286)				CCTCCTTCAGGGACTCCACCT	0.607000													26	43					0	0	0.007291	0	0
SLC9A2	6549	broad.mit.edu	37	2	103274316	103274316	+	Missense_Mutation	SNP	G	G	A	rs61743555	byFrequency	TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr2:103274316G>A	ENST00000233969.2	+	2	725	c.583G>A	c.(583-585)Gaa>Aaa	p.E195K		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	195						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						CTGCCAGATCGAAGCATTCGG	0.478000													149	158					0	0	0.003610	0	0
PTPRG	5793	broad.mit.edu	37	3	62253112	62253112	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr3:62253112C>T	ENST00000474889.1	+	18	3061	c.2684C>T	c.(2683-2685)cCt>cTt	p.P895L	PTPRG-AS1_ENST00000479018.1_RNA|PTPRG-AS1_ENST00000495542.1_RNA|PTPRG-AS1_ENST00000462497.1_RNA|PTPRG_ENST00000295874.10_Missense_Mutation_p.P866L|PTPRG-AS1_ENST00000475371.1_RNA|PTPRG-AS1_ENST00000474795.1_RNA	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	895	Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		AAGTTAAGACCTTTACCAGGA	0.323000													12	132					0	0	0.002450	0	0
GRHL2	79977	broad.mit.edu	37	8	102570691	102570691	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr8:102570691G>A	ENST00000251808.3	+	4	667	c.329G>A	c.(328-330)gGa>gAa	p.G110E	GRHL2_ENST00000395927.1_Missense_Mutation_p.G94E	NM_024915.3	NP_079191.2	Q6ISB3	GRHL2_HUMAN	grainyhead-like 2 (Drosophila)	110						cytoplasm|nucleus	DNA binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			TTGAGTGGAGGAGAAAACCGA	0.463000													48	64					0	0	0.003610	0	0
SSH1	54434	broad.mit.edu	37	12	109181953	109181953	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr12:109181953G>A	ENST00000326495.5	-	15	3054	c.2961C>T	c.(2959-2961)ttC>ttT	p.F987F	SSH1_ENST00000360239.3_Silent_p.F675F	NM_018984.3	NP_061857.3	Q8WYL5	SSH1_HUMAN	slingshot protein phosphatase 1	987	Interaction with YWHAG.				actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CTTCCGTTGAGAAGGTGAGAC	0.602000													123	127					0	0	0.003610	0	0
UBE2I	7329	broad.mit.edu	37	16	1370213	1370213	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr16:1370213C>T	ENST00000355803.4	+	5	813	c.262C>T	c.(262-264)Cct>Tct	p.P88S	LA16c-358B7.3_ENST00000567829.1_RNA|UBE2I_ENST00000566587.1_Missense_Mutation_p.P88S|UBE2I_ENST00000325437.5_Missense_Mutation_p.P88S|UBE2I_ENST00000406620.1_Missense_Mutation_p.P88S|UBE2I_ENST00000397515.2_Missense_Mutation_p.P88S|UBE2I_ENST00000403747.2_Missense_Mutation_p.P88S|UBE2I_ENST00000402301.1_Missense_Mutation_p.P88S|LA16c-358B7.3_ENST00000568106.1_RNA|UBE2I_ENST00000397514.3_Missense_Mutation_p.P88S	NM_194260.2	NP_919236.1	P63279	UBC9_HUMAN	ubiquitin-conjugating enzyme E2I	88				VYPS -> GVPF (in Ref. 6; AAC50603).	cell division|chromosome segregation|interspecies interaction between organisms|mitosis|negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|protein sumoylation	cytoplasm|PML body|synaptonemal complex	ATP binding|enzyme binding|ubiquitin-protein ligase activity			breast(1)|large_intestine(2)|skin(1)|upper_aerodigestive_tract(1)	5		Hepatocellular(780;0.00369)				GAATGTGTACCCTTCGGGGAC	0.552000													14	47					0	0	0.002450	0	0
C7	730	broad.mit.edu	37	5	40945325	40945325	+	Missense_Mutation	SNP	A	A	C			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr5:40945325A>C	ENST00000313164.9	+	7	952	c.593A>C	c.(592-594)tAt>tCt	p.Y198S		NM_000587.2	NP_000578.2	P10643	CO7_HUMAN	complement component 7	198	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex							Ovarian(839;0.0112)				GATTTTAATTATGAATTTTAC	0.303000													7	7					0	0	0.001984	0	0
TBX18	9096	broad.mit.edu	37	6	85457732	85457732	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr6:85457732G>A	ENST00000369663.5	-	5	1182	c.845C>T	c.(844-846)tCt>tTt	p.S282F	TBX18_ENST00000606784.1_Missense_Mutation_p.S124F|TBX18_ENST00000606521.1_5'UTR	NM_001080508.1	NP_001073977.1	O95935	TBX18_HUMAN	T-box 18	282					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(9)|liver(1)|lung(31)|ovary(2)|pancreas(3)|prostate(6)|skin(3)	61		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		CTTGATGGGAGAAAGATCGTC	0.448000													6	20					0	0	0.001168	0	0
DHCR7	1717	broad.mit.edu	37	11	71152330	71152330	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr11:71152330G>A	ENST00000355527.3	-	6	845	c.569C>T	c.(568-570)gCc>gTc	p.A190V	DHCR7_ENST00000407721.2_Missense_Mutation_p.A190V	NM_001163817.1|NM_001360.2	NP_001157289.1|NP_001351.2	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	190					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(1)|skin(1)	19					NADH(DB00157)	GGTGGAGACGGCATAGCCAAG	0.557000									Smith-Lemli-Opitz syndrome				18	64					0	0	0.001882	0	0
NCOR2	9612	broad.mit.edu	37	12	124870393	124870393	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr12:124870393C>T	ENST00000356219.3	-	18	2072	c.1917G>A	c.(1915-1917)cgG>cgA	p.R639R	NCOR2_ENST00000404621.1_Silent_p.R638R|NCOR2_ENST00000429285.2_Silent_p.R638R|NCOR2_ENST00000405201.1_Silent_p.R639R|NCOR2_ENST00000404121.2_Silent_p.R209R|NCOR2_ENST00000397355.1_Silent_p.R639R	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	639	SANT 2.				cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		AGCCCACCATCCGGGCGATGG	0.592000													28	68					0	0	0.006320	0	0
C7	730	broad.mit.edu	37	5	40945307	40945307	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr5:40945307T>C	ENST00000313164.9	+	7	934	c.575T>C	c.(574-576)aTa>aCa	p.I192T		NM_000587.2	NP_000578.2	P10643	CO7_HUMAN	complement component 7	192	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex							Ovarian(839;0.0112)				TAGGTGAAAATAAATAATGAT	0.303000													4	2					0	0	0.009096	0	0
ANAPC1	64682	broad.mit.edu	37	2	112608394	112608394	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr2:112608394T>C	ENST00000341068.3	-	14	2381	c.1609A>G	c.(1609-1611)Act>Gct	p.T537A		NM_022662.3	NP_073153.1	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	537					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm		p.T537A(5)		NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(7)|lung(16)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	49						GGCTTTGGAGTACTAACGCCA	0.433000													4	96					0	0	0.009096	0	0
MAP4K3	8491	broad.mit.edu	37	2	39507459	39507459	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr2:39507459G>A	ENST00000263881.3	-	23	1992	c.1668C>T	c.(1666-1668)ccC>ccT	p.P556P	MAP4K3_ENST00000341681.5_Silent_p.P535P|MAP4K3_ENST00000536018.1_Silent_p.P109P|MAP4K3_ENST00000437545.1_Silent_p.P472P	NM_003618.3	NP_003609.2	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase kinase 3	556	CNH.				JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_hematologic(82;0.211)				GAATTTTCAAGGGACACCCAT	0.328000													27	26					0	0	0.002096	0	0
OR9A2	135924	broad.mit.edu	37	7	142724187	142724187	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr7:142724187G>A	ENST00000350513.2	-	1	95	c.33C>T	c.(31-33)ttC>ttT	p.F11F		NM_001001658.1	NP_001001658.1	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A, member 2	11					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(3)|endometrium(4)|large_intestine(1)|lung(14)|skin(3)	25	Melanoma(164;0.059)					CTAGAAGGTGGAATTCAGTGG	0.428000													46	30					0	0	0.003610	0	0
CDH16	1014	broad.mit.edu	37	16	66949202	66949202	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr16:66949202C>T	ENST00000299752.4	-	6	697	c.504G>A	c.(502-504)ctG>ctA	p.L168L	CDH16_ENST00000394055.3_Silent_p.L168L|CDH16_ENST00000565796.1_Silent_p.L168L|CDH16_ENST00000570262.1_Silent_p.L88L|CDH16_ENST00000568632.1_Intron	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	168	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GAGCCTGGCTCAGGATGTGGA	0.647000													15	48					0	0	0.003163	0	0
CLIP4	79745	broad.mit.edu	37	2	29386787	29386787	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr2:29386787A>G	ENST00000320081.5	+	13	1880	c.1625A>G	c.(1624-1626)tAt>tGt	p.Y542C	CLIP4_ENST00000401605.1_Missense_Mutation_p.Y542C|CLIP4_ENST00000404424.1_Missense_Mutation_p.Y542C|CLIP4_ENST00000401617.2_Missense_Mutation_p.Y435C	NM_024692.4	NP_078968.3	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family, member 4	542	CAP-Gly 2.									endometrium(4)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|prostate(1)|skin(1)	26	Acute lymphoblastic leukemia(172;0.155)					TCTCCAAGATATGGAATATTT	0.388000													22	48					0	0	0.001882	0	0
PADI6	353238	broad.mit.edu	37	1	17727845	17727845	+	RNA	SNP	T	T	G			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr1:17727845T>G	ENST00000434762.2	+	0	2047							Q6TGC4	PADI6_HUMAN	peptidyl arginine deiminase, type VI						peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(2)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	TGACTTTGACTGTTACCTGAC	0.542000													12	40					0	0	0.000978	0	0
NCOA6	23054	broad.mit.edu	37	20	33328797	33328797	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr20:33328797G>A	ENST00000374796.2	-	12	7833	c.5263C>T	c.(5263-5265)Cct>Tct	p.P1755S	NCOA6_ENST00000359003.2_Missense_Mutation_p.P1755S			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1755	EP300/CRSP3-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						GGATGAGAAGGGACAACTGGA	0.527000													31	48					0	0	0.008361	0	0
BAI3	577	broad.mit.edu	37	6	70071078	70071078	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr6:70071078G>A	ENST00000370598.1	+	29	4734	c.3913G>A	c.(3913-3915)Gaa>Aaa	p.E1305K	BAI3_ENST00000546190.1_Missense_Mutation_p.E269K|BAI3_ENST00000238918.8_Missense_Mutation_p.E511K	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1305					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				AAGAATGATGGAAAGTGACTA	0.388000													22	24					0	0	0.010504	0	0
CLDN23	137075	broad.mit.edu	37	8	8560416	8560416	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr8:8560416C>T	ENST00000519106.1	+	1	969	c.508C>T	c.(508-510)Ctg>Ttg	p.L170L		NM_194284.2	NP_919260.2	Q96B33	CLD23_HUMAN	claudin 23	170					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(2)	2		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.071)|READ - Rectum adenocarcinoma(644;0.238)		CAGCTGCCTCCTGCTGCTGGG	0.741000													9	5					0	0	0.006214	0	0
SAMD4A	23034	broad.mit.edu	37	14	55168907	55168907	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr14:55168907C>T	ENST00000251091.5	+	2	629	c.324C>T	c.(322-324)atC>atT	p.I108I	SAMD4A_ENST00000554335.1_Silent_p.I108I|SAMD4A_ENST00000357634.3_Silent_p.I107I|SAMD4A_ENST00000392067.3_Silent_p.I108I|SAMD4A_ENST00000555112.1_3'UTR	NM_001161576.2	NP_001155048.2	Q9UPU9	SMAG1_HUMAN	sterile alpha motif domain containing 4A	108				I -> T (in Ref. 3; AAH57838).	positive regulation of translation	cell junction|cytoplasm|dendrite|synapse|synaptosome	translation repressor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|prostate(1)|skin(1)	29						TGCCCAAAATCCTGGCTCACT	0.473000													21	38					0	0	0.002299	0	0
EPHB6	2051	broad.mit.edu	37	7	142568056	142568056	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr7:142568056G>A	ENST00000392957.2	+	18	3484	c.2697G>A	c.(2695-2697)caG>caA	p.Q899Q	EPHB6_ENST00000476059.1_3'UTR|EPHB6_ENST00000442129.1_Silent_p.Q899Q|EPHB6_ENST00000411471.2_Silent_p.Q622Q	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	899	Protein kinase.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					ACACTTGGCAGAAGGACCGTG	0.592000													52	268					0	0	0.003610	0	0
ZNF217	7764	broad.mit.edu	37	20	52198662	52198662	+	Missense_Mutation	SNP	C	C	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr20:52198662C>A	ENST00000371471.2	-	2	1129	c.704G>T	c.(703-705)cGc>cTc	p.R235L	ZNF217_ENST00000302342.3_Missense_Mutation_p.R235L			O75362	ZN217_HUMAN	zinc finger protein 217	235					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	50	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			GTGCACCTTGCGGTGCTCAAT	0.522000													84	92					1.86864e-30	1.98104e-30	0.003610	1	0
VPS13B	157680	broad.mit.edu	37	8	100115224	100115224	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr8:100115224C>T	ENST00000395996.1	+	5	567	c.456C>T	c.(454-456)aaC>aaT	p.N152N	VPS13B_ENST00000441350.2_Silent_p.N152N|VPS13B_ENST00000358544.2_Silent_p.N152N|VPS13B_ENST00000357162.2_Silent_p.N152N|VPS13B_ENST00000355155.1_Silent_p.N152N			Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	152					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			ATAATGTAAACATTGTGATAA	0.289000													11	70					0	0	0.001368	0	0
MED1	5469	broad.mit.edu	37	17	37563941	37563941	+	Silent	SNP	A	A	G			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr17:37563941A>G	ENST00000300651.6	-	17	4756	c.4533T>C	c.(4531-4533)gaT>gaC	p.D1511D	MED1_ENST00000394287.3_Intron	NM_004774.3	NP_004765.2	Q15648	MED1_HUMAN	mediator complex subunit 1	1511	Lys-rich.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			NS(1)|breast(2)|cervix(3)|kidney(3)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(7)|urinary_tract(1)	59		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		ctcggtccctatctttgtctt	0.443000										HNSCC(31;0.082)			15	33					0	0	0.002450	0	0
PDZD2	23037	broad.mit.edu	37	5	31983492	31983492	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr5:31983492C>T	ENST00000438447.1	+	3	1096	c.708C>T	c.(706-708)ggC>ggT	p.G236G	PDZD2_ENST00000282493.3_Silent_p.G236G			O15018	PDZD2_HUMAN	PDZ domain containing 2	236					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						AATCCAAGGGCAGCGCTGGCT	0.572000													23	58					0	0	0.003330	0	0
LAIR1	3903	broad.mit.edu	37	19	54866989	54866989	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr19:54866989T>C	ENST00000391743.3	-	9	978	c.698A>G	c.(697-699)tAt>tGt	p.Y233C	LAIR1_ENST00000474878.1_Missense_Mutation_p.Y233C|LAIR1_ENST00000348231.4_Missense_Mutation_p.Y234C|LAIR1_ENST00000313038.6_Missense_Mutation_p.Y244C|LAIR1_ENST00000391742.2_Missense_Mutation_p.Y251C|LAIR1_ENST00000434277.2_Missense_Mutation_p.Y250C			Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like receptor 1	251						integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(4)|prostate(1)|stomach(3)	26	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		CAGCTGAGCATACGTCACCTC	0.652000													42	10					0	0	0.009718	0	0
TUBGCP2	10844	broad.mit.edu	37	10	135095737	135095737	+	Missense_Mutation	SNP	A	A	C			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr10:135095737A>C	ENST00000368563.2	-	16	2755	c.2399T>G	c.(2398-2400)cTc>cGc	p.L800R	TUBGCP2_ENST00000368562.1_Missense_Mutation_p.L393R|TUBGCP2_ENST00000543663.1_Missense_Mutation_p.L828R|TUBGCP2_ENST00000417178.2_Missense_Mutation_p.L670R|TUBGCP2_ENST00000252936.3_Missense_Mutation_p.L800R	NM_001256617.1|NM_006659.3	NP_001243546.1|NP_006650.1	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	800					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding			breast(2)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	35		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		CTTCCTGGCGAGCTCCTTCCG	0.682000													8	8					0	0	0.003080	0	0
SDK2	54549	broad.mit.edu	37	17	71415334	71415334	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr17:71415334C>T	ENST00000392650.3	-	16	2157	c.2157G>A	c.(2155-2157)caG>caA	p.Q719Q	SDK2_ENST00000388726.3_Silent_p.Q719Q	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	719	Fibronectin type-III 2.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						GAATTCCATTCTGGTGGCTCT	0.617000													17	6					0	0	0.006122	0	0
MGAT5B	146664	broad.mit.edu	37	17	74944062	74944062	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr17:74944062T>C	ENST00000569840.2	+	17	2648	c.2074T>C	c.(2074-2076)Tgg>Cgg	p.W692R	MGAT5B_ENST00000428789.2_Missense_Mutation_p.W701R|MGAT5B_ENST00000301618.4_Missense_Mutation_p.W690R	NM_001199172.1	NP_001186101.1	Q3V5L5	MGT5B_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B	692						Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(15)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CCTGCGGGCCTGGCTGGCCGT	0.697000													7	14					0	0	0.001984	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18809378	18809378	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr1:18809378G>A	ENST00000400664.1	+	1	1955	c.1903G>A	c.(1903-1905)Gaa>Aaa	p.E635K		NM_152375.2	NP_689588.2	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	635						integral to membrane				endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GCGTGCCAAGGAAATCTTCGT	0.711000													10	17					0	0	0.008291	0	0
COMMD4	54939	broad.mit.edu	37	15	75632106	75632106	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr15:75632106C>T	ENST00000267935.8	+	7	645	c.446C>T	c.(445-447)tCc>tTc	p.S149F	COMMD4_ENST00000562789.1_Intron|COMMD4_ENST00000567195.1_Intron|COMMD4_ENST00000564815.1_Missense_Mutation_p.S127F|COMMD4_ENST00000338995.6_Intron	NM_017828.3	NP_060298.2	Q9H0A8	COMD4_HUMAN	COMM domain containing 4	149	COMM.					cytoplasm	protein binding			breast(3)|endometrium(2)|kidney(2)|large_intestine(1)|lung(1)|prostate(1)	10						CTGCTGCAATCCGTGGAAGAG	0.627000													19	24					0	0	0.008871	0	0
VPS26A	9559	broad.mit.edu	37	10	70928257	70928257	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr10:70928257C>T	ENST00000373382.1	+	9	1393	c.740C>T	c.(739-741)cCa>cTa	p.P247L	VPS26A_ENST00000395098.1_Intron|VPS26A_ENST00000263559.6_Missense_Mutation_p.P247L|VPS26A_ENST00000546041.1_Missense_Mutation_p.P230L|VPS26A_ENST00000541711.1_Missense_Mutation_p.P136L|VPS26A_ENST00000490696.1_3'UTR|VPS26A_ENST00000489794.1_Intron			O75436	VP26A_HUMAN	vacuolar protein sorting 26 homolog A (S. pombe)	247					retrograde transport, endosome to Golgi|vacuolar transport	cytosol|endosome membrane|retromer complex|vesicle	protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(2)	8						GAATCAATTCCAATAAGGCTA	0.318000													20	22					0	0	0.010504	0	0
ATRN	8455	broad.mit.edu	37	20	3540072	3540072	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr20:3540072T>C	ENST00000262919.5	+	7	1213	c.1145T>C	c.(1144-1146)cTa>cCa	p.L382P	ATRN_ENST00000446916.2_Missense_Mutation_p.L382P	NM_139321.2	NP_647537.1	O75882	ATRN_HUMAN	attractin	382					inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			breast(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	59						TGGCTTCCACTAAACCGTTCT	0.363000													26	54					0	0	0.005443	0	0
NUP188	23511	broad.mit.edu	37	9	131765638	131765638	+	Missense_Mutation	SNP	G	G	C			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr9:131765638G>C	ENST00000372577.2	+	38	4360	c.4339G>C	c.(4339-4341)Gag>Cag	p.E1447Q		NM_015354.1	NP_056169.1	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	1447					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|central_nervous_system(3)|endometrium(6)|kidney(4)|large_intestine(9)|lung(20)|ovary(6)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	60						GGCCTGCCTGGAGGAGGCGGA	0.572000													13	84					0	0	0.001855	0	0
HDAC4	9759	broad.mit.edu	37	2	240033331	240033331	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr2:240033331G>A	ENST00000345617.3	-	14	2645	c.1854C>T	c.(1852-1854)ccC>ccT	p.P618P	HDAC4_ENST00000541256.1_Silent_p.P592P|HDAC4_ENST00000543185.1_Silent_p.P202P	NM_006037.3	NP_006028.2	P56524	HDAC4_HUMAN	histone deacetylase 4	618					B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(5)	62		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		CGAAGGACACGGGGATGCCGG	0.692000													10	7					0	0	0.000978	0	0
PSRC1	84722	broad.mit.edu	37	1	109824519	109824519	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr1:109824519C>T	ENST00000438534.2	-	4	379	c.241G>A	c.(241-243)Gcc>Acc	p.A81T	PSRC1_ENST00000369903.2_Missense_Mutation_p.A81T|PSRC1_ENST00000409138.2_Missense_Mutation_p.A81T|PSRC1_ENST00000369904.3_Missense_Mutation_p.A81T|PSRC1_ENST00000369909.2_Missense_Mutation_p.A81T|PSRC1_ENST00000369907.3_Missense_Mutation_p.A81T|PSRC1_ENST00000409267.1_Missense_Mutation_p.A81T	NM_001005290.3	NP_001005290.1	Q6PGN9	PSRC1_HUMAN	proline/serine-rich coiled-coil 1	81					cell division|microtubule bundle formation|mitotic metaphase plate congression|negative regulation of cell growth|positive regulation of microtubule polymerization|positive regulation of transcription, DNA-dependent|regulation of mitotic spindle organization	cytosol|midbody|spindle pole	microtubule binding			endometrium(1)|large_intestine(1)|lung(2)|prostate(2)|skin(1)	7		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0286)|Lung(183;0.0658)|COAD - Colon adenocarcinoma(174;0.112)|Epithelial(280;0.188)|all cancers(265;0.213)		AGCCGGTTGGCCTCATCGAGG	0.682000													56	260					0	0	0.003610	0	0
UBE2I	7329	broad.mit.edu	37	16	1370212	1370212	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr16:1370212C>T	ENST00000355803.4	+	5	812	c.261C>T	c.(259-261)taC>taT	p.Y87Y	LA16c-358B7.3_ENST00000567829.1_RNA|UBE2I_ENST00000566587.1_Silent_p.Y87Y|UBE2I_ENST00000325437.5_Silent_p.Y87Y|UBE2I_ENST00000406620.1_Silent_p.Y87Y|UBE2I_ENST00000397515.2_Silent_p.Y87Y|UBE2I_ENST00000403747.2_Silent_p.Y87Y|UBE2I_ENST00000402301.1_Silent_p.Y87Y|LA16c-358B7.3_ENST00000568106.1_RNA|UBE2I_ENST00000397514.3_Silent_p.Y87Y	NM_194260.2	NP_919236.1	P63279	UBC9_HUMAN	ubiquitin-conjugating enzyme E2I	87				VYPS -> GVPF (in Ref. 6; AAC50603).	cell division|chromosome segregation|interspecies interaction between organisms|mitosis|negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|protein sumoylation	cytoplasm|PML body|synaptonemal complex	ATP binding|enzyme binding|ubiquitin-protein ligase activity			breast(1)|large_intestine(2)|skin(1)|upper_aerodigestive_tract(1)	5		Hepatocellular(780;0.00369)				CGAATGTGTACCCTTCGGGGA	0.552000													14	47					0	0	0.002450	0	0
DNAH8	1769	broad.mit.edu	37	6	38980260	38980260	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr6:38980260C>T	ENST00000359357.3	+	89	13164	c.12910C>T	c.(12910-12912)Cgt>Tgt	p.R4304C	DNAH8_ENST00000441566.1_Missense_Mutation_p.R4268C					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GTATGATGCTCGTATACCTCA	0.408000													16	58					0	0	0.004007	0	0
IRF2	3660	broad.mit.edu	37	4	185329312	185329312	+	Splice_Site	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr4:185329312C>T	ENST00000393593.3	-	6	736	c.529_splice	c.e6+1	p.V177_splice	IRF2_ENST00000512020.1_Intron	NM_002199.3	NP_002190.2	P14316	IRF2_HUMAN	interferon regulatory factor 2	177					blood coagulation|cell proliferation|interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	focal adhesion|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|ovary(2)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	22		all_lung(41;7.86e-14)|Lung NSC(41;1.87e-13)|Colorectal(36;0.00146)|Hepatocellular(41;0.00826)|Renal(120;0.00992)|Prostate(90;0.0115)|all_neural(102;0.0573)|all_hematologic(60;0.0592)		all cancers(43;3.94e-27)|Epithelial(43;5.3e-24)|OV - Ovarian serous cystadenocarcinoma(60;1.06e-10)|Colorectal(24;7.98e-07)|STAD - Stomach adenocarcinoma(60;3.95e-05)|GBM - Glioblastoma multiforme(59;8.3e-05)|COAD - Colon adenocarcinoma(29;0.000106)|BRCA - Breast invasive adenocarcinoma(30;0.000311)|LUSC - Lung squamous cell carcinoma(40;0.0128)|READ - Rectum adenocarcinoma(43;0.0419)		AACAGTTTACCTATGATGTTC	0.403000													27	29					0	0	0.006320	0	0
APOBEC3C	27350	broad.mit.edu	37	22	39411753	39411753	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr22:39411753C>T	ENST00000361441.3	+	2	451	c.171C>T	c.(169-171)aaC>aaT	p.N57N	APOBEC3D_ENST00000381568.4_Intron	NM_014508.2	NP_055323.2	Q9NRW3	ABC3C_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C	57					DNA demethylation|interspecies interaction between organisms|negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|protein binding|zinc ion binding			endometrium(1)|large_intestine(3)|lung(1)|skin(1)	6	Melanoma(58;0.04)					TCTTCCGAAACCAGGTAGCAC	0.527000													55	26					0	0	0.003610	0	0
SLC6A18	348932	broad.mit.edu	37	5	1239663	1239663	+	Silent	SNP	T	T	C			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr5:1239663T>C	ENST00000324642.3	+	6	954	c.831T>C	c.(829-831)agT>agC	p.S277S	SLC6A18_ENST00000296821.4_Silent_p.S272S	NM_182632.2	NP_872438.2	Q96N87	S6A18_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 18	277					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(4)|upper_aerodigestive_tract(1)	34	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CTTTTGCAAGTTACAACTCGC	0.582000													24	51					0	0	0.003330	0	0
LRRC4C	57689	broad.mit.edu	37	11	40136259	40136259	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr11:40136259G>A	ENST00000278198.2	-	2	3547	c.1584C>T	c.(1582-1584)atC>atT	p.I528I	LRRC4C_ENST00000528697.1_Silent_p.I528I|LRRC4C_ENST00000527150.1_Silent_p.I528I|LRRC4C_ENST00000530763.1_Silent_p.I528I			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	528					regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				ACCCAATGATGATTTTGGTAG	0.478000													48	39					0	0	0.003610	0	0
EIF2D	1939	broad.mit.edu	37	1	206770467	206770467	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr1:206770467C>T	ENST00000271764.2	-	12	1579	c.1371G>A	c.(1369-1371)tgG>tgA	p.W457*	EIF2D_ENST00000367114.3_Nonsense_Mutation_p.W333*	NM_006893.2	NP_008824.2	P41214	EIF2D_HUMAN	eukaryotic translation initiation factor 2D	457					intracellular protein transport	cytoplasm	protein binding|receptor activity|translation initiation factor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23						GAAGACTGTCCCATGGAAGCT	0.428000													15	8					0	0	0.008871	0	0
BAD	572	broad.mit.edu	37	11	64037608	64037608	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr11:64037608T>C	ENST00000544785.1	-	2	389	c.389A>G	c.(388-390)tAc>tGc	p.Y130C	BAD_ENST00000309032.3_3'UTR|BAD_ENST00000394532.3_3'UTR			Q92934	BAD_HUMAN	BCL2-associated agonist of cell death	0					activation of pro-apoptotic gene products|ADP metabolic process|ATP metabolic process|cellular response to hypoxia|cellular response to mechanical stimulus|cellular response to nicotine|glucose homeostasis|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|pore complex assembly|positive regulation of epithelial cell proliferation|positive regulation of glucokinase activity|positive regulation of insulin secretion|positive regulation of mitochondrial membrane potential|positive regulation of type B pancreatic cell development|regulation of mitochondrial membrane permeability|type B pancreatic cell proliferation	cytosol|mitochondrial outer membrane	caspase activator activity|phospholipid binding|protein kinase binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(1)	4						CTGAGGGAAGTACTTCCGCCC	0.602000													15	11					0	0	0.004990	0	0
RNF207	388591	broad.mit.edu	37	1	6279316	6279316	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr1:6279316C>T	ENST00000377939.4	+	18	1881	c.1754C>T	c.(1753-1755)cCg>cTg	p.P585L	RNF207_ENST00000377948.2_3'UTR|RNF207_ENST00000483336.1_3'UTR	NM_207396.2	NP_997279.2	Q6ZRF8	RN207_HUMAN	ring finger protein 207	585						intracellular	zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(7)|ovary(2)	16	Ovarian(185;0.0634)	all_cancers(23;1.22e-38)|all_epithelial(116;4.25e-22)|all_lung(118;7.95e-08)|Lung NSC(185;1.6e-06)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;4.84e-38)|GBM - Glioblastoma multiforme(13;5.77e-32)|OV - Ovarian serous cystadenocarcinoma(86;2.88e-19)|Colorectal(212;6.9e-08)|COAD - Colon adenocarcinoma(227;8.13e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.00311)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		GGAAGTGTCCCGGAAAAGAGA	0.502000													20	48					0	0	0.001882	0	0
POTEF	728378	broad.mit.edu	37	2	130832617	130832617	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr2:130832617G>A	ENST00000357462.5	-	15	2521	c.2428C>T	c.(2428-2430)Ctg>Ttg	p.L810L	POTEF_ENST00000409914.2_Silent_p.L810L			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	810	Actin-like.					cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						TTAGGGTTCAGGGTGGCCTCG	0.587000													58	175					0	0	0.003610	0	0
ARPC1B	10095	broad.mit.edu	37	7	98985735	98985735	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr7:98985735G>A	ENST00000451682.1	+	6	552	c.243G>A	c.(241-243)ctG>ctA	p.L81L	ARPC1A_ENST00000432884.2_3'UTR|ARPC1B_ENST00000252725.5_Silent_p.L81L|ARPC1B_ENST00000474880.1_3'UTR			O15143	ARC1B_HUMAN	actin related protein 2/3 complex, subunit 1B, 41kDa	81					cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(2)|lung(1)	11	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			TGTGGACGCTGAAGGGCCGCA	0.647000													19	98					0	0	0.010504	0	0
ETS2	2114	broad.mit.edu	37	21	40191596	40191596	+	Silent	SNP	A	A	G			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr21:40191596A>G	ENST00000360214.3	+	9	1441	c.981A>G	c.(979-981)ccA>ccG	p.P327P	ETS2_ENST00000360938.3_Silent_p.P327P	NM_001256295.1	NP_001243224.1	P15036	ETS2_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog 2	327					positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				TCAATAAGCCAACCATGTCTT	0.532000													9	16					0	0	0.006214	0	0
PCF11	51585	broad.mit.edu	37	11	82877448	82877448	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr11:82877448C>T	ENST00000298281.4	+	5	1961	c.1509C>T	c.(1507-1509)ccC>ccT	p.P503P		NM_015885.3	NP_056969.2	O94913	PCF11_HUMAN	PCF11 cleavage and polyadenylation factor subunit	503					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				cervix(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(22)|ovary(1)|urinary_tract(1)	33						GGCGGTCACCCAAACGAAGGC	0.458000													4	64					0	0	0.000602	0	0
SLC38A1	81539	broad.mit.edu	37	12	46623403	46623403	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr12:46623403C>T	ENST00000398637.5	-	4	836	c.142G>A	c.(142-144)Gaa>Aaa	p.E48K	SLC38A1_ENST00000549049.1_Missense_Mutation_p.E48K|SLC38A1_ENST00000546893.1_Missense_Mutation_p.E48K|SLC38A1_ENST00000549633.1_5'UTR|SLC38A1_ENST00000439706.1_Missense_Mutation_p.E48K|SLC38A1_ENST00000552197.1_Missense_Mutation_p.E48K	NM_001077484.1|NM_001278387.1|NM_001278388.1|NM_001278389.1|NM_030674.3	NP_001070952.1|NP_001265316.1|NP_001265317.1|NP_001265318.1|NP_109599.3	Q9H2H9	S38A1_HUMAN	solute carrier family 38, member 1	48					cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			NS(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(2)	23	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)			CTTCTACTTTCACGATCAGAA	0.279000													52	63					0	0	0.003610	0	0
FANCE	2178	broad.mit.edu	37	6	35427183	35427183	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr6:35427183C>T	ENST00000229769.2	+	6	1374	c.1189C>T	c.(1189-1191)Cct>Tct	p.P397S		NM_021922.2	NP_068741.1	Q9HB96	FANCE_HUMAN	Fanconi anemia, complementation group E	397					DNA repair	nucleoplasm	protein binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|ovary(1)|skin(2)	13						ATATACATACCCTGTCTGCAG	0.567000			"""N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				21	51					0	0	0.010504	0	0
CALCOCO1	57658	broad.mit.edu	37	12	54117527	54117527	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr12:54117527G>A	ENST00000548263.1	-	4	348	c.300C>T	c.(298-300)ttC>ttT	p.F100F	CALCOCO1_ENST00000550804.1_Silent_p.F100F|CALCOCO1_ENST00000430117.2_Intron|CALCOCO1_ENST00000262059.4_Silent_p.F100F			Q9P1Z2	CACO1_HUMAN	calcium binding and coiled-coil domain 1	100	N-terminal AD (CTNNB1 binding site) (By similarity).				steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			NS(2)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	28						TCACATATCGGAACTGGTAGA	0.607000													17	21					0	0	0.007413	0	0
DNAH9	1770	broad.mit.edu	37	17	11648187	11648187	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr17:11648187C>T	ENST00000262442.3	+	31	6253	c.6185C>T	c.(6184-6186)cCt>cTt	p.P2062L	DNAH9_ENST00000454412.2_Missense_Mutation_p.P2062L	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2062					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGAGGAGACCCTGACCGGCCT	0.577000													15	19					0	0	0.004007	0	0
IQCJ	654502	broad.mit.edu	37	3	158983180	158983180	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr3:158983180C>T	ENST00000482126.1	+	4	492	c.387C>T	c.(385-387)ctC>ctT	p.L129L	IQCJ-SCHIP1_ENST00000476809.1_Intron|IQCJ-SCHIP1_ENST00000467442.1_Intron|IQCJ-SCHIP1_ENST00000485419.1_Intron|IQCJ_ENST00000451172.1_Silent_p.L156L	NM_001197100.1	NP_001184029.1			IQ motif containing J											cervix(1)|endometrium(2)|large_intestine(2)|lung(10)	15			LUSC - Lung squamous cell carcinoma(72;0.00523)|Lung(72;0.00534)			TTGGTTTTCTCACCCTCCAGT	0.478000													40	26					0	0	0.006230	0	0
KRT31	3881	broad.mit.edu	37	17	39551240	39551240	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr17:39551240G>A	ENST00000251645.2	-	6	1009	c.957C>T	c.(955-957)acC>acT	p.T319T		NM_002277.2	NP_002268.2	Q15323	K1H1_HUMAN	keratin 31	319	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	31		Breast(137;0.000496)				ACTCCACGTTGGTGATCAGGC	0.617000													24	37					0	0	0.002780	0	0
KRT18	3875	broad.mit.edu	37	12	53344588	53344588	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr12:53344588C>T	ENST00000550600.1	+	4	609	c.555C>T	c.(553-555)ctC>ctT	p.L185L	KRT18_ENST00000388837.2_Silent_p.L185L|KRT18_ENST00000388835.3_Silent_p.L185L			P05783	K1C18_HUMAN	keratin 18	185	Coil 1B.|Necessary for interaction with PNN.|Rod.				anatomical structure morphogenesis|cell cycle|Golgi to plasma membrane CFTR protein transport|interspecies interaction between organisms|negative regulation of apoptosis	centriolar satellite|keratin filament|perinuclear region of cytoplasm	protein binding|structural molecule activity			central_nervous_system(1)|large_intestine(2)|lung(4)|prostate(3)|skin(1)	11						TCCATGGGCTCCGCAAGGTCA	0.537000													9	11					0	0	0.008291	0	0
SLC7A10	56301	broad.mit.edu	37	19	33703818	33703818	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr19:33703818G>A	ENST00000253188.3	-	3	593	c.447C>T	c.(445-447)ccC>ccT	p.P149P		NM_019849.2	NP_062823.1	Q9NS82	AAA1_HUMAN	solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10	149					blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	18	Esophageal squamous(110;0.137)					TGGGGAACACGGGCTGCAGCA	0.612000													44	11					0	0	0.008740	0	0
CCKAR	886	broad.mit.edu	37	4	26491812	26491812	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr4:26491812C>T	ENST00000295589.3	-	1	272	c.78G>A	c.(76-78)acG>acA	p.T26T		NM_000730.2	NP_000721.1	P32238	CCKAR_HUMAN	cholecystokinin A receptor	26					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			NS(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|pancreas(1)|skin(1)	29		Breast(46;0.0503)			Ceruletide(DB00403)	AGCAGAAAAGCGTCTCATTTT	0.478000													13	31					0	0	0.001855	0	0
WDR49	151790	broad.mit.edu	37	3	167249024	167249024	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr3:167249024G>A	ENST00000308378.3	-	9	1346	c.1041C>T	c.(1039-1041)ccC>ccT	p.P347P	WDR49_ENST00000479765.1_Intron|WDR49_ENST00000476376.1_Silent_p.P172P|WDR49_ENST00000453925.2_Silent_p.P411P	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	347										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						TGGGGTGGGAGGGTTGGCTTC	0.428000													18	66					0	0	0.007413	0	0
HEXDC	284004	broad.mit.edu	37	17	80377712	80377712	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr17:80377712C>T	ENST00000337014.6	+	2	511	c.37C>T	c.(37-39)Cat>Tat	p.H13Y	HEXDC_ENST00000327949.9_Missense_Mutation_p.H13Y|HEXDC_ENST00000577944.1_Missense_Mutation_p.H13Y	NM_173620.2	NP_775891.2	Q8WVB3	HEXDC_HUMAN	hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing	13					carbohydrate metabolic process	cytoplasm|nucleus	beta-N-acetylhexosaminidase activity|cation binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	16	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			GAGATTAGTTCATTTAGACCT	0.433000													15	12					0	0	0.006122	0	0
APBA2	321	broad.mit.edu	37	15	29346463	29346463	+	Missense_Mutation	SNP	G	G	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr15:29346463G>T	ENST00000558402.1	+	5	975	c.376G>T	c.(376-378)Gca>Tca	p.A126S	APBA2_ENST00000561069.1_Missense_Mutation_p.A126S|APBA2_ENST00000558259.1_Missense_Mutation_p.A126S|APBA2_ENST00000411764.1_Missense_Mutation_p.A126S|APBA2_ENST00000558330.1_Missense_Mutation_p.A126S			Q99767	APBA2_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 2	126					nervous system development|protein transport		protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|liver(2)|lung(33)|stomach(1)|urinary_tract(1)	59		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		GGCCCACAGTGCACACCCTGT	0.657000													16	62					9.16793e-09	9.61099e-09	0.004990	1	0
SNAP91	9892	broad.mit.edu	37	6	84375219	84375219	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr6:84375219C>T	ENST00000428679.2	-	3	805	c.212G>A	c.(211-213)aGc>aAc	p.S71N	SNAP91_ENST00000195649.6_Missense_Mutation_p.S71N|SNAP91_ENST00000521743.1_Missense_Mutation_p.S71N|SNAP91_ENST00000437520.1_Missense_Mutation_p.S71N|SNAP91_ENST00000521485.1_Missense_Mutation_p.S71N|SNAP91_ENST00000520302.1_Missense_Mutation_p.S71N|SNAP91_ENST00000369694.2_Missense_Mutation_p.S71N|SNAP91_ENST00000520213.1_Missense_Mutation_p.S71N|SNAP91_ENST00000439399.2_Missense_Mutation_p.S71N			O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa	71	ENTH.				clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(22)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		AACCACCCAGCTACTGTTTGT	0.403000													33	76					0	0	0.009535	0	0
ZNF682	91120	broad.mit.edu	37	19	20135111	20135111	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr19:20135111C>T	ENST00000397165.2	-	2	238	c.78G>A	c.(76-78)caG>caA	p.Q26Q	ZNF682_ENST00000595736.1_Intron|ZNF682_ENST00000358523.5_5'UTR|ZNF682_ENST00000593468.1_Silent_p.Q26Q|ZNF682_ENST00000397162.1_5'UTR|ZNF682_ENST00000597972.1_Silent_p.Q32Q|ZNF682_ENST00000596019.1_Silent_p.Q26Q	NM_033196.2	NP_149973.1	O95780	ZN682_HUMAN	zinc finger protein 682	26	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	14						TATACAAACTCTGCTGAGCAG	0.388000													32	8					0	0	0.002445	0	0
MUC3A	4584	broad.mit.edu	37	7	100608884	100608884	+	Missense_Mutation	SNP	G	G	A	rs73163797	by1000genomes	TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr7:100608884G>A	ENST00000319509.7	+	7	2263	c.2263G>A	c.(2263-2265)Gcg>Acg	p.A755T	RP11-395B7.2_ENST00000420080.1_RNA					mucin 3A, cell surface associated									p.A755T(1)		breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						GAGCGGTCCCGCGTGTCGGTA	0.667000													10	26					0	0	0.004990	0	0
PRR11	55771	broad.mit.edu	37	17	57270947	57270947	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr17:57270947C>T	ENST00000262293.4	+	5	809	c.497C>T	c.(496-498)cCt>cTt	p.P166L		NM_018304.3	NP_060774.2	Q96HE9	PRR11_HUMAN	proline rich 11	166										breast(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|pancreas(1)	16	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					CTGATCACCCCTGGAGACTCC	0.542000													23	31					0	0	0.002299	0	0
LMCD1	29995	broad.mit.edu	37	3	8607123	8607123	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr3:8607123C>T	ENST00000157600.3	+	5	961	c.729C>T	c.(727-729)tgC>tgT	p.C243C	LMCD1_ENST00000397386.3_Silent_p.C131C|LMCD1_ENST00000454244.1_Silent_p.C170C|LMCD1-AS1_ENST00000439407.1_RNA	NM_014583.2	NP_055398.1	Q9NZU5	LMCD1_HUMAN	LIM and cysteine-rich domains 1	243	LIM zinc-binding 1.				positive regulation of calcineurin-NFAT signaling pathway|regulation of cardiac muscle hypertrophy|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	transcription corepressor activity|zinc ion binding			breast(2)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)	16				OV - Ovarian serous cystadenocarcinoma(96;0.124)		TCCAGGTCTGCGAGCTCTGCA	0.592000													31	165					0	0	0.002836	0	0
C10orf88	80007	broad.mit.edu	37	10	124697643	124697643	+	Silent	SNP	C	C	G	rs145904265	byFrequency	TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr10:124697643C>G	ENST00000481909.1	-	5	905	c.681G>C	c.(679-681)tcG>tcC	p.S227S	C10orf88_ENST00000368891.5_5'UTR	NM_024942.3	NP_079218.2	Q9H8K7	CJ088_HUMAN	chromosome 10 open reading frame 88	227										breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)	18		all_neural(114;0.0765)|Lung NSC(174;0.163)|all_lung(145;0.205)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0735)		TGCCCAACACCGACTGAAGCT	0.368000													15	12					0	0	0.004990	0	0
GABBR1	2550	broad.mit.edu	37	6	29571439	29571439	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr6:29571439G>A	ENST00000377034.4	-	23	3102	c.2767C>T	c.(2767-2769)Cgc>Tgc	p.R923C	GABBR1_ENST00000377012.4_Missense_Mutation_p.R806C|GABBR1_ENST00000376977.3_3'UTR|GABBR1_ENST00000355973.3_Missense_Mutation_p.R806C|GABBR1_ENST00000377016.4_Missense_Mutation_p.R861C	NM_001470.2	NP_001461.1	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 1	923				Missing (in Ref. 7; CAA09031).	gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			endometrium(3)|kidney(1)|large_intestine(13)|liver(1)|lung(16)|ovary(5)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47					Baclofen(DB00181)|Progabide(DB00837)	CGCCGGGAGCGGAGCTGCTGC	0.632000													6	12					0	0	0.003080	0	0
MRE11A	4361	broad.mit.edu	37	11	94192583	94192583	+	Silent	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr11:94192583G>A	ENST00000323929.3	-	13	1713	c.1491C>T	c.(1489-1491)atC>atT	p.I497I	MRE11A_ENST00000323977.3_Silent_p.I497I|MRE11A_ENST00000407439.3_Silent_p.I500I|MRE11A_ENST00000393241.4_Silent_p.I497I	NM_005591.3	NP_005582.1	P49959	MRE11_HUMAN	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	497					DNA duplex unwinding|double-strand break repair via homologous recombination|double-strand break repair via nonhomologous end joining|negative regulation of DNA endoreduplication|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|sister chromatid cohesion|telomere maintenance via telomerase	Mre11 complex|nucleoplasm	3'-5' exonuclease activity|double-stranded DNA binding|manganese ion binding|protein C-terminus binding|single-stranded DNA specific endodeoxyribonuclease activity			breast(5)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	29		Acute lymphoblastic leukemia(157;2.37e-05)|all_hematologic(158;0.00824)				CCTCCTCATCGATTTTGTCTT	0.353000								Homologous recombination	Ataxia-Telangiectasia-Like Disorder				14	48					0	0	0.004007	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14796355	14796355	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr18:14796355G>A	ENST00000358984.4	+	18	2048	c.1868G>A	c.(1867-1869)aGg>aAg	p.R623K	ANKRD30B_ENST00000447268.2_Silent_p.K613K|ANKRD30B_ENST00000579292.1_Intron	NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	623										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						ACCTGTGGAAGGAAAGTTTCT	0.274000													4	3					0	0	0.009096	0	0
WDR17	116966	broad.mit.edu	37	4	177067188	177067188	+	Silent	SNP	T	T	A			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr4:177067188T>A	ENST00000393643.2	+	12	1824	c.1572T>A	c.(1570-1572)gtT>gtA	p.V524V	WDR17_ENST00000507824.2_Silent_p.V531V|WDR17_ENST00000508596.1_Silent_p.V524V|WDR17_ENST00000280190.4_Silent_p.V548V	NM_170710.4	NP_733828.2	Q8IZU2	WDR17_HUMAN	WD repeat domain 17	548										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(18)|lung(46)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	92		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		ATGTTCGTGTTTATTATGTAG	0.353000													21	28					0	0	0.002780	0	0
EPHA6	285220	broad.mit.edu	37	3	97356761	97356761	+	Silent	SNP	C	C	T			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr3:97356761C>T	ENST00000389672.5	+	14	2657	c.2619C>T	c.(2617-2619)ctC>ctT	p.L873L	EPHA6_ENST00000514100.1_Silent_p.L265L|EPHA6_ENST00000442602.2_3'UTR|EPHA6_ENST00000502694.1_Silent_p.L265L	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	778	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						TCGGAATGCTCCGAGGCATTG	0.428000													24	164					0	0	0.007291	0	0
FGFRL1	53834	broad.mit.edu	37	4	1019055	1019056	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr4:1019055_1019056delCA	ENST00000398484.2	+	8	2015_2016	c.1435_1436delCA	c.(1435-1437)cfs	p.H479fs	FGFRL1_ENST00000504138.1_Frame_Shift_Del_p.H479fs|FGFRL1_ENST00000510644.1_Frame_Shift_Del_p.H479fs|FGFRL1_ENST00000264748.6_Frame_Shift_Del_p.H479fs			Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	479	His-rich.				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			cacagacatccacacacacaca	0.584													6	13	---	---	---	---					
RP11-608O21.1	0	broad.mit.edu	37	4	19815895	19815895	+	RNA	DEL	A	A	-	rs145239076		TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr4:19815895delA	ENST00000511431.1	+	0	288																											TCTGGGCTGTaaaaaaaaaaa	0.413													4	1	---	---	---	---					
GZMA	3001	broad.mit.edu	37	5	54405901	54405901	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr5:54405901delC	ENST00000274306.6	+	5	715	c.680delC	c.(679-681)tcfs	p.S227fs		NM_006144.3	NP_006135.1	P12544	GRAA_HUMAN	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	227	Peptidase S1.				cleavage of lamin|cytolysis|immune response|negative regulation of DNA binding|negative regulation of endodeoxyribonuclease activity|negative regulation of oxidoreductase activity|positive regulation of apoptosis	extracellular region|immunological synapse|nucleus	protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	25		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				GGGGTCACTTCCTTTGGCCTT	0.483													45	59	---	---	---	---					
LINC00933	100506874	broad.mit.edu	37	15	85115422	85115423	+	RNA	INS	-	-	T	rs60884952		TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr15:85115422_85115423insT	ENST00000557887.1	+	0	0_1					NR_038273.1|NR_038274.1																						ACATAATGCTCttttttttttt	0.391													2	4	---	---	---	---					
SHCBP1	79801	broad.mit.edu	37	16	46615932	46615933	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-DA-A1I8-06A-11D-A197-08	TCGA-DA-A1I8-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64dd81e1-35fa-4579-8a4c-f7486adbb949	5c001667-5412-4e44-806e-a1040f0f300a	g.chr16:46615932_46615933delCT	ENST00000303383.3	-	13	1993_1994	c.1727_1728delAG	c.(1726-1728)gfs	p.E576fs		NM_024745.4	NP_079021.3	Q8NEM2	SHCBP_HUMAN	SHC SH2-domain binding protein 1	576										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(37;0.00404)|all_epithelial(9;0.00527)|all_lung(18;0.0413)|Lung NSC(13;0.213)				CCACATCTGGCTCTCCACTTGT	0.381													12	122	---	---	---	---