Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KIAA1324	57535	broad.mit.edu	37	1	109716420	109716420	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:109716420G>A	ENST00000369939.3	+	7	1096	c.913G>A	c.(913-915)Gaa>Aaa	p.E305K	KIAA1324_ENST00000529753.1_Intron	NM_020775.4	NP_065826.2	Q6UXG2	K1324_HUMAN	KIAA1324	305					macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		AAATAAAGGAGAAACTTCTTG	0.478000													7	36					0	0	1	0	0
BTN2A3P	54718	broad.mit.edu	37	6	26422353	26422353	+	RNA	SNP	C	C	T	rs141013110		TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:26422353C>T	ENST00000466808.2	+	0	7																		p.P3S(2)									GCTCATGGAACCAGCTGCTGC	0.622000													4	96					0	0	1	0	0
EML2	24139	broad.mit.edu	37	19	46124878	46124878	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:46124878G>C	ENST00000536630.1	-	13	1438	c.1300C>G	c.(1300-1302)Cag>Gag	p.Q434E	EML2_ENST00000245925.3_Missense_Mutation_p.Q287E|EML2_ENST00000586902.1_5'UTR|EML2_ENST00000587152.1_Missense_Mutation_p.Q488E|EML2_ENST00000589876.1_Missense_Mutation_p.Q287E	NM_001193269.1	NP_001180198.1	O95834	EMAL2_HUMAN	echinoderm microtubule associated protein like 2	287					sensory perception of sound|visual perception	cytoplasm|intracellular membrane-bounded organelle|microtubule|microtubule associated complex	catalytic activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(13)|ovary(1)|urinary_tract(1)	31		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00553)|GBM - Glioblastoma multiforme(486;0.131)|Epithelial(262;0.197)		AGCACCGCCTGTGTGATACGG	0.667000													8	6					0	0	1	0	0
SAAL1	113174	broad.mit.edu	37	11	18110965	18110965	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr11:18110965G>T	ENST00000524803.1	-	7	731	c.682C>A	c.(682-684)Cag>Aag	p.Q228K	SAAL1_ENST00000533851.1_5'UTR|SAAL1_ENST00000300013.4_Missense_Mutation_p.Q228K|SAAL1_ENST00000529318.1_Missense_Mutation_p.Q228K			Q96ER3	SAAL1_HUMAN	serum amyloid A-like 1	228					acute-phase response	extracellular region	binding			breast(2)|large_intestine(5)|lung(8)	15						TCCAGAGGCTGAGCAGCCCCA	0.512000													19	39					0.000958276	0.00106695	1	1	0
PAF1	54623	broad.mit.edu	37	19	39877178	39877178	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:39877178G>A	ENST00000221265.3	-	13	1457	c.1127C>T	c.(1126-1128)cCg>cTg	p.P376L	PAF1_ENST00000221266.7_Missense_Mutation_p.P343L|PAF1_ENST00000595564.1_Missense_Mutation_p.P366L	NM_019088.3	NP_061961.2	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	376	Glu-rich.				histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|urinary_tract(2)	17	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			ttcctcctccGGTTCGTGGTT	0.572000													10	21					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110817227	110817227	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr13:110817227C>T	ENST00000375820.4	-	46	4253	c.4132G>A	c.(4132-4134)Ggc>Agc	p.G1378S		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1378	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCTTTCGGGCCTGGCAGTCCC	0.642000													4	10					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55534084	55534084	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr8:55534084C>A	ENST00000220676.1	+	2	706	c.558C>A	c.(556-558)caC>caA	p.H186Q		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	186	Doublecortin 2.				axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTCTACAGCACCTGACAGAGG	0.602000													66	158					6.8682e-38	9.76007e-38	1	1	0
PTPRB	5787	broad.mit.edu	37	12	70956768	70956768	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr12:70956768C>A	ENST00000334414.6	-	16	4068	c.4024G>T	c.(4024-4026)Ggg>Tgg	p.G1342W	PTPRB_ENST00000538708.1_Missense_Mutation_p.G1034W|PTPRB_ENST00000261266.5_Missense_Mutation_p.G1124W|PTPRB_ENST00000451516.2_Missense_Mutation_p.G1034W|PTPRB_ENST00000550358.1_Missense_Mutation_p.G1254W|PTPRB_ENST00000550857.1_Missense_Mutation_p.G1034W|PTPRB_ENST00000551525.1_Missense_Mutation_p.G1341W	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1124	Fibronectin type-III 15.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TGGAGATTCCCATCTGGGTTG	0.512000													6	27					0.00198382	0.00216417	1	1	0
TMEM190	147744	broad.mit.edu	37	19	55889022	55889022	+	Silent	SNP	C	C	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:55889022C>A	ENST00000291934.3	+	3	174	c.156C>A	c.(154-156)ccC>ccA	p.P52P	CTD-2105E13.15_ENST00000595064.1_RNA	NM_139172.1	NP_631911.1	Q8WZ59	TM190_HUMAN	transmembrane protein 190	52	P-type.					integral to membrane				large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	5	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		TCGATAGCCCCAACCTCTGCC	0.672000													30	153					7.26314e-15	1.00567e-14	1	1	0
FBP2	8789	broad.mit.edu	37	9	97356004	97356004	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr9:97356004G>A	ENST00000375337.3	-	1	71	c.5C>T	c.(4-6)aCg>aTg	p.T2M		NM_003837.2	NP_003828.2	O00757	F16P2_HUMAN	fructose-1,6-bisphosphatase 2	2					fructose metabolic process|gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|metal ion binding			endometrium(1)|large_intestine(3)|lung(5)	9		Acute lymphoblastic leukemia(62;0.136)				GCTTCTGTCCGTCATTTTGGC	0.552000													3	43					0	0	1	0	0
CTSG	1511	broad.mit.edu	37	14	25043609	25043609	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr14:25043609C>T	ENST00000216336.2	-	4	472	c.436G>A	c.(436-438)Ggc>Agc	p.G146S		NM_001911.2	NP_001902.1	P08311	CATG_HUMAN	cathepsin G	146	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			autonomic_ganglia(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(265;0.0269)		CTGCCCCAGCCGGCCACAGTG	0.612000													25	118					0	0	1	0	0
GOLGA2P9	440518	broad.mit.edu	37	19	22785310	22785310	+	RNA	SNP	A	A	G			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:22785310A>G	ENST00000600260.1	+	0	1486					NR_033899.1																						GCCATGGAGAAACTGCAGGTG	0.627000													10	5					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44933207	44933207	+	Silent	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:44933207C>T	ENST00000291187.4	-	6	2053	c.1731G>A	c.(1729-1731)cgG>cgA	p.R577R	ZNF229_ENST00000591289.1_Intron|CTC-512J12.4_ENST00000588655.1_RNA|ZNF229_ENST00000588931.1_Silent_p.R583R	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	583					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				GGTCTGAATTCCGCCGGAAGC	0.572000													31	19					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453987	140453987	+	Splice_Site	SNP	T	T	G			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr7:140453987T>G	ENST00000288602.6	-	14	1801	c.1741_splice	c.e14+1	p.N581_splice		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	581	Protein kinase.		N -> D (in CFC syndrome).|N -> S (in a colorectal adenocarcinoma sample; somatic mutation).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	GGAAGGATACTATTACTCTTG	0.373000		61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				31	30					0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92471145	92471145	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr14:92471145G>C	ENST00000267622.4	-	11	3548	c.3175C>G	c.(3175-3177)Cag>Gag	p.Q1059E		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1059					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		TGAATAATCTGAGTTAGTTTA	0.338000			T	PDGFRB	AML								8	39					0	0	1	0	0
XKR6	286046	broad.mit.edu	37	8	10755649	10755649	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr8:10755649G>T	ENST00000416569.2	-	3	1765	c.1739C>A	c.(1738-1740)cCa>cAa	p.P580Q	XKR6_ENST00000304437.2_Missense_Mutation_p.P301Q	NM_173683.3	NP_775954.2	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related family, member 6	580						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(8)|ovary(2)|prostate(1)|skin(3)	31				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		GGGCCCTTCTGGGAGGTAAGG	0.522000													3	21					0.004672	0.00504576	1	1	0
MICB	4277	broad.mit.edu	37	6	31474904	31474904	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:31474904G>A	ENST00000252229.6	+	4	798	c.719G>A	c.(718-720)cGt>cAt	p.R240H	MICB_ENST00000538442.1_Missense_Mutation_p.R208H|MICB_ENST00000399150.3_Missense_Mutation_p.R197H	NM_005931.3	NP_005922.2	Q29980	MICB_HUMAN	MHC class I polypeptide-related sequence B	240	Ig-like C1-type.				antigen processing and presentation|cytolysis|gamma-delta T cell activation|immune response|immune response-activating cell surface receptor signaling pathway|interspecies interaction between organisms|negative regulation of defense response to virus by host|response to heat|response to oxidative stress|response to retinoic acid	integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)	13						CTGACCTGGCGTCAGGATGGG	0.582000													22	31					0	0	1	0	0
CYP2S1	29785	broad.mit.edu	37	19	41700534	41700534	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:41700534G>T	ENST00000310054.4	+	2	479	c.263G>T	c.(262-264)cGg>cTg	p.R88L	CYP2S1_ENST00000542619.1_5'UTR	NM_030622.6	NP_085125.1	Q96SQ9	CP2S1_HUMAN	cytochrome P450, family 2, subfamily S, polypeptide 1	88					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(2)	14						GAGGCTGTGCGGGAGGCCCTG	0.632000													15	27					1.49906e-05	1.74084e-05	1	1	0
EPHA8	2046	broad.mit.edu	37	1	22922632	22922632	+	Silent	SNP	G	G	T	rs144628022		TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:22922632G>T	ENST00000166244.3	+	9	1803	c.1731G>T	c.(1729-1731)tcG>tcT	p.S577S		NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	577						integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TCCAGGACTCGGACGAGGAGA	0.667000													12	22					5.50884e-06	6.76085e-06	1	1	0
KCNJ4	3761	broad.mit.edu	37	22	38823055	38823055	+	Silent	SNP	C	C	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr22:38823055C>A	ENST00000303592.3	-	2	1341	c.1083G>T	c.(1081-1083)ctG>ctT	p.L361L	RP3-434P1.6_ENST00000433230.1_RNA	NM_004981.1|NM_152868.2	NP_004972.1|NP_690607.1	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 4	361					synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding			endometrium(7)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	23	Melanoma(58;0.0286)					GTGGGGCGGGCAGCACGGTGA	0.642000													6	62					0.0293803	0.0305104	1	1	0
TRIP11	9321	broad.mit.edu	37	14	92471090	92471090	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr14:92471090G>A	ENST00000267622.4	-	11	3603	c.3230C>T	c.(3229-3231)tCa>tTa	p.S1077L		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1077					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		ATGGGAAGTTGAAGAAATTCT	0.368000			T	PDGFRB	AML								12	47					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	77885617	77885617	+	Silent	SNP	G	G	T	rs139352828		TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr7:77885617G>T	ENST00000354212.4	-	10	1943	c.1690C>A	c.(1690-1692)Cgg>Agg	p.R564R	MAGI2_ENST00000536571.1_Silent_p.R396R|MAGI2_ENST00000535697.1_Silent_p.R401R|MAGI2_ENST00000419488.1_Silent_p.R564R|MAGI2_ENST00000522391.1_Silent_p.R564R	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	564						cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TGAGGCGGCCGATCTGTTATA	0.502000													6	35					0.0293803	0.0305104	1	1	0
THSD7A	221981	broad.mit.edu	37	7	11485803	11485803	+	Silent	SNP	C	C	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr7:11485803C>A	ENST00000423059.3	-	13	3200	c.2949G>T	c.(2947-2949)ctG>ctT	p.L983L	AC004538.3_ENST00000445839.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	983	TSP type-1 10.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CTTTCATTCCCAGCAACACTT	0.433000										HNSCC(18;0.044)			4	86					1.23904e-05	1.45453e-05	1	1	0
TEKT5	146279	broad.mit.edu	37	16	10770001	10770001	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr16:10770001C>T	ENST00000283025.2	-	5	972	c.901G>A	c.(901-903)Gac>Aac	p.D301N		NM_144674.1	NP_653275.1	Q96M29	TEKT5_HUMAN	tektin 5	301					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)	34						TTGATGTTGTCGTTACTGAAC	0.552000													6	27					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55106687	55106687	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:55106687G>A	ENST00000453777.1	+	5	651	c.481G>A	c.(481-483)Gaa>Aaa	p.E161K	LILRA1_ENST00000473156.1_3'UTR|LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000251372.3_Missense_Mutation_p.E161K|LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000418536.2_Intron	NM_001278318.1	NP_001265247.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	161	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		TAAGGAAGGAGAAGATGAACA	0.592000													94	67					0	0	1	0	0
BAG6	7917	broad.mit.edu	37	6	31606981	31606981	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:31606981C>T	ENST00000404765.2	-	26	3705	c.3416G>A	c.(3415-3417)cGa>cAa	p.R1139Q	BAG6_ENST00000362049.6_Missense_Mutation_p.R1054Q|BAG6_ENST00000439687.2_Missense_Mutation_p.R880Q|BAG6_ENST00000375976.4_Missense_Mutation_p.R1103Q|BAG6_ENST00000211379.5_Missense_Mutation_p.R1103Q|BAG6_ENST00000375964.6_Missense_Mutation_p.R1109Q			P46379	BAG6_HUMAN	BCL2-associated athanogene 6	1109					apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(2)|pancreas(2)|skin(3)|urinary_tract(2)	36						TTCCTGCAGTCGTTTTTGTAT	0.532000													10	12					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179615995	179615995	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr2:179615995G>A	ENST00000360870.5	-	46	11354	c.11132C>T	c.(11131-11133)aCa>aTa	p.T3711I	TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000591111.1_Intron|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342992.6_Intron|TTN_ENST00000460472.2_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9557	Ig-like 22.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCCATTAATGTTTTTCTAGC	0.353000													17	49					0	0	1	0	0
PFKL	5211	broad.mit.edu	37	21	45742035	45742035	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr21:45742035A>G	ENST00000403390.1	+	15	1499	c.1499A>G	c.(1498-1500)cAc>cGc	p.H500R	PFKL_ENST00000349048.4_Missense_Mutation_p.H453R			P17858	K6PL_HUMAN	phosphofructokinase, liver	453					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	23				Colorectal(79;0.0811)		GTAGGCTGGCACGACGTGGCC	0.701000													34	24					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162513	90162513	+	RNA	SNP	T	T	C			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr16:90162513T>C	ENST00000564451.1	+	0	1866				TUBB8P7_ENST00000567960.1_RNA														p.N415N(2)									GCAACATGAATGACCTGGTGT	0.537000													5	47					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2962795	2962795	+	Missense_Mutation	SNP	C	C	A	rs146070546		TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr7:2962795C>A	ENST00000396946.4	-	16	2516	c.2113G>T	c.(2113-2115)Ggc>Tgc	p.G705C		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	705	PDZ.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TCACGGAGGCCGGCTTTCTCG	0.652000			Mis		DLBCL								3	37					2.56e-06	3.21488e-06	1	1	0
ZNF733P	643955	broad.mit.edu	37	7	62752318	62752318	+	RNA	SNP	T	T	C	rs139668717	by1000genomes	TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr7:62752318T>C	ENST00000331425.6	-	0	1117					NR_003952.1																						ACATTCTTCATATGTGTAGGG	0.433000													3	20					0	0	1	0	0
MAP3K7	6885	broad.mit.edu	37	6	91226264	91226264	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:91226264C>T	ENST00000369329.3	-	17	1938	c.1777G>A	c.(1777-1779)Gag>Aag	p.E593K	MAP3K7_ENST00000369320.1_Missense_Mutation_p.E247K|MAP3K7_ENST00000369325.3_3'UTR|MAP3K7_ENST00000369332.3_Missense_Mutation_p.E566K|MAP3K7_ENST00000479630.1_5'UTR|MAP3K7_ENST00000369327.3_3'UTR	NM_145331.2	NP_663304.1	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	593					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding	p.E566K(1)|p.E593K(1)		endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	28		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		CTGATGACCTCTAGTTGTTTT	0.378000													21	50					0	0	1	0	0
GLB1L2	89944	broad.mit.edu	37	11	134244581	134244581	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr11:134244581C>A	ENST00000535456.2	+	18	1981	c.1793C>A	c.(1792-1794)cCa>cAa	p.P598Q	GLB1L2_ENST00000529077.1_3'UTR|GLB1L2_ENST00000339772.7_Missense_Mutation_p.P598Q|GLB1L2_ENST00000389881.3_Missense_Mutation_p.P598Q	NM_138342.3	NP_612351.2	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2	598					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		CTTTACCTCCCAGGTCCCTGG	0.597000													7	67					0.0293803	0.0305104	1	1	0
IGSF21	84966	broad.mit.edu	37	1	18691938	18691938	+	Silent	SNP	C	C	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:18691938C>A	ENST00000251296.1	+	6	1145	c.762C>A	c.(760-762)ccC>ccA	p.P254P		NM_032880.4	NP_116269.3	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21	254						extracellular region				endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	40		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		CCCCAGATCCCAACATCCTCC	0.637000													6	164					8.12818e-05	9.33876e-05	1	1	0
SLC6A11	6538	broad.mit.edu	37	3	10960063	10960063	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr3:10960063G>T	ENST00000254488.2	+	8	1111	c.1045G>T	c.(1045-1047)Ggg>Tgg	p.G349W		NM_014229.1	NP_055044.1	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 11	349					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(13)|ovary(1)|skin(4)	35				OV - Ovarian serous cystadenocarcinoma(96;0.229)		CTTCGTGGCTGGGTTTGCCAT	0.597000													19	13					1.67942e-08	2.15925e-08	1	1	0
LILRB4	11006	broad.mit.edu	37	19	55175308	55175308	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:55175308G>T	ENST00000391736.1	+	5	482	c.167G>T	c.(166-168)cGg>cTg	p.R56L	LILRB4_ENST00000430952.2_Missense_Mutation_p.R56L|LILRB4_ENST00000270452.2_Missense_Mutation_p.R56L|LILRB4_ENST00000391734.3_Missense_Mutation_p.R56L|LILRB4_ENST00000391733.3_Missense_Mutation_p.R56L	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	56	Ig-like C2-type 1.					integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		CTGGAGGCTCGGGAGTACCGT	0.607000													25	151					9.86323e-18	1.38341e-17	1	1	0
BCKDHB	594	broad.mit.edu	37	6	80910684	80910684	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:80910684C>G	ENST00000320393.6	+	7	823	c.776C>G	c.(775-777)cCa>cGa	p.P259R	BCKDHB_ENST00000545529.1_3'UTR|BCKDHB_ENST00000356489.5_Missense_Mutation_p.P259R	NM_183050.2	NP_898871.1	P21953	ODBB_HUMAN	branched chain keto acid dehydrogenase E1, beta polypeptide	259					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|carboxy-lyase activity|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(10)|upper_aerodigestive_tract(1)	15		all_cancers(76;1.38e-05)|Acute lymphoblastic leukemia(125;1.15e-05)|all_hematologic(105;0.00118)|all_epithelial(107;0.0149)		BRCA - Breast invasive adenocarcinoma(397;0.0291)		TACAACATCCCACTGTCCCAG	0.423000													6	50					0	0	1	0	0
PICK1	9463	broad.mit.edu	37	22	38471101	38471101	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr22:38471101G>T	ENST00000404072.3	+	13	1557	c.1210G>T	c.(1210-1212)Ggg>Tgg	p.G404W	PICK1_ENST00000356976.3_Missense_Mutation_p.G404W	NM_001039583.1|NM_001039584.1	NP_001034672.1|NP_001034673.1	Q9NRD5	PICK1_HUMAN	protein interacting with PRKCA 1	404					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|monoamine transport|neuronal ion channel clustering|protein phosphorylation|receptor clustering|retrograde vesicle-mediated transport, Golgi to ER|synaptic transmission	cell junction|endocytic vesicle membrane|Golgi apparatus|perinuclear region of cytoplasm|presynaptic membrane	ATPase activity|metal ion binding|protein C-terminus binding|protein kinase C binding|receptor binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13	Melanoma(58;0.045)					AGGGGCTGCTGGGCCCTTGGA	0.682000													7	28					0.000274275	0.000311808	1	1	0
CROCCP3	114819	broad.mit.edu	37	1	16809824	16809824	+	RNA	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:16809824C>T	ENST00000263511.4	-	0	1961					NR_023386.1																						CTGCACCTCGCGCTGGGCGTC	0.662000													3	9					0	0	1	0	0
HLA-A	3105	broad.mit.edu	37	6	29910693	29910693	+	Missense_Mutation	SNP	A	A	G	rs41559716	by1000genomes	TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:29910693A>G	ENST00000396634.1	+	4	574	c.233A>G	c.(232-234)cAg>cGg	p.Q78R	HLA-A_ENST00000376806.5_Missense_Mutation_p.Q78R|HLA-A_ENST00000376809.5_Missense_Mutation_p.Q78R|HLA-A_ENST00000376802.2_Missense_Mutation_p.Q78R			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	78	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity	p.Q78R(2)		central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						TGGATAGAGCAGGAGGGGCCG	0.657000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			3	33					0	0	1	0	0
BTNL8	79908	broad.mit.edu	37	5	180338480	180338480	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr5:180338480G>T	ENST00000231229.4	+	3	773	c.539G>T	c.(538-540)aGg>aTg	p.R180M	BTNL8_ENST00000533815.2_5'UTR|BTNL8_ENST00000511704.1_Missense_Mutation_p.R64M|BTNL8_ENST00000505126.1_5'UTR|BTNL8_ENST00000508408.1_Missense_Mutation_p.R180M|BTNL8_ENST00000400707.3_Missense_Mutation_p.R55M|BTNL8_ENST00000340184.4_Missense_Mutation_p.R180M	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	180	Ig-like V-type 2.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACAGACTCCAGGACAAACAGA	0.552000													24	91					2.21704e-12	2.993e-12	1	1	0
SPDEF	25803	broad.mit.edu	37	6	34511922	34511922	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:34511922C>T	ENST00000374037.3	-	2	725	c.311G>A	c.(310-312)aGc>aAc	p.S104N	SPDEF_ENST00000544425.1_Missense_Mutation_p.S104N	NM_012391.2	NP_036523.1	O95238	SPDEF_HUMAN	SAM pointed domain containing ETS transcription factor	104					negative regulation of survival gene product expression|negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|skin(3)	15						CAAGTCCAGGCTGCCCGCTGG	0.682000													20	22					0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92471136	92471136	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr14:92471136G>T	ENST00000267622.4	-	11	3557	c.3184C>A	c.(3184-3186)Cag>Aag	p.Q1062K		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1062					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		TCTTTCTGCTGAATAATCTGA	0.343000			T	PDGFRB	AML								8	42					5.4927e-09	7.14713e-09	1	1	0
FBN3	84467	broad.mit.edu	37	19	8152717	8152717	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:8152717A>C	ENST00000600128.1	-	53	7025	c.6611T>G	c.(6610-6612)aTg>aGg	p.M2204R	FBN3_ENST00000270509.2_Missense_Mutation_p.M2204R|FBN3_ENST00000601739.1_Missense_Mutation_p.M2204R			Q75N90	FBN3_HUMAN	fibrillin 3	2204	EGF-like 35; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						acctcgaCACATGGCCCCATC	0.557000													29	11					0	0	1	0	0
TMEM38B	55151	broad.mit.edu	37	9	108467983	108467983	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr9:108467983C>A	ENST00000374688.1	+	2	766	c.56C>A	c.(55-57)cCa>cAa	p.P19Q	TMEM38B_ENST00000374692.3_Missense_Mutation_p.P73Q			Q9NVV0	TM38B_HUMAN	transmembrane protein 38B	73						integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	13						GCAGAGCCTCCATTGAAGTTT	0.418000													14	49					1.45105e-14	1.98372e-14	1	1	0
LOC645752	645752	broad.mit.edu	37	15	78211484	78211484	+	RNA	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr15:78211484C>T	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							TCCTCCTGCTCCTGGAGTCTC	0.587000													56	44					0	0	1	0	0
SNX25	83891	broad.mit.edu	37	4	186180144	186180144	+	Silent	SNP	G	G	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr4:186180144G>T	ENST00000504273.1	+	3	459	c.165G>T	c.(163-165)gtG>gtT	p.V55V	SNX25_ENST00000264694.8_Silent_p.V55V			Q9H3E2	SNX25_HUMAN	sorting nexin 25	55	PXA.				cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|breast(4)|endometrium(2)|kidney(4)|large_intestine(8)|lung(13)|ovary(2)|pancreas(2)|prostate(2)|urinary_tract(2)	40		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		ACGTGGATGTGGTTAAAGTTG	0.468000													3	31					1	1	1	1	0
RP11-483E23.2	0	broad.mit.edu	37	15	28599954	28599954	+	RNA	SNP	A	A	G	rs144345425	by1000genomes	TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr15:28599954A>G	ENST00000568624.1	-	0	452																											GGCTGTAGTAAAGTGCCATCT	0.478000													3	50					0	0	1	0	0
OR51A4	401666	broad.mit.edu	37	11	4967967	4967967	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr11:4967967A>G	ENST00000380373.2	-	1	389	c.364T>C	c.(364-366)Ttt>Ctt	p.F122L	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005329.1	NP_001005329.1	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A, member 4	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(15)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		AATCTATCAAATGACATGATC	0.438000													21	120					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20335488	20335488	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr16:20335488G>T	ENST00000302555.5	-	3	334	c.185C>A	c.(184-186)cCc>cAc	p.P62H	GP2_ENST00000381360.5_Intron|GP2_ENST00000381362.4_Missense_Mutation_p.P62H|GP2_ENST00000341642.5_Intron			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	62						anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						ATTCTGACAGGGGTCAAAACA	0.552000													11	35					1.61879e-10	2.13207e-10	1	1	0
FCGBP	8857	broad.mit.edu	37	19	40368357	40368357	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:40368357C>T	ENST00000221347.6	-	28	12998	c.12991G>A	c.(12991-12993)Gcc>Acc	p.A4331T		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4331						extracellular region	protein binding	p.A4331T(1)		NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCCTGGCAGGCGGCCACGTAG	0.647000													17	149					0	0	1	0	0
RPL32P3	132241	broad.mit.edu	37	3	129116038	129116038	+	RNA	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr3:129116038C>T	ENST00000514355.1	-	0	412																				lung(1)	1						GAGGCTTTCCCGCCCAGGGAC	0.567000													5	57					0	0	1	0	0
INHBB	3625	broad.mit.edu	37	2	121107068	121107068	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr2:121107068G>A	ENST00000295228.3	+	2	888	c.842G>A	c.(841-843)cGg>cAg	p.R281Q		NM_002193.2	NP_002184.2	P09529	INHBB_HUMAN	inhibin, beta B	281					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(4)|pancreas(2)|skin(2)	15		Prostate(154;0.122)				GTGCAGGCTCGGCTGGGCGAC	0.642000													26	58					0	0	1	0	0
HERC2P3	283755	broad.mit.edu	37	15	20588554	20588554	+	RNA	SNP	C	C	G	rs112526901	by1000genomes	TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr15:20588554C>G	ENST00000428453.1	-	0	4196																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						CCGTGGAAAGCGGTTGCAGAA	0.473000													4	77					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38993211	38993211	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:38993211C>T	ENST00000355481.4	+	48	7810	c.7679C>T	c.(7678-7680)cCg>cTg	p.P2560L	RYR1_ENST00000360985.3_Missense_Mutation_p.P2560L|RYR1_ENST00000359596.3_Missense_Mutation_p.P2560L	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	2560	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.P2560L(1)		NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCCGTGCTGCCGCTCATCACC	0.647000													18	11					0	0	1	0	0
NMBR	4829	broad.mit.edu	37	6	142396893	142396893	+	Silent	SNP	G	G	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:142396893G>T	ENST00000258042.1	-	3	1205	c.1065C>A	c.(1063-1065)ctC>ctA	p.L355L	NMBR_ENST00000480652.1_5'UTR	NM_002511.2	NP_002502.2	P28336	NMBR_HUMAN	neuromedin B receptor	355					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			breast(2)|central_nervous_system(3)|endometrium(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		CTGAAGAGCTGAGTAGGTAGC	0.463000													4	74					1.23904e-05	1.45453e-05	1	1	0
KCNH6	81033	broad.mit.edu	37	17	61607554	61607554	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr17:61607554C>T	ENST00000583023.1	+	3	421	c.410C>T	c.(409-411)gCc>gTc	p.A137V	KCNH6_ENST00000580652.1_Missense_Mutation_p.A137V|KCNH6_ENST00000314672.5_Missense_Mutation_p.A137V|KCNH6_ENST00000581784.1_Missense_Mutation_p.A137V|KCNH6_ENST00000456941.2_Missense_Mutation_p.A137V	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	137	PAC.				regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	CAGCTCCTGGCCAAGTGCAGC	0.627000													9	75					0	0	1	0	0
AKR7A3	22977	broad.mit.edu	37	1	19612766	19612766	+	Silent	SNP	G	G	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:19612766G>A	ENST00000361640.4	-	2	855	c.315C>T	c.(313-315)ccC>ccT	p.P105P		NM_012067.2	NP_036199.2	O95154	ARK73_HUMAN	aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)	105					cellular aldehyde metabolic process	cytosol	aldo-keto reductase (NADP) activity|electron carrier activity			NS(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)|ovary(1)|stomach(2)	13		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;1.78e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|GBM - Glioblastoma multiforme(114;0.00276)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GGTCCACTCGGGGACACTGCA	0.592000													28	45					0	0	1	0	0
MAPRE3	22924	broad.mit.edu	37	2	27247084	27247084	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr2:27247084C>T	ENST00000233121.2	+	4	586	c.388C>T	c.(388-390)Cgg>Tgg	p.R130W	MAPRE3_ENST00000402218.1_Missense_Mutation_p.R130W|MAPRE3_ENST00000405074.3_Missense_Mutation_p.R130W			Q9UPY8	MARE3_HUMAN	microtubule-associated protein, RP/EB family, member 3	130					cell division|mitosis|positive regulation of transcription, DNA-dependent	cytoplasm|cytoplasmic microtubule|microtubule|midbody|perinuclear region of cytoplasm	microtubule binding|protein binding|small GTPase regulator activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(3)|upper_aerodigestive_tract(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTGCTGGCGCGGCAGGGCCA	0.473000													22	26					0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92472033	92472033	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr14:92472033G>A	ENST00000267622.4	-	11	2660	c.2287C>T	c.(2287-2289)Cat>Tat	p.H763Y		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	763					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		TTAATTAAATGCTCATGTTCC	0.343000			T	PDGFRB	AML								28	119					0	0	1	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24259555	24259555	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr8:24259555G>T	ENST00000538205.1	+	13	1580	c.1033G>T	c.(1033-1035)Ggg>Tgg	p.G345W	RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|ADAMDEC1_ENST00000256412.4_Missense_Mutation_p.G424W|ADAMDEC1_ENST00000522298.1_Missense_Mutation_p.G345W	NM_001145271.1	NP_001138743.1	O15204	ADEC1_HUMAN	ADAM-like, decysin 1	424	Peptidase M12B.				integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		ACCAGTGTGTGGGAACCACCT	0.393000													3	26					0.184627	0.188111	1	1	0
TECPR2	9895	broad.mit.edu	37	14	102963969	102963969	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr14:102963969G>C	ENST00000359520.7	+	19	4220	c.3994G>C	c.(3994-3996)Gac>Cac	p.D1332H		NM_014844.3	NP_055659.2	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	1332							protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(21)|ovary(2)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	50						TCCAAACGGAGACCTCGCCCG	0.672000													6	18					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	160977080	160977080	+	Silent	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:160977080C>T	ENST00000447678.1	-	31	5070	c.4950G>A	c.(4948-4950)agG>agA	p.R1650R	LPA_ENST00000316300.5_Silent_p.R1650R	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	4158	Kringle 15.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TTTCTGGGGTCCTCTGATGCC	0.468000													18	39					0	0	1	0	0
PARP14	54625	broad.mit.edu	37	3	122432362	122432362	+	Silent	SNP	G	G	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr3:122432362G>A	ENST00000474629.2	+	10	3977	c.3711G>A	c.(3709-3711)acG>acA	p.T1237T		NM_017554.2	NP_060024.2	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1237	Macro 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			NS(2)|breast(5)|cervix(2)|endometrium(7)|kidney(5)|large_intestine(8)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	50				GBM - Glioblastoma multiforme(114;0.0531)		GAGATATCACGAAAGAAGAGG	0.383000													21	2					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92761033	92761033	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr7:92761033C>A	ENST00000318238.4	-	5	5468	c.4252G>T	c.(4252-4254)Gga>Tga	p.G1418*	SAMD9L_ENST00000411955.1_Nonsense_Mutation_p.G1418*|SAMD9L_ENST00000437805.1_Nonsense_Mutation_p.G1418*	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1418										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TGACTTAGTCCTACAAATTGC	0.398000													12	98					1.61879e-10	2.13207e-10	1	1	0
OR5AC2	81050	broad.mit.edu	37	3	97806804	97806804	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr3:97806804G>A	ENST00000358642.2	+	1	788	c.788G>A	c.(787-789)cGt>cAt	p.R263H		NM_054106.1	NP_473447.1	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC, member 2	263					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R263H(1)		endometrium(4)|large_intestine(3)|lung(13)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	28						ATGTATGTGCGTCCTGCATCT	0.428000													15	1					0	0	1	0	0
MAP1LC3C	440738	broad.mit.edu	37	1	242161837	242161837	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:242161837G>A	ENST00000357246.3	-	3	264	c.200C>T	c.(199-201)aCc>aTc	p.T67I		NM_001004343.2	NP_001004343.1	Q9BXW4	MLP3C_HUMAN	microtubule-associated protein 1 light chain 3 gamma	67					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule	protein binding			endometrium(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GAGGAACTGGGTCATGGTCAG	0.622000											OREG0014354	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	28					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100385659	100385659	+	RNA	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr7:100385659C>T	ENST00000542585.1	+	0	7273				ZAN_ENST00000538115.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000546213.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGGAAGGACGCAACAAGATGG	0.567000													8	44					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	160977073	160977073	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:160977073C>T	ENST00000447678.1	-	31	5077	c.4957G>A	c.(4957-4959)Gaa>Aaa	p.E1653K	LPA_ENST00000316300.5_Missense_Mutation_p.E1653K	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	4161	Kringle 15.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GGGTAGTTTTCTGGGGTCCTC	0.458000													18	38					0	0	1	0	0
AGO2	27161	broad.mit.edu	37	8	141595255	141595255	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr8:141595255C>T	ENST00000220592.5	-	2	290	c.178G>A	c.(178-180)Gat>Aat	p.D60N	AGO2_ENST00000517293.1_5'UTR|AGO2_ENST00000519980.1_Missense_Mutation_p.D60N	NM_012154.3	NP_036286.2			argonaute RISC catalytic component 2																		GGCTTGATATCCAATTCATAA	0.448000													7	64					0	0	1	0	0
ZBED2	79413	broad.mit.edu	37	3	111312564	111312564	+	Missense_Mutation	SNP	C	C	A	rs144259563	byFrequency	TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr3:111312564C>A	ENST00000317012.4	-	2	1493	c.485G>T	c.(484-486)aGg>aTg	p.R162M	CD96_ENST00000283285.5_Intron|CD96_ENST00000438817.2_Intron|CD96_ENST00000352690.4_Intron	NM_024508.4	NP_078784.2	Q9BTP6	ZBED2_HUMAN	zinc finger, BED-type containing 2	162							DNA binding|metal ion binding			large_intestine(3)|lung(1)|skin(2)	6						CCTTTCCCTCCTAAGCACCTC	0.607000													15	46					0.00498961	0.00533542	1	1	0
ACE2	59272	broad.mit.edu	37	X	15584429	15584429	+	Silent	SNP	T	T	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chrX:15584429T>A	ENST00000427411.1	-	17	2277	c.2061A>T	c.(2059-2061)gcA>gcT	p.A687A	ACE2_ENST00000252519.3_Silent_p.A687A	NM_021804.2	NP_068576.1	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2	687					angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	32	Hepatocellular(33;0.183)				Moexipril(DB00691)	CATTTTTAGGTGCAGTGACAA	0.398000													57	6					0	0	1	0	0
ERCC6	2074	broad.mit.edu	37	10	50686456	50686456	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr10:50686456G>A	ENST00000355832.5	-	11	2308	c.2230C>T	c.(2230-2232)Cgg>Tgg	p.R744W	ERCC6_ENST00000542458.1_Missense_Mutation_p.R114W	NM_000124.2	NP_000115.1	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6	744					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			breast(5)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						TTCATTCTCCGCAGTAGGTAT	0.383000								Direct reversal of damage;Nucleotide excision repair (NER)					4	119					0	0	1	0	0
CCDC87	55231	broad.mit.edu	37	11	66359169	66359169	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr11:66359169C>T	ENST00000333861.3	-	1	1385	c.1318G>A	c.(1318-1320)Gtg>Atg	p.V440M		NM_018219.2	NP_060689.2	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	440										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						GCCTGGACCACGACCTCATTT	0.552000													34	57					0	0	1	0	0
ANKMY2	57037	broad.mit.edu	37	7	16640497	16640497	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr7:16640497C>A	ENST00000306999.2	-	10	1458	c.1215G>T	c.(1213-1215)aaG>aaT	p.K405N		NM_020319.2	NP_064715.1	Q8IV38	ANKY2_HUMAN	ankyrin repeat and MYND domain containing 2	405						cilium	zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|urinary_tract(1)	23	Lung NSC(10;0.103)|all_lung(11;0.204)			UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		GATTGGAATCCTTTTGAGAGA	0.423000													3	39					1	1	1	1	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000429426.2_Silent_p.S165S|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								5	98					0	0	1	0	0
MAP3K7	6885	broad.mit.edu	37	6	91226241	91226241	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:91226241C>G	ENST00000369329.3	-	17	1961	c.1800G>C	c.(1798-1800)caG>caC	p.Q600H	MAP3K7_ENST00000369320.1_Missense_Mutation_p.Q254H|MAP3K7_ENST00000369325.3_3'UTR|MAP3K7_ENST00000369332.3_Missense_Mutation_p.Q573H|MAP3K7_ENST00000479630.1_5'UTR|MAP3K7_ENST00000369327.3_3'UTR	NM_145331.2	NP_663304.1	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	600					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	28		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		CTTGTCGTTTCTGCTGCTGAC	0.353000													22	46					0	0	1	0	0
PRDM13	59336	broad.mit.edu	37	6	100062529	100062529	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:100062529C>T	ENST00000369214.1	+	4	2309	c.2048C>T	c.(2047-2049)cCc>cTc	p.P683L	PRDM13_ENST00000369215.4_Missense_Mutation_p.P673L	NM_021620.3	NP_067633.2	Q9H4Q3	PRD13_HUMAN	PR domain containing 13	673					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(9)|prostate(1)	17		all_cancers(76;1.64e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0128)|Colorectal(196;0.069)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0598)		CCCGGCTATCCCCCGGAGCCT	0.716000													7	63					0	0	1	0	0
PRCC	5546	broad.mit.edu	37	1	156756826	156756826	+	Missense_Mutation	SNP	G	G	C	rs142005569		TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:156756826G>C	ENST00000271526.4	+	3	1215	c.943G>C	c.(943-945)Gat>Cat	p.D315H	PRCC_ENST00000353233.3_Missense_Mutation_p.D315H|PRCC_ENST00000491853.1_3'UTR	NM_005973.4	NP_005964.3	Q92733	PRCC_HUMAN	papillary renal cell carcinoma (translocation-associated)	315					cell cycle|mitotic cell cycle checkpoint	nucleus	protein binding		PRCC/TFE3(25)	breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(5)|upper_aerodigestive_tract(1)	15	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TTTCCAGGACGATGCAGCCAA	0.577000			T	TFE3	papillary renal								11	121					0	0	1	0	0
OR10J1	26476	broad.mit.edu	37	1	159410193	159410193	+	Silent	SNP	G	G	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:159410193G>T	ENST00000423932.3	+	1	682	c.645G>T	c.(643-645)ctG>ctT	p.L215L	RP11-550P17.5_ENST00000431862.1_RNA	NM_012351.2	NP_036483.2	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J, member 1	215					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					TCAGTGTGCTGGTGCTTGTTG	0.453000													9	57					1.12685e-05	1.35222e-05	1	1	0
MAP3K7	6885	broad.mit.edu	37	6	91226396	91226396	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:91226396C>T	ENST00000369329.3	-	17	1806	c.1645G>A	c.(1645-1647)Gaa>Aaa	p.E549K	MAP3K7_ENST00000369320.1_Missense_Mutation_p.E203K|MAP3K7_ENST00000369325.3_Missense_Mutation_p.R510K|MAP3K7_ENST00000369332.3_Missense_Mutation_p.E522K|MAP3K7_ENST00000479630.1_5'UTR|MAP3K7_ENST00000369327.3_Missense_Mutation_p.R483K	NM_145331.2	NP_663304.1	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	549					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	28		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		GCAACTAGTTCTTGCCTACAA	0.353000													12	19					0	0	1	0	0
OR1L6	392390	broad.mit.edu	37	9	125512476	125512476	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr9:125512476C>T	ENST00000373684.1	+	1	458	c.458C>T	c.(457-459)gCc>gTc	p.A153V	OR1L6_ENST00000304720.2_Missense_Mutation_p.A117V			Q8NGR2	OR1L6_HUMAN	olfactory receptor, family 1, subfamily L, member 6	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	12						TACCTGCTGGCCTCTATGGCC	0.502000													6	80					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10358370	10358370	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr17:10358370C>T	ENST00000255381.2	-	21	2433	c.2323G>A	c.(2323-2325)Gga>Aga	p.G775R	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	775	Actin-binding (By similarity).|Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TCTAGAGTTCCCAGCAGGCCA	0.403000													234	23					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53787666	53787666	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr3:53787666T>C	ENST00000288139.3	+	30	3921	c.3803T>C	c.(3802-3804)tTc>tCc	p.F1268S	CACNA1D_ENST00000350061.5_Missense_Mutation_p.F1248S|CACNA1D_ENST00000422281.2_Missense_Mutation_p.F1248S|CACNA1D_ENST00000540742.1_Missense_Mutation_p.F155S	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	1248					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	ACCGGGGTGTTCACCGTCGAG	0.478000													20	4					0	0	1	0	0
EP400NL	347918	broad.mit.edu	37	12	132589596	132589596	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr12:132589596C>T	ENST00000376625.4	+	1	1057	c.1031C>T	c.(1030-1032)cCc>cTc	p.P344L	EP400NL_ENST00000443539.2_Missense_Mutation_p.P212L|EP400NL_ENST00000361109.5_Missense_Mutation_p.P191L|EP400NL_ENST00000389560.2_Missense_Mutation_p.P275L|EP400NL_ENST00000392352.1_Missense_Mutation_p.P212L					EP400 N-terminal like											endometrium(1)|lung(1)|prostate(2)|urinary_tract(1)	5						GAGGAGATTCCCCCAGCCTCT	0.557000													2	2					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152286355	152286355	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:152286355G>C	ENST00000368799.1	-	3	1042	c.1007C>G	c.(1006-1008)cCc>cGc	p.P336R	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	336	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGGGACCTGGGGTGTCTGGA	0.562000									Ichthyosis				28	145					0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11233960	11233960	+	Silent	SNP	C	C	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:11233960C>A	ENST00000558518.1	+	15	2438	c.2251C>A	c.(2251-2253)Cgg>Agg	p.R751R	LDLR_ENST00000558013.1_Silent_p.R751R|LDLR_ENST00000545707.1_Silent_p.R573R|LDLR_ENST00000557933.1_Silent_p.R751R|LDLR_ENST00000535915.1_Silent_p.R710R|LDLR_ENST00000455727.2_Silent_p.R583R	NM_000527.4|NM_001195798.1	NP_000518.1|NP_001182727.1	P01130	LDLR_HUMAN	low density lipoprotein receptor	751	Clustered O-linked oligosaccharides.				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			breast(2)|endometrium(2)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	CGACACCTCCCGGCTGCCTGG	0.622000													10	61					1.76689e-08	2.24499e-08	1	1	0
ARID5A	10865	broad.mit.edu	37	2	97217113	97217113	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr2:97217113G>A	ENST00000454558.2	+	7	1821	c.644G>A	c.(643-645)gGg>gAg	p.G215E	ARID5A_ENST00000357485.3_Missense_Mutation_p.G283E			Q03989	ARI5A_HUMAN	AT rich interactive domain 5A (MRF1-like)	283					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|skin(1)|urinary_tract(2)	14						TGCCGCCATGGGGCAGAGCCC	0.652000													4	24					0	0	1	0	0
ZP2	7783	broad.mit.edu	37	16	21221024	21221024	+	Silent	SNP	C	C	T	rs150656642		TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr16:21221024C>T	ENST00000574002.1	-	5	740	c.258G>A	c.(256-258)ccG>ccA	p.P86P	ZP2_ENST00000574091.1_Silent_p.P86P|ZP2_ENST00000219593.4_Silent_p.P86P			Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 (sperm receptor)	86					binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(16)|ovary(1)|prostate(1)|stomach(1)	41				GBM - Glioblastoma multiforme(48;0.0573)		AAGTGCAGTTCGGCATGTCGA	0.498000													25	32					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45815342	45815342	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr21:45815342C>A	ENST00000397928.1	+	12	2285	c.1840C>A	c.(1840-1842)Cat>Aat	p.H614N	TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300482.5_Missense_Mutation_p.H614N|TRPM2_ENST00000397932.2_Missense_Mutation_p.H614N|TRPM2_ENST00000300481.9_Missense_Mutation_p.H594N	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	614						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						TTCCTCAGGCCATGTGACCTT	0.597000													22	107					3.83957e-06	4.76636e-06	1	1	0
FCRLA	84824	broad.mit.edu	37	1	161681733	161681733	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:161681733C>T	ENST00000540926.1	+	5	820	c.527C>T	c.(526-528)cCa>cTa	p.P176L	FCRLA_ENST00000540521.1_Missense_Mutation_p.P53L|FCRLA_ENST00000367949.2_Intron|FCRLA_ENST00000367950.1_Intron|FCRLA_ENST00000236938.6_Missense_Mutation_p.P187L|FCRLA_ENST00000367953.3_Missense_Mutation_p.P176L|FCRLA_ENST00000367957.2_Missense_Mutation_p.P47L|FCRLA_ENST00000367959.2_Missense_Mutation_p.P193L|FCRLA_ENST00000350710.3_Intron|FCRLA_ENST00000349527.4_Intron|FCRLA_ENST00000309691.6_Missense_Mutation_p.P81L|FCRLA_ENST00000294796.4_Missense_Mutation_p.P36L|FCRLA_ENST00000470841.1_3'UTR|FCRLA_ENST00000546024.1_Missense_Mutation_p.P98L			Q7L513	FCRLA_HUMAN	Fc receptor-like A	170	Ig-like C2-type 2.				cell differentiation	cytoplasm|extracellular region				breast(1)|kidney(12)|large_intestine(4)|lung(13)|prostate(1)|skin(2)|stomach(1)	34	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			GAACTGTTTCCAGCGCCAATT	0.517000													116	100					0	0	1	0	0
FAM161A	84140	broad.mit.edu	37	2	62054287	62054287	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr2:62054287T>C	ENST00000404929.1	-	6	1969	c.1958A>G	c.(1957-1959)gAg>gGg	p.E653G	FAM161A_ENST00000405894.3_Missense_Mutation_p.E597G	NM_001201543.1	NP_001188472.1	Q3B820	F161A_HUMAN	family with sequence similarity 161, member A	597	Glu-rich.				response to stimulus|visual perception	centrosome				breast(1)|endometrium(5)|large_intestine(8)|lung(4)|ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						GTTGAAGTACTCAAGTACTTT	0.348000													15	36					0	0	1	0	0
CCDC63	160762	broad.mit.edu	37	12	111336859	111336859	+	Silent	SNP	C	C	T	rs115748204	by1000genomes	TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr12:111336859C>T	ENST00000308208.5	+	10	1514	c.1272C>T	c.(1270-1272)gaC>gaT	p.D424D	CCDC63_ENST00000545036.1_Silent_p.D384D|CCDC63_ENST00000552694.1_Silent_p.D345D	NM_152591.1	NP_689804.1	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	424										NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(1)	39						TAAACTGTGACGCCACCAAGA	0.498000													11	15					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37271732	37271732	+	Nonsense_Mutation	SNP	T	T	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:37271732T>A	ENST00000373091.3	-	14	2303	c.2287A>T	c.(2287-2289)Aag>Tag	p.K763*	GRIK3_ENST00000373093.4_Nonsense_Mutation_p.K763*	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	763					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CCGTAGCCCTTGGAGTCAATG	0.672000													8	46					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8526635	8526635	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr9:8526635G>T	ENST00000381196.4	-	14	1103	c.560C>A	c.(559-561)cCa>cAa	p.P187Q	PTPRD_ENST00000540109.1_Missense_Mutation_p.P187Q|PTPRD_ENST00000360074.4_Intron|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000358503.5_Intron|PTPRD_ENST00000486161.1_Missense_Mutation_p.P187Q|PTPRD_ENST00000356435.5_Missense_Mutation_p.P187Q|PTPRD_ENST00000355233.5_Missense_Mutation_p.P187Q|PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000397611.3_Missense_Mutation_p.P184Q|PTPRD_ENST00000397617.3_Intron	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	187	Ig-like C2-type 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ACCTCTTATTGGTGTACCACC	0.398000										TSP Lung(15;0.13)			8	37					1.12685e-05	1.35222e-05	1	1	0
GDF10	2662	broad.mit.edu	37	10	48426603	48426603	+	Silent	SNP	G	G	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr10:48426603G>T	ENST00000224605.2	-	3	1669	c.1404C>A	c.(1402-1404)ccC>ccA	p.P468P		NM_004962.3	NP_004953.1	P55107	BMP3B_HUMAN	growth differentiation factor 10	468					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(20)|skin(1)	31						CGGACATGTTGGGGTACACCT	0.587000											OREG0020165	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	96					0.00116845	0.00128767	1	1	0
SLC9C2	284525	broad.mit.edu	37	1	173551109	173551109	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:173551109C>A	ENST00000367714.3	-	7	1101	c.679G>T	c.(679-681)Gga>Tga	p.G227*	SLC9C2_ENST00000536496.1_Nonsense_Mutation_p.G125*|RP3-436N22.3_ENST00000431459.1_RNA	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	227					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										ATTATGCTTCCCAAAATGTCA	0.299000													5	12					0.000602214	0.000677491	1	1	0
ABL2	27	broad.mit.edu	37	1	179078493	179078493	+	Frame_Shift_Del	DEL	C	C	-			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:179078493delC	ENST00000502732.1	-	12	2112	c.1909delG	c.(1909-1911)aafs	p.E637fs	ABL2_ENST00000504405.1_Frame_Shift_Del_p.E601fs|ABL2_ENST00000507173.1_Frame_Shift_Del_p.E616fs|ABL2_ENST00000408940.3_Frame_Shift_Del_p.E601fs|ABL2_ENST00000512653.1_Frame_Shift_Del_p.E622fs|ABL2_ENST00000367623.4_Frame_Shift_Del_p.E616fs|ABL2_ENST00000344730.3_Frame_Shift_Del_p.E622fs|ABL2_ENST00000511413.1_Frame_Shift_Del_p.E637fs	NM_001168236.1|NM_001168237.1|NM_001168238.1|NM_007314.3	NP_001161708.1|NP_001161709.1|NP_001161710.1|NP_009298.1	P42684	ABL2_HUMAN	c-abl oncogene 2, non-receptor tyrosine kinase	637					axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(8)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	65					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	TTGGCATCTTCCAAGAGGCTG	0.542			T	ETV6	AML								65	53	---	---	---	---					
LOC101929950	101929950	broad.mit.edu	37	17	36412964	36412964	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr17:36412964delA	ENST00000312412.4	-	1	195	c.196delT	c.(196-198)gcfs	p.C66fs																	kidney(1)|lung(3)	4						GGCTTGAGGCAAAGGCTGCAG	0.706													2	4	---	---	---	---					
FHOD3	80206	broad.mit.edu	37	18	34261459	34261460	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr18:34261459_34261460delAG	ENST00000257209.4	+	12	1493_1494	c.1371_1372delAG	c.(1369-1374)gcagfs	p.AE457fs	FHOD3_ENST00000359247.4_Frame_Shift_Del_p.AE457fs|FHOD3_ENST00000590592.1_Frame_Shift_Del_p.AE632fs|FHOD3_ENST00000591635.1_Intron|FHOD3_ENST00000445677.1_Frame_Shift_Del_p.AE419fs	NM_025135.2	NP_079411.2	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	457					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|liver(2)|lung(29)|ovary(3)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	90		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				CACTGGCAGCAGAGAGAGAGAG	0.460													8	62	---	---	---	---					
SEL1L2	80343	broad.mit.edu	37	20	13830156	13830156	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr20:13830156delA	ENST00000284951.5	-	20	2116	c.2042delT	c.(2041-2043)tgfs	p.L683fs	SEL1L2_ENST00000378072.5_Frame_Shift_Del_p.L570fs|SEL1L2_ENST00000486903.1_5'UTR			Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 (C. elegans)	683						integral to membrane	binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	51						TCTAAGCAACAAAATCAGCCC	0.473													29	22	---	---	---	---