Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OPTC	26254	broad.mit.edu	37	1	203465179	203465179	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:203465179G>A	ENST00000367222.2	+	2	162	c.46G>A	c.(46-48)Gag>Aag	p.E16K		NM_014359.3	NP_055174.1	Q9UBM4	OPT_HUMAN	opticin	16						proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			breast(1)|cervix(1)|kidney(5)|large_intestine(3)|lung(8)|pancreas(1)|stomach(1)	20			BRCA - Breast invasive adenocarcinoma(75;0.109)			GGTGCTGCAGGAGACAGGGAC	0.582000													16	21					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20944735	20944735	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr16:20944735G>A	ENST00000261383.3	-	62	12091	c.12092C>T	c.(12091-12093)aCg>aTg	p.T4031M	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	4031					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		AATCTGCATCGTTTTCCTGTC	0.507000													40	88					0	0	1	0	0
DRD1	1812	broad.mit.edu	37	5	174869119	174869119	+	Silent	SNP	G	G	A	rs141925440		TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr5:174869119G>A	ENST00000393752.2	-	2	1976	c.984C>T	c.(982-984)ccC>ccT	p.P328P		NM_000794.3	NP_000785.1	P21728	DRD1_HUMAN	dopamine receptor D1	328					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|adult walking behavior|cerebral cortex GABAergic interneuron migration|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|mating behavior|positive regulation of cAMP biosynthetic process|positive regulation of cell migration|positive regulation of potassium ion transport|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of synaptic transmission, glutamatergic|prepulse inhibition|response to drug|synapse assembly|visual learning	endoplasmic reticulum membrane|membrane fraction	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23	all_cancers(89;0.00895)|Renal(175;0.000159)|Lung NSC(126;0.00625)|all_lung(126;0.0104)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)		Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Carphenazine(DB01038)|Chlorprothixene(DB01239)|Clozapine(DB00363)|Cocaine(DB00907)|Dopamine(DB00988)|Fenoldopam(DB00800)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Methylergonovine(DB00353)|Minaprine(DB00805)|Olanzapine(DB00334)|Pegademase bovine(DB00061)|Pergolide(DB01186)|Perphenazine(DB00850)|Prochlorperazine(DB00433)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Triflupromazine(DB00508)|Zuclopenthixol(DB01624)	CATAAATGATGGGGTTCAAGG	0.483000													30	44					0	0	1	0	0
PLCZ1	89869	broad.mit.edu	37	12	18837109	18837109	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr12:18837109C>T	ENST00000266505.7	-	14	1959	c.1696G>A	c.(1696-1698)Gaa>Aaa	p.E566K	PLCZ1_ENST00000541695.1_3'UTR|PLCZ1_ENST00000435379.1_Missense_Mutation_p.E371K|PLCZ1_ENST00000447925.2_Missense_Mutation_p.E564K|PLCZ1_ENST00000539875.1_Missense_Mutation_p.E373K|PLCZ1_ENST00000538330.1_Missense_Mutation_p.E348K|PLCZ1_ENST00000534932.1_Missense_Mutation_p.E47K			Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	566	C2.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					CCAAGAAATTCATTTCCTGCT	0.333000													23	74					0	0	1	0	0
OR6C68	403284	broad.mit.edu	37	12	55886345	55886345	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr12:55886345C>A	ENST00000379662.1	+	1	199	c.199C>A	c.(199-201)Caa>Aaa	p.Q67K	RP11-110A12.2_ENST00000554049.1_RNA|RP11-110A12.2_ENST00000556750.1_RNA|OR6C68_ENST00000548615.1_Missense_Mutation_p.Q62K|RP11-110A12.2_ENST00000555138.1_RNA			A6NDL8	O6C68_HUMAN	olfactory receptor, family 6, subfamily C, member 68	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	15						TTTTTTTCTCCAAAATTTATC	0.363000													50	125					4.86159e-25	4.9508e-25	1	1	0
HECW1	23072	broad.mit.edu	37	7	43519247	43519247	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr7:43519247C>T	ENST00000395891.1	+	17	3743	c.3138C>T	c.(3136-3138)ttC>ttT	p.F1046F	HECW1_ENST00000453890.1_Silent_p.F1012F	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	1046	WW 2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						CTACCACTTTCATTGACCCCC	0.507000													47	164					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179433209	179433209	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr2:179433209C>T	ENST00000589042.1	-	326	77874	c.77650G>A	c.(77650-77652)Gaa>Aaa	p.E25884K	TTN_ENST00000359218.5_Missense_Mutation_p.E16944K|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E24243K|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E23316K|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E17011K|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E16819K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	24243	Fibronectin type-III 88.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.E23314K(1)|p.E17011K(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTACAATTTCGATGGATGCT	0.388000													23	67					0	0	1	0	0
SAFB2	9667	broad.mit.edu	37	19	5592769	5592769	+	Silent	SNP	G	G	A	rs138974953	byFrequency	TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr19:5592769G>A	ENST00000252542.4	-	16	2601	c.2337C>T	c.(2335-2337)caC>caT	p.H779H		NM_014649.2	NP_055464.1	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	779	Arg-rich.|Interacts with SAFB1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		TGTCGATGGCGTGGTCCTGGT	0.602000													3	19					0	0	1	0	0
CYP4B1	1580	broad.mit.edu	37	1	47283859	47283859	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:47283859C>T	ENST00000271153.4	+	11	1362	c.1326C>T	c.(1324-1326)gcC>gcT	p.A442A	CYP4B1_ENST00000371919.4_Silent_p.A428A|CYP4B1_ENST00000452782.2_Silent_p.A280A|CYP4B1_ENST00000371923.4_Silent_p.A443A			P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B, polypeptide 1	442					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	36	Acute lymphoblastic leukemia(166;0.155)					ATCCCTTTGCCTTTATGCCCT	0.562000													30	74					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11576105	11576105	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:11576105C>T	ENST00000294484.6	+	6	1774	c.1636C>T	c.(1636-1638)Cac>Tac	p.H546Y	PTCHD2_ENST00000389575.3_Missense_Mutation_p.H546Y	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	546	SSD.				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CCAGGCCACCCACCTGGAAGA	0.592000													10	31					0	0	1	0	0
RCAN2	10231	broad.mit.edu	37	6	46216612	46216612	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr6:46216612G>A	ENST00000371374.1	-	3	438	c.247C>T	c.(247-249)Cgg>Tgg	p.R83W	RCAN2_ENST00000330430.6_Missense_Mutation_p.R37W|RCAN2_ENST00000405162.1_Missense_Mutation_p.R83W|RCAN2_ENST00000306764.7_Missense_Mutation_p.R83W	NM_001251974.1	NP_001238903.1	Q14206	RCAN2_HUMAN	regulator of calcineurin 2	37					calcium-mediated signaling|central nervous system development		nucleotide binding|protein phosphatase 2B binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	8						TCATAAGTCCGAAACAGTCCC	0.403000													21	48					0	0	1	0	0
MBD5	55777	broad.mit.edu	37	2	149247692	149247692	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr2:149247692C>T	ENST00000407073.1	+	12	4789	c.3792C>T	c.(3790-3792)ttC>ttT	p.F1264F	MBD5_ENST00000404807.1_Silent_p.F1497F	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1264						chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		AGGAAAATTTCAGGTATAATA	0.408000													29	73					0	0	1	0	0
CHIAP2	149620	broad.mit.edu	37	1	111824209	111824209	+	RNA	SNP	G	G	A	rs6537690	by1000genomes	TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:111824209G>A	ENST00000369743.4	+	0	93					NR_003928.1																						TTCACCAACTGGGCCCAGAAC	0.517000													3	24					0	0	1	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68810234	68810234	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr4:68810234C>T	ENST00000334830.7	-	3	1001	c.255G>A	c.(253-255)gtG>gtA	p.V85V	TMPRSS11A_ENST00000396188.2_Intron|RP11-453E17.1_ENST00000500538.2_RNA|TMPRSS11A_ENST00000508048.1_Intron			Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A	85	SEA.				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|cervix(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	29						TTACCTGACTCACCAAATTTT	0.348000													43	93					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													4	39					0	0	1	0	0
OR3A2	4995	broad.mit.edu	37	17	3181519	3181519	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr17:3181519G>A	ENST00000408891.2	-	1	749	c.711C>T	c.(709-711)atC>atT	p.I237I		NM_002551.3	NP_002542.3	P47893	OR3A2_HUMAN	olfactory receptor, family 3, subfamily A, member 2	237					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						CCACTGAACGGATTCGTAGAA	0.522000													31	46					0	0	1	0	0
BOLA1	51027	broad.mit.edu	37	1	149871725	149871725	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:149871725C>T	ENST00000369153.2	+	3	777	c.113C>T	c.(112-114)aCg>aTg	p.T38M	BOLA1_ENST00000369150.1_Missense_Mutation_p.T38M|BOLA1_ENST00000369152.5_Missense_Mutation_p.T38M|BOLA1_ENST00000476344.1_3'UTR			Q9Y3E2	BOLA1_HUMAN	bolA family member 1	38						extracellular region	protein binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	10	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			GCCATTCGCACGAAGTTGGAG	0.687000													10	45					0	0	1	0	0
PRPF8	10594	broad.mit.edu	37	17	1584067	1584067	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr17:1584067A>T	ENST00000572621.1	-	7	1316	c.1051T>A	c.(1051-1053)Tac>Aac	p.Y351N	PRPF8_ENST00000304992.6_Missense_Mutation_p.Y351N			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	351						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		GGGTCAAAGTAGAAAGCTGGC	0.473000													37	99					0	0	1	0	0
OR2C3	81472	broad.mit.edu	37	1	247695394	247695394	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:247695394C>T	ENST00000366487.3	-	2	781	c.420G>A	c.(418-420)caG>caA	p.Q140Q	GCSAML_ENST00000527541.1_Intron|GCSAML_ENST00000366490.3_Intron|GCSAML_ENST00000366489.1_Intron|GCSAML_ENST00000531662.1_Intron|GCSAML_ENST00000527084.1_Intron|GCSAML_ENST00000463359.1_Intron|GCSAML_ENST00000366491.2_Intron	NM_198074.4	NP_932340.3	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C, member 3	140					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|large_intestine(2)|lung(31)|ovary(1)|prostate(1)|skin(2)	43	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			CAAGGCAAAGCTGTGGATGCA	0.597000													20	24					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186545428	186545428	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr4:186545428G>A	ENST00000431808.1	-	14	1706	c.1143C>T	c.(1141-1143)tcC>tcT	p.S381S	SORBS2_ENST00000284776.7_Silent_p.S381S|SORBS2_ENST00000418609.1_Silent_p.S285S|SORBS2_ENST00000448662.2_Intron|SORBS2_ENST00000498125.1_Intron|SORBS2_ENST00000319471.9_Intron|SORBS2_ENST00000437304.2_Intron|SORBS2_ENST00000449407.2_Intron|SORBS2_ENST00000393528.3_Intron|SORBS2_ENST00000355634.5_Silent_p.S481S			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	381						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		CACAGCTCCGGGATTTGATTT	0.532000													20	60					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152554150	152554150	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr2:152554150C>T	ENST00000397345.3	-	14	1367	c.1165G>A	c.(1165-1167)Gaa>Aaa	p.E389K	NEB_ENST00000409198.1_Missense_Mutation_p.E389K|NEB_ENST00000427231.2_Missense_Mutation_p.E389K|NEB_ENST00000172853.10_Missense_Mutation_p.E389K|NEB_ENST00000603639.1_Missense_Mutation_p.E389K|NEB_ENST00000604864.1_Missense_Mutation_p.E389K	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	389					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCATAGTTTTCCTTGTATAGT	0.348000													14	51					0	0	1	0	0
TPR	7175	broad.mit.edu	37	1	186307184	186307184	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:186307184A>C	ENST00000367478.3	-	31	4639	c.4343T>G	c.(4342-4344)cTt>cGt	p.L1448R		NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein	1448					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TTGTGCTTTAAGTTCTTCATA	0.269000			T	NTRK1	papillary thyroid								14	75					0	0	1	0	0
VNN3	55350	broad.mit.edu	37	6	133045892	133045892	+	Silent	SNP	A	A	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr6:133045892A>T	ENST00000207771.3	-	6	1125	c.1053T>A	c.(1051-1053)ctT>ctA	p.L351L	VNN3_ENST00000417437.2_3'UTR|VNN3_ENST00000427187.2_3'UTR|VNN3_ENST00000414302.2_3'UTR|VNN3_ENST00000425515.2_3'UTR|VNN3_ENST00000392393.3_3'UTR|VNN3_ENST00000509351.1_3'UTR|VNN3_ENST00000367927.5_3'UTR|VNN3_ENST00000423615.2_3'UTR|VNN3_ENST00000519686.2_3'UTR|VNN3_ENST00000275223.3_3'UTR					vanin 3											cervix(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)|stomach(1)	8	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00242)|GBM - Glioblastoma multiforme(226;0.0168)		TATTTCTCTTAAGCTTGGTGA	0.418000													15	27					0	0	1	0	0
FLOT2	2319	broad.mit.edu	37	17	27210166	27210166	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr17:27210166G>A	ENST00000394906.2	-	6	548	c.471C>T	c.(469-471)gtC>gtT	p.V157V	FLOT2_ENST00000394908.4_Silent_p.V102V|FLOT2_ENST00000585169.1_Silent_p.V102V|FLOT2_ENST00000577789.1_5'UTR			Q14254	FLOT2_HUMAN	flotillin 2	102					cell adhesion|epidermis development	cell surface|endocytic vesicle|endosome|membrane fraction				endometrium(3)|lung(6)|prostate(1)|urinary_tract(1)	11	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;3.26e-06)|all cancers(11;1.76e-05)|BRCA - Breast invasive adenocarcinoma(11;0.00015)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)			TCTGCAGGACGACGTTTTTGA	0.572000													37	84					0	0	1	0	0
EMR1	2015	broad.mit.edu	37	19	6908743	6908743	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr19:6908743A>G	ENST00000312053.4	+	10	1119	c.1082A>G	c.(1081-1083)gAc>gGc	p.D361G	EMR1_ENST00000450315.3_Missense_Mutation_p.D184G|EMR1_ENST00000381404.4_Missense_Mutation_p.D309G|EMR1_ENST00000381407.5_Missense_Mutation_p.D220G|EMR1_ENST00000250572.8_Missense_Mutation_p.D361G	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	361	Ser/Thr-rich.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					AGCGTTCTGGACAAAGTGTGT	0.388000													42	60					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18956224	18956224	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr11:18956224G>A	ENST00000302797.3	-	1	332	c.108C>T	c.(106-108)atC>atT	p.I36I	MRGPRX1_ENST00000526914.1_5'UTR	NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	36			I -> V (in dbSNP:rs11024885).		acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						CAAGGGAAACGATGCACGTCA	0.557000													53	173					0	0	1	0	0
ZNF521	25925	broad.mit.edu	37	18	22806092	22806092	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr18:22806092T>C	ENST00000361524.3	-	4	1938	c.1790A>G	c.(1789-1791)aAt>aGt	p.N597S	ZNF521_ENST00000538137.2_Missense_Mutation_p.N597S|ZNF521_ENST00000584787.1_Missense_Mutation_p.N377S	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	597					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TTTCTTCCCATTGTGGATATA	0.443000			T	PAX5	ALL								27	46					0	0	1	0	0
AP3B1	8546	broad.mit.edu	37	5	77458735	77458735	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr5:77458735G>A	ENST00000255194.6	-	13	1446	c.1271C>T	c.(1270-1272)aCt>aTt	p.T424I	AP3B1_ENST00000519295.1_Missense_Mutation_p.T375I	NM_001271769.1	NP_001258698.1	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1 subunit	424					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(12)|lung(12)|prostate(1)|skin(2)|urinary_tract(1)	39		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		AGTCTGAATAGTGGCTGCTGC	0.408000									Hermansky-Pudlak syndrome				12	110					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14511989	14511989	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr18:14511989A>G	ENST00000358970.5	-	11	1536	c.1537T>C	c.(1537-1539)Tct>Cct	p.S513P		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	513										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						TGACTAAGAGAAAGCTAAGTA	0.318000													11	36					0	0	1	0	0
OR10A3	26496	broad.mit.edu	37	11	7960730	7960730	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr11:7960730A>C	ENST00000360759.3	-	1	411	c.338T>G	c.(337-339)tTt>tGt	p.F113C		NM_001003745.1	NP_001003745.1	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A, member 3	113					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)	21				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TCCCAGGAGAAAACATTCAGT	0.408000													59	88					0	0	1	0	0
SDK2	54549	broad.mit.edu	37	17	71335029	71335029	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr17:71335029G>A	ENST00000392650.3	-	45	6216	c.6216C>T	c.(6214-6216)tcC>tcT	p.S2072S	SDK2_ENST00000388726.3_Silent_p.S2053S|SDK2_ENST00000410094.1_5'UTR	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	2072					cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						GGTTGACAAAGGAGTGGGCCT	0.592000													18	38					0	0	1	0	0
TNFRSF21	27242	broad.mit.edu	37	6	47200581	47200581	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr6:47200581C>T	ENST00000296861.2	-	6	2281	c.1888G>A	c.(1888-1890)Gaa>Aaa	p.E630K		NM_014452.3	NP_055267.1	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily, member 21	630					cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity	p.E630K(1)		breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(7)|pancreas(1)|skin(2)	21			Lung(136;0.189)			CCAATAATTTCGAATAGCCGG	0.493000													58	129					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185798382	185798382	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr2:185798382C>T	ENST00000302277.6	+	3	902	c.308C>T	c.(307-309)tCc>tTc	p.S103F		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	103						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						GCATCTAAATCCAGGAAAGAT	0.373000													34	47					0	0	1	0	0
BHMT	635	broad.mit.edu	37	5	78422045	78422045	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr5:78422045C>T	ENST00000274353.5	+	6	909	c.802C>T	c.(802-804)Cca>Tca	p.P268S	DMGDH_ENST00000520388.1_Intron|BHMT_ENST00000524080.1_Missense_Mutation_p.P115S	NM_001713.2	NP_001704.2	Q93088	BHMT1_HUMAN	betaine--homocysteine S-methyltransferase	268	Hcy-binding.				protein methylation|regulation of homocysteine metabolic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding	p.P268T(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)	29		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.88e-45)|Epithelial(54;8.07e-41)|all cancers(79;3.51e-36)	L-Methionine(DB00134)	CCCAGAATTCCCATTTGGTAA	0.433000													17	42					0	0	1	0	0
PARP15	165631	broad.mit.edu	37	3	122334616	122334616	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr3:122334616C>T	ENST00000310366.4	+	1	155	c.60C>T	c.(58-60)ttC>ttT	p.F20F	PARP15_ENST00000465304.1_Intron|PARP15_ENST00000493645.1_Silent_p.F20F|PARP15_ENST00000464300.2_Intron|PARP15_ENST00000483793.1_Intron	NM_152615.1	NP_689828.1	Q460N3	PAR15_HUMAN	poly (ADP-ribose) polymerase family, member 15	232					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	NAD+ ADP-ribosyltransferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(114;0.0531)		GTAACTGTTTCTATTTCCAGG	0.353000													22	55					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	406941	406941	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr9:406941C>T	ENST00000432829.2	+	28	3514	c.3198C>T	c.(3196-3198)tcC>tcT	p.S1066S	DOCK8_ENST00000469391.1_Silent_p.S1034S|DOCK8_ENST00000453981.1_Silent_p.S1134S|DOCK8_ENST00000382329.1_Silent_p.S601S	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1134					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		ACTCAAGCTCCTGCTCCAGCT	0.532000													44	77					0	0	1	0	0
CROCC	9696	broad.mit.edu	37	1	17279836	17279836	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:17279836C>T	ENST00000375541.5	+	21	3115	c.3046C>T	c.(3046-3048)Ctg>Ttg	p.L1016L	CROCC_ENST00000467938.1_3'UTR	NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	1016					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GCGGGCCCAGCTGCAGAGTCA	0.687000													4	10					0	0	1	0	0
ZNF215	7762	broad.mit.edu	37	11	6977370	6977370	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr11:6977370T>C	ENST00000278319.5	+	7	1750	c.1162T>C	c.(1162-1164)Ttc>Ctc	p.F388L	ZNF215_ENST00000529903.1_Intron|ZNF215_ENST00000414517.2_Missense_Mutation_p.F388L	NM_013250.2	NP_037382.2	Q9UL58	ZN215_HUMAN	zinc finger protein 215	388					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(2)|skin(4)	32				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		TGGGAAAGCCTTCTGCCGAAG	0.383000													31	34					0	0	1	0	0
SND1	27044	broad.mit.edu	37	7	127484404	127484404	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr7:127484404C>T	ENST00000354725.3	+	12	1464	c.1270C>T	c.(1270-1272)Cca>Tca	p.P424S		NM_014390.2	NP_055205.2	Q7KZF4	SND1_HUMAN	staphylococcal nuclease and tudor domain containing 1	424	TNase-like 3.				gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	41						CTACATTAGACCAGCCAGCCC	0.522000													19	28					0	0	1	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140724441	140724441	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr5:140724441C>T	ENST00000253812.6	+	1	841	c.841C>T	c.(841-843)Cta>Tta	p.L281L	PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCTTATATTCTAGATAAAAT	0.448000													16	48					0	0	1	0	0
FAM193B	54540	broad.mit.edu	37	5	176965996	176965996	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr5:176965996G>A	ENST00000443375.2	-	3	1582	c.24C>T	c.(22-24)ctC>ctT	p.L8L	FAM193B_ENST00000514747.1_Silent_p.L121L|FAM193B_ENST00000329540.5_5'UTR|FAM193B_ENST00000508298.1_Intron			Q6IPW0	Q6IPW0_HUMAN	family with sequence similarity 193, member B	0										kidney(1)|large_intestine(3)	4						TCTCGCCTAGGAGATTCTTGA	0.552000													29	72					0	0	1	0	0
LANCL1	10314	broad.mit.edu	37	2	211300994	211300994	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr2:211300994G>A	ENST00000443314.1	-	7	1338	c.996C>T	c.(994-996)ttC>ttT	p.F332F	AC007970.1_ENST00000420418.1_RNA|LANCL1_ENST00000441020.3_Silent_p.F332F|LANCL1_ENST00000233714.4_Silent_p.F332F|LANCL1_ENST00000450366.2_Silent_p.F332F|AC007970.1_ENST00000433296.1_RNA|LANCL1_ENST00000431941.2_Silent_p.F332F			O43813	LANC1_HUMAN	LanC lantibiotic synthetase component C-like 1 (bacterial)	332						cytoplasm|integral to plasma membrane|microtubule cytoskeleton|nucleus	catalytic activity|G-protein coupled receptor activity|glutathione binding|low-density lipoprotein particle receptor binding|SH3 domain binding|zinc ion binding			breast(1)|large_intestine(5)|liver(1)|lung(4)|prostate(1)	12				Epithelial(149;0.00562)|Lung(261;0.0468)|LUSC - Lung squamous cell carcinoma(261;0.0495)|all cancers(144;0.0569)		AGAGTGTCAGGAAGGCATAGG	0.507000													33	85					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871160	51871160	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr20:51871160C>T	ENST00000371497.5	+	2	2050	c.1163C>T	c.(1162-1164)tCc>tTc	p.S388F	TSHZ2_ENST00000329613.6_Missense_Mutation_p.S385F|TSHZ2_ENST00000603338.2_Missense_Mutation_p.S385F	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	388					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			TGTGGGAGCTCCCATGACACC	0.532000													36	74					0	0	1	0	0
SEMA4A	64218	broad.mit.edu	37	1	156146313	156146313	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:156146313C>T	ENST00000368285.3	+	15	2078	c.1811C>T	c.(1810-1812)aCt>aTt	p.T604I	SEMA4A_ENST00000355014.2_Missense_Mutation_p.T604I|SEMA4A_ENST00000368282.1_Missense_Mutation_p.T604I|SEMA4A_ENST00000368286.2_Missense_Mutation_p.T472I|SEMA4A_ENST00000368284.1_Missense_Mutation_p.T472I	NM_001193300.1|NM_022367.3	NP_001180229.1|NP_071762.2	Q9H3S1	SEM4A_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	604	Ig-like C2-type.				axon guidance	integral to membrane|plasma membrane	receptor activity			breast(1)|ovary(2)|skin(2)	5	Hepatocellular(266;0.158)					GCCTCTTCCACTGTCTACAAT	0.562000													15	66					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62299059	62299059	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr11:62299059G>A	ENST00000378024.4	-	5	3104	c.2830C>T	c.(2830-2832)Ccc>Tcc	p.P944S	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	944					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				GAGATCTTGGGGGCCTTGATA	0.473000													110	152					0	0	1	0	0
HNF4A	3172	broad.mit.edu	37	20	43052726	43052726	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr20:43052726G>A	ENST00000316099.3	+	8	1050	c.961G>A	c.(961-963)Gac>Aac	p.D321N	HNF4A_ENST00000415691.1_Missense_Mutation_p.D321N|HNF4A_ENST00000457232.1_Missense_Mutation_p.D299N|HNF4A_ENST00000443598.2_Missense_Mutation_p.D321N	NM_000457.4|NM_001258355.1	NP_000448.3|NP_001245284.1	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4, alpha	321					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(4)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	34		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GAGCTTGGAGGACTACATCAA	0.602000													7	21					0	0	1	0	0
CDKL5	6792	broad.mit.edu	37	X	18643338	18643338	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chrX:18643338C>T	ENST00000379989.3	+	18	2752	c.2467C>T	c.(2467-2469)Ccc>Tcc	p.P823S	CDKL5_ENST00000379996.3_Missense_Mutation_p.P823S	NM_001037343.1	NP_001032420.1	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	823					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|skin(5)|stomach(1)	44	Hepatocellular(33;0.183)					GGAGTGGCGCCCCGAGAAGAT	0.537000													32	81					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215799198	215799198	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:215799198C>T	ENST00000366943.2	-	73	15992	c.15606G>A	c.(15604-15606)gaG>gaA	p.E5202E	USH2A_ENST00000307340.3_Silent_p.E5178E			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	5178					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TCATCAGGTCCTCTTCATCCA	0.388000										HNSCC(13;0.011)			54	65					0	0	1	0	0
FLT3	2322	broad.mit.edu	37	13	28608113	28608113	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr13:28608113G>A	ENST00000380982.4	-	15	1934	c.1853C>T	c.(1852-1854)tCa>tTa	p.S618L	FLT3_ENST00000537084.1_Missense_Mutation_p.S618L|FLT3_ENST00000241453.7_Missense_Mutation_p.S618L			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	618	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity	p.G617_S618ins21(1)		NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	AAAAGCACCTGATCCTAGTAC	0.403000			"""Mis, O"""		"""AML, ALL"""								69	145					0	0	1	0	0
NKX2-2	4821	broad.mit.edu	37	20	21492807	21492807	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr20:21492807C>T	ENST00000377142.4	-	2	932	c.576G>A	c.(574-576)atG>atA	p.M192I	NKX2-2-AS1_ENST00000549659.1_RNA	NM_002509.3	NP_002500.1	O95096	NKX22_HUMAN	NK2 homeobox 2	192					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21						GCGTCACCTCCATACCTTTCT	0.667000													14	28					0	0	1	0	0
IGHV3-30	28439	broad.mit.edu	37	14	106791075	106791075	+	RNA	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr14:106791075G>A	ENST00000390613.2	-	0	360																											CGTGTTCTTGGAATTGTCTCT	0.502000													106	1212					0	0	1	0	0
NSRP1	84081	broad.mit.edu	37	17	28445171	28445171	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr17:28445171G>A	ENST00000247026.5	+	2	157	c.94G>A	c.(94-96)Gat>Aat	p.D32N	NSRP1_ENST00000479218.2_Silent_p.*42*|NSRP1_ENST00000584423.1_Missense_Mutation_p.D32N|NSRP1_ENST00000540900.3_Intron	NM_001261467.1|NM_032141.3	NP_001248396.1|NP_115517.1	Q9H0G5	NSRP1_HUMAN	nuclear speckle splicing regulatory protein 1	32	Poly-Asp.				developmental process|nucleocytoplasmic transport|regulation of alternative nuclear mRNA splicing, via spliceosome	nuclear speck|ribonucleoprotein complex	mRNA binding|protein binding			autonomic_ganglia(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)	14						GTTTGGGAATGATTCTGATGA	0.338000													43	99					0	0	1	0	0
KRTAP10-6	386674	broad.mit.edu	37	21	46011539	46011539	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr21:46011539G>A	ENST00000400368.1	-	1	847	c.827C>T	c.(826-828)tCt>tTt	p.S276F	TSPEAR_ENST00000323084.4_Intron	NM_198688.2	NP_941961.2	P60371	KR106_HUMAN	keratin associated protein 10-6	276	29 X 5 AA repeats of C-C-X(3).					keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(6)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	23						GGAAGCCCCAGAGCAGACGGG	0.647000													56	156					0	0	1	0	0
ZER1	10444	broad.mit.edu	37	9	131513739	131513739	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr9:131513739G>A	ENST00000291900.2	-	6	1397	c.991C>T	c.(991-993)Ctc>Ttc	p.L331F		NM_006336.2	NP_006327.2	Q7Z7L7	ZER1_HUMAN	zyg-11 related, cell cycle regulator	331					ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			endometrium(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	15						TTCTCAAAGAGCCCGAGGAAC	0.587000													44	39					0	0	1	0	0
TMEM200A	114801	broad.mit.edu	37	6	130761678	130761678	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr6:130761678G>A	ENST00000392429.1	+	2	2489	c.111G>A	c.(109-111)aaG>aaA	p.K37K	TMEM200A_ENST00000545622.1_Silent_p.K37K|TMEM200A_ENST00000296978.3_Silent_p.K37K	NM_052913.2	NP_443145.1	Q86VY9	T200A_HUMAN	transmembrane protein 200A	37						integral to membrane				NS(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(30)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		CCCAAGAGAAGAAGCCCATCA	0.537000													46	79					0	0	1	0	0
C3orf30	152405	broad.mit.edu	37	3	118865231	118865231	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr3:118865231C>T	ENST00000295622.1	+	1	235	c.195C>T	c.(193-195)tcC>tcT	p.S65S		NM_152539.2	NP_689752.2	Q96M34	CC030_HUMAN	chromosome 3 open reading frame 30	65										NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(20)|ovary(2)|prostate(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(114;0.222)		AGGCTGAATCCAGCATATTTA	0.522000													12	26					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185800759	185800759	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr2:185800759C>T	ENST00000302277.6	+	4	1230	c.636C>T	c.(634-636)atC>atT	p.I212I		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	212						intracellular	zinc ion binding	p.I212I(1)		NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						GACACAAAATCGGCTTTTCTT	0.438000													33	98					0	0	1	0	0
OR2M4	26245	broad.mit.edu	37	1	248402594	248402594	+	Missense_Mutation	SNP	C	C	T	rs61743231		TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:248402594C>T	ENST00000306687.1	+	1	364	c.364C>T	c.(364-366)Cgc>Tgc	p.R122C		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GGCTTATGACCGCTATGTGGC	0.463000													32	137					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30695081	30695081	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr8:30695081G>A	ENST00000256246.2	-	3	7644	c.7570C>T	c.(7570-7572)Cct>Tct	p.P2524S		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	2524										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TCTAGATCAGGATGGACATCT	0.373000													31	96					0	0	1	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29977359	29977359	+	RNA	SNP	G	G	A	rs3831361	by1000genomes	TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr6:29977359G>A	ENST00000376797.3	-	0	731				ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|HLA-J_ENST00000462773.1_RNA																							ATTTGTTCATGCCTTCCCTTT	0.453000													7	89					0	0	1	0	0
PVALB	5816	broad.mit.edu	37	22	37211171	37211171	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr22:37211171C>T	ENST00000216200.5	-	3	225	c.170G>A	c.(169-171)gGc>gAc	p.G57D	PVALB_ENST00000417718.2_Missense_Mutation_p.G57D|PVALB_ENST00000404171.1_Missense_Mutation_p.G25D	NM_002854.2	NP_002845.1	P20472	PRVA_HUMAN	parvalbumin	57	EF-hand 1.						calcium ion binding			large_intestine(1)|lung(1)|skin(1)	3						CTCGATGAAGCCACTTTTGTC	0.557000													19	33					0	0	1	0	0
BEND4	389206	broad.mit.edu	37	4	42122105	42122105	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr4:42122105G>A	ENST00000502486.1	-	5	1932	c.1353C>T	c.(1351-1353)cgC>cgT	p.R451R	BEND4_ENST00000504360.1_Intron	NM_207406.3	NP_997289.2	Q6ZU67	BEND4_HUMAN	BEN domain containing 4	451	BEN.									NS(2)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26						GATCCAGAGGGCGTCTTTCGG	0.502000													13	22					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113377521	113377521	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr3:113377521C>T	ENST00000316407.4	-	7	3418	c.3008G>A	c.(3007-3009)gGt>gAt	p.G1003D	KIAA2018_ENST00000478658.1_Missense_Mutation_p.G1003D|KIAA2018_ENST00000491165.1_Intron	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	1003					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						TGTAGTTAAACCTTGCCCCTT	0.383000													61	149					0	0	1	0	0
PRKCQ	5588	broad.mit.edu	37	10	6472801	6472801	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr10:6472801C>T	ENST00000263125.5	-	17	2035	c.1936G>A	c.(1936-1938)Gag>Aag	p.E646K	PRKCQ_ENST00000539722.1_Missense_Mutation_p.E521K|PRKCQ_ENST00000397176.2_Missense_Mutation_p.E583K	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	646	AGC-kinase C-terminal.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						GGGTCAATCTCCTTCCGTTCA	0.607000													19	32					0	0	1	0	0
RTTN	25914	broad.mit.edu	37	18	67753871	67753871	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr18:67753871A>C	ENST00000255674.6	-	32	4638	c.4352T>G	c.(4351-4353)aTt>aGt	p.I1451S	RTTN_ENST00000437017.1_Missense_Mutation_p.I1451S|RTTN_ENST00000454359.1_3'UTR	NM_173630.3	NP_775901.3	Q86VV8	RTTN_HUMAN	rotatin	1451							binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(35)|ovary(4)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Esophageal squamous(42;0.129)				ATCCTTTATAATTTCTGTAGG	0.254000													66	152					0	0	1	0	0
ACACA	31	broad.mit.edu	37	17	35518799	35518799	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr17:35518799G>A	ENST00000353139.5	-	42	5726	c.5245C>T	c.(5245-5247)Cca>Tca	p.P1749S	ACACA_ENST00000394406.2_Missense_Mutation_p.P1712S|ACACA_ENST00000360679.3_Missense_Mutation_p.P1654S|ACACA_ENST00000335166.5_Missense_Mutation_p.P1634S	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	1712	Carboxyltransferase.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TAGATGCGTGGAATACCTTCT	0.463000													40	123					0	0	1	0	0
FBXO40	51725	broad.mit.edu	37	3	121341969	121341969	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr3:121341969C>T	ENST00000338040.4	+	3	2107	c.1693C>T	c.(1693-1695)Cat>Tat	p.H565Y		NM_016298.3	NP_057382.2	Q9UH90	FBX40_HUMAN	F-box protein 40	565					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(11)|lung(19)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	46				GBM - Glioblastoma multiforme(114;0.189)		TCTTTTGGGTCATGGAGGAAA	0.512000													37	86					0	0	1	0	0
PPFIA1	8500	broad.mit.edu	37	11	70179621	70179621	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr11:70179621G>A	ENST00000253925.7	+	10	1473	c.1258G>A	c.(1258-1260)Gaa>Aaa	p.E420K	AP000487.6_ENST00000528607.1_RNA|PPFIA1_ENST00000389547.3_Missense_Mutation_p.E420K	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	420					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			ACGACAGATGGAAGCACAGTT	0.537000													9	35					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	406940	406940	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr9:406940C>T	ENST00000432829.2	+	28	3513	c.3197C>T	c.(3196-3198)tCc>tTc	p.S1066F	DOCK8_ENST00000469391.1_Missense_Mutation_p.S1034F|DOCK8_ENST00000453981.1_Missense_Mutation_p.S1134F|DOCK8_ENST00000382329.1_Missense_Mutation_p.S601F	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1134					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		AACTCAAGCTCCTGCTCCAGC	0.527000													45	77					0	0	1	0	0
ERCC3	2071	broad.mit.edu	37	2	128047035	128047035	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr2:128047035G>C	ENST00000493187.2	-	6	971	c.508C>G	c.(508-510)Cga>Gga	p.R170G	ERCC3_ENST00000285398.2_Missense_Mutation_p.R234G			P19447	ERCC3_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 3	234					cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	31	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		TCTGTCACTCGGGAAGTGGAG	0.468000			"""Mis, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				16	64					0	0	1	0	0
DEAF1	10522	broad.mit.edu	37	11	681007	681007	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr11:681007G>A	ENST00000382409.3	-	7	1437	c.953C>T	c.(952-954)tCc>tTc	p.S318F	DEAF1_ENST00000338675.6_Intron|DEAF1_ENST00000525904.1_5'UTR	NM_021008.2	NP_066288.2	O75398	DEAF1_HUMAN	DEAF1 transcription factor	318					embryonic skeletal system development|germ cell development|neural tube closure|regulation of mammary gland epithelial cell proliferation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|extracellular region|nucleus	protein binding|zinc ion binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	24		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;1.76e-27)|Epithelial(43;8.42e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.55e-21)|BRCA - Breast invasive adenocarcinoma(625;4.83e-05)|Lung(200;0.0259)|LUSC - Lung squamous cell carcinoma(625;0.075)		GTTCTTGGGGGAGTCCTTCTT	0.527000													17	39					0	0	1	0	0
ELFN2	114794	broad.mit.edu	37	22	37770283	37770283	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr22:37770283G>A	ENST00000402918.1	-	3	2077	c.1292C>T	c.(1291-1293)tCt>tTt	p.S431F	ELFN2_ENST00000349653.3_Missense_Mutation_p.S431F|RP1-63G5.5_ENST00000430883.1_RNA	NM_052906.3	NP_443138.2	Q5R3F8	LRFN6_HUMAN	extracellular leucine-rich repeat and fibronectin type III domain containing 2	431						cell surface|integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	35	Melanoma(58;0.0574)					GACGTTGACAGACTTCTGCTT	0.607000													37	86					0	0	1	0	0
CDC14B	8555	broad.mit.edu	37	9	99266040	99266040	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr9:99266040G>A	ENST00000375241.1	-	14	1943	c.1492C>T	c.(1492-1494)Cgt>Tgt	p.R498C	CDC14B_ENST00000265659.2_Intron|CDC14B_ENST00000375240.3_Missense_Mutation_p.R459C|CDC14B_ENST00000463569.1_3'UTR|CDC14B_ENST00000375242.3_Missense_Mutation_p.R461C	NM_003671.3|NM_033331.2	NP_003662.1|NP_201588.1	O60729	CC14B_HUMAN	cell division cycle 14B	498					activation of anaphase-promoting complex activity|DNA repair|G2/M transition DNA damage checkpoint	nucleolus|nucleoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)	15		Acute lymphoblastic leukemia(62;0.0559)				TTTACTTAACGCAAGACTGTT	0.383000													7	96					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94652062	94652062	+	Silent	SNP	T	T	C	rs144875752	byFrequency	TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:94652062T>C	ENST00000260526.6	-	16	1955	c.1773A>G	c.(1771-1773)tcA>tcG	p.S591S	ARHGAP29_ENST00000482481.1_5'UTR	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	591					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TACCAGTTTCTGAAGGGGAAG	0.378000													11	176					0	0	1	0	0
ZNF483	158399	broad.mit.edu	37	9	114304990	114304990	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr9:114304990C>T	ENST00000309235.5	+	6	1933	c.1775C>T	c.(1774-1776)tCa>tTa	p.S592L	ZNF483_ENST00000358151.4_Intron	NM_133464.2	NP_597721.2	Q8TF39	ZN483_HUMAN	zinc finger protein 483	592					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(11)|ovary(1)|skin(5)	31						AGGCAGAATTCATGCCTTACC	0.398000													59	55					0	0	1	0	0
FCAMR	83953	broad.mit.edu	37	1	207135788	207135788	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:207135788T>C	ENST00000324852.4	-	5	896	c.422A>G	c.(421-423)tAc>tGc	p.Y141C	FCAMR_ENST00000400962.3_Missense_Mutation_p.Y141C|FCAMR_ENST00000450945.2_Missense_Mutation_p.Y141C	NM_001170631.1	NP_001164102.1	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity	96	Ig-like V-type.					integral to membrane|plasma membrane	receptor activity			endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)|stomach(1)	11						ACGGCACCAGTACTTCCTCTG	0.577000													17	55					0	0	1	0	0
LOC643201	643201	broad.mit.edu	37	5	175572158	175572158	+	RNA	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr5:175572158C>T	ENST00000515403.1	-	0	2959				RP11-826N14.4_ENST00000510029.1_lincRNA	NR_036494.1																						AACACCACTTCATACTGAGGT	0.378000													3	14					0	0	1	0	0
PGBD1	84547	broad.mit.edu	37	6	28268987	28268987	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr6:28268987C>T	ENST00000405948.2	+	7	1776	c.1356C>T	c.(1354-1356)gtC>gtT	p.V452V	PGBD1_ENST00000259883.3_Silent_p.V452V	NM_001184743.1|NM_032507.3	NP_001171672.1|NP_115896.1	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	452					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	41						GCTTGGAAGTCACAGTTCAGG	0.363000													89	164					0	0	1	0	0
TRBV2	28620	broad.mit.edu	37	7	142000775	142000775	+	RNA	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr7:142000775C>T	ENST00000455382.2	+	0	29																											TCCACAGGACCAGATGCCTGA	0.542000													10	48					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34150133	34150133	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chrX:34150133G>A	ENST00000346193.3	-	1	314	c.263C>T	c.(262-264)gCt>gTt	p.A88V		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	88										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						TTTGGGGTCAGCTTGGGGACC	0.542000													42	64					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				75	98					0	0	1	0	0
OR6C65	403282	broad.mit.edu	37	12	55794578	55794578	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr12:55794578C>T	ENST00000379665.2	+	1	365	c.266C>T	c.(265-267)aCc>aTc	p.T89I		NM_001005518.1	NP_001005518.1	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C, member 65	89					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(3)|lung(9)	15						GGAGACACAACCATTTCCTAT	0.353000													37	120					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508414	37508414	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr10:37508414G>A	ENST00000374660.1	+	40	4062	c.3963G>A	c.(3961-3963)agG>agA	p.R1321R	ANKRD30A_ENST00000361713.1_Silent_p.R1202R|ANKRD30A_ENST00000602533.1_Silent_p.R1202R			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1258						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						AAGCTCAAAGGAAATCCAAAA	0.368000													17	34					0	0	1	0	0
ZNF605	100289635	broad.mit.edu	37	12	133502309	133502309	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr12:133502309T>A	ENST00000360187.4	-	5	1924	c.1576A>T	c.(1576-1578)Att>Ttt	p.I526F	ZNF605_ENST00000392321.3_Missense_Mutation_p.I557F	NM_183238.3	NP_899061.1	Q86T29	ZN605_HUMAN	zinc finger protein 605	526					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(16)|large_intestine(5)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	28	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00227)|all_epithelial(31;0.142)		OV - Ovarian serous cystadenocarcinoma(86;9.24e-09)|Epithelial(86;2.11e-07)|all cancers(50;5.27e-06)		CCTGTATGAATTCTCTGATGC	0.423000													43	87					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56087025	56087025	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr12:56087025T>C	ENST00000257880.7	-	21	2963	c.2744A>G	c.(2743-2745)aAt>aGt	p.N915S	ITGA7_ENST00000452168.2_Missense_Mutation_p.N778S|ITGA7_ENST00000257879.6_Missense_Mutation_p.N871S|ITGA7_ENST00000394229.2_Missense_Mutation_p.N871S|ITGA7_ENST00000347027.6_Missense_Mutation_p.N865S|ITGA7_ENST00000394230.2_Missense_Mutation_p.N875S|ITGA7_ENST00000555728.1_Missense_Mutation_p.N915S|ITGA7_ENST00000553804.1_Missense_Mutation_p.N875S			Q13683	ITA7_HUMAN	integrin, alpha 7	915					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						CCACTTCCCATTGGCAATCTC	0.577000													27	56					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135692572	135692572	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr5:135692572G>A	ENST00000513104.1	-	2	786	c.504C>T	c.(502-504)atC>atT	p.I168I	TRPC7_ENST00000355180.3_Silent_p.I168I|TRPC7_ENST00000426057.2_Silent_p.I168I	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	168					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CCGCCAGGATGATGGGCGTGA	0.637000													43	123					0	0	1	0	0
AHCTF1	25909	broad.mit.edu	37	1	247013018	247013018	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:247013018C>T	ENST00000366508.1	-	33	6531	c.6395G>A	c.(6394-6396)aGc>aAc	p.S2132N	AHCTF1_ENST00000391829.2_Missense_Mutation_p.S2097N|AHCTF1_ENST00000326225.3_Missense_Mutation_p.S2106N|AHCTF1_ENST00000470300.1_5'UTR			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	2097	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CCGAGTCCTGCTGCTGCGGGA	0.453000													34	135					0	0	1	0	0
IL17A	3605	broad.mit.edu	37	6	52052534	52052534	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr6:52052534G>A	ENST00000340057.1	+	2	206	c.161G>A	c.(160-162)cGg>cAg	p.R54Q		NM_002190.2	NP_002181.1	Q16552	IL17_HUMAN	interleukin 17A	54					apoptosis|cell-cell signaling|fibroblast activation|immune response|inflammatory response|positive regulation of interleukin-23 production|positive regulation of osteoclast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein glycosylation	extracellular space	cytokine activity	p.R54L(1)|p.R54Q(1)		endometrium(3)|large_intestine(2)|lung(8)|prostate(3)|skin(1)	17	Lung NSC(77;0.116)					ATCCATAACCGGAATACCAAT	0.458000													43	152					0	0	1	0	0
GOLIM4	27333	broad.mit.edu	37	3	167750415	167750415	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr3:167750415G>A	ENST00000470487.1	-	9	1758	c.1069C>T	c.(1069-1071)Ctt>Ttt	p.L357F	GOLIM4_ENST00000309027.4_Missense_Mutation_p.L329F	NM_014498.3	NP_055313.1	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	357	Glu-rich.				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(5)|endometrium(2)|large_intestine(8)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						TCCTCCTCAAGATGTTCTGCT	0.572000													48	147					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	101105711	101105711	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr8:101105711G>A	ENST00000360863.6	-	3	275	c.81C>T	c.(79-81)ttC>ttT	p.F27F	RGS22_ENST00000523437.1_Silent_p.F27F|RGS22_ENST00000523287.1_5'UTR	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	27					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity	p.F27L(2)	RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			AGTCTACAAGGAAATCATCTG	0.264000													35	86					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121000846	121000846	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr11:121000846C>T	ENST00000392793.1	+	10	3138	c.2867C>T	c.(2866-2868)tCt>tTt	p.S956F	TECTA_ENST00000264037.2_Missense_Mutation_p.S956F			O75443	TECTA_HUMAN	tectorin alpha	956					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CTCTGTGACTCTGTGGCCCGG	0.597000													35	35					0	0	1	0	0
SERPINA6	866	broad.mit.edu	37	14	94780401	94780401	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr14:94780401G>A	ENST00000341584.3	-	2	731	c.585C>T	c.(583-585)ctC>ctT	p.L195L		NM_001756.3	NP_001747.2	P08185	CBG_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	195					regulation of proteolysis|transport	extracellular space	serine-type endopeptidase inhibitor activity|steroid binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	26		all_cancers(154;0.0482)|all_epithelial(191;0.166)		COAD - Colon adenocarcinoma(157;0.211)	Alclometasone(DB00240)|Beclomethasone(DB00394)|Ciclesonide(DB01410)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Halobetasol Propionate(DB00596)|Medrysone(DB00253)|Mitotane(DB00648)|Paramethasone(DB01384)|Prednisolone(DB00860)|Rimexolone(DB00896)|Triamcinolone(DB00620)	TGACCAGGACGAGGATGGCTG	0.498000													27	86					0	0	1	0	0
NLRX1	79671	broad.mit.edu	37	11	119043077	119043077	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr11:119043077C>T	ENST00000409109.1	+	3	670	c.83C>T	c.(82-84)cCc>cTc	p.P28L	NLRX1_ENST00000292199.2_Missense_Mutation_p.P28L|NLRX1_ENST00000409991.1_Missense_Mutation_p.P28L|NLRX1_ENST00000525863.1_Missense_Mutation_p.P28L|NLRX1_ENST00000409265.4_Missense_Mutation_p.P28L			Q86UT6	NLRX1_HUMAN	NLR family member X1	28					innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			cervix(1)|endometrium(2)|kidney(2)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	22	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GATCGTATCCCCTTCCTGATC	0.527000													20	44					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34150050	34150050	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chrX:34150050C>T	ENST00000346193.3	-	1	397	c.346G>A	c.(346-348)Gcg>Acg	p.A116T		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	116										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						TCTACGAACGCCTTCCGTGCT	0.547000													44	59					0	0	1	0	0
LPO	4025	broad.mit.edu	37	17	56343598	56343598	+	Missense_Mutation	SNP	G	G	A	rs144914036	byFrequency	TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr17:56343598G>A	ENST00000262290.4	+	11	1920	c.1604G>A	c.(1603-1605)cGc>cAc	p.R535H	LPO_ENST00000543544.1_Missense_Mutation_p.R476H|LPO_ENST00000421678.2_Missense_Mutation_p.R452H|LPO_ENST00000582328.1_Missense_Mutation_p.R452H	NM_006151.2	NP_006142.1	P22079	PERL_HUMAN	lactoperoxidase	535					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity	p.R535H(1)		breast(5)|cervix(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30						GGAGAGCTGCGCAACAAGCTT	0.547000													15	37					0	0	1	0	0
GNLY	10578	broad.mit.edu	37	2	85922457	85922457	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr2:85922457C>T	ENST00000409696.3	+	3	304	c.22C>T	c.(22-24)Cgt>Tgt	p.R8C	GNLY_ENST00000524600.1_Missense_Mutation_p.R50C|GNLY_ENST00000533041.1_3'UTR|GNLY_ENST00000263863.4_Missense_Mutation_p.R23C	NM_012483.2	NP_036615.2	P22749	GNLY_HUMAN	granulysin	23					cellular defense response|defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				endometrium(4)|kidney(10)|large_intestine(1)|lung(1)|skin(2)|upper_aerodigestive_tract(1)	19						GGTCTTCTCTCGTCTGAGCCC	0.627000													12	22					0	0	1	0	0
OTC	5009	broad.mit.edu	37	X	38260574	38260574	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chrX:38260574C>A	ENST00000039007.4	+	5	585	c.433C>A	c.(433-435)Caa>Aaa	p.Q145K	TM4SF2_ENST00000465127.1_Intron|OTC_ENST00000488812.1_3'UTR	NM_000531.5	NP_000522.3	P00480	OTC_HUMAN	ornithine carbamoyltransferase	145					arginine biosynthetic process|urea cycle	mitochondrial matrix|ornithine carbamoyltransferase complex	ornithine carbamoyltransferase activity	p.Q145K(1)		breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22					L-Citrulline(DB00155)|L-Ornithine(DB00129)	AGTGTATAAACAATCAGATTT	0.403000													6	33					0.00198382	0.00198382	1	1	0
LAMA2	3908	broad.mit.edu	37	6	129722465	129722465	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr6:129722465G>A	ENST00000421865.2	+	38	5591	c.5542G>A	c.(5542-5544)Gaa>Aaa	p.E1848K		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1848	Domain II and I.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TCTTGCAGATGAAATCAACTC	0.398000													36	50					0	0	1	0	0
ZC3H10	84872	broad.mit.edu	37	12	56515570	56515570	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr12:56515570C>T	ENST00000257940.2	+	3	1500	c.1224C>T	c.(1222-1224)atC>atT	p.I408I	RP11-603J24.5_ENST00000549438.1_RNA|RP11-603J24.5_ENST00000550947.1_RNA	NM_032786.1	NP_116175.1	Q96K80	ZC3HA_HUMAN	zinc finger CCCH-type containing 10	408							nucleic acid binding|zinc ion binding			breast(1)|endometrium(4)|large_intestine(1)|lung(2)|prostate(2)|skin(1)	11			OV - Ovarian serous cystadenocarcinoma(18;0.12)			TGGCAGGAATCACAATGAGCC	0.587000													10	36					0	0	1	0	0
STAT4	6775	broad.mit.edu	37	2	191899303	191899303	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr2:191899303C>T	ENST00000392320.2	-	18	1905	c.1591G>A	c.(1591-1593)Ggt>Agt	p.G531S	STAT4_ENST00000358470.4_Missense_Mutation_p.G531S	NM_003151.3	NP_003142.1	Q14765	STAT4_HUMAN	signal transducer and activator of transcription 4	531					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(4)|endometrium(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			GTGAGGTGACCATCACTGTAG	0.358000													32	101					0	0	1	0	0
C17orf98	388381	broad.mit.edu	37	17	36997591	36997591	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr17:36997591C>T	ENST00000398575.4	-	1	117	c.52G>A	c.(52-54)Gac>Aac	p.D18N		NM_001080465.2	NP_001073934.1	A8MV24	CQ098_HUMAN	chromosome 17 open reading frame 98	18										endometrium(5)|kidney(1)|large_intestine(1)|lung(3)|pancreas(1)|prostate(3)	14						GCCACCCCGTCCAAGATAAAG	0.647000													13	39					0	0	1	0	0
BOLA1	51027	broad.mit.edu	37	1	149871724	149871724	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:149871724A>C	ENST00000369153.2	+	3	776	c.112A>C	c.(112-114)Acg>Ccg	p.T38P	BOLA1_ENST00000369150.1_Missense_Mutation_p.T38P|BOLA1_ENST00000369152.5_Missense_Mutation_p.T38P|BOLA1_ENST00000476344.1_3'UTR			Q9Y3E2	BOLA1_HUMAN	bolA family member 1	38						extracellular region	protein binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	10	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			CGCCATTCGCACGAAGTTGGA	0.692000													10	45					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3832835	3832835	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr16:3832835G>A	ENST00000262367.5	-	6	2232	c.1423C>T	c.(1423-1425)Ccc>Tcc	p.P475S	CREBBP_ENST00000382070.3_Missense_Mutation_p.P437S	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	475					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GGGTCTATGGGATTTGGGTTA	0.542000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						27	60					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54825182	54825182	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr15:54825182G>A	ENST00000545554.1	+	25	5614	c.5614G>A	c.(5614-5616)Gga>Aga	p.G1872R	UNC13C_ENST00000260323.11_Missense_Mutation_p.G1872R|UNC13C_ENST00000537900.1_Missense_Mutation_p.G1870R			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1872					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GAGAGCAAATGGAAACACCAC	0.303000													7	10					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232629309	232629309	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:232629309G>A	ENST00000366630.1	-	3	1939	c.1581C>T	c.(1579-1581)tcC>tcT	p.S527S	SIPA1L2_ENST00000486472.1_5'UTR|SIPA1L2_ENST00000262861.4_Silent_p.S527S			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	527					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				AGTTGAACTGGGATCCTTCTT	0.473000													113	386					0	0	1	0	0
GABRA5	2558	broad.mit.edu	37	15	27193269	27193269	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr15:27193269C>T	ENST00000335625.5	+	11	2166	c.1278C>T	c.(1276-1278)gaC>gaT	p.D426D	GABRA5_ENST00000355395.5_Silent_p.D426D|GABRA5_ENST00000400081.3_Silent_p.D426D	NM_000810.3	NP_000801.1	P31644	GBRA5_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 5	426					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(26)|ovary(1)|upper_aerodigestive_tract(1)	49		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GCAAAATTGACAAAATGTCCC	0.448000													6	31					0	0	1	0	0
CPZ	8532	broad.mit.edu	37	4	8613798	8613798	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr4:8613798G>A	ENST00000429646.2	+	6	2889	c.96G>A	c.(94-96)atG>atA	p.M32I	CPZ_ENST00000382480.2_Missense_Mutation_p.M287I|CPZ_ENST00000360986.4_Missense_Mutation_p.M424I|CPZ_ENST00000315782.6_Missense_Mutation_p.M413I			Q66K79	CBPZ_HUMAN	carboxypeptidase Z	424	FZ.				proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(23)|ovary(3)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						TCCACCCCATGATGATGGACA	0.562000													9	23					0	0	1	0	0
SLC30A9	10463	broad.mit.edu	37	4	42077755	42077755	+	Silent	SNP	T	T	G			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr4:42077755T>G	ENST00000264451.6	+	16	1680	c.1500T>G	c.(1498-1500)gtT>gtG	p.V500V		NM_006345.3	NP_006336.3	Q6PML9	ZNT9_HUMAN	solute carrier family 30 (zinc transporter), member 9	500					nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						ATGGGCGAGTTGTTACAAGAT	0.328000													24	55					0	0	1	0	0
SKIV2L	6499	broad.mit.edu	37	6	31930804	31930804	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr6:31930804C>T	ENST00000375394.2	+	13	1452	c.1339C>T	c.(1339-1341)Cac>Tac	p.H447Y	SKIV2L_ENST00000544581.1_Missense_Mutation_p.H254Y	NM_006929.4	NP_008860.4	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like (S. cerevisiae)	447	Helicase ATP-binding.					nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|large_intestine(1)|ovary(1)	4						GCTACCTGACCACGTTTCTAT	0.607000													11	51					0	0	1	0	0
BAI2	576	broad.mit.edu	37	1	32196407	32196407	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:32196407G>A	ENST00000373658.3	-	29	4715	c.4374C>T	c.(4372-4374)tcC>tcT	p.S1458S	BAI2_ENST00000527361.1_Silent_p.S1425S|BAI2_ENST00000398538.1_Silent_p.S1446S|BAI2_ENST00000465256.1_5'UTR|BAI2_ENST00000398542.1_Silent_p.S1358S|BAI2_ENST00000398547.1_Silent_p.S1391S|BAI2_ENST00000398556.3_Silent_p.S1373S|BAI2_ENST00000257070.4_Silent_p.S1425S|BAI2_ENST00000440175.2_Silent_p.S1067S|BAI2_ENST00000373655.2_Silent_p.S1458S	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	1458					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.S1458S(1)		breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		TCACCTCCAGGGAGCCCATCT	0.682000													23	42					0	0	1	0	0
MELK	9833	broad.mit.edu	37	9	36671008	36671008	+	Missense_Mutation	SNP	G	G	A	rs2068826		TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr9:36671008G>A	ENST00000543751.1	+	15	1568	c.1423G>A	c.(1423-1425)Gaa>Aaa	p.E475K	MELK_ENST00000541717.1_Missense_Mutation_p.E466K|MELK_ENST00000536987.1_Missense_Mutation_p.E376K|MELK_ENST00000298048.2_Missense_Mutation_p.E507K|MELK_ENST00000545008.1_Missense_Mutation_p.E436K|MELK_ENST00000536860.1_Missense_Mutation_p.E459K|MELK_ENST00000538311.1_Missense_Mutation_p.E313K|MELK_ENST00000536329.1_Missense_Mutation_p.E436K	NM_001256689.1	NP_001243618.1	Q14680	MELK_HUMAN	maternal embryonic leucine zipper kinase	507						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)	29		Acute lymphoblastic leukemia(2;1.09e-08)|all_hematologic(2;8.15e-06)	STAD - Stomach adenocarcinoma(86;0.228)			CCGCTCAGTGGAATTGGATCT	0.488000													34	39					0	0	1	0	0
STK19	8859	broad.mit.edu	37	6	31939967	31939967	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr6:31939967G>A	ENST00000375331.2	+	1	360	c.194G>A	c.(193-195)gGg>gAg	p.G65E	STK19_ENST00000375333.2_Missense_Mutation_p.G65E|DOM3Z_ENST00000337523.5_5'UTR|DOM3Z_ENST00000478221.1_5'UTR|DOM3Z_ENST00000375349.3_5'UTR	NM_004197.1	NP_004188.1	P49842	STK19_HUMAN	serine/threonine kinase 19	65						nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			skin(5)|upper_aerodigestive_tract(2)	7						GGCCGGCGTGGGGCCCGGCCT	0.701000													23	39					0	0	1	0	0
ACOXL	55289	broad.mit.edu	37	2	111666450	111666450	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr2:111666450G>A	ENST00000389811.4	+	11	1097	c.873G>A	c.(871-873)ctG>ctA	p.L291L	ACOXL_ENST00000439055.1_Silent_p.L291L			Q9NUZ1	ACOXL_HUMAN	acyl-CoA oxidase-like	291					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity			kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(1)	21						TGCCCCACCTGGCCACAGCCT	0.542000													23	56					0	0	1	0	0
INTS4P1	285905	broad.mit.edu	37	7	64639752	64639752	+	RNA	SNP	A	A	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr7:64639752A>T	ENST00000587624.1	+	0	635																											TTGATTTCCTAGTTGACATGT	0.443000													7	41					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113377522	113377522	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr3:113377522C>T	ENST00000316407.4	-	7	3417	c.3007G>A	c.(3007-3009)Ggt>Agt	p.G1003S	KIAA2018_ENST00000478658.1_Missense_Mutation_p.G1003S|KIAA2018_ENST00000491165.1_Intron	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	1003					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						GTAGTTAAACCTTGCCCCTTT	0.383000													62	150					0	0	1	0	0
SNTB1	6641	broad.mit.edu	37	8	121706063	121706063	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr8:121706063G>A	ENST00000395601.3	-	3	1071	c.657C>T	c.(655-657)tcC>tcT	p.S219S	SNTB1_ENST00000519177.1_5'UTR|SNTB1_ENST00000517992.1_Silent_p.S219S	NM_021021.3	NP_066301.1	Q13884	SNTB1_HUMAN	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)	219	PH 1.				muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(6)	24	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			CTAACCGAGGGGATTCAGGCG	0.552000													26	77					0	0	1	0	0
LANCL1	10314	broad.mit.edu	37	2	211300993	211300993	+	Silent	SNP	G	G	A	rs141302000	by1000genomes	TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr2:211300993G>A	ENST00000443314.1	-	7	1339	c.997C>T	c.(997-999)Ctg>Ttg	p.L333L	AC007970.1_ENST00000420418.1_RNA|LANCL1_ENST00000441020.3_Silent_p.L333L|LANCL1_ENST00000233714.4_Silent_p.L333L|LANCL1_ENST00000450366.2_Silent_p.L333L|AC007970.1_ENST00000433296.1_RNA|LANCL1_ENST00000431941.2_Silent_p.L333L			O43813	LANC1_HUMAN	LanC lantibiotic synthetase component C-like 1 (bacterial)	333						cytoplasm|integral to plasma membrane|microtubule cytoskeleton|nucleus	catalytic activity|G-protein coupled receptor activity|glutathione binding|low-density lipoprotein particle receptor binding|SH3 domain binding|zinc ion binding			breast(1)|large_intestine(5)|liver(1)|lung(4)|prostate(1)	12				Epithelial(149;0.00562)|Lung(261;0.0468)|LUSC - Lung squamous cell carcinoma(261;0.0495)|all cancers(144;0.0569)		TAGAGTGTCAGGAAGGCATAG	0.512000													33	81					0	0	1	0	0
SSMEM1	136263	broad.mit.edu	37	7	129856273	129856273	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr7:129856273C>T	ENST00000297819.3	+	3	749	c.698C>T	c.(697-699)tCc>tTc	p.S233F		NM_145268.3	NP_660311.1			serine-rich single-pass membrane protein 1																		GAGGAAAGTTCCATATCTGAC	0.383000													133	212					0	0	1	0	0
GMPPB	29925	broad.mit.edu	37	3	49759760	49759760	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr3:49759760G>A	ENST00000480687.1	-	8	788	c.672C>T	c.(670-672)gaC>gaT	p.D224D	GMPPB_ENST00000308388.6_Silent_p.D224D|GMPPB_ENST00000308375.6_Silent_p.D224D|AMIGO3_ENST00000535833.1_5'UTR			Q9Y5P6	GMPPB_HUMAN	GDP-mannose pyrophosphorylase B	224					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CAGTGAGGAAGTCCTTGGGCT	0.637000													10	43					0	0	1	0	0
DHX40	79665	broad.mit.edu	37	17	57665412	57665412	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr17:57665412C>T	ENST00000451169.2	+	15	1795	c.1436C>T	c.(1435-1437)cCt>cTt	p.P479L	DHX40_ENST00000425628.3_Missense_Mutation_p.P450L|DHX40_ENST00000251241.4_Missense_Mutation_p.P527L			Q8IX18	DHX40_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 40	527							ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(7)|large_intestine(6)|lung(6)|prostate(1)	20	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					TTCATTAGACCTGGTAAGATG	0.428000													14	60					0	0	1	0	0
NCF2	4688	broad.mit.edu	37	1	183543646	183543646	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:183543646G>A	ENST00000367535.3	-	4	728	c.477C>T	c.(475-477)atC>atT	p.I159I	NCF2_ENST00000367536.1_Silent_p.I159I|NCF2_ENST00000413720.1_Intron|NCF2_ENST00000418089.1_Intron	NM_000433.3	NP_000424.2	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	159					cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30						TCGCCTTGTCGATTTTGGAAT	0.463000													87	241					0	0	1	0	0
SNX16	64089	broad.mit.edu	37	8	82715355	82715355	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr8:82715355G>A	ENST00000396330.2	-	7	1296	c.790C>T	c.(790-792)Cat>Tat	p.H264Y	SNX16_ENST00000353788.4_Missense_Mutation_p.H235Y|SNX16_ENST00000345957.4_Missense_Mutation_p.H264Y|RP13-923O23.6_ENST00000524337.1_RNA	NM_022133.3	NP_071416.2	P57768	SNX16_HUMAN	sorting nexin 16	264					cell communication|early endosome to late endosome transport|endosome to lysosome transport|protein targeting to lysosome	early endosome membrane|extrinsic to endosome membrane|late endosome membrane|lysosome	identical protein binding|phosphatidylinositol binding			large_intestine(1)|ovary(1)|pancreas(1)|skin(2)	5						GTGTCTATATGAAGTTGCTTC	0.368000													29	84					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30935484	30935484	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr19:30935484G>A	ENST00000355537.3	+	2	1162	c.1015G>A	c.(1015-1017)Gag>Aag	p.E339K		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	339					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CGGCGGTGGCGAGCAGTCGGC	0.647000													37	78					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57395187	57395187	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:57395187A>G	ENST00000543257.1	-	13	2076	c.1510T>C	c.(1510-1512)Tca>Cca	p.S504P	C8B_ENST00000535057.1_Missense_Mutation_p.S494P|C8B_ENST00000371237.4_Missense_Mutation_p.S556P	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	556	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						CCAGAGCATGAAGACCAATTT	0.448000													30	54					0	0	1	0	0
INPPL1	3636	broad.mit.edu	37	11	71941316	71941316	+	Splice_Site	SNP	G	G	C			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr11:71941316G>C	ENST00000298229.2	+	9	1294		c.e9+1		INPPL1_ENST00000538751.1_Splice_Site|INPPL1_ENST00000541756.1_Splice_Site	NM_001567.3	NP_001558.3	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1						actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						CACGACCGCAGTGAGCCAGGG	0.692000													8	36					0	0	1	0	0
PCDHB13	56123	broad.mit.edu	37	5	140594154	140594154	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr5:140594154T>A	ENST00000341948.4	+	1	646	c.459T>A	c.(457-459)ttT>ttA	p.F153L		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		153	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGACTACGTTTCCTCTGAAGA	0.443000													54	114					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179702223	179702223	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr2:179702223G>A	ENST00000420890.2	-	23	3840	c.3723C>T	c.(3721-3723)tcC>tcT	p.S1241S	CCDC141_ENST00000295723.5_Silent_p.S666S|CCDC141_ENST00000480419.1_5'UTR	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	666							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			GAAGGCTGAGGGAGGAGCTGA	0.587000													18	47					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207173455	207173455	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr2:207173455G>A	ENST00000374423.3	+	5	4589	c.4203G>A	c.(4201-4203)aaG>aaA	p.K1401K		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1401							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						TGGAAGATAAGAGCTATAAAT	0.358000													18	37					0	0	1	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092610	151092610	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chrX:151092610C>T	ENST00000360243.2	+	3	741	c.474C>T	c.(472-474)tcC>tcT	p.S158S	MAGEA4_ENST00000370340.3_Silent_p.S158S|MAGEA4_ENST00000276344.2_Silent_p.S158S|MAGEA4_ENST00000370337.4_Silent_p.S158S|MAGEA4_ENST00000370335.1_Silent_p.S158S|MAGEA4_ENST00000393920.1_Silent_p.S158S|MAGEA4_ENST00000393921.1_Silent_p.S158S	NM_001011550.1	NP_001011550.1	P43358	MAGA4_HUMAN	melanoma antigen family A, 4	158	MAGE.						protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					CCTCCGAGTCCCTGAAGATGA	0.532000													66	85					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179505268	179505268	+	Splice_Site	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr2:179505268C>T	ENST00000589042.1	-	221	40947	c.40723_splice	c.e221+1	p.V13575_splice	TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000359218.5_Splice_Site_p.V4635_splice|TTN_ENST00000591111.1_Splice_Site_p.V11934_splice|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342992.6_Splice_Site_p.V11007_splice|TTN_ENST00000342175.6_Splice_Site_p.V4702_splice|TTN-AS1_ENST00000418062.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000460472.2_Splice_Site_p.V4510_splice|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11934	Ig-like 92.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGATTTGTACCTTTTGTTGGT	0.338000													56	83					0	0	1	0	0
LAD1	3898	broad.mit.edu	37	1	201352329	201352329	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:201352329G>A	ENST00000391967.2	-	7	1560	c.1259C>T	c.(1258-1260)tCt>tTt	p.S420F	LAD1_ENST00000367313.3_Missense_Mutation_p.S434F|LAD1_ENST00000488842.1_5'UTR	NM_005558.3	NP_005549.2	O00515	LAD1_HUMAN	ladinin 1	420						basement membrane	structural molecule activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|prostate(2)|skin(2)	19						AGACTTGACAGATTCTGATCT	0.592000													45	175					0	0	1	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23815598	23815598	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr4:23815598G>A	ENST00000264867.2	-	8	1627	c.1508C>T	c.(1507-1509)tCa>tTa	p.S503L	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	503					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				GGCTAGTCCTGAATTTATAAA	0.428000													40	131					0	0	1	0	0
SEMA5B	54437	broad.mit.edu	37	3	122634447	122634447	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr3:122634447C>T	ENST00000195173.4	-	14	2131	c.1828G>A	c.(1828-1830)Ggg>Agg	p.G610R	SEMA5B_ENST00000451055.2_Missense_Mutation_p.G664R|SEMA5B_ENST00000357599.3_Missense_Mutation_p.G610R			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	610					cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		CCGAAGCCCCCATCCCGTGTC	0.572000													4	30					0	0	1	0	0
TRHR	7201	broad.mit.edu	37	8	110100287	110100287	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr8:110100287G>A	ENST00000518632.1	+	2	897	c.546G>A	c.(544-546)aaG>aaA	p.K182K	TRHR_ENST00000311762.2_Silent_p.K182K			P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	182						integral to plasma membrane	thyrotropin-releasing hormone receptor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(12)|prostate(4)|skin(4)|urinary_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			GTGGCTACAAGATCTCCAGGA	0.413000													34	100					0	0	1	0	0
ALDH16A1	126133	broad.mit.edu	37	19	49967975	49967975	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr19:49967975C>T	ENST00000293350.4	+	12	1687	c.1524C>T	c.(1522-1524)ctC>ctT	p.L508L	CTD-3148I10.9_ENST00000599536.1_3'UTR|ALDH16A1_ENST00000455361.2_Silent_p.L457L|ALDH16A1_ENST00000433981.2_Silent_p.L343L|ALDH16A1_ENST00000540132.1_Silent_p.L345L	NM_153329.3	NP_699160.2	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	508							oxidoreductase activity|protein binding			cervix(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|skin(2)|urinary_tract(3)	20		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		CCTTTGGCCTCGCTGTTCCCT	0.622000													52	73					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79291087	79291087	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr4:79291087G>A	ENST00000264895.6	+	23	3258	c.2818G>A	c.(2818-2820)Gag>Aag	p.E940K	FRAS1_ENST00000325942.6_Missense_Mutation_p.E940K	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	940					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						ATGTCAATACGAGAGCTGCGC	0.478000													16	23					0	0	1	0	0
RAI2	10742	broad.mit.edu	37	X	17819063	17819063	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chrX:17819063G>A	ENST00000545871.1	-	3	1528	c.1068C>T	c.(1066-1068)ccC>ccT	p.P356P	RAI2_ENST00000331511.1_Silent_p.P356P|RAI2_ENST00000415486.3_Silent_p.P306P|RAI2_ENST00000451717.1_Silent_p.P356P|RAI2_ENST00000360011.1_Silent_p.P356P	NM_001172739.1|NM_001172743.1	NP_001166210.1|NP_001166214.1	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	356					embryo development					breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	22	Hepatocellular(33;0.183)					GTGTCTCAGGGGGAGGCTCGG	0.562000													22	40					0	0	1	0	0
CELF6	60677	broad.mit.edu	37	15	72579703	72579703	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr15:72579703G>A	ENST00000287202.5	-	12	1603	c.1349C>T	c.(1348-1350)gCc>gTc	p.A450V	CELF6_ENST00000395258.2_Missense_Mutation_p.A337V|CELF6_ENST00000543764.2_Missense_Mutation_p.A313V|CELF6_ENST00000539635.1_Missense_Mutation_p.A311V|RP11-106M3.2_ENST00000379915.4_RNA|CELF6_ENST00000567083.1_Missense_Mutation_p.A423V|RP11-106M3.3_ENST00000570175.1_RNA	NM_052840.4	NP_443072.3	Q96J87	CELF6_HUMAN	CUGBP, Elav-like family member 6	450	RRM 3.				mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(2)	13						AGCAGTCTGGGCACTAGTTGG	0.532000													28	70					0	0	1	0	0
PDK4	5166	broad.mit.edu	37	7	95217061	95217061	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr7:95217061C>T	ENST00000005178.5	-	8	1045	c.848G>A	c.(847-849)gGa>gAa	p.G283E		NM_002612.3	NP_002603.1	Q16654	PDK4_HUMAN	pyruvate dehydrogenase kinase, isozyme 4	283	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	15	all_cancers(62;1.06e-10)|all_epithelial(64;1.04e-09)|Lung NSC(181;0.128)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0151)			GTCTTCTTTTCCCAAGACAAC	0.388000													43	62					0	0	1	0	0
RWDD1	51389	broad.mit.edu	37	6	116911443	116911443	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr6:116911443C>T	ENST00000466444.2	+	5	639	c.423C>T	c.(421-423)ttC>ttT	p.F141F	RWDD1_ENST00000392526.1_Silent_p.F45F|RWDD1_ENST00000487832.2_Silent_p.F45F	NM_015952.2	NP_057036.2	Q9H446	RWDD1_HUMAN	RWD domain containing 1	141							protein binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)|skin(1)	12		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.0312)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)|Epithelial(106;0.161)		AGCAATTATTCCATGGTACTC	0.294000													15	23					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86394597	86394597	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr7:86394597C>T	ENST00000361669.2	+	2	1235	c.136C>T	c.(136-138)Cct>Tct	p.P46S	GRM3_ENST00000439827.1_Missense_Mutation_p.P46S|GRM3_ENST00000546348.1_Intron|GRM3_ENST00000536043.1_Intron|GRM3_ENST00000394720.2_Missense_Mutation_p.P44S	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	46					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GGGCCTGTTTCCTATTAACGA	0.408000													92	115					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13381792	13381792	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr3:13381792G>A	ENST00000254508.5	-	24	3317	c.3235C>T	c.(3235-3237)Ccc>Tcc	p.P1079S	NUP210_ENST00000485755.1_Intron	NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1079					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					CTGAACGGGGGAAAGACCTGT	0.572000													5	23					0	0	1	0	0
OR2T27	403239	broad.mit.edu	37	1	248814039	248814039	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:248814039G>A	ENST00000344889.3	-	1	146	c.147C>T	c.(145-147)atC>atT	p.I49I		NM_001001824.1	NP_001001824.1	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T, member 27	49					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(20)|skin(3)|stomach(1)	32	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGTCTATGTGGATGAGAATGA	0.527000													12	43					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7701964	7701964	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr17:7701964C>T	ENST00000572933.1	+	55	9947	c.8487C>T	c.(8485-8487)ttC>ttT	p.F2829F	DNAH2_ENST00000389173.2_Silent_p.F2829F			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2829	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ATGAGTCCTTCCTAGAGGACA	0.522000													30	36					0	0	1	0	0
NEURL4	84461	broad.mit.edu	37	17	7227580	7227580	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr17:7227580T>C	ENST00000399464.2	-	11	1924	c.1909A>G	c.(1909-1911)Acg>Gcg	p.T637A	NEURL4_ENST00000570460.1_Missense_Mutation_p.T615A|NEURL4_ENST00000315614.7_Missense_Mutation_p.T637A	NM_032442.2	NP_115818.2			neuralized E3 ubiquitin protein ligase 4											central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						ACGCCCACCGTGTCCCCTGCC	0.657000											OREG0024134	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	41					0	0	1	0	0
C17orf98	388381	broad.mit.edu	37	17	36997592	36997592	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr17:36997592C>T	ENST00000398575.4	-	1	116	c.51G>A	c.(49-51)ttG>ttA	p.L17L		NM_001080465.2	NP_001073934.1	A8MV24	CQ098_HUMAN	chromosome 17 open reading frame 98	17										endometrium(5)|kidney(1)|large_intestine(1)|lung(3)|pancreas(1)|prostate(3)	14						CCACCCCGTCCAAGATAAAGC	0.642000													13	38					0	0	1	0	0
RHBDF2	79651	broad.mit.edu	37	17	74475323	74475323	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr17:74475323C>A	ENST00000591885.1	-	5	859	c.309G>T	c.(307-309)tgG>tgT	p.W103C	RHBDF2_ENST00000592378.1_5'UTR|RHBDF2_ENST00000313080.4_Missense_Mutation_p.W132C|RHBDF2_ENST00000389760.4_Missense_Mutation_p.W103C			Q6PJF5	RHDF2_HUMAN	rhomboid 5 homolog 2 (Drosophila)	132					negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(4)|skin(1)	27						GCTGCCCCTCCCAGTCGCCGC	0.677000													5	11					0.000602214	0.000604939	1	1	0
NBEAP1	606	broad.mit.edu	37	15	20874863	20874863	+	RNA	SNP	T	T	C	rs62000628	by1000genomes	TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr15:20874863T>C	ENST00000556948.1	-	0	385																											TATTTTAAGGTGTGCATTATC	0.348000													5	94					0	0	1	0	0
MTFMT	123263	broad.mit.edu	37	15	65298462	65298462	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr15:65298462G>A	ENST00000220058.4	-	7	894	c.881C>T	c.(880-882)tCa>tTa	p.S294L		NM_139242.3	NP_640335.2	Q96DP5	FMT_HUMAN	mitochondrial methionyl-tRNA formyltransferase	294						mitochondrion	methionyl-tRNA formyltransferase activity|methyltransferase activity			endometrium(1)|large_intestine(3)|lung(3)|ovary(3)	10					Tetrahydrofolic acid(DB00116)	AGCAAGGACTGAACTGTTAAC	0.368000													10	39					0	0	1	0	0
KIF26B	55083	broad.mit.edu	37	1	245861536	245861536	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:245861536G>A	ENST00000366518.4	+	10	4914	c.4810G>A	c.(4810-4812)Gaa>Aaa	p.E1604K	KIF26B_ENST00000407071.2_Missense_Mutation_p.E1985K			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1985					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			GGGCCTTGGGGAACCCTTTGA	0.627000													14	44					0	0	1	0	0
GMPPB	29925	broad.mit.edu	37	3	49759761	49759761	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr3:49759761T>C	ENST00000480687.1	-	8	787	c.671A>G	c.(670-672)gAc>gGc	p.D224G	GMPPB_ENST00000308388.6_Missense_Mutation_p.D224G|GMPPB_ENST00000308375.6_Missense_Mutation_p.D224G|AMIGO3_ENST00000535833.1_5'UTR			Q9Y5P6	GMPPB_HUMAN	GDP-mannose pyrophosphorylase B	224					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AGTGAGGAAGTCCTTGGGCTG	0.637000													10	43					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5915235	5915235	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr12:5915235C>T	ENST00000356134.5	-	10	1035	c.964G>A	c.(964-966)Gat>Aat	p.D322N	ANO2_ENST00000546188.1_Missense_Mutation_p.D322N|ANO2_ENST00000327087.8_Missense_Mutation_p.D321N	NM_001278596.1|NM_001278597.1	NP_001265525.1|NP_001265526.1	Q9NQ90	ANO2_HUMAN	anoctamin 2	326						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						TCATTCATATCGTCCTCTGGA	0.478000													16	26					0	0	1	0	0
ETS1	2113	broad.mit.edu	37	11	128333448	128333448	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr11:128333448A>C	ENST00000392668.3	-	9	1266	c.1198T>G	c.(1198-1200)Tgg>Ggg	p.W400G	ETS1_ENST00000526145.1_Missense_Mutation_p.W269G|ETS1_ENST00000319397.5_Missense_Mutation_p.W356G|ETS1_ENST00000535549.1_Missense_Mutation_p.W140G|ETS1_ENST00000531611.1_Intron|ETS1_ENST00000345075.4_Missense_Mutation_p.W269G	NM_001143820.1	NP_001137292.1	P14921	ETS1_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog 1	356					cell motility|immune response|induction of apoptosis|negative regulation of cell cycle|negative regulation of cell proliferation|PML body organization|positive regulation of cellular component movement|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|response to antibiotic|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|pleura(1)|prostate(1)|upper_aerodigestive_tract(3)	35	all_hematologic(175;0.0537)	Lung NSC(97;0.000542)|all_lung(97;0.000665)|Breast(109;0.00765)|all_neural(223;0.0351)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.47e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0174)|LUSC - Lung squamous cell carcinoma(976;0.0815)|Lung(307;0.0833)		TCTCCTGTCCAGCTGATAAAA	0.458000													37	44					0	0	1	0	0
KCNA3	3738	broad.mit.edu	37	1	111215722	111215722	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:111215722C>T	ENST00000369769.2	-	1	1933	c.1710G>A	c.(1708-1710)aaG>aaA	p.K570K		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	570						voltage-gated potassium channel complex	delayed rectifier potassium channel activity	p.K570N(1)		endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		CGGTGAATATCTTTTTGATGT	0.453000													51	86					0	0	1	0	0
LOC101927060	101927060	broad.mit.edu	37	17	45128742	45128742	+	RNA	SNP	T	T	G	rs34655963	by1000genomes	TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr17:45128742T>G	ENST00000575173.1	-	0	418																											TAATGATTTTTATTATACTTT	0.328000													6	124					0	0	1	0	0
CD180	4064	broad.mit.edu	37	5	66478990	66478990	+	Missense_Mutation	SNP	G	G	A	rs150000308		TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr5:66478990G>A	ENST00000256447.4	-	3	1838	c.1681C>T	c.(1681-1683)Cgt>Tgt	p.R561C		NM_005582.2	NP_005573.2	Q99467	CD180_HUMAN	CD180 molecule	561					inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity	p.R561C(1)		cervix(1)|endometrium(2)|kidney(7)|large_intestine(12)|liver(1)|lung(8)|ovary(1)|stomach(2)	34		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		GGGAGGAGACGGGGTGAGATG	0.453000													19	50					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47897388	47897388	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr7:47897388A>T	ENST00000289672.2	-	28	4455	c.4405T>A	c.(4405-4407)Ttc>Atc	p.F1469I		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1469	REJ.				cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						AGGGTCCGGAACTCCATCTGC	0.498000													14	46					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136566630	136566630	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr2:136566630G>A	ENST00000264162.2	-	8	3297	c.3287C>T	c.(3286-3288)gCc>gTc	p.A1096V		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1096	4 X approximate repeats.			A -> T (in Ref. 1; CAA30801).	carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		TTTGATGACGGCGTGGGCTAT	0.552000													27	48					0	0	1	0	0
SLC11A1	6556	broad.mit.edu	37	2	219256178	219256178	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr2:219256178C>T	ENST00000233202.6	+	11	1464	c.1124C>T	c.(1123-1125)tCc>tTc	p.S375F	SLC11A1_ENST00000539932.1_Missense_Mutation_p.S257F	NM_000578.3	NP_000569.3	P49279	NRAM1_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1	375					activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGCAGAGCTCCACCATGACG	0.677000													6	10					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23232506	23232506	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:23232506G>A	ENST00000400191.3	+	10	1810	c.1792G>A	c.(1792-1794)Gat>Aat	p.D598N	EPHB2_ENST00000374627.1_Missense_Mutation_p.D593N|EPHB2_ENST00000374630.3_Missense_Mutation_p.D598N|EPHB2_ENST00000374632.3_Missense_Mutation_p.D599N	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	598					axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		GATCTACATCGATCCTTTCAC	0.522000													25	48					0	0	1	0	0
RAET1G	353091	broad.mit.edu	37	6	150240199	150240199	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr6:150240199G>A	ENST00000367360.2	-	3	678	c.611C>T	c.(610-612)aCc>aTc	p.T204I	RP11-244K5.1_ENST00000446954.1_RNA|RP11-244K5.8_ENST00000606915.1_RNA|RAET1G_ENST00000479265.1_Missense_Mutation_p.T204I|RP11-244K5.1_ENST00000605899.1_RNA	NM_001001788.2	NP_001001788.2	Q6H3X3	RET1G_HUMAN	retinoic acid early transcript 1G	204	MHC class I alpha-2 like.				antigen processing and presentation|immune response	integral to membrane|MHC class I protein complex	protein binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|urinary_tract(1)	13		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.73e-12)		TGGCTCCAGGGTGCTGTCCAT	0.463000													63	83					0	0	1	0	0
LOC101243545	101243545	broad.mit.edu	37	3	161147051	161147051	+	RNA	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr3:161147051G>A	ENST00000473595.1	+	0	1231				RP11-3P17.5_ENST00000602890.1_lincRNA	NR_102265.1																						CTTCTTCACAGCCTGTTTAAT	0.453000													30	82					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16990582	16990582	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr10:16990582G>A	ENST00000377833.4	-	35	5169	c.5104C>T	c.(5104-5106)Ccc>Tcc	p.P1702S		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	1702	CUB 11.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ATAGGATGGGGCATGTCGGTG	0.493000													3	27					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10350413	10350413	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr17:10350413G>A	ENST00000255381.2	-	35	5196	c.5086C>T	c.(5086-5088)Ctg>Ttg	p.L1696L	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1696					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						GTCCGTTCCAGGGATGCCCTG	0.517000													45	93					0	0	1	0	0
GPR116	221395	broad.mit.edu	37	6	46825899	46825899	+	Silent	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr6:46825899G>A	ENST00000283296.7	-	17	4029	c.3741C>T	c.(3739-3741)ttC>ttT	p.F1247F	GPR116_ENST00000265417.7_Silent_p.F1247F|GPR116_ENST00000545669.1_Silent_p.F676F|GPR116_ENST00000362015.4_Silent_p.F1247F|GPR116_ENST00000456426.2_Silent_p.F1105F	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	1247					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			ATATGATATGGAACACAAGGT	0.453000													28	80					0	0	1	0	0
CCDC114	93233	broad.mit.edu	37	19	48806008	48806008	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr19:48806008C>T	ENST00000315396.7	-	10	1754	c.1072G>A	c.(1072-1074)Gag>Aag	p.E358K		NM_144577.3	NP_653178.3	Q96M63	CC114_HUMAN	coiled-coil domain containing 114	358										cervix(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)	24		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		TCAAGGCGCTCAGCCTCCGAG	0.637000													22	39					0	0	1	0	0
TRAV20	28663	broad.mit.edu	37	14	22509243	22509243	+	RNA	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr14:22509243C>T	ENST00000390448.3	+	0	250																											TAGGCAAGATCCTGGGAAAGG	0.488000													9	35					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189587149	189587149	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr3:189587149C>T	ENST00000264731.3	+	9	1255	c.1166C>T	c.(1165-1167)tCc>tTc	p.S389F	TP63_ENST00000456148.1_Missense_Mutation_p.S291F|TP63_ENST00000449992.1_Missense_Mutation_p.S210F|TP63_ENST00000392463.2_Missense_Mutation_p.S295F|TP63_ENST00000392460.3_Missense_Mutation_p.S389F|TP63_ENST00000320472.5_Missense_Mutation_p.S389F|TP63_ENST00000392461.3_Missense_Mutation_p.S295F|TP63_ENST00000354600.5_Missense_Mutation_p.S295F|TP63_ENST00000382063.4_Missense_Mutation_p.S304F|TP63_ENST00000437221.1_Missense_Mutation_p.S295F|TP63_ENST00000440651.2_Missense_Mutation_p.S385F|TP63_ENST00000418709.2_Missense_Mutation_p.S389F	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	389					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CAGATGACATCCATCAAGAAA	0.408000										HNSCC(45;0.13)			17	47					0	0	1	0	0
CUL9	23113	broad.mit.edu	37	6	43181615	43181615	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr6:43181615G>A	ENST00000252050.4	+	29	5737	c.5653G>A	c.(5653-5655)Gaa>Aaa	p.E1885K	CUL9_ENST00000354495.3_Missense_Mutation_p.E1775K|CUL9_ENST00000372647.2_Missense_Mutation_p.E1857K|RP3-330M21.5_ENST00000500590.1_RNA	NM_015089.2	NP_055904.1	Q8IWT3	CUL9_HUMAN	cullin 9	1885					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|liver(1)|lung(30)|ovary(5)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(4)	92						AGCCCATGGGGAAAAGGGCCT	0.527000													38	103					0	0	1	0	0
KIAA1755	85449	broad.mit.edu	37	20	36869182	36869182	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr20:36869182G>A	ENST00000279024.4	-	3	1622	c.1351C>T	c.(1351-1353)Ccc>Tcc	p.P451S		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	451										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				ATGGGCTTGGGAAGTCTCCCA	0.567000													44	72					0	0	1	0	0
APOA4	337	broad.mit.edu	37	11	116691731	116691731	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr11:116691731C>T	ENST00000357780.3	-	3	1157	c.1043G>A	c.(1042-1044)aGg>aAg	p.R348K		NM_000482.3	NP_000473.2			apolipoprotein A-IV											cervix(1)|endometrium(2)|lung(10)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		GACCTTGTCCCTCAGGTCCTT	0.577000													23	27					0	0	1	0	0
PDCD6IP	10015	broad.mit.edu	37	3	33868069	33868069	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr3:33868069C>T	ENST00000307296.3	+	6	1091	c.714C>T	c.(712-714)ccC>ccT	p.P238P	PDCD6IP_ENST00000457054.2_Silent_p.P238P			Q8WUM4	PDC6I_HUMAN	programmed cell death 6 interacting protein	238	BRO1.|Interaction with CHMP4A, CHMP4B and CHMP4C.|Interaction with EIAV p9.				apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|skin(1)|stomach(1)	23						ATACTCTCCCCAAGGTCAGTT	0.313000													17	60					0	0	1	0	0
HRG	3273	broad.mit.edu	37	3	186386822	186386822	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr3:186386822C>T	ENST00000232003.4	+	2	362	c.282C>T	c.(280-282)tcC>tcT	p.S94S		NM_000412.2	NP_000403.1	P04196	HRG_HUMAN	histidine-rich glycoprotein	94	Cystatin 1.				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(12)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		CACCTGATTCCAGACGTCCAT	0.423000													52	115					0	0	1	0	0
SLC1A3	6507	broad.mit.edu	37	5	36680583	36680583	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr5:36680583G>A	ENST00000265113.4	+	8	1657	c.1181G>A	c.(1180-1182)gGa>gAa	p.G394E	CTD-2353F22.1_ENST00000510740.1_RNA|SLC1A3_ENST00000381918.3_Missense_Mutation_p.G394E	NM_004172.4	NP_004163.3	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity glutamate transporter), member 3	394					D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(23)|skin(1)	41	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	CTCCCCGTAGGAGCCACCATT	0.488000													29	63					0	0	1	0	0
ZNF532	55205	broad.mit.edu	37	18	56586580	56586580	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr18:56586580C>T	ENST00000336078.4	+	4	1837	c.1061C>T	c.(1060-1062)tCc>tTc	p.S354F	ZNF532_ENST00000591083.1_Missense_Mutation_p.S354F|ZNF532_ENST00000591808.1_Missense_Mutation_p.S354F|ZNF532_ENST00000591230.1_Missense_Mutation_p.S354F|ZNF532_ENST00000589288.1_Missense_Mutation_p.S354F	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	354					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						CCCGCAGGGTCCACACCAGCA	0.507000													22	81					0	0	1	0	0
FOXP1	27086	broad.mit.edu	37	3	71247407	71247407	+	Silent	SNP	C	C	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr3:71247407C>T	ENST00000318789.4	-	6	651	c.126G>A	c.(124-126)ccG>ccA	p.P42P	FOXP1_ENST00000468577.1_Silent_p.P42P|FOXP1_ENST00000475937.1_Silent_p.P42P|FOXP1_ENST00000484350.1_Silent_p.P42P|FOXP1_ENST00000498215.1_Silent_p.P42P|FOXP1_ENST00000318779.3_Silent_p.P42P|FOXP1_ENST00000493089.1_Silent_p.P42P	NM_001244810.1|NM_001244813.1|NM_032682.5	NP_001231739.1|NP_001231742.1|NP_116071.2	Q9H334	FOXP1_HUMAN	forkhead box P1	42					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		TGTCCACGGCCGGCGTCTCTC	0.632000			T	PAX5	ALL								22	128					0	0	1	0	0
LINC01359	101927084	broad.mit.edu	37	1	65451793	65451793	+	RNA	DEL	T	T	-	rs113756498		TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:65451793delT	ENST00000447748.1	-	0	1775																											AATCTAATTGttttttttttt	0.493													4	5	---	---	---	---					
MTR	4548	broad.mit.edu	37	1	237024474	237024474	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr1:237024474delA	ENST00000366577.5	+	20	2487	c.2093delA	c.(2092-2094)cafs	p.Q698fs	MTR_ENST00000535889.1_Intron	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase	698	B12-binding N-terminal.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	AGGTTAAACCAAAAAAAATAT	0.308													7	148	---	---	---	---					
DNAH1	25981	broad.mit.edu	37	3	52423601	52423602	+	Splice_Site	INS	-	-	G	rs138518792	by1000genomes	TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr3:52423601_52423602insG	ENST00000420323.2	+	60	9881_9882	c.9621_splice	c.e60+1	p.H3207_splice		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3272					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CGATCGTGGCAGGTGCCCACCC	0.658													2	4	---	---	---	---					
TALDO1	6888	broad.mit.edu	37	11	747521	747521	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr11:747521delG	ENST00000319006.3	+	1	193	c.40delG	c.(40-42)cgfs	p.A14fs	TALDO1_ENST00000528097.1_Frame_Shift_Del_p.A14fs			P37837	TALDO_HUMAN	transaldolase 1	14					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity			breast(1)|kidney(2)|large_intestine(5)|lung(4)|prostate(2)	14		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;4.66e-26)|Epithelial(43;2.97e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.48e-19)|BRCA - Breast invasive adenocarcinoma(625;4.41e-05)|Lung(200;0.0595)|LUSC - Lung squamous cell carcinoma(625;0.0712)		GATGGAGTCCGCGCTGGACCA	0.731													6	10	---	---	---	---					
PABPC3	5042	broad.mit.edu	37	13	25671804	25671806	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr13:25671804_25671806delGCT	ENST00000281589.3	+	1	1505_1507	c.1468_1470delGCT	c.(1468-1470)del	p.A496del		NM_030979.2	NP_112241.2	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	496					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|pancreas(1)|skin(3)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		ACGTCctgcagctgctgctgctg	0.532													11	79	---	---	---	---					
SPATA5L1	79029	broad.mit.edu	37	15	45710840	45710841	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr15:45710840_45710841insT	ENST00000305560.6	+	7	2153_2154	c.2054_2055insT	c.(2053-2055)tttfs	p.F685fs	SPATA5L1_ENST00000533841.1_3'UTR	NM_024063.2	NP_076968.2	Q9BVQ7	SPA5L_HUMAN	spermatogenesis associated 5-like 1	685						cytoplasm	ATP binding|nucleoside-triphosphatase activity			kidney(2)|large_intestine(3)|lung(1)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	14		Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;7.31e-17)|GBM - Glioblastoma multiforme(94;6.28e-07)		GCAGAAACCTGTTTTTTTTCTG	0.361													7	120	---	---	---	---					
MIR3648-1	100500862	broad.mit.edu	37	21	9825838	9825839	+	RNA	INS	-	-	GCG	rs3052281		TCGA-D9-A3Z3-06A-11D-A23B-08	TCGA-D9-A3Z3-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7ed76151-1367-4e41-870d-06816e6a107d	32a2eed0-1c50-4482-8479-c8278ba893ca	g.chr21:9825838_9825839insGCG	ENST00000581792.1	+	0	7_8					NR_037421.1																						cggccgcgactgcggcggcggt	0.842													3	6	---	---	---	---