Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
IDO2	169355	broad.mit.edu	37	8	39845428	39845428	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:39845428G>A	ENST00000502986.2	+	7	769	c.527G>A	c.(526-528)aGc>aAc	p.S176N	RP11-44K6.3_ENST00000517623.1_RNA|IDO2_ENST00000343295.4_3'UTR|IDO2_ENST00000389060.4_Missense_Mutation_p.S163N	NM_194294.2	NP_919270.2	Q6ZQW0	I23O2_HUMAN	indoleamine 2,3-dioxygenase 2	163					tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	18						GGGGGAGAGAGCCTGCATGGT	0.468000													5	10					0	0	1	0	0
RUNX2	860	broad.mit.edu	37	6	45390482	45390482	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:45390482C>G	ENST00000371438.1	+	2	569	c.211C>G	c.(211-213)Cag>Gag	p.Q71E	RUNX2_ENST00000371436.6_Missense_Mutation_p.Q71E|RUNX2_ENST00000371432.3_Missense_Mutation_p.Q57E|RUNX2_ENST00000352853.5_Missense_Mutation_p.Q139E|RUNX2_ENST00000576263.1_Missense_Mutation_p.Q71E|RUNX2_ENST00000359524.5_Missense_Mutation_p.Q57E|RUNX2_ENST00000465038.2_Missense_Mutation_p.Q71E|RUNX2_ENST00000541979.1_Missense_Mutation_p.Q139E	NM_001024630.3	NP_001019801.3	Q13950	RUNX2_HUMAN	runt-related transcription factor 2	71	Poly-Gln.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(18)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						gcagcagcagcaggaggcggc	0.716000													3	21					0	0	1	0	0
FEM1A	55527	broad.mit.edu	37	19	4793789	4793789	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:4793789C>T	ENST00000269856.3	+	1	2062	c.1923C>T	c.(1921-1923)tgC>tgT	p.C641C	AC005523.2_ENST00000601192.1_RNA	NM_018708.2	NP_061178.1	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a (C. elegans)	641					regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	17		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		CCCTGCAGTGCCTTGCGGCCC	0.592000													10	10					0	0	1	0	0
SERPINA3	12	broad.mit.edu	37	14	95081354	95081354	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:95081354C>T	ENST00000553947.1	+	5	1539	c.651C>T	c.(649-651)atC>atT	p.I217I	SERPINA3_ENST00000393078.3_Silent_p.I192I|SERPINA3_ENST00000467132.1_Silent_p.I192I|SERPINA3_ENST00000556388.1_Intron|SERPINA3_ENST00000393080.4_Silent_p.I192I			P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	192					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(17)|ovary(2)|pancreas(1)|skin(3)|stomach(1)	40		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		GGGGGAAAATCACAGATCTGA	0.493000													23	61					0	0	1	0	0
DPPA2	151871	broad.mit.edu	37	3	109028135	109028135	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:109028135T>G	ENST00000478945.1	-	4	470	c.224A>C	c.(223-225)aAa>aCa	p.K75T		NM_138815.3	NP_620170.3	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	75						nucleus	nucleic acid binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						GCATCTAGCTTTTTGTGGAGC	0.403000													21	40					0	0	1	0	0
MTM1	4534	broad.mit.edu	37	X	149831996	149831996	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:149831996C>T	ENST00000370396.2	+	14	1612	c.1558C>T	c.(1558-1560)Cga>Tga	p.R520*	MTM1_ENST00000543350.1_Nonsense_Mutation_p.R405*|MTM1_ENST00000542741.1_3'UTR|MTM1_ENST00000413012.2_Nonsense_Mutation_p.R483*|MTM1_ENST00000306167.7_3'UTR	NM_000252.2	NP_000243.1	Q13496	MTM1_HUMAN	myotubularin 1	520	Myotubularin phosphatase.				endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Acute lymphoblastic leukemia(192;6.56e-05)					AGAAATCAATCGAGTTTTATA	0.373000													25	5					0	0	1	0	0
GFM1	85476	broad.mit.edu	37	3	158362460	158362460	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:158362460G>A	ENST00000486715.1	+	1	394	c.37G>A	c.(37-39)Ggg>Agg	p.G13R	GFM1_ENST00000478576.1_Missense_Mutation_p.G13R|GFM1_ENST00000264263.5_Missense_Mutation_p.G13R	NM_024996.5	NP_079272.4	Q96RP9	EFGM_HUMAN	G elongation factor, mitochondrial 1	13					mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|urinary_tract(2)	22			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)			CGCGGCTCTGGGGCGCGGAAG	0.657000											OREG0015898	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	2					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33954796	33954796	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr15:33954796G>A	ENST00000389232.4	+	35	5135	c.5065G>A	c.(5065-5067)Gag>Aag	p.E1689K	RYR3_ENST00000415757.3_Missense_Mutation_p.E1689K	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1689	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GATTCCCTTGGAGAGTCTCAG	0.582000													51	8					0	0	1	0	0
ALAS1	211	broad.mit.edu	37	3	52245537	52245537	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:52245537C>T	ENST00000394965.2	+	10	1929	c.1569C>T	c.(1567-1569)gtC>gtT	p.V523V	ALAS1_ENST00000310271.2_Silent_p.V523V|ALAS1_ENST00000484952.1_Silent_p.V523V|ALAS1_ENST00000469224.1_Silent_p.V523V	NM_000688.5	NP_000679.1	P13196	HEM1_HUMAN	aminolevulinate, delta-, synthase 1	523					heme biosynthetic process	mitochondrial matrix	5-aminolevulinate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			endometrium(3)|kidney(3)|large_intestine(7)|liver(2)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	23				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	TCCCTGTTGTCCACTGCCCCA	0.582000													18	39					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1051561	1051561	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:1051561G>A	ENST00000263094.6	+	21	3169	c.2938G>A	c.(2938-2940)Gag>Aag	p.E980K	ABCA7_ENST00000435683.2_Missense_Mutation_p.E842K|ABCA7_ENST00000433129.1_Missense_Mutation_p.E980K	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	980	ABC transporter 1.				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGTATTTGGGAGCTGCTGCT	0.582000													18	12					0	0	1	0	0
IGFN1	91156	broad.mit.edu	37	1	201185596	201185596	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:201185596C>T	ENST00000335211.4	+	16	9440	c.9310C>T	c.(9310-9312)Cca>Tca	p.P3104S	IGFN1_ENST00000295591.8_Missense_Mutation_p.P264S	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						GCCTGATCCCCCACAAGGCCC	0.672000													26	10					0	0	1	0	0
ACOT7	11332	broad.mit.edu	37	1	6387469	6387469	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:6387469G>A	ENST00000361521.4	-	5	1506	c.515C>T	c.(514-516)tCc>tTc	p.S172F	ACOT7_ENST00000377845.3_Missense_Mutation_p.S152F|ACOT7_ENST00000541130.1_Missense_Mutation_p.S152F|ACOT7_ENST00000545482.1_Missense_Mutation_p.S67F|ACOT7_ENST00000377842.3_Missense_Mutation_p.S131F|ACOT7_ENST00000377855.2_Missense_Mutation_p.S182F	NM_007274.3	NP_009205.3	O00154	BACH_HUMAN	acyl-CoA thioesterase 7	182						mitochondrion|nucleus	carboxylesterase activity|fatty-acyl-CoA binding|palmitoyl-CoA hydrolase activity			kidney(1)|large_intestine(3)|lung(10)|pancreas(1)|prostate(1)	16	Ovarian(185;0.0634)|all_lung(157;0.175)	all_cancers(23;1.42e-38)|all_epithelial(116;3.96e-23)|all_lung(118;3.69e-08)|Lung NSC(185;8.52e-07)|all_hematologic(16;6.92e-06)|Colorectal(325;4.53e-05)|Acute lymphoblastic leukemia(12;5e-05)|all_neural(13;0.000164)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0393)|Medulloblastoma(700;0.211)		Epithelial(90;9.16e-37)|GBM - Glioblastoma multiforme(13;5.89e-29)|OV - Ovarian serous cystadenocarcinoma(86;7.63e-19)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;2.06e-05)|Kidney(185;7.74e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00129)|BRCA - Breast invasive adenocarcinoma(365;0.00132)|STAD - Stomach adenocarcinoma(132;0.00195)|READ - Rectum adenocarcinoma(331;0.0481)		CTCCTGCCGGGAATACTGCGA	0.627000													25	16					0	0	1	0	0
C2orf40	84417	broad.mit.edu	37	2	106690398	106690398	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:106690398C>T	ENST00000409944.1	+	4	307	c.76C>T	c.(76-78)Ctt>Ttt	p.L26F	C2orf40_ENST00000238044.3_Missense_Mutation_p.L62F|C2orf40_ENST00000489174.1_3'UTR			Q9H1Z8	AUGN_HUMAN	chromosome 2 open reading frame 40	62						extracellular region|transport vesicle				lung(7)|urinary_tract(1)	8						CAAAGAATTCCTTGGCAGCCT	0.517000													31	105					0	0	1	0	0
ABCA5	23461	broad.mit.edu	37	17	67297289	67297289	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:67297289C>T	ENST00000392676.3	-	9	1322	c.1258G>A	c.(1258-1260)Gtc>Atc	p.V420I	ABCA5_ENST00000588877.1_Missense_Mutation_p.V420I|ABCA5_ENST00000392677.2_Missense_Mutation_p.V420I			Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 5	420					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(18)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	54	Breast(10;3.72e-11)					CCTGGAATGACTTGATCAAGA	0.323000													50	18					0	0	1	0	0
RAB3GAP1	22930	broad.mit.edu	37	2	135911265	135911265	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:135911265C>T	ENST00000264158.8	+	19	2151	c.2108C>T	c.(2107-2109)tCa>tTa	p.S703L	RAB3GAP1_ENST00000487003.1_3'UTR|RAB3GAP1_ENST00000442034.1_Missense_Mutation_p.S703L|RAB3GAP1_ENST00000539493.1_Missense_Mutation_p.S659L|ZRANB3_ENST00000412849.1_Intron	NM_012233.2	NP_036365.1	Q15042	RB3GP_HUMAN	RAB3 GTPase activating protein subunit 1 (catalytic)	703						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32				BRCA - Breast invasive adenocarcinoma(221;0.117)		AGGTGGTATTCACCCCGGGAT	0.418000													23	65					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72832254	72832254	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:72832254C>T	ENST00000268489.5	-	9	4999	c.4327G>A	c.(4327-4329)Gct>Act	p.A1443T	ZFHX3_ENST00000397992.5_Missense_Mutation_p.A529T	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	1443					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				TTCTTCAGAGCCTGGAAAGTT	0.522000													52	74					0	0	1	0	0
UGGT1	56886	broad.mit.edu	37	2	128934408	128934408	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:128934408C>T	ENST00000375990.3	+	32	3891	c.3488C>T	c.(3487-3489)cCc>cTc	p.P1163L	UGGT1_ENST00000259253.6_Missense_Mutation_p.P1187L			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	1187					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						ACTGATTCTCCCCCTGATGCT	0.413000													116	44					0	0	1	0	0
TDRD9	122402	broad.mit.edu	37	14	104460925	104460925	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:104460925C>T	ENST00000409874.4	+	11	1353	c.1305C>T	c.(1303-1305)gtC>gtT	p.V435V	TDRD9_ENST00000339063.5_Silent_p.V435V	NM_153046.2	NP_694591.2	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	435	Helicase C-terminal.				cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				TAAGTCCAGTCCCTGGGTACA	0.358000													12	8					0	0	1	0	0
HNMT	3176	broad.mit.edu	37	2	138759672	138759672	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:138759672T>C	ENST00000280097.3	+	4	519	c.337T>C	c.(337-339)Ttt>Ctt	p.F113L	HNMT_ENST00000410115.1_Missense_Mutation_p.F113L|HNMT_ENST00000485653.1_3'UTR	NM_006895.2	NP_008826.1	P50135	HNMT_HUMAN	histamine N-methyltransferase	113					respiratory gaseous exchange	cytoplasm	histamine N-methyltransferase activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.125)	Amodiaquine(DB00613)|Histamine Phosphate(DB00667)|Quinacrine(DB01103)	GAACGTAAAGTTTGCTTGGCA	0.373000													6	34					0	0	1	0	0
CTRL	1506	broad.mit.edu	37	16	67964466	67964466	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:67964466G>A	ENST00000574481.1	-	5	905	c.344C>T	c.(343-345)tCt>tTt	p.S115F		NM_001907.2	NP_001898.1	P40313	CTRL_HUMAN	chymotrypsin-like	115	Peptidase S1.				digestion|proteolysis	extracellular space	serine-type endopeptidase activity			kidney(1)|large_intestine(2)|urinary_tract(1)	4		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)		CATGGTGGTAGAGTTCCAGCT	0.562000													73	79					0	0	1	0	0
ZP3	7784	broad.mit.edu	37	7	76062288	76062288	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:76062288C>T	ENST00000336517.4	+	4	669	c.323C>T	c.(322-324)cCc>cTc	p.P108L	ZP3_ENST00000394857.3_Missense_Mutation_p.P159L|ZP3_ENST00000416245.1_5'UTR	NM_007155.5	NP_009086.4	P21754	ZP3_HUMAN	zona pellucida glycoprotein 3 (sperm receptor)	159	ZP.				binding of sperm to zona pellucida|blastocyst formation|egg coat formation|humoral immune response mediated by circulating immunoglobulin|intracellular protein transport|negative regulation of binding of sperm to zona pellucida|negative regulation of transcription, DNA-dependent|oocyte development|phosphatidylinositol-mediated signaling|positive regulation of acrosomal vesicle exocytosis|positive regulation of acrosome reaction|positive regulation of antral ovarian follicle growth|positive regulation of calcium ion import|positive regulation of calcium ion transport via store-operated calcium channel activity|positive regulation of humoral immune response|positive regulation of interferon-gamma production|positive regulation of interleukin-4 production|positive regulation of leukocyte migration|positive regulation of ovarian follicle development|positive regulation of phosphatidylinositol biosynthetic process|positive regulation of protein kinase activity|positive regulation of protein kinase B signaling cascade|positive regulation of T cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of type IV hypersensitivity|protein kinase C signaling cascade	endoplasmic reticulum|extracellular space|Golgi apparatus|integral to membrane|multivesicular body|outer acrosomal membrane|perinuclear region of cytoplasm|plasma membrane|proteinaceous extracellular matrix	acrosin binding|manganese ion transmembrane transporter activity|receptor activity|sugar binding			endometrium(1)|large_intestine(3)|lung(2)|skin(1)	7						ACCTGGTTGCCCTTCAGGACC	0.587000													13	13					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40354371	40354371	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:40354371C>T	ENST00000221347.6	-	35	16105	c.16098G>A	c.(16096-16098)ggG>ggA	p.G5366G		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	5366	VWFD 13.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CACACAGTTTCCCAGCATGGT	0.577000													5	21					0	0	1	0	0
C8orf46	254778	broad.mit.edu	37	8	67417683	67417683	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:67417683C>T	ENST00000305454.3	+	3	641	c.200C>T	c.(199-201)cCt>cTt	p.P67L	C8orf46_ENST00000482608.2_3'UTR|C8orf46_ENST00000521495.1_Missense_Mutation_p.P67L|C8orf46_ENST00000480005.1_Missense_Mutation_p.P67L|C8orf46_ENST00000522977.1_Missense_Mutation_p.P67L	NM_152765.3	NP_689978.2	Q8TAG6	CH046_HUMAN	chromosome 8 open reading frame 46	67										endometrium(1)|large_intestine(1)|lung(1)|prostate(1)|skin(2)	6			Epithelial(68;0.0224)|BRCA - Breast invasive adenocarcinoma(89;0.0508)|all cancers(69;0.0558)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			CGCAGGGACCCTGGCGACCGC	0.731000													7	8					0	0	1	0	0
GPD1L	23171	broad.mit.edu	37	3	32181842	32181842	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:32181842C>T	ENST00000282541.5	+	4	690	c.489C>T	c.(487-489)ttC>ttT	p.F163F		NM_015141.3	NP_055956.1	Q8N335	GPD1L_HUMAN	glycerol-3-phosphate dehydrogenase 1-like	163					glycerol-3-phosphate catabolic process	glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|NAD binding|protein homodimerization activity			large_intestine(4)|lung(7)|ovary(1)	12						CAGAGAAGTTCTGTGAGACCA	0.473000													15	44					0	0	1	0	0
DGKG	1608	broad.mit.edu	37	3	186015887	186015887	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:186015887C>T	ENST00000265022.3	-	4	815	c.276G>A	c.(274-276)acG>acA	p.T92T	DGKG_ENST00000382164.4_Silent_p.T92T|DGKG_ENST00000344484.4_Silent_p.T92T|DGKG_ENST00000544847.1_Silent_p.T92T	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	92					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	TGGCTCCCTCCGTCGGGTGGT	0.617000													38	27					0	0	1	0	0
SERPING1	710	broad.mit.edu	37	11	57381809	57381809	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:57381809G>A	ENST00000403558.1	+	7	1753	c.1387G>A	c.(1387-1389)Gat>Aat	p.D463N	SERPING1_ENST00000278407.4_Missense_Mutation_p.D420N|SERPING1_ENST00000378323.4_Missense_Mutation_p.D425N|SERPING1_ENST00000378324.2_Missense_Mutation_p.D368N|SERPING1_ENST00000340687.6_Missense_Mutation_p.D383N	NM_001032295.1	NP_001027466.1	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	420					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(11)|pancreas(2)|prostate(1)|urinary_tract(1)	27						AGAATTCTTCGATTTTTCTTA	0.483000													50	44					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5410232	5410232	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:5410232G>A	ENST00000399537.4	-	11	4341	c.3993C>T	c.(3991-3993)ttC>ttT	p.F1331F	TNRC18_ENST00000430969.1_Silent_p.F1331F			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1331							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		GACTGGGCAGGAACTGGTCAG	0.701000													7	13					0	0	1	0	0
OR8B2	26595	broad.mit.edu	37	11	124253153	124253153	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:124253153G>A	ENST00000375013.2	-	1	105	c.87C>T	c.(85-87)ttC>ttT	p.F29F		NM_001005468.1	NP_001005468.1	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B, member 2	29					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(13)|ovary(1)	23		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		CTAGAAACAGGAAAAAGAGGG	0.413000													19	85					0	0	1	0	0
SERPINA4	5267	broad.mit.edu	37	14	95030284	95030284	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:95030284C>T	ENST00000557004.1	+	2	886	c.465C>T	c.(463-465)ttC>ttT	p.F155F	SERPINA5_ENST00000553780.1_Intron|SERPINA4_ENST00000298841.5_Silent_p.F155F|SERPINA4_ENST00000555095.1_Silent_p.F155F			P29622	KAIN_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	155					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(28)|ovary(3)|skin(1)|urinary_tract(1)	46				COAD - Colon adenocarcinoma(157;0.211)		TTGCAAAATTCCTGAATGACA	0.537000													22	71					0	0	1	0	0
PVRL1	5818	broad.mit.edu	37	11	119509512	119509512	+	Missense_Mutation	SNP	C	C	T	rs143612966	byFrequency	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:119509512C>T	ENST00000341398.2	-	7	1155	c.1156G>A	c.(1156-1158)Gac>Aac	p.D386N	RP11-196E1.3_ENST00000532153.1_RNA|RP11-196E1.3_ENST00000601999.1_RNA	NM_203285.1	NP_976030.1	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 (herpesvirus entry mediator C)	0					adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		AGGGGCTGGTCGGTCCTGGAG	0.627000													8	11					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16893772	16893772	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:16893772G>A	ENST00000430580.2	-	25	3628	c.2741C>T	c.(2740-2742)cCt>cTt	p.P914L	NBPF1_ENST00000432949.1_3'UTR|NBPF1_ENST00000420031.2_3'UTR	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	914	NBPF 5.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		ATAACCTGAAGGAGTTGAATA	0.483000													84	1065					0	0	1	0	0
NOMO1	23420	broad.mit.edu	37	16	14947797	14947797	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:14947797C>T	ENST00000287667.7	+	9	1048	c.877C>T	c.(877-879)Ccg>Tcg	p.P293S	NOMO1_ENST00000566883.1_3'UTR	NM_014287.3	NP_055102.3	Q15155	NOMO1_HUMAN	NODAL modulator 1	293						integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			endometrium(6)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|skin(2)	30						CTTCCAGATTCCGTTCTATCG	0.438000													43	68					0	0	1	0	0
CD300LF	146722	broad.mit.edu	37	17	72699274	72699274	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:72699274G>A	ENST00000361254.4	-	3	399	c.400C>T	c.(400-402)Cct>Tct	p.P134S	CD300LF_ENST00000464910.1_Intron|RAB37_ENST00000340415.3_Intron|RAB37_ENST00000402449.4_Intron|CD300LF_ENST00000326165.6_Intron|CD300LF_ENST00000343125.4_Intron|CD300LF_ENST00000301573.9_Intron|CD300LF_ENST00000583937.1_Missense_Mutation_p.P131S|CD300LF_ENST00000469092.1_Intron|CD300LF_ENST00000581500.1_Missense_Mutation_p.P134S			Q8TDQ1	CLM1_HUMAN	CD300 molecule-like family member f	127						integral to membrane|plasma membrane	receptor activity			endometrium(2)|large_intestine(1)|lung(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						GTGGGGGCAGGAGTCGACGCT	0.592000													28	4					0	0	1	0	0
MLST8	64223	broad.mit.edu	37	16	2256079	2256079	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:2256079G>A	ENST00000301725.7	+	2	50	c.50G>A	c.(49-51)gGc>gAc	p.G17D	MLST8_ENST00000569417.1_5'UTR|MLST8_ENST00000382450.4_5'UTR|MLST8_ENST00000564088.1_5'UTR|MLST8_ENST00000301724.10_5'UTR|MLST8_ENST00000561651.1_3'UTR|MLST8_ENST00000397124.1_5'UTR|MLST8_ENST00000565250.1_5'UTR			Q9BVC4	LST8_HUMAN	MTOR associated protein, LST8 homolog (S. cerevisiae)	274					insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|T cell costimulation	cytosol	protein binding			large_intestine(3)|lung(2)|skin(1)	6						GCCCGTGCAGGCCACACCATG	0.592000													83	87					0	0	1	0	0
GRIN2D	2906	broad.mit.edu	37	19	48925101	48925101	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:48925101C>T	ENST00000263269.3	+	10	2239	c.2151C>T	c.(2149-2151)tcC>tcT	p.S717S		NM_000836.2	NP_000827.2	O15399	NMDE4_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	717						cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			autonomic_ganglia(1)|breast(6)|endometrium(2)|large_intestine(9)|lung(12)|ovary(5)|pancreas(1)|prostate(1)	37		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	CCAACGGCTCCACGGAGAAGA	0.622000													44	40					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	211192138	211192138	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:211192138C>T	ENST00000271751.4	-	6	1046	c.1019G>A	c.(1018-1020)gGg>gAg	p.G340E	KCNH1_ENST00000367007.4_Intron			O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	340					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		ACTCTCTCTCCCCTCCAGTGG	0.438000													62	21					0	0	1	0	0
FMO5	2330	broad.mit.edu	37	1	146672834	146672834	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:146672834C>T	ENST00000254090.4	-	7	1471	c.1083G>A	c.(1081-1083)ctG>ctA	p.L361L	FMO5_ENST00000441068.2_Silent_p.L361L|RP11-337C18.8_ENST00000607149.1_RNA|FMO5_ENST00000369272.3_Intron	NM_001461.2	NP_001452.2	P49326	FMO5_HUMAN	flavin containing monooxygenase 5	361						integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(9)|ovary(3)|upper_aerodigestive_tract(1)	25	all_hematologic(923;0.0487)					TTGGCCTTTCCAGGTTAGGAG	0.458000													8	75					0	0	1	0	0
NOA1	84273	broad.mit.edu	37	4	57840144	57840144	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:57840144G>A	ENST00000264230.4	-	2	2426	c.1189C>T	c.(1189-1191)Cct>Tct	p.P397S		NM_032313.2	NP_115689.1	Q8NC60	CD014_HUMAN	nitric oxide associated 1	397							GTP binding										ATTCTGTAAGGAGTTGGGTTG	0.338000													9	35					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15854450	15854450	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:15854450G>A	ENST00000338282.6	-	11	1301	c.1195C>T	c.(1195-1197)Cct>Tct	p.P399S	MYH11_ENST00000576790.1_Missense_Mutation_p.P399S|MYH11_ENST00000396324.3_Missense_Mutation_p.P406S|MYH11_ENST00000452625.2_Missense_Mutation_p.P406S|MYH11_ENST00000300036.5_Missense_Mutation_p.P399S	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	399	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						TTGATACGAGGAGTGAGGATG	0.453000			T	CBFB	AML								60	82					0	0	1	0	0
TPSG1	25823	broad.mit.edu	37	16	1272655	1272655	+	Missense_Mutation	SNP	C	C	T	rs117769620	byFrequency	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:1272655C>T	ENST00000234798.4	-	4	512	c.508G>A	c.(508-510)Gga>Aga	p.G170R		NM_012467.3	NP_036599.3	Q9NRR2	TRYG1_HUMAN	tryptase gamma 1	170	Peptidase S1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			liver(1)|lung(2)|skin(1)	4		Hepatocellular(780;0.00369)				TCCTCACCTCCCTCCCGCGTA	0.667000													77	103					0	0	1	0	0
POTEA	340441	broad.mit.edu	37	8	43197399	43197399	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:43197399G>A	ENST00000522175.2	+	0	1152							Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(27)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						AGCGTCAGAGGATTATGATTT	0.358000													22	39					0	0	1	0	0
ADAM15	8751	broad.mit.edu	37	1	155030485	155030485	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:155030485C>T	ENST00000356955.2	+	14	1676	c.1575C>T	c.(1573-1575)gcC>gcT	p.A525A	ADAM15_ENST00000271836.6_Silent_p.A525A|ADAM15_ENST00000368412.3_Silent_p.A525A|ADAM15_ENST00000368410.2_Silent_p.A231A|ADAM15_ENST00000360674.4_Silent_p.A525A|ADAM15_ENST00000447332.3_Silent_p.A509A|ADAM15_ENST00000449910.2_Silent_p.A525A|ADAM15_ENST00000368413.1_Silent_p.A231A|ADAM15_ENST00000359280.4_Silent_p.A525A|ADAM15_ENST00000472434.1_3'UTR|ADAM15_ENST00000531455.1_Silent_p.A535A|ADAM15_ENST00000355956.2_Silent_p.A525A	NM_207197.2	NP_997080.1	Q13444	ADA15_HUMAN	ADAM metallopeptidase domain 15	525	Cys-rich.				angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(5)|urinary_tract(1)	39	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			GGCGTTGTGCCTCCTATGCCC	0.632000													59	24					0	0	1	0	0
USP9X	8239	broad.mit.edu	37	X	41045827	41045827	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:41045827C>T	ENST00000324545.7	+	24	4249	c.3616C>T	c.(3616-3618)Cct>Tct	p.P1206S	USP9X_ENST00000378308.2_Missense_Mutation_p.P1206S	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	1206					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						TCAGAGCATTCCTAATCCATC	0.378000													37	9					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166911171	166911171	+	Silent	SNP	G	G	A	rs116478064	by1000genomes	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:166911171G>A	ENST00000423058.2	-	4	596	c.579C>T	c.(577-579)ctC>ctT	p.L193L	SCN1A_ENST00000303395.4_Silent_p.L193L|SCN1A_ENST00000375405.3_Silent_p.L193L|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Silent_p.L193L|AC010127.3_ENST00000599041.1_RNA|AC010127.3_ENST00000595268.1_RNA	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	193						voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.L193L(1)		NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CAGTGAAATCGAGCCAGTTCC	0.343000													20	13					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94693338	94693338	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:94693338C>T	ENST00000282020.4	+	16	2971	c.2713C>T	c.(2713-2715)Ctg>Ttg	p.L905L	GRID2_ENST00000510992.1_Silent_p.L810L	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	905					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TTTGACCCCTCTGGACATTGA	0.458000													19	56					0	0	1	0	0
IKBKAP	8518	broad.mit.edu	37	9	111653612	111653612	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:111653612G>A	ENST00000374647.5	-	28	3338	c.3031C>T	c.(3031-3033)Cgt>Tgt	p.R1011C	IKBKAP_ENST00000537196.1_Missense_Mutation_p.R662C	NM_003640.3	NP_003631.2	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	1011					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			NS(2)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						GCACCGCAACGGGCAAACATG	0.532000													19	44					0	0	1	0	0
ERG	2078	broad.mit.edu	37	21	39817371	39817371	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr21:39817371G>A	ENST00000442448.1	-	4	484	c.213C>T	c.(211-213)gtC>gtT	p.V71V	ERG_ENST00000398897.1_Intron|ERG_ENST00000453032.2_Intron|ERG_ENST00000398905.1_Silent_p.V64V|ERG_ENST00000429727.2_Silent_p.V64V|ERG_ENST00000398911.1_Silent_p.V71V|ERG_ENST00000398919.2_Silent_p.V71V|ERG_ENST00000288319.7_Silent_p.V64V|ERG_ENST00000398907.1_Silent_p.V64V|ERG_ENST00000398910.1_Silent_p.V71V|ERG_ENST00000417133.2_Silent_p.V71V	NM_004449.4	NP_004440.1	P11308	ERG_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog	71					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		EWSR1/ERG(178)|NDRG1/ERG(5)|TMPRSS2/ERG(3582)|FUS/ERG(167)|SLC45A3/ERG(50)	lung(2)|ovary(1)|skin(1)	4		Prostate(19;3.6e-06)				TTTTGATGGTGACCCTGGCTG	0.552000			T	"""EWSR1, TMPRSS2, ELF4, FUS, HERPUD1, NDRG1"""	"""Ewing sarcoma, prostate, AML"""								12	11					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41551602	41551602	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:41551602C>T	ENST00000396942.1	-	29	3429	c.3346G>A	c.(3346-3348)Gag>Aag	p.E1116K	ANK1_ENST00000352337.4_Missense_Mutation_p.E1116K|ANK1_ENST00000379758.2_Missense_Mutation_p.E1116K|ANK1_ENST00000289734.7_Missense_Mutation_p.E1116K|ANK1_ENST00000265709.8_Missense_Mutation_p.E1157K|ANK1_ENST00000396945.1_Missense_Mutation_p.E1116K|ANK1_ENST00000347528.4_Missense_Mutation_p.E1116K			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1116					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GTGACAAGCTCATCCGGGACA	0.627000													12	30					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48753756	48753756	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:48753756C>T	ENST00000285238.8	+	23	3265	c.3185C>T	c.(3184-3186)aCc>aTc	p.T1062I		NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	1062	ABC transmembrane type-1 2.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	TTCTTTGACACCACACCATCA	0.567000													83	24					0	0	1	0	0
COMMD5	28991	broad.mit.edu	37	8	146076258	146076258	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:146076258G>A	ENST00000450361.2	-	2	887	c.466C>T	c.(466-468)Cgg>Tgg	p.R156W	COMMD5_ENST00000305103.3_Missense_Mutation_p.R156W|COMMD5_ENST00000402718.3_Missense_Mutation_p.R156W	NM_001081003.1	NP_001074472.1	Q9GZQ3	COMD5_HUMAN	COMM domain containing 5	156	COMM.					nucleus	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|ovary(1)|pancreas(1)	11	all_cancers(97;1.14e-11)|all_epithelial(106;7.74e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)			ACCCGCCACCGAAAGTCAGCA	0.637000													9	13					0	0	1	0	0
SERPINI2	5276	broad.mit.edu	37	3	167170763	167170763	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:167170763C>G	ENST00000476257.1	-	7	1223	c.925G>C	c.(925-927)Gag>Cag	p.E309Q	SERPINI2_ENST00000471111.1_Missense_Mutation_p.E309Q|SERPINI2_ENST00000461846.1_Missense_Mutation_p.E309Q|SERPINI2_ENST00000264677.4_Missense_Mutation_p.E309Q			O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin), member 2	309					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(20)|prostate(1)|skin(5)|urinary_tract(1)	41						CTAAATATCTCGGTTATGTTC	0.279000													9	13					0	0	1	0	0
PADI1	29943	broad.mit.edu	37	1	17570710	17570710	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:17570710C>T	ENST00000375471.4	+	16	2056	c.1964C>T	c.(1963-1965)cCc>cTc	p.P655L	PADI1_ENST00000536552.1_Missense_Mutation_p.P126L|PADI1_ENST00000460293.1_3'UTR|PADI1_ENST00000413717.2_Missense_Mutation_p.P170L|PADI1_ENST00000537499.1_Missense_Mutation_p.P212L	NM_013358.2	NP_037490.2	Q9ULC6	PADI1_HUMAN	peptidyl arginine deiminase, type I	655					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	28		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00522)|BRCA - Breast invasive adenocarcinoma(304;1.3e-05)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(196;0.0069)|READ - Rectum adenocarcinoma(331;0.0681)|Lung(427;0.197)	L-Citrulline(DB00155)	AAGCCCTTTCCCTTCAAATGG	0.597000													73	17					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10545580	10545580	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:10545580G>A	ENST00000583535.1	-	17	2023	c.1936C>T	c.(1936-1938)Caa>Taa	p.Q646*	MYH3_ENST00000226209.7_Nonsense_Mutation_p.Q646*	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	646	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						GAGACAGTTTGGAAGGAAGAA	0.383000													12	10					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64375232	64375232	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:64375232G>A	ENST00000265459.6	-	23	5036	c.4575C>T	c.(4573-4575)acC>acT	p.T1525T	NRXN2_ENST00000377551.1_Silent_p.T1525T|NRXN2_ENST00000409571.1_Silent_p.T1518T|NRXN2_ENST00000377559.3_Silent_p.T1455T|NRXN2_ENST00000301894.2_Silent_p.T479T	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	1525					cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						GTGACAGGAGGGTGGTGCGGT	0.706000													3	2					0	0	1	0	0
MICALL1	85377	broad.mit.edu	37	22	38318090	38318090	+	Silent	SNP	G	G	A	rs144508698		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:38318090G>A	ENST00000215957.6	+	6	807	c.681G>A	c.(679-681)tcG>tcA	p.S227S		NM_033386.3	NP_203744.1	Q8N3F8	MILK1_HUMAN	MICAL-like 1	227						cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	24	Melanoma(58;0.045)					GGACACGGTCGGGGACCAGGC	0.647000													22	46					0	0	1	0	0
FLRT3	23767	broad.mit.edu	37	20	14307759	14307759	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:14307759C>T	ENST00000378053.3	-	2	650	c.394G>A	c.(394-396)Gaa>Aaa	p.E132K	MACROD2_ENST00000217246.4_Intron|MACROD2_ENST00000310348.4_Intron|FLRT3_ENST00000341420.4_Missense_Mutation_p.E132K	NM_013281.3	NP_037413.1	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	132					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		AAATGTAATTCTTCCAGATAG	0.388000													87	47					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	69703821	69703821	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:69703821G>A	ENST00000370598.1	+	11	2717	c.1896G>A	c.(1894-1896)agG>agA	p.R632R		NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	632					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				CATTTAAAAGGGCAAGTTACA	0.443000													14	53					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47566585	47566585	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr18:47566585G>A	ENST00000285039.7	-	3	537	c.238C>T	c.(238-240)Ctt>Ttt	p.L80F		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	80	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		GGCTCATGAAGATAGCTAAGG	0.468000													105	122					0	0	1	0	0
MARCH6	10299	broad.mit.edu	37	5	10403570	10403570	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:10403570C>T	ENST00000274140.5	+	15	1381	c.1249C>T	c.(1249-1251)Cca>Tca	p.P417S	MARCH6_ENST00000510792.1_Missense_Mutation_p.P115S|MARCH6_ENST00000503788.1_Missense_Mutation_p.P312S|MARCH6_ENST00000449913.2_Missense_Mutation_p.P369S	NM_005885.2	NP_005876.2	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase	417					protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(35)|ovary(1)|urinary_tract(3)	54						TCAGTCGGCTCCAGGTACTAC	0.448000													50	13					0	0	1	0	0
GRIN2D	2906	broad.mit.edu	37	19	48925100	48925100	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:48925100C>T	ENST00000263269.3	+	10	2238	c.2150C>T	c.(2149-2151)tCc>tTc	p.S717F		NM_000836.2	NP_000827.2	O15399	NMDE4_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	717						cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			autonomic_ganglia(1)|breast(6)|endometrium(2)|large_intestine(9)|lung(12)|ovary(5)|pancreas(1)|prostate(1)	37		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	CCCAACGGCTCCACGGAGAAG	0.617000													45	40					0	0	1	0	0
LPIN1	23175	broad.mit.edu	37	2	11943102	11943102	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:11943102C>T	ENST00000256720.2	+	14	1941	c.1848C>T	c.(1846-1848)ctC>ctT	p.L616L	LPIN1_ENST00000396099.1_Silent_p.L658L|LPIN1_ENST00000404113.2_Silent_p.L117L|LPIN1_ENST00000425416.2_Silent_p.L622L|LPIN1_ENST00000396097.1_Silent_p.L346L|LPIN1_ENST00000449576.2_Silent_p.L701L	NM_145693.2	NP_663731.1	Q14693	LPIN1_HUMAN	lipin 1	616					fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(15)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	45	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		CAGGCCACCTCCCTCTTCTGC	0.537000													33	163					0	0	1	0	0
DGCR14	8220	broad.mit.edu	37	22	19125788	19125788	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:19125788G>A	ENST00000252137.6	-	7	908	c.865C>T	c.(865-867)Ccc>Tcc	p.P289S		NM_022719.2	NP_073210.1	Q96DF8	DGC14_HUMAN	DiGeorge syndrome critical region gene 14	289					nervous system development	catalytic step 2 spliceosome				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)	16	Colorectal(54;0.0993)					GACTCCTGGGGGATCAGCTCC	0.627000													19	28					0	0	1	0	0
DDX20	11218	broad.mit.edu	37	1	112309187	112309187	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:112309187C>T	ENST00000475700.1	+	3	3323	c.965C>T	c.(964-966)tCa>tTa	p.S322L	DDX20_ENST00000369702.4_Missense_Mutation_p.S714L			Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	714	Helicase C-terminal.				assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			endometrium(3)|kidney(7)|large_intestine(6)|lung(3)|pancreas(1)|prostate(1)	21		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TATCAAGAATCACCTGGAATC	0.483000													34	76					0	0	1	0	0
MYH9	4627	broad.mit.edu	37	22	36684956	36684956	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:36684956G>A	ENST00000216181.5	-	33	4817	c.4587C>T	c.(4585-4587)gcC>gcT	p.A1529A		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	1529					actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						GCTGCTCTAGGGCCCGCTTGG	0.632000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				32	59					0	0	1	0	0
NEK10	152110	broad.mit.edu	37	3	27216271	27216271	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:27216271C>T	ENST00000429845.2	-	28	2921	c.2559G>A	c.(2557-2559)ctG>ctA	p.L853L	NEK10_ENST00000295720.6_Silent_p.L165L|NEK10_ENST00000357467.2_Silent_p.L250L|NEK10_ENST00000383771.4_Silent_p.L165L|NEK10_ENST00000383770.3_Silent_p.L165L|NEK10_ENST00000498182.1_5'UTR			Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10	853							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						GTTCACTTTTCAGGCTGGCTG	0.498000													51	39					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058218	11058218	+	RNA	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr21:11058218C>T	ENST00000470054.1	-	0	429									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGACTGAAATCCTGAAAGGTG	0.413000													15	56					0	0	1	0	0
FRMD1	79981	broad.mit.edu	37	6	168464329	168464329	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:168464329C>T	ENST00000283309.6	-	6	820	c.756G>A	c.(754-756)gaG>gaA	p.E252E	FRMD1_ENST00000432403.1_5'UTR|FRMD1_ENST00000440994.2_Silent_p.E184E|FRMD1_ENST00000537786.1_Silent_p.E23E	NM_024919.3	NP_079195.3	Q8N878	FRMD1_HUMAN	FERM domain containing 1	252	FERM.					cytoskeleton	binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|urinary_tract(1)	19		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		GCCGGCAGGCCTCCTGGATGA	0.662000													12	25					0	0	1	0	0
IGDCC3	9543	broad.mit.edu	37	15	65627166	65627166	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr15:65627166G>A	ENST00000327987.4	-	5	974	c.723C>T	c.(721-723)ctC>ctT	p.L241L		NM_004884.3	NP_004875.2	Q8IVU1	IGDC3_HUMAN	immunoglobulin superfamily, DCC subclass, member 3	241	Ig-like C2-type 3.									breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(9)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CAGGCCCCACGAGGATGGCTG	0.657000													16	3					0	0	1	0	0
GPR180	160897	broad.mit.edu	37	13	95264595	95264595	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:95264595C>T	ENST00000376958.4	+	3	481	c.456C>T	c.(454-456)aaC>aaT	p.N152N		NM_180989.5	NP_851320.1	Q86V85	GP180_HUMAN	G protein-coupled receptor 180	152						integral to membrane				breast(1)|kidney(1)|large_intestine(3)|lung(4)|urinary_tract(1)	10	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					TGTTACTAAACCCAGATGCCG	0.368000													30	22					0	0	1	0	0
CS	1431	broad.mit.edu	37	12	56676659	56676659	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:56676659G>A	ENST00000548567.1	-	6	656	c.186C>T	c.(184-186)atC>atT	p.I62I	CS_ENST00000351328.3_Silent_p.I128I|CS_ENST00000542324.2_Silent_p.I115I			O75390	CISY_HUMAN	citrate synthase	128					cellular carbohydrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	citrate (Si)-synthase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	17		Myeloproliferative disorder(1001;0.000374)		BRCA - Breast invasive adenocarcinoma(357;6.17e-07)		CCTCTGTTGGGATATGTCCAG	0.473000													24	37					0	0	1	0	0
SNORD113-4	767564	broad.mit.edu	37	14	101402864	101402864	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:101402864G>A	ENST00000364802.1	+	0	37					NR_003232.1																						ATCTGAAACAGGATTTTTGAT	0.348000													16	51					0	0	1	0	0
MAPK8IP3	23162	broad.mit.edu	37	16	1813667	1813667	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:1813667G>A	ENST00000250894.4	+	17	2062	c.1905G>A	c.(1903-1905)acG>acA	p.T635T	MAPK8IP3_ENST00000356010.5_Silent_p.T629T	NM_015133.3	NP_055948.2	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting protein 3	635					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(3)	42						GCGACTGCACGTCCTCCGCCC	0.672000													8	6					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216248207	216248207	+	Splice_Site	SNP	C	C	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:216248207C>A	ENST00000354785.4	-	31	5264		c.e31-1		FN1_ENST00000421182.1_Splice_Site|FN1_ENST00000357867.4_Splice_Site|FN1_ENST00000357009.2_Splice_Site|FN1_ENST00000356005.4_Splice_Site|FN1_ENST00000345488.5_Splice_Site|FN1_ENST00000336916.4_Splice_Site|FN1_ENST00000323926.6_Splice_Site|FN1_ENST00000446046.1_Splice_Site|FN1_ENST00000443816.1_Splice_Site|FN1_ENST00000346544.3_Splice_Site|FN1_ENST00000432072.2_Splice_Site|FN1_ENST00000359671.1_Splice_Site			P02751	FINC_HUMAN	fibronectin 1						acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTGTCAATTTCTACAAATAAA	0.463000													36	25					6.05902e-23	6.16918e-23	1	1	0
NRAS	4893	broad.mit.edu	37	1	115256530	115256530	+	Missense_Mutation	SNP	G	G	T	rs121913254		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:115256530G>T	ENST00000369535.4	-	3	434	c.181C>A	c.(181-183)Caa>Aaa	p.Q61K		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61K(595)|p.Q61E(9)|p.Q61L(3)|p.Q61R(2)|p.G60>?(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TACTCTTCTTGTCCAGCTGTA	0.458000	Q61K(CHP212_AUTONOMIC_GANGLIA)|Q61K(HCC15_LUNG)|Q61K(HS936T_SKIN)|Q61K(HS944T_SKIN)|Q61K(HT1080_SOFT_TISSUE)|Q61K(HUT78_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(M07E_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(NCIH1299_LUNG)|Q61K(NCIH2087_LUNG)|Q61K(OCILY19_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(SKNAS_AUTONOMIC_GANGLIA)|Q61K(SKNSH_AUTONOMIC_GANGLIA)|Q61K(TYKNU_OVARY)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			144	31					4.52276e-68	4.62339e-68	1	1	0
HELQ	113510	broad.mit.edu	37	4	84368028	84368028	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:84368028G>A	ENST00000295488.3	-	4	1514	c.1352C>T	c.(1351-1353)aCt>aTt	p.T451I	HELQ_ENST00000510985.1_Intron	NM_133636.2	NP_598375.2	Q8TDG4	HELQ_HUMAN	helicase, POLQ-like	451	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(17)|ovary(2)|skin(2)	38						AATTCTTCCAGTTTCAATCAA	0.328000								Other identified genes with known or suspected DNA repair function					26	54					0	0	1	0	0
LRRC32	2615	broad.mit.edu	37	11	76371451	76371451	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:76371451T>C	ENST00000407242.2	-	3	1428	c.1186A>G	c.(1186-1188)Aat>Gat	p.N396D	LRRC32_ENST00000404995.1_Missense_Mutation_p.N396D|LRRC32_ENST00000464145.1_Intron|LRRC32_ENST00000260061.5_Missense_Mutation_p.N396D|AP001189.4_ENST00000447519.1_RNA	NM_005512.2	NP_005503.1	Q14392	LRC32_HUMAN	leucine rich repeat containing 32	396						integral to plasma membrane				endometrium(1)|large_intestine(3)|lung(26)|upper_aerodigestive_tract(1)	31						CGCAGGGCATTGCCCTGTAGG	0.652000													12	11					0	0	1	0	0
TTLL5	23093	broad.mit.edu	37	14	76349196	76349196	+	Missense_Mutation	SNP	C	C	T	rs11844617		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:76349196C>T	ENST00000298832.9	+	30	3896	c.3691C>T	c.(3691-3693)Ccc>Tcc	p.P1231S	TTLL5_ENST00000556893.1_Missense_Mutation_p.P782S|TTLL5_ENST00000554510.1_Missense_Mutation_p.P740S|TTLL5_ENST00000557636.1_Missense_Mutation_p.P1246S	NM_015072.4	NP_055887.3	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	1231			P -> T (in dbSNP:rs11844617).		protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			NS(2)|breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(3)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	50				BRCA - Breast invasive adenocarcinoma(234;0.029)		CAAACCCCCACCCAACCACGA	0.473000													16	59					0	0	1	0	0
VSIG2	23584	broad.mit.edu	37	11	124622007	124622007	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:124622007G>A	ENST00000403470.1	-	1	82	c.27C>T	c.(25-27)ctC>ctT	p.L9L	VSIG2_ENST00000326621.5_Silent_p.L9L			Q96IQ7	VSIG2_HUMAN	V-set and immunoglobulin domain containing 2	9						integral to plasma membrane|membrane fraction				central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(5)	19	all_hematologic(175;0.215)	Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0215)		GGGCCCCGCAGAGAAAGGGCC	0.731000													6	8					0	0	1	0	0
SGMS1	259230	broad.mit.edu	37	10	52103313	52103313	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:52103313C>T	ENST00000361781.2	-	7	1521	c.562G>A	c.(562-564)Gaa>Aaa	p.E188K	SGMS1_ENST00000429490.1_Intron|SGMS1_ENST00000361543.2_Missense_Mutation_p.E188K	NM_147156.3	NP_671512.1	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	194					apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	16						CCATTAATTTCACAAATAGAA	0.433000													21	5					0	0	1	0	0
OR11H6	122748	broad.mit.edu	37	14	20692623	20692623	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:20692623G>A	ENST00000315519.2	+	1	833	c.755G>A	c.(754-756)cGa>cAa	p.R252Q		NM_001004480.1	NP_001004480.1	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H, member 6	252					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(13)|ovary(2)|prostate(1)|skin(2)	29	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		GGTGCTGGTCGAACTAAAGCT	0.483000													16	39					0	0	1	0	0
FBXO44	93611	broad.mit.edu	37	1	11718796	11718796	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:11718796C>T	ENST00000251546.4	+	4	604	c.367C>T	c.(367-369)Cgc>Tgc	p.R123C	FBXO44_ENST00000251547.5_Silent_p.F164F|FBXO44_ENST00000376760.1_Missense_Mutation_p.R123C|FBXO44_ENST00000376768.1_Missense_Mutation_p.R155C|FBXO44_ENST00000376770.1_Silent_p.F164F|FBXO44_ENST00000376762.4_Missense_Mutation_p.R123C	NM_183412.2	NP_904319.1	Q9H4M3	FBX44_HUMAN	F-box protein 44	123	FBA.				protein catabolic process	SCF ubiquitin ligase complex	protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	8	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.41e-06)|COAD - Colon adenocarcinoma(227;0.000255)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000758)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		CCTGCAGGTTCGCAGCCAGGC	0.706000													20	90					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47570981	47570981	+	Missense_Mutation	SNP	G	G	A	rs147568390	byFrequency	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:47570981G>A	ENST00000273859.3	+	16	3250	c.2981G>A	c.(2980-2982)cGa>cAa	p.R994Q		NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	994					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						TCAGGGTTACGAGCTGGACTC	0.483000													20	59					0	0	1	0	0
KIF15	56992	broad.mit.edu	37	3	44816861	44816861	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:44816861C>T	ENST00000326047.4	+	3	327	c.178C>T	c.(178-180)Cgg>Tgg	p.R60W		NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15	60	Kinesin-motor.				blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		CACGAGTCTCCGGCTGCACTC	0.448000													13	36					0	0	1	0	0
OXTR	5021	broad.mit.edu	37	3	8809178	8809178	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:8809178C>T	ENST00000316793.3	-	3	1320	c.696G>A	c.(694-696)cgG>cgA	p.R232R	CAV3_ENST00000472766.1_Intron	NM_000916.3	NP_000907.2	P30559	OXYR_HUMAN	oxytocin receptor	232					female pregnancy|lactation|muscle contraction	integral to plasma membrane	oxytocin receptor activity|vasopressin receptor activity			NS(1)|endometrium(2)|large_intestine(4)|lung(5)|urinary_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(96;0.15)	Carbetocin(DB01282)	CGGTCTTGAGCCGCAAGTTCT	0.662000													6	8					0	0	1	0	0
NPY4R	5540	broad.mit.edu	37	10	47087903	47087903	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:47087903C>T	ENST00000374312.1	+	3	1539	c.1120C>T	c.(1120-1122)Ccc>Tcc	p.P374S	NPY4R_ENST00000395716.1_Missense_Mutation_p.P374S	NM_005972.4	NP_005963.3			neuropeptide Y receptor Y4																		CAGGTCCAATCCCATTTAACC	0.592000													24	42					0	0	1	0	0
LAPTM5	7805	broad.mit.edu	37	1	31214502	31214502	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:31214502C>T	ENST00000294507.3	-	3	317	c.243G>A	c.(241-243)ctG>ctA	p.L81L		NM_006762.2	NP_006753.1	Q13571	LAPM5_HUMAN	lysosomal protein transmembrane 5	81					transport	integral to plasma membrane|lysosomal membrane				large_intestine(2)|lung(7)|skin(1)	10		Colorectal(325;0.0199)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0966)|Medulloblastoma(700;0.151)|Ovarian(437;0.192)		STAD - Stomach adenocarcinoma(196;0.0196)|READ - Rectum adenocarcinoma(331;0.0649)		CTACGCCGATCAGTAGGCTCA	0.612000													13	1					0	0	1	0	0
SRGAP2	23380	broad.mit.edu	37	1	206632056	206632056	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:206632056C>T	ENST00000419187.2	+	19	2212	c.549C>T	c.(547-549)tcC>tcT	p.183_183insS	SRGAP2_ENST00000414007.1_Silent_p.S725S			O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	0					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			NS(1)|breast(1)|kidney(1)|lung(1)	4	Breast(84;0.137)					CTGACTCCTCCTCCCCAGGGG	0.582000													5	22					0	0	1	0	0
RUSC2	9853	broad.mit.edu	37	9	35555193	35555193	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:35555193C>T	ENST00000455600.1	+	3	2720	c.2151C>T	c.(2149-2151)tcC>tcT	p.S717S		NM_001135999.1	NP_001129471.1	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	717						cytosol				NS(1)|breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(4)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			ACAGCCTTTCCCAGCTCTACA	0.652000													22	78					0	0	1	0	0
LOXL2	4017	broad.mit.edu	37	8	23217644	23217644	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:23217644G>A	ENST00000389131.3	-	3	859	c.490C>T	c.(490-492)Cct>Tct	p.P164S	RP11-177H13.2_ENST00000519692.1_RNA	NM_002318.2	NP_002309.1	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2	164					aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(5)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		TTGAACCCAGGAATCCTTTTG	0.498000													19	20					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10265785	10265785	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:10265785C>T	ENST00000418404.3	-	3	403	c.240G>A	c.(238-240)atG>atA	p.M80I	MYH13_ENST00000570743.1_Missense_Mutation_p.M80I|MYH13_ENST00000252172.4_Missense_Mutation_p.M80I			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	80	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						TGGGAGGGTTCATGGGGAAGA	0.483000													67	14					0	0	1	0	0
ERN2	10595	broad.mit.edu	37	16	23718370	23718370	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:23718370G>A	ENST00000256797.4	-	5	649	c.481C>T	c.(481-483)Cat>Tat	p.H161Y	ERN2_ENST00000457008.2_Missense_Mutation_p.H113Y	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	113					apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		GGAGAGGCATGAACCAGCTCA	0.552000													15	19					0	0	1	0	0
PPIAL4G	644591	broad.mit.edu	37	1	143767491	143767491	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:143767491C>T	ENST00000419275.1	-	1	390	c.358G>A	c.(358-360)Gag>Aag	p.E120K		NM_001123068.1	NP_001116540.1	A2BFH1	PAL4G_HUMAN	peptidylprolyl isomerase A (cyclophilin A)-like 4G	120	PPIase cyclophilin-type.				protein folding	cytoplasm	peptidyl-prolyl cis-trans isomerase activity			breast(1)|endometrium(2)|kidney(1)|lung(8)|ovary(1)|skin(1)	14						TCCAACCACTCAGTCTTGGCA	0.488000													89	270					0	0	1	0	0
NGB	58157	broad.mit.edu	37	14	77734832	77734832	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:77734832C>T	ENST00000298352.4	-	3	672	c.298G>A	c.(298-300)Ggt>Agt	p.G100S		NM_021257.3	NP_067080.1	Q9NPG2	NGB_HUMAN	neuroglobin	100	Globin.					hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	8			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0273)		AGCTTCACACCCACTGCCCGG	0.602000													35	20					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73829471	73829471	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:73829471C>T	ENST00000264448.6	+	20	12382	c.12271C>T	c.(12271-12273)Cgc>Tgc	p.R4091C	ALMS1_ENST00000464408.2_3'UTR|ALMS1_ENST00000409009.1_Missense_Mutation_p.R4049C	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	4091					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						CCACCAGAATCGCATGTGCCC	0.562000													37	18					0	0	1	0	0
PDLIM4	8572	broad.mit.edu	37	5	131606686	131606686	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:131606686C>T	ENST00000253754.3	+	4	470	c.406C>T	c.(406-408)Cca>Tca	p.P136S	PDLIM4_ENST00000379018.3_Missense_Mutation_p.P136S|P4HA2_ENST00000471826.1_Intron|PDLIM4_ENST00000484620.1_3'UTR	NM_001131027.1|NM_003687.3	NP_001124499.1|NP_003678.2	P50479	PDLI4_HUMAN	PDZ and LIM domain 4	136							protein binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)|urinary_tract(1)	10			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCTGGGATCTCCATATGGACA	0.632000													74	16					0	0	1	0	0
MICALL1	85377	broad.mit.edu	37	22	38318091	38318091	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:38318091G>A	ENST00000215957.6	+	6	808	c.682G>A	c.(682-684)Ggg>Agg	p.G228R		NM_033386.3	NP_203744.1	Q8N3F8	MILK1_HUMAN	MICAL-like 1	228						cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	24	Melanoma(58;0.045)					GACACGGTCGGGGACCAGGCC	0.647000													20	47					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114195792	114195792	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:114195792C>T	ENST00000357077.4	+	15	1723	c.1670C>T	c.(1669-1671)tCc>tTc	p.S557F	ANK2_ENST00000394537.3_Missense_Mutation_p.S557F|ANK2_ENST00000264366.6_Missense_Mutation_p.S557F|ANK2_ENST00000506722.1_Missense_Mutation_p.S536F	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	557					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GCAGCCCACTCCTTAGCTACC	0.522000													7	24					0	0	1	0	0
EZR	7430	broad.mit.edu	37	6	159206477	159206477	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:159206477G>A	ENST00000367075.3	-	5	499	c.331C>T	c.(331-333)Ctt>Ttt	p.L111F	EZR_ENST00000476189.1_5'UTR|EZR_ENST00000392177.4_Missense_Mutation_p.L79F|EZR_ENST00000337147.7_Missense_Mutation_p.L111F	NM_001111077.1	NP_001104547.1	P15311	EZRI_HUMAN	ezrin	111	FERM.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding		EZR/ROS1(4)	breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)	15		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		TCATCGCTAAGGATTCCTTCC	0.527000			T	ROS1	NSCLC								23	18					0	0	1	0	0
ZNF12	7559	broad.mit.edu	37	7	6732100	6732100	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:6732100C>G	ENST00000405858.1	-	5	1014	c.473G>C	c.(472-474)gGa>gCa	p.G158A	ZNF12_ENST00000342651.5_Missense_Mutation_p.G120A|AC073343.13_ENST00000366167.2_RNA|ZNF12_ENST00000404360.1_Missense_Mutation_p.G84A	NM_006956.2|NM_016265.3	NP_008887.2|NP_057349.2	P17014	ZNF12_HUMAN	zinc finger protein 12	158					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|endometrium(1)|large_intestine(1)|lung(7)|prostate(2)|upper_aerodigestive_tract(3)	16		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		TGCATAGCTTCCATCACTACT	0.373000													14	33					0	0	1	0	0
IGHV3-30	28439	broad.mit.edu	37	14	106791273	106791273	+	RNA	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:106791273C>T	ENST00000390613.2	-	0	162																											GACCACGCCTCCCCCAGACTC	0.562000													55	201					0	0	1	0	0
PDE11A	50940	broad.mit.edu	37	2	178704995	178704995	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:178704995G>A	ENST00000286063.5	-	6	1800	c.1483C>T	c.(1483-1485)Ccg>Tcg	p.P495S	PDE11A_ENST00000497003.1_5'UTR|PDE11A_ENST00000449286.2_Missense_Mutation_p.P137S|PDE11A_ENST00000389683.3_Missense_Mutation_p.P51S|PDE11A_ENST00000409504.1_Missense_Mutation_p.P137S|PDE11A_ENST00000358450.4_Missense_Mutation_p.P245S	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A	495	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TCAAAGCGCGGATCCTGGTAG	0.453000									Primary Pigmented Nodular Adrenocortical Disease, Familial				14	43					0	0	1	0	0
MAP1LC3A	84557	broad.mit.edu	37	20	33137834	33137834	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:33137834G>A	ENST00000374837.3	+	2	188		c.e2+1			NM_181509.2	NP_852610.1	Q9H492	MLP3A_HUMAN	microtubule-associated protein 1 light chain 3 alpha						autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|cytosol|endomembrane system|microtubule	phosphatidylethanolamine binding|protein binding			cervix(1)|kidney(1)|large_intestine(1)|upper_aerodigestive_tract(2)	5						GTGGACCCAGGTCTGTCTGGC	0.572000													12	41					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31391630	31391630	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:31391630C>T	ENST00000268296.4	+	27	3225	c.3104C>T	c.(3103-3105)cCc>cTc	p.P1035L	ITGAX_ENST00000562522.1_Missense_Mutation_p.P1035L	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	1035					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						TGTGACGTCCCCTCCTTCAGC	0.612000													13	18					0	0	1	0	0
OR51L1	119682	broad.mit.edu	37	11	5020782	5020782	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:5020782C>T	ENST00000321543.1	+	1	570	c.570C>T	c.(568-570)tcC>tcT	p.S190S		NM_001004755.1	NP_001004755.1	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L, member 1	190					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(19)|skin(2)|stomach(1)	31		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TAAGATTATCCTGTACAGATG	0.438000													41	27					0	0	1	0	0
FTCD	10841	broad.mit.edu	37	21	47571477	47571477	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr21:47571477C>T	ENST00000397748.1	-	5	674	c.631G>A	c.(631-633)Gac>Aac	p.D211N	FTCD_ENST00000397746.3_Missense_Mutation_p.D211N|FTCD_ENST00000498355.2_5'UTR|FTCD_ENST00000397743.1_Missense_Mutation_p.D211N|FTCD_ENST00000355384.2_Missense_Mutation_p.D211N|FTCD_ENST00000291670.5_Missense_Mutation_p.D211N|FTCD_ENST00000359679.2_Missense_Mutation_p.D211N			O95954	FTCD_HUMAN	formimidoyltransferase cyclodeaminase	211	Formiminotransferase C-subdomain (By similarity).				folic acid-containing compound metabolic process|histidine catabolic process	centriole|cytosol|Golgi apparatus	folic acid binding|formimidoyltetrahydrofolate cyclodeaminase activity|glutamate formimidoyltransferase activity			endometrium(1)|large_intestine(2)|lung(9)|pancreas(1)|prostate(3)|skin(3)	19	Breast(49;0.214)			Colorectal(79;0.235)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	GTCACCTGGTCCTTCCCGCGG	0.647000													25	46					0	0	1	0	0
HACE1	57531	broad.mit.edu	37	6	105244589	105244589	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:105244589G>A	ENST00000262903.4	-	9	1033	c.757C>T	c.(757-759)Ccg>Tcg	p.P253S	HACE1_ENST00000369125.2_Missense_Mutation_p.P253S	NM_020771.3	NP_065822.2	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	253					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	44		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		AAAAGCCTCGGGTGATATTGA	0.328000													18	8					0	0	1	0	0
USP13	8975	broad.mit.edu	37	3	179437811	179437811	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:179437811C>T	ENST00000263966.3	+	7	1360	c.889C>T	c.(889-891)Cat>Tat	p.H297Y	USP13_ENST00000496897.1_Missense_Mutation_p.H232Y|USP13_ENST00000482333.1_3'UTR	NM_003940.2	NP_003931.2	Q92995	UBP13_HUMAN	ubiquitin specific peptidase 13 (isopeptidase T-3)	297					ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding	p.H297N(1)		central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	46	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			TGATATGCTTCATATGCATGG	0.413000													366	33					0	0	1	0	0
AKNA	80709	broad.mit.edu	37	9	117113183	117113183	+	Silent	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:117113183T>C	ENST00000307564.4	-	15	3338	c.3177A>G	c.(3175-3177)ccA>ccG	p.P1059P	AKNA_ENST00000374088.3_Silent_p.P1059P|AKNA_ENST00000223791.3_Silent_p.P519P|AKNA_ENST00000374075.5_Silent_p.P978P	NM_030767.4	NP_110394.3	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	1059					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						TGGTCTCTGTTGGTCCACAGG	0.597000													48	29					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57767840	57767840	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:57767840G>A	ENST00000371030.2	+	1	1766	c.1766G>A	c.(1765-1767)aGa>aAa	p.R589K		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	589						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GACGCAAAGAGAACTGCTGCG	0.682000													9	51					0	0	1	0	0
ADAM33	80332	broad.mit.edu	37	20	3649647	3649647	+	Splice_Site	SNP	G	G	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:3649647G>T	ENST00000356518.2	-	22	2646	c.2404_splice	c.e22-1	p.A802_splice	ADAM33_ENST00000379861.4_Intron|ADAM33_ENST00000466620.1_5'UTR|ADAM33_ENST00000350009.2_Splice_Site_p.A776_splice	NM_025220.2	NP_079496.1	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33	802				Missing (in Ref. 2; AAM80482/AAM80483).	proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|skin(3)	29						GACTTGATCTGCTGAGAATGA	0.537000													21	179					2.98393e-07	3.00743e-07	1	1	0
TAS2R41	259287	broad.mit.edu	37	7	143175418	143175418	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:143175418G>A	ENST00000408916.1	+	1	453	c.453G>A	c.(451-453)gtG>gtA	p.V151V	EPHA1-AS1_ENST00000429289.1_RNA	NM_176883.2	NP_795364.2	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	151					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(2)|skin(1)	18	Melanoma(164;0.15)					TTTTTTGGGTGAACTACCCTG	0.448000													8	26					0	0	1	0	0
PHEX	5251	broad.mit.edu	37	X	22129637	22129637	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:22129637C>T	ENST00000379374.4	+	10	1697	c.1132C>T	c.(1132-1134)Ctt>Ttt	p.L378F	PHEX_ENST00000535894.1_Missense_Mutation_p.L281F|PHEX_ENST00000537599.1_Missense_Mutation_p.L378F|PHEX_ENST00000418858.3_Missense_Mutation_p.L81F	NM_000444.4	NP_000435.3	P78562	PHEX_HUMAN	phosphate regulating endopeptidase homolog, X-linked	378					biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(12)|liver(1)|lung(19)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	42						AATTCCAAACCTTAGCAGGCG	0.393000													85	12					0	0	1	0	0
GPR156	165829	broad.mit.edu	37	3	119886852	119886852	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:119886852G>A	ENST00000464295.1	-	10	1917	c.1472C>T	c.(1471-1473)cCa>cTa	p.P491L	GPR156_ENST00000315843.3_Missense_Mutation_p.P491L|GPR156_ENST00000461057.1_Missense_Mutation_p.P487L			Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	491						integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|prostate(1)|skin(1)	32				GBM - Glioblastoma multiforme(114;0.19)		CTCAGTCCATGGCTTCTGGCT	0.537000													39	107					0	0	1	0	0
OR6F1	343169	broad.mit.edu	37	1	247875554	247875554	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:247875554G>A	ENST00000302084.2	-	1	551	c.504C>T	c.(502-504)ttC>ttT	p.F168F	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005286.1	NP_001005286.1	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F, member 1	168					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F168F(1)		breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GGGGGCCACAGAAGGACAGGC	0.597000													105	36					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121008170	121008170	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:121008170C>T	ENST00000392793.1	+	11	3253	c.2982C>T	c.(2980-2982)atC>atT	p.I994I	TECTA_ENST00000264037.2_Silent_p.I994I			O75443	TECTA_HUMAN	tectorin alpha	994	TIL 2.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		AGGAGTGCATCACATGTACAG	0.537000													15	36					0	0	1	0	0
LEPR	3953	broad.mit.edu	37	1	66088592	66088592	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:66088592G>A	ENST00000349533.6	+	19	2786	c.2601G>A	c.(2599-2601)atG>atA	p.M867I	LEPR_ENST00000371058.1_Missense_Mutation_p.M867I|LEPR_ENST00000406510.3_Intron|LEPR_ENST00000371059.3_Missense_Mutation_p.M867I|LEPR_ENST00000371060.3_Missense_Mutation_p.M867I|LEPR_ENST00000344610.8_Missense_Mutation_p.M867I	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	867					energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TTTGTAGAATGAAAAAGCTAT	0.358000													8	46					0	0	1	0	0
ALDH7A1	501	broad.mit.edu	37	5	125894994	125894994	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:125894994G>A	ENST00000409134.3	-	11	1165	c.946C>T	c.(946-948)Cca>Tca	p.P316S	ALDH7A1_ENST00000447989.2_Missense_Mutation_p.P343S|ALDH7A1_ENST00000553117.1_Missense_Mutation_p.P316S	NM_001182.4|NM_001201377.1	NP_001173.2|NP_001188306.1	P49419	AL7A1_HUMAN	aldehyde dehydrogenase 7 family, member A1	316					cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound	cytosol|mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity|betaine-aldehyde dehydrogenase activity|L-aminoadipate-semialdehyde dehydrogenase activity			endometrium(1)|kidney(4)|large_intestine(4)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	16		all_cancers(142;0.24)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0417)|OV - Ovarian serous cystadenocarcinoma(64;0.068)|all cancers(49;0.109)	NADH(DB00157)|Pyridoxine(DB00165)	AGAGCTGATGGAACAACTAAG	0.488000													15	4					0	0	1	0	0
POF1B	79983	broad.mit.edu	37	X	84537324	84537324	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:84537324C>T	ENST00000262753.4	-	16	1795		c.e16-1		POF1B_ENST00000373145.3_Splice_Site	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B								actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						TGTCCTGTACCTGTTGGCAAG	0.383000													21	2					0	0	1	0	0
BOD1L2	284257	broad.mit.edu	37	18	54814883	54814883	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr18:54814883G>A	ENST00000585477.1	+	1	591	c.340G>A	c.(340-342)Gct>Act	p.A114T		NM_001257964.1	NP_001244893.1			biorientation of chromosomes in cell division 1-like 2																		GAGGTCAGAAGCTGGAGTGGA	0.488000													14	21					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178409974	178409974	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:178409974G>A	ENST00000231188.5	-	9	2551	c.2373C>T	c.(2371-2373)acC>acT	p.T791T	GRM6_ENST00000517717.1_Silent_p.T791T|RP11-281O15.4_ENST00000519491.1_RNA	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	791					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		TGATGCAGGTGGTGTACATGG	0.592000													22	9					0	0	1	0	0
PRKD1	5587	broad.mit.edu	37	14	30068238	30068238	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:30068238G>A	ENST00000331968.5	-	15	2390	c.2161C>T	c.(2161-2163)Cct>Tct	p.P721S	PRKD1_ENST00000415220.2_Missense_Mutation_p.P729S	NM_002742.2	NP_002733.2	Q15139	KPCD1_HUMAN	protein kinase D1	721	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|lung(32)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	78	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		CTTGCCTGAGGAAAAGGATCA	0.423000													4	91					0	0	1	0	0
ZNF532	55205	broad.mit.edu	37	18	56586122	56586122	+	Silent	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr18:56586122T>C	ENST00000336078.4	+	4	1379	c.603T>C	c.(601-603)gtT>gtC	p.V201V	ZNF532_ENST00000591808.1_Silent_p.V201V|ZNF532_ENST00000589288.1_Silent_p.V201V|ZNF532_ENST00000591230.1_Silent_p.V201V|ZNF532_ENST00000591083.1_Silent_p.V201V	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	201					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						ACAAAGCTGTTAAGAGAGAAA	0.443000													71	94					0	0	1	0	0
OR1L1	26737	broad.mit.edu	37	9	125423983	125423983	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:125423983G>A	ENST00000373686.1	+	1	139	c.139G>A	c.(139-141)Gaa>Aaa	p.E47K				Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L, member 1	47					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)	17						ATCTTTAGGTGAACCCACAAC	0.388000													25	21					0	0	1	0	0
SPAG5	10615	broad.mit.edu	37	17	26918885	26918885	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:26918885G>A	ENST00000321765.5	-	4	1600	c.1268C>T	c.(1267-1269)cCt>cTt	p.P423L		NM_006461.3	NP_006452.3	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	423					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	43	Lung NSC(42;0.00431)					CAGATCTGGAGGCCGGCTGCA	0.542000													28	14					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35740309	35740309	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:35740309C>T	ENST00000440995.2	+	23	3255	c.3255C>T	c.(3253-3255)tcC>tcT	p.S1085S	CTD-2113L7.1_ENST00000510433.1_RNA|SPEF2_ENST00000356031.3_Silent_p.S1090S			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1090					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ATTTCAACTCCCTTCCTGATG	0.438000													35	62					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102467310	102467310	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:102467310C>T	ENST00000360184.4	+	19	4258	c.4094C>T	c.(4093-4095)gCc>gTc	p.A1365V		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	1365	Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						AATTTGGATGCCCTCCTGAAC	0.418000													35	95					0	0	1	0	0
ELN	2006	broad.mit.edu	37	7	73483003	73483003	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:73483003G>A	ENST00000252034.7	+	33	2547	c.2148G>A	c.(2146-2148)ggG>ggA	p.G716G	ELN_ENST00000320492.7_Silent_p.G635G|ELN_ENST00000380584.4_Silent_p.G650G|ELN_ENST00000320399.6_Silent_p.G749G|ELN_ENST00000358929.4_Silent_p.G784G|ELN_ENST00000380553.4_Silent_p.G562G|ELN_ENST00000380562.4_Silent_p.G722G|ELN_ENST00000458204.1_Silent_p.G706G|ELN_ENST00000414324.1_Silent_p.G692G|ELN_ENST00000357036.5_Silent_p.G703G|ELN_ENST00000380575.4_Silent_p.G669G|ELN_ENST00000429192.1_Silent_p.G684G|ELN_ENST00000445912.1_Silent_p.G698G|ELN_ENST00000380576.5_Silent_p.G697G	NM_000501.2	NP_000492.2	P15502	ELN_HUMAN	elastin	778	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	CCTGCCTGGGGAAAGCTTGTG	0.577000			T	PAX5	B-ALL		"""Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"""						21	23					0	0	1	0	0
UCHL3	7347	broad.mit.edu	37	13	76134927	76134927	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:76134927C>T	ENST00000377595.3	+	3	123	c.93C>T	c.(91-93)ttC>ttT	p.F31F	RP11-29G8.3_ENST00000563635.1_RNA	NM_001270952.1|NM_006002.3	NP_001257881.1|NP_005993.1	P15374	UCHL3_HUMAN	ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)	31					ubiquitin-dependent protein catabolic process	cytoplasm	cysteine-type peptidase activity|ubiquitin binding|ubiquitin thiolesterase activity	p.F31F(1)		kidney(1)|large_intestine(2)|lung(3)|skin(1)	7				GBM - Glioblastoma multiforme(99;0.0125)		ACTGGCAATTCGTTGATGTAT	0.338000													20	15					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7548808	7548808	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:7548808T>A	ENST00000313599.3	-	8	1990	c.1933A>T	c.(1933-1935)Att>Ttt	p.I645F	CD163L1_ENST00000416109.2_Missense_Mutation_p.I655F|CD163L1_ENST00000396630.1_Missense_Mutation_p.I645F			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	645	SRCR 6.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						TCGAGCCAAATTTTTCCATAT	0.483000													10	14					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41365276	41365276	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:41365276C>T	ENST00000547849.1	+	16	2164	c.1845C>T	c.(1843-1845)tcC>tcT	p.S615S	CNTN1_ENST00000347616.1_Intron|CNTN1_ENST00000551295.2_Intron|CNTN1_ENST00000348761.2_Intron|CNTN1_ENST00000360099.3_Silent_p.S615S|CNTN1_ENST00000547702.1_Silent_p.S615S	NM_001256064.1	NP_001242993.1	Q12860	CNTN1_HUMAN	contactin 1	0	Fibronectin type-III 1.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TGGTGGATTCCTTTCTCCCCG	0.433000													7	16					0	0	1	0	0
NSMAF	8439	broad.mit.edu	37	8	59509987	59509987	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:59509987G>A	ENST00000038176.3	-	21	1963	c.1751C>T	c.(1750-1752)tCc>tTc	p.S584F	NSMAF_ENST00000427130.2_Missense_Mutation_p.S615F	NM_003580.3	NP_003571.2	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation associated factor	584					ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	38		all_lung(136;0.174)|Lung NSC(129;0.2)				GGAGGTCTGGGACAAACTTTT	0.403000													85	79					0	0	1	0	0
RIMS4	140730	broad.mit.edu	37	20	43386718	43386718	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:43386718G>A	ENST00000372851.3	-	3	410	c.344C>T	c.(343-345)cCc>cTc	p.P115L	RIMS4_ENST00000541604.2_Missense_Mutation_p.P116L	NM_001205317.1|NM_182970.3	NP_001192246.1|NP_892015.1	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	115	C2.				exocytosis|neurotransmitter transport	cell junction|synapse				central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(5)|urinary_tract(1)	29		Myeloproliferative disorder(115;0.0122)				CTCACCCATGGGTGTGGTGGC	0.602000													27	58					0	0	1	0	0
ATXN2	6311	broad.mit.edu	37	12	111990157	111990157	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:111990157C>T	ENST00000377617.3	-	5	1139	c.978G>A	c.(976-978)gaG>gaA	p.E326E	ATXN2_ENST00000549455.1_Intron|ATXN2_ENST00000550104.1_Silent_p.E326E|ATXN2_ENST00000542287.2_Silent_p.E61E|ATXN2_ENST00000535949.1_Silent_p.E37E|ATXN2_ENST00000389153.4_Silent_p.E61E	NM_002973.3	NP_002964.3	Q99700	ATX2_HUMAN	ataxin 2	326					cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	37						ACAAAATACTCTCCATTATTT	0.373000													4	28					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15756624	15756624	+	Silent	SNP	C	C	T	rs116936513	by1000genomes	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:15756624C>T	ENST00000221307.7	+	3	342	c.294C>T	c.(292-294)atC>atT	p.I98I	CYP4F3_ENST00000586182.1_Intron|CYP4F3_ENST00000591058.1_Intron|CYP4F3_ENST00000585846.1_Intron	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	98					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding	p.I98I(1)		endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						GGCACGCAATCGTCCGCATCT	0.582000													24	17					0	0	1	0	0
ADCK1	57143	broad.mit.edu	37	14	78392252	78392252	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:78392252C>T	ENST00000238561.5	+	9	1253	c.1154C>T	c.(1153-1155)tCg>tTg	p.S385L	ADCK1_ENST00000556560.1_3'UTR|ADCK1_ENST00000341211.5_Missense_Mutation_p.S317L	NM_020421.3	NP_065154.2	Q86TW2	ADCK1_HUMAN	aarF domain containing kinase 1	392	Protein kinase.					extracellular region	ATP binding|protein serine/threonine kinase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|skin(2)|stomach(2)	25			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)		ACGGCGCGATCGTGGGACTCG	0.602000													54	185					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117768733	117768733	+	Missense_Mutation	SNP	G	G	A	rs80348085		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:117768733G>A	ENST00000317775.6	-	2	827	c.142C>T	c.(142-144)Cgt>Tgt	p.R48C	NOS1_ENST00000344089.3_Missense_Mutation_p.R48C|NOS1_ENST00000338101.4_Missense_Mutation_p.R48C	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	48	Interaction with NOSIP (By similarity).|PDZ.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding	p.R48C(2)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	GCGCCCCCACGAATCAGGTCA	0.597000													20	42					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70954605	70954605	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:70954605C>T	ENST00000393567.2	-	46	7824	c.7674G>A	c.(7672-7674)ggG>ggA	p.G2558G		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	2558			G -> E (in dbSNP:rs8044142).							breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				tctccttcttcccttcgtggt	0.632000													6	8					0	0	1	0	0
KLHDC8A	55220	broad.mit.edu	37	1	205312494	205312494	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:205312494C>T	ENST00000367156.3	-	5	1055	c.239G>A	c.(238-240)cGg>cAg	p.R80Q	KLHDC8A_ENST00000460687.1_Intron|KLHDC8A_ENST00000537168.1_Intron|KLHDC8A_ENST00000367155.3_Missense_Mutation_p.R80Q|KLHDC8A_ENST00000539253.1_Missense_Mutation_p.R80Q	NM_001271863.1	NP_001258792.1	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	80										breast(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			CACCATGATCCGCTTCCCCAG	0.657000													34	220					0	0	1	0	0
ZNF525	170958	broad.mit.edu	37	19	53884473	53884473	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:53884473C>T	ENST00000467003.1	+	4	734	c.533C>T	c.(532-534)tCt>tTt	p.S178F	ZNF525_ENST00000474037.1_Missense_Mutation_p.S214F|ZNF525_ENST00000593918.1_Intron|ZNF525_ENST00000475179.1_Intron					zinc finger protein 525											endometrium(3)|kidney(3)|lung(3)	9						AGAGAAAAATCTTTCCAATGT	0.333000													29	19					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136566232	136566232	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:136566232C>T	ENST00000264162.2	-	8	3695	c.3685G>A	c.(3685-3687)Gac>Aac	p.D1229N		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1229	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		ATCTCCTGGTCGTCTTCGTAG	0.592000													23	124					0	0	1	0	0
PI4KB	5298	broad.mit.edu	37	1	151282724	151282724	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:151282724G>A	ENST00000368875.2	-	4	1533	c.953C>T	c.(952-954)tCc>tTc	p.S318F	PI4KB_ENST00000368873.1_Missense_Mutation_p.S306F|PI4KB_ENST00000271657.5_Missense_Mutation_p.S318F|PI4KB_ENST00000529142.1_Intron|PI4KB_ENST00000368874.4_Intron|PI4KB_ENST00000368872.1_Intron	NM_002651.2	NP_002642.1	Q9UBF8	PI4KB_HUMAN	phosphatidylinositol 4-kinase, catalytic, beta	306					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(5)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GGTGCTGGAGGAGAGCTCCTg	0.577000													3	16					0	0	1	0	0
ERN2	10595	broad.mit.edu	37	16	23712304	23712304	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:23712304C>T	ENST00000256797.4	-	12	1647	c.1479G>A	c.(1477-1479)ggG>ggA	p.G493G	ERN2_ENST00000457008.2_Intron	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	445					apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		AGAGAATCCACCCTCCCAGGA	0.572000													25	45					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77692498	77692498	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:77692498G>A	ENST00000360084.5	-	57	8275	c.572C>T	c.(571-573)tCc>tTc	p.S191F	MYCBP2_ENST00000407578.2_Intron|MYCBP2_ENST00000544440.2_Intron|MYCBP2_ENST00000482517.1_5'UTR|MYCBP2_ENST00000357337.6_Intron			O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	2674					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CTGCTGGAAGGAAAGGGGCTG	0.483000													5	10					0	0	1	0	0
AKNA	80709	broad.mit.edu	37	9	117138749	117138749	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:117138749G>A	ENST00000307564.4	-	3	1499	c.1338C>T	c.(1336-1338)ctC>ctT	p.L446L	AKNA_ENST00000374088.3_Silent_p.L446L|AKNA_ENST00000312033.3_Silent_p.L446L|AKNA_ENST00000223791.3_5'UTR|AKNA_ENST00000374075.5_Silent_p.L365L	NM_030767.4	NP_110394.3	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	446					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.L446L(1)		breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						CACTAACCTGGAGCTGATGGA	0.602000													8	36					0	0	1	0	0
OR2G2	81470	broad.mit.edu	37	1	247751917	247751917	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:247751917G>A	ENST00000320065.1	+	1	256	c.256G>A	c.(256-258)Gta>Ata	p.V86I	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	86					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CCAGCTCCTGGTAAACCTGTG	0.522000													22	153					0	0	1	0	0
DPYS	1807	broad.mit.edu	37	8	105405118	105405118	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:105405118A>T	ENST00000351513.2	-	8	1469	c.1337T>A	c.(1336-1338)gTg>gAg	p.V446E	DPYS_ENST00000521601.1_Intron	NM_001385.2	NP_001376.1	Q14117	DPYS_HUMAN	dihydropyrimidinase	446					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TTCATATACCACTTTGCCTCT	0.438000													78	82					0	0	1	0	0
ZFP82	284406	broad.mit.edu	37	19	36884680	36884680	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:36884680G>A	ENST00000392161.3	-	5	804	c.562C>T	c.(562-564)Cat>Tat	p.H188Y	ZFP82_ENST00000392171.1_Missense_Mutation_p.H188Y	NM_133466.2	NP_597723.1	Q8N141	ZFP82_HUMAN	ZFP82 zinc finger protein	188					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						ATTCTGTGATGAAAAGTAAGC	0.428000													13	35					0	0	1	0	0
REST	5978	broad.mit.edu	37	4	57796967	57796967	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:57796967C>T	ENST00000309042.7	+	4	2257	c.1943C>T	c.(1942-1944)cCt>cTt	p.P648L		NM_001193508.1|NM_005612.4	NP_001180437.1|NP_005603.3	Q13127	REST_HUMAN	RE1-silencing transcription factor	648	Pro-rich.				cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	50	Glioma(25;0.08)|all_neural(26;0.181)					CGGCCTGCTCCTGACGAGCCT	0.632000													7	22					0	0	1	0	0
SLC2A6	11182	broad.mit.edu	37	9	136341422	136341422	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:136341422C>T	ENST00000371899.4	-	4	576	c.499G>A	c.(499-501)Ggg>Agg	p.G167R	SLC2A6_ENST00000371897.4_Missense_Mutation_p.G167R|SLC2A6_ENST00000485978.1_5'UTR	NM_017585.3	NP_060055.2	Q9UGQ3	GTR6_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 6	167						integral to membrane|plasma membrane	D-glucose transmembrane transporter activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(3)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(145;8.47e-08)|Epithelial(140;9.37e-07)|all cancers(34;1.03e-05)		CCCAGAGCCCCACGAACGCCT	0.622000													14	27					0	0	1	0	0
NOX1	27035	broad.mit.edu	37	X	100118164	100118164	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:100118164C>T	ENST00000372966.3	-	4	526	c.321G>A	c.(319-321)atG>atA	p.M107I	NOX1_ENST00000372960.4_Missense_Mutation_p.M70I|NOX1_ENST00000372964.1_Missense_Mutation_p.M107I|NOX1_ENST00000217885.5_Missense_Mutation_p.M107I	NM_007052.4|NM_013955.2	NP_008983.2|NP_039249.1	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1	107	Ferric oxidoreductase.				angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			cervix(1)|lung(3)|ovary(1)|skin(2)	7						GTAGGCAGATCATATAGGCCA	0.438000													72	10					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77676127	77676127	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:77676127C>T	ENST00000296043.6	+	7	5444	c.4491C>T	c.(4489-4491)tcC>tcT	p.S1497S		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	1497					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			TGCGGGACTCCCCGCCACCTC	0.587000													25	27					0	0	1	0	0
BMP2	650	broad.mit.edu	37	20	6750866	6750866	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:6750866G>A	ENST00000378827.4	+	2	1312	c.93G>A	c.(91-93)agG>agA	p.R31R		NM_001200.2	NP_001191.1	P12643	BMP2_HUMAN	bone morphogenetic protein 2	31					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	13					Simvastatin(DB00641)	TGGGCCGCAGGAAGTTCGCGG	0.692000													5	11					0	0	1	0	0
MCF2L2	23101	broad.mit.edu	37	3	183006964	183006964	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:183006964C>T	ENST00000328913.3	-	14	2017	c.1720G>A	c.(1720-1722)Gag>Aag	p.E574K	MCF2L2_ENST00000447025.2_Missense_Mutation_p.E574K|MCF2L2_ENST00000414362.2_Missense_Mutation_p.E574K|B3GNT5_ENST00000462559.1_Intron|MCF2L2_ENST00000473233.1_Missense_Mutation_p.E574K	NM_015078.2	NP_055893.2	Q86YR7	MF2L2_HUMAN	MCF.2 cell line derived transforming sequence-like 2	574					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			AACTCTGTCTCCGTATAAGGT	0.398000													9	10					0	0	1	0	0
CD1A	909	broad.mit.edu	37	1	158224896	158224896	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:158224896C>T	ENST00000289429.5	+	2	614	c.81C>T	c.(79-81)ttC>ttT	p.F27F		NM_001763.2	NP_001754.2	P06126	CD1A_HUMAN	CD1a molecule	27					antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	32	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	CTCTCTCCTTCCATGTCACCT	0.488000													20	99					0	0	1	0	0
TRAV9-2	28677	broad.mit.edu	37	14	22409792	22409792	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:22409792G>A	ENST00000390441.2	+	0	338																											CTTTCCACTTGGAGAAAGGCT	0.502000													28	26					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67709361	67709361	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr15:67709361G>A	ENST00000335894.4	+	15	2256	c.2190G>A	c.(2188-2190)agG>agA	p.R730R	IQCH_ENST00000358767.3_Silent_p.R466R|IQCH-AS1_ENST00000559298.1_lincRNA|IQCH_ENST00000360277.4_Silent_p.R391R|IQCH_ENST00000546225.1_Silent_p.R387R	NM_001031715.2	NP_001026885.1	Q86VS3	IQCH_HUMAN	IQ motif containing H	730										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		CGACGTGGAGGAAATTCCTCC	0.463000													24	2					0	0	1	0	0
ACTL8	81569	broad.mit.edu	37	1	18149678	18149678	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:18149678C>T	ENST00000375406.1	+	2	391	c.175C>T	c.(175-177)Cat>Tat	p.H59Y		NM_030812.2	NP_110439.2	Q9H568	ACTL8_HUMAN	actin-like 8	59						cytoplasm|cytoskeleton				NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	28		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		CGACATTTGCCATCCTGACAC	0.577000													21	136					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179419360	179419360	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:179419360C>T	ENST00000589042.1	-	332	88938	c.88714G>A	c.(88714-88716)Gaa>Aaa	p.E29572K	TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E20507K|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E20699K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E20632K|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E27931K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E27004K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	27931	Ig-like 135.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCACGCTTTTCCACAATGTAG	0.433000													12	67					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117342748	117342748	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:117342748G>A	ENST00000321322.6	-	15	2970	c.2969C>T	c.(2968-2970)tCc>tTc	p.S990F	DSCAML1_ENST00000527706.1_Missense_Mutation_p.S720F	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	930	Fibronectin type-III 2.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		GAAGTCCCAGGAATCTGGAGA	0.527000													23	20					0	0	1	0	0
PLEKHH1	57475	broad.mit.edu	37	14	68028984	68028984	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:68028984G>A	ENST00000329153.5	+	7	768	c.636G>A	c.(634-636)aaG>aaA	p.K212K		NM_020715.2	NP_065766.1	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	212						cytoskeleton	binding			endometrium(2)|kidney(4)|lung(12)|urinary_tract(1)	19				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		AGGGTCTGAAGGCAGCTGTGC	0.607000													14	12					0	0	1	0	0
TMC1	117531	broad.mit.edu	37	9	75369767	75369767	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:75369767G>A	ENST00000297784.5	+	12	1248	c.708G>A	c.(706-708)tcG>tcA	p.S236S	TMC1_ENST00000340019.3_Silent_p.S236S|TMC1_ENST00000396237.3_Silent_p.S236S	NM_138691.2	NP_619636.2	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	236					sensory perception of sound	integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(21)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	36						AAGAGGCATCGGCAGCAAACT	0.413000													13	15					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31323747	31323747	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr18:31323747C>T	ENST00000269197.5	+	12	3935	c.3935C>T	c.(3934-3936)tCc>tTc	p.S1312F		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1312	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						ACAGAGGGCTCCAGCATATCA	0.443000													48	81					0	0	1	0	0
BAIAP3	8938	broad.mit.edu	37	16	1392220	1392220	+	Missense_Mutation	SNP	G	G	A	rs151024049	byFrequency	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:1392220G>A	ENST00000324385.5	+	11	1156	c.998G>A	c.(997-999)gGg>gAg	p.G333E	BAIAP3_ENST00000568887.1_Missense_Mutation_p.G270E|BAIAP3_ENST00000562208.1_Missense_Mutation_p.G275E|BAIAP3_ENST00000426824.3_Missense_Mutation_p.G298E|BAIAP3_ENST00000421665.2_Missense_Mutation_p.G298E|BAIAP3_ENST00000397488.2_Missense_Mutation_p.G315E|BAIAP3_ENST00000397489.1_Missense_Mutation_p.G315E	NM_003933.4	NP_003924.2	O94812	BAIP3_HUMAN	BAI1-associated protein 3	333					G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(25)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42		Hepatocellular(780;0.0893)				CGCGCAAACGGGACAGCAGGA	0.632000													21	41					0	0	1	0	0
SAMD7	344658	broad.mit.edu	37	3	169656266	169656266	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:169656266G>A	ENST00000428432.2	+	9	1702	c.1313G>A	c.(1312-1314)gGa>gAa	p.G438E	SAMD7_ENST00000335556.3_Missense_Mutation_p.G438E	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	438										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			ATTCCTAAAGGAATTGAGCGA	0.408000													7	4					0	0	1	0	0
GJA10	84694	broad.mit.edu	37	6	90604719	90604719	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:90604719C>T	ENST00000369352.1	+	1	532	c.532C>T	c.(532-534)Ctc>Ttc	p.L178F		NM_032602.1	NP_115991.1	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10, 62kDa	178					synaptic transmission	connexon complex|integral to membrane	gap junction channel activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(17)|ovary(1)|skin(3)|urinary_tract(1)	37		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		CCAATATATTCTCTATGGGTT	0.448000													46	41					0	0	1	0	0
IGHM	3507	broad.mit.edu	37	14	106321027	106321027	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:106321027G>A	ENST00000390559.2	-	0	961																											CCTACCCTTGGGCCGGGAGAT	0.642000													8	26					0	0	1	0	0
TTLL8	164714	broad.mit.edu	37	22	50483775	50483775	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:50483775C>T	ENST00000266182.6	-	6	551	c.552G>A	c.(550-552)gtG>gtA	p.V184V	TTLL8_ENST00000440475.1_Silent_p.V184V					tubulin tyrosine ligase-like family, member 8											NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|ovary(4)	12		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		GGTGGCTGACCACCCACTTGA	0.642000													6	32					0	0	1	0	0
OR2L8	391190	broad.mit.edu	37	1	248112288	248112288	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:248112288C>T	ENST00000357191.3	+	1	129	c.129C>T	c.(127-129)tcC>tcT	p.S43S	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	43					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			GAAACCTGTCCATGATTCTTC	0.408000													52	322					0	0	1	0	0
RB1	5925	broad.mit.edu	37	13	48953743	48953743	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:48953743G>A	ENST00000267163.4	+	14	1484	c.1346G>A	c.(1345-1347)gGa>gAa	p.G449E		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	449	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(8)|p.G449fs*8(1)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TACAAACTTGGAGTTCGCTTG	0.343000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			7	14					0	0	1	0	0
ZNF382	84911	broad.mit.edu	37	19	37118320	37118320	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:37118320C>T	ENST00000435416.1	+	3	3013	c.1518C>T	c.(1516-1518)ctC>ctT	p.L506L	ZNF382_ENST00000439428.1_Silent_p.L506L|ZNF382_ENST00000423582.1_Silent_p.L458L|ZNF382_ENST00000292928.2_Silent_p.L507L			Q96SR6	ZN382_HUMAN	zinc finger protein 382	507	Required for transcriptional repression activity; probably mediates sequence- specific DNA-binding (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	34	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AATCAAACCTCATTCGCCATC	0.428000													8	33					0	0	1	0	0
ARHGEF18	23370	broad.mit.edu	37	19	7506650	7506650	+	Splice_Site	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:7506650A>G	ENST00000359920.6	+	2	907	c.655_splice	c.e2+1	p.E218_splice	ARHGEF18_ENST00000319670.9_Splice_Site_p.E60_splice|CTD-2207O23.3_ENST00000593531.1_Splice_Site_p.K176_splice	NM_001130955.1	NP_001124427.1	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 18	218					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(2)|prostate(2)|stomach(1)|urinary_tract(1)	23		Renal(5;0.0902)				TTTTTGTAGAAGGTATGGTCA	0.512000													25	87					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1481118	1481118	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:1481118C>T	ENST00000345913.4	+	8	1171	c.1080C>T	c.(1078-1080)ggC>ggT	p.G360G	TPO_ENST00000382198.1_Intron|TPO_ENST00000349624.3_Intron|TPO_ENST00000329066.4_Silent_p.G360G|TPO_ENST00000337415.3_Silent_p.G360G|TPO_ENST00000497517.2_Intron|TPO_ENST00000346956.3_Silent_p.G360G|TPO_ENST00000382201.3_Silent_p.G360G	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	360					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GGGACTCCGGCCGCGCCTACC	0.756000													4	4					0	0	1	0	0
TEX35	84066	broad.mit.edu	37	1	178490396	178490396	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:178490396C>T	ENST00000319416.2	+	8	695	c.583C>T	c.(583-585)Cgg>Tgg	p.R195W	TEX35_ENST00000258298.2_Missense_Mutation_p.R119W|TEX35_ENST00000367642.3_3'UTR|TEX35_ENST00000367639.1_Missense_Mutation_p.R203W|TEX35_ENST00000367641.3_3'UTR|TEX35_ENST00000367643.3_Missense_Mutation_p.R195W	NM_032126.4	NP_115502.2			testis expressed 35									p.R195W(1)									CAACTACAATCGGGGTAGGTA	0.498000													29	184					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51092902	51092902	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:51092902G>A	ENST00000395542.2	-	14	4102	c.3918C>T	c.(3916-3918)tcC>tcT	p.S1306S	COBL_ENST00000265136.7_Silent_p.S1224S			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	1224										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					TGCTGAACCTGGAGGCCGTCC	0.627000													26	28					0	0	1	0	0
TMEM178A	130733	broad.mit.edu	37	2	39944345	39944345	+	Missense_Mutation	SNP	G	G	A	rs146286536		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:39944345G>A	ENST00000281961.2	+	4	904	c.848G>A	c.(847-849)cGg>cAg	p.R283Q	TMEM178A_ENST00000482239.1_3'UTR	NM_152390.2	NP_689603.2			transmembrane protein 178A									p.R283Q(1)									TTTATTAGCCGGACCAAGATT	0.547000													57	31					0	0	1	0	0
RPL9	6133	broad.mit.edu	37	4	39458102	39458102	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:39458102G>A	ENST00000449470.2	-	4	763	c.315C>T	c.(313-315)atC>atT	p.I105I	RPL9_ENST00000295955.9_Silent_p.I105I	NM_001024921.2	NP_001020092.1	P32969	RL9_HUMAN	ribosomal protein L9	105					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|nucleolus|ribosome	rRNA binding|structural constituent of ribosome			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(1)|skin(1)	8						CATTCTCCTGGATAACAACGT	0.423000													17	11					0	0	1	0	0
GATA2	2624	broad.mit.edu	37	3	128200015	128200015	+	Silent	SNP	T	T	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:128200015T>G	ENST00000341105.2	-	6	1621	c.1290A>C	c.(1288-1290)gcA>gcC	p.A430A	GATA2_ENST00000430265.2_Silent_p.A416A|GATA2_ENST00000489987.1_5'UTR|GATA2_ENST00000487848.1_Silent_p.A430A	NM_032638.4	NP_116027.2	P23769	GATA2_HUMAN	GATA binding protein 2	430					blood coagulation|negative regulation of fat cell differentiation|negative regulation of fat cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of Notch signaling pathway|phagocytosis|positive regulation of angiogenesis|positive regulation of phagocytosis|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	C2H2 zinc finger domain binding|chromatin binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(58)|kidney(2)|large_intestine(3)|lung(9)|prostate(3)|skin(1)|urinary_tract(1)	79				GBM - Glioblastoma multiforme(114;0.173)		CCAGGGCAGCTGCACTGAAGG	0.612000			Mis		AML(CML blast transformation)								27	20					0	0	1	0	0
ITPR3	3710	broad.mit.edu	37	6	33653534	33653534	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:33653534C>T	ENST00000374316.5	+	42	6657	c.5597C>T	c.(5596-5598)tCc>tTc	p.S1866F	ITPR3_ENST00000605930.1_Missense_Mutation_p.S1866F			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	1866					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						ATGGGCACATCCGTGCTCATC	0.637000													19	58					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152276059	152276059	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:152276059C>T	ENST00000368799.1	-	3	11338	c.11303G>A	c.(11302-11304)gGa>gAa	p.G3768E	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3768	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCCTGTCTTCCTCCTCTCCT	0.602000									Ichthyosis				109	596					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141592000	141592000	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:141592000G>C	ENST00000442267.2	-	7	1214	c.1140C>G	c.(1138-1140)ttC>ttG	p.F380L		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	380						intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				TGGCAAATAGGAAGGTCATCC	0.448000													18	64					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039421	11039421	+	RNA	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr21:11039421C>T	ENST00000470054.1	-	0	782									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTTTCCAATTCGGTATTCACT	0.279000													14	106					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42045469	42045469	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:42045469G>A	ENST00000372584.1	-	3	6014	c.5000C>T	c.(4999-5001)gCt>gTt	p.A1667V	HIVEP3_ENST00000372583.1_Missense_Mutation_p.A1667V|HIVEP3_ENST00000460604.1_5'UTR|HIVEP3_ENST00000247584.5_Missense_Mutation_p.A1667V|HIVEP3_ENST00000429157.2_Missense_Mutation_p.A1667V	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1667					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AGGATGCGGAGCTGTGGCCAT	0.527000													63	28					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3235774	3235774	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:3235774G>A	ENST00000217939.6	-	6	6102	c.5948C>T	c.(5947-5949)tCc>tTc	p.S1983F		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1983	Ig-like C2-type 4.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GAAGATCCAGGAAATTTGGGG	0.592000													28	2					0	0	1	0	0
KIAA0195	9772	broad.mit.edu	37	17	73493244	73493244	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:73493244C>T	ENST00000314256.7	+	26	3766	c.3372C>T	c.(3370-3372)atC>atT	p.I1124I	KIAA0195_ENST00000579208.1_Silent_p.I775I|KIAA0195_ENST00000375248.5_Silent_p.I1134I	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	1124					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCACCGACATCCTGTGGCTGT	0.532000													18	66					0	0	1	0	0
SLCO1A2	6579	broad.mit.edu	37	12	21457496	21457496	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:21457496C>T	ENST00000307378.6	-	7	1174	c.454G>A	c.(454-456)Gaa>Aaa	p.E152K	SLCO1A2_ENST00000390670.3_Missense_Mutation_p.E150K|SLCO1A2_ENST00000452078.1_Missense_Mutation_p.E152K|SLCO1A2_ENST00000537524.1_Missense_Mutation_p.E20K|SLCO1A2_ENST00000458504.1_Missense_Mutation_p.E20K	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	152					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity	p.E152Q(1)|p.E152K(1)		breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						GATTTAACTTCCTTTGTACAC	0.358000													25	23					0	0	1	0	0
MROH8	140699	broad.mit.edu	37	20	35776282	35776282	+	Silent	SNP	G	G	A	rs6073495		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:35776282G>A	ENST00000400441.3	-	10	1104	c.1105C>T	c.(1105-1107)Cta>Tta	p.L369L	MROH8_ENST00000441008.2_Silent_p.L355L|MROH8_ENST00000217333.8_Silent_p.L249L					maestro heat-like repeat family member 8																		AGAGCCACTAGGTGTCCAAGT	0.493000													19	9					0	0	1	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42107506	42107506	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr15:42107506C>T	ENST00000457542.2	+	11	1506	c.1220C>T	c.(1219-1221)tCc>tTc	p.S407F	MAPKBP1_ENST00000456763.2_Missense_Mutation_p.S413F|MAPKBP1_ENST00000514566.1_Missense_Mutation_p.S407F|MAPKBP1_ENST00000260357.7_Intron|MAPKBP1_ENST00000221214.6_Missense_Mutation_p.S290F	NM_014994.2	NP_055809.2	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein 1	413										breast(6)|central_nervous_system(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		CCCCCCAGTTCCTTTATTACC	0.582000													37	7					0	0	1	0	0
STARD4	134429	broad.mit.edu	37	5	110842044	110842044	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:110842044C>T	ENST00000296632.3	-	3	273	c.139G>A	c.(139-141)Gaa>Aaa	p.E47K	STARD4_ENST00000512160.1_Missense_Mutation_p.E47K|STARD4_ENST00000509887.1_Missense_Mutation_p.E47K|STARD4_ENST00000511569.1_5'UTR|STARD4_ENST00000502322.1_Missense_Mutation_p.E47K	NM_139164.1	NP_631903.1	Q96DR4	STAR4_HUMAN	StAR-related lipid transfer (START) domain containing 4	47	START.				lipid transport		lipid binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)	12		all_cancers(142;0.00259)|all_epithelial(76;8.32e-05)|Prostate(80;0.0115)|Colorectal(10;0.0959)|Ovarian(225;0.156)|all_lung(232;0.18)|Lung NSC(167;0.248)		OV - Ovarian serous cystadenocarcinoma(64;4.91e-09)|Epithelial(69;1.39e-08)|all cancers(49;2.34e-06)|COAD - Colon adenocarcinoma(37;0.049)|Colorectal(14;0.138)		CCATTAAATTCTTCTGAGGGT	0.299000													11	4					0	0	1	0	0
HSPA2	3306	broad.mit.edu	37	14	65008503	65008503	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:65008503C>T	ENST00000247207.6	+	1	1318	c.936C>T	c.(934-936)ctC>ctT	p.L312L	HSPA2_ENST00000394709.1_Silent_p.L312L	NM_021979.3	NP_068814.2	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	312					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			breast(1)|endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		ATGCCGACCTCTTTCGCGGGA	0.652000													13	46					0	0	1	0	0
GLYAT	10249	broad.mit.edu	37	11	58480301	58480301	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:58480301G>A	ENST00000344743.3	-	4	389	c.248C>T	c.(247-249)cCc>cTc	p.P83L	GLYAT_ENST00000278400.3_Missense_Mutation_p.P83L|GLYAT_ENST00000529732.1_Missense_Mutation_p.P83L	NM_201648.2	NP_964011.2	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase	83					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity			NS(1)|autonomic_ganglia(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|urinary_tract(1)	16		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	ACAGTTTTGGGGATCTTTGGA	0.373000													29	30					0	0	1	0	0
CAPN12	147968	broad.mit.edu	37	19	39232454	39232454	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:39232454C>T	ENST00000328867.4	-	4	831	c.523G>A	c.(523-525)Gag>Aag	p.E175K	CAPN12_ENST00000601953.1_Missense_Mutation_p.E26K	NM_144691.3	NP_653292.2	Q6ZSI9	CAN12_HUMAN	calpain 12	175	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(60;2.87e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			GCCCAGAACTCATTCCGCTGT	0.627000													7	17					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7584638	7584638	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:7584638G>A	ENST00000379802.3	+	24	7484	c.7143G>A	c.(7141-7143)aaG>aaA	p.K2381K	DSP_ENST00000418664.2_Silent_p.K1782K	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2381	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TTGACCCAAAGGAGAGCCATC	0.448000													44	15					0	0	1	0	0
MCF2L2	23101	broad.mit.edu	37	3	183017897	183017897	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:183017897G>A	ENST00000328913.3	-	11	1498	c.1201C>T	c.(1201-1203)Cgg>Tgg	p.R401W	MCF2L2_ENST00000447025.2_Missense_Mutation_p.R401W|MCF2L2_ENST00000414362.2_Missense_Mutation_p.R401W|MCF2L2_ENST00000473233.1_Missense_Mutation_p.R401W	NM_015078.2	NP_055893.2	Q86YR7	MF2L2_HUMAN	MCF.2 cell line derived transforming sequence-like 2	401					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			TCCACACACCGGGGCCTGATG	0.512000													14	35					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	31227665	31227665	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:31227665G>A	ENST00000357033.4	-	65	9719	c.9513C>T	c.(9511-9513)gtC>gtT	p.V3171V	DMD_ENST00000361471.4_Silent_p.V103V|DMD_ENST00000474231.1_Silent_p.V711V|DMD_ENST00000343523.2_Silent_p.V711V|DMD_ENST00000541735.1_Silent_p.V711V|DMD_ENST00000378707.3_Silent_p.V711V|DMD_ENST00000378677.2_Silent_p.V3167V|DMD_ENST00000359836.1_Silent_p.V711V|DMD_ENST00000378702.4_Silent_p.V103V|DMD_ENST00000378723.3_Silent_p.V103V|DMD_ENST00000378680.2_Silent_p.V103V	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	3171	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CGCAGAGAGGGACGTTGACCA	0.453000													36	7					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108479241	108479241	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:108479241G>A	ENST00000408999.3	+	16	2386	c.2309G>A	c.(2308-2310)cGa>cAa	p.R770Q	RGPD4_ENST00000354986.4_Missense_Mutation_p.R770Q	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	770					intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						GGTTCTTTGCGAAATGCGGAT	0.383000													23	18					0	0	1	0	0
ZNF554	115196	broad.mit.edu	37	19	2834330	2834330	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:2834330C>T	ENST00000317243.5	+	5	1295	c.1097C>T	c.(1096-1098)aCc>aTc	p.T366I		NM_001102651.1	NP_001096121.1	Q86TJ5	ZN554_HUMAN	zinc finger protein 554	366					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|liver(3)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACAGCTCCACCCTCACGCGC	0.552000													11	39					0	0	1	0	0
SNORD113-5	767565	broad.mit.edu	37	14	101404556	101404556	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:101404556G>A	ENST00000607261.1	+	0	33					NR_003233.1																						GGAGGTGTCTGAATCAACACT	0.378000													28	74					0	0	1	0	0
ZBTB37	84614	broad.mit.edu	37	1	173842613	173842613	+	Missense_Mutation	SNP	C	C	T	rs143889150		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:173842613C>T	ENST00000427304.1	+	4	1208	c.932C>T	c.(931-933)cCc>cTc	p.P311L	ZBTB37_ENST00000367704.1_Intron|ZBTB37_ENST00000367702.1_Missense_Mutation_p.P311L|ZBTB37_ENST00000432989.1_Missense_Mutation_p.P311L|ZBTB37_ENST00000367701.4_Missense_Mutation_p.P311L	NM_001122770.1	NP_001116242.1	Q5TC79	ZBT37_HUMAN	zinc finger and BTB domain containing 37	311					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(4)	13						AGATTTAGCCCCTCCGGCAGT	0.488000													4	59					0	0	1	0	0
CPA3	1359	broad.mit.edu	37	3	148597581	148597581	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:148597581G>A	ENST00000296046.3	+	6	533	c.481G>A	c.(481-483)Gaa>Aaa	p.E161K	RP11-680B3.2_ENST00000488190.1_RNA	NM_001870.2	NP_001861.2	P15088	CBPA3_HUMAN	carboxypeptidase A3 (mast cell)	161					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			ATAGATTGGGGAAAAGAATGA	0.373000													6	38					0	0	1	0	0
DEFB110	245913	broad.mit.edu	37	6	49976967	49976967	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:49976967G>A	ENST00000393660.2	-	2	72	c.73C>T	c.(73-75)Cca>Tca	p.P25S		NM_001037728.2	NP_001032817.1	Q30KQ9	DB110_HUMAN	defensin, beta 110 locus	24					defense response to bacterium	extracellular region				endometrium(1)|lung(1)|ovary(1)	3	Lung NSC(77;0.042)					CTATACTTTGGTTCAAAATTG	0.313000													35	16					0	0	1	0	0
DUSP11	8446	broad.mit.edu	37	2	74002123	74002123	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:74002123G>A	ENST00000443070.1	-	3	372	c.367C>T	c.(367-369)Ctt>Ttt	p.L123F	DUSP11_ENST00000272444.3_Missense_Mutation_p.L123F|DUSP11_ENST00000480948.1_5'UTR|DUSP11_ENST00000377706.4_Missense_Mutation_p.L76F			O75319	DUS11_HUMAN	dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)	76					RNA processing	nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(4)|skin(1)	12						TTGTTAAAAAGATCCAAAGGG	0.343000													9	35					0	0	1	0	0
HCFC1	3054	broad.mit.edu	37	X	153216280	153216280	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:153216280G>A	ENST00000310441.7	-	23	6653	c.5687C>T	c.(5686-5688)gCc>gTc	p.A1896V	HCFC1_ENST00000354233.3_Missense_Mutation_p.A1827V|HCFC1_ENST00000369984.4_Missense_Mutation_p.A1941V	NM_005334.2	NP_005325.2	P51610	HCFC1_HUMAN	host cell factor C1 (VP16-accessory protein)	1896					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GATTTTAATGGCACAAGGGGC	0.592000													97	11					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38783895	38783895	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:38783895G>A	ENST00000449082.2	-	13	1992	c.1993C>T	c.(1993-1995)Ccc>Tcc	p.P665S		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	665					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TCTGCAAAGGGATCCGTCACA	0.537000													13	23					0	0	1	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45555832	45555832	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr18:45555832C>T	ENST00000588982.1	-	4	2160	c.1659G>A	c.(1657-1659)gaG>gaA	p.E553E	ZBTB7C_ENST00000590800.1_Silent_p.E553E|ZBTB7C_ENST00000535628.2_Silent_p.E553E|ZBTB7C_ENST00000586438.1_Silent_p.E553E|ZBTB7C_ENST00000332053.2_Silent_p.E553E			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	553						intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						TCATCTGTGTCTCCTCGAACT	0.726000													15	6					0	0	1	0	0
KCNQ4	9132	broad.mit.edu	37	1	41285929	41285929	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:41285929C>T	ENST00000347132.5	+	7	1120	c.1038C>T	c.(1036-1038)atC>atT	p.I346I	KCNQ4_ENST00000506017.1_3'UTR|KCNQ4_ENST00000509682.2_Silent_p.I346I	NM_004700.3|NM_172163.2	NP_004691.2|NP_751895.1	P56696	KCNQ4_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 4	346					sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(13)|skin(1)	26	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			CCAACCTCATCCAGGTACAAG	0.622000													16	2					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5848555	5848555	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:5848555G>A	ENST00000546188.1	-	13	1424	c.1353C>T	c.(1351-1353)ttC>ttT	p.F451F	ANO2_ENST00000538154.1_5'UTR|ANO2_ENST00000356134.5_Silent_p.F451F|ANO2_ENST00000327087.8_Silent_p.F450F			Q9NQ90	ANO2_HUMAN	anoctamin 2	455						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						AGTTTTCCAGGAACATGGTAG	0.438000													4	8					0	0	1	0	0
C7orf57	136288	broad.mit.edu	37	7	48092411	48092411	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:48092411G>A	ENST00000348904.3	+	7	932	c.720G>A	c.(718-720)aaG>aaA	p.K240K	C7orf57_ENST00000420324.1_Silent_p.K269K|C7orf57_ENST00000435376.1_Silent_p.K102K|C7orf57_ENST00000430738.1_Silent_p.K285K|C7orf57_ENST00000539619.1_Silent_p.K240K	NM_001100159.2	NP_001093629.1	Q8NEG2	CG057_HUMAN	chromosome 7 open reading frame 57	240										breast(1)|endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	9						GGACCCCGAAGACCTCCAGGG	0.537000													16	25					0	0	1	0	0
FAM71E1	112703	broad.mit.edu	37	19	50979171	50979171	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:50979171G>A	ENST00000600100.1	-	2	643	c.279C>T	c.(277-279)ccC>ccT	p.P93P	FAM71E1_ENST00000595790.1_Silent_p.P93P			Q6IPT2	F71E1_HUMAN	family with sequence similarity 71, member E1	93										breast(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.0077)|GBM - Glioblastoma multiforme(134;0.026)		GGAGCCGTCTGGGACGGCCCG	0.612000													10	11					0	0	1	0	0
RASGRP1	10125	broad.mit.edu	37	15	38786918	38786918	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr15:38786918C>T	ENST00000310803.5	-	16	2101	c.1924G>A	c.(1924-1926)Ggt>Agt	p.G642S	RASGRP1_ENST00000539159.1_Missense_Mutation_p.G594S|RASGRP1_ENST00000561180.1_Missense_Mutation_p.G693S|RASGRP1_ENST00000450598.2_Missense_Mutation_p.G607S|RASGRP1_ENST00000558164.1_Intron|RASGRP1_ENST00000559830.1_Intron	NM_001128602.1|NM_005739.3	NP_001122074.1|NP_005730.2	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	642					cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		CTCTCCTCACCATGTTCCACA	0.517000													12	2					0	0	1	0	0
VPS33A	65082	broad.mit.edu	37	12	122716889	122716889	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:122716889G>A	ENST00000267199.4	-	13	1807	c.1695C>T	c.(1693-1695)tcC>tcT	p.S565S	RP11-512M8.5_ENST00000535844.1_Silent_p.S526S	NM_022916.4	NP_075067.2	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33 homolog A (S. cerevisiae)	565					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	28	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		CTTCCAACTGGGAGAGAAATC	0.438000													32	74					0	0	1	0	0
EIF2S3	1968	broad.mit.edu	37	X	24089794	24089794	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:24089794C>T	ENST00000253039.4	+	10	1385	c.1132C>T	c.(1132-1134)Ctt>Ttt	p.L378F		NM_001415.3	NP_001406.1	P41091	IF2G_HUMAN	eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa	378						cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(1)|lung(4)|ovary(1)	12						CTATTTCCTGCTTAGACGGCT	0.438000													42	8					0	0	1	0	0
TNNI3K	51086	broad.mit.edu	37	1	75005965	75005965	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:75005965G>A	ENST00000370891.2	+	26	2718	c.2702G>A	c.(2701-2703)aGa>aAa	p.R901K	FPGT-TNNI3K_ENST00000557284.1_Missense_Mutation_p.R901K|TNNI3K_ENST00000326637.3_Missense_Mutation_p.R800K|TNNI3K_ENST00000465473.1_3'UTR	NM_001112808.2	NP_001106279.1			TNNI3 interacting kinase											cervix(1)|endometrium(3)|kidney(5)|large_intestine(21)|lung(31)|ovary(4)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	76						GAGATGAAAAGAAGTCTTCAA	0.358000													38	13					0	0	1	0	0
TANC1	85461	broad.mit.edu	37	2	160007008	160007008	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:160007008C>T	ENST00000263635.6	+	7	860	c.623C>T	c.(622-624)cCc>cTc	p.P208L	TANC1_ENST00000454300.1_Intron	NM_001145909.1|NM_033394.2	NP_001139381.1|NP_203752.2	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	208	Ser-rich.					cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						AACAAAAGTCCCTGTGAGACC	0.512000													5	42					0	0	1	0	0
POU6F1	5463	broad.mit.edu	37	12	51589802	51589802	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:51589802G>A	ENST00000389243.4	-	8	1139	c.200C>T	c.(199-201)cCt>cTt	p.P67L	POU6F1_ENST00000333640.10_Missense_Mutation_p.P67L|POU6F1_ENST00000550824.1_Missense_Mutation_p.P67L			Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	67	Gln/Pro-rich.				brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)	11						GACAGCCACAGGTGGAGGCAG	0.672000													7	8					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159682250	159682250	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:159682250C>T	ENST00000297267.9	+	19	5403	c.5203C>T	c.(5203-5205)Cct>Tct	p.P1735S	FNDC1_ENST00000340366.6_Missense_Mutation_p.P1672S	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1735	Fibronectin type-III 5.					extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		AGCACAAAATCCTCATGGCTA	0.358000													10	23					0	0	1	0	0
OR2B6	26212	broad.mit.edu	37	6	27925809	27925809	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:27925809C>T	ENST00000244623.1	+	1	791	c.791C>T	c.(790-792)tCg>tTg	p.S264L		NM_012367.1	NP_036499.1	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B, member 6	264					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CAACCACCTTCGCCCAGCTCC	0.453000													17	123					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123846349	123846349	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:123846349C>T	ENST00000369005.1	+	4	4674	c.4334C>T	c.(4333-4335)cCa>cTa	p.P1445L	TACC2_ENST00000515273.1_Missense_Mutation_p.P1445L|TACC2_ENST00000453444.2_Missense_Mutation_p.P1445L|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000358010.1_Intron|TACC2_ENST00000515603.1_Missense_Mutation_p.P1445L|TACC2_ENST00000334433.3_Missense_Mutation_p.P1445L	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	1445						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CTCACCAGGCCATTGGGCCCA	0.587000													10	6					0	0	1	0	0
RFX3	5991	broad.mit.edu	37	9	3330272	3330272	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:3330272G>A	ENST00000382004.3	-	5	772	c.461C>T	c.(460-462)gCc>gTc	p.A154V	RFX3_ENST00000302303.1_Missense_Mutation_p.A154V|RFX3_ENST00000358730.2_Missense_Mutation_p.A154V	NM_134428.1	NP_602304.1	P48380	RFX3_HUMAN	regulatory factor X, 3 (influences HLA class II expression)	154					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(11)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		CGCTGGGGAGGCCCGAGTTGT	0.433000													10	24					0	0	1	0	0
GPAM	57678	broad.mit.edu	37	10	113919767	113919767	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:113919767G>A	ENST00000348367.4	-	17	2001	c.1804C>T	c.(1804-1806)Ccc>Tcc	p.P602S	GPAM_ENST00000369425.1_Missense_Mutation_p.P602S|GPAM_ENST00000423155.1_Missense_Mutation_p.P602S			Q9HCL2	GPAT1_HUMAN	glycerol-3-phosphate acyltransferase, mitochondrial	602					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			breast(2)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Epithelial(162;0.0306)|all cancers(201;0.123)		GTGCTAGTGGGACCCCCCAGT	0.522000													33	13					0	0	1	0	0
ERVW-1	30816	broad.mit.edu	37	7	92098627	92098627	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:92098627C>T	ENST00000493463.2	-	1	1992	c.1069G>A	c.(1069-1071)Gac>Aac	p.D357N	AC007566.10_ENST00000427458.1_RNA|ERVW-1_ENST00000604270.1_Intron|ERVW-1_ENST00000603053.1_Missense_Mutation_p.D357N	NM_014590.3	NP_055405.3	Q9UQF0	ENW1_HUMAN		357					syncytium formation	integral to membrane|plasma membrane|virion				endometrium(1)|large_intestine(1)|lung(15)	17						cgttccatgtccccatttagt	0.473000													22	63					0	0	1	0	0
DEPDC4	120863	broad.mit.edu	37	12	100660801	100660801	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:100660801C>T	ENST00000416321.1	-	1	56	c.54G>A	c.(52-54)ccG>ccA	p.P18P		NM_152317.2	NP_689530.1	Q8N2C3	DEPD4_HUMAN	DEP domain containing 4	18					intracellular signal transduction					NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)|urinary_tract(1)	15						TACGGAACCTCGGAGTCAAAA	0.627000													30	39					0	0	1	0	0
NUP62	23636	broad.mit.edu	37	19	50412606	50412606	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:50412606G>A	ENST00000596217.1	-	2	2346	c.459C>T	c.(457-459)acC>acT	p.T153T	NUP62_ENST00000352066.3_Silent_p.T153T|IL4I1_ENST00000595948.1_Intron|NUP62_ENST00000422090.2_Silent_p.T153T|NUP62_ENST00000597029.1_Silent_p.T153T|NUP62_ENST00000413454.1_Silent_p.T153T|IL4I1_ENST00000341114.3_Intron|NUP62_ENST00000597723.1_Silent_p.T153T			P37198	NUP62_HUMAN	nucleoporin 62kDa	153	15 X 9 AA approximate repeats.|Thr-rich.				carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|stomach(1)|urinary_tract(2)	19		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		CTCCAGATGTGGTAGCTGGAG	0.602000													15	37					0	0	1	0	0
CHD3	1107	broad.mit.edu	37	17	7802801	7802801	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:7802801G>T	ENST00000380358.4	+	15	2662	c.2661G>T	c.(2659-2661)gaG>gaT	p.E887D	CHD3_ENST00000330494.7_Missense_Mutation_p.E828D|CHD3_ENST00000358181.4_Missense_Mutation_p.E828D	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	828	Helicase ATP-binding.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				TCATTCGTGAGAATGAATTCT	0.488000													118	26					6.59513e-52	6.73802e-52	1	1	0
AGRN	375790	broad.mit.edu	37	1	984698	984698	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:984698C>T	ENST00000379370.2	+	25	4431	c.4381C>T	c.(4381-4383)Cgg>Tgg	p.R1461W		NM_198576.3	NP_940978.2	O00468	AGRIN_HUMAN	agrin	1461	Laminin G-like 1.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		GGAGCTGTCCCGGCACTGGCG	0.687000													10	30					0	0	1	0	0
CA14	23632	broad.mit.edu	37	1	150235700	150235700	+	Silent	SNP	G	G	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:150235700G>T	ENST00000369111.4	+	8	1693	c.723G>T	c.(721-723)ctG>ctT	p.L241L		NM_012113.1	NP_036245.1	Q9ULX7	CAH14_HUMAN	carbonic anhydrase XIV	241						integral to membrane	carbonate dehydratase activity|metal ion binding			central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|prostate(2)	18	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CTCCTCAGCTGGAAAAGCTTC	0.527000													13	106					3.27435e-08	3.30385e-08	1	1	0
PIP4K2A	5305	broad.mit.edu	37	10	22898640	22898640	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:22898640C>T	ENST00000376573.4	-	2	379	c.151G>A	c.(151-153)Gaa>Aaa	p.E51K	PIP4K2A_ENST00000422321.1_5'UTR|PIP4K2A_ENST00000545335.1_5'UTR	NM_005028.4	NP_005019.2	P48426	PI42A_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	51	PIPK.						1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding			endometrium(4)|kidney(13)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	29						TGGCTCAGTTCATTGATCTGG	0.358000													27	14					0	0	1	0	0
CLU	1191	broad.mit.edu	37	8	27462705	27462705	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:27462705C>T	ENST00000316403.10	-	5	970	c.565G>A	c.(565-567)Gag>Aag	p.E189K	CLU_ENST00000560366.1_Missense_Mutation_p.E241K|CLU_ENST00000405140.3_Missense_Mutation_p.E189K|CLU_ENST00000546343.1_Missense_Mutation_p.E200K|CLU_ENST00000523500.1_Missense_Mutation_p.E189K			P10909	CLUS_HUMAN	clusterin	189					chaperone-mediated protein folding|complement activation, classical pathway|innate immune response|lipid metabolic process|negative regulation of apoptosis|negative regulation of protein homooligomerization|platelet activation|platelet degranulation|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|response to misfolded protein|response to virus|reverse cholesterol transport	chromaffin granule|cytosol|endoplasmic reticulum|microsome|mitochondrial membrane|nucleus|perinuclear region of cytoplasm|platelet alpha granule lumen|spherical high-density lipoprotein particle	misfolded protein binding|ubiquitin protein ligase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)	21		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|Colorectal(74;0.132)		TGGAAGAGCTCGTCTATGATG	0.607000													23	25					0	0	1	0	0
KRBA1	84626	broad.mit.edu	37	7	149419622	149419622	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:149419622G>A	ENST00000255992.10	+	6	975	c.576G>A	c.(574-576)caG>caA	p.Q192Q	KRBA1_ENST00000485033.2_Silent_p.Q192Q|KRBA1_ENST00000319551.8_Silent_p.Q192Q|KRBA1_ENST00000479560.1_3'UTR	NM_032534.2	NP_115923.2	A5PL33	KRBA1_HUMAN	KRAB-A domain containing 1	192										breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(17)|ovary(1)|prostate(1)	27	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ACAGAGGACAGGAGAGAGGGA	0.632000													4	6					0	0	1	0	0
CHRM3	1131	broad.mit.edu	37	1	240071520	240071520	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:240071520G>A	ENST00000255380.4	+	5	1548	c.769G>A	c.(769-771)Gaa>Aaa	p.E257K		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	257					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	GATCTATAAGGAAACTGAAAA	0.483000													60	23					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139164168	139164168	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:139164168C>T	ENST00000395297.1	-	13	2720	c.2550G>A	c.(2548-2550)ggG>ggA	p.G850G		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	850										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GCTTCCCTTTCCCTTTGGGGA	0.488000										HNSCC(54;0.14)			29	43					0	0	1	0	0
ERBB3	2065	broad.mit.edu	37	12	56495343	56495343	+	Missense_Mutation	SNP	C	C	T	rs67708249		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:56495343C>T	ENST00000267101.3	+	28	3973	c.3533C>T	c.(3532-3534)tCt>tTt	p.S1178F	ERBB3_ENST00000415288.2_Missense_Mutation_p.S1119F|RP11-603J24.9_ENST00000548861.1_Intron|ERBB3_ENST00000549832.1_Missense_Mutation_p.S298F|ERBB3_ENST00000450146.2_Missense_Mutation_p.S535F|ERBB3_ENST00000553131.1_Missense_Mutation_p.S419F	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	1178					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			GGCACCCTTTCTTCAGTGGGT	0.488000													11	44					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28543494	28543494	+	Silent	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:28543494A>G	ENST00000452236.2	-	3	1605	c.988T>C	c.(988-990)Tta>Cta	p.L330L		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	330					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						TTCGCTTGTAACTCTTTCTCC	0.373000													101	62					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20257933	20257933	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:20257933G>C	ENST00000245957.5	+	22	2703	c.2627G>C	c.(2626-2628)tGc>tCc	p.C876S	C20orf26_ENST00000377309.2_Missense_Mutation_p.C232S	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	876										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		ACCATCACCTGCATCAACAAC	0.627000													54	38					0	0	1	0	0
QSOX2	169714	broad.mit.edu	37	9	139118626	139118626	+	Silent	SNP	G	G	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:139118626G>T	ENST00000358701.5	-	2	460	c.423C>A	c.(421-423)acC>acA	p.T141T		NM_181701.3	NP_859052.3	Q6ZRP7	QSOX2_HUMAN	quiescin Q6 sulfhydryl oxidase 2	141	Thioredoxin.				cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)	22		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)		TCACCCGGAAGGTGGGGTAGA	0.562000											OREG0019616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	79					6.02846e-25	6.14155e-25	1	1	0
PADI2	11240	broad.mit.edu	37	1	17397977	17397977	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:17397977C>T	ENST00000375486.4	-	14	1622	c.1559G>A	c.(1558-1560)gGg>gAg	p.G520E	PADI2_ENST00000444885.2_Missense_Mutation_p.G404E|PADI2_ENST00000466151.1_5'UTR	NM_007365.2	NP_031391.2	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	520					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(12)|ovary(4)|pancreas(1)|skin(5)|urinary_tract(3)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	GCTGCTCATCCCACCCAAGCC	0.562000													47	14					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92615919	92615919	+	Silent	SNP	C	C	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:92615919C>A	ENST00000298047.6	+	23	12314	c.12297C>A	c.(12295-12297)atC>atA	p.I4099I	FAT3_ENST00000533797.1_Silent_p.I434I|FAT3_ENST00000409404.2_Silent_p.I4099I|FAT3_ENST00000525166.1_Silent_p.I3949I			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4099	EGF-like 4; calcium-binding (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGGAGGACATCAATGAGTGCG	0.587000										TCGA Ovarian(4;0.039)			5	11					0.217242	0.217364	1	1	0
IRGC	56269	broad.mit.edu	37	19	44223753	44223753	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:44223753C>T	ENST00000244314.5	+	2	1242	c.1043C>T	c.(1042-1044)tCc>tTc	p.S348F		NM_019612.3	NP_062558.1	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	348						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(2)	25		Prostate(69;0.0435)				CGGCTCTATTCCCAGTCGTCC	0.672000													22	27					0	0	1	0	0
PLBD1	79887	broad.mit.edu	37	12	14656776	14656776	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:14656776T>G	ENST00000240617.5	-	11	2244	c.1592A>C	c.(1591-1593)cAg>cCg	p.Q531P		NM_024829.5	NP_079105.4	Q6P4A8	PLBL1_HUMAN	phospholipase B domain containing 1	531					lipid catabolic process	extracellular region	hydrolase activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	16						TGGCATGCCCTGATGTAGAGT	0.428000													16	55					0	0	1	0	0
KCNA5	3741	broad.mit.edu	37	12	5154927	5154927	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:5154927G>A	ENST00000252321.3	+	1	1843	c.1614G>A	c.(1612-1614)gaG>gaA	p.E538E		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	538						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						TTAAGGAAGAGCAGGGCACTC	0.627000													12	23					0	0	1	0	0
SCML2	10389	broad.mit.edu	37	X	18265917	18265917	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:18265917G>A	ENST00000251900.4	-	12	1701	c.1542C>T	c.(1540-1542)ctC>ctT	p.L514L	SCML2_ENST00000398048.3_Silent_p.L250L	NM_006089.2	NP_006080.1	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2 (Drosophila)	514					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	36	Hepatocellular(33;0.183)					TTGTTTTGGGGAGCTTAGGAG	0.423000													18	8					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41646618	41646618	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:41646618G>A	ENST00000313860.7	+	10	1127	c.1073G>A	c.(1072-1074)aGg>aAg	p.R358K	LIMCH1_ENST00000381753.4_Missense_Mutation_p.R192K|LIMCH1_ENST00000508501.1_Missense_Mutation_p.R358K|LIMCH1_ENST00000396595.3_Missense_Mutation_p.R204K|LIMCH1_ENST00000513024.1_Missense_Mutation_p.R187K|LIMCH1_ENST00000509277.1_Missense_Mutation_p.R192K|LIMCH1_ENST00000511496.1_Missense_Mutation_p.R199K|LIMCH1_ENST00000514096.1_Missense_Mutation_p.R199K|LIMCH1_ENST00000512946.1_Missense_Mutation_p.R358K|LIMCH1_ENST00000503057.1_Missense_Mutation_p.R743K|LIMCH1_ENST00000512632.1_Missense_Mutation_p.R358K|LIMCH1_ENST00000512820.1_Missense_Mutation_p.R346K	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	358					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						AACCAGCTGAGGGAAGAGGAC	0.622000											OREG0016169	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	9					0	0	1	0	0
XPNPEP2	7512	broad.mit.edu	37	X	128877993	128877993	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:128877993G>A	ENST00000371106.3	+	3	372	c.180G>A	c.(178-180)caG>caA	p.Q60Q	XPNPEP2_ENST00000371105.3_Silent_p.Q60Q	NM_003399.5	NP_003390.4	O43895	XPP2_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound	60					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity			endometrium(3)|kidney(3)|large_intestine(5)|liver(1)|lung(20)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	37						TCCGCCAGCAGATGCAGACCC	0.507000													69	15					0	0	1	0	0
SON	6651	broad.mit.edu	37	21	34924275	34924275	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr21:34924275C>T	ENST00000356577.4	+	3	3213	c.2738C>T	c.(2737-2739)cCc>cTc	p.P913L	SON_ENST00000290239.6_Missense_Mutation_p.P913L|SON_ENST00000381679.4_Missense_Mutation_p.P913L|SON_ENST00000381692.2_Intron|SON_ENST00000300278.4_Missense_Mutation_p.P913L	NM_138927.1	NP_620305.1	P18583	SON_HUMAN	SON DNA binding protein	913	11 X 7 AA tandem repeats of [DR]-P-Y-R- [LI][AG][QHP].				anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding	p.P913L(1)		breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						TCTCCTGATCCCTATAGGTTA	0.468000													8	12					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179612348	179612348	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:179612348C>T	ENST00000360870.5	-	46	15001	c.14779G>A	c.(14779-14781)Gca>Aca	p.A4927T	TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000590773.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	1054	Ig-like 29.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAAGCTTTGCCTGGTCTCTG	0.438000													52	34					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41446972	41446972	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr21:41446972C>T	ENST00000400454.1	-	27	5357	c.4880G>A	c.(4879-4881)aGg>aAg	p.R1627K		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1627					cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				ACCTCGCAGCCTCTTTAGCCT	0.602000													4	15					0	0	1	0	0
ACOX2	8309	broad.mit.edu	37	3	58519227	58519227	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:58519227C>T	ENST00000302819.5	-	5	819	c.528G>A	c.(526-528)caG>caA	p.Q176Q	ACOX2_ENST00000459701.2_Silent_p.Q176Q	NM_003500.3	NP_003491.1	Q99424	ACOX2_HUMAN	acyl-CoA oxidase 2, branched chain	176					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(3)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		TCACAAACTCCTGGGTGGCTG	0.537000											OREG0015638	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	37					0	0	1	0	0
TCERG1	10915	broad.mit.edu	37	5	145834772	145834772	+	Silent	SNP	T	T	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:145834772T>A	ENST00000296702.5	+	2	251	c.213T>A	c.(211-213)ccT>ccA	p.P71P	TCERG1_ENST00000394421.2_Silent_p.P71P	NM_006706.3	NP_006697.2	O14776	TCRG1_HUMAN	transcription elongation regulator 1	71	Pro-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(18)|lung(9)|ovary(2)|prostate(3)|skin(1)	46		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GACGTCCTCCTTTTGATCCTA	0.572000													63	31					0	0	1	0	0
SLC6A6	6533	broad.mit.edu	37	3	14513751	14513751	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:14513751A>T	ENST00000454876.2	+	10	1464	c.1135A>T	c.(1135-1137)Aca>Tca	p.T379S	SLC6A6_ENST00000360861.3_Missense_Mutation_p.T379S			P31641	SC6A6_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 6	379					cellular amino acid metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(2)	28						AAAAGCTGTGACAATGATGCC	0.532000													12	32					0	0	1	0	0
EPB41L1	2036	broad.mit.edu	37	20	34763556	34763556	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:34763556C>T	ENST00000338074.2	+	3	422	c.261C>T	c.(259-261)ccC>ccT	p.P87P	EPB41L1_ENST00000441639.1_Silent_p.P25P|EPB41L1_ENST00000373941.1_Silent_p.P87P|EPB41L1_ENST00000202028.5_Silent_p.P25P|EPB41L1_ENST00000373950.2_Silent_p.P25P|EPB41L1_ENST00000373946.3_Silent_p.P56P	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	87					cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					AGAAATCGCCCCAGAAGATTG	0.572000													8	68					0	0	1	0	0
ZNF888	388559	broad.mit.edu	37	19	53421117	53421117	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:53421117G>A	ENST00000596623.1	-	0	235									zinc finger protein 888																		CTCACCTGAGGAAGAGCCATC	0.438000													35	15					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63447818	63447818	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:63447818G>A	ENST00000322893.7	-	6	982	c.714C>T	c.(712-714)ttC>ttT	p.F238F	KCNH5_ENST00000420622.2_Silent_p.F238F|KCNH5_ENST00000394964.2_Silent_p.F180F|KCNH5_ENST00000394968.1_Silent_p.F180F	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	238					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		GCTTTGTTTTGAAGGAAACAT	0.363000													27	21					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152510568	152510568	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:152510568C>T	ENST00000427231.2	-	52	7055	c.6853G>A	c.(6853-6855)Gat>Aat	p.D2285N	NEB_ENST00000409198.1_Missense_Mutation_p.D2285N|NEB_ENST00000603639.1_Missense_Mutation_p.D2285N|NEB_ENST00000397345.3_Missense_Mutation_p.D2285N|NEB_ENST00000604864.1_Missense_Mutation_p.D2285N|NEB_ENST00000172853.10_Missense_Mutation_p.D2285N	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	2285					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		ACTGGGAGATCATAGCCTTTC	0.323000													6	31					0	0	1	0	0
IFNA4	3441	broad.mit.edu	37	9	21187354	21187354	+	Silent	SNP	G	G	A	rs147890478		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:21187354G>A	ENST00000421715.1	-	1	244	c.177C>T	c.(175-177)ttC>ttT	p.F59F		NM_021068.2	NP_066546.1	P05014	IFNA4_HUMAN	interferon, alpha 4	59					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding	p.F59F(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	17				GBM - Glioblastoma multiforme(5;2.69e-202)|Lung(24;2.26e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		CGGGGAATCCGAAATCATGTC	0.517000													31	85					0	0	1	0	0
FANCM	57697	broad.mit.edu	37	14	45665628	45665628	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:45665628G>A	ENST00000267430.5	+	21	5679	c.5594G>A	c.(5593-5595)aGg>aAg	p.R1865K	FANCM_ENST00000542564.2_Missense_Mutation_p.R1839K	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1865	Interaction with FAAP24 and EME1.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding	p.R1865M(1)		breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						GTGGTGGAAAGGAGGTCTCAA	0.398000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				54	37					0	0	1	0	0
WDR64	128025	broad.mit.edu	37	1	241904893	241904893	+	Missense_Mutation	SNP	G	G	A	rs150454119		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:241904893G>A	ENST00000366552.2	+	11	1574	c.1367G>A	c.(1366-1368)cGa>cAa	p.R456Q	WDR64_ENST00000437684.2_Missense_Mutation_p.R456Q	NM_144625.4	NP_653226.4	B1ANS9	WDR64_HUMAN	WD repeat domain 64	456										breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(17)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			ACTCATGAACGAGAAATCAAT	0.358000													33	20					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34554618	34554618	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:34554618C>T	ENST00000373381.4	-	2	540	c.364G>A	c.(364-366)Gtg>Atg	p.V122M		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	82	CUB 1.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCATCAAACACCGACAGGACA	0.557000													27	18					0	0	1	0	0
ENPP6	133121	broad.mit.edu	37	4	185018424	185018424	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:185018424C>T	ENST00000296741.2	-	7	1232	c.1091G>A	c.(1090-1092)cGg>cAg	p.R364Q		NM_153343.3	NP_699174.1	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 6	364					lipid catabolic process	extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	15		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		GAAGATGCCCCGCATGTCCAT	0.592000													41	30					0	0	1	0	0
TMEM175	84286	broad.mit.edu	37	4	941906	941906	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:941906C>T	ENST00000264771.4	+	3	341	c.156C>T	c.(154-156)atC>atT	p.I52I	TMEM175_ENST00000515740.1_Intron|TMEM175_ENST00000508204.1_Intron	NM_032326.2	NP_115702.1	Q9BSA9	TM175_HUMAN	transmembrane protein 175	52						integral to membrane				NS(1)|endometrium(1)|large_intestine(2)|lung(6)|pancreas(1)|upper_aerodigestive_tract(3)	14			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			CCCCTCAGATCCTGCCTGTGA	0.622000													19	49					0	0	1	0	0
ZNF214	7761	broad.mit.edu	37	11	7021188	7021188	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:7021188G>A	ENST00000278314.4	-	3	2041	c.1726C>T	c.(1726-1728)Cat>Tat	p.H576Y	ZNF214_ENST00000536068.1_Missense_Mutation_p.H576Y	NM_013249.2	NP_037381.2	Q9UL59	ZN214_HUMAN	zinc finger protein 214	576					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		TCTCCTGCATGGACTCTTTGA	0.368000													21	19					0	0	1	0	0
TSPAN18	90139	broad.mit.edu	37	11	44940819	44940819	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:44940819G>A	ENST00000340160.3	+	6	627	c.388G>A	c.(388-390)Gac>Aac	p.D130N	TSPAN18_ENST00000520358.2_Missense_Mutation_p.D130N	NM_130783.4	NP_570139.3	Q96SJ8	TSN18_HUMAN	tetraspanin 18	130						integral to membrane				endometrium(1)|large_intestine(6)|lung(3)	10						GGGCAATAACGACACAGACGT	0.557000													9	30					0	0	1	0	0
TAS2R4	50832	broad.mit.edu	37	7	141478805	141478805	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:141478805G>A	ENST00000247881.2	+	1	564	c.517G>A	c.(517-519)Ggc>Agc	p.G173S	SSBP1_ENST00000465582.1_Intron	NM_016944.1	NP_058640.1	Q9NYW5	TA2R4_HUMAN	taste receptor, type 2, member 4	173					sensory perception of taste	cilium membrane	taste receptor activity			endometrium(1)|large_intestine(4)|lung(2)	7	Melanoma(164;0.0171)			BRCA - Breast invasive adenocarcinoma(188;0.196)		TATCAGTGAGGGCATCTTGTC	0.423000													76	88					0	0	1	0	0
ABCA1	19	broad.mit.edu	37	9	107581983	107581983	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:107581983G>A	ENST00000374736.3	-	22	3519	c.3125C>T	c.(3124-3126)tCt>tTt	p.S1042F		NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	1042	ABC transporter 1.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CAAGGCCACAGATAGCTTTCT	0.547000													19	38					0	0	1	0	0
LNPEP	4012	broad.mit.edu	37	5	96315573	96315573	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:96315573C>T	ENST00000231368.5	+	2	1443	c.751C>T	c.(751-753)Ctt>Ttt	p.L251F	LNPEP_ENST00000395770.3_Missense_Mutation_p.L237F	NM_005575.2	NP_005566.2	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase	251					cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	34		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		CCCCGAAGCCCTTCTAGCAGG	0.413000													18	3					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76395465	76395465	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:76395465C>T	ENST00000357063.3	+	15	3776	c.2516C>T	c.(2515-2517)cCt>cTt	p.P839L	LMO7_ENST00000526202.1_Missense_Mutation_p.P404L|LMO7_ENST00000321797.8_Missense_Mutation_p.P554L|LMO7_ENST00000377534.3_Missense_Mutation_p.P839L|LMO7_ENST00000341547.4_Missense_Mutation_p.P505L|LMO7_ENST00000465261.2_Missense_Mutation_p.P554L			Q8WWI1	LMO7_HUMAN	LIM domain 7	839						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		GCAACTTATCCTTCAGAAATT	0.433000													13	19					0	0	1	0	0
LGSN	51557	broad.mit.edu	37	6	63990680	63990680	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:63990680G>A	ENST00000370657.4	-	4	809	c.776C>T	c.(775-777)tCc>tTc	p.S259F	LGSN_ENST00000370658.5_Intron			Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase domain	259					glutamine biosynthetic process		glutamate-ammonia ligase activity			NS(1)|endometrium(2)|large_intestine(5)|lung(16)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	34					L-Glutamic Acid(DB00142)	CCTGGTAGAGGAGGAAAAACT	0.433000													11	12					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186544650	186544650	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:186544650G>A	ENST00000431808.1	-	14	2484	c.1921C>T	c.(1921-1923)Cac>Tac	p.H641Y	SORBS2_ENST00000355634.5_Missense_Mutation_p.H741Y|SORBS2_ENST00000448662.2_Intron|SORBS2_ENST00000284776.7_Missense_Mutation_p.H641Y|SORBS2_ENST00000319471.9_Intron|SORBS2_ENST00000418609.1_Missense_Mutation_p.H545Y|SORBS2_ENST00000449407.2_Intron|SORBS2_ENST00000498125.1_Intron|SORBS2_ENST00000393528.3_Intron|SORBS2_ENST00000437304.2_Intron			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	641	His-rich.					actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		tggtggtggtggtggCTGGAT	0.517000													29	14					0	0	1	0	0
TADA2B	93624	broad.mit.edu	37	4	7056685	7056685	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:7056685C>T	ENST00000310074.7	+	2	1356	c.1167C>T	c.(1165-1167)tcC>tcT	p.S389S	TADA2B_ENST00000512388.1_Silent_p.S314S|TADA2B_ENST00000515646.1_Silent_p.S297S	NM_152293.2	NP_689506.2	Q86TJ2	TAD2B_HUMAN	transcriptional adaptor 2B	389					regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|zinc ion binding			breast(3)|endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)	18						GAATCCCCTCCAAAAGCCGCC	0.488000													18	42					0	0	1	0	0
PIH1D1	55011	broad.mit.edu	37	19	49949662	49949662	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:49949662G>A	ENST00000262265.5	-	9	1085	c.850C>T	c.(850-852)Ccg>Tcg	p.P284S	PIH1D1_ENST00000602226.1_5'UTR|PIH1D1_ENST00000596049.1_Missense_Mutation_p.P284S	NM_017916.2	NP_060386.1	Q9NWS0	PIHD1_HUMAN	PIH1 domain containing 1	284					box C/D snoRNP assembly	pre-snoRNP complex				NS(1)|breast(1)|kidney(1)|large_intestine(2)|lung(5)|urinary_tract(1)	11		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00152)|GBM - Glioblastoma multiforme(486;0.0244)		GGCAGAAGCGGCATGGCCACC	0.522000													3	30					0	0	1	0	0
RECQL4	9401	broad.mit.edu	37	8	145738661	145738661	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:145738661G>A	ENST00000428558.2	-	15	2444	c.2403C>T	c.(2401-2403)gcC>gcT	p.A801A	CTD-2517M22.17_ENST00000580385.1_RNA|RECQL4_ENST00000532237.1_5'UTR	NM_004260.3	NP_004251.3	O94761	RECQ4_HUMAN	RecQ protein-like 4	801	Helicase C-terminal.				DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	26	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CCCGGCCCACGGCCTGCACGT	0.721000			"""N, F, S"""			"""osteosarcoma, skin basal and sqamous cell"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Rothmund-Thomson syndrome;RAPADILINO syndrome;Baller-Gerold syndrome				12	15					0	0	1	0	0
NLRC3	197358	broad.mit.edu	37	16	3614473	3614473	+	RNA	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:3614473C>T	ENST00000301749.7	-	0	870				NLRC3_ENST00000359128.5_RNA|NLRC3_ENST00000603507.1_RNA|NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000419350.2_RNA|NLRC3_ENST00000324659.8_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CGAAGTGCCTCACCAGGGTGG	0.657000													28	44					0	0	1	0	0
CFAP54	144535	broad.mit.edu	37	12	97102502	97102502	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:97102502G>A	ENST00000524981.3	+	15	1998	c.1998G>A	c.(1996-1998)gcG>gcA	p.A666A				Q6ZTY8	CL063_HUMAN		640			E -> K (in dbSNP:rs7968231).							breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						GTGTGGCTGCGACAATAAATT	0.338000													12	35					0	0	1	0	0
SYT9	143425	broad.mit.edu	37	11	7335110	7335110	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:7335110C>T	ENST00000318881.6	+	3	1219	c.982C>T	c.(982-984)Cta>Tta	p.L328L	SYT9_ENST00000396716.2_Silent_p.L296L	NM_175733.3	NP_783860.1	Q86SS6	SYT9_HUMAN	synaptotagmin IX	328						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(2)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	38				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		GGATCACTTCCTAGACTTGGC	0.478000													61	55					0	0	1	0	0
INHBA	3624	broad.mit.edu	37	7	41729504	41729504	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:41729504G>A	ENST00000242208.4	-	3	1271	c.1025C>T	c.(1024-1026)cCc>cTc	p.P342L	AC005027.3_ENST00000416150.1_RNA|INHBA_ENST00000464515.1_5'UTR|INHBA_ENST00000442711.1_Missense_Mutation_p.P342L	NM_002192.2	NP_002183.1	P08476	INHBA_HUMAN	inhibin, beta A	342					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(15)|lung(26)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						ATAGCCAGAGGGAGCAATGAT	0.537000										TSP Lung(11;0.080)			37	41					0	0	1	0	0
STXBP2	6813	broad.mit.edu	37	19	7712101	7712101	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:7712101C>T	ENST00000441779.2	+	17	1576	c.1539C>T	c.(1537-1539)ccC>ccT	p.P513P	STXBP2_ENST00000414284.2_Silent_p.P499P|STXBP2_ENST00000221283.5_Silent_p.P502P|STXBP2_ENST00000602355.1_Silent_p.P37P	NM_001272034.1	NP_001258963.1	Q15833	STXB2_HUMAN	syntaxin binding protein 2	502					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	23						TATCCGACCCCGCCCCCACGG	0.741000													26	30					0	0	1	0	0
ITGB4	3691	broad.mit.edu	37	17	73744963	73744963	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:73744963G>A	ENST00000200181.3	+	27	3340	c.3153G>A	c.(3151-3153)ggG>ggA	p.G1051G	ITGB4_ENST00000449880.2_Silent_p.G1051G|ITGB4_ENST00000339591.3_Silent_p.G1051G|ITGB4_ENST00000579662.1_Silent_p.G1051G|ITGB4_ENST00000450894.3_Silent_p.G1051G	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	1051	Calx-beta.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			TCCAGCCTGGGGAGGCCTGGA	0.647000													9	7					0	0	1	0	0
LTBP3	4054	broad.mit.edu	37	11	65321712	65321712	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:65321712G>A	ENST00000301873.5	-	2	739	c.471C>T	c.(469-471)ggC>ggT	p.G157G	LTBP3_ENST00000322147.4_Silent_p.G157G|LTBP3_ENST00000536982.1_Intron	NM_001130144.2	NP_001123616.1	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding protein 3	157	Gly-rich.					extracellular region	calcium ion binding|growth factor binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|prostate(2)|upper_aerodigestive_tract(3)	23						TCCTGCTCAGGCCGGGGCCTG	0.721000													4	14					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91707125	91707125	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:91707125T>C	ENST00000359028.2	+	31	7142	c.6917T>C	c.(6916-6918)aTt>aCt	p.I2306T	AKAP9_ENST00000356239.3_Missense_Mutation_p.I2294T|AKAP9_ENST00000358100.2_Missense_Mutation_p.I2306T			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	2306	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GAGGTAGAAATTGACCAATTA	0.328000			T	BRAF	papillary thyroid								11	46					0	0	1	0	0
GPR182	11318	broad.mit.edu	37	12	57389466	57389466	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:57389466C>T	ENST00000300098.1	+	2	692	c.473C>T	c.(472-474)gCc>gTc	p.A158V		NM_007264.3	NP_009195.1	O15218	GP182_HUMAN	G protein-coupled receptor 182	158						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	15						CTCACCAGCGCCTCCCCCTCC	0.602000													20	36					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141578865	141578865	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:141578865G>A	ENST00000442267.2	-	12	2097	c.2023C>T	c.(2023-2025)Ctg>Ttg	p.L675L		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	675	Rab-GAP TBC.					intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				AACCAAGACAGGGAGATGGTG	0.478000													50	40					0	0	1	0	0
SYT13	57586	broad.mit.edu	37	11	45265864	45265864	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:45265864C>T	ENST00000020926.3	-	6	1131	c.1020G>A	c.(1018-1020)ctG>ctA	p.L340L		NM_001247987.1|NM_020826.2	NP_001234916.1|NP_065877.1	Q7L8C5	SYT13_HUMAN	synaptotagmin XIII	340	C2 2.					transport vesicle				breast(1)|large_intestine(3)|lung(16)|ovary(1)|skin(2)	23						GCTTCTTCTTCAGCTTCCGAG	0.532000													18	12					0	0	1	0	0
EDNRB	1910	broad.mit.edu	37	13	78477464	78477464	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:78477464T>C	ENST00000377211.4	-	4	1050	c.898A>G	c.(898-900)Aaa>Gaa	p.K300E	EDNRB_ENST00000446573.1_Missense_Mutation_p.K210E|EDNRB_ENST00000334286.5_Missense_Mutation_p.K210E	NM_001201397.1	NP_001188326.1	P24530	EDNRB_HUMAN	endothelin receptor type B	210					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(18)|lung(16)|skin(3)	42		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	CCAATTCCTTTAATTCTACTC	0.358000													25	68					0	0	1	0	0
CLMN	79789	broad.mit.edu	37	14	95679660	95679660	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:95679660G>A	ENST00000298912.4	-	6	617	c.504C>T	c.(502-504)tcC>tcT	p.S168S		NM_024734.3	NP_079010.2	Q96JQ2	CLMN_HUMAN	calmin (calponin-like, transmembrane)	168	Actin-binding.					integral to membrane	actin binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(17)|prostate(3)|skin(3)	44				Epithelial(152;0.193)		TGGGTGGGAAGGATGAGTCTG	0.552000													36	23					0	0	1	0	0
THEG	51298	broad.mit.edu	37	19	362368	362368	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:362368C>T	ENST00000342640.4	-	8	1014	c.972G>A	c.(970-972)ctG>ctA	p.L324L	THEG_ENST00000346878.2_Silent_p.L300L	NM_016585.4	NP_057669.1	Q9P2T0	THEG_HUMAN	theg spermatid protein	324					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)|soft_tissue(1)	29		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGTGACATCCAGCACCTCCC	0.617000													50	53					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189456537	189456537	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:189456537G>A	ENST00000264731.3	+	3	387	c.298G>A	c.(298-300)Gac>Aac	p.D100N	TP63_ENST00000382063.4_Missense_Mutation_p.D100N|TP63_ENST00000418709.2_Missense_Mutation_p.D100N|TP63_ENST00000440651.2_Missense_Mutation_p.D100N|TP63_ENST00000320472.5_Missense_Mutation_p.D100N|TP63_ENST00000392460.3_Missense_Mutation_p.D100N	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	100	Transcription activation.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CCGCATGCAGGACTCGGACCT	0.473000										HNSCC(45;0.13)			6	23					0	0	1	0	0
OR56A3	390083	broad.mit.edu	37	11	5969156	5969156	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:5969156G>A	ENST00000329564.6	+	1	587	c.580G>A	c.(580-582)Gat>Aat	p.D194N		NM_001003443.2	NP_001003443.2	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A, member 3	194					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(27)|stomach(1)|upper_aerodigestive_tract(1)	41		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACTCTCCTGCGATGATGTCAC	0.473000													32	31					0	0	1	0	0
SLC4A2	6522	broad.mit.edu	37	7	150761399	150761399	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:150761399C>T	ENST00000485713.1	+	3	1202	c.162C>T	c.(160-162)gcC>gcT	p.A54A	SLC4A2_ENST00000413384.2_Silent_p.A54A|SLC4A2_ENST00000461735.1_Silent_p.A40A|SLC4A2_ENST00000310317.5_Intron|SLC4A2_ENST00000392826.2_Silent_p.A45A	NM_001199692.1	NP_001186621.1	P04920	B3A2_HUMAN	solute carrier family 4 (anion exchanger), member 2	54	Pro-rich.				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(14)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	33			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TACAGGAGGCCGGGTCTCGTG	0.662000													14	17					0	0	1	0	0
HORMAD2	150280	broad.mit.edu	37	22	30494841	30494841	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:30494841G>A	ENST00000336726.6	+	3	407	c.51_splice	c.e3-1	p.E18_splice	HORMAD2_ENST00000403975.1_Splice_Site_p.E18_splice	NM_152510.2	NP_689723.1	Q8N7B1	HORM2_HUMAN	HORMA domain containing 2	18					meiosis|mitosis	chromosome|nucleus				large_intestine(1)|lung(1)	2			Epithelial(10;0.125)			GTTTTTCCAGGAAACAGTTTT	0.338000													13	38					0	0	1	0	0
GYPA	2993	broad.mit.edu	37	4	145038071	145038071	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:145038071C>T	ENST00000360771.4	-	5	408	c.293G>A	c.(292-294)gGg>gAg	p.G98E	GYPA_ENST00000504786.1_Missense_Mutation_p.G66E|GYPA_ENST00000324022.10_Missense_Mutation_p.G65E|GYPA_ENST00000512064.1_Missense_Mutation_p.G85E|RP11-673E1.4_ENST00000506982.1_RNA|GYPB_ENST00000283126.7_Intron|GYPA_ENST00000512789.1_Missense_Mutation_p.G33E|GYPA_ENST00000503627.1_Missense_Mutation_p.G53E|GYPA_ENST00000535709.1_Missense_Mutation_p.G72E	NM_002099.6	NP_002090.4	P02724	GLPA_HUMAN	glycophorin A (MNS blood group)	98					interspecies interaction between organisms	membrane fraction	receptor activity			central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	10	all_hematologic(180;0.15)					AGCCATCACCCCAAAAATAAT	0.343000													24	36					0	0	1	0	0
KLF12	11278	broad.mit.edu	37	13	74269665	74269665	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:74269665G>A	ENST00000377669.2	-	7	1197	c.1171C>T	c.(1171-1173)Cat>Tat	p.H391Y	KLF12_ENST00000377666.4_Missense_Mutation_p.H391Y	NM_007249.4	NP_009180.3	Q9Y4X4	KLF12_HUMAN	Kruppel-like factor 12	391					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	16		Prostate(6;0.00217)|Breast(118;0.0838)		GBM - Glioblastoma multiforme(99;0.00677)		AGGGCCAAATGATCTGACCGG	0.547000													21	30					0	0	1	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227222395	227222395	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:227222395G>A	ENST00000366769.3	-	25	4623	c.3332C>T	c.(3331-3333)tCt>tTt	p.S1111F	CDC42BPA_ENST00000366767.3_Missense_Mutation_p.S1030F|CDC42BPA_ENST00000366765.3_Missense_Mutation_p.S1124F|CDC42BPA_ENST00000334218.5_Missense_Mutation_p.S1111F|CDC42BPA_ENST00000366766.2_Missense_Mutation_p.S1146F|CDC42BPA_ENST00000366764.2_Missense_Mutation_p.S1083F|CDC42BPA_ENST00000535525.1_Missense_Mutation_p.S1091F	NM_003607.3	NP_003598.2	Q5VT25	MRCKA_HUMAN	CDC42 binding protein kinase alpha (DMPK-like)	1124	PH.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(12)|lung(32)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|urinary_tract(2)	77		all_cancers(173;0.156)|Prostate(94;0.0792)				ACTGGGCTGAGATGCTTTTCC	0.393000													12	88					0	0	1	0	0
RRP12	23223	broad.mit.edu	37	10	99139478	99139478	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:99139478G>T	ENST00000370992.4	-	14	1694	c.1583C>A	c.(1582-1584)aCg>aAg	p.T528K	RRP12_ENST00000315563.6_Missense_Mutation_p.T428K|RRP12_ENST00000536831.1_Missense_Mutation_p.T246K|RRP12_ENST00000414986.1_Missense_Mutation_p.T467K	NM_015179.3	NP_055994.2	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog (S. cerevisiae)	528						integral to membrane|nuclear membrane|nucleolus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(2)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		AAGAGCCGCCGTGTGGGGGAA	0.592000													40	9					8.16277e-20	8.29704e-20	1	1	0
MYH9	4627	broad.mit.edu	37	22	36689450	36689450	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:36689450G>A	ENST00000216181.5	-	30	4250	c.4020C>T	c.(4018-4020)tcC>tcT	p.S1340S		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	1340					actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						GCTCCCGGAAGGAATTCTTCT	0.637000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				30	58					0	0	1	0	0
SLC2A13	114134	broad.mit.edu	37	12	40345071	40345071	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:40345071A>G	ENST00000280871.4	-	4	1072	c.1022T>C	c.(1021-1023)aTt>aCt	p.I341T	SLC2A13_ENST00000380858.1_Missense_Mutation_p.I341T	NM_052885.3	NP_443117.3	Q96QE2	MYCT_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 13	341						integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	29		Lung NSC(34;0.105)|all_lung(34;0.123)				GATGGTGTTAATGCCTGAGAG	0.383000										HNSCC(50;0.14)			12	13					0	0	1	0	0
OGG1	4968	broad.mit.edu	37	3	9793534	9793534	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:9793534A>T	ENST00000302036.7	+	3	809	c.466A>T	c.(466-468)Act>Tct	p.T156S	OGG1_ENST00000302003.7_Missense_Mutation_p.T156S|OGG1_ENST00000339511.5_Missense_Mutation_p.T156S|OGG1_ENST00000344629.7_Missense_Mutation_p.T156S|OGG1_ENST00000383826.5_Missense_Mutation_p.T156S|OGG1_ENST00000302008.8_Missense_Mutation_p.T156S|OGG1_ENST00000449570.2_Missense_Mutation_p.T156S|OGG1_ENST00000349503.5_Missense_Mutation_p.T156S	NM_016821.2	NP_058214.1	O15527	OGG1_HUMAN	8-oxoguanine DNA glycosylase	156					depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding			kidney(2)|large_intestine(2)|lung(2)|skin(1)|urinary_tract(1)	8	Medulloblastoma(99;0.227)					CGCCCGCATCACTGGCATGGT	0.572000								Base excision repair (BER), DNA glycosylases					66	46					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57372418	57372418	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:57372418G>A	ENST00000361249.3	+	8	1271	c.1175G>A	c.(1174-1176)gGa>gAa	p.G392E		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	392	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						AATGTTGGTGGAGGTTTATCA	0.413000													15	102					0	0	1	0	0
DCAF8L2	347442	broad.mit.edu	37	X	27766203	27766203	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:27766203G>A	ENST00000451261.2	+	5	1590	c.1191G>A	c.(1189-1191)agG>agA	p.R397R		NM_001136533.1	NP_001130005.1			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|endometrium(9)|kidney(3)|lung(7)|pancreas(1)|skin(3)	24						ATGACCAGAGGAAAATTGATA	0.393000													10	5					0	0	1	0	0
ALDH2	217	broad.mit.edu	37	12	112228368	112228368	+	Splice_Site	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:112228368T>C	ENST00000261733.2	+	6	742		c.e6+2		RP11-162P23.2_ENST00000546840.2_Splice_Site|ALDH2_ENST00000416293.3_Splice_Site	NM_000690.3	NP_000681.2	P05091	ALDH2_HUMAN	aldehyde dehydrogenase 2 family (mitochondrial)						carbohydrate metabolic process|ethanol oxidation|neurotransmitter biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	aldehyde dehydrogenase|aldehyde dehydrogenase (NAD) activity|electron carrier activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(6)|ovary(2)|prostate(1)|skin(2)|stomach(1)	22					Disulfiram(DB00822)|Guanidine(DB00536)|NADH(DB00157)|Nitroglycerin(DB00727)	ATCAAGGAGGTGCGTGGCTTA	0.542000			T	HMGA2	leiomyoma								18	15					0	0	1	0	0
DNAJB7	150353	broad.mit.edu	37	22	41257102	41257102	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:41257102C>T	ENST00000307221.4	-	1	1028	c.897G>A	c.(895-897)gaG>gaA	p.E299E	XPNPEP3_ENST00000414396.1_Intron|XPNPEP3_ENST00000482652.1_Intron|XPNPEP3_ENST00000357137.4_Intron|XPNPEP3_ENST00000541156.1_Intron	NM_145174.1	NP_660157.1	Q7Z6W7	DNJB7_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 7	299					protein folding		heat shock protein binding|unfolded protein binding			breast(2)|endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	10						TCTTTTGCACCTCTTTACGCT	0.363000													18	56					0	0	1	0	0
ENPP5	59084	broad.mit.edu	37	6	46135701	46135701	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:46135701C>T	ENST00000371383.2	-	3	559	c.299G>A	c.(298-300)cGg>cAg	p.R100Q	ENPP5_ENST00000230565.3_Missense_Mutation_p.R100Q			Q9UJA9	ENPP5_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)	100						extracellular region|integral to membrane	hydrolase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	12						AGATTTGTTCCGAATAGGATC	0.378000													27	16					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2876008	2876008	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:2876008G>A	ENST00000602557.1	-	53	8578	c.8023C>T	c.(8023-8025)Cga>Tga	p.R2675*	CSMD1_ENST00000400186.3_Intron|CSMD1_ENST00000542608.1_Intron|CSMD1_ENST00000602723.1_Intron|CSMD1_ENST00000537824.1_Nonsense_Mutation_p.R2674*|CSMD1_ENST00000520002.1_Nonsense_Mutation_p.R2675*			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2675	Sushi 17.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCCAGACATCGAGTTTCGCTG	0.458000													93	118					0	0	1	0	0
CATSPER1	117144	broad.mit.edu	37	11	65793107	65793107	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:65793107G>A	ENST00000312106.5	-	1	881	c.744C>T	c.(742-744)tcC>tcT	p.S248S		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	248	His-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						AGGAATGAGGGGAAATGGTCT	0.577000													6	15					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121767706	121767706	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:121767706G>A	ENST00000261367.7	+	8	2794	c.1366G>A	c.(1366-1368)Gaa>Aaa	p.E456K	SNCAIP_ENST00000542191.1_5'UTR|SNCAIP_ENST00000504884.2_3'UTR|SNCAIP_ENST00000379533.2_Missense_Mutation_p.E456K|SNCAIP_ENST00000261368.8_Missense_Mutation_p.E409K|SNCAIP_ENST00000379536.2_Missense_Mutation_p.E349K|SNCAIP_ENST00000379538.3_Missense_Mutation_p.E43K|SNCAIP_ENST00000503116.2_Missense_Mutation_p.E456K|SNCAIP_ENST00000414317.2_Intron			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	409					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		GAGCGAAACAGAAGCCATTGC	0.408000													8	3					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57327492	57327492	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:57327492G>A	ENST00000326441.9	-	10	2681	c.2318C>T	c.(2317-2319)tCa>tTa	p.S773L	PEG3_ENST00000593695.1_Missense_Mutation_p.S647L|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.S773L|ZIM2_ENST00000221722.5_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.S649L|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000599935.1_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	773					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CCTCTCATATGATTTTGCCTC	0.438000													46	112					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11098748	11098748	+	RNA	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr21:11098748C>T	ENST00000470054.1	-	0	177									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		cttactgctccagccccactc	0.622000													10	186					0	0	1	0	0
CYTIP	9595	broad.mit.edu	37	2	158275099	158275099	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:158275099T>A	ENST00000264192.3	-	7	670	c.549A>T	c.(547-549)caA>caT	p.Q183H	CYTIP_ENST00000540637.1_Missense_Mutation_p.Q77H	NM_004288.4	NP_004279.3	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	183	Interaction with CYTH1.				regulation of cell adhesion	cell cortex|early endosome	protein binding			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	15						GTTTCAAAGTTTGCTGTGAGa	0.328000													19	63					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7340418	7340418	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:7340418G>A	ENST00000486284.1	+	3	1058	c.784G>A	c.(784-786)Gac>Aac	p.D262N	GRM7_ENST00000402647.2_Missense_Mutation_p.D262N|GRM7_ENST00000403881.1_Missense_Mutation_p.D262N|GRM7_ENST00000389336.4_Missense_Mutation_p.D262N|GRM7_ENST00000357716.4_Missense_Mutation_p.D262N	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	262					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	GGAACGCAAAGACAGGACCAT	0.448000													19	19					0	0	1	0	0
AHSA1	10598	broad.mit.edu	37	14	77928548	77928548	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:77928548C>T	ENST00000216479.3	+	3	477	c.317C>T	c.(316-318)cCc>cTc	p.P106L	AHSA1_ENST00000555457.1_3'UTR|AHSA1_ENST00000535854.2_Missense_Mutation_p.P106L	NM_012111.2	NP_036243.1	O95433	AHSA1_HUMAN	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)	106					protein folding|response to stress	cytosol|endoplasmic reticulum	ATPase activator activity|chaperone binding			endometrium(1)|kidney(3)|large_intestine(1)|prostate(1)|skin(1)|stomach(1)	8			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)		GTGGAGATCCCCAATTTGTCT	0.428000													23	20					0	0	1	0	0
PEAR1	375033	broad.mit.edu	37	1	156879667	156879667	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:156879667C>T	ENST00000338302.3	+	13	1761	c.1536C>T	c.(1534-1536)acC>acT	p.T512T	PEAR1_ENST00000292357.7_Silent_p.T512T			Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	512	EGF-like 6.					integral to membrane				breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(6)|lung(22)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)	43	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GTACCTGCACCCCTGGGTGGC	0.677000													13	88					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56403075	56403075	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:56403075C>T	ENST00000355701.3	-	4	1441		c.e4-1		BZRAP1_ENST00000343736.4_Splice_Site|BZRAP1_ENST00000268893.6_Intron|BZRAP1-AS1_ENST00000579527.1_RNA	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1							mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGGCACTCACCTAGCCAGAGG	0.637000													17	17					0	0	1	0	0
RANBP3L	202151	broad.mit.edu	37	5	36269561	36269561	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:36269561C>T	ENST00000296604.3	-	4	684	c.199G>A	c.(199-201)Ggt>Agt	p.G67S	RANBP3L_ENST00000515759.1_Missense_Mutation_p.G67S|RANBP3L_ENST00000502994.1_Missense_Mutation_p.G67S	NM_145000.3	NP_659437.3	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like	67					intracellular transport					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	16	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			GTTGGAAAACCATTACATTCT	0.353000													31	10					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241697798	241697798	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:241697798G>A	ENST00000498729.2	-	26	2807	c.2561C>T	c.(2560-2562)cCc>cTc	p.P854L	KIF1A_ENST00000320389.7_Missense_Mutation_p.P845L	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	845					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CCGGAACCAGGGGAAGCGGTC	0.637000													25	9					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19698203	19698203	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:19698203C>T	ENST00000328041.6	+	16	1948	c.1751C>T	c.(1750-1752)tCc>tTc	p.S584F		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	584						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						CTGATCTACTCCGTAGGCTTG	0.502000													283	181					0	0	1	0	0
PAF1	54623	broad.mit.edu	37	19	39880154	39880154	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:39880154C>T	ENST00000221265.3	-	5	655	c.325G>A	c.(325-327)Gaa>Aaa	p.E109K	PAF1_ENST00000221266.7_Missense_Mutation_p.E99K|PAF1_ENST00000595564.1_Missense_Mutation_p.E99K	NM_019088.3	NP_061961.2	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	109					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|urinary_tract(2)	17	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			ATCTCCTCTTCCAAAAGTTTC	0.587000													15	36					0	0	1	0	0
PC	5091	broad.mit.edu	37	11	66620223	66620223	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:66620223G>A	ENST00000393960.1	-	14	1879	c.1598C>T	c.(1597-1599)cCc>cTc	p.P533L	PC_ENST00000393955.2_Missense_Mutation_p.P533L|PC_ENST00000393958.2_Missense_Mutation_p.P533L	NM_001040716.1	NP_001035806.1	P11498	PYC_HUMAN	pyruvate carboxylase	533					gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	CCTACCTATGGGCACTGCAGG	0.632000													24	22					0	0	1	0	0
ANKFN1	162282	broad.mit.edu	37	17	54558059	54558059	+	Silent	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:54558059T>C	ENST00000566473.2	+	16	1980	c.1980T>C	c.(1978-1980)tcT>tcC	p.S660S	ANKFN1_ENST00000318698.2_Silent_p.S660S			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	660										NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						AAAAGCTTTCTGGCTCTGAAT	0.408000													4	97					0	0	1	0	0
OR52A5	390054	broad.mit.edu	37	11	5153366	5153366	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:5153366C>T	ENST00000307388.1	-	1	506	c.507G>A	c.(505-507)ctG>ctA	p.L169L		NM_001005160.2	NP_001005160.1	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A, member 5	169					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(18)|skin(3)	35		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		GATAGTGTTTCAGACAGCATT	0.453000													11	45					0	0	1	0	0
OR6X1	390260	broad.mit.edu	37	11	123624923	123624923	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:123624923G>A	ENST00000327930.2	-	1	330	c.304C>T	c.(304-306)Cac>Tac	p.H102Y		NM_001005188.1	NP_001005188.1	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X, member 1	102					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)	23		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		ACGAAGAAGTGGAAGAAGGCC	0.517000													5	16					0	0	1	0	0
MET	4233	broad.mit.edu	37	7	116435842	116435842	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:116435842C>T	ENST00000397752.3	+	20	4132	c.3932C>T	c.(3931-3933)cCc>cTc	p.P1311L	MET_ENST00000539704.1_Missense_Mutation_p.P181L|MET_ENST00000318493.6_Missense_Mutation_p.P1329L	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	1311	Interaction with RANBP9.|Protein kinase.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TGCCCAGACCCCTTGTAAGTA	0.428000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)		OREG0003446	type=REGULATORY REGION|Gene=MET|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	69	68					0	0	1	0	0
LIX1L	128077	broad.mit.edu	37	1	145492376	145492376	+	Splice_Site	SNP	G	G	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:145492376G>T	ENST00000369308.3	+	3	671		c.e3+1		RP11-315I20.1_ENST00000595518.1_RNA|RP11-315I20.1_ENST00000597144.1_RNA|RP11-315I20.1_ENST00000598103.1_RNA|RP11-315I20.1_ENST00000598354.1_RNA|RP11-315I20.1_ENST00000600340.1_RNA|RP11-315I20.1_ENST00000437207.1_RNA|RP11-315I20.1_ENST00000599469.1_RNA	NM_153713.1	NP_714924.1	Q8IVB5	LIX1L_HUMAN	Lix1 homolog (mouse)-like											large_intestine(4)|lung(6)|ovary(2)|skin(1)	13	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ATCTTTTAATGTAAGTTGTAT	0.433000													16	65					1.45105e-14	1.47325e-14	1	1	0
TMC2	117532	broad.mit.edu	37	20	2560642	2560642	+	Nonsense_Mutation	SNP	G	G	A	rs143423360		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:2560642G>A	ENST00000358864.1	+	7	789	c.774G>A	c.(772-774)tgG>tgA	p.W258*		NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	258						integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						TTCTCCGATGGATGTATGGAG	0.403000													58	33					0	0	1	0	0
DACT1	51339	broad.mit.edu	37	14	59113512	59113512	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:59113512C>T	ENST00000395153.3	+	4	2207	c.2060C>T	c.(2059-2061)tCc>tTc	p.S687F	DACT1_ENST00000556859.1_Missense_Mutation_p.S443F|DACT1_ENST00000395151.3_Missense_Mutation_p.S443F|DACT1_ENST00000335867.4_Missense_Mutation_p.S724F|DACT1_ENST00000541264.2_Missense_Mutation_p.S443F	NM_001079520.1|NM_016651.5	NP_001072988.1|NP_057735.2	Q9NYF0	DACT1_HUMAN	dishevelled-binding antagonist of beta-catenin 1	724					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(7)|kidney(3)|large_intestine(11)|lung(27)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	53						GCTAGCGACTCCGAGTACTCG	0.667000													17	79					0	0	1	0	0
SAC3D1	29901	broad.mit.edu	37	11	64812008	64812008	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:64812008G>A	ENST00000398846.1	+	2	1275	c.886G>A	c.(886-888)Gcc>Acc	p.A296T	SAC3D1_ENST00000530213.1_3'UTR|SAC3D1_ENST00000531072.1_Missense_Mutation_p.A296T	NM_013299.3	NP_037431.3			SAC3 domain containing 1											endometrium(2)|lung(1)	3						CCTGTGCCAGGCCCACGGGCT	0.622000													25	22					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19544045	19544045	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:19544045C>T	ENST00000507958.1	-	11	2313	c.1323G>A	c.(1321-1323)agG>agA	p.R441R	CDH18_ENST00000382275.1_Silent_p.R441R|CDH18_ENST00000511273.1_Silent_p.R441R|CDH18_ENST00000502796.1_Silent_p.R441R|CDH18_ENST00000506372.1_Silent_p.R441R|CDH18_ENST00000274170.4_Silent_p.R441R			Q13634	CAD18_HUMAN	cadherin 18, type 2	441	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CCTTTGTAGTCCTAATGGTCC	0.353000													33	8					0	0	1	0	0
IFI44	10561	broad.mit.edu	37	1	79120881	79120881	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:79120881G>A	ENST00000370747.4	+	4	762	c.677G>A	c.(676-678)gGg>gAg	p.G226E	IFI44_ENST00000495254.1_3'UTR|IFI44_ENST00000545124.1_5'UTR	NM_006417.4	NP_006408.3	Q8TCB0	IFI44_HUMAN	interferon-induced protein 44	226					response to virus	cytoplasm				central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	21						AATACAACTGGGATATCTGAG	0.428000													12	74					0	0	1	0	0
ZNF236	7776	broad.mit.edu	37	18	74592081	74592081	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr18:74592081C>T	ENST00000253159.8	+	8	1189	c.991C>T	c.(991-993)Cag>Tag	p.Q331*	ZNF236_ENST00000320610.9_Nonsense_Mutation_p.Q333*	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	331					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		CACACTTTTTCAGACGTTACC	0.448000													31	48					0	0	1	0	0
BCL9L	283149	broad.mit.edu	37	11	118779354	118779354	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:118779354G>A	ENST00000334801.3	-	2	1001	c.37C>T	c.(37-39)Ccc>Tcc	p.P13S	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	13					negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		CTCCTCCTGGGGTGGGGTAAC	0.582000													13	26					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9064917	9064917	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:9064917G>A	ENST00000397910.4	-	3	22732	c.22529C>T	c.(22528-22530)aCc>aTc	p.T7510I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7512	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AATGGAGATGGTACCCATTGC	0.473000													23	39					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139151314	139151314	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:139151314C>T	ENST00000395297.1	-	18	3986	c.3816G>A	c.(3814-3816)aaG>aaA	p.K1272K		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1272										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ACCCGGATTTCTTCAGTTTCT	0.398000										HNSCC(54;0.14)			15	54					0	0	1	0	0
TPSG1	25823	broad.mit.edu	37	16	1272654	1272654	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:1272654C>T	ENST00000234798.4	-	4	513	c.509G>A	c.(508-510)gGa>gAa	p.G170E		NM_012467.3	NP_036599.3	Q9NRR2	TRYG1_HUMAN	tryptase gamma 1	170	Peptidase S1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			liver(1)|lung(2)|skin(1)	4		Hepatocellular(780;0.00369)				CTCCTCACCTCCCTCCCGCGT	0.667000													78	101					0	0	1	0	0
BCR	613	broad.mit.edu	37	22	23656240	23656240	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:23656240C>T	ENST00000305877.8	+	21	4294	c.3543C>T	c.(3541-3543)ttC>ttT	p.F1181F	BCR_ENST00000359540.3_Silent_p.F1137F|BCR_ENST00000436990.2_3'UTR	NM_004327.3	NP_004318.3	P11274	BCR_HUMAN	breakpoint cluster region	1181	Rho-GAP.				regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	35						CCTTCCTTTTCCTTCTGGACC	0.627000			T	"""ABL1,  FGFR1, JAK2 """	"""CML, ALL, AML"""								64	57					0	0	1	0	0
ARMC5	79798	broad.mit.edu	37	16	31477864	31477864	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:31477864C>T	ENST00000408912.3	+	8	3064	c.2747C>T	c.(2746-2748)cCc>cTc	p.P916L	ARMC5_ENST00000412665.2_Missense_Mutation_p.P465L|ARMC5_ENST00000268314.4_Missense_Mutation_p.P821L|ARMC5_ENST00000563544.1_Missense_Mutation_p.P821L|ARMC5_ENST00000538189.1_Missense_Mutation_p.P853L|ARMC5_ENST00000457010.2_3'UTR			Q96C12	ARMC5_HUMAN	armadillo repeat containing 5	821							binding			central_nervous_system(1)|endometrium(4)|large_intestine(3)|liver(2)|lung(12)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						GGGCCCGTGCCCCCACCAGGC	0.692000													14	23					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995832	140995832	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:140995832C>T	ENST00000285879.4	+	4	2928	c.2642C>T	c.(2641-2643)tCc>tTc	p.S881F	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	881							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TATACAAGTTCCTCAGACACC	0.493000										HNSCC(15;0.026)			101	9					0	0	1	0	0
NCKAP1	10787	broad.mit.edu	37	2	183860544	183860544	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:183860544G>A	ENST00000360982.2	-	8	1402	c.644C>T	c.(643-645)tCt>tTt	p.S215F	NCKAP1_ENST00000361354.3_Missense_Mutation_p.S209F	NM_205842.1	NP_995314.1	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1	209					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			breast(3)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(11)|lung(16)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			CATTTGAAGAGAAATTAGTGC	0.358000													24	10					0	0	1	0	0
RGS7	6000	broad.mit.edu	37	1	241262022	241262022	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:241262022C>T	ENST00000366565.1	-	3	500	c.119G>A	c.(118-120)gGa>gAa	p.G40E	RGS7_ENST00000446183.2_5'UTR|RGS7_ENST00000407727.1_Missense_Mutation_p.G40E|RGS7_ENST00000366563.1_Missense_Mutation_p.G40E|RGS7_ENST00000401882.1_Missense_Mutation_p.G40E|RGS7_ENST00000348120.2_Missense_Mutation_p.G40E|RGS7_ENST00000331110.7_Missense_Mutation_p.G14E|RGS7_ENST00000366564.1_Missense_Mutation_p.G40E|RGS7_ENST00000366562.4_Missense_Mutation_p.G40E	NM_002924.4	NP_002915.3	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	40	DEP.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(51)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			AATAGGAATTCCATTTTTTTC	0.348000													10	62					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	114111003	114111003	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:114111003G>A	ENST00000297405.5	-	5	1143	c.899C>T	c.(898-900)tCt>tTt	p.S300F	CSMD3_ENST00000352409.3_Missense_Mutation_p.S300F|CSMD3_ENST00000519485.1_5'UTR|CSMD3_ENST00000343508.3_Missense_Mutation_p.S260F|CSMD3_ENST00000455883.2_Missense_Mutation_p.S300F	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	300	CUB 2.					integral to membrane|plasma membrane		p.S300F(1)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AGGTGGCTCAGAACCTTCTAT	0.363000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			9	16					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40433514	40433514	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:40433514T>A	ENST00000221347.6	-	2	762	c.755A>T	c.(754-756)tAt>tTt	p.Y252F		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	252	IgGFc-binding.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGGTACTACATAGTGGGTGCC	0.592000													21	34					0	0	1	0	0
ATP11A	23250	broad.mit.edu	37	13	113536357	113536357	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:113536357C>T	ENST00000375630.2	+	29	3643	c.3555C>T	c.(3553-3555)tcC>tcT	p.S1185S	ATP11A_ENST00000487903.1_3'UTR|ATP11A_ENST00000375645.3_3'UTR	NM_032189.3	NP_115565.3	P98196	AT11A_HUMAN	ATPase, class VI, type 11A	0					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(12)|lung(17)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	51	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				GCCCTAGGTCCCGTGTGGGAA	0.637000													17	98					0	0	1	0	0
IGFN1	91156	broad.mit.edu	37	1	201185595	201185595	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:201185595C>T	ENST00000335211.4	+	16	9439	c.9309C>T	c.(9307-9309)ccC>ccT	p.P3103P	IGFN1_ENST00000295591.8_Silent_p.P263P	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						AGCCTGATCCCCCACAAGGCC	0.677000													26	10					0	0	1	0	0
LPIN3	64900	broad.mit.edu	37	20	39983347	39983347	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:39983347C>T	ENST00000373257.3	+	12	1681	c.1590C>T	c.(1588-1590)tcC>tcT	p.S530S		NM_022896.1	NP_075047.1	Q9BQK8	LPIN3_HUMAN	lipin 3	530					fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(7)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Myeloproliferative disorder(115;0.000739)				GGTGGTTTTCCTGGCGACGCA	0.627000													79	38					0	0	1	0	0
SLC22A17	51310	broad.mit.edu	37	14	23817500	23817500	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:23817500G>A	ENST00000354772.3	-	6	1211	c.708C>T	c.(706-708)ttC>ttT	p.F236F	SLC22A17_ENST00000206544.8_Silent_p.F236F|SLC22A17_ENST00000397260.3_Silent_p.F125F|SLC22A17_ENST00000474057.1_5'UTR|SLC22A17_ENST00000397267.1_Silent_p.F236F	NM_016609.3	NP_057693.3	Q8WUG5	S22AH_HUMAN	solute carrier family 22, member 17	236					siderophore transport	integral to organelle membrane|integral to plasma membrane|vacuolar membrane	transmembrane receptor activity|transmembrane transporter activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	15	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00643)		CGGACTCCAGGAACAAACCAG	0.617000													53	58					0	0	1	0	0
POLDIP3	84271	broad.mit.edu	37	22	42998027	42998027	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:42998027G>A	ENST00000252115.5	-	3	590	c.486C>T	c.(484-486)ccC>ccT	p.P162P	POLDIP3_ENST00000339677.6_Intron|POLDIP3_ENST00000491021.1_5'UTR|POLDIP3_ENST00000451060.2_Silent_p.P6P|POLDIP3_ENST00000348657.2_Intron	NM_032311.3	NP_115687.2	Q9BY77	PDIP3_HUMAN	polymerase (DNA-directed), delta interacting protein 3	162					positive regulation of translation	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|upper_aerodigestive_tract(1)	16						CGGCAGGATGGGGATGAAGTG	0.507000													35	65					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179641543	179641543	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:179641543C>T	ENST00000589042.1	-	28	5272	c.5048G>A	c.(5047-5049)cGa>cAa	p.R1683Q	TTN_ENST00000460472.2_Missense_Mutation_p.R1637Q|TTN_ENST00000342175.6_Missense_Mutation_p.R1637Q|TTN_ENST00000360870.5_Missense_Mutation_p.R1683Q|TTN_ENST00000359218.5_Missense_Mutation_p.R1637Q|TTN_ENST00000591111.1_Missense_Mutation_p.R1683Q|TTN_ENST00000342992.6_Missense_Mutation_p.R1683Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1438							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGGCCATATCGCAAATGGAG	0.458000													11	45					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152639303	152639303	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:152639303C>T	ENST00000367255.5	-	86	17086	c.16485G>A	c.(16483-16485)aaG>aaA	p.K5495K	SYNE1_ENST00000356820.4_Silent_p.K19K|SYNE1_ENST00000448038.1_Silent_p.K5424K|SYNE1_ENST00000423061.1_Silent_p.K5424K|SYNE1_ENST00000265368.4_Silent_p.K5495K|SYNE1_ENST00000341594.5_Intron	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5495					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGGCCAGTGGCTTACCCAGTT	0.453000										HNSCC(10;0.0054)			25	37					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955513	18955513	+	Silent	SNP	G	G	A	rs137866403	byFrequency	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:18955513G>A	ENST00000302797.3	-	1	1043	c.819C>T	c.(817-819)ttC>ttT	p.F273F		NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	273					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						AGCCCACGAAGAAGTAAATGA	0.502000													24	82					0	0	1	0	0
RHBDD3	25807	broad.mit.edu	37	22	29656197	29656197	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:29656197G>A	ENST00000216085.7	-	7	1437	c.1013C>T	c.(1012-1014)cCt>cTt	p.P338L		NM_012265.1	NP_036397.1	Q9Y3P4	RHBD3_HUMAN	rhomboid domain containing 3	338	UBA.					integral to membrane	serine-type endopeptidase activity			lung(1)|ovary(1)	2						CTGCTCCGTAGGGAAGCCCAT	0.677000													4	7					0	0	1	0	0
SIM1	6492	broad.mit.edu	37	6	100841743	100841743	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:100841743C>T	ENST00000369208.3	-	11	1972	c.1190G>A	c.(1189-1191)aGa>aAa	p.R397K	SIM1_ENST00000262901.4_Missense_Mutation_p.R397K			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	397	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		AGATTCCGATCTTTCTGTGTG	0.502000													8	28					0	0	1	0	0
VANGL1	81839	broad.mit.edu	37	1	116206695	116206695	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:116206695C>T	ENST00000355485.2	+	4	889	c.618C>T	c.(616-618)gtC>gtT	p.V206V	VANGL1_ENST00000369510.3_Silent_p.V204V|VANGL1_ENST00000369509.1_Silent_p.V206V|VANGL1_ENST00000310260.3_Silent_p.V206V	NM_001172411.1|NM_138959.2	NP_001165882.1|NP_620409.1	Q8TAA9	VANG1_HUMAN	VANGL planar cell polarity protein 1	206					multicellular organismal development	integral to membrane	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|liver(2)|lung(13)|urinary_tract(1)	27	Lung SC(450;0.211)	all_cancers(81;1.24e-06)|all_epithelial(167;1.02e-06)|all_lung(203;7.95e-06)|Lung NSC(69;4.97e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TTTACGGGGTCCGCATTTTGG	0.517000													27	166					0	0	1	0	0
TCP10L	140290	broad.mit.edu	37	21	33956515	33956515	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr21:33956515C>T	ENST00000300258.3	-	2	213	c.100G>A	c.(100-102)Gca>Aca	p.A34T		NM_144659.5	NP_653260.1			t-complex 10-like											breast(1)|central_nervous_system(1)|liver(1)|skin(1)	4						ACCTCGGCTGCCACAGCTGTC	0.627000													32	68					0	0	1	0	0
PPIL2	23759	broad.mit.edu	37	22	22040809	22040809	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:22040809C>T	ENST00000406385.1	+	11	812	c.752C>T	c.(751-753)aCc>aTc	p.T251I	PPIL2_ENST00000335025.7_Missense_Mutation_p.T251I|PPIL2_ENST00000456792.2_Missense_Mutation_p.T230I|PPIL2_ENST00000492445.2_Missense_Mutation_p.T251I|PPIL2_ENST00000398831.3_Missense_Mutation_p.T251I|PPIL2_ENST00000412327.1_Missense_Mutation_p.T251I			Q13356	PPIL2_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 2	251					blood coagulation|leukocyte migration|protein folding|protein polyubiquitination	Golgi lumen|nucleus|ubiquitin ligase complex	peptidyl-prolyl cis-trans isomerase activity|ubiquitin-ubiquitin ligase activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	17	Colorectal(54;0.105)					GCTTCCTTCACCTCCACCGCG	0.617000													48	54					0	0	1	0	0
AK5	26289	broad.mit.edu	37	1	77759609	77759609	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:77759609C>T	ENST00000344720.5	+	3	1327	c.301C>T	c.(301-303)Cct>Tct	p.P101S	AK5_ENST00000317704.4_3'UTR|AK5_ENST00000354567.2_Missense_Mutation_p.P127S	NM_012093.3	NP_036225.2	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5	127					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|prostate(1)|skin(2)|stomach(1)	40						GGTTTTTGATCCTACCAGACC	0.413000													46	16					0	0	1	0	0
LARP4	113251	broad.mit.edu	37	12	50854977	50854977	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:50854977C>T	ENST00000398473.2	+	11	1293	c.1181C>T	c.(1180-1182)tCc>tTc	p.S394F	LARP4_ENST00000429001.3_Missense_Mutation_p.S400F|LARP4_ENST00000518561.1_Missense_Mutation_p.S324F|LARP4_ENST00000522085.1_Missense_Mutation_p.S394F|LARP4_ENST00000293618.8_Intron|LARP4_ENST00000518444.1_Missense_Mutation_p.S393F|LARP4_ENST00000347328.5_Missense_Mutation_p.S323F	NM_052879.4|NM_199188.2	NP_443111.4|NP_954658.2	Q71RC2	LARP4_HUMAN	La ribonucleoprotein domain family, member 4	394							nucleotide binding|RNA binding			breast(3)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(1)|skin(2)|urinary_tract(1)	23						GGCTCTGTATCCTTGGGGGAT	0.438000													28	72					0	0	1	0	0
ZNF700	90592	broad.mit.edu	37	19	12060846	12060846	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:12060846G>A	ENST00000482090.1	+	3	2371	c.1953G>A	c.(1951-1953)aaG>aaA	p.K651K	ZNF763_ENST00000538752.1_Intron|ZNF763_ENST00000591944.1_Intron|ZNF763_ENST00000590798.1_Intron|ZNF700_ENST00000254321.5_Silent_p.K669K|CTD-2006C1.12_ENST00000586394.1_RNA			Q9H0M5	ZN700_HUMAN	zinc finger protein 700	669					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		ZNF700/MAST1_ENST00000251472(2)	breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|pancreas(1)|prostate(1)|urinary_tract(1)	33						ATGAAAGGAAGCACAGAGGAG	0.393000													19	8					0	0	1	0	0
FUS	2521	broad.mit.edu	37	16	31202348	31202348	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:31202348C>T	ENST00000254108.7	+	14	1563	c.1458C>T	c.(1456-1458)ggC>ggT	p.G486G	FUS_ENST00000380244.3_Silent_p.G485G|FUS_ENST00000568685.1_Silent_p.G487G|FUS_ENST00000474990.1_3'UTR	NM_001170634.1|NM_001170937.1|NM_004960.3	NP_001164105.1|NP_001164408.1|NP_004951.1	P35637	FUS_HUMAN	fused in sarcoma	486	Arg/Gly-rich.				cell death|nuclear mRNA splicing, via spliceosome	nucleoplasm	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		FUS/ERG(167)|FUS/DDIT3(631)|FUS/FEV(2)|FUS/ATF1(4)|FUS/CREB3L1(6)|FUS/CREB3L2(158)	breast(3)|endometrium(5)|kidney(3)|large_intestine(1)|lung(5)|prostate(3)|skin(1)|urinary_tract(1)	22		Renal(780;0.000219)|Breast(268;0.00957)|Hepatocellular(780;0.121)		GBM - Glioblastoma multiforme(240;2.31e-05)|Kidney(780;0.000209)		GCTACCGGGGCCGCGGCGGGG	0.587000			T	"""DDIT3, ERG, FEV, ATF1, CREB3L2, CREB3L1"""	"""liposarcoma, AML, Ewing sarcoma, angiomatoid fibrous histiocytoma, fibromyxoid sarcoma"""								29	45					0	0	1	0	0
OR52E6	390078	broad.mit.edu	37	11	5862813	5862813	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:5862813G>A	ENST00000329322.5	-	1	314	c.315C>T	c.(313-315)ttC>ttT	p.F105F	TRIM5_ENST00000380027.1_Intron|OR52E6_ENST00000379946.2_Silent_p.F109F	NM_001005167.1	NP_001005167.1	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E, member 6	105					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGAAATGGATGAAGAACATCT	0.458000													29	87					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178409975	178409975	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:178409975G>A	ENST00000231188.5	-	9	2550	c.2372C>T	c.(2371-2373)aCc>aTc	p.T791I	GRM6_ENST00000517717.1_Missense_Mutation_p.T791I|RP11-281O15.4_ENST00000519491.1_RNA	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	791					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		GATGCAGGTGGTGTACATGGT	0.587000													23	10					0	0	1	0	0
MMP2	4313	broad.mit.edu	37	16	55518029	55518029	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:55518029G>A	ENST00000219070.4	+	3	991	c.482G>A	c.(481-483)cGa>cAa	p.R161Q	MMP2_ENST00000543485.1_Missense_Mutation_p.R85Q|MMP2_ENST00000437642.2_Missense_Mutation_p.R111Q|MMP2_ENST00000570308.1_Missense_Mutation_p.R85Q	NM_004530.4	NP_004521.1	P08253	MMP2_HUMAN	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	161	Collagenase-like 1.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding	p.R161Q(2)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|liver(2)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	58		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	CGGTTTTCTCGAATCCATGAT	0.547000													18	29					0	0	1	0	0
SUMO3	6612	broad.mit.edu	37	21	46226920	46226920	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr21:46226920G>A	ENST00000397898.3	-	4	390	c.308C>T	c.(307-309)tCc>tTc	p.S103F	SUMO3_ENST00000332859.6_Silent_p.F86F|SUMO3_ENST00000411651.2_Silent_p.F124F|SUMO3_ENST00000479153.1_5'UTR			P55854	SUMO3_HUMAN	small ubiquitin-like modifier 3	0					protein sumoylation	cytoplasm|kinetochore	protein binding			prostate(1)	1				Colorectal(79;0.058)		TCTGCTGCTGGAACACGTCGA	0.602000													18	19					0	0	1	0	0
AGAP1	116987	broad.mit.edu	37	2	236877164	236877164	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:236877164C>T	ENST00000409538.1	+	12	2674	c.2178C>T	c.(2176-2178)ccC>ccT	p.P726P	AGAP1_ENST00000336665.5_Silent_p.P461P|AGAP1_ENST00000428334.2_Silent_p.P353P|AGAP1_ENST00000304032.7_Silent_p.P514P			Q9UPQ3	AGAP1_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	514	Arf-GAP.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						CCACCAGCCCCAAGCTCGACC	0.562000													30	19					0	0	1	0	0
ATXN7L2	127002	broad.mit.edu	37	1	110033817	110033817	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:110033817C>T	ENST00000369870.3	+	10	1647	c.1632C>T	c.(1630-1632)tcC>tcT	p.S544S	ATXN7L2_ENST00000459635.1_3'UTR	NM_153340.4	NP_699171.3	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	544										breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)	17		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		CATCCCCGTCCTTCAGCAAGC	0.652000													15	55					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136562597	136562597	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:136562597C>T	ENST00000264162.2	-	10	4214	c.4204G>A	c.(4204-4206)Gga>Aga	p.G1402R		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1402	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		ATGCTGAGTCCTTTGCCATCT	0.478000													35	24					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235973317	235973317	+	Silent	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:235973317T>C	ENST00000389794.3	-	5	975	c.801A>G	c.(799-801)aaA>aaG	p.K267K	LYST_ENST00000389793.2_Silent_p.K267K|LYST_ENST00000536965.1_Silent_p.K267K			Q99698	LYST_HUMAN	lysosomal trafficking regulator	267					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			ACTTACAAACTTTTTCTAATA	0.388000													38	18					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103206843	103206843	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:103206843C>T	ENST00000428762.1	-	33	4923	c.4764G>A	c.(4762-4764)caG>caA	p.Q1588Q	RELN_ENST00000424685.2_Silent_p.Q1588Q|RELN_ENST00000343529.5_Silent_p.Q1588Q	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	1588					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CCAAAGCCCACTGGGCTGAAT	0.368000													21	21					0	0	1	0	0
SEZ6	124925	broad.mit.edu	37	17	27284389	27284389	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:27284389C>T	ENST00000317338.12	-	12	2899	c.2471G>A	c.(2470-2472)aGt>aAt	p.S824N	SEZ6_ENST00000360295.9_Missense_Mutation_p.S824N|SEZ6_ENST00000335960.6_Intron|PIPOX_ENST00000583215.1_Intron|SEZ6_ENST00000442608.3_Missense_Mutation_p.S824N			Q53EL9	SEZ6_HUMAN	seizure related 6 homolog (mouse)	824	Sushi 4.					integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(4)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	29	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			GGCCCGGTCACTCCACTTGGG	0.562000													104	38					0	0	1	0	0
GHDC	84514	broad.mit.edu	37	17	40343155	40343155	+	Silent	SNP	G	G	A	rs139408288		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:40343155G>A	ENST00000301671.8	-	5	1404	c.963C>T	c.(961-963)atC>atT	p.I321I	GHDC_ENST00000414034.3_Silent_p.I321I|GHDC_ENST00000587427.1_Silent_p.I321I|GHDC_ENST00000436923.2_Silent_p.I321I|GHDC_ENST00000428494.2_Silent_p.I282I|GHDC_ENST00000593209.1_Silent_p.I321I			Q8N2G8	GHDC_HUMAN	GH3 domain containing	321						endoplasmic reticulum|nuclear envelope				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		all_cancers(22;0.000229)|Breast(137;0.00104)|all_epithelial(22;0.00304)		BRCA - Breast invasive adenocarcinoma(366;0.124)		GGAGCAGCTCGATAAAGGGGG	0.632000													38	32					0	0	1	0	0
VPS45	11311	broad.mit.edu	37	1	150117030	150117030	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:150117030C>T	ENST00000369128.5	+	14	1788	c.1548C>T	c.(1546-1548)tcC>tcT	p.S516S	VPS45_ENST00000369130.3_3'UTR|VPS45_ENST00000484306.1_3'UTR			Q9NRW7	VPS45_HUMAN	vacuolar protein sorting 45 homolog (S. cerevisiae)	409					blood coagulation|intracellular protein transport|vesicle docking involved in exocytosis	endosome membrane|Golgi membrane|integral to membrane of membrane fraction				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	21	Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACAGGTTTTCCCTACTAAACA	0.517000													15	3					0	0	1	0	0
LILRB5	10990	broad.mit.edu	37	19	54754973	54754973	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:54754973T>A	ENST00000450632.1	-	13	1739	c.1662A>T	c.(1660-1662)agA>agT	p.R554S	LILRB5_ENST00000316219.5_Intron|LILRB5_ENST00000345866.6_Intron|LILRB5_ENST00000449561.2_Intron			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	561					cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CTCTCCTAGGTCTGGAGTGTT	0.577000													3	20					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110510903	110510903	+	Silent	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:110510903T>C	ENST00000378402.5	+	67	10835	c.10731T>C	c.(10729-10731)tgT>tgC	p.C3577C		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3577					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GTGGGATTTGTTGGCCTACCT	0.398000										HNSCC(38;0.096)			10	21					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30670975	30670975	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:30670975G>A	ENST00000376406.3	-	12	6418	c.5771C>T	c.(5770-5772)tCc>tTc	p.S1924F	MDC1_ENST00000376405.2_Missense_Mutation_p.S1660F|MDC1-AS1_ENST00000442150.1_RNA	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1924	BRCT 1.|Required for nuclear localization (NLS2).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						GACCAGGTGGGAAGCCTCTGC	0.632000								Other conserved DNA damage response genes					16	49					0	0	1	0	0
UGT1A9	54600	broad.mit.edu	37	2	234581115	234581115	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:234581115G>A	ENST00000354728.4	+	1	617	c.535G>A	c.(535-537)Gaa>Aaa	p.E179K	UGT1A10_ENST00000373445.1_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000344644.5_Intron	NM_021027.2	NP_066307.1														breast(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	37		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)		CTATCTTGAAGAAGGTGCACA	0.473000													133	59					0	0	1	0	0
ASL	435	broad.mit.edu	37	7	65557595	65557595	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:65557595G>A	ENST00000304874.9	+	16	1297	c.1195G>A	c.(1195-1197)Gag>Aag	p.E399K	ASL_ENST00000464970.1_3'UTR|ASL_ENST00000395332.3_Missense_Mutation_p.E399K|ASL_ENST00000380839.4_Missense_Mutation_p.E373K|AC068533.7_ENST00000450043.1_Missense_Mutation_p.R167Q|ASL_ENST00000395331.3_Missense_Mutation_p.E379K	NM_000048.3	NP_000039.2	P04424	ARLY_HUMAN	argininosuccinate lyase	399					arginine biosynthetic process via ornithine|arginine catabolic process|urea cycle	cytosol	argininosuccinate lyase activity			breast(3)|endometrium(3)|large_intestine(2)|lung(9)|upper_aerodigestive_tract(1)	18					L-Arginine(DB00125)	GTTCATGGCCGAGACCAAGGG	0.637000													56	47					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25294056	25294056	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:25294056C>T	ENST00000400358.4	+	19	2197	c.2140C>T	c.(2140-2142)Cat>Tat	p.H714Y	SGSM1_ENST00000400359.4_Missense_Mutation_p.H769Y	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	769	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						AGACTCGGGTCATCCTTCCTC	0.582000													26	21					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43905652	43905652	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:43905652C>T	ENST00000562955.1	+	50	6972	c.6972C>T	c.(6970-6972)gcC>gcT	p.A2324A	SZT2_ENST00000372442.1_Silent_p.A1482A	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	2381						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						CTCGCCAGGCCCTGGCCGATG	0.572000													35	56					0	0	1	0	0
DHX32	55760	broad.mit.edu	37	10	127569356	127569356	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:127569356G>A	ENST00000284690.3	-	1	528	c.38C>T	c.(37-39)tCt>tTt	p.S13F	DHX32_ENST00000284688.6_Missense_Mutation_p.S13F	NM_018180.2	NP_060650.2	Q7L7V1	DHX32_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 32	13						mitochondrion|nucleus	ATP binding|helicase activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(2)|stomach(1)	29		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				GCGTTTTTCAGAGGAAGAGTT	0.478000													65	16					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117710693	117710693	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:117710693C>T	ENST00000368508.3	-	12	1777	c.1579G>A	c.(1579-1581)Gaa>Aaa	p.E527K	GOPC_ENST00000467125.1_Intron|ROS1_ENST00000368507.3_Missense_Mutation_p.E536K	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	527					transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		ACGATGAATTCATTAAAAGAC	0.448000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								28	27					0	0	1	0	0
ZSWIM8	23053	broad.mit.edu	37	10	75553423	75553423	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:75553423C>T	ENST00000604729.1	+	11	2688	c.2391C>T	c.(2389-2391)gcC>gcT	p.A797A	ZSWIM8_ENST00000605216.1_Silent_p.A797A|ZSWIM8_ENST00000398706.2_Silent_p.A797A|ZSWIM8_ENST00000604524.1_Silent_p.A797A|ZSWIM8_ENST00000603114.1_Silent_p.A764A|ZSWIM8_ENST00000431225.1_3'UTR					zinc finger, SWIM-type containing 8																		TGGAGCTTGCCCAGGATCTGC	0.622000													50	13					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79326090	79326090	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:79326090G>A	ENST00000428286.1	-	8	1223	c.23C>T	c.(22-24)tCc>tTc	p.S8F	PRUNE2_ENST00000376718.3_Missense_Mutation_p.S367F			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	367					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						TTCTGTTGAGGATGTCCGGCT	0.532000													20	4					0	0	1	0	0
UGT2B17	7367	broad.mit.edu	37	4	69403501	69403501	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:69403501C>T	ENST00000317746.2	-	6	1477	c.1435G>A	c.(1435-1437)Gtc>Atc	p.V479I		NM_001077.3	NP_001068.1	O75795	UDB17_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B17	479					steroid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(14)|ovary(2)|prostate(1)	30						TGGGCTGCGACCCGAAGGTGC	0.483000													29	89					0	0	1	0	0
CHAMP1	283489	broad.mit.edu	37	13	115090371	115090371	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:115090371C>T	ENST00000361283.1	+	3	1363	c.1054C>T	c.(1054-1056)Cct>Tct	p.P352S		NM_001164144.1|NM_001164145.1|NM_032436.2	NP_001157616.1|NP_001157617.1|NP_115812.1	Q96JM3	ZN828_HUMAN	chromosome alignment maintaining phosphoprotein 1	352	Mediates interaction with MAD2L2.|Pro-rich.				attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|protein localization to kinetochore|protein localization to microtubule|sister chromatid biorientation	condensed chromosome kinetochore|cytoplasm|nucleus|spindle	nucleic acid binding|protein binding|zinc ion binding										GAAACCAATTCCTTCTGTATC	0.517000													34	53					0	0	1	0	0
SMIM8	57150	broad.mit.edu	37	6	88049888	88049888	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:88049888A>T	ENST00000392863.1	+	4	279	c.190A>T	c.(190-192)Att>Ttt	p.I64F	SMIM8_ENST00000229570.5_Missense_Mutation_p.I64F	NM_001042493.1	NP_001035958.1			small integral membrane protein 8																		CGTGGCATATATTGGTTATCT	0.353000													6	35					0	0	1	0	0
FAM214A	56204	broad.mit.edu	37	15	52902542	52902542	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr15:52902542G>A	ENST00000261844.7	-	6	721	c.569C>T	c.(568-570)tCa>tTa	p.S190L	FAM214A_ENST00000546305.2_Missense_Mutation_p.S197L	NM_019600.2	NP_062546.2	Q32MH5	K1370_HUMAN	family with sequence similarity 214, member A	190																	TGGAGTCTGTGAAAAATTCCA	0.368000													43	9					0	0	1	0	0
FABP12	646486	broad.mit.edu	37	8	82439279	82439279	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:82439279C>T	ENST00000360464.4	-	3	386	c.324G>A	c.(322-324)aaG>aaA	p.K108K	RP11-257P3.3_ENST00000523380.1_RNA	NM_001105281.1	NP_001098751.1	A6NFH5	FBP12_HUMAN	fatty acid binding protein 12	108							lipid binding|transporter activity			large_intestine(1)|lung(3)	4						CATCCACCAGCTTTCTCGTTA	0.408000													9	8					0	0	1	0	0
OR12D3	81797	broad.mit.edu	37	6	29342287	29342287	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:29342287G>A	ENST00000396806.3	-	1	781	c.778C>T	c.(778-780)Cgt>Tgt	p.R260C	OR5V1_ENST00000377154.1_Intron	NM_030959.2	NP_112221.1	Q9UGF7	O12D3_HUMAN	olfactory receptor, family 12, subfamily D, member 3	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)	23						GAAGCAGGACGAATATATGTG	0.488000													53	26					0	0	1	0	0
KCNK17	89822	broad.mit.edu	37	6	39267425	39267425	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:39267425G>A	ENST00000373231.4	-	5	1009	c.777C>T	c.(775-777)atC>atT	p.I259I	KCNK17_ENST00000453413.2_3'UTR	NM_031460.3	NP_113648.2	Q96T54	KCNKH_HUMAN	potassium channel, subfamily K, member 17	259						integral to membrane	potassium channel activity|voltage-gated ion channel activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(2)	14						TGAGTTTGATGATCAAGGCCA	0.557000													18	110					0	0	1	0	0
TSHB	7252	broad.mit.edu	37	1	115576082	115576082	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:115576082G>A	ENST00000256592.1	+	2	167	c.99G>A	c.(97-99)agG>agA	p.R33R	TSHB_ENST00000369517.1_Silent_p.R33R	NM_000549.3|NM_001277991.1	NP_000540.2|NP_001264920.1	P01222	TSHB_HUMAN	thyroid stimulating hormone, beta	33					anatomical structure morphogenesis|cell-cell signaling|cellular nitrogen compound metabolic process|G-protein coupled receptor protein signaling pathway|hormone biosynthetic process|peptide hormone processing	extracellular region	hormone activity			breast(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)	7	Lung SC(450;0.211)	all_cancers(81;3.22e-07)|all_epithelial(167;1.4e-06)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)		ACATCGAAAGGAGAGAGTGTG	0.423000													83	40					0	0	1	0	0
OR52B4	143496	broad.mit.edu	37	11	4389234	4389234	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:4389234G>A	ENST00000408920.2	-	1	382	c.292C>T	c.(292-294)Cgt>Tgt	p.R98C		NM_001005161.3	NP_001005161.2	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B, member 4	98					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(3)|large_intestine(7)|lung(15)|skin(2)	31		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		GTGATGCAACGATCCAGGGAG	0.527000													8	21					0	0	1	0	0
ZNF254	9534	broad.mit.edu	37	19	24310674	24310674	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:24310674T>A	ENST00000357002.4	+	4	1987	c.1872T>A	c.(1870-1872)caT>caA	p.H624Q	ZNF254_ENST00000342944.6_Missense_Mutation_p.H539Q	NM_001278661.1|NM_001278662.1|NM_001278664.1|NM_001278677.1|NM_001278678.1|NM_203282.2	NP_001265590.1|NP_001265591.1|NP_001265593.1|NP_001265606.1|NP_001265607.1|NP_975011.3	O75437	ZN254_HUMAN	zinc finger protein 254	624					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				AGAGAATTCATACTGGAGAGC	0.388000													20	42					0	0	1	0	0
SLC29A2	3177	broad.mit.edu	37	11	66131733	66131733	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:66131733C>T	ENST00000357440.2	-	11	1450	c.1222G>A	c.(1222-1224)Ggc>Agc	p.G408S	RP11-867G23.8_ENST00000580881.1_Intron|SLC29A2_ENST00000546034.1_Missense_Mutation_p.G408S|SLC29A2_ENST00000544554.1_Missense_Mutation_p.G408S|SLC29A2_ENST00000311161.7_3'UTR	NM_001532.2	NP_001523.2	Q14542	S29A2_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 2	408					cell proliferation|nucleobase, nucleoside and nucleotide metabolic process	basolateral plasma membrane|integral to plasma membrane|nuclear membrane|nucleolus	nucleoside transmembrane transporter activity			breast(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	10						ACCAGGTAGCCATTAGAAACG	0.617000											OREG0021103	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	7					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38771051	38771051	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:38771051G>A	ENST00000359357.3	+	20	2601	c.2347G>A	c.(2347-2349)Gaa>Aaa	p.E783K	DNAH8_ENST00000449981.2_Missense_Mutation_p.E1000K|DNAH8_ENST00000441566.1_Missense_Mutation_p.E783K					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GCAGATTTATGAAGTGAAATA	0.358000													8	36					0	0	1	0	0
SIRPB1	10326	broad.mit.edu	37	20	1559294	1559294	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:1559294G>A	ENST00000381605.4	-	2	187	c.123C>T	c.(121-123)tcC>tcT	p.S41S	SIRPB1_ENST00000262929.5_Silent_p.S40S|RP4-576H24.4_ENST00000564763.1_Silent_p.S41S|SIRPB1_ENST00000381603.3_Silent_p.S41S	NM_006065.3	NP_006056.2	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	41	Ig-like V-type.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						CAACTGATACGGACTTTTCAG	0.542000													70	59					0	0	1	0	0
TMEM132D	121256	broad.mit.edu	37	12	129558525	129558525	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:129558525G>A	ENST00000422113.2	-	9	3521	c.3195C>T	c.(3193-3195)atC>atT	p.I1065I	TMEM132D_ENST00000389441.4_Silent_p.I603I	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	1065						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TACTCATCACGATGGAGTTCC	0.517000													34	32					0	0	1	0	0
ABCA1	19	broad.mit.edu	37	9	107624034	107624034	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:107624034A>G	ENST00000374736.3	-	6	863	c.469T>C	c.(469-471)Ttc>Ctc	p.F157L	ABCA1_ENST00000374733.1_Missense_Mutation_p.F97L|ABCA1_ENST00000423487.2_Missense_Mutation_p.F157L	NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	157					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TGATACAGGAACCCAGAGAAG	0.398000													35	20					0	0	1	0	0
ARHGEF26	26084	broad.mit.edu	37	3	153840443	153840443	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:153840443C>T	ENST00000356448.4	+	2	946	c.662C>T	c.(661-663)cCc>cTc	p.P221L	ARHGEF26_ENST00000465093.1_Missense_Mutation_p.P221L|ARHGEF26_ENST00000465817.1_Missense_Mutation_p.P221L	NM_001251962.1	NP_001238891.1	Q96DR7	ARHGQ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 26	221					regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	23						CAAAGGCTGCCCTCCCAGGAG	0.587000													18	15					0	0	1	0	0
DARS	1615	broad.mit.edu	37	2	136700969	136700969	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:136700969G>A	ENST00000264161.4	-	5	617	c.402C>T	c.(400-402)gaC>gaT	p.D134D	DARS_ENST00000537273.1_Silent_p.D34D|DARS_ENST00000463008.1_5'UTR	NM_001349.2	NP_001340.2	P14868	SYDC_HUMAN	aspartyl-tRNA synthetase	134					aspartyl-tRNA aminoacylation|protein complex assembly	cytosol|nuclear membrane|plasma membrane|soluble fraction	aminoacylase activity|aspartate-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|urinary_tract(2)	15				BRCA - Breast invasive adenocarcinoma(221;0.168)	L-Aspartic Acid(DB00128)	GTAACTCAACGTCTTGCTGTG	0.323000													79	30					0	0	1	0	0
HMGB1P5	10354	broad.mit.edu	37	3	22424107	22424107	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:22424107G>A	ENST00000451497.1	+	0	672																											ACACACTACCGAATGTGTCTT	0.348000													6	3					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28992914	28992914	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr18:28992914G>A	ENST00000359747.4	+	15	2565	c.2536G>A	c.(2536-2538)Gac>Aac	p.D846N	RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581856.1_RNA|DSG4_ENST00000308128.4_Missense_Mutation_p.D827N	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	827					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GATTGTGGATGACTTAGATGA	0.453000													43	55					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101765855	101765855	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:101765855G>A	ENST00000375001.3	+	8	1609	c.1186G>A	c.(1186-1188)Gaa>Aaa	p.E396K		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	396	4 X tandem repeats.|Nonhelical region 1 (NC1).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				GAACCCAGAGGAAGGGGTCAC	0.617000													13	32					0	0	1	0	0
DPPA3P2	400206	broad.mit.edu	37	14	36841045	36841045	+	RNA	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:36841045C>T	ENST00000557188.1	+	0	676																											TGGATGGGATCCTTCTGAGAA	0.398000													60	45					0	0	1	0	0
BCL6	604	broad.mit.edu	37	3	187444628	187444628	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:187444628G>A	ENST00000406870.2	-	7	1965	c.1599C>T	c.(1597-1599)ctC>ctT	p.L533L	RP11-211G3.3_ENST00000437407.1_Intron|BCL6_ENST00000232014.4_Silent_p.L533L|BCL6_ENST00000450123.2_Intron|RP11-211G3.3_ENST00000449623.1_Intron	NM_001706.4	NP_001697.2	P41182	BCL6_HUMAN	B-cell CLL/lymphoma 6	533					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(9)|lung(10)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	40	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		TGTGCCTCTTGAGTGAGGCCT	0.597000			"""T, Mis"""	"""IG loci, ZNFN1A1, LCP1, PIM1, TFRC, CIITA, NACA, HSPCB, HSPCA, HIST1H4I, IL21R,  POU2AF1, ARHH, EIF4A2, SFRS3"""	"""NHL, CLL"""								16	42					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103461554	103461554	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:103461554C>T	ENST00000358392.2	-	27	2639	c.2322G>A	c.(2320-2322)cgG>cgA	p.R774R	COL11A1_ENST00000353414.4_Silent_p.R723R|COL11A1_ENST00000512756.1_Silent_p.R646R|COL11A1_ENST00000370096.3_Silent_p.R762R	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	762	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCTTTACTCCCCGGGGGCCCG	0.383000													64	24					0	0	1	0	0
SIGLEC6	946	broad.mit.edu	37	19	52034617	52034617	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:52034617G>A	ENST00000346477.3	-	2	292	c.224C>T	c.(223-225)cCa>cTa	p.P75L	SIGLEC6_ENST00000425629.3_Missense_Mutation_p.P75L|SIGLEC6_ENST00000343300.4_Missense_Mutation_p.P75L|SIGLEC6_ENST00000391797.3_Missense_Mutation_p.P75L|SIGLEC6_ENST00000436458.1_Missense_Mutation_p.P39L|SIGLEC6_ENST00000359982.4_Missense_Mutation_p.P75L	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	75	Ig-like V-type.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		TGTGGCCACTGGAACATCAGC	0.587000													33	25					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179616450	179616450	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:179616450G>A	ENST00000360870.5	-	46	10899	c.10677C>T	c.(10675-10677)caC>caT	p.H3559H	TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000590773.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	3558	Ig-like 21.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAGAGTGATGGTGTAAATCAC	0.413000													26	83					0	0	1	0	0
CD320	51293	broad.mit.edu	37	19	8367350	8367350	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:8367350G>A	ENST00000301458.5	-	5	910	c.846C>T	c.(844-846)ccC>ccT	p.P282P	CD320_ENST00000537716.2_Silent_p.P240P	NM_016579.3	NP_057663.1	Q9NPF0	CD320_HUMAN	CD320 molecule	282					regulation of cell growth	endoplasmic reticulum|integral to membrane	growth factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)	6						CTTGTCCTCAGGGCAGCGAGG	0.642000													15	60					0	0	1	0	0
DUS2	54920	broad.mit.edu	37	16	68109264	68109264	+	Silent	SNP	C	C	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:68109264C>A	ENST00000565263.1	+	14	1433	c.939C>A	c.(937-939)gcC>gcA	p.A313A	DUS2L_ENST00000432752.1_Silent_p.A278A|DUS2L_ENST00000358896.6_Silent_p.A313A	NM_017803.3	NP_060273.1	Q9NX74	DUS2L_HUMAN		313					tRNA processing	endoplasmic reticulum	double-stranded RNA binding|flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|stomach(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0131)|Epithelial(162;0.0564)		CTAGTGAGGCCTTTGGCCTTG	0.592000													15	24					2.31682e-05	2.33113e-05	1	1	0
FAM81B	153643	broad.mit.edu	37	5	94727108	94727108	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:94727108C>T	ENST00000283357.5	+	1	61	c.15C>T	c.(13-15)ttC>ttT	p.F5F		NM_152548.2	NP_689761.2	Q96LP2	FA81B_HUMAN	family with sequence similarity 81, member B	5								p.F5F(1)		central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		AATTACAATTCCTTGGTACAT	0.378000													26	6					0	0	1	0	0
TCF7L1	83439	broad.mit.edu	37	2	85510672	85510672	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:85510672G>A	ENST00000282111.3	+	4	771	c.496G>A	c.(496-498)Gac>Aac	p.D166N		NM_031283.2	NP_112573.1	Q9HCS4	TF7L1_HUMAN	transcription factor 7-like 1 (T-cell specific, HMG-box)	166	Pro-rich.				chromatin organization|regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|skin(4)|upper_aerodigestive_tract(1)	18						CACAGTCAAGGACACGAGGTC	0.532000													23	152					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100392956	100392956	+	RNA	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:100392956C>T	ENST00000542585.1	+	0	8474				ZAN_ENST00000427578.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546213.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCCAGAAAGCCAGGTGAGGGC	0.532000													5	11					0	0	1	0	0
GPR123	84435	broad.mit.edu	37	10	134885485	134885485	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:134885485G>A	ENST00000607359.1	+	2	244	c.244G>A	c.(244-246)Gag>Aag	p.E82K				Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	0						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		GGCCGAGGGCGAGCCCTCATG	0.642000													8	3					0	0	1	0	0
GYPB	2994	broad.mit.edu	37	4	144922398	144922398	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:144922398C>T	ENST00000283126.7	-	2	131	c.76G>A	c.(76-78)Gca>Aca	p.A26T	GYPB_ENST00000502664.1_Missense_Mutation_p.A26T|GYPB_ENST00000429670.2_Missense_Mutation_p.A26T|GYPB_ENST00000510196.2_5'UTR|GYPB_ENST00000513128.1_Intron|RP11-673E1.4_ENST00000506982.1_RNA					glycophorin B (MNS blood group)											breast(1)|large_intestine(2)|skin(1)	4	all_hematologic(180;0.158)					GTGTGCATTGCCACCTCAGTG	0.368000													16	79					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92761354	92761354	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:92761354C>T	ENST00000318238.4	-	5	5147	c.3931G>A	c.(3931-3933)Gat>Aat	p.D1311N	SAMD9L_ENST00000411955.1_Missense_Mutation_p.D1311N|SAMD9L_ENST00000437805.1_Missense_Mutation_p.D1311N	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1311										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			AGACATGGATCCAAATGACAG	0.378000													11	37					0	0	1	0	0
C19orf18	147685	broad.mit.edu	37	19	58485728	58485728	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:58485728G>A	ENST00000314391.3	-	1	174	c.73C>T	c.(73-75)Ccg>Tcg	p.P25S		NM_152474.4	NP_689687.1	Q8NEA5	CS018_HUMAN	chromosome 19 open reading frame 18	25						integral to membrane				large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	8		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)		TCTGCATACGGCAAGCATAAA	0.398000													40	24					0	0	1	0	0
CNN1	1264	broad.mit.edu	37	19	11658686	11658686	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:11658686G>A	ENST00000592923.1	+	6	892	c.315G>A	c.(313-315)ggG>ggA	p.G105G	CNN1_ENST00000535659.2_Silent_p.G105G|CNN1_ENST00000544952.1_Silent_p.G135G|CNN1_ENST00000252456.2_Silent_p.G155G			P51911	CNN1_HUMAN	calponin 1, basic, smooth muscle	155	CH.				actomyosin structure organization|regulation of smooth muscle contraction	cytoskeleton	actin binding|calmodulin binding			breast(1)|endometrium(2)|large_intestine(4)|lung(2)	9						TCGAGCCGGGGAAGCTAAGAG	0.587000													15	19					0	0	1	0	0
VRTN	55237	broad.mit.edu	37	14	74824785	74824785	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:74824785G>A	ENST00000256362.4	+	2	1540	c.1299G>A	c.(1297-1299)cgG>cgA	p.R433R		NM_018228.2	NP_060698.2	Q9H8Y1	VRTN_HUMAN	vertebrae development associated	433					transposition, DNA-mediated		DNA binding|transposase activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(15)|ovary(5)|prostate(2)|skin(1)|urinary_tract(1)	41						GCATCTCACGGTCCACTTATT	0.572000													45	34					0	0	1	0	0
OR4M2	390538	broad.mit.edu	37	15	22369074	22369074	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr15:22369074C>T	ENST00000332663.2	+	1	597	c.499C>T	c.(499-501)Cct>Tct	p.P167S	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P167A(1)		NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TGTTCGACTTCCTTTCTGTGG	0.493000													74	25					0	0	1	0	0
OSTM1	28962	broad.mit.edu	37	6	108395683	108395683	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:108395683A>G	ENST00000193322.3	-	1	258	c.173T>C	c.(172-174)tTg>tCg	p.L58S		NM_014028.3	NP_054747.2	Q86WC4	OSTM1_HUMAN	osteopetrosis associated transmembrane protein 1	58						integral to membrane				central_nervous_system(2)|endometrium(1)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	8		all_cancers(87;3.82e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000195)|Colorectal(196;0.0293)|all_lung(197;0.0938)		BRCA - Breast invasive adenocarcinoma(108;0.0131)|Epithelial(106;0.0438)|OV - Ovarian serous cystadenocarcinoma(136;0.0571)|all cancers(137;0.0581)		GGACAGGGACAAGTCCTCCAC	0.692000													4	1					0	0	1	0	0
MGRN1	23295	broad.mit.edu	37	16	4731625	4731625	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:4731625C>T	ENST00000399577.5	+	13	1299	c.1206C>T	c.(1204-1206)tcC>tcT	p.S402S	MGRN1_ENST00000588994.1_Silent_p.S380S|MGRN1_ENST00000586183.1_Silent_p.S380S|MGRN1_ENST00000262370.7_Silent_p.S402S|MGRN1_ENST00000415496.1_Silent_p.S381S	NM_001142290.2	NP_001135762.1	O60291	MGRN1_HUMAN	mahogunin ring finger 1, E3 ubiquitin protein ligase	402					endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18						GGGCTGTCTCCCCGGCCATCC	0.647000													32	42					0	0	1	0	0
DEPDC5	9681	broad.mit.edu	37	22	32215149	32215149	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:32215149C>T	ENST00000400246.1	+	22	1950	c.1808C>T	c.(1807-1809)cCc>cTc	p.P603L	DEPDC5_ENST00000536766.1_Missense_Mutation_p.P575L|DEPDC5_ENST00000266091.3_Missense_Mutation_p.P603L|DEPDC5_ENST00000400249.2_Missense_Mutation_p.P603L|DEPDC5_ENST00000382112.3_Missense_Mutation_p.P603L|DEPDC5_ENST00000535622.1_Missense_Mutation_p.P603L|DEPDC5_ENST00000382111.2_Missense_Mutation_p.P603L|DEPDC5_ENST00000400248.1_Missense_Mutation_p.P603L|DEPDC5_ENST00000382105.2_Missense_Mutation_p.P603L			O75140	DEPD5_HUMAN	DEP domain containing 5	603					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						CCCTTCGCTCCCTCTCGGATG	0.542000													56	86					0	0	1	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41751801	41751801	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:41751801G>A	ENST00000352645.4	+	19	2466	c.2209G>A	c.(2209-2211)Gcc>Acc	p.A737T	ZC3H7B_ENST00000351589.4_Missense_Mutation_p.A737T	NM_017590.4	NP_060060.3	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	753					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						GATGTCCAAGGCCAAGAGGAA	0.617000													9	18					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62453097	62453097	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:62453097C>T	ENST00000512091.1	+	4	955	c.208C>T	c.(208-210)Cct>Tct	p.P70S	LPHN3_ENST00000514996.1_Missense_Mutation_p.P70S|LPHN3_ENST00000506700.1_Missense_Mutation_p.P70S|LPHN3_ENST00000514591.1_Missense_Mutation_p.P70S|LPHN3_ENST00000514157.1_Missense_Mutation_p.P70S|LPHN3_ENST00000511324.1_Missense_Mutation_p.P138S|LPHN3_ENST00000507164.1_Missense_Mutation_p.P138S|LPHN3_ENST00000506720.1_Missense_Mutation_p.P138S|LPHN3_ENST00000506746.1_Missense_Mutation_p.P138S|LPHN3_ENST00000545650.1_Missense_Mutation_p.P70S|LPHN3_ENST00000508693.1_Missense_Mutation_p.P138S|LPHN3_ENST00000509896.1_Missense_Mutation_p.P138S|LPHN3_ENST00000504896.1_Missense_Mutation_p.P70S|LPHN3_ENST00000507625.1_Missense_Mutation_p.P138S|LPHN3_ENST00000508946.1_Missense_Mutation_p.P70S			Q9HAR2	LPHN3_HUMAN	latrophilin 3	70	SUEL-type lectin.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						TGACTCTGACCCTGCTCAGAT	0.403000													6	21					0	0	1	0	0
OLFM2	93145	broad.mit.edu	37	19	9968508	9968508	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:9968508G>A	ENST00000264833.4	-	3	428	c.243C>T	c.(241-243)gtC>gtT	p.V81V	OLFM2_ENST00000590841.1_Silent_p.V3V	NM_058164.2	NP_477512.1	O95897	NOE2_HUMAN	olfactomedin 2	81						extracellular region				breast(1)|cervix(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	31						GCAACTCAAGGACCTCCATGG	0.602000													8	35					0	0	1	0	0
PPIH	10465	broad.mit.edu	37	1	43130609	43130609	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:43130609C>T	ENST00000455203.2	+	4	618	c.190C>T	c.(190-192)Cca>Tca	p.P64S	PPIH_ENST00000304979.3_Missense_Mutation_p.P107S|PPIH_ENST00000372550.1_Missense_Mutation_p.P64S			O43447	PPIH_HUMAN	peptidylprolyl isomerase H (cyclophilin H)	107	PPIase cyclophilin-type.				protein complex assembly|protein folding	cytoplasm|nuclear speck|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|ribonucleoprotein binding			endometrium(1)|large_intestine(1)|lung(2)	4	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)			L-Proline(DB00172)	ACACTCAGCTCCAGGCCTGCT	0.502000													31	16					0	0	1	0	0
PKNOX2	63876	broad.mit.edu	37	11	125267885	125267885	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:125267885G>A	ENST00000298282.9	+	7	786	c.515G>A	c.(514-516)aGc>aAc	p.S172N	PKNOX2_ENST00000542175.1_Missense_Mutation_p.S108N|PKNOX2_ENST00000530517.1_3'UTR	NM_022062.2	NP_071345.2	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	172						nucleus	sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(14)|ovary(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	29		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		AAGATGCACAGCGACAACCTG	0.537000													16	47					0	0	1	0	0
GLMN	11146	broad.mit.edu	37	1	92712635	92712635	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:92712635G>A	ENST00000370360.3	-	18	1733	c.1652C>T	c.(1651-1653)cCt>cTt	p.P551L	GLMN_ENST00000534881.1_Missense_Mutation_p.P537L	NM_053274.2	NP_444504.1	Q92990	GLMN_HUMAN	glomulin, FKBP associated protein	551					muscle cell differentiation|negative regulation of T cell proliferation|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of phosphorylation|regulation of gene expression, epigenetic|vasculogenesis	intracellular	hepatocyte growth factor receptor binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)	17		all_lung(203;0.00827)|Lung NSC(277;0.0295)		all cancers(265;0.00702)|GBM - Glioblastoma multiforme(16;0.0381)|Epithelial(280;0.0989)		CTGCATTTCAGGAGGCATATT	0.393000									Multiple Glomus Tumors (of the Skin), Familial				112	39					0	0	1	0	0
OR4C13	283092	broad.mit.edu	37	11	49974850	49974850	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:49974850G>A	ENST00000555099.1	+	1	908	c.876G>A	c.(874-876)atG>atA	p.M292I		NM_001001955.2	NP_001001955.2	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C, member 13	292					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	43						ATGCTCAAATGAAAAATGCCA	0.383000													32	27					0	0	1	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17698588	17698588	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:17698588C>T	ENST00000399080.2	-	1	1118	c.1095G>A	c.(1093-1095)aaG>aaA	p.K365K		NM_001099218.2	NP_001092688.1	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	365										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(10)|liver(1)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TAGCGAAATTCTTTCTAGAGT	0.388000													11	66					0	0	1	0	0
CASKIN1	57524	broad.mit.edu	37	16	2235405	2235405	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:2235405G>A	ENST00000343516.6	-	11	1145	c.1053C>T	c.(1051-1053)tcC>tcT	p.S351S		NM_020764.3	NP_065815.1	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	351					signal transduction	cytoplasm				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|liver(1)|lung(7)|ovary(4)|prostate(5)|skin(3)	28						TGCCTGCTCGGGAACCTGTGG	0.642000													16	13					0	0	1	0	0
TNIK	23043	broad.mit.edu	37	3	170858197	170858197	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:170858197C>T	ENST00000436636.2	-	13	1667	c.1323G>A	c.(1321-1323)gaG>gaA	p.E441E	TNIK_ENST00000284483.8_Silent_p.E441E|TNIK_ENST00000488470.1_Silent_p.E441E|TNIK_ENST00000341852.6_Silent_p.E441E|TNIK_ENST00000369326.5_Silent_p.E441E|TNIK_ENST00000475336.1_Silent_p.E441E|TNIK_ENST00000460047.1_Silent_p.E441E|TNIK_ENST00000357327.5_Silent_p.E441E|TNIK_ENST00000470834.1_Silent_p.E441E|TNIK_ENST00000538048.1_Silent_p.E441E	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	441	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			CCTGTTCATGCTCCGCACGCC	0.642000													38	90					0	0	1	0	0
GPT2	84706	broad.mit.edu	37	16	46943618	46943618	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:46943618C>T	ENST00000440783.2	+	6	964	c.299C>T	c.(298-300)tCc>tTc	p.S100F	GPT2_ENST00000340124.4_Missense_Mutation_p.S200F	NM_001142466.1	NP_001135938.1	Q8TD30	ALAT2_HUMAN	glutamic pyruvate transaminase (alanine aminotransferase) 2	200					2-oxoglutarate metabolic process|cellular amino acid biosynthetic process|L-alanine metabolic process	mitochondrial matrix	L-alanine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(2)	23		all_cancers(37;0.0276)|all_epithelial(9;0.0498)|all_lung(18;0.0522)			L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	ATCCTCGTCTCCGGGGGCGGC	0.547000													27	22					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196834804	196834804	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:196834804C>T	ENST00000312428.6	-	17	2173	c.2073G>A	c.(2071-2073)cgG>cgA	p.R691R		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	691	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CCTCCACAAACCGTTCACACC	0.328000													34	21					0	0	1	0	0
ASRGL1	80150	broad.mit.edu	37	11	62159752	62159752	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:62159752C>T	ENST00000415229.2	+	7	1138	c.923C>T	c.(922-924)cCc>cTc	p.P308L	CTD-2531D15.5_ENST00000526045.1_RNA|ASRGL1_ENST00000301776.5_Missense_Mutation_p.P308L	NM_001083926.1	NP_001077395.1	Q7L266	ASGL1_HUMAN	asparaginase like 1	308					asparagine catabolic process via L-aspartate|protein maturation	cytoplasm|microtubule cytoskeleton|nucleus	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity			endometrium(1)|kidney(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	7					L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)	ACCGACCTTCCCTAAGCCGCT	0.493000													9	24					0	0	1	0	0
RPRM	56475	broad.mit.edu	37	2	154334949	154334949	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:154334949C>T	ENST00000325926.3	-	1	373	c.131G>A	c.(130-132)gGa>gAa	p.G44E	AC012501.2_ENST00000424322.1_RNA	NM_019845.2	NP_062819.1	Q9NS64	RPRM_HUMAN	reprimo, TP53 dependent G2 arrest mediator candidate	44					cell cycle arrest	cytoplasm|integral to membrane	protein binding			large_intestine(2)|lung(1)|prostate(1)	4						GTCCGGGCCTCCCTCCGCGAA	0.672000													15	50					0	0	1	0	0
PACS1	55690	broad.mit.edu	37	11	65978657	65978657	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:65978657G>A	ENST00000320580.4	+	4	620	c.587G>A	c.(586-588)aGg>aAg	p.R196K		NM_018026.3	NP_060496.2	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	196				Missing (in Ref. 2; BAC04831).	interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding		RBM14/PACS1(2)	breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(8)|ovary(6)|skin(2)|urinary_tract(1)	37						ATGCTGCAAAGGAGAAAACGT	0.493000													86	61					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	118949816	118949816	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:118949816G>A	ENST00000328252.3	+	2	1168	c.799G>A	c.(799-801)Gag>Aag	p.E267K		NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	267					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						GACTCAGCGGGAGATACTGTC	0.567000													18	67					0	0	1	0	0
LEPREL4	10609	broad.mit.edu	37	17	39966033	39966033	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:39966033G>A	ENST00000355468.3	-	5	1307	c.841C>T	c.(841-843)Ccc>Tcc	p.P281S	LEPREL4_ENST00000393928.1_Missense_Mutation_p.P281S			Q92791	SC65_HUMAN	leprecan-like 4	281					synaptonemal complex assembly	nucleolus|synaptonemal complex	binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|urinary_tract(1)	8						CCCACATTGGGGGTCAAATTG	0.557000													40	8					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31383763	31383763	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:31383763C>T	ENST00000268296.4	+	18	2346	c.2225C>T	c.(2224-2226)cCc>cTc	p.P742L	ITGAX_ENST00000562522.1_Missense_Mutation_p.P742L	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	742					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						GTGGGCAAGCCCCTCCTTGCC	0.642000													40	58					0	0	1	0	0
SERPINB2	5055	broad.mit.edu	37	18	61564346	61564346	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr18:61564346C>T	ENST00000457692.1	+	5	643	c.310C>T	c.(310-312)Cat>Tat	p.H104Y	SERPINB2_ENST00000299502.4_Missense_Mutation_p.H104Y|SERPINB2_ENST00000482254.1_3'UTR	NM_001143818.1	NP_001137290.1	P05120	PAI2_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 2	104					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|liver(1)|lung(12)|prostate(2)|skin(2)|stomach(1)	32		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	AGATAAAATCCATTCATCCTT	0.378000													19	44					0	0	1	0	0
IGLV1-47	28822	broad.mit.edu	37	22	22712439	22712439	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:22712439G>A	ENST00000390294.2	+	0	238																											CAGCTCCCAGGAACGGCCCCC	0.572000													70	108					0	0	1	0	0
TNFRSF21	27242	broad.mit.edu	37	6	47253756	47253756	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:47253756G>A	ENST00000296861.2	-	2	1065	c.672C>T	c.(670-672)tcC>tcT	p.S224S		NM_014452.3	NP_055267.1	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily, member 21	224					cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(7)|pancreas(1)|skin(2)	21			Lung(136;0.189)			CTGTGCCAGGGGAAGGTGAGG	0.527000													3	35					0	0	1	0	0
MALSU1	115416	broad.mit.edu	37	7	23339025	23339025	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:23339025G>A	ENST00000466681.1	+	1	207	c.54G>A	c.(52-54)agG>agA	p.R18R	MALSU1_ENST00000479974.1_Intron	NM_138446.1	NP_612455.1	Q96EH3	CG030_HUMAN	mitochondrial assembly of ribosomal large subunit 1	18						mitochondrion											TGTGGCGCAGGGCGGTTTCCT	0.721000													6	10					0	0	1	0	0
LRIG3	121227	broad.mit.edu	37	12	59266363	59266363	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:59266363C>T	ENST00000320743.3	-	19	3637	c.3351G>A	c.(3349-3351)ttG>ttA	p.L1117L	LRIG3_ENST00000379141.4_Silent_p.L1057L	NM_153377.4	NP_700356.2	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like domains 3	1117						integral to membrane			LRIG3/ROS1(2)	breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(12)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48			GBM - Glioblastoma multiforme(1;1.17e-18)			TCTATGTGTCCAAGTCATAAG	0.323000			T	ROS1	NSCLC								20	16					0	0	1	0	0
ZNF12	7559	broad.mit.edu	37	7	6731972	6731972	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:6731972G>A	ENST00000405858.1	-	5	1142	c.601C>T	c.(601-603)Cta>Tta	p.L201L	ZNF12_ENST00000342651.5_Silent_p.L163L|AC073343.13_ENST00000366167.2_RNA|ZNF12_ENST00000404360.1_Silent_p.L127L	NM_006956.2|NM_016265.3	NP_008887.2|NP_057349.2	P17014	ZNF12_HUMAN	zinc finger protein 12	201					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|endometrium(1)|large_intestine(1)|lung(7)|prostate(2)|upper_aerodigestive_tract(3)	16		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		TCTTCATTTAGAGTATAAGGT	0.338000													4	8					0	0	1	0	0
SOWAHD	347454	broad.mit.edu	37	X	118892654	118892654	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:118892654G>A	ENST00000343905.3	+	1	79	c.24G>A	c.(22-24)gcG>gcA	p.A8A		NM_001105576.2	NP_001099046.1	A6NJG2	ANR58_HUMAN	sosondowah ankyrin repeat domain family member D	8																	GAGGGGCCGCGAACCGGGCAC	0.731000													4	2					0	0	1	0	0
MPO	4353	broad.mit.edu	37	17	56349180	56349180	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:56349180C>T	ENST00000340482.3	-	10	2138	c.1962G>A	c.(1960-1962)agG>agA	p.R654R	MPO_ENST00000225275.3_Silent_p.R622R			P05164	PERM_HUMAN	myeloperoxidase	622					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	ATTTCAGGTTCCTCAGCACCG	0.612000													60	14					0	0	1	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2306447	2306447	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:2306447G>A	ENST00000290974.2	-	8	1959	c.1620C>T	c.(1618-1620)ccC>ccT	p.P540P	RP11-478C1.7_ENST00000510632.1_RNA|ZFYVE28_ENST00000515312.1_Silent_p.P470P|ZFYVE28_ENST00000511071.1_Silent_p.P510P	NM_020972.2	NP_066023.2	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	540					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	31						CCTCGGCCACGGGCTCCGAGG	0.662000													11	34					0	0	1	0	0
POC1A	25886	broad.mit.edu	37	3	52185054	52185054	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:52185054G>A	ENST00000394970.2	-	2	398	c.81C>T	c.(79-81)ttC>ttT	p.F27F	POC1A_ENST00000474012.1_5'UTR|POC1A_ENST00000296484.2_Silent_p.F27F	NM_001161580.1	NP_001155052.1	Q8NBT0	POC1A_HUMAN	POC1 centriolar protein A	27						centriole|microtubule basal body				endometrium(1)|large_intestine(4)|liver(1)|lung(4)|prostate(3)|skin(1)	14						TGTTGATACTGAAGTCCACAC	0.537000													28	94					0	0	1	0	0
SWI5	375757	broad.mit.edu	37	9	131038442	131038442	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:131038442G>A	ENST00000320188.4	+	1	18	c.18G>A	c.(16-18)caG>caA	p.Q6Q		NM_001040011.1	NP_001035100.1	Q1ZZU3	SWI5_HUMAN	SWI5 recombination repair homolog (yeast)	6					double-strand break repair via homologous recombination	Swi5-Sfr1 complex	protein binding										GGCGTGGCCAGAGGGACCTGT	0.647000													32	82					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21230954	21230954	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:21230954C>T	ENST00000233242.1	-	26	8913	c.8786G>A	c.(8785-8787)tGg>tAg	p.W2929*		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2929					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GGCCCATTTCCATGACCCTTT	0.483000													105	40					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103339406	103339406	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:103339406C>T	ENST00000375735.2	+	88	12882	c.12738C>T	c.(12736-12738)ctC>ctT	p.L4246L	DYNC2H1_ENST00000334267.7_Silent_p.L859L|DYNC2H1_ENST00000398093.3_Silent_p.L4253L	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	4246					cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		CATCAGTGCTCCCTTGTTTTA	0.368000													9	8					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110424524	110424524	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:110424524G>A	ENST00000378402.5	+	20	2220	c.2116G>A	c.(2116-2118)Gaa>Aaa	p.E706K		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	706					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GAAGACAGCTGAAACCGATGC	0.398000										HNSCC(38;0.096)			11	21					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109379908	109379908	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:109379908G>A	ENST00000356711.2	+	4	544	c.418G>A	c.(418-420)Gat>Aat	p.D140N	MYO16_ENST00000357550.2_Missense_Mutation_p.D140N|MYO16_ENST00000251041.5_Missense_Mutation_p.D140N	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	140					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CGATAACCCTGATATTGTCCT	0.393000													14	54					0	0	1	0	0
PRKCQ	5588	broad.mit.edu	37	10	6553153	6553153	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:6553153T>C	ENST00000263125.5	-	3	221	c.122A>G	c.(121-123)aAc>aGc	p.N41S	PRKCQ_ENST00000539722.1_5'UTR|PRKCQ_ENST00000397176.2_Missense_Mutation_p.N41S	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	41	C2.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						CATCTGCCCGTTCTCTAGGAA	0.463000													37	7					0	0	1	0	0
NOA1	84273	broad.mit.edu	37	4	57842672	57842672	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:57842672C>T	ENST00000264230.4	-	1	2317	c.1080G>A	c.(1078-1080)gaG>gaA	p.E360E		NM_032313.2	NP_115689.1	Q8NC60	CD014_HUMAN	nitric oxide associated 1	360							GTP binding										AGTAATCGGACTCCAGGAGCG	0.602000													21	20					0	0	1	0	0
FAM46A	55603	broad.mit.edu	37	6	82459715	82459715	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:82459715G>A	ENST00000369754.3	-	3	1395	c.1083C>T	c.(1081-1083)aaC>aaT	p.N361N	FAM46A_ENST00000320172.6_Silent_p.N342N|FAM46A_ENST00000369756.3_Silent_p.N423N			Q96IP4	FA46A_HUMAN	family with sequence similarity 46, member A	342										endometrium(2)|large_intestine(3)|lung(5)|skin(1)|urinary_tract(1)	12		all_cancers(76;6.74e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000282)|all_epithelial(107;0.0104)		BRCA - Breast invasive adenocarcinoma(397;0.0428)		CCACAAAGTGGTTCTGCAAAT	0.443000													11	20					0	0	1	0	0
LTBP3	4054	broad.mit.edu	37	11	65321711	65321711	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:65321711G>A	ENST00000301873.5	-	2	740	c.472C>T	c.(472-474)Ctg>Ttg	p.L158L	LTBP3_ENST00000322147.4_Silent_p.L158L|LTBP3_ENST00000536982.1_Intron	NM_001130144.2	NP_001123616.1	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding protein 3	158	Gly-rich.					extracellular region	calcium ion binding|growth factor binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|prostate(2)|upper_aerodigestive_tract(3)	23						GTCCTGCTCAGGCCGGGGCCT	0.716000													4	14					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76563176	76563176	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:76563176G>A	ENST00000389840.5	-	10	1481	c.1357C>T	c.(1357-1359)Ctc>Ttc	p.L453F	DNAH17_ENST00000585328.1_Missense_Mutation_p.L453F					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			AGGCTCCCGAGGAGGTTCCCA	0.498000													15	2					0	0	1	0	0
EVC2	132884	broad.mit.edu	37	4	5667300	5667300	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:5667300G>A	ENST00000310917.2	-	8	1438	c.707C>T	c.(706-708)gCc>gTc	p.A236V	EVC2_ENST00000344938.1_Missense_Mutation_p.A316V|EVC2_ENST00000344408.5_Missense_Mutation_p.A316V	NM_001166136.1	NP_001159608.1	Q86UK5	LBN_HUMAN	Ellis van Creveld syndrome 2	316						integral to membrane				NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						GAGGAAGAGGGCAGCCCAGGT	0.572000													17	20					0	0	1	0	0
ALOX12	239	broad.mit.edu	37	17	6905007	6905007	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:6905007G>A	ENST00000251535.6	+	8	1091	c.1038G>A	c.(1036-1038)tgG>tgA	p.W346*	AC027763.2_ENST00000575727.1_Intron|RP11-589P10.7_ENST00000572547.1_RNA|AC027763.2_ENST00000399541.2_Intron|AC027763.2_ENST00000399540.2_3'UTR|AC027763.2_ENST00000574377.1_Intron	NM_000697.2	NP_000688.2	P18054	LOX12_HUMAN	arachidonate 12-lipoxygenase	346	Lipoxygenase.				anti-apoptosis|cellular component movement|fatty acid oxidation|leukotriene biosynthetic process|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of cell proliferation|superoxide anion generation	cytosol|sarcolemma	arachidonate 12-lipoxygenase activity|hepoxilin-epoxide hydrolase activity|iron ion binding|lipoxygenase activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(3)|urinary_tract(1)	19						CAAAGTCCTGGGTCCGAAATT	0.577000													140	16					0	0	1	0	0
CALML6	163688	broad.mit.edu	37	1	1848607	1848607	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:1848607G>A	ENST00000307786.3	+	6	975	c.521G>A	c.(520-522)gGg>gAg	p.G174E		NM_138705.2	NP_619650.2	Q8TD86	CALL6_HUMAN	calmodulin-like 6	174	EF-hand 4.					cytoplasm|nucleus	calcium ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(1)|prostate(2)	7	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.94e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.83e-23)|GBM - Glioblastoma multiforme(42;3.23e-08)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00437)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		ATGATGACGGGGGAGTCCTTC	0.697000													11	6					0	0	1	0	0
ANPEP	290	broad.mit.edu	37	15	90349308	90349308	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr15:90349308G>A	ENST00000300060.6	-	2	820	c.507C>T	c.(505-507)tcC>tcT	p.S169S		NM_001150.2	NP_001141.2	P15144	AMPN_HUMAN	alanyl (membrane) aminopeptidase	169	Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	57	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	CCTTCACCAGGGAGCCCTTGA	0.627000													71	15					0	0	1	0	0
LOC344967	344967	broad.mit.edu	37	4	40045344	40045344	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:40045344G>A	ENST00000381811.2	-	0	805					NR_027277.1																						GCTCCTGCCGGAAATACACAA	0.592000													10	17					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41078007	41078007	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:41078007A>C	ENST00000352632.3	+	34	7488	c.7402A>C	c.(7402-7404)Aca>Cca	p.T2468P	SPTBN4_ENST00000392025.1_Missense_Mutation_p.T1211P|SPTBN4_ENST00000593816.1_3'UTR|SPTBN4_ENST00000598249.1_Missense_Mutation_p.T2468P			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	2468	PH.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			ATCCGGGAGCACACACGGTGG	0.592000													112	94					0	0	1	0	0
AFAP1	60312	broad.mit.edu	37	4	7774552	7774552	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:7774552G>A	ENST00000420658.1	-	16	2520	c.2248C>T	c.(2248-2250)Cca>Tca	p.P750S	AFAP1_ENST00000360265.4_Missense_Mutation_p.P666S|AFAP1_ENST00000358461.2_Missense_Mutation_p.P666S|AFAP1_ENST00000513842.1_5'UTR|AFAP1_ENST00000382543.3_Missense_Mutation_p.P750S	NM_001134647.1	NP_001128119.1	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	666						actin cytoskeleton|cytoplasm|focal adhesion	actin binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(4)|stomach(2)	32						CACACCTGTGGACTCGATGTC	0.662000													8	28					0	0	1	0	0
AP3D1	8943	broad.mit.edu	37	19	2129389	2129389	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:2129389G>A	ENST00000355272.6	-	7	866	c.660C>T	c.(658-660)tcC>tcT	p.S220S	AP3D1_ENST00000356926.4_Intron|AP3D1_ENST00000345016.5_Silent_p.S220S|AP3D1_ENST00000590683.1_5'UTR|AP3D1_ENST00000350812.6_Intron	NM_001261826.1	NP_001248755.1	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1 subunit	220					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(23)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGGGGCCAGGGACAGGTAGT	0.572000													15	16					0	0	1	0	0
WNT7A	7476	broad.mit.edu	37	3	13860602	13860602	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:13860602T>G	ENST00000285018.4	-	4	1193	c.889A>C	c.(889-891)Acg>Ccg	p.T297P		NM_004625.3	NP_004616.2	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family, member 7A	297					activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	24						TGGGGAGCCGTCTTGTTGCAG	0.642000													18	30					0	0	1	0	0
ZNF683	257101	broad.mit.edu	37	1	26688453	26688453	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:26688453C>T	ENST00000436292.1	-	7	1384	c.1264G>A	c.(1264-1266)Ggg>Agg	p.G422R	ZNF683_ENST00000403843.1_Missense_Mutation_p.G422R|ZNF683_ENST00000374204.1_Missense_Mutation_p.G402R|ZNF683_ENST00000349618.3_Missense_Mutation_p.G402R			Q8IZ20	ZN683_HUMAN	zinc finger protein 683	422					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	15		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		GGCCGGGCCCCGGAGTGCAGG	0.642000													48	70					0	0	1	0	0
MAPK8	5599	broad.mit.edu	37	10	49633255	49633255	+	Nonsense_Mutation	SNP	T	T	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:49633255T>G	ENST00000374174.1	+	6	650	c.650T>G	c.(649-651)tTa>tGa	p.L217*	MAPK8_ENST00000374189.1_Intron|MAPK8_ENST00000395611.3_Intron|MAPK8_ENST00000360332.3_Intron|MAPK8_ENST00000374182.3_Intron			P45983	MK08_HUMAN	mitogen-activated protein kinase 8	0	Protein kinase.				activation of pro-apoptotic gene products|cellular response to mechanical stimulus|induction of apoptosis by intracellular signals|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of apoptosis|negative regulation of protein binding|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of deacetylase activity|regulation of protein localization|regulation of sequence-specific DNA binding transcription factor activity|response to UV|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|histone deacetylase binding|histone deacetylase regulator activity|JUN kinase activity|protein binding			breast(1)|central_nervous_system(3)|endometrium(4)|kidney(1)|large_intestine(6)|liver(3)|lung(11)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	34		Ovarian(717;0.0221)|Lung SC(717;0.113)|all_neural(218;0.116)		Epithelial(53;3.46e-65)|Lung(62;0.125)		TTCACAAGGTTACAATAAGTG	0.363000													4	1					0	0	1	0	0
C12orf77	196415	broad.mit.edu	37	12	25148862	25148862	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:25148862T>C	ENST00000549828.1	-	3	490	c.286A>G	c.(286-288)Act>Gct	p.T96A	C12orf77_ENST00000434912.3_Missense_Mutation_p.T41A|C12orf77_ENST00000549262.1_Missense_Mutation_p.T41A	NM_001101339.1	NP_001094809.1	C9JDV5	CL097_HUMAN	chromosome 12 open reading frame 77	96										endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)	7						GCTGTTTCAGTAGAGATGGCA	0.478000													24	12					0	0	1	0	0
RAG1	5896	broad.mit.edu	37	11	36597719	36597719	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:36597719C>T	ENST00000299440.5	+	2	2977	c.2865C>T	c.(2863-2865)tcC>tcT	p.S955S		NM_000448.2	NP_000439.1	P15918	RAG1_HUMAN	recombination activating gene 1	955					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				GGGATGGCTCCATTGGGGCAT	0.443000									Familial Hemophagocytic Lymphohistiocytosis				11	31					0	0	1	0	0
RBM47	54502	broad.mit.edu	37	4	40439985	40439985	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:40439985G>A	ENST00000319592.4	-	4	1635	c.926C>T	c.(925-927)tCg>tTg	p.S309L	RBM47_ENST00000295971.7_Missense_Mutation_p.S309L|RBM47_ENST00000514014.1_Missense_Mutation_p.S271L|RBM47_ENST00000381793.2_Missense_Mutation_p.S309L|RBM47_ENST00000515809.1_Intron|RBM47_ENST00000381795.6_Missense_Mutation_p.S309L			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	309	RRM 3.					nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						CTCCAGGCACGAGCCCTCCAG	0.662000													16	39					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155792082	155792082	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:155792082G>A	ENST00000437809.1	-	4	1005	c.883C>T	c.(883-885)Ctt>Ttt	p.L295F	GON4L_ENST00000368331.1_Missense_Mutation_p.L295F|GON4L_ENST00000271883.5_Missense_Mutation_p.L295F|GON4L_ENST00000361040.5_Missense_Mutation_p.L295F|GON4L_ENST00000471341.1_5'UTR			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	295					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					CTCACATGAAGGATGTTTCGG	0.428000													23	127					0	0	1	0	0
BCL9L	283149	broad.mit.edu	37	11	118771541	118771541	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:118771541C>T	ENST00000334801.3	-	6	3875	c.2911G>A	c.(2911-2913)Gga>Aga	p.G971R	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	971	Pro-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		TTGAGAGGTCCTGGCGGGTTG	0.642000													52	35					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25427444	25427444	+	RNA	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr15:25427444C>T	ENST00000424208.1	+	0	241					NR_003305.1																						TCGGGCCCTTCCTGGTGCCCT	0.622000													36	6					0	0	1	0	0
MSRB3	253827	broad.mit.edu	37	12	65856974	65856974	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:65856974C>T	ENST00000308259.5	+	7	704	c.430C>T	c.(430-432)Cgt>Tgt	p.R144C	MSRB3_ENST00000355192.3_Missense_Mutation_p.R151C|MSRB3_ENST00000535664.1_Missense_Mutation_p.R144C	NM_001031679.2|NM_001193460.1	NP_001026849.1|NP_001180389.1	Q8IXL7	MSRB3_HUMAN	methionine sulfoxide reductase B3	151					protein repair	endoplasmic reticulum|mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)	13			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.131)		TGATGGGCCTCGTCCAACTGG	0.517000													57	41					0	0	1	0	0
BRIP1	83990	broad.mit.edu	37	17	59886056	59886056	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:59886056C>T	ENST00000259008.2	-	7	957	c.690G>A	c.(688-690)tcG>tcA	p.S230S	BRIP1_ENST00000577598.1_Silent_p.S230S	NM_032043.2	NP_114432.2	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	230	Helicase ATP-binding.				DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			NS(1)|breast(3)|endometrium(9)|kidney(5)|large_intestine(9)|liver(2)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	55						TAATGGTATTCGATGACTCTT	0.408000			"""F, N, Mis"""			"""AML, leukemia, breast"""		Involved in tolerance or repair of DNA crosslinks					31	6					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75039077	75039077	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:75039077C>T	ENST00000326665.5	-	14	2535	c.2317G>A	c.(2317-2319)Gaa>Aaa	p.E773K	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	773	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TCCATTGCTTCTTTCTTCTCC	0.473000													97	35					0	0	1	0	0
CD300LF	146722	broad.mit.edu	37	17	72699273	72699273	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:72699273G>A	ENST00000361254.4	-	3	400	c.401C>T	c.(400-402)cCt>cTt	p.P134L	CD300LF_ENST00000464910.1_Intron|RAB37_ENST00000340415.3_Intron|RAB37_ENST00000402449.4_Intron|CD300LF_ENST00000326165.6_Intron|CD300LF_ENST00000343125.4_Intron|CD300LF_ENST00000301573.9_Intron|CD300LF_ENST00000583937.1_Missense_Mutation_p.P131L|CD300LF_ENST00000469092.1_Intron|CD300LF_ENST00000581500.1_Missense_Mutation_p.P134L			Q8TDQ1	CLM1_HUMAN	CD300 molecule-like family member f	127						integral to membrane|plasma membrane	receptor activity			endometrium(2)|large_intestine(1)|lung(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						GGTGGGGGCAGGAGTCGACGC	0.592000													28	4					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109475607	109475607	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:109475607C>T	ENST00000356711.2	+	9	1138	c.1012C>T	c.(1012-1014)Ccc>Tcc	p.P338S	MYO16_ENST00000357550.2_Missense_Mutation_p.P338S|MYO16_ENST00000251041.5_Missense_Mutation_p.P338S	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	338					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity	p.P338T(1)		NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TCACGATCTTCCCGTACTGTC	0.433000													52	43					0	0	1	0	0
GYPE	2996	broad.mit.edu	37	4	144826626	144826626	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:144826626G>A	ENST00000358615.4	-	1	86	c.35C>T	c.(34-36)tCa>tTa	p.S12L	GYPE_ENST00000437468.2_Missense_Mutation_p.S12L	NM_198682.2	NP_941391.2	P15421	GLPE_HUMAN	glycophorin E (MNS blood group)	12						integral to plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5	all_hematologic(180;0.158)					TCACTTACCTGACAATAGTAA	0.323000													5	20					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186545032	186545032	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:186545032G>A	ENST00000431808.1	-	14	2102	c.1539C>T	c.(1537-1539)ttC>ttT	p.F513F	SORBS2_ENST00000355634.5_Silent_p.F613F|SORBS2_ENST00000448662.2_Intron|SORBS2_ENST00000284776.7_Silent_p.F513F|SORBS2_ENST00000319471.9_Intron|SORBS2_ENST00000418609.1_Silent_p.F417F|SORBS2_ENST00000449407.2_Intron|SORBS2_ENST00000498125.1_Intron|SORBS2_ENST00000393528.3_Intron|SORBS2_ENST00000437304.2_Intron			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	513						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		TCAGCTTTTCGAATTCGGAGA	0.572000													42	31					0	0	1	0	0
PSD	5662	broad.mit.edu	37	10	104173588	104173588	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:104173588C>T	ENST00000020673.5	-	5	2017	c.1491G>A	c.(1489-1491)agG>agA	p.R497R	PSD_ENST00000406432.1_Silent_p.R497R	NM_001270966.1|NM_002779.3	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	497					regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		TAGGGGGCTCCCTCCCTGGGG	0.622000													31	14					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182296	140182296	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:140182296C>T	ENST00000522353.2	+	1	1514	c.1514C>T	c.(1513-1515)tCg>tTg	p.S505L	PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000532566.2_Missense_Mutation_p.S505L|PCDHA2_ENST00000520672.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCGCGCTGTCGAGCTACGTG	0.682000													69	17					0	0	1	0	0
WDR27	253769	broad.mit.edu	37	6	170072375	170072375	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:170072375C>T	ENST00000333572.6	-	3	826	c.307G>A	c.(307-309)Gaa>Aaa	p.E103K	WDR27_ENST00000420344.2_Missense_Mutation_p.E103K|WDR27_ENST00000423258.1_Missense_Mutation_p.E103K|WDR27_ENST00000448612.1_Missense_Mutation_p.E103K			A2RRH5	WDR27_HUMAN	WD repeat domain 27	103										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)|skin(1)	12		Breast(66;1.53e-05)|Ovarian(120;0.216)		OV - Ovarian serous cystadenocarcinoma(33;6.48e-20)|BRCA - Breast invasive adenocarcinoma(81;3.56e-07)|GBM - Glioblastoma multiforme(31;0.00168)		TCTCTACATTCATCCAGGTTC	0.363000													4	13					0	0	1	0	0
TRAPPC10	7109	broad.mit.edu	37	21	45503144	45503144	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr21:45503144C>T	ENST00000291574.4	+	14	2374	c.2199C>T	c.(2197-2199)acC>acT	p.T733T		NM_003274.4	NP_003265.3	P48553	TPC10_HUMAN	trafficking protein particle complex 10	733					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(4)	41						GCCACGTGACCCTGGAACCAG	0.572000													43	60					0	0	1	0	0
GPR137C	283554	broad.mit.edu	37	14	53066870	53066870	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:53066870C>T	ENST00000321662.6	+	3	528	c.528C>T	c.(526-528)ctC>ctT	p.L176L		NM_001099652.1	NP_001093122.1	Q8N3F9	G137C_HUMAN	G protein-coupled receptor 137C	176						integral to membrane				NS(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	8	Breast(41;0.0716)					CAAGCCTGCTCTTTTTAGTGG	0.333000													41	36					0	0	1	0	0
SLC46A3	283537	broad.mit.edu	37	13	29287434	29287434	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:29287434C>T	ENST00000266943.6	-	3	812	c.443G>A	c.(442-444)tGg>tAg	p.W148*	SLC46A3_ENST00000380814.4_Nonsense_Mutation_p.W148*	NM_001135919.1|NM_181785.3	NP_001129391.1|NP_861450.1	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3	148					transmembrane transport	integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(2)|prostate(1)|skin(1)	15		Lung SC(185;0.0367)		all cancers(112;0.159)		GCAAGCTCCCCAAAATGTGGT	0.378000													24	19					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14773987	14773987	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:14773987C>T	ENST00000261170.3	-	23	2901	c.2765G>A	c.(2764-2766)gGa>gAa	p.G922E		NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	922	Guanylate cyclase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						AGAGTGAACTCCAATGCGAAT	0.458000													6	21					0	0	1	0	0
BAZ1B	9031	broad.mit.edu	37	7	72891688	72891688	+	Silent	SNP	A	A	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:72891688A>C	ENST00000339594.4	-	7	2441	c.2103T>G	c.(2101-2103)gtT>gtG	p.V701V	BAZ1B_ENST00000404251.1_Silent_p.V701V	NM_032408.3	NP_115784.1	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	701					ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(5)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Lung NSC(55;0.0659)|all_lung(88;0.152)				TTTCCTCCTGAACATCAGATC	0.473000													28	29					0	0	1	0	0
STARD6	147323	broad.mit.edu	37	18	51863496	51863496	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr18:51863496G>A	ENST00000581310.1	-	6	639	c.267_splice	c.e6+1	p.S89_splice	STARD6_ENST00000307844.3_Splice_Site_p.S89_splice|STARD6_ENST00000580990.2_5'UTR			P59095	STAR6_HUMAN	StAR-related lipid transfer (START) domain containing 6	89	START.				lipid transport		lipid binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)	8				Colorectal(16;0.021)|READ - Rectum adenocarcinoma(59;0.188)		ACAAATTACCGAATCAATCCT	0.308000													23	28					0	0	1	0	0
VOPP1	81552	broad.mit.edu	37	7	55540610	55540610	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:55540610G>A	ENST00000285279.5	-	5	657	c.457C>T	c.(457-459)Ccc>Tcc	p.P153S	VOPP1_ENST00000427700.1_Missense_Mutation_p.P151S|VOPP1_ENST00000453256.1_Missense_Mutation_p.P86S|VOPP1_ENST00000418904.1_Missense_Mutation_p.P136S|VOPP1_ENST00000545390.1_Missense_Mutation_p.P150S|VOPP1_ENST00000454227.1_Missense_Mutation_p.P90S|VOPP1_ENST00000433959.1_Missense_Mutation_p.P144S|VOPP1_ENST00000428648.1_Missense_Mutation_p.P86S|VOPP1_ENST00000428097.1_Missense_Mutation_p.P86S	NM_030796.3	NP_110423.3	Q96AW1	VOPP1_HUMAN	vesicular, overexpressed in cancer, prosurvival protein 1	153	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic vesicle membrane|endosome|integral to organelle membrane	signal transducer activity			endometrium(1)|lung(4)	5						GCTGGAGGGGGCGGGCAGGCC	0.647000													3	6					0	0	1	0	0
CTR9	9646	broad.mit.edu	37	11	10776721	10776721	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:10776721G>A	ENST00000361367.2	+	3	787	c.361G>A	c.(361-363)Gat>Aat	p.D121N		NM_014633.3	NP_055448.1	Q6PD62	CTR9_HUMAN	CTR9, Paf1/RNA polymerase II complex component	121					histone H2B ubiquitination|histone monoubiquitination	Cdc73/Paf1 complex|nuclear speck				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|pancreas(1)|stomach(1)	40				all cancers(16;1.64e-07)|Epithelial(150;2.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		TACAATGGCCGATAAAATTAT	0.338000													14	61					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150928991	150928991	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:150928991G>A	ENST00000261800.5	-	8	4666	c.4654C>T	c.(4654-4656)Cca>Tca	p.P1552S		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	1552	Cadherin 13.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAGCGGGGTGGGTGGAGGTTT	0.572000													12	3					0	0	1	0	0
SFMBT1	51460	broad.mit.edu	37	3	52950199	52950199	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:52950199G>A	ENST00000394752.3	-	14	1829	c.1447C>T	c.(1447-1449)Ctg>Ttg	p.L483L	SFMBT1_ENST00000358080.2_Silent_p.L483L|SFMBT1_ENST00000394750.1_Silent_p.L483L|SFMBT1_ENST00000296295.6_Silent_p.L483L	NM_016329.3	NP_057413.2	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	483					regulation of transcription, DNA-dependent	nucleus				breast(2)|endometrium(3)|kidney(3)|large_intestine(8)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	24				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		TGATTCCTCAGGCCCTCGTGG	0.398000													7	32					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143094279	143094279	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:143094279C>A	ENST00000367603.2	-	5	2339	c.1597G>T	c.(1597-1599)Gct>Tct	p.A533S	HIVEP2_ENST00000367604.1_Missense_Mutation_p.A533S|HIVEP2_ENST00000012134.2_Missense_Mutation_p.A533S	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	533					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		TCTACAGGAGCTTCTAAGAGA	0.438000													9	42					0.000274275	0.000275197	1	1	0
NLRP10	338322	broad.mit.edu	37	11	7982099	7982099	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:7982099G>A	ENST00000328600.2	-	2	1221	c.1060C>T	c.(1060-1062)Cca>Tca	p.P354S		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	354	NACHT.						ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CAAATGCCTGGAACCTGACAC	0.507000													29	22					0	0	1	0	0
ASTL	431705	broad.mit.edu	37	2	96789684	96789684	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:96789684C>T	ENST00000342380.2	-	9	1200	c.1201G>A	c.(1201-1203)Gaa>Aaa	p.E401K		NM_001002036.3	NP_001002036.3	Q6HA08	ASTL_HUMAN	astacin-like metallo-endopeptidase (M12 family)	401					proteolysis		metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|prostate(1)|skin(2)	30						ATTCCTGCTTCTGAAGATGGG	0.592000													14	62					0	0	1	0	0
ATP1B1	481	broad.mit.edu	37	1	169080704	169080704	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:169080704A>G	ENST00000367816.1	+	3	723	c.194A>G	c.(193-195)aAg>aGg	p.K65R	ATP1B1_ENST00000367813.3_Missense_Mutation_p.K57R|ATP1B1_ENST00000494797.1_3'UTR|ATP1B1_ENST00000367815.3_Missense_Mutation_p.K65R|ATP1B1_ENST00000499679.3_Missense_Mutation_p.K9R			P05026	AT1B1_HUMAN	ATPase, Na+/K+ transporting, beta 1 polypeptide	65					ATP biosynthetic process|blood coagulation|leukocyte migration	sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	14	all_hematologic(923;0.208)					AGTGAATTTAAGCCCACATAT	0.443000													69	26					0	0	1	0	0
SLC2A13	114134	broad.mit.edu	37	12	40345070	40345070	+	Silent	SNP	A	A	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:40345070A>T	ENST00000280871.4	-	4	1073	c.1023T>A	c.(1021-1023)atT>atA	p.I341I	SLC2A13_ENST00000380858.1_Silent_p.I341I	NM_052885.3	NP_443117.3	Q96QE2	MYCT_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 13	341						integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	29		Lung NSC(34;0.105)|all_lung(34;0.123)				TGATGGTGTTAATGCCTGAGA	0.388000										HNSCC(50;0.14)			12	13					0	0	1	0	0
NAT10	55226	broad.mit.edu	37	11	34152949	34152949	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:34152949C>T	ENST00000257829.3	+	14	1597	c.1391C>T	c.(1390-1392)tCc>tTc	p.S464F	NAT10_ENST00000527971.1_Intron|NAT10_ENST00000531159.2_Missense_Mutation_p.S392F	NM_024662.2	NP_078938.2	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 (GCN5-related)	464						nucleolus	ATP binding|N-acetyltransferase activity|protein binding			endometrium(4)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				TATGAGGTTTCCCTCCAGGAG	0.458000													16	40					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179616229	179616229	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:179616229A>G	ENST00000360870.5	-	46	11120	c.10898T>C	c.(10897-10899)gTt>gCt	p.V3633A	TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000590773.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9482	Ig-like 22.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTCAGGTCAACCTTTATCCT	0.378000													88	48					0	0	1	0	0
AOX1	316	broad.mit.edu	37	2	201477399	201477399	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:201477399G>A	ENST00000374700.2	+	14	1572	c.1331G>A	c.(1330-1332)gGa>gAa	p.G444E	AOX1_ENST00000485106.1_3'UTR	NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	444					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	GTCAATTCAGGAATGAGAGTC	0.468000													19	69					0	0	1	0	0
PLCZ1	89869	broad.mit.edu	37	12	18852825	18852825	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:18852825C>T	ENST00000447925.2	-	10	1340	c.1071G>A	c.(1069-1071)gaG>gaA	p.E357E	PLCZ1_ENST00000266505.7_Silent_p.E359E|PLCZ1_ENST00000541695.1_Silent_p.E222E|PLCZ1_ENST00000539875.1_Silent_p.E166E|PLCZ1_ENST00000542762.1_5'UTR|PLCZ1_ENST00000538330.1_Silent_p.E141E|PLCZ1_ENST00000435379.1_Silent_p.E164E	NM_033123.2	NP_149114.2	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	359	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					TTTTGAATTTCTCAGCTTTCG	0.313000													6	8					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	79971513	79971513	+	Splice_Site	SNP	G	G	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:79971513G>T	ENST00000466387.1	+	7	827	c.102_splice	c.e7-1	p.V35_splice	CTNNA2_ENST00000540488.1_Splice_Site_p.V35_splice|CTNNA2_ENST00000361291.4_Splice_Site_p.V69_splice|CTNNA2_ENST00000541047.1_Splice_Site_p.V35_splice|CTNNA2_ENST00000496558.1_Splice_Site_p.V35_splice|CTNNA2_ENST00000402739.4_Splice_Site_p.V35_splice			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	35					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						TATATTTAAGGTGACTACACT	0.373000													25	19					2.79863e-10	2.83182e-10	1	1	0
DPYS	1807	broad.mit.edu	37	8	105405119	105405119	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:105405119C>T	ENST00000351513.2	-	8	1468	c.1336G>A	c.(1336-1338)Gtg>Atg	p.V446M	DPYS_ENST00000521601.1_Intron	NM_001385.2	NP_001376.1	Q14117	DPYS_HUMAN	dihydropyrimidinase	446					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TCATATACCACTTTGCCTCTT	0.443000													79	81					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121787096	121787096	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:121787096G>A	ENST00000261367.7	+	12	4123	c.2695G>A	c.(2695-2697)Gaa>Aaa	p.E899K	SNCAIP_ENST00000542191.1_Missense_Mutation_p.E410K|SNCAIP_ENST00000504884.2_3'UTR|CTC-210G5.1_ENST00000509993.1_RNA|SNCAIP_ENST00000379533.2_Missense_Mutation_p.E899K|SNCAIP_ENST00000261368.8_Missense_Mutation_p.E852K|CTC-210G5.1_ENST00000505546.1_RNA|SNCAIP_ENST00000379536.2_Missense_Mutation_p.E792K|CTC-210G5.1_ENST00000510972.1_RNA|CTC-210G5.1_ENST00000503529.1_RNA|CTC-210G5.1_ENST00000506053.1_RNA|SNCAIP_ENST00000379538.3_Missense_Mutation_p.E486K|SNCAIP_ENST00000503116.2_3'UTR|SNCAIP_ENST00000414317.2_Missense_Mutation_p.E454K			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	852					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		CACAAGTAACGAATCGGGGGA	0.478000													27	12					0	0	1	0	0
HSD17B2	3294	broad.mit.edu	37	16	82124623	82124623	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:82124623C>T	ENST00000199936.4	+	4	974	c.781C>T	c.(781-783)Caa>Taa	p.Q261*	RP11-510J16.5_ENST00000567021.1_RNA	NM_002153.2	NP_002144.1	P37059	DHB2_HUMAN	hydroxysteroid (17-beta) dehydrogenase 2	261					response to retinoic acid|steroid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|binding|estradiol 17-beta-dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	10					NADH(DB00157)	TGCTTCCATCCAACCTGGAGG	0.498000													22	50					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	147743680	147743680	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:147743680G>A	ENST00000370460.2	+	3	911	c.432G>A	c.(430-432)ctG>ctA	p.L144L	AFF2_ENST00000370457.5_Silent_p.L140L|AFF2_ENST00000370458.1_Silent_p.L140L|AFF2_ENST00000342251.3_Silent_p.L140L	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	144					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					TTGTGATACTGAATTCAACTC	0.443000													163	21					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107938070	107938070	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:107938070C>T	ENST00000328300.6	+	51	4984	c.4740C>T	c.(4738-4740)atC>atT	p.I1580I	COL4A5_ENST00000361603.2_Silent_p.I1574I	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	1574	Collagen IV NC1.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						CTGTGGTGATCGCAGTTCACA	0.453000									Alport syndrome with Diffuse Leiomyomatosis				36	3					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155237102	155237102	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:155237102C>T	ENST00000357232.3	-	15	3692	c.3693G>A	c.(3691-3693)atG>atA	p.M1231I		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	1231	Cadherin 10.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GCTGAGTTTTCATTTCATAAT	0.378000													15	11					0	0	1	0	0
DOCK9	23348	broad.mit.edu	37	13	99515695	99515695	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:99515695G>A	ENST00000376460.1	-	31	3474	c.3394C>T	c.(3394-3396)Cgt>Tgt	p.R1132C	DOCK9_ENST00000339416.2_Missense_Mutation_p.R1133C|DOCK9_ENST00000461998.1_5'UTR|DOCK9_ENST00000448493.2_Missense_Mutation_p.R1144C|DOCK9_ENST00000442173.1_Missense_Mutation_p.R1132C	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	1133					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GCGATCAGACGGACCTCCCGG	0.507000													16	53					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112608237	112608237	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:112608237C>T	ENST00000550722.1	-	69	11909	c.11514G>A	c.(11512-11514)acG>acA	p.T3838T	HECTD4_ENST00000430131.2_Silent_p.T3562T|HECTD4_ENST00000377560.5_Silent_p.T3812T	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		CGGTCACCTTCGTGTCATAGA	0.587000											OREG0022132	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	26					0	0	1	0	0
GRIK4	2900	broad.mit.edu	37	11	120732707	120732707	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:120732707C>T	ENST00000527524.2	+	9	1071	c.784C>T	c.(784-786)Cgt>Tgt	p.R262C	GRIK4_ENST00000438375.2_Missense_Mutation_p.R262C|GRIK4_ENST00000527130.1_3'UTR			Q16099	GRIK4_HUMAN	glutamate receptor, ionotropic, kainate 4	262					glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(20)|liver(1)|lung(29)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	69		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	TGTGGATGATCGTGTCAACAT	0.483000													95	78					0	0	1	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58549280	58549280	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:58549280C>T	ENST00000282326.1	+	3	323	c.76C>T	c.(76-78)Cct>Tct	p.P26S	ZSCAN1_ENST00000601162.1_Missense_Mutation_p.P26S|ZSCAN1_ENST00000391700.1_Missense_Mutation_p.P26S	NM_182572.3	NP_872378.3	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	26					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GGACGCAGACCCTGGGCCAGC	0.697000													4	7					0	0	1	0	0
MDH1	4190	broad.mit.edu	37	2	63833147	63833147	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:63833147C>T	ENST00000233114.8	+	8	1299	c.864C>T	c.(862-864)ttC>ttT	p.F288F	MDH1_ENST00000394423.1_Silent_p.F288F|MDH1_ENST00000409908.1_Silent_p.F123F|MDH1_ENST00000409476.1_Silent_p.F164F|MDH1_ENST00000544381.1_Silent_p.F199F|MDH1_ENST00000539945.1_Silent_p.F306F	NM_005917.3	NP_005908.1	P40925	MDHC_HUMAN	malate dehydrogenase 1, NAD (soluble)	288					gluconeogenesis|tricarboxylic acid cycle	centrosome|cytosol	L-malate dehydrogenase activity|malic enzyme activity			endometrium(2)|kidney(4)|large_intestine(1)|liver(2)|lung(4)	13					NADH(DB00157)	TCTACTCATTCCCTGTTGTAA	0.398000													76	44					0	0	1	0	0
ZNF780B	163131	broad.mit.edu	37	19	40540276	40540276	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:40540276G>A	ENST00000434248.1	-	5	2555	c.2490C>T	c.(2488-2490)ttC>ttT	p.F830F	ZNF780B_ENST00000221355.6_Silent_p.F682F	NM_001005851.2	NP_001005851.1	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	830					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					ACCCAAGTATGAATTTTCTGA	0.378000													9	19					0	0	1	0	0
TNS1	7145	broad.mit.edu	37	2	218674599	218674599	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:218674599G>A	ENST00000171887.4	-	30	5360	c.4908C>T	c.(4906-4908)atC>atT	p.I1636I	TNS1_ENST00000419504.1_Silent_p.I1622I|TNS1_ENST00000430930.1_Silent_p.I1615I	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	1636						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TGAAGTGAACGATGGTGGCAG	0.562000													5	29					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17073359	17073359	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:17073359C>T	ENST00000359963.3	-	1	341	c.82G>A	c.(82-84)Gag>Aag	p.E28K		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	28					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GGCTCCTCCTCTTCTGGACTC	0.657000													31	47					0	0	1	0	0
ZIC1	7545	broad.mit.edu	37	3	147130318	147130318	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:147130318C>T	ENST00000282928.4	+	2	1725	c.996C>T	c.(994-996)ttC>ttT	p.F332F		NM_003412.3	NP_003403.2	Q15915	ZIC1_HUMAN	Zic family member 1	332					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(4)|cervix(1)|endometrium(2)|large_intestine(8)|lung(38)|ovary(1)|prostate(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	63						AGAAGCCCTTCAAGTGCGAGT	0.473000													11	37					0	0	1	0	0
TP53I11	9537	broad.mit.edu	37	11	44959125	44959125	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:44959125G>A	ENST00000533940.1	-	6	773	c.169C>T	c.(169-171)Cgg>Tgg	p.R57W	TP53I11_ENST00000308212.5_Missense_Mutation_p.R57W|TP53I11_ENST00000395648.3_Missense_Mutation_p.R57W|TP53I11_ENST00000525680.1_Missense_Mutation_p.R57W|TP53I11_ENST00000531928.2_Missense_Mutation_p.R57W|TP53I11_ENST00000531130.2_5'UTR	NM_001258320.1	NP_001245249.1	O14683	P5I11_HUMAN	tumor protein p53 inducible protein 11	57					negative regulation of cell proliferation|response to stress	integral to membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|ovary(1)	5						AAAGGCTCCCGAATGGTAAAC	0.582000													6	14					0	0	1	0	0
HOXA5	3202	broad.mit.edu	37	7	27181462	27181462	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:27181462G>A	ENST00000222726.3	-	2	865	c.805C>T	c.(805-807)Cgt>Tgt	p.R269C	HOXA-AS3_ENST00000518848.1_RNA|HOXA-AS3_ENST00000521197.1_RNA|HOXA5_ENST00000520854.1_5'UTR|HOXA3_ENST00000467897.2_Intron	NM_019102.3	NP_061975.2	P20719	HXA5_HUMAN	homeobox A5	269					negative regulation of angiogenesis|negative regulation of erythrocyte differentiation|positive regulation of apoptosis|positive regulation of myeloid cell differentiation|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(2)|lung(12)|skin(1)	16						ACTCAGGGACGGAAGGCCCCT	0.468000											OREG0017911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	25					0	0	1	0	0
ZNF786	136051	broad.mit.edu	37	7	148768477	148768477	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:148768477G>A	ENST00000316286.9	-	3	1401	c.1129C>T	c.(1129-1131)Cgt>Tgt	p.R377C	ZNF786_ENST00000451334.3_Missense_Mutation_p.R426C|ZNF786_ENST00000491431.1_Missense_Mutation_p.R463C			Q8N393	ZN786_HUMAN	zinc finger protein 786	463					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|cervix(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(2)	26	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CCCCTCTGACGGAAGTTCCTG	0.612000													5	22					0	0	1	0	0
CEACAM18	729767	broad.mit.edu	37	19	51986412	51986412	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:51986412C>T	ENST00000396477.4	+	4	836	c.815C>T	c.(814-816)tCc>tTc	p.S272F	CEACAM18_ENST00000451626.1_Missense_Mutation_p.S333F	NM_001278392.1	NP_001265321.1	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 18	333						integral to membrane				breast(1)|endometrium(4)|large_intestine(3)|lung(8)|skin(1)	17		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CACAATGGCTCCCTCCTGAAC	0.527000													38	81					0	0	1	0	0
SPATA18	132671	broad.mit.edu	37	4	52943099	52943099	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:52943099C>T	ENST00000295213.4	+	7	1287	c.913C>T	c.(913-915)Cgg>Tgg	p.R305W	SPATA18_ENST00000419395.2_Missense_Mutation_p.R273W	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	305	Ser-rich.				mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			CCTCTTGTCCCGGTTCAGCGA	0.637000													20	11					0	0	1	0	0
CCDC85A	114800	broad.mit.edu	37	2	56611435	56611435	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:56611435C>T	ENST00000407595.2	+	6	2109	c.1607C>T	c.(1606-1608)tCg>tTg	p.S536L	RP11-482H16.1_ENST00000607540.1_RNA	NM_001080433.1	NP_001073902.1	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	536										breast(6)|cervix(2)|endometrium(5)|kidney(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)	38			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GCTGCAGGTTCGTGTCCTGGA	0.408000													26	11					0	0	1	0	0
OR4K1	79544	broad.mit.edu	37	14	20404336	20404336	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:20404336C>T	ENST00000285600.4	+	1	570	c.511C>T	c.(511-513)Ccc>Tcc	p.P171S		NM_001004063.2	NP_001004063.2	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K, member 1	171					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P171S(1)		central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		ATTCTGTGGTCCCAATGAGGT	0.478000													55	62					0	0	1	0	0
ARMC4P1	101060171	broad.mit.edu	37	10	27551988	27551988	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:27551988G>A	ENST00000576034.1	+	0	244																											TGGAATCCTCGAAATCACCCC	0.448000													11	4					0	0	1	0	0
TSC1	7248	broad.mit.edu	37	9	135781444	135781444	+	Silent	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:135781444A>G	ENST00000298552.3	-	15	1742	c.1521T>C	c.(1519-1521)ttT>ttC	p.F507F	TSC1_ENST00000545250.1_Silent_p.F456F|TSC1_ENST00000440111.2_Silent_p.F507F	NM_000368.4|NM_001162426.1|NM_001162427.1	NP_000359.1|NP_001155898.1|NP_001155899.1	Q92574	TSC1_HUMAN	tuberous sclerosis 1	507					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		NS(1)|bone(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(9)|lung(20)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	65				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		TGTCTCGGTAAAAGGGAGAGT	0.562000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				7	16					0	0	1	0	0
COL26A1	136227	broad.mit.edu	37	7	101192473	101192473	+	RNA	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:101192473C>T	ENST00000313669.7	+	0	1154				COL26A1_ENST00000528707.1_RNA|COL26A1_ENST00000397927.3_RNA	NM_133457.2	NP_597714.2			collagen, type XXVI, alpha 1																		CCTCGAGGTCCCCCAGGACCC	0.667000													17	23					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201016683	201016683	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:201016683G>T	ENST00000362061.3	-	37	4739	c.4513C>A	c.(4513-4515)Ctc>Atc	p.L1505I	CACNA1S_ENST00000367338.3_Missense_Mutation_p.L1486I	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	1505					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TGGTCCAAGAGCTTCATGCTG	0.537000													14	60					2.32078e-09	2.34565e-09	1	1	0
POU2F3	25833	broad.mit.edu	37	11	120175767	120175767	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:120175767C>T	ENST00000260264.4	+	7	513	c.479C>T	c.(478-480)tCc>tTc	p.S160F	POU2F3_ENST00000543440.2_Missense_Mutation_p.S158F	NM_001244682.1	NP_001231611.1	Q9UKI9	PO2F3_HUMAN	POU class 2 homeobox 3	158					negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding			large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)	17		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		CTGCCAGGATCCTCTTTAGAA	0.512000													23	24					0	0	1	0	0
ZFP42	132625	broad.mit.edu	37	4	188924022	188924022	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:188924022G>A	ENST00000326866.4	+	4	469	c.61G>A	c.(61-63)Gcc>Acc	p.A21T	ZFP42_ENST00000509524.1_Missense_Mutation_p.A21T	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	21					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		GGGTGGAAGAGCCCCCAGTGG	0.552000													26	35					0	0	1	0	0
RABL5	64792	broad.mit.edu	37	7	100961490	100961490	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:100961490G>A	ENST00000315322.4	-	3	214	c.121C>T	c.(121-123)Cta>Tta	p.L41L	RABL5_ENST00000495166.1_Intron|RABL5_ENST00000498704.2_5'UTR|RABL5_ENST00000517481.1_5'UTR|RABL5_ENST00000437644.2_Intron	NM_022777.2	NP_073614.1	Q9H7X7	RABL5_HUMAN	RAB, member RAS oncogene family-like 5	41							GTP binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	7	Lung NSC(181;0.215)					TCAAATTCTAGGATCCTAAAA	0.507000													89	93					0	0	1	0	0
STK32C	282974	broad.mit.edu	37	10	134021527	134021527	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:134021527G>A	ENST00000368622.1	-	12	1478	c.1097C>T	c.(1096-1098)gCc>gTc	p.A366V	STK32C_ENST00000368625.4_Missense_Mutation_p.A496V			Q86UX6	ST32C_HUMAN	serine/threonine kinase 32C	483							ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|large_intestine(2)|lung(15)|ovary(2)|skin(1)	23		all_cancers(35;2.72e-11)|all_epithelial(44;2.33e-08)|Lung NSC(174;0.000855)|all_lung(145;0.00146)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.112)|Melanoma(40;0.124)|Glioma(114;0.203)		Epithelial(32;3.99e-05)|all cancers(32;5.58e-05)|OV - Ovarian serous cystadenocarcinoma(35;9.96e-05)|BRCA - Breast invasive adenocarcinoma(275;0.222)		GCCGCTCCCGGCCGAGGGGCA	0.711000													12	4					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198725049	198725049	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:198725049C>T	ENST00000367376.2	+	33	3825	c.3654C>T	c.(3652-3654)ttC>ttT	p.F1218F	PTPRC_ENST00000348564.6_Silent_p.F1059F|PTPRC_ENST00000442510.2_Silent_p.F1220F|PTPRC_ENST00000352140.3_Silent_p.F1170F|PTPRC_ENST00000594404.1_Silent_p.F1057F	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1218	Tyrosine-protein phosphatase 2.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						AATATCAATTCCTATATGACG	0.338000													62	14					0	0	1	0	0
ISM2	145501	broad.mit.edu	37	14	77941982	77941982	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:77941982C>T	ENST00000393684.3	-	8	1799	c.1408G>A	c.(1408-1410)Gag>Aag	p.E470K	ISM2_ENST00000493585.1_3'UTR|ISM2_ENST00000342219.4_Missense_Mutation_p.E558K|ISM2_ENST00000429906.1_Missense_Mutation_p.E477K|ISM2_ENST00000412904.1_Missense_Mutation_p.E477K			Q6H9L7	ISM2_HUMAN	isthmin 2	558	AMOP.					extracellular region				endometrium(3)|large_intestine(4)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	21						TACTCCTCCTCCAGGGGGTTG	0.642000													80	50					0	0	1	0	0
ARL6	84100	broad.mit.edu	37	3	97486989	97486989	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:97486989T>C	ENST00000463745.1	+	2	515	c.38T>C	c.(37-39)cTg>cCg	p.L13P	ARL6_ENST00000394206.1_Missense_Mutation_p.L13P|ARL6_ENST00000496713.1_3'UTR|ARL6_ENST00000335979.2_Missense_Mutation_p.L13P	NM_001278293.1	NP_001265222.1	Q9H0F7	ARL6_HUMAN	ADP-ribosylation factor-like 6	13					cilium assembly|determination of left/right symmetry|melanosome transport|protein polymerization|protein targeting to membrane|small GTPase mediated signal transduction|visual perception|Wnt receptor signaling pathway	axonemal microtubule|cilium axoneme|cilium membrane|membrane coat|microtubule basal body	GTP binding|metal ion binding|phospholipid binding|protein binding			large_intestine(1)|lung(4)	5		Lung NSC(201;0.0193)|Prostate(884;0.174)		LUSC - Lung squamous cell carcinoma(29;0.0118)|Lung(72;0.0189)		TTGCTTGGCCTGAAGAAGAAG	0.353000													15	45					0	0	1	0	0
KIAA1804	84451	broad.mit.edu	37	1	233514713	233514713	+	Nonsense_Mutation	SNP	T	T	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:233514713T>A	ENST00000366624.3	+	9	2222	c.1961T>A	c.(1960-1962)tTa>tAa	p.L654*	MLK4_ENST00000366622.1_Nonsense_Mutation_p.L100*	NM_032435.2	NP_115811.2																					CCTGATGGATTAGAACACAGA	0.378000													14	70					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	336826	336826	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:336826C>T	ENST00000343164.4	-	8	892	c.840G>A	c.(838-840)atG>atA	p.M280I	SLC6A13_ENST00000445055.2_Missense_Mutation_p.M188I	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	280					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			TGCCTGCATCCATCCACACCT	0.552000													5	19					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24401909	24401909	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:24401909C>T	ENST00000330966.7	-	22	2923	c.2761G>A	c.(2761-2763)Gaa>Aaa	p.E921K	MYOM3_ENST00000374434.3_Missense_Mutation_p.E920K|MYOM3_ENST00000329601.7_Missense_Mutation_p.E920K|RP11-293P20.4_ENST00000429191.1_RNA|RP11-293P20.2_ENST00000439239.2_RNA			Q5VTT5	MYOM3_HUMAN	myomesin 3	920										NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		TCAGGGGCTTCAAAAGCCAAA	0.517000													78	32					0	0	1	0	0
TAS1R1	80835	broad.mit.edu	37	1	6635392	6635392	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:6635392C>T	ENST00000333172.6	+	3	1393	c.1200C>T	c.(1198-1200)ctC>ctT	p.L400L	TAS1R1_ENST00000351136.3_Intron|TAS1R1_ENST00000328191.4_Silent_p.L400L	NM_138697.3	NP_619642.2	Q7RTX1	TS1R1_HUMAN	taste receptor, type 1, member 1	400					sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(13)|ovary(1)|skin(1)|urinary_tract(2)	29	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		CCCATGGCCTCCACCAGCTCC	0.607000													29	40					0	0	1	0	0
MEGF10	84466	broad.mit.edu	37	5	126776451	126776451	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:126776451G>A	ENST00000274473.6	+	19	2521	c.2254G>A	c.(2254-2256)Gga>Aga	p.G752R	MEGF10_ENST00000503335.2_Missense_Mutation_p.G752R	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	752	EGF-like 14.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup		p.G752*(1)		breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		AGGGTTTTATGGAAAAGATTG	0.512000													33	8					0	0	1	0	0
IGHV1OR21-1	390530	broad.mit.edu	37	21	10862651	10862651	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr21:10862651G>A	ENST00000559480.1	+	0	30																				breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						TCCTGTTTTTGGTGGTCATAG	0.517000													32	335					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	151094937	151094937	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:151094937G>A	ENST00000474524.1	+	28	4220	c.4182G>A	c.(4180-4182)acG>acA	p.T1394T	P2RY12_ENST00000302632.3_Intron|MED12L_ENST00000273432.4_Silent_p.T1254T	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	1394					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CAAGTAGCACGAGACAGAATG	0.368000													16	7					0	0	1	0	0
UGGT2	55757	broad.mit.edu	37	13	96536846	96536846	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:96536846G>A	ENST00000376747.3	-	27	3197	c.3127C>T	c.(3127-3129)Cct>Tct	p.P1043S		NM_020121.3	NP_064506.3	Q9NYU1	UGGG2_HUMAN	UDP-glucose glycoprotein glucosyltransferase 2	1043					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(17)|lung(20)|ovary(3)|pancreas(1)|prostate(4)|urinary_tract(2)	60						GGTGATTCAGGAATATCCAAA	0.408000													28	28					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30701840	30701840	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:30701840G>A	ENST00000256246.2	-	1	4768	c.4694C>T	c.(4693-4695)tCc>tTc	p.S1565F		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1565										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TCCTGGTTTGGAAATATAGGC	0.398000													43	74					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9060263	9060263	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:9060263C>T	ENST00000397910.4	-	3	27386	c.27183G>A	c.(27181-27183)gtG>gtA	p.V9061V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9063	Ser-rich.|Thr-rich.			S -> T (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCCTGGTGATCACTTCAGTGG	0.498000													28	35					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8604862	8604862	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:8604862C>T	ENST00000338257.8	-	16	1928	c.1661G>A	c.(1660-1662)gGg>gAg	p.G554E		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	554	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						GCTGGGGCGCCCCTTCTTGTC	0.642000													8	27					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176845698	176845698	+	Silent	SNP	G	G	A	rs144976382	by1000genomes	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:176845698G>A	ENST00000367654.2	-	21	3475	c.3462C>T	c.(3460-3462)ccC>ccT	p.P1154P	ASTN1_ENST00000361833.2_Silent_p.P1146P|ASTN1_ENST00000367657.3_Silent_p.P1146P|ASTN1_ENST00000424564.2_Silent_p.P1146P			O14525	ASTN1_HUMAN	astrotactin 1	1154					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CATCCACCACGGGGCATGGGG	0.582000													12	88					0	0	1	0	0
PCOLCE2	26577	broad.mit.edu	37	3	142607685	142607685	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:142607685G>A	ENST00000295992.3	-	1	360	c.54C>T	c.(52-54)acC>acT	p.T18T	PCOLCE2_ENST00000485766.1_Silent_p.T18T|PCOLCE2_ENST00000461818.1_5'UTR	NM_013363.3	NP_037495.1	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	18						extracellular region	collagen binding|heparin binding|peptidase activator activity			NS(1)|endometrium(1)|large_intestine(11)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	32						GCGAGAGCTGGGTGGCGGCAG	0.721000													7	6					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80732900	80732900	+	Missense_Mutation	SNP	G	G	A	rs143817729	by1000genomes	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:80732900G>A	ENST00000458043.2	+	42	4885	c.4879G>A	c.(4879-4881)Gaa>Aaa	p.E1627K	OTOGL_ENST00000547103.1_Missense_Mutation_p.E1615K	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TTCAAGTCAGGAACTGTCCAT	0.338000													23	52					0	0	1	0	0
MED8	112950	broad.mit.edu	37	1	43852618	43852618	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:43852618G>A	ENST00000372457.4	-	4	365	c.322C>T	c.(322-324)Cat>Tat	p.H108Y	MED8_ENST00000290663.6_Missense_Mutation_p.H108Y|RP1-92O14.6_ENST00000436713.1_RNA|MED8_ENST00000372455.4_Missense_Mutation_p.H19Y	NM_001001653.2|NM_201542.3	NP_001001653.1|NP_963836.2	Q96G25	MED8_HUMAN	mediator complex subunit 8	108					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				endometrium(2)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	9	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GTTCTCAGATGGTCAGGGACT	0.517000													117	41					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40433642	40433642	+	Silent	SNP	G	G	A	rs138162470	byFrequency	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:40433642G>A	ENST00000221347.6	-	2	634	c.627C>T	c.(625-627)ctC>ctT	p.L209L		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	209	IgGFc-binding.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TTGACCCCGAGAGATCCACTG	0.552000													24	57					0	0	1	0	0
FOXN2	3344	broad.mit.edu	37	2	48573792	48573792	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:48573792C>T	ENST00000340553.3	+	3	700	c.439C>T	c.(439-441)Cca>Tca	p.P147S		NM_002158.3	NP_002149.2	P32314	FOXN2_HUMAN	forkhead box N2	147					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	13		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)			GGACCATTTTCCATATTTTGC	0.393000													120	48					0	0	1	0	0
MC3R	4159	broad.mit.edu	37	20	54824478	54824478	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:54824478C>T	ENST00000243911.2	+	1	691	c.579C>T	c.(577-579)atC>atT	p.I193I		NM_019888.3	NP_063941.3	P41968	MC3R_HUMAN	melanocortin 3 receptor	230					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(3)|skin(1)	26			Colorectal(105;0.202)			TGTGCCTCATCACCATGTTCT	0.577000													92	53					0	0	1	0	0
ABHD3	171586	broad.mit.edu	37	18	19282284	19282284	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr18:19282284C>T	ENST00000289119.2	-	3	641	c.502G>A	c.(502-504)Gga>Aga	p.G168R	ABHD3_ENST00000580981.1_Missense_Mutation_p.G168R|ABHD3_ENST00000579875.1_5'UTR|ABHD3_ENST00000578270.1_5'UTR	NM_138340.4	NP_612213.2	Q8WU67	ABHD3_HUMAN	abhydrolase domain containing 3	168						integral to membrane	carboxylesterase activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(2)|prostate(2)	10						TACCTGTATCCTAATTCTTCA	0.368000													19	34					0	0	1	0	0
KRT81	3887	broad.mit.edu	37	12	52682147	52682147	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:52682147C>T	ENST00000327741.5	-	4	801	c.733G>A	c.(733-735)Gag>Aag	p.E245K	KRT86_ENST00000423955.2_Intron|KRT86_ENST00000544024.1_Intron	NM_002281.3	NP_002272.2	Q14533	KRT81_HUMAN	keratin 81	245	Coil 1B.|Rod.					keratin filament	protein binding|structural molecule activity			breast(2)|endometrium(3)|large_intestine(3)|lung(6)|prostate(1)|stomach(1)	16				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCCCGCACCTCCTCATACAGC	0.612000													39	35					0	0	1	0	0
KIAA1755	85449	broad.mit.edu	37	20	36869200	36869200	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:36869200C>T	ENST00000279024.4	-	3	1604	c.1333G>A	c.(1333-1335)Gag>Aag	p.E445K		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	445										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				CCATTTCTCTCTTTGGTCTTC	0.577000													39	99					0	0	1	0	0
PROC	5624	broad.mit.edu	37	2	128186467	128186467	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:128186467G>A	ENST00000453608.2	+	8	1504	c.1496G>A	c.(1495-1497)tGg>tAg	p.W499*	PROC_ENST00000422777.3_Nonsense_Mutation_p.W444*|PROC_ENST00000234071.3_Nonsense_Mutation_p.W444*|PROC_ENST00000409048.1_Nonsense_Mutation_p.W478*			P04070	PROC_HUMAN	protein C (inactivator of coagulation factors Va and VIIIa)	444					blood coagulation|leukocyte migration|negative regulation of apoptosis|negative regulation of blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|protein binding|serine-type endopeptidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0673)	Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)|Sodium Tetradecyl Sulfate(DB00464)	TACCTCGACTGGATCCATGGG	0.612000													30	155					0	0	1	0	0
FUT10	84750	broad.mit.edu	37	8	33318914	33318914	+	Silent	SNP	G	G	A	rs144713664		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:33318914G>A	ENST00000327671.5	-	2	688	c.57C>T	c.(55-57)acC>acT	p.T19T	FUT10_ENST00000524021.1_Intron|FUT10_ENST00000518672.1_Intron|FUT10_ENST00000335589.3_5'UTR	NM_032664.3	NP_116053.3	Q6P4F1	FUT10_HUMAN	fucosyltransferase 10 (alpha (1,3) fucosyltransferase)	19					embryo development|fertilization|hemopoiesis|L-fucose catabolic process|nervous system development|protein folding|protein glycosylation|protein targeting|wound healing	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			cervix(1)|endometrium(1)|large_intestine(7)|liver(1)|lung(9)|ovary(1)|pancreas(1)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	29				KIRC - Kidney renal clear cell carcinoma(67;0.129)|Kidney(114;0.154)		GCAGAAAGACGGTGGCTGTGA	0.542000													4	63					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166179728	166179728	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:166179728C>T	ENST00000357398.3	+	12	2024	c.1734C>T	c.(1732-1734)ttC>ttT	p.F578F	SCN2A_ENST00000283256.6_Silent_p.F578F|SCN2A_ENST00000375437.2_Silent_p.F578F|SCN2A_ENST00000375427.2_Silent_p.F578F			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	578					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	CGAGCCTTTTCAGCTTCAGAG	0.468000													8	46					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51111250	51111250	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:51111250G>A	ENST00000395542.2	-	10	1666	c.1482C>T	c.(1480-1482)tcC>tcT	p.S494S	COBL_ENST00000265136.7_Silent_p.S412S			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	412										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					TGTCTGAGGGGGAACTCATCA	0.587000													25	31					0	0	1	0	0
TMEM132D	121256	broad.mit.edu	37	12	129694173	129694173	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:129694173C>T	ENST00000422113.2	-	5	1661	c.1335G>A	c.(1333-1335)ggG>ggA	p.G445G	RP11-669N7.3_ENST00000542578.1_lincRNA	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	445						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CCACCGTCTTCCCCGTGAGGA	0.587000													17	25					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18384657	18384657	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:18384657C>T	ENST00000441493.2	-	5	1030	c.678G>A	c.(676-678)agG>agA	p.R226R	MICAL3_ENST00000414725.2_Silent_p.R226R|MICAL3_ENST00000207726.7_Silent_p.R226R|MICAL3_ENST00000400561.2_Silent_p.R226R|MICAL3_ENST00000585038.1_Silent_p.R226R|MICAL3_ENST00000429452.1_Silent_p.R226R|MICAL3_ENST00000383094.3_Silent_p.R226R|MICAL3_ENST00000444520.1_Silent_p.R226R	NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	226						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		CCAAGGTGTTCCTCCGACCAT	0.552000													16	14					0	0	1	0	0
TMPRSS3	64699	broad.mit.edu	37	21	43809080	43809080	+	Missense_Mutation	SNP	C	C	T	rs143762350		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr21:43809080C>T	ENST00000291532.3	-	4	1235	c.280G>A	c.(280-282)Gga>Aga	p.G94R	TMPRSS3_ENST00000398405.1_Missense_Mutation_p.G92R|TMPRSS3_ENST00000380399.1_Missense_Mutation_p.G178R|TMPRSS3_ENST00000398397.3_Missense_Mutation_p.G94R|TMPRSS3_ENST00000474596.1_5'UTR|TMPRSS3_ENST00000433957.2_Missense_Mutation_p.G94R	NM_032404.2	NP_115780.1	P57727	TMPS3_HUMAN	transmembrane protease, serine 3	94	LDL-receptor class A.				cellular sodium ion homeostasis|proteolysis	endoplasmic reticulum membrane|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity|sodium channel regulator activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(4)|skin(1)	13						TCCGAGACTCCGTCACATCGA	0.537000													15	25					0	0	1	0	0
MYSM1	114803	broad.mit.edu	37	1	59147776	59147776	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:59147776G>A	ENST00000472487.1	-	8	979	c.940C>T	c.(940-942)Cag>Tag	p.Q314*	MYSM1_ENST00000493821.1_5'UTR	NM_001085487.2	NP_001078956.1	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	314					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(7;9.36e-06)					TTAAATTTCTGGTCATTTAAT	0.358000													120	39					0	0	1	0	0
DMKN	93099	broad.mit.edu	37	19	36002317	36002317	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:36002317G>A	ENST00000339686.3	-	5	1090	c.914C>T	c.(913-915)tCc>tTc	p.S305F	DMKN_ENST00000429837.1_Intron|DMKN_ENST00000447113.2_Missense_Mutation_p.S305F|DMKN_ENST00000424570.2_Missense_Mutation_p.S305F|DMKN_ENST00000419602.1_Intron|DMKN_ENST00000451297.2_Missense_Mutation_p.S305F|DMKN_ENST00000418261.1_Missense_Mutation_p.S305F|DMKN_ENST00000440396.1_Missense_Mutation_p.S305F	NM_033317.4	NP_201574.3	Q6E0U4	DMKN_HUMAN	dermokine	305	Gly-rich.					extracellular region				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|ovary(1)|prostate(1)|skin(2)	27	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			ACTCACCCAGGAGGACTCACT	0.642000													8	29					0	0	1	0	0
GPN2	54707	broad.mit.edu	37	1	27210669	27210669	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:27210669G>A	ENST00000374135.4	-	4	1042	c.842C>T	c.(841-843)gCc>gTc	p.A281V	GPN2_ENST00000374133.3_Missense_Mutation_p.A102V	NM_018066.3	NP_060536.3	Q9H9Y4	GPN2_HUMAN	GPN-loop GTPase 2	281							GTP binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|urinary_tract(1)	9						ATGGAAGTCGGCTCCCATTGC	0.537000													27	42					0	0	1	0	0
PCDHB10	56126	broad.mit.edu	37	5	140573265	140573265	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:140573265G>A	ENST00000239446.4	+	1	1324	c.1140G>A	c.(1138-1140)aaG>aaA	p.K380K		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		380	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAAATGGAAAGATGGTTTGCT	0.413000													3	20					0	0	1	0	0
ZMYM4	9202	broad.mit.edu	37	1	35873739	35873739	+	Silent	SNP	C	C	T	rs138638219		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:35873739C>T	ENST00000314607.6	+	26	4007	c.3927C>T	c.(3925-3927)taC>taT	p.Y1309Y	ZMYM4_ENST00000373297.2_Silent_p.Y1220Y	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	1309					multicellular organismal development		DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GTATCTTATACTTGTGCCTTG	0.403000													29	61					0	0	1	0	0
MUC3A	4584	broad.mit.edu	37	7	100607746	100607746	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:100607746G>A	ENST00000319509.7	+	5	1893	c.1892_splice	c.e5-1	p.R631_splice	RP11-395B7.2_ENST00000420080.1_RNA|RP11-395B7.2_ENST00000434775.1_RNA					mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						GACCCCTCAGGAATGGCAGCA	0.597000													8	74					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38795982	38795982	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:38795982G>A	ENST00000359357.3	+	28	3709	c.3455G>A	c.(3454-3456)aGa>aAa	p.R1152K	DNAH8_ENST00000449981.2_Missense_Mutation_p.R1369K|DNAH8_ENST00000441566.1_Missense_Mutation_p.R1152K					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						ATTTTAAACAGATTTGAAGTT	0.358000													36	24					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155790414	155790414	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:155790414C>T	ENST00000437809.1	-	6	1119	c.997G>A	c.(997-999)Gta>Ata	p.V333I	GON4L_ENST00000368331.1_Missense_Mutation_p.V333I|GON4L_ENST00000271883.5_Missense_Mutation_p.V333I|GON4L_ENST00000361040.5_Missense_Mutation_p.V333I|GON4L_ENST00000471341.1_5'UTR			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	333					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TTTTCCACTACTTCCTTCAGT	0.368000													16	54					0	0	1	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202306	140202306	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:140202306G>A	ENST00000529859.1	+	1	946	c.946G>A	c.(946-948)Gaa>Aaa	p.E316K	PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Missense_Mutation_p.E316K|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000378126.3_Missense_Mutation_p.E316K|PCDHA1_ENST00000394633.3_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAACTCATATGAAATTAATAT	0.323000													12	11					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:29625877G>A	ENST00000278882.3	+	5	501	c.121G>A	c.(121-123)Gcc>Acc	p.A41T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A41T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A46T														p.A41T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTACAGAATCGCCCTGAAATC	0.358000													7	65					0	0	1	0	0
PDCL3	79031	broad.mit.edu	37	2	101182969	101182969	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:101182969C>T	ENST00000264254.6	+	2	389	c.11C>T	c.(10-12)cCc>cTc	p.P4L		NM_024065.4	NP_076970.1	Q9H2J4	PDCL3_HUMAN	phosducin-like 3	4					apoptosis|interspecies interaction between organisms	cytoplasm	protein binding			endometrium(3)|large_intestine(2)|liver(1)|lung(6)	12						TTCTAGGACCCCAACGCAGAC	0.507000													12	50					0	0	1	0	0
OR8J3	81168	broad.mit.edu	37	11	55905119	55905119	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:55905119G>A	ENST00000301529.1	-	1	75	c.76C>T	c.(76-78)Ccc>Tcc	p.P26S		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	26					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					AGGAAGAGGGGAATCTGGAGC	0.493000													18	53					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179582510	179582510	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:179582510C>T	ENST00000589042.1	-	87	25315	c.25091G>A	c.(25090-25092)aGa>aAa	p.R8364K	TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R8047K|TTN_ENST00000342992.6_Missense_Mutation_p.R7120K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8047	Ig-like 66.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCAGTTTTCTTGCAAAGAA	0.413000													8	27					0	0	1	0	0
CSF2RB	1439	broad.mit.edu	37	22	37334021	37334021	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:37334021G>A	ENST00000262825.5	+	14	2406	c.2189G>A	c.(2188-2190)gGg>gAg	p.G730E	CSF2RB_ENST00000536485.1_Missense_Mutation_p.G671E|CSF2RB_ENST00000406230.1_Missense_Mutation_p.G730E|CSF2RB_ENST00000403662.3_Missense_Mutation_p.G724E	NM_000395.2	NP_000386.1	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	724					respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	CCAAACTCAGGGGCCTCGTCT	0.627000													45	50					0	0	1	0	0
GCG	2641	broad.mit.edu	37	2	163000606	163000606	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:163000606T>C	ENST00000418842.2	-	5	721	c.467A>G	c.(466-468)aAc>aGc	p.N156S	GCG_ENST00000375497.3_Missense_Mutation_p.N156S	NM_002054.4	NP_002045.1	P01275	GLUC_HUMAN	glucagon	156					cell proliferation|cellular response to glucagon stimulus|energy reserve metabolic process|feeding behavior|regulation of insulin secretion	plasma membrane|soluble fraction	hormone activity			breast(1)|central_nervous_system(1)|large_intestine(3)|lung(9)	14					Exenatide(DB01276)|Phentolamine(DB00692)	AAGAATGGTGTTCATCTCATC	0.398000													9	44					0	0	1	0	0
OR1G1	8390	broad.mit.edu	37	17	3029915	3029915	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:3029915G>A	ENST00000328890.2	-	1	960	c.931C>T	c.(931-933)Cat>Tat	p.H311Y		NM_003555.1	NP_003546.1	P47890	OR1G1_HUMAN	olfactory receptor, family 1, subfamily G, member 1	311					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(3)|skin(3)	11						TAAGGGGAATGAATTTTCCGA	0.423000													32	7					0	0	1	0	0
NELFA	7469	broad.mit.edu	37	4	1985646	1985646	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:1985646G>A	ENST00000382882.3	-	9	2381	c.1264C>T	c.(1264-1266)Ccg>Tcg	p.P422S	NELFA_ENST00000411638.1_Missense_Mutation_p.P411S|NELFA_ENST00000542778.1_Missense_Mutation_p.P276S	NM_005663.4	NP_005654.3			negative elongation factor complex member A																		ATGGCAACCGGGGGTGTCTGA	0.682000													24	23					0	0	1	0	0
TRIM55	84675	broad.mit.edu	37	8	67064668	67064668	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:67064668G>A	ENST00000315962.4	+	8	1415	c.1042G>A	c.(1042-1044)Gaa>Aaa	p.E348K	TRIM55_ENST00000350034.4_Intron|TRIM55_ENST00000276573.7_Missense_Mutation_p.E348K|TRIM55_ENST00000353317.5_Missense_Mutation_p.E348K	NM_184085.1	NP_908973.1	Q9BYV6	TRI55_HUMAN	tripartite motif containing 55	348						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	39		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			aggagaaggagaagtgggagg	0.408000													9	13					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119976641	119976641	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:119976641C>T	ENST00000313400.4	-	3	1111	c.1011G>A	c.(1009-1011)aaG>aaA	p.K337K	ASTN2_ENST00000361209.2_Silent_p.K337K|ASTN2_ENST00000373996.3_Silent_p.K337K|ASTN2_ENST00000361477.3_5'UTR			O75129	ASTN2_HUMAN	astrotactin 2	337						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						ACTCACCTTTCTTCTCAAAGT	0.557000													73	58					0	0	1	0	0
RFX4	5992	broad.mit.edu	37	12	106995096	106995096	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:106995096G>A	ENST00000357881.4	+	1	182	c.42G>A	c.(40-42)agG>agA	p.R14R	RP11-144F15.1_ENST00000551505.1_Intron|RFX4_ENST00000392842.1_Intron	NM_001206691.1	NP_001193620.1	Q33E94	RFX4_HUMAN	regulatory factor X, 4 (influences HLA class II expression)	0					transcription, DNA-dependent	nucleus	DNA binding			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(20)|pancreas(1)|upper_aerodigestive_tract(1)	35						GAGGCGACAGGACCAGGCCTC	0.667000													3	1					0	0	1	0	0
TAT	6898	broad.mit.edu	37	16	71609891	71609891	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:71609891C>T	ENST00000355962.4	-	3	407	c.274G>A	c.(274-276)Gaa>Aaa	p.E92K	RP11-432I5.1_ENST00000561529.1_RNA	NM_000353.2	NP_000344.1	P17735	ATTY_HUMAN	tyrosine aminotransferase	92					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(3)	29		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	TGGGTAACTTCAGGGTCTGTA	0.493000													32	33					0	0	1	0	0
OR7A17	26333	broad.mit.edu	37	19	14991802	14991802	+	Silent	SNP	C	C	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:14991802C>G	ENST00000327462.2	-	1	462	c.366G>C	c.(364-366)cgG>cgC	p.R122R		NM_030901.1	NP_112163.1	O14581	OR7AH_HUMAN	olfactory receptor, family 7, subfamily A, member 17	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)	12	Ovarian(108;0.203)					TGGCCACAAACCGATCATAGG	0.507000													16	29					0	0	1	0	0
AASS	10157	broad.mit.edu	37	7	121726102	121726102	+	Silent	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:121726102A>G	ENST00000393376.1	-	18	2243	c.2148T>C	c.(2146-2148)tcT>tcC	p.S716S	AASS_ENST00000473553.1_5'UTR|AASS_ENST00000417368.2_Silent_p.S716S			Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase	716	Saccharopine dehydrogenase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(6)|large_intestine(12)|lung(27)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	54					L-Glutamic Acid(DB00142)|NADH(DB00157)	AAGTGTGAGCAGAAGAAATGC	0.403000													17	17					0	0	1	0	0
VIPR2	7434	broad.mit.edu	37	7	158935212	158935212	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:158935212C>T	ENST00000262178.2	-	2	262	c.77G>A	c.(76-78)cGa>cAa	p.R26Q	VIPR2_ENST00000402066.1_Missense_Mutation_p.R167Q|VIPR2_ENST00000421760.2_Missense_Mutation_p.R26Q	NM_003382.4	NP_003373.2	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2	26					cell-cell signaling	integral to plasma membrane				central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	22	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)		CAGATGAAATCGGCATTCTGG	0.373000													15	71					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13914635	13914635	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:13914635C>T	ENST00000265104.4	-	10	1418	c.1314G>A	c.(1312-1314)ctG>ctA	p.L438L		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	438	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTACCTGTTTCAGTTTAATCG	0.313000									Kartagener syndrome				44	6					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9059611	9059611	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:9059611G>A	ENST00000397910.4	-	3	28038	c.27835C>T	c.(27835-27837)Caa>Taa	p.Q9279*		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9281	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GACTTTGTTTGAATCCTACTG	0.473000													40	33					0	0	1	0	0
DDX24	57062	broad.mit.edu	37	14	94526551	94526551	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:94526551G>A	ENST00000330836.5	-	5	1937	c.1806C>T	c.(1804-1806)cgC>cgT	p.R602R	DDX24_ENST00000555054.1_Silent_p.R559R|DDX24_ENST00000544005.1_Silent_p.R352R	NM_020414.3	NP_065147.1	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 24	602	Helicase C-terminal.				RNA metabolic process	cytoplasm|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			cervix(3)|endometrium(4)|kidney(4)|large_intestine(5)|lung(3)|ovary(2)|skin(1)|urinary_tract(1)	23		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		GCCCAGAGAGGCGTTTGATGC	0.502000													21	46					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7169929	7169929	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:7169929C>T	ENST00000406697.1	+	6	784	c.156C>T	c.(154-156)ctC>ctT	p.L52L	C1S_ENST00000402681.3_Intron|C1S_ENST00000360817.5_Silent_p.L52L|C1S_ENST00000328916.3_Silent_p.L52L			P09871	C1S_HUMAN	complement component 1, s subcomponent	52	CUB 1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	GGATTCACCTCTACTTCACCC	0.463000													10	34					0	0	1	0	0
KPRP	448834	broad.mit.edu	37	1	152732545	152732545	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:152732545C>T	ENST00000368773.1	+	2	539	c.481C>T	c.(481-483)Cct>Tct	p.P161S	KPRP_ENST00000606109.1_Missense_Mutation_p.P161S	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	161	Gln-rich.					cytoplasm				NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCTCCTCAGCCTGTCCAGAT	0.507000													22	136					0	0	1	0	0
SGCZ	137868	broad.mit.edu	37	8	13948115	13948115	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:13948115C>T	ENST00000382080.1	-	8	1491	c.776G>A	c.(775-777)gGa>gAa	p.G259E	SGCZ_ENST00000421524.2_Missense_Mutation_p.G212E	NM_139167.2	NP_631906.2	Q96LD1	SGCZ_HUMAN	sarcoglycan, zeta	246	Poly-Ser.				cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				NS(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(14)|lung(15)|ovary(2)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	47				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		TGGTAGATTTCCCAGCTTGAT	0.403000													24	35					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131520818	131520818	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:131520818C>T	ENST00000423981.1	+	2	1283	c.1173C>T	c.(1171-1173)ttC>ttT	p.F391F	AMER3_ENST00000321420.4_Silent_p.F391F	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		ATGATTCCTTCTCGCCAGGAC	0.622000													46	14					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19451432	19451432	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:19451432C>T	ENST00000396229.2	+	3	821	c.72C>T	c.(70-72)aaC>aaT	p.N24N	TMC5_ENST00000542583.2_Silent_p.N24N|TMC5_ENST00000541464.1_Silent_p.N24N|TMC5_ENST00000381414.4_Silent_p.N24N	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	24						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						GGTCTCAGAACCGTACGCAGG	0.498000													25	38					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100171164	100171164	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:100171164G>A	ENST00000317233.4	-	22	3551	c.3316C>T	c.(3316-3318)Ccg>Tcg	p.P1106S	AFF3_ENST00000409579.1_Missense_Mutation_p.P1131S|AFF3_ENST00000409236.1_Missense_Mutation_p.P1106S|AFF3_ENST00000356421.2_Missense_Mutation_p.P1131S	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	1106					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						GCCCCCCACGGAGATGGGGCT	0.512000													34	10					0	0	1	0	0
ITPKB	3707	broad.mit.edu	37	1	226825421	226825421	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:226825421G>A	ENST00000429204.1	-	7	2911	c.2584C>T	c.(2584-2586)Cga>Tga	p.R862*	ITPKB_ENST00000272117.3_Nonsense_Mutation_p.R862*	NM_002221.3	NP_002212.3	P27987	IP3KB_HUMAN	inositol-trisphosphate 3-kinase B	862							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(1)	30		Prostate(94;0.0773)				AGAGTGGTTCGAATGGCCTTC	0.552000											OREG0014299	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	26					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31422168	31422168	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:31422168G>A	ENST00000389202.2	+	12	1374	c.1325G>A	c.(1324-1326)tGg>tAg	p.W442*		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	442					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						TCCAGGCAATGGAGGAAGAAG	0.652000													30	46					0	0	1	0	0
ZNF300P1	134466	broad.mit.edu	37	5	150310880	150310880	+	RNA	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:150310880C>T	ENST00000520773.1	-	0	2441																											AGAATGCTTTCCCACATTCAG	0.418000													7	4					0	0	1	0	0
IL2RB	3560	broad.mit.edu	37	22	37528437	37528437	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:37528437C>T	ENST00000216223.5	-	9	1088	c.890G>A	c.(889-891)gGa>gAa	p.G297E		NM_000878.3	NP_000869.1	P14784	IL2RB_HUMAN	interleukin 2 receptor, beta	297					interspecies interaction between organisms|positive regulation of survival gene product expression|protein complex assembly	external side of plasma membrane|integral to plasma membrane	interleukin-2 receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(5)	23					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	GACGTCTCCTCCATGCTCTGA	0.582000													19	9					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	31227664	31227664	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:31227664G>A	ENST00000357033.4	-	65	9720	c.9514C>T	c.(9514-9516)Cct>Tct	p.P3172S	DMD_ENST00000361471.4_Missense_Mutation_p.P104S|DMD_ENST00000474231.1_Missense_Mutation_p.P712S|DMD_ENST00000343523.2_Missense_Mutation_p.P712S|DMD_ENST00000541735.1_Missense_Mutation_p.P712S|DMD_ENST00000378707.3_Missense_Mutation_p.P712S|DMD_ENST00000378677.2_Missense_Mutation_p.P3168S|DMD_ENST00000359836.1_Missense_Mutation_p.P712S|DMD_ENST00000378702.4_Missense_Mutation_p.P104S|DMD_ENST00000378723.3_Missense_Mutation_p.P104S|DMD_ENST00000378680.2_Missense_Mutation_p.P104S	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	3172	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ACGCAGAGAGGGACGTTGACC	0.458000													35	7					0	0	1	0	0
OXR1	55074	broad.mit.edu	37	8	107719106	107719106	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:107719106C>T	ENST00000445937.1	+	9	1618	c.1357C>T	c.(1357-1359)Ctt>Ttt	p.L453F	OXR1_ENST00000517566.2_Missense_Mutation_p.L453F|OXR1_ENST00000312046.6_Missense_Mutation_p.L446F|OXR1_ENST00000452423.2_5'UTR|OXR1_ENST00000497705.1_Missense_Mutation_p.L386F|OXR1_ENST00000531443.1_Missense_Mutation_p.L453F|OXR1_ENST00000442977.2_Missense_Mutation_p.L454F	NM_018002.3	NP_060472.2	Q8N573	OXR1_HUMAN	oxidation resistance 1	454					cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion				NS(2)|breast(2)|endometrium(2)|large_intestine(9)|lung(10)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	31			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			GGATTCTTTTCTTCATGAGAA	0.358000													17	34					0	0	1	0	0
PDILT	204474	broad.mit.edu	37	16	20380832	20380832	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:20380832G>A	ENST00000302451.4	-	8	1346	c.1098C>T	c.(1096-1098)ttC>ttT	p.F366F		NM_174924.1	NP_777584.1	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis expressed	366					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(33)|prostate(3)|skin(1)|urinary_tract(1)	61						TTTTACTCAGGAAGCTGCGGC	0.428000													64	81					0	0	1	0	0
MAP3K5	4217	broad.mit.edu	37	6	136923045	136923045	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:136923045A>C	ENST00000359015.4	-	20	3112	c.2752T>G	c.(2752-2754)Tgt>Ggt	p.C918G	MAP3K5_ENST00000355845.4_Missense_Mutation_p.C165G	NM_005923.3	NP_005914.1	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase 5	918	Protein kinase.				activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(6)|large_intestine(6)|lung(24)|ovary(2)|prostate(1)|skin(4)|urinary_tract(4)	58	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		GGTTCAAAACATTTCAGTATG	0.398000													9	28					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23234557	23234557	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:23234557C>T	ENST00000400191.3	+	12	2266	c.2248C>T	c.(2248-2250)Cgc>Tgc	p.R750C	EPHB2_ENST00000374632.3_Missense_Mutation_p.R751C|EPHB2_ENST00000374627.1_Missense_Mutation_p.R745C|EPHB2_ENST00000374630.3_Missense_Mutation_p.R750C	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	750	Protein kinase.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		CCTGGCTGCCCGCAACATCCT	0.572000													18	120					0	0	1	0	0
OR51E2	81285	broad.mit.edu	37	11	4703402	4703402	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:4703402G>A	ENST00000396950.3	-	2	779	c.540C>T	c.(538-540)caC>caT	p.H180H		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	180					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		TTACATCCTGGTGGACACAAT	0.517000													30	32					0	0	1	0	0
KIF13B	23303	broad.mit.edu	37	8	28997622	28997622	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:28997622G>A	ENST00000524189.1	-	21	2609	c.2571C>T	c.(2569-2571)gtC>gtT	p.V857V	CTD-2647L4.1_ENST00000523661.1_RNA|CTD-2647L4.1_ENST00000517632.1_RNA	NM_015254.3	NP_056069.2	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	857					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding			endometrium(6)|kidney(1)|lung(20)|urinary_tract(1)	28		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		TCTCAAAGGAGACCTCTGCCA	0.532000													7	7					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	71029628	71029628	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:71029628G>A	ENST00000334414.6	-	2	318	c.274C>T	c.(274-276)Cga>Tga	p.R92*	PTPRB_ENST00000538174.2_5'UTR|PTPRB_ENST00000550358.1_Nonsense_Mutation_p.R92*|PTPRB_ENST00000551525.1_Nonsense_Mutation_p.R91*	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	0	Fibronectin type-III 1.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CAGGTCCATCGGGGTGCCTGG	0.547000													8	4					0	0	1	0	0
RGS1	5996	broad.mit.edu	37	1	192548321	192548321	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:192548321A>G	ENST00000367459.3	+	5	565	c.499A>G	c.(499-501)Acc>Gcc	p.T167A		NM_002922.3	NP_002913.3	Q08116	RGS1_HUMAN	regulator of G-protein signaling 1	167	RGS.				immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of signal transduction	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			kidney(8)|large_intestine(1)|lung(13)	22		Breast(1374;0.188)				TAAAGCACCAACCCCCACGTG	0.348000													15	101					0	0	1	0	0
CYP4F8	11283	broad.mit.edu	37	19	15734183	15734183	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:15734183G>A	ENST00000441682.2	+	0	977							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						CCTGCTGAGCGAGGTGGGCCT	0.532000													26	21					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136562596	136562596	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:136562596C>T	ENST00000264162.2	-	10	4215	c.4205G>A	c.(4204-4206)gGa>gAa	p.G1402E		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1402	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		AATGCTGAGTCCTTTGCCATC	0.473000													36	24					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50758484	50758484	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:50758484G>A	ENST00000404971.1	-	12	3687	c.2348C>T	c.(2347-2349)tCc>tTc	p.S783F	NRXN1_ENST00000406859.3_Missense_Mutation_p.S743F|NRXN1_ENST00000405472.3_Missense_Mutation_p.S735F|NRXN1_ENST00000401669.2_Missense_Mutation_p.S743F|NRXN1_ENST00000406316.2_Missense_Mutation_p.S743F|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000402717.3_Missense_Mutation_p.S735F	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	743	Laminin G-like 4.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GAACCGTAAGGAAACATCCTC	0.512000													15	5					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28540237	28540237	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:28540237C>T	ENST00000452236.2	-	4	4046	c.3429G>A	c.(3427-3429)tgG>tgA	p.W1143*		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	1143					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						ttctgtttttccaagcttcta	0.303000													22	21					0	0	1	0	0
ITGA10	8515	broad.mit.edu	37	1	145537180	145537180	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:145537180C>T	ENST00000369304.3	+	19	2526	c.2351C>T	c.(2350-2352)cCc>cTc	p.P784L	ITGA10_ENST00000538811.1_Missense_Mutation_p.P653L|ITGA10_ENST00000539363.1_Missense_Mutation_p.P641L	NM_003637.3	NP_003628.2	O75578	ITA10_HUMAN	integrin, alpha 10	784					cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			NS(1)|breast(2)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TTCCAGGTCCCCTTCTCAAAG	0.463000													72	25					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	121980750	121980750	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:121980750G>A	ENST00000498619.1	+	4	1306	c.868G>A	c.(868-870)Ggc>Agc	p.G290S	CASR_ENST00000490131.1_Missense_Mutation_p.G290S|CASR_ENST00000296154.5_Missense_Mutation_p.G290S	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	290					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CAATATCACGGGCAAGATCTG	0.567000													22	75					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201030572	201030572	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:201030572G>A	ENST00000362061.3	-	25	3304	c.3078C>T	c.(3076-3078)tcC>tcT	p.S1026S	CACNA1S_ENST00000367338.3_Silent_p.S1026S	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	1026	Dihydropyridine binding (By similarity).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CCTCCGCATTGGAGTCTATGG	0.537000													16	56					0	0	1	0	0
ERBB3	2065	broad.mit.edu	37	12	56487190	56487190	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:56487190C>T	ENST00000267101.3	+	12	1776	c.1336C>T	c.(1336-1338)Ctg>Ttg	p.L446L	ERBB3_ENST00000415288.2_Silent_p.L387L|ERBB3_ENST00000450146.2_Intron	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	446					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CTTCCGATCCCTGAAGGAAAT	0.493000													16	48					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	148080841	148080841	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:148080841C>T	ENST00000361727.3	+	22	4092	c.3576C>T	c.(3574-3576)gcC>gcT	p.A1192A	CNTNAP2_ENST00000463592.2_3'UTR|CNTNAP2_ENST00000538075.1_Silent_p.A251A	NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	1192	Laminin G-like 4.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CTCTCAAGGCCGCCTTGAGGC	0.582000										HNSCC(39;0.1)			15	23					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175048720	175048720	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:175048720G>A	ENST00000239462.4	+	3	774	c.661G>A	c.(661-663)Gaa>Aaa	p.E221K		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	221	EGF-like 2.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CCAGTGCCACGAAGACTTCAT	0.677000													11	2					0	0	1	0	0
BLNK	29760	broad.mit.edu	37	10	97956669	97956669	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:97956669C>T	ENST00000224337.5	-	16	1387	c.1246G>A	c.(1246-1248)Gaa>Aaa	p.E416K	BLNK_ENST00000413476.2_Intron|BLNK_ENST00000371176.2_Missense_Mutation_p.E393K|BLNK_ENST00000427367.2_Intron	NM_013314.3	NP_037446.1	Q8WV28	BLNK_HUMAN	B-cell linker	416	SH2.				B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(2)|stomach(1)	14		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		CTGACCTCTTCACCATTTTTC	0.308000													21	8					0	0	1	0	0
ZNF215	7762	broad.mit.edu	37	11	6977574	6977574	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:6977574C>T	ENST00000278319.5	+	7	1954	c.1366C>T	c.(1366-1368)Cat>Tat	p.H456Y	ZNF215_ENST00000414517.2_Missense_Mutation_p.H456Y|ZNF215_ENST00000529903.1_Intron	NM_013250.2	NP_037382.2	Q9UL58	ZN215_HUMAN	zinc finger protein 215	456					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(2)|skin(4)	32				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		TCCAACACTCCATTTTGGAAA	0.398000													20	20					0	0	1	0	0
PI3	5266	broad.mit.edu	37	20	43804674	43804674	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:43804674C>T	ENST00000243924.3	+	2	299	c.252C>T	c.(250-252)gcC>gcT	p.A84A		NM_002638.3	NP_002629.1	P19957	ELAF_HUMAN	peptidase inhibitor 3, skin-derived	84	WAP.				copulation	proteinaceous extracellular matrix	serine-type endopeptidase inhibitor activity			large_intestine(1)|lung(5)|skin(1)	7		Myeloproliferative disorder(115;0.0122)				TCCGGTGCGCCATGTTGAATC	0.512000													36	78					0	0	1	0	0
OR1B1	347169	broad.mit.edu	37	9	125390981	125390981	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:125390981C>T	ENST00000304833.3	-	1	871	c.834G>A	c.(832-834)atG>atA	p.M278I	RP11-64P14.7_ENST00000431442.1_RNA|RP11-64P14.7_ENST00000419604.1_RNA	NM_001004450.1	NP_001004450.1	Q8NGR6	OR1B1_HUMAN	olfactory receptor, family 1, subfamily B, member 1	278					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|prostate(1)	16						CTGAAGCCACCATGTCCTGAT	0.502000													20	16					0	0	1	0	0
CYP8B1	1582	broad.mit.edu	37	3	42916049	42916049	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:42916049G>A	ENST00000316161.4	-	1	1584	c.1260C>T	c.(1258-1260)ttC>ttT	p.F420F	CYP8B1_ENST00000437102.1_Silent_p.F420F|ACKR2_ENST00000471537.1_Intron|KRBOX1_ENST00000426937.1_Intron	NM_004391.2	NP_004382.2	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B, polypeptide 1	420					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(5)	23				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		TGCCTGTCTTGAAGAAGTCCA	0.547000													38	86					0	0	1	0	0
DHX15	1665	broad.mit.edu	37	4	24543635	24543635	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:24543635G>A	ENST00000336812.4	-	8	1502	c.1346C>T	c.(1345-1347)cCt>cTt	p.P449L		NM_001358.2	NP_001349.2	O43143	DHX15_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 15	449	Helicase C-terminal.				mRNA processing	U12-type spliceosomal complex	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	30		Breast(46;0.0503)				TCTGATTCGAGGATTGTAGAC	0.428000													7	18					0	0	1	0	0
PRDM10	56980	broad.mit.edu	37	11	129802083	129802083	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:129802083G>A	ENST00000358825.5	-	10	1432	c.1201C>T	c.(1201-1203)Cca>Tca	p.P401S	PRDM10_ENST00000423662.2_Missense_Mutation_p.P315S|PRDM10_ENST00000304538.6_Missense_Mutation_p.P315S|PRDM10_ENST00000360871.3_Missense_Mutation_p.P401S|PRDM10_ENST00000526082.1_Missense_Mutation_p.P315S|PRDM10_ENST00000528746.1_Missense_Mutation_p.P375S	NM_020228.2	NP_064613.2	Q9NQV6	PRD10_HUMAN	PR domain containing 10	401					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(14)|lung(15)|pancreas(2)|skin(1)|stomach(3)|urinary_tract(2)	48	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		CGTCGACCTGGACCGAATCGC	0.547000													13	27					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139153460	139153460	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:139153460G>T	ENST00000395297.1	-	17	3941	c.3771C>A	c.(3769-3771)aaC>aaA	p.N1257K		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1257										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CCAGGGTGCTGTTGTTGTACA	0.547000										HNSCC(54;0.14)			24	18					6.44725e-10	6.52002e-10	1	1	0
SLC38A3	10991	broad.mit.edu	37	3	50252157	50252157	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:50252157G>A	ENST00000420502.1	+	0	409							Q99624	S38A3_HUMAN	solute carrier family 38, member 3						cellular nitrogen compound metabolic process|sodium ion transport	integral to plasma membrane	antiporter activity|L-alanine transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-histidine transmembrane transporter activity|symporter activity			breast(1)|cervix(1)|endometrium(1)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(193;0.000275)|KIRC - Kidney renal clear cell carcinoma(197;0.00548)|Kidney(197;0.00615)	L-Asparagine(DB00174)|L-Glutamine(DB00130)|L-Histidine(DB00117)	CGGCATCCTGGGACTCGCCTA	0.542000													9	16					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123427578	123427578	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:123427578C>T	ENST00000360772.3	-	16	2485	c.2107G>A	c.(2107-2109)Gag>Aag	p.E703K	MYLK_ENST00000475616.1_Missense_Mutation_p.E703K|MYLK_ENST00000360304.3_Missense_Mutation_p.E703K|MYLK_ENST00000359169.1_Missense_Mutation_p.E703K|MYLK_ENST00000346322.5_Missense_Mutation_p.E634K			Q15746	MYLK_HUMAN	myosin light chain kinase	703	Ig-like C2-type 5.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GTGCGGACCTCTCCAGCGCTG	0.597000													28	27					0	0	1	0	0
HSDL1	83693	broad.mit.edu	37	16	84163306	84163306	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:84163306G>A	ENST00000219439.4	-	5	917	c.741C>T	c.(739-741)atC>atT	p.I247I	HSDL1_ENST00000434463.3_Silent_p.I192I	NM_001146051.1|NM_031463.4	NP_001139523.1|NP_113651.4	Q3SXM5	HSDL1_HUMAN	hydroxysteroid dehydrogenase like 1	247						mitochondrion	oxidoreductase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7						CATAGAAAGGGATTAGACTCT	0.463000													13	63					0	0	1	0	0
KIAA1211	57482	broad.mit.edu	37	4	57173805	57173805	+	Silent	SNP	G	G	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:57173805G>T	ENST00000504228.1	+	3	330	c.225G>T	c.(223-225)ctG>ctT	p.L75L	KIAA1211_ENST00000541073.1_Silent_p.L68L|KIAA1211_ENST00000264229.6_Silent_p.L75L			Q6ZU35	K1211_HUMAN	KIAA1211	75										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					ATCTGTTCCTGACCAGTCCCA	0.493000													18	7					1.56452e-12	1.58487e-12	1	1	0
COL5A3	50509	broad.mit.edu	37	19	10089914	10089914	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:10089914C>T	ENST00000264828.3	-	39	2853	c.2766_splice	c.e39-1	p.G923_splice		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	923	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			TCCTGTCTTTCCCTGGTGAGG	0.592000													32	16					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578263	7578263	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:7578263G>A	ENST00000420246.2	-	6	718	c.586C>T	c.(586-588)Cga>Tga	p.R196*	TP53_ENST00000574684.1_Intron|TP53_ENST00000359597.4_Nonsense_Mutation_p.R196*|TP53_ENST00000455263.2_Nonsense_Mutation_p.R196*|TP53_ENST00000413465.2_Nonsense_Mutation_p.R196*|TP53_ENST00000445888.2_Nonsense_Mutation_p.R196*|TP53_ENST00000269305.4_Nonsense_Mutation_p.R196*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	196	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R196*(167)|p.R64*(14)|p.R103*(14)|p.0?(8)|p.R196fs*51(7)|p.?(5)|p.A189_V197delAPPQHLIRV(4)|p.P191_E198>Q(3)|p.R196R(2)|p.I195fs*50(1)|p.R64fs*>27(1)|p.R103fs*51(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.P98_E105>Q(1)|p.I195fs*12(1)|p.P59_E66>Q(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCTTCCACTCGGATAAGATGC	0.552000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			29	7					0	0	1	0	0
IGHV1-3	28473	broad.mit.edu	37	14	106471464	106471464	+	RNA	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:106471464C>T	ENST00000390595.2	-	0	174																											AAGGTGTATCCAGAAGCCTTG	0.557000													16	114					0	0	1	0	0
OR5B12	390191	broad.mit.edu	37	11	58206937	58206937	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:58206937C>T	ENST00000302572.2	-	1	709	c.688G>A	c.(688-690)Gaa>Aaa	p.E230K		NM_001004733.2	NP_001004733.1	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B, member 12	230					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(6)|liver(1)|lung(28)|ovary(1)|prostate(3)|skin(1)	40	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TGGCGTCCTTCAGGTGAGCGC	0.403000													10	28					0	0	1	0	0
OPCML	4978	broad.mit.edu	37	11	132527066	132527066	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:132527066C>T	ENST00000331898.7	-	2	894	c.316G>A	c.(316-318)Gat>Aat	p.D106N	OPCML_ENST00000524381.1_Missense_Mutation_p.D99N|OPCML_ENST00000529038.1_5'UTR|OPCML_ENST00000374778.4_Missense_Mutation_p.D65N|OPCML_ENST00000541867.1_Missense_Mutation_p.D106N	NM_002545.3	NP_002536.1	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion molecule-like	106	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			endometrium(5)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|skin(2)|urinary_tract(8)	47	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		TCATACACATCCACATTTTGG	0.502000													20	38					0	0	1	0	0
LRRC55	219527	broad.mit.edu	37	11	56949442	56949442	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:56949442C>T	ENST00000497933.1	+	1	222	c.75C>T	c.(73-75)tcC>tcT	p.S25S		NM_001005210.2	NP_001005210.1	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	0						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|skin(2)	25						CTCTCGATTCCATGGACACAG	0.607000													12	24					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20177255	20177255	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:20177255C>T	ENST00000245957.5	+	16	1708	c.1632C>T	c.(1630-1632)ttC>ttT	p.F544F	C20orf26_ENST00000377309.2_5'UTR|C20orf26_ENST00000389656.3_5'UTR	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	544										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		TTGAAGATTTCATCTACTTCA	0.448000													21	56					0	0	1	0	0
UBE2J2	118424	broad.mit.edu	37	1	1192649	1192649	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:1192649G>A	ENST00000347370.2	-	4	531	c.58C>T	c.(58-60)Cct>Tct	p.P20S	UBE2J2_ENST00000339385.6_Missense_Mutation_p.P37S|UBE2J2_ENST00000349431.6_Missense_Mutation_p.P72S|UBE2J2_ENST00000400930.4_Missense_Mutation_p.P88S|UBE2J2_ENST00000348298.7_Missense_Mutation_p.P20S|UBE2J2_ENST00000491779.1_5'UTR|UBE2J2_ENST00000360466.2_Missense_Mutation_p.P72S|UBE2J2_ENST00000400929.2_Missense_Mutation_p.P20S	NM_194458.1	NP_919440.1	Q8N2K1	UB2J2_HUMAN	ubiquitin-conjugating enzyme E2, J2	72					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity			cervix(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	13	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.66e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.53e-21)|Colorectal(212;0.00019)|COAD - Colon adenocarcinoma(227;0.000215)|Kidney(185;0.00255)|BRCA - Breast invasive adenocarcinoma(365;0.00266)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0371)|Lung(427;0.205)		GGTTTGAAAGGAAATTCTCTG	0.507000													8	79					0	0	1	0	0
SLA	6503	broad.mit.edu	37	8	134072357	134072357	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:134072357G>A	ENST00000338087.5	-	3	868	c.49C>T	c.(49-51)Ccc>Tcc	p.P17S	SLA_ENST00000518565.1_5'UTR|TG_ENST00000377869.1_Intron|SLA_ENST00000427060.2_Missense_Mutation_p.P57S|SLA_ENST00000395352.3_Missense_Mutation_p.P34S|SLA_ENST00000524345.1_Intron|TG_ENST00000519543.1_Intron|TG_ENST00000542445.1_Intron|SLA_ENST00000517648.1_Missense_Mutation_p.P34S|TG_ENST00000220616.4_Intron	NM_001045556.2	NP_001039021.1	Q13239	SLAP1_HUMAN	Src-like-adaptor	17						endosome	SH3/SH2 adaptor activity	p.P17T(1)		central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(6)|prostate(1)|skin(1)	17	all_epithelial(106;3.51e-21)|Lung NSC(106;4.24e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0279)|Breast(495;0.037)	BRCA - Breast invasive adenocarcinoma(115;0.000701)			TCCGGGTTGGGCAGGGGCCTC	0.577000													74	176					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183245273	183245273	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:183245273C>T	ENST00000511685.1	+	2	223	c.100C>T	c.(100-102)Cgg>Tgg	p.R34W	TENM3_ENST00000406950.2_Missense_Mutation_p.R34W					teneurin transmembrane protein 3									p.R34W(1)									TGAGGAGTGCCGGGTACCCAC	0.512000													5	31					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16248807	16248807	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:16248807C>T	ENST00000205557.7	-	28	3993	c.3964G>A	c.(3964-3966)Ggg>Agg	p.G1322R		NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	1322	ABC transporter 2.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		ATCCAGATCCCACCCTCAGCT	0.692000													5	2					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179621427	179621427	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:179621427T>G	ENST00000589042.1	-	46	11000	c.10776A>C	c.(10774-10776)aaA>aaC	p.K3592N	TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Missense_Mutation_p.K3421N|TTN_ENST00000360870.5_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000590773.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3278							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGAGATATTTTGCTCTCCT	0.423000													8	49					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29296798	29296798	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:29296798C>T	ENST00000331664.5	-	1	329	c.330G>A	c.(328-330)atG>atA	p.M110I		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	110					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						TATCCTTAGCCATGTGGCTTT	0.468000													88	31					0	0	1	0	0
EZR	7430	broad.mit.edu	37	6	159192345	159192345	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:159192345G>A	ENST00000367075.3	-	9	1058	c.890C>T	c.(889-891)cCt>cTt	p.P297L	EZR_ENST00000392177.4_Missense_Mutation_p.P265L|EZR_ENST00000337147.7_Missense_Mutation_p.P297L	NM_001111077.1	NP_001104547.1	P15311	EZRI_HUMAN	ezrin	297	Interaction with SCYL3.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding		EZR/ROS1(4)	breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)	15		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		GATGGTGTCAGGCTTCCTGCG	0.592000			T	ROS1	NSCLC								36	22					0	0	1	0	0
RPLP2	6181	broad.mit.edu	37	11	810284	810284	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:810284C>T	ENST00000321153.4	+	2	444	c.50C>T	c.(49-51)tCc>tTc	p.S17F	RPLP2_ENST00000532004.1_Intron|RPLP2_ENST00000530797.1_Missense_Mutation_p.S17F	NM_001004.3	NP_000995.1	P05387	RLA2_HUMAN	ribosomal protein, large, P2	17					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome			lung(1)	1		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGCAACTCCTCCCCCAGCGCC	0.687000													18	27					0	0	1	0	0
LMX1A	4009	broad.mit.edu	37	1	165218847	165218847	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:165218847G>A	ENST00000342310.3	-	4	676	c.294C>T	c.(292-294)ttC>ttT	p.F98F	LMX1A_ENST00000294816.2_Silent_p.F98F|LMX1A_ENST00000367893.4_Silent_p.F98F	NM_177398.3	NP_796372.1	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	98	LIM zinc-binding 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|central_nervous_system(3)|cervix(2)|endometrium(4)|large_intestine(6)|lung(10)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)	35	all_hematologic(923;0.248)					CGATGGCCTCGAAGCAGCCCC	0.542000													14	21					0	0	1	0	0
LMAN2L	81562	broad.mit.edu	37	2	97403781	97403781	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:97403781G>A	ENST00000264963.4	-	2	233	c.211C>T	c.(211-213)Ctg>Ttg	p.L71L	LMAN2L_ENST00000537039.1_Intron|LMAN2L_ENST00000426463.2_5'UTR|LMAN2L_ENST00000534882.1_Intron|LMAN2L_ENST00000377079.4_Silent_p.L71L	NM_030805.3	NP_110432.1	Q9H0V9	LMA2L_HUMAN	lectin, mannose-binding 2-like	71	L-type lectin-like.				ER to Golgi vesicle-mediated transport|protein folding|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi membrane|integral to membrane	mannose binding|metal ion binding			NS(1)|breast(1)|endometrium(1)|lung(2)|skin(1)|urinary_tract(1)	7						AGATTCCACAGTGAGGAACTG	0.498000													21	5					0	0	1	0	0
CASS4	57091	broad.mit.edu	37	20	55028128	55028128	+	Silent	SNP	G	G	A	rs142247733		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:55028128G>A	ENST00000371336.3	+	5	2097	c.1896G>A	c.(1894-1896)agG>agA	p.R632R	CASS4_ENST00000434344.1_Intron|CASS4_ENST00000360314.3_Silent_p.R632R	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	632					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						CTAAGCAAAGGGAAGATGAAC	0.408000													26	25					0	0	1	0	0
LYRM7	90624	broad.mit.edu	37	5	130506715	130506715	+	Translation_Start_Site	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:130506715T>C	ENST00000379380.4	+	1	213	c.2T>C	c.(1-3)aTg>aCg	p.M1T	HINT1_ENST00000506207.1_Intron|LYRM7_ENST00000510516.1_Start_Codon_SNP_p.M1T|LYRM7_ENST00000507584.1_Start_Codon_SNP_p.M1T	NM_181705.2	NP_859056.2	Q5U5X0	LYRM7_HUMAN	LYR motif containing 7	1										upper_aerodigestive_tract(1)	1		all_cancers(142;0.0377)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGGAGAGCCATGGGACGGGCA	0.617000													9	0					0	0	1	0	0
TMOD3	29766	broad.mit.edu	37	15	52179833	52179833	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr15:52179833G>A	ENST00000308580.7	+	4	612	c.331G>A	c.(331-333)Gaa>Aaa	p.E111K	RP11-56B16.5_ENST00000558142.1_RNA|TMOD3_ENST00000544199.1_Missense_Mutation_p.E111K	NM_014547.4	NP_055362.1	Q9NYL9	TMOD3_HUMAN	tropomodulin 3 (ubiquitous)	111						cytoplasm|cytoskeleton	actin binding|tropomyosin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|stomach(1)	14				all cancers(107;0.00194)		TTTTACAGAAGAAAAAGTGTC	0.343000													48	13					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139160798	139160798	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:139160798C>T	ENST00000395297.1	-	14	3583	c.3413G>A	c.(3412-3414)gGa>gAa	p.G1138E		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1138										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CAGGTGAATTCCATCTTCCAA	0.363000										HNSCC(54;0.14)			20	50					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31901557	31901557	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:31901557C>T	ENST00000456570.1	+	3	482	c.427C>T	c.(427-429)Cgc>Tgc	p.R143C	C2_ENST00000299367.5_Missense_Mutation_p.R205C|CFB_ENST00000477310.1_Intron|C2_ENST00000418949.2_Missense_Mutation_p.R205C|CFB_ENST00000556679.1_Missense_Mutation_p.R143C|C2_ENST00000442278.2_Missense_Mutation_p.R73C|C2_ENST00000452323.2_Missense_Mutation_p.R82C|C2_ENST00000469372.1_Silent_p.A36A			P00751	CFAB_HUMAN	complement factor B	219	Sushi 2.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						GCCCATCTGCCGCCGTGAGTA	0.642000													56	23					0	0	1	0	0
CEP72	55722	broad.mit.edu	37	5	639262	639262	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:639262T>G	ENST00000264935.5	+	8	1355	c.1265T>G	c.(1264-1266)cTc>cGc	p.L422R	CEP72_ENST00000444221.1_3'UTR	NM_018140.3	NP_060610.2	Q9P209	CEP72_HUMAN	centrosomal protein 72kDa	422					G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|spindle organization	centrosome|cytosol				autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|liver(1)|lung(5)|ovary(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	20			Epithelial(17;0.000339)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|Lung(60;0.0863)			CAGGCGGCGCTCCTGGAGACG	0.642000													93	11					0	0	1	0	0
GPRC6A	222545	broad.mit.edu	37	6	117114040	117114040	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:117114040C>T	ENST00000310357.3	-	6	2067	c.2046G>A	c.(2044-2046)ctG>ctA	p.L682L	GPRC6A_ENST00000368549.3_Silent_p.L611L|GPRC6A_ENST00000530250.1_Silent_p.L507L	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	682					response to amino acid stimulus		G-protein coupled receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		GCAAAATTTTCAGAGACTTCG	0.413000													23	16					0	0	1	0	0
IFNL3	282617	broad.mit.edu	37	19	39734519	39734519	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:39734519C>T	ENST00000413851.2	-	4	475	c.437G>A	c.(436-438)aGg>aAg	p.R146K		NM_172139.2	NP_742151.2			interferon, lambda 3																		GCCCCGGGTCCTGGGCCCTGC	0.682000													10	25					0	0	1	0	0
STIM1	6786	broad.mit.edu	37	11	4112756	4112756	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:4112756C>T	ENST00000300737.4	+	12	2355	c.1786C>T	c.(1786-1788)Ctg>Ttg	p.L596L	STIM1_ENST00000533977.1_Silent_p.L423L|STIM1_ENST00000527651.1_3'UTR	NM_003156.3	NP_003147.2	Q13586	STIM1_HUMAN	stromal interaction molecule 1	596					activation of store-operated calcium channel activity|calcium ion transport|detection of calcium ion|platelet activation	integral to endoplasmic reticulum membrane|integral to plasma membrane|microtubule	calcium ion binding|microtubule plus-end binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|liver(1)|lung(14)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30		Breast(177;0.00159)|Medulloblastoma(188;0.00258)|all_neural(188;0.0233)		BRCA - Breast invasive adenocarcinoma(625;0.114)|LUSC - Lung squamous cell carcinoma(625;0.141)		GGCCCACAGCCTGATGGAGCT	0.622000													16	54					0	0	1	0	0
EIF2S3	1968	broad.mit.edu	37	X	24089795	24089795	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:24089795T>A	ENST00000253039.4	+	10	1386	c.1133T>A	c.(1132-1134)cTt>cAt	p.L378H		NM_001415.3	NP_001406.1	P41091	IF2G_HUMAN	eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa	378						cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(1)|lung(4)|ovary(1)	12						TATTTCCTGCTTAGACGGCTT	0.433000													42	8					0	0	1	0	0
PDYN	5173	broad.mit.edu	37	20	1961130	1961130	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:1961130C>T	ENST00000217305.2	-	4	829	c.604G>A	c.(604-606)Gac>Aac	p.D202N	RP4-684O24.5_ENST00000446562.1_RNA|PDYN_ENST00000539905.1_Missense_Mutation_p.D202N|PDYN_ENST00000540134.1_Missense_Mutation_p.D202N	NM_001190892.1|NM_001190898.2|NM_024411.4	NP_001177821.1|NP_001177827.1|NP_077722.1	P01213	PDYN_HUMAN	prodynorphin	202					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TTGTACAGGTCCTCATGGCCC	0.587000													50	140					0	0	1	0	0
PTGIS	5740	broad.mit.edu	37	20	48130862	48130862	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:48130862A>T	ENST00000244043.4	-	7	955	c.926T>A	c.(925-927)gTc>gAc	p.V309D	PTGIS_ENST00000478971.1_5'UTR	NM_000961.3	NP_000952.1	Q16647	PTGIS_HUMAN	prostaglandin I2 (prostacyclin) synthase	309					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|ovary(3)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	27			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	CTCTCCGCGGACAGCAGCCAG	0.582000													26	56					0	0	1	0	0
PLXDC1	57125	broad.mit.edu	37	17	37264482	37264482	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:37264482C>T	ENST00000315392.4	-	5	697	c.486G>A	c.(484-486)ggG>ggA	p.G162G	PLXDC1_ENST00000493200.1_5'UTR|PLXDC1_ENST00000539608.1_Silent_p.G89G|PLXDC1_ENST00000394316.2_Silent_p.G162G|PLXDC1_ENST00000444911.2_Silent_p.G122G	NM_020405.4	NP_065138.2	Q8IUK5	PXDC1_HUMAN	plexin domain containing 1	162					angiogenesis	cytoplasm|extracellular region|integral to membrane|tight junction				kidney(2)|large_intestine(6)|liver(1)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						GGATCACGTCCCCCATGAAGA	0.572000													13	87					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92523157	92523157	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:92523157C>T	ENST00000298047.6	+	7	4401	c.4384C>T	c.(4384-4386)Cag>Tag	p.Q1462*	FAT3_ENST00000409404.2_Nonsense_Mutation_p.Q1462*|FAT3_ENST00000525166.1_Nonsense_Mutation_p.Q1312*			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1462	Cadherin 14.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGAATTCTCTCAGCCGAATTA	0.413000										TCGA Ovarian(4;0.039)			17	41					0	0	1	0	0
NR1H2	7376	broad.mit.edu	37	19	50881477	50881477	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:50881477G>A	ENST00000253727.5	+	5	488	c.253G>A	c.(253-255)Gag>Aag	p.E85K	NR1H2_ENST00000598168.1_Missense_Mutation_p.E85K|NR1H2_ENST00000411902.2_Intron|NR1H2_ENST00000599105.1_Missense_Mutation_p.E85K|NR1H2_ENST00000542413.1_5'UTR|NR1H2_ENST00000593926.1_Missense_Mutation_p.E85K	NM_007121.5	NP_009052.3	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	85					negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(2)	8		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		GCTGGGCCACGAGCTTTGCCG	0.622000													75	148					0	0	1	0	0
CHPF2	54480	broad.mit.edu	37	7	150935148	150935148	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:150935148G>A	ENST00000035307.2	+	4	3213	c.1700G>A	c.(1699-1701)cGa>cAa	p.R567Q	CHPF2_ENST00000495645.1_Missense_Mutation_p.R559Q	NM_019015.1	NP_061888.1	Q9P2E5	CHPF2_HUMAN	chondroitin polymerizing factor 2	567						Golgi cisterna membrane|integral to membrane	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(4)|prostate(1)|skin(3)	17						CTCGCTGTGCGAGCAGAGGCC	0.632000													25	25					0	0	1	0	0
SLC4A3	6508	broad.mit.edu	37	2	220505162	220505162	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:220505162C>T	ENST00000358055.3	+	21	3800	c.3288C>T	c.(3286-3288)atC>atT	p.I1096I	SLC4A3_ENST00000317151.3_Silent_p.I1096I|SLC4A3_ENST00000373762.3_Silent_p.I1123I|SLC4A3_ENST00000273063.6_Silent_p.I1123I|SLC4A3_ENST00000373760.2_Silent_p.I1096I			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	1096	Membrane (anion exchange).			I -> M (in Ref. 2; AAB05850).	bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCCTGTCCATCGTCATGGGGG	0.617000													17	74					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152469461	152469461	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:152469461G>A	ENST00000367255.5	-	137	25296	c.24695C>T	c.(24694-24696)tCt>tTt	p.S8232F	SYNE1_ENST00000347037.5_5'UTR|SYNE1_ENST00000356820.4_Missense_Mutation_p.S2756F|SYNE1_ENST00000354674.4_Missense_Mutation_p.S387F|SYNE1_ENST00000448038.1_Missense_Mutation_p.S8161F|SYNE1_ENST00000423061.1_Missense_Mutation_p.S8161F|SYNE1_ENST00000539504.1_Missense_Mutation_p.S387F|SYNE1_ENST00000265368.4_Missense_Mutation_p.S8232F|SYNE1_ENST00000341594.5_Missense_Mutation_p.S7844F	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8232					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CAGAGCTGCAGAGTCTTCCAG	0.597000										HNSCC(10;0.0054)			16	21					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17053502	17053502	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:17053502G>A	ENST00000418129.2	+	2	2751	c.2286G>A	c.(2284-2286)aaG>aaA	p.K762K	PLCL2_ENST00000396755.2_Silent_p.K762K|PLCL2_ENST00000432376.1_Silent_p.K762K	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	888	C2.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						GAGGAGGAAAGCCTCATAAAA	0.468000													20	31					0	0	1	0	0
GIMAP2	26157	broad.mit.edu	37	7	150390074	150390074	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:150390074G>A	ENST00000223293.5	+	3	794	c.700G>A	c.(700-702)Gaa>Aaa	p.E234K		NM_015660.2	NP_056475.1	Q9UG22	GIMA2_HUMAN	GTPase, IMAP family member 2	234						integral to membrane	GTP binding			kidney(1)|large_intestine(1)|lung(8)|skin(2)|urinary_tract(1)	13			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGGATCAGATGAAAGAGTAAA	0.403000													24	26					0	0	1	0	0
MMEL1	79258	broad.mit.edu	37	1	2523050	2523050	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:2523050G>A	ENST00000288709.6	-	23	2399	c.2159C>T	c.(2158-2160)cCc>cTc	p.P720L	MMEL1_ENST00000378412.3_Missense_Mutation_p.P729L|MMEL1_ENST00000502556.1_Missense_Mutation_p.P572L	NM_033467.3	NP_258428.2	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	729					proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity			cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|urinary_tract(1)	27	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		GGCGAACTCGGGCCGGTAGGA	0.642000													118	58					0	0	1	0	0
OR10S1	219873	broad.mit.edu	37	11	123847742	123847742	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:123847742G>A	ENST00000531945.1	-	1	746	c.657C>T	c.(655-657)atC>atT	p.I219I		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	219					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CTGCAGCCACGATGCCAATGC	0.562000													21	23					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56363594	56363594	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:56363594G>A	ENST00000301295.6	+	2	570	c.148G>A	c.(148-150)Gca>Aca	p.A50T	NLRP4_ENST00000346986.5_Missense_Mutation_p.A50T	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	50	DAPIN.						ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GGTCAAAAAAGCATCCCGGGA	0.403000													18	19					0	0	1	0	0
MAP3K12	7786	broad.mit.edu	37	12	53879241	53879241	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:53879241G>A	ENST00000267079.2	-	6	966	c.741C>T	c.(739-741)gaC>gaT	p.D247D	MAP3K12_ENST00000547035.1_Silent_p.D280D|MAP3K12_ENST00000547488.1_Silent_p.D280D	NM_001193511.1|NM_006301.3	NP_001180440.1|NP_006292.3	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase 12	247	Protein kinase.				histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(2)|breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	37						TCACCACATCGTCGTAGGTGA	0.522000													93	93					0	0	1	0	0
C3orf20	84077	broad.mit.edu	37	3	14724304	14724304	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:14724304C>T	ENST00000253697.3	+	3	536	c.84C>T	c.(82-84)ctC>ctT	p.L28L	C3orf20_ENST00000435614.1_Intron|C3orf20_ENST00000412910.1_Intron	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	28						cytoplasm|integral to membrane		p.L28L(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						TCTCCAAACTCCTCATGATCT	0.473000													25	52					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	151127055	151127055	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:151127055C>T	ENST00000474524.1	+	38	5778	c.5740C>T	c.(5740-5742)Ctc>Ttc	p.L1914F	MED12L_ENST00000273432.4_Intron	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	1914	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CCAGGCTGCTCTCTTTGCTGC	0.522000													50	41					0	0	1	0	0
EFEMP2	30008	broad.mit.edu	37	11	65637338	65637338	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:65637338G>A	ENST00000307998.6	-	7	947	c.717C>T	c.(715-717)ttC>ttT	p.F239F	EFEMP2_ENST00000528176.1_Silent_p.F239F	NM_016938.4	NP_058634.4	O95967	FBLN4_HUMAN	EGF containing fibulin-like extracellular matrix protein 2	239	EGF-like 4; calcium-binding (Potential).				blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21				READ - Rectum adenocarcinoma(159;0.169)		CACTGCAGGAGAAGCCATCCC	0.607000													38	39					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135427865	135427865	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:135427865C>T	ENST00000394143.1	+	6	2291	c.2000C>T	c.(1999-2001)tCt>tTt	p.S667F	GPR112_ENST00000394141.1_Missense_Mutation_p.S462F|GPR112_ENST00000370652.1_Missense_Mutation_p.S667F|GPR112_ENST00000287534.4_Missense_Mutation_p.S604F|GPR112_ENST00000412101.1_Missense_Mutation_p.S462F	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	667					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CTGCTGGCATCTATGAACACA	0.443000													50	8					0	0	1	0	0
IKZF3	22806	broad.mit.edu	37	17	37922292	37922292	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:37922292G>A	ENST00000346872.3	-	8	1342	c.1281C>T	c.(1279-1281)ctC>ctT	p.L427L	IKZF3_ENST00000439167.2_Silent_p.L354L|IKZF3_ENST00000351680.3_Silent_p.L388L|IKZF3_ENST00000535189.1_Silent_p.L393L|IKZF3_ENST00000439016.2_Silent_p.L332L|IKZF3_ENST00000467757.1_Silent_p.L371L|IKZF3_ENST00000377952.2_Silent_p.L206L|IKZF3_ENST00000377944.3_Silent_p.L284L|IKZF3_ENST00000394189.2_Silent_p.L245L|IKZF3_ENST00000377945.3_Silent_p.L293L|IKZF3_ENST00000583368.1_Silent_p.L180L|IKZF3_ENST00000346243.3_Silent_p.L349L|IKZF3_ENST00000377958.2_Silent_p.L340L|IKZF3_ENST00000350532.3_Silent_p.L388L	NM_012481.4	NP_036613.2	Q9UKT9	IKZF3_HUMAN	IKAROS family zinc finger 3 (Aiolos)	427					B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(6)|large_intestine(4)|liver(1)|lung(13)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GGGGCTTGAGGAGTTCGTAAG	0.552000													92	19					0	0	1	0	0
OR13C3	138803	broad.mit.edu	37	9	107298474	107298474	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:107298474G>A	ENST00000374781.2	-	1	663	c.621C>T	c.(619-621)ttC>ttT	p.F207F		NM_001001961.1	NP_001001961.1	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C, member 3	207					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(1)|skin(1)	19						TTTCACATGCGAAATGATTGA	0.428000													31	35					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152058866	152058866	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:152058866C>T	ENST00000368806.1	-	3	1356	c.1292G>A	c.(1291-1293)gGa>gAa	p.G431E		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	431							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TTTTGATAATCCTTGGAGTTC	0.463000													25	160					0	0	1	0	0
MET	4233	broad.mit.edu	37	7	116435843	116435843	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:116435843C>T	ENST00000397752.3	+	20	4133	c.3933C>T	c.(3931-3933)ccC>ccT	p.P1311P	MET_ENST00000539704.1_Silent_p.P181P|MET_ENST00000318493.6_Silent_p.P1329P	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	1311	Interaction with RANBP9.|Protein kinase.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			GCCCAGACCCCTTGTAAGTAG	0.428000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)		OREG0003446	type=REGULATORY REGION|Gene=MET|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	71	68					0	0	1	0	0
NEURL2	140825	broad.mit.edu	37	20	44519264	44519264	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:44519264G>A	ENST00000372518.4	-	1	662	c.367C>T	c.(367-369)Ccc>Tcc	p.P123S		NM_001278535.1|NM_080749.2	NP_001265464.1|NP_542787.1	Q9BR09	NEUL2_HUMAN	neuralized E3 ubiquitin protein ligase 2	123	NHR.				intracellular signal transduction					large_intestine(1)|lung(2)	3		Myeloproliferative disorder(115;0.0122)				CCCTCCCGGGGCACGCGGTTG	0.687000													12	53					0	0	1	0	0
POLE	5426	broad.mit.edu	37	12	133218812	133218812	+	Silent	SNP	G	G	A	rs114891564	byFrequency	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:133218812G>A	ENST00000320574.5	-	38	5167	c.5124C>T	c.(5122-5124)ttC>ttT	p.F1708F	POLE_ENST00000535270.1_Silent_p.F1681F	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	1708					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CTTGGTCATCGAACTCCATGA	0.587000								DNA polymerases (catalytic subunits)					26	42					0	0	1	0	0
LPL	4023	broad.mit.edu	37	8	19811727	19811727	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:19811727C>T	ENST00000311322.8	+	5	1108	c.638C>T	c.(637-639)aCc>aTc	p.T213I		NM_000237.2	NP_000228.1	P06858	LIPL_HUMAN	lipoprotein lipase	213					fatty acid biosynthetic process|lipoprotein metabolic process|phospholipid metabolic process|positive regulation of cholesterol storage|positive regulation of sequestering of triglyceride|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	anchored to membrane|chylomicron|plasma membrane|very-low-density lipoprotein particle	heparin binding|lipoprotein lipase activity|phospholipase activity|receptor binding|triglyceride lipase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	36				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	Clofibrate(DB00636)|Gemfibrozil(DB01241)|Orlistat(DB01083)	CACACATTCACCAGAGGGTCC	0.483000													38	50					0	0	1	0	0
PRPF40B	25766	broad.mit.edu	37	12	50036417	50036417	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:50036417G>A	ENST00000261897.1	+	20	2523	c.1972G>A	c.(1972-1974)Gag>Aag	p.E658K	PRPF40B_ENST00000548825.2_Missense_Mutation_p.E693K|FMNL3_ENST00000335154.5_3'UTR|PRPF40B_ENST00000380281.1_Missense_Mutation_p.E671K			Q6NWY9	PR40B_HUMAN	PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)	671					mRNA processing|RNA splicing	nuclear speck				breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34						CCTGGAGTCGGAGCGGATCCG	0.577000													11	9					0	0	1	0	0
CD33	945	broad.mit.edu	37	19	51742905	51742905	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:51742905G>A	ENST00000262262.4	+	7	1078	c.1057G>A	c.(1057-1059)Gac>Aac	p.D353N	CD33_ENST00000600557.1_3'UTR|CD33_ENST00000421133.2_Missense_Mutation_p.D226N	NM_001772.3	NP_001763.3	P20138	CD33_HUMAN	CD33 molecule	353					cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(15)|skin(1)|stomach(1)	24		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	TCCTTCCAAGGACACCTCCAC	0.532000													7	21					0	0	1	0	0
NPHS1	4868	broad.mit.edu	37	19	36339976	36339976	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:36339976G>A	ENST00000378910.5	-	8	913	c.914C>T	c.(913-915)aCc>aTc	p.T305I	NPHS1_ENST00000353632.6_Missense_Mutation_p.T305I	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	305	Ig-like C2-type 3.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TGGCCTCACGGTCATCACCAG	0.662000													17	47					0	0	1	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33564060	33564060	+	Silent	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:33564060T>C	ENST00000321505.4	+	1	240	c.60T>C	c.(58-60)gtT>gtC	p.V20V	KIAA1549L_ENST00000265654.5_Silent_p.V20V|KIAA1549L_ENST00000389726.3_Silent_p.V20V					KIAA1549-like																		ATCTAGGTGTTTCTGGATCCT	0.493000													8	20					0	0	1	0	0
GPR39	2863	broad.mit.edu	37	2	133175423	133175423	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:133175423G>A	ENST00000329321.3	+	1	1277	c.808G>A	c.(808-810)Gag>Aag	p.E270K		NM_001508.2	NP_001499.1	O43194	GPR39_HUMAN	G protein-coupled receptor 39	270						integral to plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GAGGAAGTCCGAGAGCGAAGA	0.617000													15	79					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179659141	179659141	+	Silent	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:179659141T>C	ENST00000589042.1	-	8	1607	c.1383A>G	c.(1381-1383)caA>caG	p.Q461Q	TTN_ENST00000460472.2_Silent_p.Q461Q|TTN_ENST00000342175.6_Silent_p.Q461Q|TTN_ENST00000360870.5_Silent_p.Q461Q|TTN_ENST00000359218.5_Silent_p.Q461Q|TTN_ENST00000591111.1_Silent_p.Q461Q|TTN_ENST00000342992.6_Silent_p.Q461Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	461							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTGAGCAGGTTGGATGTGCA	0.557000													140	64					0	0	1	0	0
CORO7	79585	broad.mit.edu	37	16	4411249	4411249	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:4411249G>A	ENST00000251166.4	-	18	1833	c.1687_splice	c.e18-1	p.A563_splice	CORO7_ENST00000423908.2_3'UTR|CORO7_ENST00000537233.2_Splice_Site_p.A545_splice|CORO7_ENST00000574025.1_Splice_Site_p.A478_splice|CORO7_ENST00000539968.1_Splice_Site_p.A343_splice|CORO7-PAM16_ENST00000572467.1_Splice_Site_p.A563_splice	NM_024535.4	NP_078811.3			coronin 7											breast(3)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|prostate(2)|skin(2)|urinary_tract(2)	23						GTCCTCACCAGCTGCAGAGGA	0.657000													14	16					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73072090	73072090	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:73072090G>A	ENST00000429829.1	-	0	498					NR_001564.2																						ATGGGCTAAGGAAAAAAAAAT	0.468000													7	0					0	0	1	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65811070	65811070	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:65811070G>A	ENST00000312006.4	-	3	485	c.204C>T	c.(202-204)ttC>ttT	p.F68F	GAL3ST3_ENST00000527878.1_Silent_p.F68F	NM_033036.2	NP_149025.1	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	68					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			kidney(1)|lung(9)|ovary(2)|skin(2)	14						GAGTCTTCAGGAAGGCCACAG	0.657000													9	14					0	0	1	0	0
FUT3	2525	broad.mit.edu	37	19	5844504	5844504	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:5844504T>C	ENST00000303225.6	-	3	981	c.347A>G	c.(346-348)aAc>aGc	p.N116S	FUT3_ENST00000589620.1_Missense_Mutation_p.N116S|FUT3_ENST00000589918.1_Missense_Mutation_p.N116S|FUT3_ENST00000458379.2_Missense_Mutation_p.N116S	NM_000149.3	NP_000140.1	P21217	FUT3_HUMAN	fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)	116					protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(1)	14						TGACTTAGGGTTGGACATGAT	0.627000													48	38					0	0	1	0	0
P2RY12	64805	broad.mit.edu	37	3	151056103	151056103	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:151056103G>A	ENST00000302632.3	-	3	830	c.531C>T	c.(529-531)ttC>ttT	p.F177F	MED12L_ENST00000474524.1_Intron|MED12L_ENST00000491549.1_Intron|MED12L_ENST00000273432.4_Intron	NM_022788.4|NM_176876.2	NP_073625.1|NP_795345.1	Q9H244	P2Y12_HUMAN	purinergic receptor P2Y, G-protein coupled, 12	177					platelet activation	integral to membrane|plasma membrane	guanyl-nucleotide exchange factor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)	17			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)		Clopidogrel(DB00758)|Epoprostenol(DB01240)|Ticlopidine(DB00208)|Treprostinil(DB00374)	CTGATTTAAGGAAAGAGCATT	0.368000													36	30					0	0	1	0	0
PROM2	150696	broad.mit.edu	37	2	95947735	95947735	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:95947735G>A	ENST00000317620.9	+	13	1747	c.1614G>A	c.(1612-1614)agG>agA	p.R538R	PROM2_ENST00000542147.1_Silent_p.R538R|PROM2_ENST00000317668.4_Silent_p.R538R|PROM2_ENST00000403131.2_Silent_p.R538R	NM_001165978.1	NP_001159450.1	Q8N271	PROM2_HUMAN	prominin 2	538						apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	32						TTGGCCTGAGGAAGAACATCA	0.617000													12	65					0	0	1	0	0
LGSN	51557	broad.mit.edu	37	6	63990209	63990209	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:63990209G>A	ENST00000370657.4	-	4	1280	c.1247C>T	c.(1246-1248)cCt>cTt	p.P416L	LGSN_ENST00000370658.5_3'UTR			Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase domain	416					glutamine biosynthetic process		glutamate-ammonia ligase activity			NS(1)|endometrium(2)|large_intestine(5)|lung(16)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	34					L-Glutamic Acid(DB00142)	CACCAAGTAAGGGTTTGCTGT	0.448000													26	77					0	0	1	0	0
ACSM5	54988	broad.mit.edu	37	16	20422901	20422901	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:20422901C>T	ENST00000331849.4	+	2	242	c.95C>T	c.(94-96)cCt>cTt	p.P32L	ACSM5_ENST00000575584.1_Missense_Mutation_p.P32L	NM_017888.2	NP_060358.2	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	32					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(3)|urinary_tract(1)	51						CTACCTGTTCCTCAGAAGATC	0.577000													15	26					0	0	1	0	0
DBH	1621	broad.mit.edu	37	9	136513099	136513099	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:136513099C>T	ENST00000393056.2	+	6	1168	c.1156C>T	c.(1156-1158)Ctc>Ttc	p.L386F		NM_000787.3	NP_000778.3	P09172	DOPO_HUMAN	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	386					hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(9)|liver(1)|lung(6)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	36				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	CGCCTTCATCCTCACTGGCTA	0.657000													10	10					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	463569	463569	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:463569G>A	ENST00000432829.2	+	47	6233	c.5917G>A	c.(5917-5919)Gaa>Aaa	p.E1973K	DOCK8_ENST00000469391.1_Missense_Mutation_p.E1941K|RP11-165F24.3_ENST00000592805.1_RNA|RP11-165F24.3_ENST00000591577.1_RNA|RP11-165F24.3_ENST00000593137.1_RNA|RP11-165F24.3_ENST00000588474.1_RNA|DOCK8_ENST00000453981.1_Missense_Mutation_p.E2041K|RP11-165F24.3_ENST00000589387.1_RNA|RP11-165F24.3_ENST00000590518.1_RNA|RP11-165F24.3_ENST00000588989.1_RNA|RP11-165F24.3_ENST00000589287.1_RNA|DOCK8_ENST00000382329.1_Missense_Mutation_p.E1508K|RP11-165F24.3_ENST00000586805.1_RNA|RP11-165F24.3_ENST00000415004.2_RNA|RP11-165F24.3_ENST00000585819.1_RNA	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	2041					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		AGACCAGAGGGAATATCAGCA	0.413000													10	34					0	0	1	0	0
CNIH3	149111	broad.mit.edu	37	1	224868683	224868683	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:224868683G>A	ENST00000272133.3	+	2	987	c.105G>A	c.(103-105)agG>agA	p.R35R		NM_152495.1	NP_689708.1	Q8TBE1	CNIH3_HUMAN	cornichon family AMPA receptor auxiliary protein 3	35					intracellular signal transduction|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic shaft|postsynaptic membrane				large_intestine(5)|lung(4)	9	Breast(184;0.218)			GBM - Glioblastoma multiforme(131;0.073)		ATGAGTTAAGGACAGATTTTA	0.488000													63	30					0	0	1	0	0
GPRC6A	222545	broad.mit.edu	37	6	117127942	117127942	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:117127942G>A	ENST00000310357.3	-	3	947	c.926C>T	c.(925-927)aCc>aTc	p.T309I	GPRC6A_ENST00000368549.3_Missense_Mutation_p.T309I|GPRC6A_ENST00000530250.1_Intron	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	309					response to amino acid stimulus		G-protein coupled receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		GGTAATCTTGGTGGCAGTTGA	0.343000													11	46					0	0	1	0	0
OR4A16	81327	broad.mit.edu	37	11	55110948	55110948	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:55110948C>T	ENST00000314721.2	+	1	322	c.272C>T	c.(271-273)tCc>tTc	p.S91F		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	91					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						ATCGCTATTTCCTTGTCAGCT	0.438000													75	54					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28766121	28766121	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:28766121C>T	ENST00000422425.2	+	14	999	c.955C>T	c.(955-957)Ctc>Ttc	p.L319F	PLB1_ENST00000327757.5_Missense_Mutation_p.L308F	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	308	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					GGCCTGGCATCTCTGGAATAG	0.612000													13	4					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7584639	7584639	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:7584639G>A	ENST00000379802.3	+	24	7485	c.7144G>A	c.(7144-7146)Gag>Aag	p.E2382K	DSP_ENST00000418664.2_Missense_Mutation_p.E1783K	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2382	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TGACCCAAAGGAGAGCCATCG	0.448000													45	15					0	0	1	0	0
GMEB1	10691	broad.mit.edu	37	1	29030840	29030840	+	Splice_Site	SNP	A	A	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:29030840A>T	ENST00000373816.1	+	8	1005	c.868_splice	c.e8+1	p.T289_splice	GMEB1_ENST00000361872.4_Splice_Site_p.T289_splice|GMEB1_ENST00000294409.2_Splice_Site_p.T299_splice|GMEB1_ENST00000480454.1_3'UTR	NM_024482.2	NP_077808.1	Q9Y692	GMEB1_HUMAN	glucocorticoid modulatory element binding protein 1	299					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|metal ion binding|transcription coactivator activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)	11		Colorectal(325;3.46e-05)|Lung NSC(340;0.000451)|all_lung(284;0.00063)|Breast(348;0.00502)|Renal(390;0.00555)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		TCCAAGTCACAGGTAAGTGCA	0.468000													3	51					0	0	1	0	0
SH2D2A	9047	broad.mit.edu	37	1	156786498	156786498	+	Translation_Start_Site	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:156786498C>T	ENST00000392306.2	-	1	142	c.3G>A	c.(1-3)atG>atA	p.M1I	SH2D2A_ENST00000368199.3_Start_Codon_SNP_p.M1I|NTRK1_ENST00000392302.2_Intron|SH2D2A_ENST00000368198.3_5'UTR|SH2D2A_ENST00000495306.1_5'UTR	NM_001161441.1	NP_001154913.1	Q9NP31	SH22A_HUMAN	SH2 domain containing 2A	1					angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity			endometrium(1)|large_intestine(2)|lung(15)	18	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GGGGGAACTCCATGAGGGCAG	0.582000													8	58					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96773201	96773201	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:96773201G>A	ENST00000359933.4	-	30	5249	c.4356C>T	c.(4354-4356)ttC>ttT	p.F1452F	ATG2B_ENST00000261834.5_5'UTR	NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	1452										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		CAGGAAACAGGAAGAGGTCTG	0.433000													17	11					0	0	1	0	0
TMEM132D	121256	broad.mit.edu	37	12	129566552	129566552	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:129566552C>T	ENST00000422113.2	-	7	2001	c.1675G>A	c.(1675-1677)Gag>Aag	p.E559K	TMEM132D_ENST00000389441.4_Missense_Mutation_p.E97K	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	559						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TCATCATCCTCCTCCTCTTCA	0.642000													13	45					0	0	1	0	0
C5orf20	140947	broad.mit.edu	37	5	134782469	134782469	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:134782469C>T	ENST00000503143.2	-	1	569	c.330G>A	c.(328-330)caG>caA	p.Q110Q	TIFAB_ENST00000537858.1_3'UTR	NM_130848.2	NP_570900.1	Q8TF63	DCNP1_HUMAN	chromosome 5 open reading frame 20	110						nucleus				endometrium(1)|lung(1)|prostate(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GCAGTTCATCCTGGGTCCCTG	0.572000													50	18					0	0	1	0	0
AADACL4	343066	broad.mit.edu	37	1	12711223	12711223	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:12711223G>A	ENST00000376221.1	+	2	250	c.250G>A	c.(250-252)Gac>Aac	p.D84N		NM_001013630.1	NP_001013652.1	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	84						integral to membrane	carboxylesterase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)	17	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		AATTAAAAAGGACCCTGAACT	0.483000													15	108					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32774474	32774474	+	Missense_Mutation	SNP	C	C	T	rs11540648		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:32774474C>T	ENST00000421745.2	+	65	13204	c.13070C>T	c.(13069-13071)cCt>cTt	p.P4357L		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	4357					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					AATGCCCTTCCTTCTGTACTT	0.443000													32	47					0	0	1	0	0
PRRX1	5396	broad.mit.edu	37	1	170699465	170699465	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:170699465G>A	ENST00000367760.3	+	4	1732	c.647G>A	c.(646-648)gGa>gAa	p.G216E	PRRX1_ENST00000239461.6_Intron|PRRX1_ENST00000476867.2_Intron	NM_006902.3	NP_008833.1	P54821	PRRX1_HUMAN	paired related homeobox 1	0						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			large_intestine(2)|ovary(1)	3	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CTTCATAACGGATTCTAACGG	0.453000													31	177					0	0	1	0	0
ZNF573	126231	broad.mit.edu	37	19	38262267	38262267	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:38262267G>A	ENST00000590414.2	-	2	160	c.139C>T	c.(139-141)Cct>Tct	p.P47S	ZNF573_ENST00000536220.1_5'UTR|ZNF573_ENST00000357309.3_Intron|ZNF573_ENST00000339503.4_5'UTR|ZNF573_ENST00000585724.1_Intron|ZNF573_ENST00000392138.1_5'UTR			Q86YE8	ZN573_HUMAN	zinc finger protein 573	27	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(3)|endometrium(2)|large_intestine(8)|liver(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			CTCTGATTAGGGTCCAGGTAT	0.403000													9	18					0	0	1	0	0
ZNF662	389114	broad.mit.edu	37	3	42956430	42956430	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:42956430A>C	ENST00000541208.1	+	5	1234	c.865A>C	c.(865-867)Aca>Cca	p.T289P	ZNF662_ENST00000422021.1_Intron|ZNF662_ENST00000440367.2_Missense_Mutation_p.T289P|ZNF662_ENST00000328199.6_Missense_Mutation_p.T315P|KRBOX1_ENST00000426937.1_Intron			Q6ZS27	ZN662_HUMAN	zinc finger protein 662	289					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|large_intestine(6)|lung(5)|upper_aerodigestive_tract(1)	15				KIRC - Kidney renal clear cell carcinoma(284;0.217)		TAGTCAGAACACAAGCCTTAC	0.453000													5	22					0	0	1	0	0
LOC645752	645752	broad.mit.edu	37	15	78211645	78211645	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr15:78211645G>A	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							GGGCGCCAGGGATAGGGGCTC	0.522000													34	3					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	180017711	180017711	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:180017711C>T	ENST00000367607.3	+	22	5081	c.4663C>T	c.(4663-4665)Cca>Tca	p.P1555S		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	1555	Ser-rich.					centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						TCCTTCAGTTCCATCTTGTAA	0.373000													31	12					0	0	1	0	0
RHPN2	85415	broad.mit.edu	37	19	33499063	33499063	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:33499063G>A	ENST00000254260.3	-	7	652	c.617C>T	c.(616-618)cCg>cTg	p.P206L	RHPN2_ENST00000400226.4_Missense_Mutation_p.P55L	NM_033103.4	NP_149094.3	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	206	BRO1.				signal transduction	perinuclear region of cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(5)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(3)|skin(3)|urinary_tract(1)	44	Esophageal squamous(110;0.137)					CTGGCTGACCGGAACCCCGGT	0.498000													6	11					0	0	1	0	0
TAOK2	9344	broad.mit.edu	37	16	29996879	29996879	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:29996879C>T	ENST00000308893.4	+	14	2811	c.1768C>T	c.(1768-1770)Cgc>Tgc	p.R590C	TAOK2_ENST00000279394.3_Missense_Mutation_p.R590C|TAOK2_ENST00000543033.1_Missense_Mutation_p.R590C|TAOK2_ENST00000416441.2_Missense_Mutation_p.R417C	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	590					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						CTACAAACTTCGCAAGGAACA	0.642000													14	27					0	0	1	0	0
NXPE2	120406	broad.mit.edu	37	11	114568828	114568828	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:114568828C>T	ENST00000375475.5	+	3	292	c.194C>T	c.(193-195)tCa>tTa	p.S65L	NXPE2_ENST00000389586.4_Missense_Mutation_p.S65L					neurexophilin and PC-esterase domain family, member 2																		AAAAAATATTCACACTCTGAA	0.378000													6	8					0	0	1	0	0
GBF1	8729	broad.mit.edu	37	10	104130480	104130480	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:104130480G>A	ENST00000369983.3	+	29	3780	c.3520G>A	c.(3520-3522)Gtg>Atg	p.V1174M		NM_001199378.1|NM_001199379.1|NM_004193.2	NP_001186307.1|NP_001186308.1|NP_004184.1	Q92538	GBF1_HUMAN	golgi brefeldin A resistant guanine nucleotide exchange factor 1	1174					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(14)|kidney(8)|large_intestine(15)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	71		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		TGTGGGCTGTGTGTGGCAGAC	0.552000													58	14					0	0	1	0	0
SMPDL3B	27293	broad.mit.edu	37	1	28285118	28285118	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:28285118G>A	ENST00000373894.3	+	8	1328	c.1137G>A	c.(1135-1137)ctG>ctA	p.L379L	RP11-460I13.2_ENST00000448015.1_RNA|SMPDL3B_ENST00000549094.1_Silent_p.L331L	NM_014474.2	NP_055289.2	Q92485	ASM3B_HUMAN	sphingomyelin phosphodiesterase, acid-like 3B	379					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	16		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000431)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;5.68e-24)|Colorectal(126;1.65e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00587)|READ - Rectum adenocarcinoma(331;0.055)		ACACAGTGCTGGACCGCATCG	0.647000													93	28					0	0	1	0	0
DBX2	440097	broad.mit.edu	37	12	45417512	45417512	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:45417512T>C	ENST00000332700.6	-	3	836	c.665A>G	c.(664-666)aAc>aGc	p.N222S		NM_001004329.2	NP_001004329.2	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	222						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	22	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		TAGTCCCAAGTTGATGGCAAG	0.413000													57	141					0	0	1	0	0
NUGGC	389643	broad.mit.edu	37	8	27880848	27880848	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:27880848C>G	ENST00000413272.2	-	19	2519	c.2377G>C	c.(2377-2379)Ggg>Cgg	p.G793R	NUGGC_ENST00000341513.6_Missense_Mutation_p.G793R	NM_001010906.1	NP_001010906.1			nuclear GTPase, germinal center associated																		AGTGATGTCCCGGGGGGGCCA	0.527000													16	13					0	0	1	0	0
LGALS12	85329	broad.mit.edu	37	11	63283158	63283158	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:63283158C>T	ENST00000415491.2	+	7	1268	c.654C>T	c.(652-654)ttC>ttT	p.F218F	LGALS12_ENST00000425950.2_Silent_p.F209F|LGALS12_ENST00000255684.5_Silent_p.F270F|LGALS12_ENST00000394618.3_Silent_p.F279F|LGALS12_ENST00000340246.5_Silent_p.F280F	NM_001142537.1	NP_001136009.1	Q96DT0	LEG12_HUMAN	lectin, galactoside-binding, soluble, 12	279	Galectin 2.				apoptosis|induction of apoptosis by intracellular signals	nucleus	lactose binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	16						CAGCCCCCTTCCTCTTTTACC	0.552000													4	20					0	0	1	0	0
CA6	765	broad.mit.edu	37	1	9031030	9031030	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:9031030C>T	ENST00000377443.2	+	7	838	c.834C>T	c.(832-834)ttC>ttT	p.F278F	CA6_ENST00000476083.1_3'UTR|CA6_ENST00000377442.2_Silent_p.F218F|CA6_ENST00000377436.3_Silent_p.F278F	NM_001215.3	NP_001206.2	P23280	CAH6_HUMAN	carbonic anhydrase VI	278					one-carbon metabolic process	extracellular region	carbonate dehydratase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|skin(5)	16	Ovarian(185;0.112)|all_lung(157;0.143)	all_epithelial(116;1.02e-19)|all_lung(118;3.6e-06)|Lung NSC(185;7.94e-06)|Renal(390;0.000147)|Breast(348;0.00123)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.9e-07)|COAD - Colon adenocarcinoma(227;8.28e-05)|Kidney(185;0.000268)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|STAD - Stomach adenocarcinoma(132;0.00184)|BRCA - Breast invasive adenocarcinoma(304;0.00192)|READ - Rectum adenocarcinoma(331;0.0649)		AATCCAACTTCCCGAATCAGG	0.507000													16	80					0	0	1	0	0
ACOX3	8310	broad.mit.edu	37	4	8416601	8416601	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:8416601G>A	ENST00000356406.5	-	4	510	c.433C>T	c.(433-435)Caa>Taa	p.Q145*	ACOX3_ENST00000503233.1_Nonsense_Mutation_p.Q145*|ACOX3_ENST00000413009.2_Nonsense_Mutation_p.Q145*	NM_003501.2	NP_003492.2	O15254	ACOX3_HUMAN	acyl-CoA oxidase 3, pristanoyl	145					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(9)|lung(17)|prostate(1)|skin(3)|stomach(1)	42						AAGATCTTTTGAATATATGTG	0.398000													28	24					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179443758	179443758	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:179443758G>A	ENST00000589042.1	-	320	68223	c.67999C>T	c.(67999-68001)Cct>Tct	p.P22667S	TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.P13602S|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.P13794S|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.P13727S|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P21026S|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000456053.1_RNA|RP11-171I2.2_ENST00000603521.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.P20099S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	21026	Fibronectin type-III 64.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCTTTGGAGGAGCCCACTTT	0.478000													27	19					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152514605	152514605	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:152514605C>T	ENST00000427231.2	-	48	6278		c.e48-1		NEB_ENST00000409198.1_Splice_Site|NEB_ENST00000603639.1_Splice_Site|NEB_ENST00000397345.3_Splice_Site|NEB_ENST00000604864.1_Splice_Site|NEB_ENST00000172853.10_Splice_Site	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin						muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TGTAGAGTTTCTGTAAAGAGA	0.368000													4	7					0	0	1	0	0
BICD2	23299	broad.mit.edu	37	9	95481455	95481455	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:95481455G>A	ENST00000356884.6	-	5	1539	c.1472C>T	c.(1471-1473)gCc>gTc	p.A491V	BICD2_ENST00000375512.3_Missense_Mutation_p.A491V	NM_001003800.1	NP_001003800.1	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 (Drosophila)	491					microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			cervix(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23						CTGGCGGCTGGCCTTCTCTAG	0.677000													42	32					0	0	1	0	0
GLDC	2731	broad.mit.edu	37	9	6558609	6558609	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:6558609C>A	ENST00000321612.6	-	17	2152	c.2002G>T	c.(2002-2004)Gtg>Ttg	p.V668L	GLDC_ENST00000460457.1_5'UTR	NM_000170.2	NP_000161.2	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	668					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	TCCACCTCCACAGGCTGAATC	0.507000													64	67					1.12612e-26	1.14855e-26	1	1	0
OGG1	4968	broad.mit.edu	37	3	9793535	9793535	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:9793535C>T	ENST00000302036.7	+	3	810	c.467C>T	c.(466-468)aCt>aTt	p.T156I	OGG1_ENST00000302003.7_Missense_Mutation_p.T156I|OGG1_ENST00000339511.5_Missense_Mutation_p.T156I|OGG1_ENST00000344629.7_Missense_Mutation_p.T156I|OGG1_ENST00000383826.5_Missense_Mutation_p.T156I|OGG1_ENST00000302008.8_Missense_Mutation_p.T156I|OGG1_ENST00000449570.2_Missense_Mutation_p.T156I|OGG1_ENST00000349503.5_Missense_Mutation_p.T156I	NM_016821.2	NP_058214.1	O15527	OGG1_HUMAN	8-oxoguanine DNA glycosylase	156					depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding			kidney(2)|large_intestine(2)|lung(2)|skin(1)|urinary_tract(1)	8	Medulloblastoma(99;0.227)					GCCCGCATCACTGGCATGGTG	0.567000								Base excision repair (BER), DNA glycosylases					65	46					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54806647	54806647	+	Missense_Mutation	SNP	C	C	T	rs145623856		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:54806647C>T	ENST00000306858.7	+	5	2994	c.2878C>T	c.(2878-2880)Cgc>Tgc	p.R960C		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	960								p.R960C(1)		autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					CAGTATAAATCGCCCAGAAAT	0.413000													5	39					0	0	1	0	0
OR4D5	219875	broad.mit.edu	37	11	123810636	123810636	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:123810636C>T	ENST00000307033.2	+	1	387	c.313C>T	c.(313-315)Cac>Tac	p.H105Y		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	105					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CTTCTTCTTCCACTTCATTGG	0.493000													35	30					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39013705	39013705	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:39013705G>A	ENST00000355481.4	+	68	10428	c.10297G>A	c.(10297-10299)Gag>Aag	p.E3433K	RYR1_ENST00000359596.3_Missense_Mutation_p.E3433K|RYR1_ENST00000360985.3_Missense_Mutation_p.E3433K	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3433					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CAGCGCGGAGGAGCTGTTCAG	0.682000													12	24					0	0	1	0	0
SH2B3	10019	broad.mit.edu	37	12	111855963	111855963	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:111855963C>T	ENST00000341259.2	+	2	371	c.14C>T	c.(13-15)gCc>gTc	p.A5V		NM_005475.2	NP_005466.1	Q9UQQ2	SH2B3_HUMAN	SH2B adaptor protein 3	5					blood coagulation	cytosol	signal transducer activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	10						AACGGGCCTGCCCTGCAGCCC	0.721000													19	18					0	0	1	0	0
ADAM32	203102	broad.mit.edu	37	8	39114840	39114840	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:39114840G>A	ENST00000379907.4	+	19	2267	c.2140G>A	c.(2140-2142)Gaa>Aaa	p.E714K	ADAM32_ENST00000519315.1_Missense_Mutation_p.E608K|ADAM32_ENST00000437682.2_Missense_Mutation_p.E615K	NM_145004.5	NP_659441.3	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	714					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			GTTCGCCAAGGAAGAGGAATT	0.383000													36	38					0	0	1	0	0
LRRC1	55227	broad.mit.edu	37	6	53769222	53769222	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:53769222A>C	ENST00000370888.1	+	10	1229	c.952A>C	c.(952-954)Aat>Cat	p.N318H		NM_018214.4	NP_060684.4	Q9BTT6	LRRC1_HUMAN	leucine rich repeat containing 1	318						cytoplasm|membrane				cervix(1)|endometrium(3)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)		GAGCAACTTGAATGCAGACAG	0.294000													26	14					0	0	1	0	0
COX15	1355	broad.mit.edu	37	10	101486875	101486875	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:101486875G>A	ENST00000370483.5	-	4	482	c.432C>T	c.(430-432)ttC>ttT	p.F144F	COX15_ENST00000016171.5_Silent_p.F144F|CUTC_ENST00000493385.1_Intron	NM_004376.5|NM_078470.4	NP_004367.2|NP_510870.1	Q7KZN9	COX15_HUMAN	cytochrome c oxidase assembly homolog 15 (yeast)	144					heme a biosynthetic process|respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13		Colorectal(252;0.234)		Epithelial(162;3.08e-10)|all cancers(201;2.43e-08)		TGTACCAGATGAACTTGAATT	0.453000													13	2					0	0	1	0	0
NTN4	59277	broad.mit.edu	37	12	96104369	96104369	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:96104369C>T	ENST00000343702.4	-	5	1478	c.1030G>A	c.(1030-1032)Gac>Aac	p.D344N	NTN4_ENST00000344911.4_Missense_Mutation_p.D307N|NTN4_ENST00000553059.1_Missense_Mutation_p.D344N|NTN4_ENST00000538383.1_Missense_Mutation_p.D307N	NM_021229.3	NP_067052.2	Q9HB63	NET4_HUMAN	netrin 4	344	Laminin EGF-like 2.				axon guidance	basement membrane|plasma membrane				NS(2)|breast(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						ACATTAACGTCGAAGTGACAG	0.458000													7	36					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83643565	83643565	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:83643565G>A	ENST00000265362.3	-	7	1084	c.770C>T	c.(769-771)tCt>tTt	p.S257F	SEMA3A_ENST00000436949.1_Missense_Mutation_p.S257F	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	257	Sema.				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						AGCTTTTCCAGAGTGTTCTCC	0.388000													27	29					0	0	1	0	0
OR13A1	79290	broad.mit.edu	37	10	45799184	45799184	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:45799184G>A	ENST00000553795.1	-	4	995	c.687C>T	c.(685-687)ttC>ttT	p.F229F	OR13A1_ENST00000374401.2_Silent_p.F229F|OR13A1_ENST00000536058.1_Silent_p.F229F	NM_001004297.2	NP_001004297.2	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A, member 1	229					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(2)|urinary_tract(1)	19						TGGTCATCAGGAAGTTCACTA	0.572000													39	12					0	0	1	0	0
PLAG1	5324	broad.mit.edu	37	8	57079014	57079014	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:57079014G>A	ENST00000316981.3	-	5	1770	c.1291C>T	c.(1291-1293)Ccc>Tcc	p.P431S	PLAG1_ENST00000423799.2_Missense_Mutation_p.P349S|PLAG1_ENST00000429357.2_Missense_Mutation_p.P431S	NM_001114634.1|NM_002655.2	NP_001108106.1|NP_002646.2	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1	431	Activates transcription; Inhibition of nuclear import due to lack of NLS and KPNA2 interaction.|Massively activates transcription.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|FGFR1_ENST00000447712/PLAG1(28)|COL1A2/PLAG1(3)|CHCHD7/PLAG1(12)|TCEA1_ENST00000521604/PLAG1(3)	breast(3)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(7)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			GGATTATAGGGAGGACCATTT	0.453000			T	"""TCEA1, LIFR, CTNNB1, CHCHD7"""	salivary adenoma								28	46					0	0	1	0	0
ZNF793	390927	broad.mit.edu	37	19	38028572	38028572	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:38028572C>T	ENST00000445217.1	+	4	1047	c.1012C>T	c.(1012-1014)Ccg>Tcg	p.P338S	ZNF793_ENST00000542455.1_Missense_Mutation_p.P338S|ZNF793_ENST00000588578.1_3'UTR|ZNF793_ENST00000589319.1_Intron|ZNF793_ENST00000587143.1_Missense_Mutation_p.P338S			Q6ZN11	ZN793_HUMAN	zinc finger protein 793	338					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(2)|lung(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGGAGAAAGACCGTATCGTTG	0.458000													17	18					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78848477	78848477	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:78848477G>A	ENST00000545128.1	+	22	3369	c.2831G>A	c.(2830-2832)gGa>gAa	p.G944E		NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	647					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						AGATGCCAAGGAAGTGGCCCT	0.527000													20	51					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56403074	56403074	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:56403074C>T	ENST00000355701.3	-	4	1441	c.570_splice	c.e4-1	p.V191_splice	BZRAP1_ENST00000343736.4_Splice_Site_p.V191_splice|BZRAP1_ENST00000268893.6_Intron|BZRAP1-AS1_ENST00000579527.1_RNA	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	191						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGGGCACTCACCTAGCCAGAG	0.632000													17	17					0	0	1	0	0
BICD1	636	broad.mit.edu	37	12	32481286	32481286	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:32481286C>T	ENST00000548411.1	+	5	2078	c.1897C>T	c.(1897-1899)Cgg>Tgg	p.R633W	BICD1_ENST00000281474.5_Missense_Mutation_p.R633W	NM_001003398.1	NP_001003398.1	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 (Drosophila)	633					anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			NS(1)|breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			TGCCATAATCCGGGACCAAAT	0.483000													43	40					0	0	1	0	0
RHO	6010	broad.mit.edu	37	3	129251202	129251202	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:129251202C>T	ENST00000296271.3	+	3	733	c.639C>T	c.(637-639)acC>acT	p.T213T		NM_000539.3	NP_000530.1	P08100	OPSD_HUMAN	rhodopsin	213					protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding			breast(1)|endometrium(1)|large_intestine(10)|lung(6)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	22		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	TCCACTTCACCATCCCCATGA	0.572000													28	59					0	0	1	0	0
CDH22	64405	broad.mit.edu	37	20	44869733	44869733	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:44869733C>T	ENST00000372262.3	-	2	819	c.419G>A	c.(418-420)cGg>cAg	p.R140Q	CDH22_ENST00000537909.1_Missense_Mutation_p.R140Q	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	140	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				GGCGCGATCCCGAGCCTGGGC	0.617000													80	38					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41049521	41049521	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:41049521G>A	ENST00000399564.4	-	14	1812	c.1362C>T	c.(1360-1362)atC>atT	p.I454I	MROH2B_ENST00000506092.2_Silent_p.I9I	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		CAAAAGTCAGGATCCTTGGCC	0.453000													20	2					0	0	1	0	0
IMP4	92856	broad.mit.edu	37	2	131103602	131103602	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:131103602C>T	ENST00000259239.3	+	7	1314	c.606C>T	c.(604-606)atC>atT	p.I202I	IMP4_ENST00000409935.1_Silent_p.I202I	NM_033416.1	NP_219484.1	Q96G21	IMP4_HUMAN	IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)	202	Brix.				rRNA processing|translation	nucleolus|ribonucleoprotein complex	aminoacyl-tRNA ligase activity|ATP binding|protein binding			central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|skin(1)|urinary_tract(1)	18	Colorectal(110;0.1)					TCTCTGACATCCTCCGATACC	0.597000													33	53					0	0	1	0	0
CYP2B6	1555	broad.mit.edu	37	19	41497264	41497264	+	Silent	SNP	C	C	T	rs150742423	byFrequency	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:41497264C>T	ENST00000324071.4	+	1	61	c.54C>T	c.(52-54)ctC>ctT	p.L18L		NM_000767.4	NP_000758.1	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B, polypeptide 6	18					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	TCTTGCTACTCCTGGTTCAGC	0.612000													143	114					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231102934	231102934	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:231102934C>T	ENST00000392045.3	+	3	358	c.244C>T	c.(244-246)Caa>Taa	p.Q82*	SP140_ENST00000417495.3_Nonsense_Mutation_p.Q82*|SP140_ENST00000343805.6_Nonsense_Mutation_p.Q82*|SP140_ENST00000544128.1_3'UTR|SP140_ENST00000373645.3_Nonsense_Mutation_p.Q82*|SP140_ENST00000350136.5_Nonsense_Mutation_p.Q62*|SP140_ENST00000486687.2_Nonsense_Mutation_p.Q82*|SP140_ENST00000420434.3_Nonsense_Mutation_p.Q82*	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	82	HSR.				defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TAAGCATTTTCAAGAAGCTTT	0.358000													7	62					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41759578	41759578	+	Silent	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:41759578A>G	ENST00000301178.4	+	17	2191	c.2001A>G	c.(1999-2001)agA>agG	p.R667R	AXL_ENST00000593513.1_Silent_p.R399R|AXL_ENST00000359092.3_Silent_p.R658R	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	667	Protein kinase.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						GTACCAAGAGATTCATACACC	0.602000													6	9					0	0	1	0	0
ZER1	10444	broad.mit.edu	37	9	131515760	131515760	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:131515760G>A	ENST00000291900.2	-	4	835	c.429C>T	c.(427-429)ttC>ttT	p.F143F	ZER1_ENST00000494461.1_5'UTR	NM_006336.2	NP_006327.2	Q7Z7L7	ZER1_HUMAN	zyg-11 related, cell cycle regulator	143					ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			endometrium(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	15						CCTCCTCATAGAAAATGTTTG	0.562000													22	12					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74466470	74466470	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:74466470G>A	ENST00000394019.2	-	21	2708	c.2311C>T	c.(2311-2313)Cct>Tct	p.P771S	SLC4A5_ENST00000423644.1_Missense_Mutation_p.P771S|SLC4A5_ENST00000377632.1_Missense_Mutation_p.P771S|SLC4A5_ENST00000377634.4_Missense_Mutation_p.P771S|SLC4A5_ENST00000359484.4_Missense_Mutation_p.P707S|SLC4A5_ENST00000357822.5_Missense_Mutation_p.P771S|SLC4A5_ENST00000346834.4_Missense_Mutation_p.P771S|SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000358683.4_Missense_Mutation_p.P707S|RP11-287D1.3_ENST00000451608.2_3'UTR	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	771						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						ACCTTGGTAGGAAAATAGCGG	0.532000													4	30					0	0	1	0	0
KRTAP10-4	386672	broad.mit.edu	37	21	45994516	45994516	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr21:45994516C>T	ENST00000400374.3	+	1	911	c.881C>T	c.(880-882)tCc>tTc	p.S294F	TSPEAR_ENST00000323084.4_Intron	NM_198687.1	NP_941960.1	P60372	KR104_HUMAN	keratin associated protein 10-4	294	36 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(1)	18						TCTGGGGCTTCCTCTCTGTGC	0.642000													44	102					0	0	1	0	0
MAATS1	89876	broad.mit.edu	37	3	119452210	119452210	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:119452210G>A	ENST00000273390.5	+	10	1278		c.e10-1			NM_033364.3	NP_203528.2			MYCBP-associated, testis expressed 1																		CCTTCCCATAGGATTAGTGGA	0.373000													11	31					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3226873	3226873	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:3226873G>A	ENST00000602557.1	-	20	3360	c.2805C>T	c.(2803-2805)atC>atT	p.I935I	CSMD1_ENST00000400186.3_Silent_p.I935I|CSMD1_ENST00000542608.1_Silent_p.I934I|CSMD1_ENST00000539096.1_Silent_p.I934I|CSMD1_ENST00000602723.1_Silent_p.I935I|CSMD1_ENST00000537824.1_Silent_p.I934I|CSMD1_ENST00000520002.1_Silent_p.I935I			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	935	CUB 6.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCTTCCCTTGGATGTAGCCTC	0.403000													3	6					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56223859	56223859	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:56223859C>T	ENST00000332836.2	-	7	2626	c.2599G>A	c.(2599-2601)Gaa>Aaa	p.E867K		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	867						cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		TCTCCTATTTCATTATGCCCA	0.448000													13	31					0	0	1	0	0
TAS2R39	259285	broad.mit.edu	37	7	142880740	142880740	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:142880740G>A	ENST00000446620.1	+	1	229	c.229G>A	c.(229-231)Gtt>Att	p.V77I		NM_176881.2	NP_795362.2	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	77					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	Melanoma(164;0.059)					CAGGATCCTGGTTTTCCTGAG	0.408000													32	39					0	0	1	0	0
USP20	10868	broad.mit.edu	37	9	132627616	132627616	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:132627616G>A	ENST00000315480.4	+	10	804	c.646G>A	c.(646-648)Ggg>Agg	p.G216R	USP20_ENST00000372429.3_Missense_Mutation_p.G216R|USP20_ENST00000358355.1_Missense_Mutation_p.G216R			Q9Y2K6	UBP20_HUMAN	ubiquitin specific peptidase 20	216					endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|urinary_tract(1)	11		Ovarian(14;0.00556)				TCTGTCTCATGGGATCAAGTT	0.582000													28	24					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90501248	90501248	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:90501248C>T	ENST00000325643.5	+	4	1912	c.1846C>T	c.(1846-1848)Ccc>Tcc	p.P616S		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		CCCCATCCTTCCCGGGGTTGT	0.632000													27	39					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39358914	39358914	+	Silent	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:39358914T>C	ENST00000280481.7	+	6	6204	c.5988T>C	c.(5986-5988)gcT>gcC	p.A1996A		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1996					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TCCCAGGGGCTCAAGTTACAA	0.438000													22	23					0	0	1	0	0
DMBX1	127343	broad.mit.edu	37	1	46977893	46977893	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:46977893C>T	ENST00000371956.4	+	4	891	c.876C>T	c.(874-876)gcC>gcT	p.A292A	DMBX1_ENST00000360032.3_Silent_p.A287A	NM_147192.2	NP_671725.1	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1	292					brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Acute lymphoblastic leukemia(166;0.155)					GGGGTCCGGCCCCTGCTGCTG	0.657000													56	26					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104432834	104432834	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:104432834G>A	ENST00000361820.3	-	3	2460	c.1860C>T	c.(1858-1860)ctC>ctT	p.L620L		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	620					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TCCCTCTCAGGAGATCACCCA	0.498000													11	32					0	0	1	0	0
RECQL4	9401	broad.mit.edu	37	8	145738662	145738662	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:145738662G>A	ENST00000428558.2	-	15	2443	c.2402C>T	c.(2401-2403)gCc>gTc	p.A801V	CTD-2517M22.17_ENST00000580385.1_RNA|RECQL4_ENST00000532237.1_5'UTR	NM_004260.3	NP_004251.3	O94761	RECQ4_HUMAN	RecQ protein-like 4	801	Helicase C-terminal.				DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	26	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CCGGCCCACGGCCTGCACGTA	0.721000			"""N, F, S"""			"""osteosarcoma, skin basal and sqamous cell"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Rothmund-Thomson syndrome;RAPADILINO syndrome;Baller-Gerold syndrome				13	14					0	0	1	0	0
CLN5	1203	broad.mit.edu	37	13	77570096	77570096	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:77570096G>A	ENST00000377453.3	+	3	1838	c.546G>A	c.(544-546)atG>atA	p.M182I	CLN5_ENST00000485938.1_3'UTR	NM_006493.2	NP_006484.1	O75503	CLN5_HUMAN	ceroid-lipofuscinosis, neuronal 5	133					brain development|cell death|lysosomal lumen acidification|neuron maturation|protein catabolic process	endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	16		Acute lymphoblastic leukemia(28;0.205)		GBM - Glioblastoma multiforme(99;0.0503)		ACTACACAATGGAATGGTATG	0.413000													55	59					0	0	1	0	0
CPPED1	55313	broad.mit.edu	37	16	12758944	12758944	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:12758944G>A	ENST00000381774.4	-	4	984	c.744C>T	c.(742-744)taC>taT	p.Y248Y	CPPED1_ENST00000261660.4_Intron|CPPED1_ENST00000433677.2_Silent_p.Y106Y	NM_018340.2	NP_060810.2	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain containing 1	248							hydrolase activity|metal ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|skin(1)|urinary_tract(1)	18						CATTCCTGTGGTAGTGGCCTG	0.562000													26	24					0	0	1	0	0
MTIF2	4528	broad.mit.edu	37	2	55481241	55481241	+	Silent	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:55481241A>G	ENST00000394600.3	-	8	1336	c.600T>C	c.(598-600)ttT>ttC	p.F200F	MTIF2_ENST00000403721.1_Silent_p.F200F|MTIF2_ENST00000263629.4_Silent_p.F200F	NM_001005369.1	NP_001005369.1	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	200	G-domain.				regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	24						GAGTTTTTCGAAATTTGTCAA	0.453000													11	55					0	0	1	0	0
GBA3	57733	broad.mit.edu	37	4	22820418	22820418	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:22820418G>A	ENST00000503442.1	+	0	452				GBA3_ENST00000508264.1_RNA|GBA3_ENST00000511446.1_RNA|GBA3_ENST00000508166.1_RNA	NM_001128432.2	NP_001121904.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						GTGGAACCAGGGATACAGCAG	0.418000													10	13					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50532585	50532585	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:50532585C>T	ENST00000374144.3	+	3	2283	c.1995C>T	c.(1993-1995)acC>acT	p.T665T	C10orf71_ENST00000323868.4_Silent_p.T665T			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	665										endometrium(1)	1						AAATGAAGACCCACCAGCTAG	0.532000													20	4					0	0	1	0	0
MTUS1	57509	broad.mit.edu	37	8	17581312	17581312	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:17581312G>A	ENST00000262102.6	-	4	2542	c.2318C>T	c.(2317-2319)tCg>tTg	p.S773L	MTUS1_ENST00000381869.3_Intron|MTUS1_ENST00000519263.1_Intron	NM_001001924.2	NP_001001924.1	Q9ULD2	MTUS1_HUMAN	microtubule associated tumor suppressor 1	773						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(14)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	36				Colorectal(111;0.0778)		CACCCATGACGACTGTGCAGT	0.463000													38	71					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76499012	76499012	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:76499012C>T	ENST00000389840.5	-	32	5150	c.5026G>A	c.(5026-5028)Gaa>Aaa	p.E1676K	DNAH17-AS1_ENST00000598378.1_3'UTR|DNAH17_ENST00000585328.1_Missense_Mutation_p.E1677K					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GGCTTCTCTTCGTAGGTCACC	0.647000													25	3					0	0	1	0	0
ABLIM2	84448	broad.mit.edu	37	4	8055966	8055966	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:8055966G>A	ENST00000318888.4	-	8	913	c.42C>T	c.(40-42)tcC>tcT	p.S14S	ABLIM2_ENST00000341937.5_Silent_p.S257S|ABLIM2_ENST00000428004.2_Silent_p.S257S|ABLIM2_ENST00000505872.1_Silent_p.S257S|ABLIM2_ENST00000407564.3_Silent_p.S257S|ABLIM2_ENST00000545242.1_Silent_p.S257S|ABLIM2_ENST00000361581.5_Silent_p.S257S|ABLIM2_ENST00000514025.1_Silent_p.S14S|ABLIM2_ENST00000447017.2_Silent_p.S257S|ABLIM2_ENST00000296372.8_Silent_p.S257S|ABLIM2_ENST00000546334.1_Silent_p.S257S|ABLIM2_ENST00000361737.5_Silent_p.S257S			Q6H8Q1	ABLM2_HUMAN	actin binding LIM protein family, member 2	257					axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|pancreas(3)|prostate(2)|urinary_tract(1)	25						GATGCCAGATGGAGGAACCTG	0.522000													8	21					0	0	1	0	0
RB1	5925	broad.mit.edu	37	13	48955570	48955570	+	Silent	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:48955570A>G	ENST00000267163.4	+	17	1824	c.1686A>G	c.(1684-1686)gcA>gcG	p.A562A		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	562	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(8)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AATCCCTTGCATGGCTCTCAG	0.343000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			6	10					0	0	1	0	0
TMCC1	23023	broad.mit.edu	37	3	129389629	129389629	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:129389629G>A	ENST00000393238.3	-	4	1395	c.1055C>T	c.(1054-1056)tCc>tTc	p.S352F	TMCC1_ENST00000432054.2_Missense_Mutation_p.S28F|TMCC1_ENST00000329333.5_Missense_Mutation_p.S173F|TMCC1_ENST00000426664.2_Missense_Mutation_p.S238F	NM_001017395.3	NP_001017395.2	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	352						integral to membrane			PLXND1/TMCC1(4)	breast(1)|endometrium(3)|large_intestine(8)|lung(12)|skin(1)	25						GGAGAAGCTGGAAAACCCACC	0.522000													23	34					0	0	1	0	0
SNX20	124460	broad.mit.edu	37	16	50707697	50707697	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:50707697C>T	ENST00000330943.4	-	4	742	c.571G>A	c.(571-573)Gag>Aag	p.E191K	SNX20_ENST00000300590.3_Intron|SNX20_ENST00000423026.2_Intron	NM_182854.2	NP_878274.1	Q7Z614	SNX20_HUMAN	sorting nexin 20	191	PX.				cell communication|protein transport	endosome membrane|nucleus|plasma membrane	phosphatidylinositol binding|protein binding			kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(2)|stomach(1)	15						CCGAAAGCCTCGCGCAGCTCC	0.736000													7	4					0	0	1	0	0
H3F3C	440093	broad.mit.edu	37	12	31944879	31944879	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:31944879G>A	ENST00000340398.3	-	1	296	c.222C>T	c.(220-222)atC>atT	p.I74I		NM_001013699.2	NP_001013721.2	Q6NXT2	H3C_HUMAN	H3 histone, family 3C	74					nucleosome assembly	nucleosome|nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	18						AATCCTGCGCGATCTCCCTCA	0.587000										HNSCC(67;0.2)			27	60					0	0	1	0	0
RAPGEF4	11069	broad.mit.edu	37	2	173662258	173662258	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:173662258C>T	ENST00000264111.6	+	3	401	c.214C>T	c.(214-216)Cgc>Tgc	p.R72C	RAPGEF4_ENST00000409036.1_Missense_Mutation_p.R72C|RAPGEF4_ENST00000397081.3_Missense_Mutation_p.R72C			Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	72					blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(14)|lung(13)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47			OV - Ovarian serous cystadenocarcinoma(117;0.194)			CCCAGTATTTCGCCAGGGTGA	0.388000													8	6					0	0	1	0	0
SCG2	7857	broad.mit.edu	37	2	224463674	224463674	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:224463674G>A	ENST00000305409.2	-	2	559	c.327C>T	c.(325-327)gaC>gaT	p.D109D		NM_003469.4	NP_003460.2	P13521	SCG2_HUMAN	secretogranin II	109					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			NS(1)|breast(1)|endometrium(1)|kidney(6)|large_intestine(10)|liver(1)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	44		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		TTCTCATCCAGTCTTCTTCAC	0.438000													21	117					0	0	1	0	0
ZNF706	51123	broad.mit.edu	37	8	102212260	102212260	+	Silent	SNP	A	A	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:102212260A>T	ENST00000520347.1	-	3	3157	c.201T>A	c.(199-201)ctT>ctA	p.L67L	ZNF706_ENST00000519744.1_Intron|ZNF706_ENST00000517844.1_Silent_p.L67L|ZNF706_ENST00000311212.4_Silent_p.L67L|ZNF706_ENST00000520984.1_Silent_p.L67L|ZNF706_ENST00000519882.1_Silent_p.L67L|ZNF706_ENST00000518336.1_Silent_p.L67L|ZNF706_ENST00000521272.1_Silent_p.L67L			Q9Y5V0	ZN706_HUMAN	zinc finger protein 706	67						intracellular	zinc ion binding			large_intestine(1)|ovary(2)	3	all_cancers(14;3.3e-07)|all_epithelial(15;3.47e-09)|Lung NSC(17;3.44e-05)|all_lung(17;0.000117)		Epithelial(11;8.57e-11)|all cancers(13;1.43e-08)|OV - Ovarian serous cystadenocarcinoma(57;1.43e-05)			ATTCTGGAGGAAGTGGAGTCT	0.393000													40	44					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88300258	88300258	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:88300258G>A	ENST00000418177.2	-	8	2960	c.2593C>T	c.(2593-2595)Ctg>Ttg	p.L865L	GRM5_ENST00000393297.1_Silent_p.L865L|GRM5_ENST00000455756.2_Silent_p.L865L|GRM5_ENST00000305447.4_Silent_p.L865L|GRM5_ENST00000305432.5_Silent_p.L865L			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	865					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	CTCTTCCACAGGTTGACTAGG	0.562000													23	26					0	0	1	0	0
BPIFB6	128859	broad.mit.edu	37	20	31624268	31624268	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:31624268C>T	ENST00000349552.1	+	7	595	c.595C>T	c.(595-597)Cag>Tag	p.Q199*		NM_174897.2	NP_777557.1	Q8NFQ5	BPIL3_HUMAN	BPI fold containing family B, member 6	199						extracellular region	lipid binding										GCCTGTGGGCCAGATGGGCAC	0.587000													144	127					0	0	1	0	0
LST3	0	broad.mit.edu	37	12	21229393	21229393	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:21229393T>G	ENST00000540229.1	+	15	2003	c.1938T>G	c.(1936-1938)atT>atG	p.I646M	SLCO1B7_ENST00000421593.2_Missense_Mutation_p.I538M|LST3_ENST00000381541.3_Missense_Mutation_p.I585M|RP11-125O5.2_ENST00000590779.1_Missense_Mutation_p.F39C|SLCO1B7_ENST00000554957.1_Missense_Mutation_p.I585M|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.I646M																							CAGGAGGTATTCTAGTTCCAA	0.368000													29	51					0	0	1	0	0
H1FX	8971	broad.mit.edu	37	3	129034464	129034464	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:129034464C>T	ENST00000333762.4	-	1	656	c.282G>A	c.(280-282)aaG>aaA	p.K94K	H1FX-AS1_ENST00000511998.1_RNA|H1FX-AS1_ENST00000433902.2_RNA	NM_006026.3	NP_006017.1	Q92522	H1X_HUMAN	H1 histone family, member X	94	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			kidney(1)|ovary(1)|urinary_tract(2)	4						GCACCAGCGCCTTGATCGAGT	0.627000													3	1					0	0	1	0	0
PPIL2	23759	broad.mit.edu	37	22	22040810	22040810	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:22040810C>T	ENST00000406385.1	+	11	813	c.753C>T	c.(751-753)acC>acT	p.T251T	PPIL2_ENST00000335025.7_Silent_p.T251T|PPIL2_ENST00000456792.2_Silent_p.T230T|PPIL2_ENST00000492445.2_Silent_p.T251T|PPIL2_ENST00000398831.3_Silent_p.T251T|PPIL2_ENST00000412327.1_Silent_p.T251T			Q13356	PPIL2_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 2	251					blood coagulation|leukocyte migration|protein folding|protein polyubiquitination	Golgi lumen|nucleus|ubiquitin ligase complex	peptidyl-prolyl cis-trans isomerase activity|ubiquitin-ubiquitin ligase activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	17	Colorectal(54;0.105)					CTTCCTTCACCTCCACCGCGA	0.622000													48	54					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24877295	24877295	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:24877295G>A	ENST00000382554.3	+	3	737	c.419G>A	c.(418-420)cGa>cAa	p.R140Q		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	140					DNA integration	integral to membrane	DNA binding	p.R140Q(1)		breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						CTGGTGGGGCGACTGCGCTGG	0.682000													43	20					0	0	1	0	0
OR5P2	120065	broad.mit.edu	37	11	7817638	7817638	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:7817638C>T	ENST00000329434.2	-	1	882	c.852G>A	c.(850-852)ctG>ctA	p.L284L	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153444.1	NP_703145.1	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P, member 2	284					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)	22				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GGCTGTAGATCAGGGGGTTCA	0.413000													20	46					0	0	1	0	0
YARS	8565	broad.mit.edu	37	1	33276317	33276317	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:33276317G>A	ENST00000373477.4	-	3	1163	c.255C>T	c.(253-255)gcC>gcT	p.A85A		NM_003680.3	NP_003671.1	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	85					apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	GTTCCCATGGGGCTTTCATGT	0.458000													11	111					0	0	1	0	0
CCDC74B	91409	broad.mit.edu	37	2	130897599	130897599	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:130897599G>A	ENST00000392984.3	-	5	1996	c.1253C>T	c.(1252-1254)cCc>cTc	p.P418L	CCDC74B_ENST00000310463.6_Missense_Mutation_p.P316L|CCDC74B_ENST00000409943.3_Missense_Mutation_p.P250L			Q96LY2	CC74B_HUMAN	coiled-coil domain containing 74B	316										endometrium(2)|large_intestine(1)|lung(3)	6	Colorectal(110;0.1)					CACTCACCTGGGAAAGCTAGC	0.647000													48	17					0	0	1	0	0
ZNF550	162972	broad.mit.edu	37	19	58059238	58059238	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:58059238C>T	ENST00000325134.5	-	3	434	c.278G>A	c.(277-279)aGa>aAa	p.R93K	ZNF550_ENST00000457177.1_Missense_Mutation_p.R125K|ZNF549_ENST00000594943.1_Intron|ZNF549_ENST00000602149.1_Intron|ZNF550_ENST00000601415.1_Intron|ZNF550_ENST00000506609.2_Missense_Mutation_p.R84K			Q7Z398	ZN550_HUMAN	zinc finger protein 550	125					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	7		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATCCCTAGCTCTCCCCAACCT	0.527000													57	162					0	0	1	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701424	56701424	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:56701424G>A	ENST00000586855.2	-	5	1573	c.1260C>T	c.(1258-1260)ttC>ttT	p.F420F	ZSCAN5B_ENST00000358992.3_Silent_p.F420F			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	420					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						ACTCGTGGGCGAACCGCTTTT	0.567000													26	23					0	0	1	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72050821	72050821	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:72050821G>A	ENST00000378743.3	-	2	1217	c.859C>T	c.(859-861)Cct>Tct	p.P287S	ZFC3H1_ENST00000552037.1_Missense_Mutation_p.P287S|ZFC3H1_ENST00000549407.1_5'UTR|ZFC3H1_ENST00000548100.1_Missense_Mutation_p.P287S	NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	287					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						TTCTCCTCAGGAGCTACTTCT	0.363000													23	41					0	0	1	0	0
C10orf68	79741	broad.mit.edu	37	10	33140832	33140832	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:33140832C>T	ENST00000375030.2	+	21	2217	c.1599C>T	c.(1597-1599)caC>caT	p.H533H	C10orf68_ENST00000375025.4_Silent_p.H638H|C10orf68_ENST00000375028.3_Silent_p.H578H			Q9H943	CJ068_HUMAN	chromosome 10 open reading frame 68	574										breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(4)	29						AAGACATCCACCTTCCTTTAC	0.328000													51	18					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70954523	70954523	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:70954523C>T	ENST00000393567.2	-	46	7906	c.7756G>A	c.(7756-7758)Gag>Aag	p.E2586K		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	2586										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TTGTCGCTCTCTAGGGCCTGC	0.577000													7	16					0	0	1	0	0
SLC5A8	160728	broad.mit.edu	37	12	101560399	101560399	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:101560399G>A	ENST00000536262.2	-	12	1957	c.1399C>T	c.(1399-1401)Cct>Tct	p.P467S		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	467					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						GTTCTCTCAGGAAGTGGAGGA	0.418000													7	22					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9058282	9058282	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:9058282C>T	ENST00000397910.4	-	3	29367	c.29164G>A	c.(29164-29166)Gaa>Aaa	p.E9722K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9724	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTAGTTGTTTCCACAAAGCGA	0.488000													5	19					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9069352	9069352	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:9069352G>A	ENST00000397910.4	-	3	18297	c.18094C>T	c.(18094-18096)Cac>Tac	p.H6032Y		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6034	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGCTGGGAGTGGATTGAGACA	0.443000													33	71					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130929789	130929789	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:130929789C>T	ENST00000261655.4	-	7	719	c.556G>A	c.(556-558)Gag>Aag	p.E186K	RIMBP2_ENST00000536002.1_Missense_Mutation_p.E94K|RIMBP2_ENST00000535703.1_Missense_Mutation_p.E94K	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	186	SH3 1.					cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TCGGGGTTCTCGTTCGGTCCA	0.542000													18	32					0	0	1	0	0
NOL8	55035	broad.mit.edu	37	9	95077335	95077335	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:95077335C>T	ENST00000545558.1	-	7	2064	c.1572G>A	c.(1570-1572)aaG>aaA	p.K524K	NOL8_ENST00000542053.1_Silent_p.K456K|NOL8_ENST00000535387.1_Silent_p.K524K|NOL8_ENST00000358855.4_Silent_p.K456K|NOL8_ENST00000442668.2_Silent_p.K524K			Q76FK4	NOL8_HUMAN	nucleolar protein 8	524					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	16						TCTTGGGGCTCTTGGAGCCTC	0.527000													5	40					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130353469	130353469	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:130353469G>A	ENST00000358511.6	+	26	5059	c.5028_splice	c.e26+1	p.K1676_splice	COL6A6_ENST00000453409.2_Splice_Site_p.K1676_splice	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	1676	Triple-helical region.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						GTGGACCTAAGGTACCGTGTG	0.403000													3	10					0	0	1	0	0
PRB2	653247	broad.mit.edu	37	12	11546884	11546884	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:11546884C>T	ENST00000389362.4	-	3	163	c.128G>A	c.(127-129)gGa>gAa	p.G43E	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2									p.?(1)|p.A39_G59delAPPQGGNKPQGPPSPPGKPQG(1)		NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TTTGTTGCCTCCTTGTGGGGG	0.522000													54	157					0	0	1	0	0
PDLIM5	10611	broad.mit.edu	37	4	95575786	95575786	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:95575786C>T	ENST00000317968.4	+	10	1595	c.1459C>T	c.(1459-1461)Ctt>Ttt	p.L487F	PDLIM5_ENST00000380176.3_3'UTR|PDLIM5_ENST00000542407.1_Missense_Mutation_p.L365F|PDLIM5_ENST00000514743.1_Missense_Mutation_p.L516F|PDLIM5_ENST00000437932.1_Missense_Mutation_p.L378F	NM_001256428.1|NM_006457.4	NP_001243357.1|NP_006448.4	Q96HC4	PDLI5_HUMAN	PDZ and LIM domain 5	487	LIM zinc-binding 2.				regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)		AAGGAAGATCCTTGGAGTAAG	0.353000													35	19					0	0	1	0	0
PGR	5241	broad.mit.edu	37	11	100999493	100999493	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:100999493G>A	ENST00000325455.5	-	1	1762	c.309C>T	c.(307-309)ccC>ccT	p.P103P	PGR_ENST00000534013.1_Intron|PGR_ENST00000263463.5_Silent_p.P103P	NM_000926.4|NM_001202474.1	NP_000917.3|NP_001189403.1	P06401	PRGR_HUMAN	progesterone receptor	103	Modulating, Pro-Rich.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|liver(1)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	36		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	CCTTTTCTGGGGGACTAGAAC	0.627000													7	25					0	0	1	0	0
ZNF12	7559	broad.mit.edu	37	7	6730526	6730526	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:6730526G>A	ENST00000405858.1	-	5	2588	c.2047C>T	c.(2047-2049)Cat>Tat	p.H683Y	ZNF12_ENST00000342651.5_Missense_Mutation_p.H645Y|AC073343.13_ENST00000366167.2_RNA|ZNF12_ENST00000404360.1_Missense_Mutation_p.H609Y	NM_006956.2|NM_016265.3	NP_008887.2|NP_057349.2	P17014	ZNF12_HUMAN	zinc finger protein 12	683					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|endometrium(1)|large_intestine(1)|lung(7)|prostate(2)|upper_aerodigestive_tract(3)	16		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		CCTCTCCTATGAATTCTCTGA	0.373000													3	18					0	0	1	0	0
SNTG2	54221	broad.mit.edu	37	2	1168852	1168852	+	Missense_Mutation	SNP	G	G	A	rs145266598	by1000genomes	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:1168852G>A	ENST00000308624.5	+	8	703	c.574G>A	c.(574-576)Gga>Aga	p.G192R	SNTG2_ENST00000467759.1_3'UTR|SNTG2_ENST00000407292.1_Intron	NM_018968.3	NP_061841.2	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	192					central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding	p.G192R(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		GCATCTGAACGGAAACTCCAG	0.443000													112	55					0	0	1	0	0
NXF3	56000	broad.mit.edu	37	X	102337212	102337212	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:102337212C>T	ENST00000395065.3	-	9	962	c.861G>A	c.(859-861)acG>acA	p.T287T	NXF3_ENST00000425463.2_Silent_p.T198T|NXF3_ENST00000425644.1_5'UTR	NM_022052.1	NP_071335.1	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	287						cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26						CCGAGAAGGTCGTGCACACTG	0.542000													56	13					0	0	1	0	0
CAPN6	827	broad.mit.edu	37	X	110496411	110496411	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:110496411G>A	ENST00000324068.1	-	4	498	c.331C>T	c.(331-333)Cct>Tct	p.P111S	CAPN6_ENST00000541758.1_5'UTR	NM_014289.3	NP_055104.2	Q9Y6Q1	CAN6_HUMAN	calpain 6	111	Calpain catalytic.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(25)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	47						GTTTTTTGAGGGTCCCATTCC	0.393000													20	7					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	14101557	14101557	+	RNA	SNP	G	G	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:14101557G>T	ENST00000310358.7	+	0	1201							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		CACACCCAAAGGATTACCCTC	0.488000													10	25					7.03913e-09	7.11055e-09	1	1	0
OLFML3	56944	broad.mit.edu	37	1	114523104	114523104	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:114523104C>T	ENST00000369551.1	+	3	493	c.205C>T	c.(205-207)Cgt>Tgt	p.R69C	OLFML3_ENST00000393300.2_Missense_Mutation_p.R69C|OLFML3_ENST00000320334.4_Missense_Mutation_p.R89C|OLFML3_ENST00000491700.1_3'UTR			Q9NRN5	OLFL3_HUMAN	olfactomedin-like 3	89					multicellular organismal development	extracellular region				breast(1)|endometrium(2)|large_intestine(3)|lung(3)|prostate(2)|skin(2)|urinary_tract(1)	14	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAGAGTGGATCGTCTGGAGCG	0.587000													63	22					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105410201	105410201	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:105410201G>A	ENST00000333244.5	-	7	11706	c.11587C>T	c.(11587-11589)Caa>Taa	p.Q3863*	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3863						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGGCGAGCTTGGACCGTCAGG	0.612000													145	98					0	0	1	0	0
SRRM3	222183	broad.mit.edu	37	7	75877511	75877511	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:75877511C>A	ENST00000388802.4	+	3	448	c.239C>A	c.(238-240)tCg>tAg	p.S80*	SRRM3_ENST00000326382.8_Nonsense_Mutation_p.S80*					serine/arginine repetitive matrix 3											NS(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|pancreas(1)	8						TGCAGGTATTCGGAGGAGGAG	0.632000													8	10					1.12685e-05	1.13445e-05	1	1	0
ZNF793	390927	broad.mit.edu	37	19	38028341	38028341	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:38028341G>A	ENST00000445217.1	+	4	816	c.781G>A	c.(781-783)Ggg>Agg	p.G261R	ZNF793_ENST00000542455.1_Missense_Mutation_p.G261R|ZNF793_ENST00000588578.1_3'UTR|ZNF793_ENST00000589319.1_Intron|ZNF793_ENST00000587143.1_Missense_Mutation_p.G261R			Q6ZN11	ZN793_HUMAN	zinc finger protein 793	261					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(2)|lung(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CACTGACTGTGGGAAAGCCTT	0.458000													5	15					0	0	1	0	0
PRX	57716	broad.mit.edu	37	19	40902447	40902447	+	Silent	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:40902447T>C	ENST00000324001.7	-	7	2082	c.1812A>G	c.(1810-1812)caA>caG	p.Q604Q	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	604	55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CCTTCGGGAGTTGCACTTCAG	0.542000													102	73					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3214386	3214386	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:3214386C>T	ENST00000355072.5	+	49	6869	c.6724C>T	c.(6724-6726)Cct>Tct	p.P2242S		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	2242					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		TTTGCACCTTCCTCCTGAGAA	0.587000													26	76					0	0	1	0	0
SETBP1	26040	broad.mit.edu	37	18	42532419	42532419	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr18:42532419C>T	ENST00000282030.5	+	4	3410	c.3114C>T	c.(3112-3114)ttC>ttT	p.F1038F		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	1038						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		TACAAGGGTTCAGCTACCCTA	0.448000									Schinzel-Giedion syndrome				21	21					0	0	1	0	0
LSM10	84967	broad.mit.edu	37	1	36859427	36859427	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:36859427G>A	ENST00000315732.2	-	2	453	c.304C>T	c.(304-306)Cat>Tat	p.H102Y	LSM10_ENST00000476041.1_5'UTR	NM_032881.1	NP_116270.1	Q969L4	LSM10_HUMAN	LSM10, U7 small nuclear RNA associated	102					histone mRNA metabolic process|mRNA processing|RNA splicing|S phase of mitotic cell cycle|termination of RNA polymerase II transcription	Cajal body|U7 snRNP	histone pre-mRNA DCP binding|protein binding			upper_aerodigestive_tract(1)|urinary_tract(1)	2		Myeloproliferative disorder(586;0.0393)				CGCACCCGATGGATAATCTGC	0.567000													76	23					0	0	1	0	0
KCNH4	23415	broad.mit.edu	37	17	40327692	40327692	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:40327692G>A	ENST00000264661.3	-	6	1224	c.892C>T	c.(892-894)Cgt>Tgt	p.R298C	KCNH4_ENST00000607371.1_Missense_Mutation_p.R298C	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	298					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CCAATGGAACGAGGAGCAGAG	0.547000													68	10					0	0	1	0	0
TRBV5-1	28614	broad.mit.edu	37	7	142020937	142020937	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:142020937G>A	ENST00000390381.3	+	0	353																											TGTCTCCTGGGAGCAGGTGAG	0.607000													5	6					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41365258	41365258	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:41365258G>A	ENST00000547849.1	+	16	2146	c.1827G>A	c.(1825-1827)gaG>gaA	p.E609E	CNTN1_ENST00000347616.1_Intron|CNTN1_ENST00000551295.2_Intron|CNTN1_ENST00000348761.2_Intron|CNTN1_ENST00000360099.3_Silent_p.E609E|CNTN1_ENST00000547702.1_Silent_p.E609E	NM_001256064.1	NP_001242993.1	Q12860	CNTN1_HUMAN	contactin 1	0	Fibronectin type-III 1.|Gly/Pro-rich.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				AAGGTGGAGAGAAAAACATGG	0.468000													4	13					0	0	1	0	0
EPB41L4B	54566	broad.mit.edu	37	9	112005953	112005953	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:112005953G>A	ENST00000374566.3	-	15	1871	c.1354C>T	c.(1354-1356)Cat>Tat	p.H452Y	EPB41L4B_ENST00000374557.4_Missense_Mutation_p.H452Y	NM_019114.3	NP_061987.3	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	452						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						ATATTAGGATGATATTGAGGC	0.463000													7	18					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167792324	167792324	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:167792324C>A	ENST00000367848.1	-	29	4311	c.3814G>T	c.(3814-3816)Gag>Tag	p.E1272*	ADCY10_ENST00000545172.1_Nonsense_Mutation_p.E1211*|ADCY10_ENST00000485964.1_5'UTR|ADCY10_ENST00000367851.4_Nonsense_Mutation_p.E1364*			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	1364					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						ACAGAAAGCTCCCACAGCCGC	0.448000													59	27					3.30712e-30	3.37684e-30	1	1	0
TIMM10B	26515	broad.mit.edu	37	11	6503414	6503414	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:6503414C>T	ENST00000254616.6	+	3	345	c.275C>T	c.(274-276)gCt>gTt	p.A92V	TIMM10B_ENST00000472836.1_Missense_Mutation_p.A92V|TIMM10B_ENST00000530751.1_Missense_Mutation_p.A60V	NM_012192.3	NP_036324.1			translocase of inner mitochondrial membrane 10 homolog B (yeast)																		CCAGGCGTTGCTGCTGAACAG	0.632000													24	13					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38692515	38692515	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:38692515C>T	ENST00000222345.6	+	20	5507	c.4998C>T	c.(4996-4998)gtC>gtT	p.V1666V		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	1666					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			AAAGAGCCGTCTCACTCTTCT	0.662000													35	17					0	0	1	0	0
EPHA10	284656	broad.mit.edu	37	1	38227125	38227125	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:38227125G>A	ENST00000373048.4	-	3	801	c.802C>T	c.(802-804)Cgc>Tgc	p.R268C	EPHA10_ENST00000319637.6_Missense_Mutation_p.R268C|EPHA10_ENST00000427468.2_Missense_Mutation_p.R268C	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	268						extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CAGCTGCAGCGGCCCACAGGC	0.692000													19	123					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29130442	29130442	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:29130442G>A	ENST00000382580.2	-	2	343	c.268C>T	c.(268-270)Cct>Tct	p.P90S	CHEK2_ENST00000382566.1_Missense_Mutation_p.P90S|CHEK2_ENST00000405598.1_Missense_Mutation_p.P90S|CHEK2_ENST00000328354.6_Missense_Mutation_p.P90S|CHEK2_ENST00000348295.3_Missense_Mutation_p.P90S|CHEK2_ENST00000544772.1_5'UTR|CHEK2_ENST00000403642.1_Missense_Mutation_p.P90S|CHEK2_ENST00000402731.1_Missense_Mutation_p.P90S|CHEK2_ENST00000404276.1_Missense_Mutation_p.P90S|CHEK2_ENST00000382578.1_Missense_Mutation_p.P90S|CHEK2_ENST00000382565.1_Missense_Mutation_p.P90S	NM_001005735.1	NP_001005735.1	O96017	CHK2_HUMAN	checkpoint kinase 2	90					cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CAGGGGGCAGGGGTAGGCTCC	0.488000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					13	19					0	0	1	0	0
MANEA	79694	broad.mit.edu	37	6	96034537	96034537	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:96034537G>T	ENST00000358812.4	+	2	356	c.222G>T	c.(220-222)aaG>aaT	p.K74N	MANEA_ENST00000369293.1_Missense_Mutation_p.K74N	NM_024641.3	NP_078917.2	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	74	Catalytic (Probable).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			breast(2)|endometrium(3)|kidney(2)|liver(2)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		CAAATACCAAGAATTTAAAAA	0.333000													12	44					0.00010058	0.000101088	1	1	0
PSME4	23198	broad.mit.edu	37	2	54147374	54147374	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:54147374G>A	ENST00000404125.1	-	19	2431	c.2376C>T	c.(2374-2376)ctC>ctT	p.L792L	PSME4_ENST00000421748.2_Intron	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4	792					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding	p.L678L(1)|p.L792L(1)		breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GGAGTTTGACGAGCTCAGGCT	0.403000													45	247					0	0	1	0	0
KIF21A	55605	broad.mit.edu	37	12	39760928	39760928	+	Silent	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:39760928T>C	ENST00000395670.3	-	5	1058	c.639A>G	c.(637-639)acA>acG	p.T213T	KIF21A_ENST00000541463.2_Silent_p.T213T|KIF21A_ENST00000361961.3_Silent_p.T213T|KIF21A_ENST00000544797.2_Silent_p.T213T|KIF21A_ENST00000361418.5_Silent_p.T213T			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	213	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				TACTGGCAGTTGTCCGGGATA	0.413000													12	29					0	0	1	0	0
SSBP2	23635	broad.mit.edu	37	5	80770329	80770329	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:80770329G>A	ENST00000320672.4	-	7	695	c.485C>T	c.(484-486)cCa>cTa	p.P162L	SSBP2_ENST00000509053.1_Missense_Mutation_p.P132L|SSBP2_ENST00000515395.1_Missense_Mutation_p.P132L|SSBP2_ENST00000514493.1_Missense_Mutation_p.P132L|SSBP2_ENST00000505980.1_Missense_Mutation_p.P142L	NM_001256732.1|NM_001256733.1|NM_012446.3	NP_001243661.1|NP_001243662.1|NP_036578.2	P81877	SSBP2_HUMAN	single-stranded DNA binding protein 2	162	Gly-rich.|Pro-rich.				regulation of transcription, DNA-dependent	cytoplasm|nucleus	single-stranded DNA binding		SSBP2/JAK2(4)	central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	10		Lung NSC(167;0.00154)|all_lung(232;0.00179)|Ovarian(174;0.0338)		OV - Ovarian serous cystadenocarcinoma(54;1.07e-41)|Epithelial(54;2.79e-35)|all cancers(79;1.18e-29)		TTGTCGAGTTGGATCCATTCC	0.343000													9	4					0	0	1	0	0
LRRC66	339977	broad.mit.edu	37	4	52861586	52861586	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:52861586G>A	ENST00000343457.3	-	4	1608	c.1602C>T	c.(1600-1602)ctC>ctT	p.L534L		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	534						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						TCCATTCTCCGAGAATATCAT	0.512000													24	64					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7289621	7289621	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:7289621C>T	ENST00000537408.1	+	6	1699	c.1161C>T	c.(1159-1161)acC>acT	p.T387T	CLSTN3_ENST00000266546.6_Silent_p.T375T			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	375					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						ACCACTTCACCCTGTCCTTCT	0.587000													15	42					0	0	1	0	0
TRIML2	205860	broad.mit.edu	37	4	189013033	189013033	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:189013033T>C	ENST00000512729.1	-	7	1032	c.658A>G	c.(658-660)Act>Gct	p.T220A	TRIML2_ENST00000326754.3_Missense_Mutation_p.T245A	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	220	B30.2/SPRY.						ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		AATCTCATAGTTCTCAGGTCC	0.512000													40	33					0	0	1	0	0
AMICA1	120425	broad.mit.edu	37	11	118081248	118081248	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:118081248C>T	ENST00000292067.7	-	3	789	c.348G>A	c.(346-348)gtG>gtA	p.V116V	AMICA1_ENST00000526620.1_Silent_p.V87V|AMICA1_ENST00000533261.1_Silent_p.V126V|AMICA1_ENST00000356289.5_Silent_p.V126V	NM_153206.2	NP_694938.2	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen 1	126	Ig-like V-type 1.				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane				central_nervous_system(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|stomach(2)	20	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		CCTTCTTGAACACCTGGCTCT	0.512000													12	29					0	0	1	0	0
WNK3	65267	broad.mit.edu	37	X	54264797	54264797	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:54264797G>A	ENST00000354646.2	-	19	4430	c.3992C>T	c.(3991-3993)tCa>tTa	p.S1331L	WNK3_ENST00000375169.3_Missense_Mutation_p.S1284L|WNK3_ENST00000375159.2_Missense_Mutation_p.S1331L	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	1284					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						CCGCTGAAATGATCCACTCAT	0.443000													21	5					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215963404	215963404	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:215963404C>T	ENST00000366943.2	-	51	10565	c.10179G>A	c.(10177-10179)atG>atA	p.M3393I	USH2A_ENST00000307340.3_Missense_Mutation_p.M3393I			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3393					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CAATTACCTTCATCATCATTC	0.333000										HNSCC(13;0.011)			5	60					0	0	1	0	0
FAM160B2	64760	broad.mit.edu	37	8	21956044	21956044	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:21956044C>T	ENST00000289921.7	+	7	925	c.879C>T	c.(877-879)atC>atT	p.I293I		NM_022749.5	NP_073586.5	Q86V87	F16B2_HUMAN	family with sequence similarity 160, member B2	293										endometrium(2)|kidney(1)|lung(2)|prostate(3)|urinary_tract(1)	9						GCCCTGCGATCGTCCGGCACC	0.642000													11	17					0	0	1	0	0
CHD8	57680	broad.mit.edu	37	14	21870592	21870592	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:21870592G>A	ENST00000399982.2	-	18	3849	c.3785C>T	c.(3784-3786)tCc>tTc	p.S1262F	CHD8_ENST00000557364.1_Missense_Mutation_p.S1262F|CHD8_ENST00000555962.1_5'UTR|CHD8_ENST00000430710.3_Missense_Mutation_p.S983F	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1262	Helicase C-terminal.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		TCTCTCGTAGGAATTACGAGT	0.483000													8	34					0	0	1	0	0
ZMYND8	23613	broad.mit.edu	37	20	45850067	45850067	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:45850067G>A	ENST00000311275.7	-	20	3508	c.3255C>T	c.(3253-3255)tcC>tcT	p.S1085S	ZMYND8_ENST00000471951.2_Silent_p.S1105S|ZMYND8_ENST00000355972.4_Silent_p.S1085S|ZMYND8_ENST00000540497.1_Silent_p.S1033S|ZMYND8_ENST00000396281.4_Silent_p.S1085S|ZMYND8_ENST00000262975.4_Silent_p.S1039S|ZMYND8_ENST00000372023.3_Silent_p.S1007S|ZMYND8_ENST00000360911.3_Silent_p.S1034S|ZMYND8_ENST00000536340.1_Silent_p.S1112S|ZMYND8_ENST00000461685.1_Silent_p.S1059S|ZMYND8_ENST00000458360.2_Silent_p.S953S|ZMYND8_ENST00000446994.2_Silent_p.S976S|ZMYND8_ENST00000352431.2_Silent_p.S1059S			Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8	1085							protein binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|prostate(3)|skin(2)|urinary_tract(8)	62			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			TCCCCTGGGAGGACTTATTTA	0.537000													22	35					0	0	1	0	0
SYT10	341359	broad.mit.edu	37	12	33579075	33579075	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:33579075G>A	ENST00000228567.3	-	2	803	c.507C>T	c.(505-507)acC>acT	p.T169T	SYT10_ENST00000535526.1_5'UTR|SYT10_ENST00000567656.1_5'UTR	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	169						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					TTCCTTACCGGGTTGATGACG	0.398000													27	94					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152275974	152275974	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:152275974C>T	ENST00000368799.1	-	3	11423	c.11388G>A	c.(11386-11388)agG>agA	p.R3796R	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3796	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGGCATCAGACCTTCCCTGGG	0.572000									Ichthyosis				94	625					0	0	1	0	0
EXT2	2132	broad.mit.edu	37	11	44148390	44148390	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:44148390C>T	ENST00000395673.3	+	6	1119	c.1063C>T	c.(1063-1065)Cgt>Tgt	p.R355C	EXT2_ENST00000358681.4_Missense_Mutation_p.R322C|EXT2_ENST00000343631.3_Missense_Mutation_p.R322C|EXT2_ENST00000533608.1_Missense_Mutation_p.R322C	NM_000401.3	NP_000392.3	Q93063	EXT2_HUMAN	exostosin glycosyltransferase 2	322					glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|lung(17)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	32						TGTGGTTCTTCGTGGAGCTCG	0.478000			"""Mis, N, F, S"""			"""exostoses, osteosarcoma"""			Hereditary Multiple Exostoses				32	94					0	0	1	0	0
ADAD2	161931	broad.mit.edu	37	16	84230343	84230343	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:84230343C>T	ENST00000268624.3	+	10	1956	c.1863C>T	c.(1861-1863)ctC>ctT	p.L621L	ADAD2_ENST00000315906.5_Silent_p.L539L|RP11-486L19.2_ENST00000565643.1_RNA|RP11-486L19.2_ENST00000569834.1_RNA|RP11-486L19.2_ENST00000536986.1_RNA	NM_139174.3	NP_631913.3	Q8NCV1	ADAD2_HUMAN	adenosine deaminase domain containing 2	539					RNA processing	intracellular	adenosine deaminase activity|double-stranded RNA binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|skin(1)	13						AGCCCTACCTCCTGGCCTTGA	0.682000													35	60					0	0	1	0	0
OR10G7	390265	broad.mit.edu	37	11	123909028	123909028	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:123909028G>A	ENST00000330487.5	-	1	689	c.681C>T	c.(679-681)atC>atT	p.I227I		NM_001004463.1	NP_001004463.1	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G, member 7	227					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(6)|lung(20)|ovary(2)|prostate(2)|stomach(3)|urinary_tract(1)	47		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CTGAGGTGCGGATCCGCAGGA	0.537000													17	56					0	0	1	0	0
KCNA10	3744	broad.mit.edu	37	1	111060034	111060034	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:111060034T>C	ENST00000369771.2	-	1	1763	c.1376A>G	c.(1375-1377)aAc>aGc	p.N459S		NM_005549.2	NP_005540.1	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 10	459						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(3)|skin(1)|urinary_tract(1)	35		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		GTAATTGAAGTTGGAGACAAT	0.522000													36	9					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141755436	141755436	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:141755436C>T	ENST00000475668.2	+	28	3447	c.3393C>T	c.(3391-3393)ctC>ctT	p.L1131L	MGAM_ENST00000549489.2_Silent_p.L1131L			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1131	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CCAAGTACCTCTATGGCTTTG	0.532000													30	22					0	0	1	0	0
KIAA1211L	343990	broad.mit.edu	37	2	99463230	99463230	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:99463230G>A	ENST00000397899.2	-	2	365	c.34C>T	c.(34-36)Cgg>Tgg	p.R12W	KIAA1211L_ENST00000462314.1_5'UTR	NM_207362.2	NP_997245.2			KIAA1211-like																		GCAGCCTCCCGAAGCTTAATG	0.512000													47	20					0	0	1	0	0
MTMR4	9110	broad.mit.edu	37	17	56573456	56573456	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:56573456G>A	ENST00000323456.5	-	16	2171	c.2047C>T	c.(2047-2049)Cag>Tag	p.Q683*	MTMR4_ENST00000579925.1_Nonsense_Mutation_p.Q626*	NM_004687.4	NP_004678.3	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	683						cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			breast(10)|endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|skin(5)	36	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TAGTCTTTCTGGCTGCTGGGC	0.493000													122	16					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9064344	9064344	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:9064344G>A	ENST00000397910.4	-	3	23305	c.23102C>T	c.(23101-23103)cCt>cTt	p.P7701L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7703	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGTGGAAACAGGATGAGGTGA	0.562000													18	40					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76753131	76753131	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr18:76753131C>T	ENST00000536229.3	+	1	1450	c.741C>T	c.(739-741)atC>atT	p.I247I	SALL3_ENST00000575389.2_Silent_p.I380I|SALL3_ENST00000537592.2_Silent_p.I380I			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	380					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		TGGTCAGCATCGCGGCCACGG	0.697000													6	7					0	0	1	0	0
ROBO3	64221	broad.mit.edu	37	11	124745039	124745039	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:124745039C>T	ENST00000397801.1	+	14	2298	c.2106C>T	c.(2104-2106)ttC>ttT	p.F702F	ROBO3_ENST00000538940.1_Silent_p.F680F	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	702	Fibronectin type-III 2.				axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		TGCAAGGTTTCCGGGTGTCTT	0.607000													6	8					0	0	1	0	0
HTR4	3360	broad.mit.edu	37	5	147889410	147889410	+	Silent	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:147889410A>G	ENST00000360693.3	-	6	823	c.685T>C	c.(685-687)Tta>Cta	p.L229L	HTR4_ENST00000521735.1_Silent_p.L229L|HTR4_ENST00000377888.3_Silent_p.L229L|HTR4_ENST00000314512.6_Silent_p.L229L|HTR4_ENST00000354217.2_Silent_p.L229L|HTR4_ENST00000362016.2_Silent_p.L243L|HTR4_ENST00000520514.1_Silent_p.L229L|HTR4_ENST00000521530.1_Silent_p.L229L|HTR4_ENST00000517929.1_Silent_p.L229L	NM_001040173.2	NP_001035263.1	Q13639	5HT4R_HUMAN	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	229					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	GCCCGTTGTAACATCTGGATC	0.557000													15	9					0	0	1	0	0
GJA10	84694	broad.mit.edu	37	6	90604243	90604243	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:90604243C>T	ENST00000369352.1	+	1	56	c.56C>T	c.(55-57)aCc>aTc	p.T19I		NM_032602.1	NP_115991.1	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10, 62kDa	19					synaptic transmission	connexon complex|integral to membrane	gap junction channel activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(17)|ovary(1)|skin(3)|urinary_tract(1)	37		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		TCCCACTCAACCATAGTGGGG	0.458000													71	65					0	0	1	0	0
ACTL9	284382	broad.mit.edu	37	19	8808104	8808104	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:8808104G>A	ENST00000324436.3	-	1	1068	c.948C>T	c.(946-948)tcC>tcT	p.S316S		NM_178525.3	NP_848620.2	Q8TC94	ACTL9_HUMAN	actin-like 9	316						cytoplasm|cytoskeleton				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(15)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	36						TGGCCATGGTGGAGAGGCCGA	0.652000													18	55					0	0	1	0	0
TMEM38A	79041	broad.mit.edu	37	19	16791316	16791316	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:16791316C>T	ENST00000187762.2	+	3	481	c.390C>T	c.(388-390)atC>atT	p.I130I		NM_024074.1	NP_076979.1	Q9H6F2	TM38A_HUMAN	transmembrane protein 38A	130						integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)	15						TCCGCAAGATCGCGGTGGGCA	0.527000													47	134					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73066268	73066268	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:73066268G>A	ENST00000429829.1	-	0	6320					NR_001564.2																						TAGTGCATAGGATCCCAGACG	0.488000													23	4					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6189052	6189052	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:6189052C>T	ENST00000262450.3	-	23	3564	c.3465G>A	c.(3463-3465)gaG>gaA	p.E1155E	CHD5_ENST00000378021.1_Silent_p.E12E	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1155	Helicase C-terminal.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TGATGCGCTCCTCCACCGAGG	0.657000													38	21					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153026613	153026613	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:153026613G>A	ENST00000285900.5	+	3	689	c.346G>A	c.(346-348)Gat>Aat	p.D116N	GRIA1_ENST00000518142.1_Intron|GRIA1_ENST00000518862.1_3'UTR|GRIA1_ENST00000521843.2_Missense_Mutation_p.D47N|GRIA1_ENST00000448073.4_Missense_Mutation_p.D126N|GRIA1_ENST00000340592.5_Missense_Mutation_p.D116N|GRIA1_ENST00000518783.1_Missense_Mutation_p.D126N	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	116					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CTTTCCCGTTGATACATCCAA	0.478000													46	16					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103120150	103120150	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:103120150C>T	ENST00000295269.4	+	3	1421	c.964C>T	c.(964-966)Ctc>Ttc	p.L322F		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	322					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						AACCCTCTATCTCTCCGGCAT	0.428000													21	65					0	0	1	0	0
FGFRL1	53834	broad.mit.edu	37	4	1018763	1018763	+	Silent	SNP	C	C	T	rs146112374		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:1018763C>T	ENST00000398484.2	+	8	1723	c.1143C>T	c.(1141-1143)atC>atT	p.I381I	FGFRL1_ENST00000510644.1_Silent_p.I381I|FGFRL1_ENST00000504138.1_Silent_p.I381I|FGFRL1_ENST00000264748.6_Silent_p.I381I			Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	381					regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			CCGTGGTCATCGGCATCCCAG	0.682000													13	41					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112650407	112650407	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:112650407G>A	ENST00000550722.1	-	49	7470	c.7075C>T	c.(7075-7077)Cct>Tct	p.P2359S	HECTD4_ENST00000430131.2_Missense_Mutation_p.P2083S|HECTD4_ENST00000377560.5_Missense_Mutation_p.P2333S	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		TGTCCCGGAGGAGGTGGAGTC	0.532000													26	29					0	0	1	0	0
MGAT4C	25834	broad.mit.edu	37	12	86373909	86373909	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:86373909G>A	ENST00000604798.1	-	8	1799	c.595C>T	c.(595-597)Cgt>Tgt	p.R199C	MGAT4C_ENST00000548651.1_Missense_Mutation_p.R199C|MGAT4C_ENST00000332156.1_Missense_Mutation_p.R199C|MGAT4C_ENST00000393205.2_Missense_Mutation_p.R228C|MGAT4C_ENST00000552435.2_Intron|MGAT4C_ENST00000549405.2_Missense_Mutation_p.R199C|MGAT4C_ENST00000552808.2_Missense_Mutation_p.R199C			Q9UBM8	MGT4C_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)	199					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						TGCTTGGAACGAAATTTGACT	0.338000													13	49					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50960188	50960188	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:50960188C>T	ENST00000374103.4	-	5	670	c.585G>A	c.(583-585)cgG>cgA	p.R195R	OGDHL_ENST00000432695.1_5'UTR|OGDHL_ENST00000419399.1_Silent_p.R138R	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	195					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						CCTCCAGGCGCCGAATGATCT	0.562000													36	8					0	0	1	0	0
LPPR4	9890	broad.mit.edu	37	1	99771753	99771753	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:99771753C>T	ENST00000370185.3	+	7	1976	c.1479C>T	c.(1477-1479)gaC>gaT	p.D493D	LPPR4_ENST00000370184.1_Silent_p.D335D|LPPR4_ENST00000457765.1_Silent_p.D435D	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		493							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		TGAATGGAGACCACCATGGTC	0.552000													207	70					0	0	1	0	0
SLC39A3	29985	broad.mit.edu	37	19	2737140	2737140	+	Missense_Mutation	SNP	C	C	T	rs35127617		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:2737140C>T	ENST00000455372.2	-	2	321	c.116G>A	c.(115-117)cGc>cAc	p.R39H	AC006538.4_ENST00000586572.1_Missense_Mutation_p.R39H|SLC39A3_ENST00000545664.1_Missense_Mutation_p.R39H|SLC39A3_ENST00000269740.4_Missense_Mutation_p.R39H	NM_213568.1	NP_998733.1	Q9BRY0	S39A3_HUMAN	solute carrier family 39 (zinc transporter), member 3	39						integral to membrane|plasma membrane	zinc ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	10		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTTTTTCGAGCGATGGGCCTT	0.552000													5	25					0	0	1	0	0
MYOF	26509	broad.mit.edu	37	10	95111581	95111581	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:95111581G>A	ENST00000371501.4	-	33	3626	c.3504C>T	c.(3502-3504)ttC>ttT	p.F1168F	MYOF_ENST00000371502.4_Silent_p.F1168F|MYOF_ENST00000358334.5_Silent_p.F1155F|MYOF_ENST00000359263.4_Silent_p.F1168F			Q9NZM1	MYOF_HUMAN	myoferlin	1168	C2 4.				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TCCGATGGAGGAAACAGATAT	0.438000													37	12					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	10274119	10274119	+	Silent	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:10274119T>C	ENST00000396573.2	-	3	459	c.150A>G	c.(148-150)gaA>gaG	p.E50E	GRIN2A_ENST00000396575.2_Silent_p.E50E|GRIN2A_ENST00000562109.1_Silent_p.E50E|GRIN2A_ENST00000404927.2_Silent_p.E50E|GRIN2A_ENST00000330684.3_Silent_p.E50E	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	50					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GTGTTCGAAGTTCGCGCTCTG	0.677000													36	85					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	43985983	43985983	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:43985983G>A	ENST00000262726.7	-	24	3256	c.3003C>T	c.(3001-3003)acC>acT	p.T1001T	EFCAB6_ENST00000396231.2_Silent_p.T849T	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	1001					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				GCTCCCCTTCGGTAAGAGAAC	0.408000													39	63					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66947073	66947073	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:66947073G>A	ENST00000299752.4	-	9	1208	c.1015C>T	c.(1015-1017)Cgt>Tgt	p.R339C	CDH16_ENST00000570262.1_Missense_Mutation_p.R259C|CDH16_ENST00000565796.1_Missense_Mutation_p.R339C|CDH16_ENST00000568632.1_Missense_Mutation_p.R242C|CDH16_ENST00000394055.3_Missense_Mutation_p.R339C	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	339					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GTGGGGTCACGGGGAGGGCAG	0.582000													65	113					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36893779	36893779	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:36893779G>A	ENST00000429976.2	-	13	4722	c.4475C>T	c.(4474-4476)tCt>tTt	p.S1492F	TRANK1_ENST00000301807.6_Missense_Mutation_p.S942F|TRANK1_ENST00000428977.2_Missense_Mutation_p.S942F			O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1492					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GCGATCAAAAGATTCTGGGAA	0.438000													11	5					0	0	1	0	0
SNX31	169166	broad.mit.edu	37	8	101609037	101609037	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:101609037C>T	ENST00000311812.2	-	10	958	c.808G>A	c.(808-810)Gga>Aga	p.G270R	SNX31_ENST00000428383.2_Missense_Mutation_p.G171R	NM_152628.3	NP_689841.3	Q8N9S9	SNX31_HUMAN	sorting nexin 31	270					cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			TGCAGGTATCCATAGTGCCGT	0.527000													37	95					0	0	1	0	0
NDST3	9348	broad.mit.edu	37	4	119026174	119026174	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:119026174C>T	ENST00000296499.5	+	3	1386	c.981_splice	c.e3-1	p.A328_splice	NDST3_ENST00000433996.2_Intron	NM_004784.2	NP_004775.1	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	328	Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	54						GTATTTCAGGCCCTGCTTGAT	0.333000													14	55					0	0	1	0	0
NFAT5	10725	broad.mit.edu	37	16	69726657	69726657	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:69726657C>T	ENST00000349945.1	+	14	4199	c.2647C>T	c.(2647-2649)Cct>Tct	p.P883S	NFAT5_ENST00000567239.1_Missense_Mutation_p.P976S|NFAT5_ENST00000393742.2_Missense_Mutation_p.P883S|NFAT5_ENST00000354436.2_Missense_Mutation_p.P959S|NFAT5_ENST00000432919.1_Missense_Mutation_p.P977S|NFAT5_ENST00000566899.1_Missense_Mutation_p.P883S	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	959	Poly-Gln.				excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						TTCTTCTCCTCCTGCAGTTTC	0.448000													25	40					0	0	1	0	0
AIRE	326	broad.mit.edu	37	21	45706962	45706962	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr21:45706962G>A	ENST00000291582.5	+	3	536	c.409G>A	c.(409-411)Gag>Aag	p.E137K		NM_000383.3	NP_000374.1	O43918	AIRE_HUMAN	autoimmune regulator	137					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)|urinary_tract(1)	14				Colorectal(79;0.0806)		GGCCTCAGAAGAGGCTCGAGC	0.692000									Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy				24	30					0	0	1	0	0
CPM	1368	broad.mit.edu	37	12	69265632	69265632	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:69265632G>A	ENST00000551568.1	-	4	423	c.363C>T	c.(361-363)atC>atT	p.I121I	CPM_ENST00000338356.3_Silent_p.I121I|CPM_ENST00000546373.1_Silent_p.I121I	NM_001005502.2|NM_198320.3	NP_001005502.1|NP_938079.1	P14384	CBPM_HUMAN	carboxypeptidase M	121					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding			large_intestine(1)|lung(6)|prostate(2)	9	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			TGGAAGGCATGATGTGTATCC	0.458000													20	51					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58141765	58141765	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:58141765C>T	ENST00000295956.4	+	41	7016	c.6851C>T	c.(6850-6852)tCc>tTc	p.S2284F	FLNB_ENST00000358537.3_Missense_Mutation_p.S2260F|FLNB_ENST00000348383.5_Missense_Mutation_p.S2243F|FLNB_ENST00000429972.2_Missense_Mutation_p.S2273F|FLNB_ENST00000357272.4_3'UTR|FLNB_ENST00000419752.2_Missense_Mutation_p.S2104F|FLNB_ENST00000493452.1_Missense_Mutation_p.S2091F|FLNB_ENST00000490882.1_Missense_Mutation_p.S2315F	NM_001457.3	NP_001448.2	O75369	FLNB_HUMAN	filamin B, beta	2284	Interaction with INPPL1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		ATCGCACCCTCCGACGACGCC	0.582000													26	25					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12855850	12855850	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:12855850C>T	ENST00000332296.7	+	4	1233	c.1130C>T	c.(1129-1131)tCc>tTc	p.S377F	PRAMEF1_ENST00000400814.3_Missense_Mutation_p.S132F	NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	377										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AGCCGGTGCTCCCAGCTCACC	0.557000													5	32					0	0	1	0	0
AGER	177	broad.mit.edu	37	6	32150705	32150705	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:32150705G>A	ENST00000375076.4	-	6	705	c.604C>T	c.(604-606)Ccc>Tcc	p.P202S	AGER_ENST00000375069.3_Missense_Mutation_p.P101S|AGER_ENST00000438221.2_Missense_Mutation_p.P218S|AGER_ENST00000375070.3_Missense_Mutation_p.P233S|AGER_ENST00000375067.3_Missense_Mutation_p.P188S|AGER_ENST00000375055.2_Missense_Mutation_p.P202S|RNF5_ENST00000427134.2_Intron|AGER_ENST00000375065.5_Intron	NM_001136.4|NM_001206929.1|NM_001206932.1	NP_001127.1|NP_001193858.1|NP_001193861.1	Q15109	RAGE_HUMAN	advanced glycosylation end product-specific receptor	202	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|inflammatory response|innate immune response|neuron projection development|positive regulation of NF-kappaB transcription factor activity	integral to plasma membrane	S100 alpha binding|transmembrane receptor activity			breast(1)|endometrium(1)|lung(5)|pancreas(2)	9						GTGGGACGGGGATCTCCTCCC	0.627000													13	60					0	0	1	0	0
FNDC3A	22862	broad.mit.edu	37	13	49776048	49776048	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:49776048C>T	ENST00000492622.2	+	24	3405	c.3100C>T	c.(3100-3102)Ctc>Ttc	p.L1034F	FNDC3A_ENST00000541916.1_Missense_Mutation_p.L1034F|FNDC3A_ENST00000398316.3_Missense_Mutation_p.L978F	NM_001079673.1	NP_001073141.1	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	1034	Fibronectin type-III 8.					Golgi membrane|integral to membrane				endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|prostate(5)|skin(2)|urinary_tract(1)	41		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		GGAAGGTCCCCTCTCCCAAGA	0.348000													15	22					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2539344	2539344	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:2539344G>A	ENST00000358864.1	+	3	340	c.325G>A	c.(325-327)Gag>Aag	p.E109K		NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	109	Arg/Asp/Glu/Lys-rich (highly charged).					integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						CTCCTTCCAGGAGCGGACAGC	0.632000													6	14					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167489074	167489074	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:167489074C>T	ENST00000519204.1	+	6	1074	c.956C>T	c.(955-957)tCg>tTg	p.S319L	TENM2_ENST00000403607.2_Missense_Mutation_p.S273L|TENM2_ENST00000520394.1_Missense_Mutation_p.S208L|TENM2_ENST00000545108.1_Missense_Mutation_p.S440L|TENM2_ENST00000518659.1_Missense_Mutation_p.S440L					teneurin transmembrane protein 2																		GTGCCCTGGTCGTTGAAAAAC	0.408000													12	6					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16860305	16860305	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:16860305G>A	ENST00000524140.2	+	6	1270	c.852G>A	c.(850-852)ctG>ctA	p.L284L	NWD1_ENST00000552788.1_Silent_p.L284L|NWD1_ENST00000549814.1_Silent_p.L284L|NWD1_ENST00000523826.1_Silent_p.L78L|NWD1_ENST00000379808.3_Silent_p.L284L|NWD1_ENST00000339803.6_Silent_p.L149L	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	284							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TCCGTGAGCTGGATACGGCCG	0.597000													13	32					0	0	1	0	0
LHX9	56956	broad.mit.edu	37	1	197898345	197898345	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:197898345G>A	ENST00000367390.3	+	6	1150	c.1123G>A	c.(1123-1125)Gaa>Aaa	p.E375K	LHX9_ENST00000367387.4_Missense_Mutation_p.E384K|LHX9_ENST00000337020.2_Intron|LHX9_ENST00000367391.1_Intron|LHX9_ENST00000561173.1_Intron	NM_001014434.1	NP_001014434.1	Q9NQ69	LHX9_HUMAN	LIM homeobox 9	384					motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|skin(1)|stomach(1)	35						GGACAGCCACGAATCCGGAAG	0.418000													20	102					0	0	1	0	0
VIL1	7429	broad.mit.edu	37	2	219295453	219295453	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:219295453C>T	ENST00000248444.5	+	10	1042	c.954C>T	c.(952-954)ttC>ttT	p.F318F	VIL1_ENST00000392114.2_Silent_p.F7F|VIL1_ENST00000440053.1_Silent_p.F318F	NM_007127.2	NP_009058.2	P09327	VILI_HUMAN	villin 1	318	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCCAGAACTTCATCAAAGCCA	0.547000													45	20					0	0	1	0	0
UGT2B4	7363	broad.mit.edu	37	4	70346474	70346474	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:70346474G>A	ENST00000305107.6	-	6	1511	c.1465C>T	c.(1465-1467)Cac>Tac	p.H489Y	UGT2B4_ENST00000506580.1_5'UTR|UGT2B4_ENST00000512583.1_3'UTR|UGT2B4_ENST00000381096.3_Missense_Mutation_p.H353Y	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	489					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						TCCAAAGAGTGGTACTGGAAC	0.498000													65	54					0	0	1	0	0
GALNT15	117248	broad.mit.edu	37	3	16254193	16254193	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:16254193C>T	ENST00000339732.5	+	6	1818	c.1315C>T	c.(1315-1317)Cgc>Tgc	p.R439C	GALNT15_ENST00000437509.1_Missense_Mutation_p.R439C	NM_054110.4	NP_473451.3			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15									p.R439C(1)									GAACAGGGTTCGCATTGCTGA	0.547000													39	31					0	0	1	0	0
POLR2J4	84820	broad.mit.edu	37	7	44012813	44012813	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:44012813G>A	ENST00000427076.1	-	0	1003					NR_003655.2																						ACTCACCTGAGGGCATCCTCA	0.607000													6	9					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71218807	71218807	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:71218807G>A	ENST00000393567.2	-	3	372	c.222C>T	c.(220-222)atC>atT	p.I74I	HYDIN_ENST00000288168.10_Silent_p.I91I|HYDIN_ENST00000448691.1_Silent_p.I74I|HYDIN_ENST00000541601.1_Silent_p.I91I|HYDIN_ENST00000448089.2_Silent_p.I74I|HYDIN_ENST00000393550.2_Silent_p.I74I|HYDIN_ENST00000321489.5_Silent_p.I74I|HYDIN_ENST00000538248.1_Silent_p.I101I	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	74										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				AGAGTTCGATGATCTGTGGTC	0.468000													28	39					0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57188761	57188761	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:57188761C>T	ENST00000331162.4	-	5	631	c.361G>A	c.(361-363)Gag>Aag	p.E121K		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	121					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			TGTAATTTCTCATGTCCACAT	0.388000													37	28					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32492714	32492714	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr21:32492714G>A	ENST00000286827.3	-	29	5219	c.4748C>T	c.(4747-4749)cCc>cTc	p.P1583L	TIAM1_ENST00000541036.1_Missense_Mutation_p.P1523L	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1583					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						TTTCCTGGAGGGGGCAAAGTC	0.557000													4	12					0	0	1	0	0
CXCR2	3579	broad.mit.edu	37	2	219000148	219000148	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:219000148G>A	ENST00000318507.2	+	3	1051	c.624G>A	c.(622-624)cgG>cgA	p.R208R		NM_001557.3	NP_001548.1	P25025	CXCR2_HUMAN	chemokine (C-X-C motif) receptor 2	208					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(11)|skin(1)|stomach(1)	22						CAAACTGGCGGATGCTGTTAC	0.542000													21	108					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56515242	56515242	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:56515242G>A	ENST00000390649.3	+	2	223	c.223G>A	c.(223-225)Gaa>Aaa	p.E75K		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	75	DAPIN.					mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GCTAGACAAGGAAGAATTTCA	0.433000													19	23					0	0	1	0	0
PSG9	5678	broad.mit.edu	37	19	43771950	43771950	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:43771950G>A	ENST00000244293.7	-	2	482	c.416C>T	c.(415-417)aCc>aTc	p.T139I	PSG9_ENST00000418820.2_Missense_Mutation_p.T139I|PSG9_ENST00000596730.1_Missense_Mutation_p.T139I|PSG9_ENST00000270077.3_Missense_Mutation_p.T139I|PSG9_ENST00000593948.1_Missense_Mutation_p.T139I|PSG9_ENST00000443718.3_Missense_Mutation_p.T139I|PSG9_ENST00000291752.5_Missense_Mutation_p.T139I			Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	139	Ig-like V-type.				female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				TAAGGTGAAGGTGAAATGTCG	0.488000													35	96					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179585273	179585273	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:179585273C>T	ENST00000589042.1	-	80	23440	c.23216G>A	c.(23215-23217)cGa>cAa	p.R7739Q	TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R7422Q|TTN_ENST00000342992.6_Missense_Mutation_p.R6495Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7422	Ig-like 59.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACCTGCTTTCGATCTTTAAC	0.388000													8	22					0	0	1	0	0
OR5AK2	390181	broad.mit.edu	37	11	56756587	56756587	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:56756587G>A	ENST00000326855.2	+	1	241	c.199G>A	c.(199-201)Gct>Act	p.A67T		NM_001005323.1	NP_001005323.1	Q8NH90	O5AK2_HUMAN	olfactory receptor, family 5, subfamily AK, member 2	67					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21						ACAACATTTGGCTTTTGTTGA	0.368000													35	28					0	0	1	0	0
OR5I1	10798	broad.mit.edu	37	11	55703324	55703324	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:55703324G>A	ENST00000301532.3	-	1	552	c.553C>T	c.(553-555)Ccc>Tcc	p.P185S		NM_006637.1	NP_006628.1	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I, member 1	185					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P185A(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(34)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						TTAAGCAGGGGAGGGAGGTCA	0.403000													15	9					0	0	1	0	0
ACMSD	130013	broad.mit.edu	37	2	135596255	135596255	+	Translation_Start_Site	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:135596255G>A	ENST00000356140.5	+	1	139	c.3G>A	c.(1-3)atG>atA	p.M1I	AC016725.4_ENST00000392929.2_RNA|ACMSD_ENST00000392928.1_5'UTR|ACMSD_ENST00000283054.4_5'UTR	NM_138326.2	NP_612199.2	Q8TDX5	ACMSD_HUMAN	aminocarboxymuconate semialdehyde decarboxylase	1					quinolinate metabolic process|tryptophan catabolic process	cytosol	aminocarboxymuconate-semialdehyde decarboxylase activity|metal ion binding			endometrium(3)|large_intestine(4)|lung(6)|skin(1)	14				BRCA - Breast invasive adenocarcinoma(221;0.115)		CTGTGGAGATGAAAATTGACA	0.348000													34	15					0	0	1	0	0
APBA1	320	broad.mit.edu	37	9	72064648	72064648	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:72064648G>A	ENST00000265381.4	-	10	2255	c.2033C>T	c.(2032-2034)tCc>tTc	p.S678F		NM_001163.3	NP_001154.2	Q02410	APBA1_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 1	678	PDZ 1.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				endometrium(4)|kidney(2)|large_intestine(12)|lung(13)|prostate(3)|skin(3)	37						GGGGAGGATGGATCCCCAGCC	0.483000													15	37					0	0	1	0	0
TAS2R7	50837	broad.mit.edu	37	12	10954402	10954402	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:10954402G>A	ENST00000240687.2	-	1	824	c.768C>T	c.(766-768)tcC>tcT	p.S256S		NM_023919.2	NP_076408.1	Q9NYW3	TA2R7_HUMAN	taste receptor, type 2, member 7	256					sensory perception of taste	integral to membrane	taste receptor activity			kidney(1)|large_intestine(1)|lung(3)|skin(2)|stomach(3)	10						TAAAGTAGCTGGAGGTGGCAA	0.453000													22	28					0	0	1	0	0
LPIN1	23175	broad.mit.edu	37	2	11943103	11943103	+	Missense_Mutation	SNP	C	C	T	rs113391634		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:11943103C>T	ENST00000256720.2	+	14	1942	c.1849C>T	c.(1849-1851)Cct>Tct	p.P617S	LPIN1_ENST00000396099.1_Missense_Mutation_p.P659S|LPIN1_ENST00000404113.2_Missense_Mutation_p.P118S|LPIN1_ENST00000425416.2_Missense_Mutation_p.P623S|LPIN1_ENST00000396097.1_Missense_Mutation_p.P347S|LPIN1_ENST00000449576.2_Missense_Mutation_p.P702S	NM_145693.2	NP_663731.1	Q14693	LPIN1_HUMAN	lipin 1	617					fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(15)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	45	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		AGGCCACCTCCCTCTTCTGCC	0.542000													34	163					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111968010	111968010	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:111968010G>A	ENST00000369732.3	-	4	367	c.312C>T	c.(310-312)acC>acT	p.T104T	OVGP1_ENST00000540696.1_Silent_p.T44T	NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	104					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		CTCACCTTGAGGTGCCAAAGT	0.547000													19	10					0	0	1	0	0
PTX4	390667	broad.mit.edu	37	16	1537667	1537667	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:1537667G>A	ENST00000447419.2	-	2	471	c.446C>T	c.(445-447)gCc>gTc	p.A149V	PTX4_ENST00000440447.2_Intron|PTX4_ENST00000293922.1_Missense_Mutation_p.A144V			Q96A99	PTX4_HUMAN	pentraxin 4, long	149						extracellular region	metal ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	17						GTCCTGCAGGGCGTCCCTCTG	0.716000													20	39					0	0	1	0	0
OR2L13	284521	broad.mit.edu	37	1	248263377	248263377	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:248263377A>C	ENST00000366478.2	+	3	1037	c.700A>C	c.(700-702)Aaa>Caa	p.K234Q	OR2L13_ENST00000358120.2_Missense_Mutation_p.K234Q	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	234					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			GGAGGGGAGAAAAAAGGCCTT	0.448000													62	22					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73821044	73821044	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:73821044C>T	ENST00000342056.2	+	7	1441	c.1043C>T	c.(1042-1044)tCa>tTa	p.S348L	KCNQ5_ENST00000414165.2_Missense_Mutation_p.S348L|KCNQ5_ENST00000403813.2_Missense_Mutation_p.S348L|KCNQ5_ENST00000402622.2_Missense_Mutation_p.S348L|KCNQ5_ENST00000370392.1_Missense_Mutation_p.S348L|KCNQ5_ENST00000370398.1_Missense_Mutation_p.S348L|KCNQ5_ENST00000355635.3_Missense_Mutation_p.S348L|KCNQ5_ENST00000355194.4_Missense_Mutation_p.S348L	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	348					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		ATTCTTGGCTCAGGTTTTGCA	0.348000													15	40					0	0	1	0	0
RFX4	5992	broad.mit.edu	37	12	107080822	107080822	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:107080822G>A	ENST00000392842.1	+	6	952	c.538G>A	c.(538-540)Gaa>Aaa	p.E180K	RFX4_ENST00000357881.4_Missense_Mutation_p.E189K|RP11-144F15.1_ENST00000551505.1_Intron|RFX4_ENST00000229387.5_Missense_Mutation_p.E86K	NM_213594.2	NP_998759.1	Q33E94	RFX4_HUMAN	regulatory factor X, 4 (influences HLA class II expression)	180					transcription, DNA-dependent	nucleus	DNA binding			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(20)|pancreas(1)|upper_aerodigestive_tract(1)	35						ACTGCTGCCAGAATTTCCCAA	0.502000													40	85					0	0	1	0	0
ABCB8	11194	broad.mit.edu	37	7	150731374	150731374	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:150731374G>A	ENST00000358849.4	+	3	516	c.423G>A	c.(421-423)gcG>gcA	p.A141A	ABCB8_ENST00000498578.1_Silent_p.A141A|ABCB8_ENST00000477719.1_Silent_p.A141A|ABCB8_ENST00000542328.1_Silent_p.A53A|ABCB8_ENST00000297504.6_Silent_p.A158A|ABCB8_ENST00000477092.1_Silent_p.A141A|ABCB8_ENST00000356058.4_Silent_p.A178A|ABCB8_ENST00000493338.1_3'UTR	NM_007188.3	NP_009119.2	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 8	158						ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCTTGGGTGCGGCACTCGTGA	0.592000													12	56					0	0	1	0	0
C1QA	712	broad.mit.edu	37	1	22965503	22965503	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:22965503G>A	ENST00000374642.3	+	3	545	c.341G>A	c.(340-342)aGg>aAg	p.R114K	C1QA_ENST00000402322.1_Missense_Mutation_p.R114K	NM_015991.2	NP_057075.1	P02745	C1QA_HUMAN	complement component 1, q subcomponent, A chain	114	C1q.				cell-cell signaling|complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				autonomic_ganglia(1)|liver(1)|lung(3)|skin(1)	6		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.41e-27)|Colorectal(126;1.52e-07)|COAD - Colon adenocarcinoma(152;1.12e-05)|GBM - Glioblastoma multiforme(114;1.63e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000541)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GACCAGCCGAGGCCAGCCTTC	0.637000													3	31					0	0	1	0	0
TSPAN10	83882	broad.mit.edu	37	17	79609460	79609460	+	RNA	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:79609460C>T	ENST00000328585.4	+	0	112				TSPAN10_ENST00000572675.1_RNA	NM_031945.3	NP_114151.3	Q9H1Z9	TSN10_HUMAN	tetraspanin 10							integral to membrane				ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.175)|Lung NSC(278;0.192)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			GGAGAGGAGCCCCTTACTGTC	0.642000													47	11					0	0	1	0	0
CCDC176	80127	broad.mit.edu	37	14	74486181	74486181	+	Translation_Start_Site	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:74486181G>A	ENST00000394009.3	+	0	123				CCDC176_ENST00000489323.1_3'UTR	NM_025057.2	NP_079333.2			coiled-coil domain containing 176																		GGGAAGCCAAGATGCCGTCGA	0.632000													3	13					0	0	1	0	0
ATP7B	540	broad.mit.edu	37	13	52549114	52549114	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:52549114G>A	ENST00000242839.4	-	2	398	c.242C>T	c.(241-243)tCc>tTc	p.S81F	ATP7B_ENST00000542656.1_Missense_Mutation_p.S49F|ATP7B_ENST00000344297.5_Missense_Mutation_p.S81F|ATP7B_ENST00000448424.2_Missense_Mutation_p.S81F|ATP7B_ENST00000400370.3_Missense_Mutation_p.S81F|ATP7B_ENST00000400366.3_Missense_Mutation_p.S81F|ATP7B_ENST00000418097.2_Missense_Mutation_p.S81F	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	81	HMA 1.				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		TTTCAAATTGGAAATCCTGTC	0.517000									Wilson disease				38	28					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	43985984	43985984	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:43985984G>A	ENST00000262726.7	-	24	3255	c.3002C>T	c.(3001-3003)aCc>aTc	p.T1001I	EFCAB6_ENST00000396231.2_Missense_Mutation_p.T849I	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	1001					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				CTCCCCTTCGGTAAGAGAACA	0.413000													39	62					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121358779	121358779	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:121358779C>T	ENST00000260197.7	+	4	696	c.567C>T	c.(565-567)atC>atT	p.I189I	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	189					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		ACCTCTGGATCACGTTTGACT	0.517000													90	229					0	0	1	0	0
TGFBRAP1	9392	broad.mit.edu	37	2	105924669	105924669	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:105924669C>T	ENST00000393359.2	-	2	516	c.90G>A	c.(88-90)gtG>gtA	p.V30V	TGFBRAP1_ENST00000258449.1_Silent_p.V30V			Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor associated protein 1	30	CNH.				regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	31						CGCAGCACTCCACGCACTCTA	0.592000													21	12					0	0	1	0	0
SLC25A45	283130	broad.mit.edu	37	11	65144474	65144474	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:65144474C>T	ENST00000417511.2	-	9	1421	c.287G>A	c.(286-288)gGg>gAg	p.G96E	SLC25A45_ENST00000294187.6_Missense_Mutation_p.G96E|SLC25A45_ENST00000527174.1_Missense_Mutation_p.G138E|SLC25A45_ENST00000398802.1_Missense_Mutation_p.G138E|SLC25A45_ENST00000360662.3_Missense_Mutation_p.G114E|SLC25A45_ENST00000526432.1_Missense_Mutation_p.G76E|SLC25A45_ENST00000534028.1_Missense_Mutation_p.G114E|SLC25A45_ENST00000377152.2_Missense_Mutation_p.G34E	NM_001278251.1	NP_001265180.1	Q8N413	S2545_HUMAN	solute carrier family 25, member 45	138					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	14						TGGGGGGCTCCCTGGCTGGGC	0.657000													26	19					0	0	1	0	0
RASAL3	64926	broad.mit.edu	37	19	15564052	15564052	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:15564052G>A	ENST00000343625.6	-	15	2616	c.2536C>T	c.(2536-2538)Cca>Tca	p.P846S		NM_022904.1	NP_075055.1	Q86YV0	RASL3_HUMAN	RAS protein activator like 3	846					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|skin(1)	18						CGGGGCGCTGGTCCCATGCTC	0.736000													3	6					0	0	1	0	0
SNX30	401548	broad.mit.edu	37	9	115626678	115626678	+	Splice_Site	SNP	A	A	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:115626678A>C	ENST00000374232.3	+	8	1417	c.1254_splice	c.e8+1	p.K418_splice	SNX30_ENST00000604751.1_3'UTR	NM_001012994.1	NP_001013012.1	Q5VWJ9	SNX30_HUMAN	sorting nexin family member 30	418					cell communication|protein transport	cytoplasm	phosphatidylinositol binding			large_intestine(1)|lung(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8						TATTATGAGAAGGTAATGAGT	0.502000													5	28					0	0	1	0	0
H1FX	8971	broad.mit.edu	37	3	129034463	129034463	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:129034463C>T	ENST00000333762.4	-	1	657	c.283G>A	c.(283-285)Gcg>Acg	p.A95T	H1FX-AS1_ENST00000511998.1_RNA|H1FX-AS1_ENST00000433902.2_RNA	NM_006026.3	NP_006017.1	Q92522	H1X_HUMAN	H1 histone family, member X	95	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			kidney(1)|ovary(1)|urinary_tract(2)	4						TGCACCAGCGCCTTGATCGAG	0.632000													3	1					0	0	1	0	0
EDN3	1908	broad.mit.edu	37	20	57896098	57896098	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:57896098A>G	ENST00000311585.7	+	3	762	c.392A>G	c.(391-393)aAc>aGc	p.N131S	EDN3_ENST00000337938.2_Missense_Mutation_p.N131S|EDN3_ENST00000371025.3_Missense_Mutation_p.N131S|EDN3_ENST00000395654.3_Missense_Mutation_p.N131S|EDN3_ENST00000371028.2_Missense_Mutation_p.N131S	NM_207032.1	NP_996915.1	P14138	EDN3_HUMAN	endothelin 3	131					cell surface receptor linked signaling pathway|inositol phosphate-mediated signaling|neutrophil chemotaxis|peptide hormone secretion|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of leukocyte chemotaxis|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	extracellular space|soluble fraction	endothelin B receptor binding|hormone activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	19	all_lung(29;0.0115)					GGACTGTCCAACTACAGAGGA	0.617000													26	67					0	0	1	0	0
NIN	51199	broad.mit.edu	37	14	51239808	51239808	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:51239808G>A	ENST00000245441.5	-	8	862	c.672C>T	c.(670-672)ctC>ctT	p.L224L	NIN_ENST00000382043.4_Silent_p.L224L|NIN_ENST00000530997.2_Silent_p.L224L|NIN_ENST00000453196.1_Silent_p.L224L|NIN_ENST00000382041.3_Silent_p.L224L|NIN_ENST00000324330.9_Silent_p.L224L|NIN_ENST00000389868.3_Silent_p.L224L	NM_020921.3	NP_065972.3	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	224	EF-hand 4.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					ATACTTCCTCGAGCATCTAGA	0.363000			T	PDGFRB	MPD								25	18					0	0	1	0	0
PKP1	5317	broad.mit.edu	37	1	201293662	201293662	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:201293662C>T	ENST00000263946.3	+	11	2101	c.1850C>T	c.(1849-1851)tCc>tTc	p.S617F	PKP1_ENST00000352845.3_Missense_Mutation_p.S617F|PKP1_ENST00000367324.3_Missense_Mutation_p.S596F	NM_000299.3	NP_000290.2	Q13835	PKP1_HUMAN	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	617					cell adhesion|cellular component disassembly involved in apoptosis|multicellular organismal development	desmosome|intermediate filament|nucleus	intermediate filament binding|signal transducer activity|structural constituent of epidermis			NS(2)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(5)|prostate(1)	22						TCCGGAGCCTCCCTCCTGAGC	0.592000													7	55					0	0	1	0	0
FOLH1B	219595	broad.mit.edu	37	11	89421765	89421765	+	RNA	SNP	G	G	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:89421765G>T	ENST00000532352.1	+	0	1435							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						AAGCAAATTGGGATCTGGAAA	0.333000													33	31					4.0492e-12	4.09953e-12	1	1	0
FOXN1	8456	broad.mit.edu	37	17	26864394	26864394	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:26864394G>A	ENST00000226247.2	+	8	1916	c.1887G>A	c.(1885-1887)acG>acA	p.T629T	FOXN1_ENST00000579795.1_Silent_p.T629T	NM_003593.2	NP_003584.2	O15353	FOXN1_HUMAN	forkhead box N1	629					defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|large_intestine(3)|lung(8)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Lung NSC(42;0.00431)					CGCCCCCCACGGCCCCTGCAG	0.677000													42	4					0	0	1	0	0
ACSS1	84532	broad.mit.edu	37	20	25000665	25000665	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:25000665G>A	ENST00000537502.1	-	5	2509	c.978C>T	c.(976-978)tcC>tcT	p.S326S	ACSS1_ENST00000542618.1_Silent_p.S288S|ACSS1_ENST00000432802.2_Silent_p.S409S|ACSS1_ENST00000323482.4_Silent_p.S409S			Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	409					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	26					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GGGTCCGCAGGGAGGAGCGAT	0.582000													37	120					0	0	1	0	0
MYF6	4618	broad.mit.edu	37	12	81101782	81101782	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:81101782G>A	ENST00000228641.3	+	1	506	c.284G>A	c.(283-285)cGa>cAa	p.R95Q		NM_002469.2	NP_002460.1	P23409	MYF6_HUMAN	myogenic factor 6 (herculin)	95					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|skin(1)	26						ACTGACCGGCGAAAAGCCGCC	0.632000													20	42					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43430821	43430821	+	RNA	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:43430821C>T	ENST00000446844.3	-	0	846				PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				TCCTTATTCTCCCTGGGGTTT	0.488000													96	104					0	0	1	0	0
OC90	729330	broad.mit.edu	37	8	133047030	133047030	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:133047030G>A	ENST00000262283.5	-	14	1466	c.1367C>T	c.(1366-1368)cCa>cTa	p.P456L	OC90_ENST00000603859.1_Missense_Mutation_p.P244L|OC90_ENST00000443356.2_Missense_Mutation_p.P260L|OC90_ENST00000254627.3_Missense_Mutation_p.P244L			Q02509	OC90_HUMAN	otoconin 90	260					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			AGGCTTACCTGGAGGGGACGT	0.512000													26	74					0	0	1	0	0
RSC1A1	6248	broad.mit.edu	37	1	15987492	15987492	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:15987492G>A	ENST00000345034.1	+	1	1129	c.1129G>A	c.(1129-1131)Gaa>Aaa	p.E377K	DDI2_ENST00000480945.1_3'UTR	NM_006511.1	NP_006502.1	Q92681	RSCA1_HUMAN	regulatory solute carrier protein, family 1, member 1	377					negative regulation of transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transport	cell junction|Golgi apparatus|nucleus	ion channel inhibitor activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)	11		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00276)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TACATCTGAAGAAGTAATCTG	0.408000													10	75					0	0	1	0	0
RASGRF2	5924	broad.mit.edu	37	5	80476026	80476026	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:80476026G>A	ENST00000265080.4	+	18	2786	c.2719G>A	c.(2719-2721)Gag>Aag	p.E907K		NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	907					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		ATGTGATAAAGAGTTTATTAT	0.453000													78	27					0	0	1	0	0
MAP3K15	389840	broad.mit.edu	37	X	19428062	19428062	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:19428062G>A	ENST00000338883.4	-	12	1727	c.1728C>T	c.(1726-1728)gcC>gcT	p.A576A	MAP3K15_ENST00000359173.3_Silent_p.A11A|MAP3K15_ENST00000469203.2_Silent_p.A408A|MAP3K15_ENST00000518578.1_5'UTR	NM_001001671.3	NP_001001671.3	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase 15	576							ATP binding|MAP kinase kinase kinase activity|metal ion binding			NS(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(13)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	Hepatocellular(33;0.183)					TTATGGAAGAGGCTGTAAAAT	0.299000													13	6					0	0	1	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58549279	58549279	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:58549279C>T	ENST00000282326.1	+	3	322	c.75C>T	c.(73-75)gaC>gaT	p.D25D	ZSCAN1_ENST00000601162.1_Silent_p.D25D|ZSCAN1_ENST00000391700.1_Silent_p.D25D	NM_182572.3	NP_872378.3	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	25					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		AGGACGCAGACCCTGGGCCAG	0.701000													4	7					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109813606	109813606	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:109813606C>T	ENST00000271332.3	+	25	7602	c.7541C>T	c.(7540-7542)tCc>tTc	p.S2514F	CELSR2_ENST00000498157.1_3'UTR	NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	2514					dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		TGCTGGCTCTCCATCTATGAC	0.627000													52	287					0	0	1	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25251568	25251568	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:25251568G>A	ENST00000328086.7	-	7	3276	c.2473C>T	c.(2473-2475)Cac>Tac	p.H825Y		NM_001012981.4	NP_001012999.3	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	825					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	36				GBM - Glioblastoma multiforme(48;0.0378)		TCTCCTGTGTGGATTCTCTGG	0.443000													29	51					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47589126	47589126	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:47589126C>T	ENST00000273859.3	+	22	4113	c.3844C>T	c.(3844-3846)Cca>Tca	p.P1282S		NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	1282					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						AACTTGCAACCCACCATCCAA	0.433000													40	42					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55107724	55107724	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:55107724C>T	ENST00000251372.3	+	7	1211	c.1029C>T	c.(1027-1029)acC>acT	p.T343T	LILRB1_ENST00000418536.2_Intron|LILRA1_ENST00000473156.1_3'UTR|LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000453777.1_Intron|LILRB1_ENST00000448689.1_Intron	NM_006863.1	NP_006854.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	343	Ig-like C2-type 4.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		AGAACGTGACCCTGCTGTGTC	0.592000													21	29					0	0	1	0	0
TRIM68	55128	broad.mit.edu	37	11	4622013	4622013	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:4622013G>A	ENST00000300747.5	-	7	1240	c.951C>T	c.(949-951)atC>atT	p.I317I		NM_018073.6	NP_060543.5	Q6AZZ1	TRI68_HUMAN	tripartite motif containing 68	317	B30.2/SPRY.				protein autoubiquitination|regulation of androgen receptor signaling pathway	Golgi apparatus|nucleolus|perinuclear region of cytoplasm	androgen receptor binding|histone acetyltransferase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(4)|ovary(1)|urinary_tract(1)	15		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;9.49e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		CCTCAGACACGATGAGACGGG	0.498000													3	15					0	0	1	0	0
ITPA	3704	broad.mit.edu	37	20	3202490	3202490	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:3202490C>T	ENST00000380113.3	+	7	607	c.415C>T	c.(415-417)Cgg>Tgg	p.R139W	ITPA_ENST00000455664.1_Missense_Mutation_p.R122W|ITPA_ENST00000483354.1_3'UTR|ITPA_ENST00000399838.3_Missense_Mutation_p.R98W	NM_033453.3	NP_258412.1	Q9BY32	ITPA_HUMAN	inosine triphosphatase (nucleoside triphosphate pyrophosphatase)	139					nucleotide metabolic process	cytoplasm	metal ion binding|nucleoside-triphosphate diphosphatase activity|nucleotide binding			autonomic_ganglia(1)|large_intestine(3)|ovary(1)|stomach(1)	6						GTGGCAGGGCCGGATCGTGGC	0.582000													30	32					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179411112	179411112	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:179411112C>T	ENST00000589042.1	-	342	95170	c.94946G>A	c.(94945-94947)tGg>tAg	p.W31649*	TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Nonsense_Mutation_p.W22584*|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342175.6_Nonsense_Mutation_p.W22776*|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Nonsense_Mutation_p.W22709*|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Nonsense_Mutation_p.W30008*|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342992.6_Nonsense_Mutation_p.W29081*	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	30008							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCTTTGGTCCAGATAATTTT	0.468000													7	58					0	0	1	0	0
RNASEL	6041	broad.mit.edu	37	1	182555559	182555559	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:182555559G>A	ENST00000367559.3	-	2	636	c.383C>T	c.(382-384)gCc>gTc	p.A128V	RNASEL_ENST00000444138.1_Missense_Mutation_p.A128V|RNASEL_ENST00000539397.1_Missense_Mutation_p.A128V	NM_021133.3	NP_066956.1	Q05823	RN5A_HUMAN	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	128					mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(1)	27						TTCCATGAAGGCTGTGAAGCC	0.443000													43	23					0	0	1	0	0
LOC440700	440700	broad.mit.edu	37	1	165677878	165677878	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:165677878G>A	ENST00000400982.2	+	0	474					NR_036683.1																						GATCCCCAGGGGGCTCAGAAC	0.522000													3	25					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63174481	63174481	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:63174481C>T	ENST00000322893.7	-	11	2980	c.2712G>A	c.(2710-2712)caG>caA	p.Q904Q	KCNH5_ENST00000420622.2_3'UTR	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	904					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TCTGTAAGGCCTGCTCGGGGA	0.552000													38	97					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181686321	181686321	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:181686321C>T	ENST00000526775.1	+	11	1573	c.1408C>T	c.(1408-1410)Cgc>Tgc	p.R470C	CACNA1E_ENST00000358338.5_Missense_Mutation_p.R421C|CACNA1E_ENST00000367567.4_Missense_Mutation_p.R77C|CACNA1E_ENST00000357570.5_Missense_Mutation_p.R421C|CACNA1E_ENST00000367570.1_Missense_Mutation_p.R470C|CACNA1E_ENST00000367573.2_Missense_Mutation_p.R470C|CACNA1E_ENST00000360108.3_Missense_Mutation_p.R470C	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	470					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CATCTCCATTCGCCACATGGT	0.532000													84	30					0	0	1	0	0
LIPF	8513	broad.mit.edu	37	10	90427098	90427098	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:90427098G>A	ENST00000394375.3	+	3	187	c.74G>A	c.(73-75)gGg>gAg	p.G25E	LIPF_ENST00000355843.2_Missense_Mutation_p.G15E|LIPF_ENST00000238983.4_Missense_Mutation_p.G15E	NM_001198829.1	NP_001185758.1	P07098	LIPG_HUMAN	lipase, gastric	15					lipid catabolic process|triglyceride metabolic process	extracellular region	lipid binding|triglyceride lipase activity			NS(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(6)	13		Colorectal(252;0.0161)		Colorectal(12;3.91e-05)|COAD - Colon adenocarcinoma(12;5.43e-05)		TCTGTACTGGGGACTACACAT	0.378000													34	7					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	161007487	161007487	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:161007487C>T	ENST00000447678.1	-	26	4243	c.4123G>A	c.(4123-4125)Gaa>Aaa	p.E1375K	LPA_ENST00000316300.5_Missense_Mutation_p.E1375K	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	3883	Kringle 12.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TTACCTTCTTCAGAAGGAAGC	0.478000													13	38					0	0	1	0	0
HIF3A	64344	broad.mit.edu	37	19	46808528	46808528	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:46808528G>A	ENST00000339613.2	+	3	331	c.76G>A	c.(76-78)Gga>Aga	p.G26R	HIF3A_ENST00000525854.1_3'UTR|HIF3A_ENST00000420102.2_Intron|HIF3A_ENST00000244303.6_Intron|HIF3A_ENST00000377670.4_Missense_Mutation_p.G82R|HIF3A_ENST00000600383.1_Intron|HIF3A_ENST00000472815.1_Intron|HIF3A_ENST00000300862.3_Missense_Mutation_p.G80R			Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	82					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		GGGAGCAGGGGGAGAACCACT	0.607000													24	42					0	0	1	0	0
PTPRE	5791	broad.mit.edu	37	10	129871681	129871681	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:129871681G>A	ENST00000254667.3	+	17	1824	c.1545G>A	c.(1543-1545)tgG>tgA	p.W515*	PTPRE_ENST00000419012.2_Nonsense_Mutation_p.W515*|PTPRE_ENST00000306042.5_Nonsense_Mutation_p.W457*	NM_006504.4	NP_006495.1	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	515	Tyrosine-protein phosphatase 2.				negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	22		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				GGATGATCTGGGAATGGAAAT	0.602000													24	8					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24783481	24783481	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:24783481C>T	ENST00000376454.3	+	7	1762	c.1732C>T	c.(1732-1734)Cag>Tag	p.Q578*	KIAA1217_ENST00000376451.2_Intron|KIAA1217_ENST00000396445.1_Intron|KIAA1217_ENST00000376462.1_Nonsense_Mutation_p.Q498*|KIAA1217_ENST00000396446.1_Intron|KIAA1217_ENST00000458595.1_Intron|KIAA1217_ENST00000376452.3_Intron|KIAA1217_ENST00000307544.6_Intron|KIAA1217_ENST00000430453.2_Intron	NM_019590.3	NP_062536.2	Q5T5P2	SKT_HUMAN	KIAA1217	578					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						TGGCCTTGTTCAGTCTGCGCT	0.368000													29	9					0	0	1	0	0
STPG2	285555	broad.mit.edu	37	4	98865055	98865055	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:98865055G>A	ENST00000295268.3	-	8	1126	c.1037C>T	c.(1036-1038)cCa>cTa	p.P346L		NM_174952.2	NP_777612.1			sperm-tail PG-rich repeat containing 2																		TACCATATCTGGTACTTTCAT	0.353000													22	28					0	0	1	0	0
RB1	5925	broad.mit.edu	37	13	48955569	48955569	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:48955569C>A	ENST00000267163.4	+	17	1823	c.1685C>A	c.(1684-1686)gCa>gAa	p.A562E		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	562	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(8)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GAATCCCTTGCATGGCTCTCA	0.343000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			6	9					0.000157383	0.000158089	1	1	0
SSPO	23145	broad.mit.edu	37	7	149519047	149519047	+	RNA	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:149519047C>T	ENST00000378016.2	+	0	12851							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AGGGCCGCAGCCCCTCACCAC	0.706000													4	7					0	0	1	0	0
HNF4G	3174	broad.mit.edu	37	8	76456045	76456045	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:76456045G>A	ENST00000396423.2	+	2	212		c.e2-1		HNF4G_ENST00000354370.1_Splice_Site	NM_004133.4	NP_004124.4	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma						endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	37	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			TTTATTGACAGATAGTTCTGC	0.403000													20	27					0	0	1	0	0
SRRD	402055	broad.mit.edu	37	22	26881996	26881996	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:26881996C>T	ENST00000215917.6	+	2	231	c.217C>T	c.(217-219)Ctg>Ttg	p.L73L		NM_001013694.2	NP_001013716.2	Q9UH36	SRR1L_HUMAN	SRR1 domain containing	73					rhythmic process					endometrium(1)|large_intestine(1)|lung(1)|prostate(1)	4						CAGGAAGGACCTGTTTATCTC	0.473000													25	37					0	0	1	0	0
CDC14B	8555	broad.mit.edu	37	9	99314084	99314084	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:99314084G>A	ENST00000375241.1	-	5	942	c.491C>T	c.(490-492)cCt>cTt	p.P164L	CDC14B_ENST00000375242.3_Missense_Mutation_p.P127L|CDC14B_ENST00000375240.3_Missense_Mutation_p.P164L|CDC14B_ENST00000375236.1_Missense_Mutation_p.P164L|CDC14B_ENST00000265659.2_Missense_Mutation_p.P164L|CDC14B_ENST00000463569.1_Missense_Mutation_p.P164L	NM_003671.3|NM_033331.2	NP_003662.1|NP_201588.1	O60729	CC14B_HUMAN	cell division cycle 14B	164	A.				activation of anaphase-promoting complex activity|DNA repair|G2/M transition DNA damage checkpoint	nucleolus|nucleoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)	15		Acute lymphoblastic leukemia(62;0.0559)				TTACCTGAAAGGAATATAGGA	0.318000													27	21					0	0	1	0	0
FIBIN	387758	broad.mit.edu	37	11	27016612	27016612	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:27016612C>T	ENST00000318627.2	+	1	985	c.539C>T	c.(538-540)tCt>tTt	p.S180F		NM_203371.1	NP_976249.1	Q8TAL6	FIBIN_HUMAN	fin bud initiation factor homolog (zebrafish)	180						extracellular region|Golgi apparatus				breast(1)|endometrium(2)|lung(7)|upper_aerodigestive_tract(1)	11						CTGGACATCTCTGTGGGGCTC	0.557000													20	47					0	0	1	0	0
OR13C4	138804	broad.mit.edu	37	9	107289169	107289169	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:107289169C>T	ENST00000277216.3	-	1	321	c.322G>A	c.(322-324)Ggg>Agg	p.G108R		NM_001001919.1	NP_001001919.1	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C, member 4	108					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(2)|lung(14)|skin(1)	18						TCTGTTGACCCCATTGCAAAC	0.448000													51	47					0	0	1	0	0
MAP3K13	9175	broad.mit.edu	37	3	185146557	185146557	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:185146557C>T	ENST00000265026.3	+	2	522	c.188C>T	c.(187-189)cCc>cTc	p.P63L	MAP3K13_ENST00000535426.1_Intron|MAP3K13_ENST00000424227.1_Missense_Mutation_p.P63L|MAP3K13_ENST00000446828.1_Intron|MAP3K13_ENST00000443863.1_Intron	NM_004721.4	NP_004712.1	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase 13	63					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(1)|biliary_tract(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(13)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			GTGCACAGCCCCGTCACCACA	0.552000													6	16					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121736128	121736128	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:121736128G>A	ENST00000452319.1	+	10	1547	c.1487G>A	c.(1486-1488)cGa>cAa	p.R496Q	GLI2_ENST00000435313.2_3'UTR|GLI2_ENST00000314490.11_Missense_Mutation_p.R168Q|GLI2_ENST00000361492.4_Missense_Mutation_p.R496Q			P10070	GLI2_HUMAN	GLI family zinc finger 2	496					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				CACATGCGGCGACACACGGGC	0.652000													22	65					0	0	1	0	0
UBE2J2	118424	broad.mit.edu	37	1	1203260	1203260	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:1203260G>A	ENST00000349431.6	-	2	332	c.113C>T	c.(112-114)cCt>cTt	p.P38L	UBE2J2_ENST00000400930.4_Missense_Mutation_p.P38L|UBE2J2_ENST00000347370.2_5'UTR|UBE2J2_ENST00000348298.7_5'UTR|UBE2J2_ENST00000491779.1_Intron|UBE2J2_ENST00000360466.2_Missense_Mutation_p.P38L|UBE2J2_ENST00000400929.2_Intron	NM_058167.2	NP_477515.2	Q8N2K1	UB2J2_HUMAN	ubiquitin-conjugating enzyme E2, J2	38					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity	p.P38H(1)		cervix(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	13	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.66e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.53e-21)|Colorectal(212;0.00019)|COAD - Colon adenocarcinoma(227;0.000215)|Kidney(185;0.00255)|BRCA - Breast invasive adenocarcinoma(365;0.00266)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0371)|Lung(427;0.205)		AATATTCGAAGGGAGGGGCTC	0.632000													65	332					0	0	1	0	0
NEUROD1	4760	broad.mit.edu	37	2	182543374	182543374	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:182543374C>T	ENST00000295108.3	-	2	671	c.214G>A	c.(214-216)Gag>Aag	p.E72K	CERKL_ENST00000479558.1_Intron|NEUROD1_ENST00000496876.1_Intron	NM_002500.4	NP_002491.2	Q13562	NDF1_HUMAN	neuronal differentiation 1	72	Glu-rich (acidic).|Poly-Glu.				amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.088)			tcctcttcctcttcttcctcc	0.532000													8	26					0	0	1	0	0
LRRC4B	94030	broad.mit.edu	37	19	51021653	51021653	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:51021653C>T	ENST00000599957.1	-	3	1514	c.1317G>A	c.(1315-1317)acG>acA	p.T439T	LRRC4B_ENST00000389201.3_Silent_p.T439T			Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B	439	Ig-like C2-type.					cell junction|integral to membrane|presynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(1)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	30		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		CGGCTGAGTTCGTCACCATGC	0.706000													30	24					0	0	1	0	0
C14orf166B	145497	broad.mit.edu	37	14	77304240	77304240	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:77304240G>A	ENST00000393774.3	+	5	645	c.521G>A	c.(520-522)gGt>gAt	p.G174D	C14orf166B_ENST00000450042.2_Missense_Mutation_p.G157D|C14orf166B_ENST00000460005.1_3'UTR	NM_194287.2	NP_919263.2	Q0VAA2	CN16B_HUMAN	chromosome 14 open reading frame 166B	174										breast(1)|kidney(2)|large_intestine(3)|lung(9)|prostate(2)|skin(1)	18			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0306)		AATCACCTTGGTTTGGAGGGG	0.423000													5	5					0	0	1	0	0
MRPL21	219927	broad.mit.edu	37	11	68658813	68658813	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:68658813G>A	ENST00000362034.2	-	7	613	c.604C>T	c.(604-606)Ccg>Tcg	p.P202S	MRPL21_ENST00000450904.2_Missense_Mutation_p.P117S	NM_181514.1|NM_181515.1	NP_852615.1|NP_852616.1	Q7Z2W9	RM21_HUMAN	mitochondrial ribosomal protein L21	202					translation	mitochondrion|ribosome	RNA binding|structural constituent of ribosome			large_intestine(1)|lung(6)|prostate(1)	8			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			AACAAACACGGAGCAATCTCA	0.458000													60	51					0	0	1	0	0
SDC1	6382	broad.mit.edu	37	2	20404018	20404018	+	Silent	SNP	G	G	A	rs143685077		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:20404018G>A	ENST00000381150.1	-	4	573	c.183C>T	c.(181-183)acC>acT	p.T61T	SDC1_ENST00000403076.1_Silent_p.T61T|SDC1_ENST00000482879.1_5'UTR|SDC1_ENST00000254351.4_Silent_p.T61T	NM_001006946.1	NP_001006947.1	P18827	SDC1_HUMAN	syndecan 1	61					lipid metabolic process|lipoprotein metabolic process|myoblast development|striated muscle cell development	cytoplasm|extracellular region|focal adhesion|integral to plasma membrane	cytoskeletal protein binding|protein C-terminus binding			NS(1)|breast(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(4)|skin(2)	21	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)			OV - Ovarian serous cystadenocarcinoma(76;0.221)		AAGTGGAGGGGGTCTGCTGTG	0.617000													25	154					0	0	1	0	0
PZP	5858	broad.mit.edu	37	12	9346712	9346712	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:9346712G>A	ENST00000261336.2	-	11	1243	c.1215C>T	c.(1213-1215)atC>atT	p.I405I	PZP_ENST00000381997.2_Silent_p.I274I	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						TGGTAGTATTGATTGAAAACT	0.393000													22	37					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178579179	178579179	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:178579179C>T	ENST00000251582.7	-	10	1694	c.1593G>A	c.(1591-1593)ggG>ggA	p.G531G	ADAMTS2_ENST00000274609.5_Silent_p.G531G	NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	531	Disintegrin.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CCAAGGGGGGCCCCTTCTTGG	0.592000													11	8					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82585078	82585078	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:82585078G>A	ENST00000423517.2	-	5	5528	c.5191C>T	c.(5191-5193)Cct>Tct	p.P1731S	PCLO_ENST00000333891.8_Missense_Mutation_p.P1731S	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1662					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity	p.P1731T(2)|p.P1662T(1)		breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						ACTGATGTAGGGGATGTACCA	0.498000													46	54					0	0	1	0	0
KMT2E	55904	broad.mit.edu	37	7	104748150	104748150	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:104748150C>T	ENST00000334877.4	+	22	3780	c.3246C>T	c.(3244-3246)tcC>tcT	p.S1082S	KMT2E_ENST00000334914.7_Silent_p.S137S|KMT2E_ENST00000311117.3_Silent_p.S1082S|KMT2E_ENST00000257745.4_Silent_p.S1082S					lysine (K)-specific methyltransferase 2E																		CAGTGAACTCCAACTTGAGGG	0.512000													12	11					0	0	1	0	0
ENPP2	5168	broad.mit.edu	37	8	120629431	120629431	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:120629431G>A	ENST00000427067.2	-	7	798	c.618C>T	c.(616-618)acC>acT	p.T206T	ENPP2_ENST00000259486.6_Silent_p.T210T|ENPP2_ENST00000522826.1_Silent_p.T210T|ENPP2_ENST00000075322.6_Silent_p.T210T			Q13822	ENPP2_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 2	210					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(30)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)	69	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			AGTTAGGAAAGGTTTTAGTTG	0.403000													14	19					0	0	1	0	0
IL4R	3566	broad.mit.edu	37	16	27353522	27353522	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:27353522C>T	ENST00000395762.2	+	4	410	c.151C>T	c.(151-153)Ccc>Tcc	p.P51S	IL4R_ENST00000380922.3_Missense_Mutation_p.P36S|IL4R_ENST00000170630.2_Missense_Mutation_p.P51S|IL4R_ENST00000449195.1_Missense_Mutation_p.P51S|IL4R_ENST00000543915.2_Missense_Mutation_p.P51S	NM_000418.3	NP_000409.1	P24394	IL4RA_HUMAN	interleukin 4 receptor	51					immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	33						GATGAATGGTCCCACCAATTG	0.577000													34	57					0	0	1	0	0
ODAM	54959	broad.mit.edu	37	4	71063662	71063662	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:71063662C>T	ENST00000396094.2	+	4	211	c.163C>T	c.(163-165)Cca>Tca	p.P55S		NM_017855.3	NP_060325.3	A1E959	ODAM_HUMAN	odontogenic, ameloblast asssociated	55					biomineral tissue development|odontogenesis of dentine-containing tooth	fibril				NS(1)|breast(2)|endometrium(2)|large_intestine(2)|lung(8)|ovary(3)|skin(2)	20						TTCATGGATTCCACCTTTCTC	0.428000													64	54					0	0	1	0	0
SEPT14	346288	broad.mit.edu	37	7	55912352	55912352	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:55912352C>T	ENST00000388975.3	-	4	351	c.235G>A	c.(235-237)Gat>Aat	p.D79N	SEPT14_ENST00000477628.1_5'UTR	NM_207366.2	NP_997249.2	Q6ZU15	SEP14_HUMAN	septin 14	79					cell cycle|cell division	septin complex	GTP binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|skin(2)	23	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GATTTGTTATCTTTCAAGTTA	0.358000													30	20					0	0	1	0	0
ZNF384	171017	broad.mit.edu	37	12	6787563	6787563	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:6787563G>A	ENST00000396795.1	-	5	913	c.416C>T	c.(415-417)aCc>aTc	p.T139I	ZNF384_ENST00000396799.2_Missense_Mutation_p.T139I|ZNF384_ENST00000319770.3_Missense_Mutation_p.T123I|ZNF384_ENST00000396801.3_Missense_Mutation_p.T139I|ZNF384_ENST00000361959.3_Missense_Mutation_p.T139I|ZNF384_ENST00000355772.4_Intron			Q8TF68	ZN384_HUMAN	zinc finger protein 384	139					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/ZNF384(4)	breast(3)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(1)	18						AATGGGGAAGGTCTGAGCTGA	0.547000			T	"""EWSR1, TAF15 """	ALL								7	10					0	0	1	0	0
POLDIP3	84271	broad.mit.edu	37	22	42997984	42997984	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:42997984C>T	ENST00000252115.5	-	3	633	c.529G>A	c.(529-531)Gcc>Acc	p.A177T	POLDIP3_ENST00000339677.6_Intron|POLDIP3_ENST00000491021.1_5'UTR|POLDIP3_ENST00000451060.2_Missense_Mutation_p.A21T|POLDIP3_ENST00000348657.2_Intron	NM_032311.3	NP_115687.2	Q9BY77	PDIP3_HUMAN	polymerase (DNA-directed), delta interacting protein 3	177					positive regulation of translation	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|upper_aerodigestive_tract(1)	16						ACCTGTTTGGCCTGGTGGTTA	0.493000													39	48					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058309	11058309	+	RNA	SNP	A	A	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr21:11058309A>T	ENST00000470054.1	-	0	338									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CAAAGTGCTTACAAAATGCAC	0.393000													10	200					0	0	1	0	0
TRAV20	28663	broad.mit.edu	37	14	22509297	22509297	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:22509297G>A	ENST00000390448.3	+	0	304																											GGAAGAAAAGGAGAAAGAAAG	0.468000													17	5					0	0	1	0	0
ROBO3	64221	broad.mit.edu	37	11	124747939	124747939	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:124747939C>T	ENST00000397801.1	+	21	3285	c.3093C>T	c.(3091-3093)acC>acT	p.T1031T	ROBO3_ENST00000538940.1_Silent_p.T1009T|ROBO3_ENST00000525482.1_3'UTR|ROBO3_ENST00000543966.1_5'UTR	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	1031					axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		AGCTGCAGACCTTCCATGGGG	0.632000													11	9					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	151095855	151095855	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:151095855A>G	ENST00000474524.1	+	29	4305	c.4267A>G	c.(4267-4269)Act>Gct	p.T1423A	P2RY12_ENST00000302632.3_Intron|MED12L_ENST00000273432.4_Missense_Mutation_p.T1283A	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	1423					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CAGGTTGCCAACTTCTGTGCA	0.527000													19	35					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32711037	32711037	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:32711037C>T	ENST00000380250.3	+	11	1603	c.1107C>T	c.(1105-1107)ctC>ctT	p.L369L		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	369					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CCTGTTTGCTCTGTGTCAGTC	0.443000													27	28					0	0	1	0	0
HSD3B1	3283	broad.mit.edu	37	1	120056908	120056908	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:120056908C>T	ENST00000235547.6	+	4	907	c.768C>T	c.(766-768)taC>taT	p.Y256Y	HSD3B1_ENST00000528909.1_Silent_p.Y254Y|HSD3B1_ENST00000369413.3_Silent_p.Y254Y	NM_000862.2	NP_000853.1	P14060	3BHS1_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	254					androgen biosynthetic process|estrogen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(18)|ovary(2)|prostate(1)|skin(1)	32	all_neural(166;0.219)	all_lung(203;3.16e-06)|Lung NSC(69;2.19e-05)|all_epithelial(167;0.000624)		Lung(183;0.0106)|LUSC - Lung squamous cell carcinoma(189;0.0554)	NADH(DB00157)|Trilostane(DB01108)	GACAGTTCTACTATATCTCAG	0.522000													88	29					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38840454	38840454	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:38840454C>T	ENST00000359357.3	+	48	6736	c.6482C>T	c.(6481-6483)gCc>gTc	p.A2161V	DNAH8_ENST00000449981.2_Missense_Mutation_p.A2378V|DNAH8_ENST00000441566.1_Missense_Mutation_p.A2125V					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AATCCAAAAGCCATTACTGCA	0.443000													38	17					0	0	1	0	0
C16orf59	80178	broad.mit.edu	37	16	2514159	2514159	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:2514159C>T	ENST00000569496.1	+	9	1143	c.1084C>T	c.(1084-1086)Cag>Tag	p.Q362*	C16orf59_ENST00000361837.4_Nonsense_Mutation_p.Q362*|C16orf59_ENST00000563531.1_Nonsense_Mutation_p.Q362*|C16orf59_ENST00000483320.1_Nonsense_Mutation_p.Q195*			Q7L2K0	CP059_HUMAN	chromosome 16 open reading frame 59	362										lung(1)|skin(1)|urinary_tract(1)	3		Ovarian(90;0.17)				CTCCAGCACCCAGGAGCTGCA	0.652000													16	16					0	0	1	0	0
GPR37L1	9283	broad.mit.edu	37	1	202092431	202092431	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:202092431C>T	ENST00000367282.4	+	1	446	c.340C>T	c.(340-342)Cta>Tta	p.L114L		NM_004767.3	NP_004758.3	O60883	ETBR2_HUMAN	G protein-coupled receptor 37 like 1	114						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)	18						AGGGCAGAGGCTACAGATCCA	0.627000													10	68					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1265070	1265070	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:1265070C>T	ENST00000348261.5	+	28	5276	c.5028C>T	c.(5026-5028)ttC>ttT	p.F1676F	CACNA1H_ENST00000565831.1_Silent_p.F1670F|CACNA1H_ENST00000358590.4_Silent_p.F1670F	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	1676					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	TCCGTCGGTTCTTCAAGGACA	0.617000													10	10					0	0	1	0	0
RIC8B	55188	broad.mit.edu	37	12	107237704	107237704	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:107237704C>T	ENST00000392837.4	+	6	1291	c.1140C>T	c.(1138-1140)atC>atT	p.I380I	RIC8B_ENST00000355478.2_Silent_p.I340I|RIC8B_ENST00000549643.1_Intron|RIC8B_ENST00000392839.2_Silent_p.I380I			Q9NVN3	RIC8B_HUMAN	RIC8 guanine nucleotide exchange factor B	380					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			kidney(2)|large_intestine(5)|lung(10)|ovary(1)|urinary_tract(1)	19						ATCGAAACATCCGAAAATTTC	0.333000													13	18					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24188700	24188700	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:24188700C>G	ENST00000265769.4	+	12	1251	c.1141C>G	c.(1141-1143)Ctc>Gtc	p.L381V	ADAM28_ENST00000540823.1_Missense_Mutation_p.L148V|RP11-624C23.1_ENST00000523700.1_RNA|RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|ADAM28_ENST00000437154.2_Missense_Mutation_p.L381V|RP11-624C23.1_ENST00000518988.1_RNA|ADAM28_ENST00000518516.1_3'UTR|ADAM28_ENST00000397649.3_Missense_Mutation_p.L128V	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	381	Peptidase M12B.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		CTGCAGCCGTCTCAGCTATGA	0.383000													51	73					0	0	1	0	0
LRRC41	10489	broad.mit.edu	37	1	46763234	46763234	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:46763234C>T	ENST00000343304.6	-	3	643		c.e3+1		LRRC41_ENST00000472710.1_Splice_Site	NM_006369.4	NP_006360.3	Q15345	LRC41_HUMAN	leucine rich repeat containing 41											breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(7)|ovary(3)|pancreas(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	28	Acute lymphoblastic leukemia(166;0.155)					CCTTAACTTACTTCCAAACTG	0.468000													14	65					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197189846	197189846	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:197189846C>T	ENST00000260983.2	-	6	781	c.599G>A	c.(598-600)gGg>gAg	p.G200E	HECW2_ENST00000409111.1_Intron	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	200	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						GAAGAACATCCCTTTCTTTAG	0.502000													18	100					0	0	1	0	0
BTN2A3P	54718	broad.mit.edu	37	6	26422353	26422353	+	RNA	SNP	C	C	T	rs141013110		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:26422353C>T	ENST00000466808.2	+	0	7																		p.P3S(2)									GCTCATGGAACCAGCTGCTGC	0.622000													4	112					0	0	1	0	0
LGR6	59352	broad.mit.edu	37	1	202287272	202287272	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:202287272C>T	ENST00000367278.3	+	18	1930	c.1841C>T	c.(1840-1842)tCc>tTc	p.S614F	LGR6_ENST00000439764.2_Missense_Mutation_p.S475F|LGR6_ENST00000255432.7_Missense_Mutation_p.S562F	NM_001017403.1	NP_001017403.1	Q9HBX8	LGR6_HUMAN	leucine-rich repeat containing G protein-coupled receptor 6	614						integral to membrane|plasma membrane	protein-hormone receptor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	36						ACTGGCATTTCCTGTGGCCTT	0.637000													10	68					0	0	1	0	0
RNF217-AS1	7955	broad.mit.edu	37	6	125233676	125233676	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:125233676G>A	ENST00000439075.1	-	0	1069					NR_026876.1																						GTAATGCCAAGGGACTTACTG	0.423000													6	9					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73461501	73461501	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:73461501G>A	ENST00000377110.2	-	4	712	c.469C>T	c.(469-471)Cga>Tga	p.R157*	TRPM3_ENST00000358082.3_Nonsense_Mutation_p.R4*|TRPM3_ENST00000396285.1_Nonsense_Mutation_p.R4*|TRPM3_ENST00000396292.4_Nonsense_Mutation_p.R4*|TRPM3_ENST00000357533.2_Nonsense_Mutation_p.R159*|TRPM3_ENST00000396280.5_Nonsense_Mutation_p.R4*|TRPM3_ENST00000396283.1_Nonsense_Mutation_p.R4*|TRPM3_ENST00000360823.2_Nonsense_Mutation_p.R4*|TRPM3_ENST00000377101.1_Nonsense_Mutation_p.R4*|TRPM3_ENST00000377106.1_Nonsense_Mutation_p.R4*|TRPM3_ENST00000377111.2_Nonsense_Mutation_p.R157*|TRPM3_ENST00000423814.3_Nonsense_Mutation_p.R159*|TRPM3_ENST00000377097.3_Nonsense_Mutation_p.R4*|TRPM3_ENST00000377105.1_Nonsense_Mutation_p.R4*|TRPM3_ENST00000361823.5_Nonsense_Mutation_p.R4*|TRPM3_ENST00000408909.2_Nonsense_Mutation_p.R4*	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	157						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						AAAGATACTCGCACATACTGG	0.448000													3	28					0	0	1	0	0
PHC1	1911	broad.mit.edu	37	12	9085237	9085237	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:9085237T>A	ENST00000433083.2	+	7	1194	c.1049T>A	c.(1048-1050)aTc>aAc	p.I350N	PHC1_ENST00000433847.2_3'UTR|PHC1_ENST00000543824.1_Missense_Mutation_p.I395N|PHC1_ENST00000536844.1_Missense_Mutation_p.I174N|PHC1_ENST00000544916.1_Missense_Mutation_p.I395N			P78364	PHC1_HUMAN	polyhomeotic homolog 1 (Drosophila)	395					multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|large_intestine(8)|liver(2)|lung(3)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	27						CAGGTGGTGATCCAGCAGCAG	0.552000													14	49					0	0	1	0	0
ZNF658	26149	broad.mit.edu	37	9	40774474	40774474	+	Silent	SNP	C	C	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:40774474C>A	ENST00000602553.1	-	5	1095	c.801G>T	c.(799-801)ggG>ggT	p.G267G	ZNF658_ENST00000377626.3_Silent_p.G267G|ZNF658_ENST00000441795.1_Silent_p.G265G			Q5TYW1	ZN658_HUMAN	zinc finger protein 658	267					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		CAGAGCATTTCCCCCTTGTGT	0.358000													79	81					5.98988e-27	6.11268e-27	1	1	0
ACAA1	30	broad.mit.edu	37	3	38173449	38173449	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:38173449G>A	ENST00000333167.8	-	4	543	c.371C>T	c.(370-372)tCg>tTg	p.S124L	ACAA1_ENST00000444607.2_Missense_Mutation_p.S124L|ACAA1_ENST00000544624.1_5'UTR|ACAA1_ENST00000301810.7_Missense_Mutation_p.S124L|ACAA1_ENST00000480865.1_5'UTR|ACAA1_ENST00000450296.1_Intron	NM_001607.3	NP_001598.1	P09110	THIK_HUMAN	acetyl-CoA acyltransferase 1	124					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy	peroxisomal matrix	acetyl-CoA C-acyltransferase activity|protein binding			endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0523)|Kidney(284;0.0657)		TAGCCCCGACGAACACTGTCT	0.542000											OREG0015477	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	27					0	0	1	0	0
OCLN	100506658	broad.mit.edu	37	5	68809847	68809847	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:68809847C>T	ENST00000355237.2	+	4	1238	c.802C>T	c.(802-804)Cga>Tga	p.R268*	OCLN_ENST00000380766.2_Intron|OCLN_ENST00000538151.1_Nonsense_Mutation_p.R17*|OCLN_ENST00000396442.2_Nonsense_Mutation_p.R268*|OCLN_ENST00000542132.1_Intron	NM_002538.3	NP_002529.1	Q16625	OCLN_HUMAN	occludin	268	MARVEL.				cellular component disassembly involved in apoptosis|protein complex assembly	integral to membrane|tight junction	protein binding|structural molecule activity			endometrium(2)|large_intestine(1)|liver(1)|prostate(1)|skin(1)	6		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		TGTGAAAACTCGAAGAAAGAT	0.398000													24	6					0	0	1	0	0
MADD	8567	broad.mit.edu	37	11	47304502	47304502	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:47304502C>T	ENST00000342922.4	+	10	2201	c.1844C>T	c.(1843-1845)tCc>tTc	p.S615F	MADD_ENST00000402192.2_Missense_Mutation_p.S615F|MADD_ENST00000395336.3_Missense_Mutation_p.S615F|MADD_ENST00000406482.1_Missense_Mutation_p.S615F|MADD_ENST00000402799.1_Missense_Mutation_p.S615F|MADD_ENST00000349238.3_Missense_Mutation_p.S615F|MADD_ENST00000407859.3_Missense_Mutation_p.S615F|MADD_ENST00000395344.3_Missense_Mutation_p.S615F|MADD_ENST00000311027.5_Missense_Mutation_p.S615F	NM_130470.2	NP_569826.2	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	615					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		GACTCTGACTCCGAACCTACT	0.517000													25	28					0	0	1	0	0
TRGV8	6982	broad.mit.edu	37	7	38370122	38370122	+	RNA	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:38370122C>T	ENST00000390343.2	-	0	289																											TGGGGCCTTCCCCTCCTGGTG	0.483000													29	37					0	0	1	0	0
DGKD	8527	broad.mit.edu	37	2	234343527	234343527	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:234343527C>T	ENST00000264057.2	+	5	578	c.566C>T	c.(565-567)tCg>tTg	p.S189L	DGKD_ENST00000409813.3_Missense_Mutation_p.S145L	NM_152879.2	NP_690618.2	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa	189					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(13)|lung(15)|ovary(1)|pancreas(1)|skin(1)	38		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	GGGGTCACGTCGCACGGGCTG	0.552000													94	35					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94156490	94156490	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:94156490C>T	ENST00000553484.1	+	47	7450	c.7296C>T	c.(7294-7296)tcC>tcT	p.S2432S	UNC79_ENST00000393151.2_Silent_p.S2410S|UNC79_ENST00000555664.1_Silent_p.S2371S|UNC79_ENST00000256339.4_Silent_p.S2233S			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2410						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						AGTGTGTCTCCCATATCCGAC	0.453000													44	26					0	0	1	0	0
CASS4	57091	broad.mit.edu	37	20	55027248	55027248	+	Missense_Mutation	SNP	G	G	A	rs149703805	by1000genomes	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:55027248G>A	ENST00000371336.3	+	5	1217	c.1016G>A	c.(1015-1017)cGa>cAa	p.R339Q	CASS4_ENST00000434344.1_Intron|CASS4_ENST00000360314.3_Missense_Mutation_p.R339Q	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	339					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						CTGATTCCCCGAGTGGAACAG	0.473000													33	58					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	234112876	234112876	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:234112876C>T	ENST00000359570.5	+	28	3044	c.3044C>T	c.(3043-3045)tCc>tTc	p.1015_1015insF	INPP5D_ENST00000455936.2_Missense_Mutation_p.779_779insF|INPP5D_ENST00000450745.1_Missense_Mutation_p.779_779insF			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	0	Pro-rich.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		TCCCTGAGTTCCTTCCCTAAG	0.632000													27	29					0	0	1	0	0
PTPRU	10076	broad.mit.edu	37	1	29631876	29631876	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:29631876G>A	ENST00000373779.3	+	18	2885	c.2756G>A	c.(2755-2757)cGa>cAa	p.R919Q	PTPRU_ENST00000415600.2_3'UTR|PTPRU_ENST00000356870.3_Missense_Mutation_p.R919Q|PTPRU_ENST00000345512.3_Missense_Mutation_p.R929Q|PTPRU_ENST00000323874.8_Missense_Mutation_p.R919Q|PTPRU_ENST00000460170.2_Missense_Mutation_p.R919Q|PTPRU_ENST00000428026.2_Missense_Mutation_p.R919Q	NM_001195001.1|NM_133178.3	NP_001181930.1|NP_573439.2	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	929	Tyrosine-protein phosphatase 1.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		GATCGGCACCGAGTGAAACTG	0.567000													8	129					0	0	1	0	0
SLC16A2	6567	broad.mit.edu	37	X	73749080	73749080	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:73749080C>T	ENST00000276033.5	+	5	1591	c.1425C>T	c.(1423-1425)tcC>tcT	p.S475S	SLC16A2_ENST00000587091.1_Silent_p.S401S			P36021	MOT8_HUMAN	solute carrier family 16, member 2 (thyroid hormone transporter)	401						integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	21					Pyruvic acid(DB00119)	GCCTGATGTCCATGATGATTC	0.562000													16	2					0	0	1	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16873845	16873845	+	Silent	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:16873845A>G	ENST00000355661.3	-	7	590	c.580T>C	c.(580-582)Tta>Cta	p.L194L	PLEKHA7_ENST00000531066.1_Silent_p.L194L|PLEKHA7_ENST00000532079.1_Intron|PLEKHA7_ENST00000448080.2_Silent_p.L194L			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	194	PH.				epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						TAGTAAAATAAGCAGTAATCA	0.428000													8	55					0	0	1	0	0
C14orf37	145407	broad.mit.edu	37	14	58604962	58604962	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:58604962C>T	ENST00000267485.7	-	2	1309	c.1115G>A	c.(1114-1116)gGg>gAg	p.G372E	C14orf37_ENST00000334342.5_5'UTR	NM_001001872.2	NP_001001872.2	Q86TY3	CN037_HUMAN	chromosome 14 open reading frame 37	372						integral to membrane	binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|skin(1)	33						GTGTGTTTCCCCTTCAGGCAG	0.542000													67	74					0	0	1	0	0
CILP	8483	broad.mit.edu	37	15	65496853	65496853	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr15:65496853G>A	ENST00000261883.4	-	6	838	c.672C>T	c.(670-672)ttC>ttT	p.F224F		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	224					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix		p.F224F(1)		breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						CATGAAGCATGAAGTCCTGGC	0.597000													48	10					0	0	1	0	0
ZNF358	140467	broad.mit.edu	37	19	7584437	7584437	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:7584437C>T	ENST00000597229.1	+	2	479	c.309C>T	c.(307-309)ccC>ccT	p.P103P	ZNF358_ENST00000394341.2_Silent_p.P103P	NM_018083.4	NP_060553.4	Q9NW07	ZN358_HUMAN	zinc finger protein 358	103					embryonic forelimb morphogenesis|neural tube development|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|lung(1)|skin(2)	8						GCCCCGTACCCCTGATTCTCG	0.622000													35	91					0	0	1	0	0
FAM179A	165186	broad.mit.edu	37	2	29274876	29274876	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:29274876G>A	ENST00000379558.4	+	20	3328	c.2977G>A	c.(2977-2979)Gga>Aga	p.G993R	FAM179A_ENST00000403861.2_Missense_Mutation_p.G938R|FAM179A_ENST00000465300.1_3'UTR	NM_199280.2	NP_954974.2	Q6ZUX3	F179A_HUMAN	family with sequence similarity 179, member A	993							binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						AGAGTCCTTGGGAGGCAGCCG	0.582000													12	14					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18384658	18384658	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:18384658C>T	ENST00000441493.2	-	5	1029	c.677G>A	c.(676-678)aGg>aAg	p.R226K	MICAL3_ENST00000414725.2_Missense_Mutation_p.R226K|MICAL3_ENST00000207726.7_Missense_Mutation_p.R226K|MICAL3_ENST00000400561.2_Missense_Mutation_p.R226K|MICAL3_ENST00000585038.1_Missense_Mutation_p.R226K|MICAL3_ENST00000429452.1_Missense_Mutation_p.R226K|MICAL3_ENST00000383094.3_Missense_Mutation_p.R226K|MICAL3_ENST00000444520.1_Missense_Mutation_p.R226K	NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	226						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		CAAGGTGTTCCTCCGACCATC	0.547000													17	15					0	0	1	0	0
TLE4	7091	broad.mit.edu	37	9	82323082	82323082	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:82323082G>A	ENST00000376520.4	+	13	1910	c.1082G>A	c.(1081-1083)cGa>cAa	p.R361Q	TLE4_ENST00000265284.6_Missense_Mutation_p.R304Q|TLE4_ENST00000376534.4_5'UTR|TLE4_ENST00000376537.4_Missense_Mutation_p.R361Q|TLE4_ENST00000376544.3_Missense_Mutation_p.R260Q|TLE4_ENST00000376552.2_Missense_Mutation_p.R329Q			O60756	BCE1_HUMAN	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0										breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						CCTACTCCACGAACTGATGCG	0.438000													9	47					0	0	1	0	0
CIRH1A	84916	broad.mit.edu	37	16	69194308	69194308	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:69194308G>A	ENST00000563094.1	+	13	1528	c.1494G>A	c.(1492-1494)tgG>tgA	p.W498*	CIRH1A_ENST00000314423.7_Nonsense_Mutation_p.W498*|CIRH1A_ENST00000352319.4_Nonsense_Mutation_p.W383*			Q969X6	CIR1A_HUMAN	cirrhosis, autosomal recessive 1A (cirhin)	498						nucleolus	protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(1)	16				OV - Ovarian serous cystadenocarcinoma(108;0.125)		ATGGGAATTGGCTAGCTGCAT	0.473000													4	151					0	0	1	0	0
C7orf60	154743	broad.mit.edu	37	7	112461939	112461939	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:112461939G>A	ENST00000297145.4	-	5	1243	c.1078C>T	c.(1078-1080)Cga>Tga	p.R360*		NM_152556.2	NP_689769.2	Q1RMZ1	CG060_HUMAN	chromosome 7 open reading frame 60	360										breast(1)|endometrium(2)|lung(7)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	17						atatctGATCGAACATAGCAG	0.398000													15	16					0	0	1	0	0
SH2B3	10019	broad.mit.edu	37	12	111855964	111855964	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:111855964C>T	ENST00000341259.2	+	2	372	c.15C>T	c.(13-15)gcC>gcT	p.A5A		NM_005475.2	NP_005466.1	Q9UQQ2	SH2B3_HUMAN	SH2B adaptor protein 3	5					blood coagulation	cytosol	signal transducer activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	10						ACGGGCCTGCCCTGCAGCCCT	0.721000													17	17					0	0	1	0	0
BICD1	636	broad.mit.edu	37	12	32369310	32369310	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:32369310G>A	ENST00000548411.1	+	2	524	c.343G>A	c.(343-345)Gag>Aag	p.E115K	BICD1_ENST00000281474.5_Missense_Mutation_p.E115K	NM_001003398.1	NP_001003398.1	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 (Drosophila)	115					anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			NS(1)|breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			GATGCAGAACGAGCTGAAACA	0.512000													10	33					0	0	1	0	0
TBX20	57057	broad.mit.edu	37	7	35244195	35244195	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:35244195C>T	ENST00000408931.3	-	7	1417		c.e7-1			NM_001077653.2|NM_001166220.1	NP_001071121.1|NP_001159692.1	Q9UMR3	TBX20_HUMAN	T-box 20							nucleus	DNA binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(9)|prostate(1)|skin(1)|stomach(1)	18						CACACTTTCCCTAGGTTAGAG	0.438000													15	2					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51263126	51263126	+	Silent	SNP	C	C	T	rs139890793	by1000genomes	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:51263126C>T	ENST00000266037.9	+	15	1322	c.1299C>T	c.(1297-1299)ttC>ttT	p.F433F		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	433	DHR-1.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		AGGGGGATTTCGAGAGAGGAG	0.463000													17	47					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45303799	45303799	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:45303799G>A	ENST00000303230.4	-	6	1577	c.1520C>T	c.(1519-1521)gCc>gTc	p.A507V		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	507						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						TTTACCCACGGCTCCTTCTCG	0.403000													82	14					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186114688	186114688	+	Missense_Mutation	SNP	A	A	G	rs142044852		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:186114688A>G	ENST00000271588.4	+	92	14649	c.14420A>G	c.(14419-14421)aAc>aGc	p.N4807S	HMCN1_ENST00000367492.2_Missense_Mutation_p.N4807S	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	4807	TSP type-1 5.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CAGAGGTGCAACACTGACATG	0.517000													10	28					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138449967	138449967	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:138449967G>A	ENST00000344876.4	-	2	2881	c.2495C>T	c.(2494-2496)tCt>tTt	p.S832F	PCDH18_ENST00000412923.2_Missense_Mutation_p.S831F|PCDH18_ENST00000511115.1_Missense_Mutation_p.S12F|PCDH18_ENST00000510305.1_Missense_Mutation_p.S43F|PCDH18_ENST00000507846.1_Missense_Mutation_p.S611F	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	832					brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					AAGAAGCTGAGAGACCTGCTG	0.413000													14	50					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9067233	9067233	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:9067233C>T	ENST00000397910.4	-	3	20416	c.20213G>A	c.(20212-20214)cGa>cAa	p.R6738Q		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6740	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGGACCTGTTCGAGTGATGAT	0.502000													33	113					0	0	1	0	0
COL19A1	1310	broad.mit.edu	37	6	70890393	70890393	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:70890393C>T	ENST00000322773.4	+	44	2855	c.2753C>T	c.(2752-2754)cCa>cTa	p.P918L	COL19A1_ENST00000393344.1_Missense_Mutation_p.P540L	NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	918	Triple-helical region 5 (COL5).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						TTCCCTGGACCAGAAGGACCC	0.403000													7	49					0	0	1	0	0
AGO2	27161	broad.mit.edu	37	8	141572694	141572694	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:141572694G>A	ENST00000220592.5	-	4	488	c.376C>T	c.(376-378)Cgc>Tgc	p.R126C	AGO2_ENST00000519980.1_Missense_Mutation_p.R126C	NM_012154.3	NP_036286.2			argonaute RISC catalytic component 2																		TTGAAGATGCGATCCTTGCCT	0.602000													77	76					0	0	1	0	0
FAM221B	392307	broad.mit.edu	37	9	35825674	35825674	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:35825674G>A	ENST00000423537.2	-	2	754	c.485C>T	c.(484-486)tCc>tTc	p.S162F	TMEM8B_ENST00000377996.1_Intron	NM_001012446.3	NP_001012448.2	A6H8Z2	CI128_HUMAN	family with sequence similarity 221, member B	162										endometrium(2)|kidney(1)|lung(4)	7						TTGGACCTGGGATGAAGGGCC	0.522000											OREG0019180	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	75					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189526276	189526276	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:189526276C>T	ENST00000264731.3	+	4	629	c.540C>T	c.(538-540)tcC>tcT	p.S180S	TP63_ENST00000382063.4_Intron|TP63_ENST00000449992.1_Intron|TP63_ENST00000392463.2_Silent_p.S86S|TP63_ENST00000456148.1_Silent_p.S86S|TP63_ENST00000418709.2_Silent_p.S180S|TP63_ENST00000440651.2_Silent_p.S180S|TP63_ENST00000392461.3_Silent_p.S86S|TP63_ENST00000320472.5_Silent_p.S180S|TP63_ENST00000392460.3_Silent_p.S180S|TP63_ENST00000437221.1_Silent_p.S86S|TP63_ENST00000354600.5_Silent_p.S86S	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	180					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		TCGACGTGTCCTTCCAGCAGT	0.637000										HNSCC(45;0.13)			34	27					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58118608	58118608	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:58118608G>A	ENST00000357272.4	+	26	4629	c.4464G>A	c.(4462-4464)gaG>gaA	p.E1488E	FLNB_ENST00000295956.4_Silent_p.E1488E|FLNB_ENST00000358537.3_Silent_p.E1488E|FLNB_ENST00000348383.5_Silent_p.E1488E|FLNB_ENST00000429972.2_Silent_p.E1488E|FLNB_ENST00000419752.2_Silent_p.E1319E|FLNB_ENST00000493452.1_Silent_p.E1319E|FLNB_ENST00000490882.1_Silent_p.E1519E			O75369	FLNB_HUMAN	filamin B, beta	1488	Interaction with FBLP1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CATCTCAGGAGGGACCTTACA	0.502000													13	13					0	0	1	0	0
IGHV2-5	28457	broad.mit.edu	37	14	106494450	106494450	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:106494450G>A	ENST00000390597.2	-	0	66																											AGACCCCTGTGGAGAAAGCAT	0.527000													22	13					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74074486	74074486	+	Silent	SNP	G	G	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr18:74074486G>T	ENST00000443185.2	-	8	3776	c.3459C>A	c.(3457-3459)acC>acA	p.T1153T	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	1153					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		CTGTCTGGACGGTACCTGTGT	0.498000													7	12					0.307466	0.307466	1	1	0
PNPLA1	285848	broad.mit.edu	37	6	36259245	36259245	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:36259245G>A	ENST00000394571.2	+	2	354	c.354G>A	c.(352-354)ggG>ggA	p.G118G	PNPLA1_ENST00000312917.5_Silent_p.G23G|PNPLA1_ENST00000388715.3_Silent_p.G23G	NM_001145717.1	NP_001139189.2	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	118	Patatin.				lipid catabolic process		hydrolase activity			breast(1)|kidney(1)|large_intestine(4)|lung(9)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	22						TCACCACGGGGAAGCTCCATG	0.597000													7	29					0	0	1	0	0
MAST2	23139	broad.mit.edu	37	1	46494567	46494567	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:46494567G>T	ENST00000361297.2	+	18	2463	c.2180G>T	c.(2179-2181)gGa>gTa	p.G727V	MAST2_ENST00000372008.1_Missense_Mutation_p.G612V|MAST2_ENST00000372009.2_Missense_Mutation_p.G657V	NM_015112.2	NP_055927.2	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2	727	Protein kinase.				regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					CCTTTTTTTGGAGATACTCCG	0.547000													200	78					9.07414e-75	9.28132e-75	1	1	0
C2orf16	84226	broad.mit.edu	37	2	27800177	27800177	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:27800177G>A	ENST00000408964.2	+	1	789	c.738G>A	c.(736-738)aaG>aaA	p.K246K		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	246										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					CCCGAGTTAAGGATGTGGGGG	0.433000													64	36					0	0	1	0	0
PRKCQ	5588	broad.mit.edu	37	10	6553154	6553154	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:6553154T>A	ENST00000263125.5	-	3	220	c.121A>T	c.(121-123)Aac>Tac	p.N41Y	PRKCQ_ENST00000539722.1_5'UTR|PRKCQ_ENST00000397176.2_Missense_Mutation_p.N41Y	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	41	C2.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity	p.N41Y(1)		NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						ATCTGCCCGTTCTCTAGGAAC	0.463000													35	7					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	978050	978050	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:978050C>T	ENST00000537687.1	+	9	3801	c.3158C>T	c.(3157-3159)tCc>tTc	p.S1053F	WNK1_ENST00000530271.2_Missense_Mutation_p.S1138F|WNK1_ENST00000535572.1_Intron|WNK1_ENST00000340908.4_Intron|WNK1_ENST00000315939.6_Intron|WNK1_ENST00000574564.1_Missense_Mutation_p.S352F	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	808					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			TCCAGTGATTCCTCACAAATC	0.488000													66	48					0	0	1	0	0
C1orf50	79078	broad.mit.edu	37	1	43240423	43240423	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:43240423C>T	ENST00000372525.5	+	4	341	c.298C>T	c.(298-300)Cac>Tac	p.H100Y	C1orf50_ENST00000536543.1_5'UTR|C1orf50_ENST00000468913.2_3'UTR	NM_024097.3	NP_077002.2	Q9BV19	CA050_HUMAN	chromosome 1 open reading frame 50	100										large_intestine(2)|ovary(1)|pancreas(1)	4	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GGAAGATGCTCACAGAGATGC	0.383000													18	127					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94693336	94693336	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:94693336C>T	ENST00000282020.4	+	16	2969	c.2711C>T	c.(2710-2712)cCt>cTt	p.P904L	GRID2_ENST00000510992.1_Missense_Mutation_p.P809L	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	904					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	GATTTGACCCCTCTGGACATT	0.458000													20	59					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79461888	79461888	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:79461888G>A	ENST00000264895.6	+	74	12089	c.11649G>A	c.(11647-11649)atG>atA	p.M3883I		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3878					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						GCACCAATATGAAGTCCCTGA	0.537000													3	16					0	0	1	0	0
SLC5A4	6527	broad.mit.edu	37	22	32630983	32630983	+	Silent	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:32630983A>G	ENST00000266086.4	-	8	773	c.762T>C	c.(760-762)agT>agC	p.S254S	RP1-90G24.10_ENST00000434942.1_RNA	NM_014227.2	NP_055042.1	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (glucose activated ion channel), member 4	254					carbohydrate transport|sodium ion transport	integral to membrane	symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(15)|pancreas(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GTGTGTAGCAACTGGCACTGA	0.498000													60	106					0	0	1	0	0
TMEM184A	202915	broad.mit.edu	37	7	1586815	1586815	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:1586815G>A	ENST00000297477.5	-	9	1331	c.1015C>T	c.(1015-1017)Ccc>Tcc	p.P339S		NM_001097620.1	NP_001091089.1	Q6ZMB5	T184A_HUMAN	transmembrane protein 184A	339						integral to membrane				endometrium(1)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	12		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.88e-15)		GGTGCCGGGGGGGCTGGGGGA	0.667000													16	8					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1041590	1041590	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:1041590G>C	ENST00000263094.6	+	3	379	c.148G>C	c.(148-150)Gag>Cag	p.E50Q	ABCA7_ENST00000433129.1_Missense_Mutation_p.E50Q	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	50					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCGCCCCTGGAGCACCATGA	0.617000													26	33					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2044108	2044108	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:2044108G>A	ENST00000262113.4	+	18	2288	c.2147G>A	c.(2146-2148)gGg>gAg	p.G716E	MYOM2_ENST00000523438.1_Missense_Mutation_p.G141E	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	716	Fibronectin type-III 4.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CATCCTTATGGGATTACGCTC	0.617000													56	92					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	7812586	7812586	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:7812586C>T	ENST00000303635.7	+	21	5158	c.4951C>T	c.(4951-4953)Cgc>Tgc	p.R1651C	CAMTA1_ENST00000476864.1_Missense_Mutation_p.R215C|CAMTA1_ENST00000439411.2_Missense_Mutation_p.R1637C	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	1651					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TCGCCGCTGTCGCCACAGGTA	0.418000			T	WWTR1	epitheliod hemangioendothelioma								6	44					0	0	1	0	0
SUGP2	10147	broad.mit.edu	37	19	19112442	19112442	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:19112442G>A	ENST00000601879.1	-	8	3268	c.2971C>T	c.(2971-2973)Cgt>Tgt	p.R991C	SUGP2_ENST00000337018.6_Missense_Mutation_p.R991C|SUGP2_ENST00000456085.2_Missense_Mutation_p.R760C|SUGP2_ENST00000452918.2_Missense_Mutation_p.R991C|SUGP2_ENST00000600377.1_Missense_Mutation_p.R1005C			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	991					mRNA processing|RNA splicing	nucleus	RNA binding	p.R991C(1)		NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						GACATGGGACGACCCCGAGGC	0.423000													17	6					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40066044	40066044	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:40066044C>T	ENST00000336649.4	+	28	4214	c.4212_splice	c.e28-1	p.P1405_splice	CACNA1I_ENST00000404898.1_Splice_Site_p.P1364_splice|CACNA1I_ENST00000402142.3_Splice_Site_p.P1399_splice|CACNA1I_ENST00000401624.1_Splice_Site_p.P1399_splice|CACNA1I_ENST00000400164.3_Splice_Site_p.P1364_splice|CACNA1I_ENST00000407673.1_Splice_Site_p.P1364_splice			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	1399					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CCCCTGCAGCCTGTGACCAAC	0.582000													106	171					0	0	1	0	0
TTC7B	145567	broad.mit.edu	37	14	91007886	91007886	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:91007886G>A	ENST00000357056.2	-	21	2530	c.2409C>T	c.(2407-2409)atC>atT	p.I803I	TTC7B_ENST00000328459.6_Silent_p.I786I|TTC7B_ENST00000554654.1_5'UTR			Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	786							binding			NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	36		Melanoma(154;0.222)				CGTCCCGGAGGATCTTCTCCG	0.632000													15	17					0	0	1	0	0
CCDC9	26093	broad.mit.edu	37	19	47763920	47763920	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:47763920C>T	ENST00000221922.6	+	5	508	c.286C>T	c.(286-288)Cct>Tct	p.P96S		NM_015603.2	NP_056418.1	Q9Y3X0	CCDC9_HUMAN	coiled-coil domain containing 9	96	Gly-rich.									endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|urinary_tract(1)	12		all_cancers(25;0.0432)|all_epithelial(76;0.00812)|Medulloblastoma(540;0.0208)|all_neural(266;0.0416)|Hepatocellular(1079;0.114)		OV - Ovarian serous cystadenocarcinoma(262;8.51e-95)|Epithelial(262;1.15e-92)|all cancers(93;7.67e-84)|GBM - Glioblastoma multiforme(486;0.024)|STAD - Stomach adenocarcinoma(1328;0.183)		GGGCCGGACTCCTCCACAGCA	0.721000													22	23					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48691182	48691182	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:48691182G>A	ENST00000314191.2	-	84	11744	c.11688C>T	c.(11686-11688)ttC>ttT	p.F3896F	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Silent_p.F3865F	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	3897	PI3K/PI4K.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GGAGCGCCAGGAAAGCCTCAG	0.567000								Non-homologous end-joining					8	13					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	4494906	4494906	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:4494906G>A	ENST00000602557.1	-	2	815	c.260C>T	c.(259-261)tCa>tTa	p.S87L	CSMD1_ENST00000400186.3_Missense_Mutation_p.S87L|CSMD1_ENST00000542608.1_Missense_Mutation_p.S87L|CSMD1_ENST00000539096.1_Missense_Mutation_p.S87L|CSMD1_ENST00000602723.1_Missense_Mutation_p.S87L|CSMD1_ENST00000537824.1_Missense_Mutation_p.S87L|CSMD1_ENST00000520002.1_Missense_Mutation_p.S87L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	87	CUB 1.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ATCGTAAACTGATAAAATATC	0.378000													41	45					0	0	1	0	0
MASP1	5648	broad.mit.edu	37	3	186943126	186943126	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:186943126C>T	ENST00000337774.5	-	13	2116	c.1727G>A	c.(1726-1728)gGa>gAa	p.G576E		NM_001879.5	NP_001870.3	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	576	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		CTGCTGGGGTCCCTCAGGCAG	0.572000													15	44					0	0	1	0	0
SLAMF9	89886	broad.mit.edu	37	1	159922202	159922202	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:159922202G>A	ENST00000368093.3	-	3	630	c.514C>T	c.(514-516)Cgg>Tgg	p.R172W	SLAMF9_ENST00000368092.3_Intron|SLAMF9_ENST00000466773.1_5'UTR	NM_033438.3	NP_254273.2	Q96A28	SLAF9_HUMAN	SLAM family member 9	172	Ig-like C2-type.					integral to membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	13	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CTATCCCCCCGGGAGAGCCAG	0.577000													82	120					0	0	1	0	0
C2orf54	79919	broad.mit.edu	37	2	241831026	241831026	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:241831026G>A	ENST00000307486.8	-	2	320	c.222C>T	c.(220-222)ttC>ttT	p.F74F	C2orf54_ENST00000402775.2_Silent_p.F55F|C2orf54_ENST00000388934.4_Silent_p.F223F			Q08AI8	CB054_HUMAN	chromosome 2 open reading frame 54	223										haematopoietic_and_lymphoid_tissue(1)|lung(4)|prostate(1)	6		all_epithelial(40;3.99e-16)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)		TGCCCTCAGGGAATCCGGGCA	0.652000													23	85					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164783060	164783060	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:164783060G>A	ENST00000264382.3	-	7	858	c.796C>T	c.(796-798)Ctt>Ttt	p.L266F		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	266	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TCACCAGGAAGTTGGTCTCGA	0.294000										HNSCC(35;0.089)			9	23					0	0	1	0	0
HR	55806	broad.mit.edu	37	8	21984860	21984860	+	Silent	SNP	G	G	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:21984860G>C	ENST00000381418.4	-	3	2575	c.1095C>G	c.(1093-1095)gcC>gcG	p.A365A	HR_ENST00000312841.8_Silent_p.A365A	NM_005144.4	NP_005135.2	O43593	HAIR_HUMAN	hair growth associated	365							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	27		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		TGGGGCCAGAGGCCTTGTTCA	0.647000													72	110					0	0	1	0	0
DLK2	65989	broad.mit.edu	37	6	43420809	43420809	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:43420809C>T	ENST00000357338.3	-	4	905	c.205G>A	c.(205-207)Ggt>Agt	p.G69S	DLK2_ENST00000372485.1_Missense_Mutation_p.G69S|DLK2_ENST00000414245.1_Missense_Mutation_p.G69S|DLK2_ENST00000372488.3_Missense_Mutation_p.G69S	NM_206539.1	NP_996262.1	Q6UY11	DLK2_HUMAN	delta-like 2 homolog (Drosophila)	69	EGF-like 2.					integral to membrane	calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			TGGCAGGTACCGTGCTGGCAG	0.632000													10	30					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54803033	54803033	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:54803033T>C	ENST00000293379.4	-	4	827	c.566A>G	c.(565-567)tAt>tGt	p.Y189C	RP11-753H16.3_ENST00000550474.1_RNA|RP11-753H16.5_ENST00000552785.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	189					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						GCAGGGTGCATACTCCAGAAT	0.577000													11	33					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	21997764	21997764	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:21997764C>T	ENST00000261200.4	-	25	3181	c.3182G>A	c.(3181-3183)gGt>gAt	p.G1061D	RP11-729I10.2_ENST00000539874.1_RNA|ABCC9_ENST00000345162.2_Missense_Mutation_p.G1025D|ABCC9_ENST00000261201.4_Missense_Mutation_p.G1061D	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	1061	ABC transmembrane type-1 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AGCTGTGAGACCCATCCATTC	0.418000													18	38					0	0	1	0	0
CLCNKA	1187	broad.mit.edu	37	1	16352730	16352730	+	Silent	SNP	C	C	T	rs115351575	byFrequency	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:16352730C>T	ENST00000375692.1	+	6	614	c.486C>T	c.(484-486)ttC>ttT	p.F162F	CLCNKA_ENST00000439316.2_Silent_p.F119F|CLCNKA_ENST00000420078.1_Silent_p.F162F|CLCNKA_ENST00000464764.1_3'UTR|CLCNKA_ENST00000331433.4_Silent_p.F162F			P51800	CLCKA_HUMAN	chloride channel, voltage-sensitive Ka	162					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(1)	19		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	GCACCCTGTTCCTGGGCAAAG	0.632000													68	29					0	0	1	0	0
HPDL	84842	broad.mit.edu	37	1	45793816	45793816	+	Silent	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:45793816T>C	ENST00000334815.3	+	1	1272	c.996T>C	c.(994-996)acT>acC	p.T332T		NM_032756.2	NP_116145.1	Q96IR7	HPDL_HUMAN	4-hydroxyphenylpyruvate dioxygenase-like	332					aromatic amino acid family metabolic process		4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)	4	Acute lymphoblastic leukemia(166;0.155)					CCCTTTTTACTGAGGACACTT	0.542000													16	119					0	0	1	0	0
PARK2	5071	broad.mit.edu	37	6	162864378	162864378	+	Silent	SNP	G	G	A	rs149699346		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:162864378G>A	ENST00000366898.1	-	2	237	c.135C>T	c.(133-135)ttC>ttT	p.F45F	PARK2_ENST00000366896.1_Silent_p.F45F|PARK2_ENST00000338468.3_5'UTR|PARK2_ENST00000366894.1_5'UTR|PARK2_ENST00000366897.1_Silent_p.F45F|PARK2_ENST00000366892.1_Silent_p.F45F	NM_004562.2	NP_004553.2	O60260	PRKN2_HUMAN	parkin RBR E3 ubiquitin protein ligase	45	Ubiquitin-like.				aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		CCTTCCCTGCGAAAATCACAC	0.592000													34	36					0	0	1	0	0
LURAP1	541468	broad.mit.edu	37	1	46685847	46685847	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:46685847C>T	ENST00000371980.3	+	2	768	c.675C>T	c.(673-675)gcC>gcT	p.A225A	POMGNT1_ENST00000396420.3_5'UTR|POMGNT1_ENST00000371992.1_5'UTR	NM_001013615.2	NP_001013633.1	Q96LR2	CA190_HUMAN	leucine rich adaptor protein 1	225					positive regulation of cytokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm											GCTTCGAGGCCCACTGGTTCT	0.532000													11	82					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713782	70713782	+	RNA	SNP	A	A	G	rs114580810	by1000genomes	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:70713782A>G	ENST00000530196.1	-	0	736					NR_003951.1																						GTCACCAGCAAATTTTGGTTC	0.443000													3	77					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16257320	16257320	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:16257320C>T	ENST00000375759.3	+	11	4789	c.4585C>T	c.(4585-4587)Cgt>Tgt	p.R1529C		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	1529					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GTTTGCTTCTCGTTTTTTACA	0.383000													9	57					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7177180	7177180	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:7177180C>T	ENST00000406697.1	+	15	1920	c.1292C>T	c.(1291-1293)cCc>cTc	p.P431L	C1S_ENST00000402681.3_Missense_Mutation_p.P264L|C1S_ENST00000360817.5_Missense_Mutation_p.P431L|C1S_ENST00000328916.3_Missense_Mutation_p.P431L|C1S_ENST00000495061.1_3'UTR			P09871	C1S_HUMAN	complement component 1, s subcomponent	431					complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	CCCAGAGAACCCTTTGAAGAA	0.468000													23	66					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73405699	73405699	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:73405699C>T	ENST00000224721.6	+	12	1272	c.1267C>T	c.(1267-1269)Cca>Tca	p.P423S	CDH23_ENST00000299366.7_Missense_Mutation_p.P463S|CDH23_ENST00000461841.3_Missense_Mutation_p.P463S|CDH23_ENST00000398809.4_Missense_Mutation_p.P418S|CDH23_ENST00000398842.3_Missense_Mutation_p.P418S	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	418	Cadherin 4.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GGTGGCCATCCCACTGGACTA	0.587000													34	3					0	0	1	0	0
CCDC37	348807	broad.mit.edu	37	3	126137305	126137305	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:126137305G>A	ENST00000393425.1	+	6	525	c.426G>A	c.(424-426)aaG>aaA	p.K142K	CCDC37_ENST00000505024.1_Silent_p.K142K|CCDC37_ENST00000352312.1_Silent_p.K141K			Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	141								p.K141N(1)		NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|skin(3)	23				GBM - Glioblastoma multiforme(114;0.166)		CAGCAGAAAAGAATGTGGAGC	0.607000													30	25					0	0	1	0	0
TBX10	347853	broad.mit.edu	37	11	67402308	67402308	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:67402308G>A	ENST00000335385.3	-	3	443	c.356C>T	c.(355-357)cCc>cTc	p.P119L		NM_005995.4	NP_005986.2	O75333	TBX10_HUMAN	T-box 10	119					anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|lung(4)|ovary(1)	7						GTCGTCCAGGGGGATGAAGTC	0.622000													29	38					0	0	1	0	0
SNAPC2	6618	broad.mit.edu	37	19	7987561	7987561	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:7987561C>T	ENST00000221573.6	+	5	968	c.917C>T	c.(916-918)tCg>tTg	p.S306L	SNAPC2_ENST00000597584.1_Missense_Mutation_p.S69L	NM_003083.3	NP_003074.1	Q13487	SNPC2_HUMAN	small nuclear RNA activating complex, polypeptide 2, 45kDa	306					snRNA transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	sequence-specific DNA binding transcription factor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|urinary_tract(1)	6						GAACTGAAATCGCCTTGGCAA	0.682000													33	93					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75982509	75982509	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr15:75982509G>A	ENST00000308508.5	-	3	989	c.897C>T	c.(895-897)tcC>tcT	p.S299S		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	299	Globular or compact configuration stabilized by disulfide bonds.|Laminin G-like 2.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						ACTGGTCCACGGAGATTTCCA	0.612000													22	3					0	0	1	0	0
WRN	7486	broad.mit.edu	37	8	30958413	30958413	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:30958413G>C	ENST00000298139.5	+	18	2279	c.2030G>C	c.(2029-2031)gGg>gCg	p.G677A		NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	677	Helicase ATP-binding.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		TCTGAGTGGGGGCATGATTTT	0.408000			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				8	15					0	0	1	0	0
OR9G4	283189	broad.mit.edu	37	11	56510724	56510724	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:56510724G>A	ENST00000302957.3	-	1	563	c.564C>T	c.(562-564)atC>atT	p.I188I		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	188					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						AGTGGTCAATGATATTTTTAC	0.448000													6	25					0	0	1	0	0
DOCK10	55619	broad.mit.edu	37	2	225729787	225729787	+	Silent	SNP	C	C	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:225729787C>A	ENST00000409592.3	-	12	1370	c.1257G>T	c.(1255-1257)gtG>gtT	p.V419V	DOCK10_ENST00000258390.7_Silent_p.V425V			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	425							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		GTGCCACACTCACAAAAAAAG	0.393000													20	84					3.5997e-14	3.6527e-14	1	1	0
ABCA13	154664	broad.mit.edu	37	7	48312493	48312493	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:48312493T>A	ENST00000435803.1	+	17	3254	c.3230T>A	c.(3229-3231)aTt>aAt	p.I1077N		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	1077					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GATTTTCGTATTTCTTTATTT	0.378000													9	4					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119427481	119427481	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:119427481C>T	ENST00000369429.3	-	8	1692	c.1683G>A	c.(1681-1683)ggG>ggA	p.G561G	TBX15_ENST00000207157.3_Silent_p.G455G			Q96SF7	TBX15_HUMAN	T-box 15	561						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		TGTGCTCCATCCCTGACGGCA	0.547000													8	57					0	0	1	0	0
SLC43A3	29015	broad.mit.edu	37	11	57188447	57188447	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:57188447T>G	ENST00000395123.2	-	7	833	c.529A>C	c.(529-531)Aag>Cag	p.K177Q	SLC43A3_ENST00000529554.1_Missense_Mutation_p.K177Q|SLC43A3_ENST00000533524.1_Missense_Mutation_p.K190Q|SLC43A3_ENST00000395124.1_Missense_Mutation_p.K177Q|SLC43A3_ENST00000528098.1_5'UTR|SLC43A3_ENST00000352187.1_Missense_Mutation_p.K177Q	NM_001278201.1|NM_014096.2	NP_001265130.1|NP_054815.2	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3	177					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(10)|lung(4)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	27						ATATTTACCTTAATAATAAGG	0.443000													14	10					0	0	1	0	0
EMR1	2015	broad.mit.edu	37	19	6897288	6897288	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:6897288G>A	ENST00000312053.4	+	4	404	c.367G>A	c.(367-369)Gga>Aga	p.G123R	EMR1_ENST00000381404.4_Intron|EMR1_ENST00000450315.3_Missense_Mutation_p.G123R|EMR1_ENST00000250572.8_Missense_Mutation_p.G123R|EMR1_ENST00000601198.1_3'UTR|EMR1_ENST00000381407.5_Intron	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	123	EGF-like 2; calcium-binding (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					CTGGGTCCCAGGAAAGCCGGG	0.502000													11	17					0	0	1	0	0
MDGA1	266727	broad.mit.edu	37	6	37618062	37618062	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:37618062C>T	ENST00000434837.2	-	8	2610	c.1432G>A	c.(1432-1434)Gtg>Atg	p.V478M	MDGA1_ENST00000505425.1_Missense_Mutation_p.V478M|MDGA1_ENST00000297153.7_Missense_Mutation_p.V478M	NM_153487.3	NP_705691.1	Q8NFP4	MDGA1_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 1	478	Ig-like 5.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	38						TCCTTGTCCACGCGGGACCAG	0.716000													5	5					0	0	1	0	0
PTPRU	10076	broad.mit.edu	37	1	29581913	29581913	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:29581913C>T	ENST00000373779.3	+	2	329	c.200C>T	c.(199-201)cCc>cTc	p.P67L	PTPRU_ENST00000356870.3_Missense_Mutation_p.P67L|PTPRU_ENST00000345512.3_Missense_Mutation_p.P67L|PTPRU_ENST00000323874.8_Missense_Mutation_p.P67L|PTPRU_ENST00000460170.2_Missense_Mutation_p.P67L|PTPRU_ENST00000428026.2_Missense_Mutation_p.P67L	NM_001195001.1|NM_133178.3	NP_001181930.1|NP_573439.2	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	67	MAM.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		GCGGACCTGCCCCACGGTAAG	0.592000													16	125					0	0	1	0	0
OR4Q3	441669	broad.mit.edu	37	14	20216499	20216499	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:20216499A>G	ENST00000331723.1	+	1	913	c.913A>G	c.(913-915)Aaa>Gaa	p.K305E		NM_172194.1	NP_751944.1	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q, member 3	305					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(4)|endometrium(3)|kidney(2)|large_intestine(1)|lung(28)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GCTGAGGATAAAACCATGTGG	0.393000													32	68					0	0	1	0	0
MOGAT3	346606	broad.mit.edu	37	7	100842081	100842081	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:100842081G>A	ENST00000223114.4	-	4	485	c.319C>T	c.(319-321)Cgg>Tgg	p.R107W	MOGAT3_ENST00000379423.3_Missense_Mutation_p.R107W|MOGAT3_ENST00000440203.2_Missense_Mutation_p.R107W	NM_178176.2	NP_835470.1	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	107					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(10)|ovary(3)	22	Lung NSC(181;0.168)|all_lung(186;0.215)					ACGTAGTTCCGATCCGGGGGC	0.592000													41	31					0	0	1	0	0
UGGT1	56886	broad.mit.edu	37	2	128867287	128867287	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:128867287C>T	ENST00000375990.3	+	5	819	c.416C>T	c.(415-417)aCc>aTc	p.T139I	UGGT1_ENST00000259253.6_Missense_Mutation_p.T163I			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	163					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						GAATCTGATACCCTTGAGGCT	0.413000													45	22					0	0	1	0	0
PARP12	64761	broad.mit.edu	37	7	139724604	139724604	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:139724604C>A	ENST00000263549.3	-	12	2735	c.1862G>T	c.(1861-1863)cGg>cTg	p.R621L		NM_022750.2	NP_073587.1	Q9H0J9	PAR12_HUMAN	poly (ADP-ribose) polymerase family, member 12	621	PARP catalytic.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	19	Melanoma(164;0.0142)					CACCAGCACCCGGGCCAGGAA	0.592000													8	39					0.000274275	0.000275197	1	1	0
TDRD1	56165	broad.mit.edu	37	10	115987843	115987843	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:115987843C>T	ENST00000251864.2	+	25	3650	c.3497C>T	c.(3496-3498)aCc>aTc	p.T1166I	TDRD1_ENST00000422662.1_Missense_Mutation_p.T694I|TDRD1_ENST00000369282.1_Missense_Mutation_p.T1090I|TDRD1_ENST00000369281.2_Missense_Mutation_p.T1052I|TDRD1_ENST00000369280.1_Missense_Mutation_p.T1090I	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	1166					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		AACAATTCAACCAATCAAAAT	0.289000													7	2					0	0	1	0	0
MYO5C	55930	broad.mit.edu	37	15	52537603	52537603	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr15:52537603G>A	ENST00000261839.7	-	18	2287	c.2126C>T	c.(2125-2127)tCc>tTc	p.S709F	MYO5C_ENST00000443683.2_3'UTR	NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	709	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		ATCGCTGAAGGAAAGCTCTTG	0.498000													60	11					0	0	1	0	0
RSPH6A	81492	broad.mit.edu	37	19	46318389	46318389	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:46318389G>A	ENST00000221538.3	-	1	188	c.46C>T	c.(46-48)Ccg>Tcg	p.P16S	RSPH6A_ENST00000597055.1_Missense_Mutation_p.P16S	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	16						intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						CTCCGGCCCGGAGGCTGCTGG	0.662000													14	11					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55540310	55540310	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:55540310C>T	ENST00000220676.1	+	4	4016	c.3868C>T	c.(3868-3870)Cag>Tag	p.Q1290*		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1290					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TGGTGTGGATCAGACTTCTAT	0.408000													58	111					0	0	1	0	0
DENND1C	79958	broad.mit.edu	37	19	6479031	6479031	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:6479031G>A	ENST00000381480.2	-	5	325	c.213C>T	c.(211-213)ttC>ttT	p.F71F	DENND1C_ENST00000591030.1_5'UTR|DENND1C_ENST00000543576.1_Silent_p.F27F	NM_024898.2	NP_079174.2	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	71	UDENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(3)|large_intestine(1)|lung(3)	10						CTGTGAGGGCGAAGGTGAAAT	0.642000													20	63					0	0	1	0	0
OR6C74	254783	broad.mit.edu	37	12	55641350	55641350	+	Missense_Mutation	SNP	C	C	A	rs144439510		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:55641350C>A	ENST00000343870.4	+	1	369	c.279C>A	c.(277-279)aaC>aaA	p.N93K		NM_001005490.1	NP_001005490.1	A6NCV1	O6C74_HUMAN	olfactory receptor, family 6, subfamily C, member 74	93					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|large_intestine(3)|lung(7)|prostate(1)	12						TTTCTTACAACGATTGTGCAG	0.413000													41	128					5.44703e-19	5.53349e-19	1	1	0
KLF11	8462	broad.mit.edu	37	2	10192463	10192463	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:10192463C>T	ENST00000535335.1	+	4	1533	c.1317C>T	c.(1315-1317)tgC>tgT	p.C439C	KLF11_ENST00000305883.1_Silent_p.C456C|KLF11_ENST00000540845.1_Silent_p.C439C	NM_001177718.1	NP_001171189.1	O14901	KLF11_HUMAN	Kruppel-like factor 11	456					apoptosis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|regulation of transcription involved in S phase of mitotic cell cycle	nucleus	sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.133)|OV - Ovarian serous cystadenocarcinoma(76;0.228)		AGTTTGTGTGCCCGGTGTGTG	0.567000													24	65					0	0	1	0	0
ABLIM2	84448	broad.mit.edu	37	4	8055967	8055967	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:8055967G>A	ENST00000318888.4	-	8	912	c.41C>T	c.(40-42)tCc>tTc	p.S14F	ABLIM2_ENST00000341937.5_Missense_Mutation_p.S257F|ABLIM2_ENST00000428004.2_Missense_Mutation_p.S257F|ABLIM2_ENST00000505872.1_Missense_Mutation_p.S257F|ABLIM2_ENST00000407564.3_Missense_Mutation_p.S257F|ABLIM2_ENST00000545242.1_Missense_Mutation_p.S257F|ABLIM2_ENST00000361581.5_Missense_Mutation_p.S257F|ABLIM2_ENST00000514025.1_Missense_Mutation_p.S14F|ABLIM2_ENST00000447017.2_Missense_Mutation_p.S257F|ABLIM2_ENST00000296372.8_Missense_Mutation_p.S257F|ABLIM2_ENST00000546334.1_Missense_Mutation_p.S257F|ABLIM2_ENST00000361737.5_Missense_Mutation_p.S257F			Q6H8Q1	ABLM2_HUMAN	actin binding LIM protein family, member 2	257					axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|pancreas(3)|prostate(2)|urinary_tract(1)	25						ATGCCAGATGGAGGAACCTGT	0.522000													8	20					0	0	1	0	0
GJA8	2703	broad.mit.edu	37	1	147380211	147380211	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:147380211C>T	ENST00000240986.4	+	2	182	c.129C>T	c.(127-129)ttC>ttT	p.F43F	GJA8_ENST00000369235.1_Silent_p.F43F	NM_005267.4	NP_005258.2	P48165	CXA8_HUMAN	gap junction protein, alpha 8, 50kDa	43					cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)	37	all_hematologic(923;0.0276)					CCGCAGAGTTCGTGTGGGGGG	0.592000													18	107					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141243007	141243007	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:141243007G>A	ENST00000389484.3	-	59	10301	c.9330C>T	c.(9328-9330)atC>atT	p.I3110I		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3110					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATACTTCAATGATTCTTTTTT	0.413000										TSP Lung(27;0.18)			11	50					0	0	1	0	0
ASB5	140458	broad.mit.edu	37	4	177146478	177146478	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:177146478G>A	ENST00000296525.3	-	2	324	c.211C>T	c.(211-213)Cga>Tga	p.R71*	ASB5_ENST00000512254.1_Nonsense_Mutation_p.R18*|ASB5_ENST00000511879.1_5'UTR	NM_080874.3	NP_543150.1	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box containing 5	71					intracellular signal transduction			p.R71*(1)		endometrium(2)|kidney(1)|large_intestine(9)|lung(18)|prostate(2)|skin(2)	34		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		AGTGGTGATCGATCTGCCCAG	0.363000													22	23					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17052778	17052778	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:17052778C>T	ENST00000418129.2	+	2	2027	c.1562C>T	c.(1561-1563)tCc>tTc	p.S521F	PLCL2_ENST00000396755.2_Missense_Mutation_p.S521F|PLCL2_ENST00000432376.1_Missense_Mutation_p.S521F	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	647	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						GAAGTCTGTTCCTTTAATGAA	0.413000													38	45					0	0	1	0	0
VPS33A	65082	broad.mit.edu	37	12	122717444	122717444	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:122717444G>A	ENST00000267199.4	-	12	1624	c.1512C>T	c.(1510-1512)tcC>tcT	p.S504S	RP11-512M8.5_ENST00000535844.1_Silent_p.S465S	NM_022916.4	NP_075067.2	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33 homolog A (S. cerevisiae)	504					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	28	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		AGCCAGGCCGGGAAAGCAGCT	0.587000													19	15					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49671830	49671830	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:49671830G>A	ENST00000561648.1	-	4	1286	c.1233C>T	c.(1231-1233)tgC>tgT	p.C411C	ZNF423_ENST00000562871.1_Silent_p.C351C|ZNF423_ENST00000562520.1_Silent_p.C351C|ZNF423_ENST00000262383.2_Silent_p.C411C|ZNF423_ENST00000563137.2_Silent_p.C351C|ZNF423_ENST00000535559.1_Silent_p.C294C|ZNF423_ENST00000567169.1_Silent_p.C294C	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	411					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				AACAATAGGGGCAGCTATAGA	0.617000													32	30					0	0	1	0	0
CCDC64	92558	broad.mit.edu	37	12	120502576	120502576	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:120502576C>A	ENST00000397558.2	+	4	802	c.802C>A	c.(802-804)Cgt>Agt	p.R268S	CCDC64_ENST00000446727.2_Missense_Mutation_p.R12S	NM_207311.2	NP_997194.2	Q6ZP65	BICR1_HUMAN	coiled-coil domain containing 64	268					Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	22	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCTGGAGCATCGTCTCAGCGC	0.567000													27	84					4.87955e-14	4.94859e-14	1	1	0
C1orf94	84970	broad.mit.edu	37	1	34667734	34667734	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:34667734G>A	ENST00000488417.1	+	4	1440	c.1320G>A	c.(1318-1320)ggG>ggA	p.G440G	C1orf94_ENST00000373374.3_Silent_p.G250G	NM_001134734.1	NP_001128206.1	Q6P1W5	CA094_HUMAN	chromosome 1 open reading frame 94	250							protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				AGTACACAGGGAATGTTTTCA	0.537000													17	65					0	0	1	0	0
ITGB4	3691	broad.mit.edu	37	17	73744962	73744962	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:73744962G>A	ENST00000200181.3	+	27	3339	c.3152G>A	c.(3151-3153)gGg>gAg	p.G1051E	ITGB4_ENST00000449880.2_Missense_Mutation_p.G1051E|ITGB4_ENST00000339591.3_Missense_Mutation_p.G1051E|ITGB4_ENST00000579662.1_Missense_Mutation_p.G1051E|ITGB4_ENST00000450894.3_Missense_Mutation_p.G1051E	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	1051	Calx-beta.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			TTCCAGCCTGGGGAGGCCTGG	0.652000													9	7					0	0	1	0	0
FAM43A	131583	broad.mit.edu	37	3	194408327	194408327	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:194408327C>T	ENST00000329759.4	+	1	1706	c.772C>T	c.(772-774)Ctc>Ttc	p.L258F		NM_153690.4	NP_710157.2	Q8N2R8	FA43A_HUMAN	family with sequence similarity 43, member A	258										breast(2)|central_nervous_system(1)|lung(6)|skin(1)	10	all_cancers(143;2.04e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.147)	OV - Ovarian serous cystadenocarcinoma(49;8.37e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;1.78e-05)		CGAGGACCTGCTCGGCGAACA	0.672000													4	1					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3794898	3794898	+	Nonsense_Mutation	SNP	T	T	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:3794898T>A	ENST00000262367.5	-	23	4788	c.3979A>T	c.(3979-3981)Aag>Tag	p.K1327*	CREBBP_ENST00000382070.3_Nonsense_Mutation_p.K1289*	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1327	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		AACTTACTCTTAGCACTGAAT	0.388000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						14	16					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19473577	19473577	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:19473577C>A	ENST00000507958.1	-	15	3121	c.2131G>T	c.(2131-2133)Gat>Tat	p.D711Y	CDH18_ENST00000382275.1_Missense_Mutation_p.D711Y|CDH18_ENST00000274170.4_Missense_Mutation_p.D711Y|CDH18_ENST00000510297.1_5'UTR			Q13634	CAD18_HUMAN	cadherin 18, type 2	711					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TCCTGAACATCTATGCTTTCC	0.493000													14	55					4.3838e-07	4.41584e-07	1	1	0
HSF2	3298	broad.mit.edu	37	6	122734774	122734774	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:122734774C>T	ENST00000452194.1	+	4	622	c.435C>T	c.(433-435)tcC>tcT	p.S145S	HSF2_ENST00000368455.4_Silent_p.S145S	NM_001135564.1	NP_001129036.1	Q03933	HSF2_HUMAN	heat shock transcription factor 2	145	Hydrophobic repeat HR-A/B.				response to stress|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			large_intestine(4)|lung(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				OV - Ovarian serous cystadenocarcinoma(136;0.00371)|all cancers(137;0.0299)|GBM - Glioblastoma multiforme(226;0.0586)		CTATTGAGTCCAGGCTTTCTG	0.323000													26	22					0	0	1	0	0
ACTL9	284382	broad.mit.edu	37	19	8808646	8808646	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:8808646C>T	ENST00000324436.3	-	1	526	c.406G>A	c.(406-408)Gac>Aac	p.D136N		NM_178525.3	NP_848620.2	Q8TC94	ACTL9_HUMAN	actin-like 9	136						cytoplasm|cytoskeleton				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(15)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	36						ACTCGGAGGTCGTGCTCCAGC	0.687000													21	36					0	0	1	0	0
SMC1A	8243	broad.mit.edu	37	X	53436077	53436077	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:53436077G>A	ENST00000322213.4	-	9	1588	c.1461C>T	c.(1459-1461)gcC>gcT	p.A487A	SMC1A_ENST00000375340.6_Silent_p.A253A	NM_006306.2	NP_006297.2	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	487					cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(8)|ovary(5)|upper_aerodigestive_tract(2)	49						GGTCGATGCGGGCATCCCCTA	0.572000													20	4					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553695	140553695	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:140553695G>A	ENST00000231137.3	+	1	1453	c.1279G>A	c.(1279-1281)Ggg>Agg	p.G427R		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		427	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CACCGACTTGGGGACACCCAG	0.512000													38	22					0	0	1	0	0
SCIN	85477	broad.mit.edu	37	7	12680050	12680050	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:12680050G>A	ENST00000297029.5	+	11	1590	c.1489G>A	c.(1489-1491)Gga>Aga	p.G497R	SCIN_ENST00000519209.1_Missense_Mutation_p.G250R|SCIN_ENST00000445618.2_Missense_Mutation_p.G250R	NM_001112706.2	NP_001106177.1	Q9Y6U3	ADSV_HUMAN	scinderin	497	Ca(2+)-dependent actin binding.				actin filament capping|actin filament severing|actin nucleation|calcium ion-dependent exocytosis|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of megakaryocyte differentiation|positive regulation of secretion|regulation of chondrocyte differentiation	cell cortex|cytoskeleton	1-phosphatidylinositol binding|actin filament binding|calcium ion binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)	17				UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		TTACAAGAATGGAACATCAAA	0.488000													4	16					0	0	1	0	0
TNFRSF11B	4982	broad.mit.edu	37	8	119941138	119941138	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:119941138C>T	ENST00000297350.4	-	3	809	c.431G>A	c.(430-432)aGa>aAa	p.R144K		NM_002546.3	NP_002537.3	O00300	TR11B_HUMAN	tumor necrosis factor receptor superfamily, member 11b	144					apoptosis|skeletal system development		cytokine activity|receptor activity			breast(1)|central_nervous_system(3)|endometrium(4)|large_intestine(6)|lung(7)|prostate(3)|skin(1)	25	all_cancers(13;3.71e-26)|Lung NSC(37;1.69e-07)|Ovarian(258;0.018)|all_neural(195;0.0592)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00193)			ATCTGGACATCTTTTGCAAAC	0.428000													30	44					0	0	1	0	0
CDH5	1003	broad.mit.edu	37	16	66423333	66423333	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:66423333G>A	ENST00000341529.3	+	5	837	c.689G>A	c.(688-690)cGa>cAa	p.R230Q	CDH5_ENST00000563425.2_Missense_Mutation_p.R230Q	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	230	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		GTGGAAGCGCGAGATGCCCAG	0.562000													27	34					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41158841	41158841	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:41158841G>A	ENST00000263413.3	-	13	2167	c.1903C>T	c.(1903-1905)Ctt>Ttt	p.L635F	C6_ENST00000337836.5_Missense_Mutation_p.L635F	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	635					complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				ATCTCAGGAAGATCGACCTCT	0.398000													7	23					0	0	1	0	0
CES3	23491	broad.mit.edu	37	16	66998292	66998292	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:66998292G>C	ENST00000303334.4	+	5	664	c.593G>C	c.(592-594)gGc>gCc	p.G198A	CES3_ENST00000394037.1_Missense_Mutation_p.G198A	NM_024922.5	NP_079198.2	Q6UWW8	EST3_HUMAN	carboxylesterase 3	198						endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|ovary(3)|skin(1)	24		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0488)|Epithelial(162;0.127)		GGCAACCAGGGCTTCCTAGAT	0.587000													21	29					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39768639	39768639	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:39768639C>T	ENST00000564288.1	+	23	3455	c.2678C>T	c.(2677-2679)tCt>tTt	p.S893F	MACF1_ENST00000372915.3_Missense_Mutation_p.S898F|MACF1_ENST00000539005.1_Missense_Mutation_p.S898F|MACF1_ENST00000317713.7_Missense_Mutation_p.S898F|MACF1_ENST00000567887.1_Missense_Mutation_p.S930F|MACF1_ENST00000545844.1_Missense_Mutation_p.S898F|MACF1_ENST00000361689.2_Missense_Mutation_p.S898F|MACF1_ENST00000476350.1_3'UTR			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	898	SH3.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GAAGATAATTCTCAGCGGACC	0.433000													14	55					0	0	1	0	0
BNIP3P1	319138	broad.mit.edu	37	14	28733737	28733737	+	RNA	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:28733737C>T	ENST00000550043.1	+	0	142																											GGACTCCGATCGCCGCAGTTG	0.687000													4	10					0	0	1	0	0
FUT9	10690	broad.mit.edu	37	6	96651333	96651333	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:96651333A>G	ENST00000302103.5	+	3	628	c.302A>G	c.(301-303)aAc>aGc	p.N101S		NM_006581.3	NP_006572.2	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	101					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	34		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		TCACTGTACAACAAATCCCAT	0.488000													17	40					0	0	1	0	0
RUNDC3B	154661	broad.mit.edu	37	7	87407205	87407205	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:87407205C>T	ENST00000338056.3	+	9	1352	c.941C>T	c.(940-942)tCc>tTc	p.S314F	RUNDC3B_ENST00000493037.1_Missense_Mutation_p.S297F|RUNDC3B_ENST00000394654.3_Missense_Mutation_p.S297F	NM_001134405.1|NM_138290.2	NP_001127877.1|NP_612147.1	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B	314										breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(2)	26	Esophageal squamous(14;0.00164)					ATTGAAGATTCCGATCTGGCT	0.378000													20	18					0	0	1	0	0
DLGAP5	9787	broad.mit.edu	37	14	55637460	55637460	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:55637460G>A	ENST00000247191.2	-	11	1563	c.1347C>T	c.(1345-1347)ttC>ttT	p.F449F	DLGAP5_ENST00000395425.2_Silent_p.F449F	NM_014750.4	NP_055565.3	Q15398	DLGP5_HUMAN	discs, large (Drosophila) homolog-associated protein 5	449					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			biliary_tract(1)|breast(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	44						TGTCCCACTCGAAGCAATGTG	0.338000													33	24					0	0	1	0	0
MYH9	4627	broad.mit.edu	37	22	36684955	36684955	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:36684955G>A	ENST00000216181.5	-	33	4818	c.4588C>T	c.(4588-4590)Cta>Tta	p.L1530L		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	1530					actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						TGCTGCTCTAGGGCCCGCTTG	0.632000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				32	60					0	0	1	0	0
FCGR1A	2209	broad.mit.edu	37	1	149761663	149761663	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:149761663G>A	ENST00000369168.4	+	5	667	c.613G>A	c.(613-615)Ggg>Agg	p.G205R	RP11-196G18.21_ENST00000420462.1_RNA|HIST2H2BF_ENST00000545683.1_Intron|RP11-196G18.3_ENST00000428289.1_RNA	NM_000566.3	NP_000557.1	P12314	FCGR1_HUMAN	Fc fragment of IgG, high affinity Ia, receptor (CD64)	205	Ig-like C2-type 3.				interferon-gamma-mediated signaling pathway|phagocytosis, engulfment	integral to membrane|plasma membrane	IgG binding|receptor activity|receptor signaling protein activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)	10	Breast(34;0.0124)|all_hematologic(923;0.127)				Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Methyl aminolevulinate(DB00992)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Porfimer(DB00707)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	ACTCCTGGAGGGGAATCTGGT	0.522000													7	49					0	0	1	0	0
SLC17A7	57030	broad.mit.edu	37	19	49935843	49935843	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:49935843G>A	ENST00000221485.3	-	9	1254	c.1083C>T	c.(1081-1083)atC>atT	p.I361I	SLC17A7_ENST00000600601.1_Silent_p.I294I|SLC17A7_ENST00000543531.1_Silent_p.I349I	NM_020309.3	NP_064705.1	Q9P2U7	VGLU1_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 7	361					glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(7)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	26		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		GGAAGTCCGCGATCTGGCCGC	0.657000													20	9					0	0	1	0	0
TRIP6	7205	broad.mit.edu	37	7	100468252	100468252	+	Missense_Mutation	SNP	C	C	T	rs17855370		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:100468252C>T	ENST00000200457.4	+	6	1246	c.886C>T	c.(886-888)Ctt>Ttt	p.L296F		NM_003302.2	NP_003293.2	Q15654	TRIP6_HUMAN	thyroid hormone receptor interactor 6	296	LIM zinc-binding 1.		L -> F (in dbSNP:rs17855370).		focal adhesion assembly|positive regulation of cell migration|regulation of transcription, DNA-dependent|release of cytoplasmic sequestered NF-kappaB|transcription, DNA-dependent	cytoplasm|cytoskeleton|focal adhesion|nucleus	identical protein binding|interleukin-1 receptor binding|kinase binding|thyroid hormone receptor binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|liver(1)|lung(5)	14	Lung NSC(181;0.041)|all_lung(186;0.0581)					GGTTGTGGCCCTTGATCGCGT	0.587000													34	26					0	0	1	0	0
TRAV36DV7	28646	broad.mit.edu	37	14	22694863	22694863	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:22694863G>A	ENST00000390463.3	+	0	70																											TCTACACAGGGGTGAGCAGTG	0.448000													31	17					0	0	1	0	0
MYOF	26509	broad.mit.edu	37	10	95085655	95085655	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:95085655C>T	ENST00000371501.4	-	46	5321	c.5199G>A	c.(5197-5199)agG>agA	p.R1733R	MYOF_ENST00000371502.4_Silent_p.R1752R|MYOF_ENST00000358334.5_Silent_p.R1720R|MYOF_ENST00000485212.1_5'UTR|MYOF_ENST00000359263.4_Silent_p.R1733R			Q9NZM1	MYOF_HUMAN	myoferlin	1733					blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						GCCCCTGAGTCCTGAGGATGT	0.557000													77	17					0	0	1	0	0
ZNF652	22834	broad.mit.edu	37	17	47394241	47394241	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:47394241G>A	ENST00000362063.2	-	2	1165	c.847C>T	c.(847-849)Ctg>Ttg	p.L283L	ZNF652_ENST00000430262.2_Silent_p.L283L	NM_014897.2	NP_055712.1	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	283					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	20	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)			TCACTTTCCAGGACAAACTTC	0.463000													51	16					0	0	1	0	0
FZD1	8321	broad.mit.edu	37	7	90895446	90895446	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:90895446C>T	ENST00000287934.2	+	1	1664	c.1251C>T	c.(1249-1251)tcC>tcT	p.S417S		NM_003505.1	NP_003496.1	Q9UP38	FZD1_HUMAN	frizzled family receptor 1	417					autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			TGGCCAGCTCCATCTGGTGGG	0.607000													33	16					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43436450	43436450	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:43436450G>A	ENST00000395891.1	+	7	1198	c.593G>A	c.(592-594)gGa>gAa	p.G198E	HECW1_ENST00000471043.1_3'UTR|HECW1_ENST00000453890.1_Missense_Mutation_p.G198E	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	198	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						ACCGTCCAAGGACAAGGAAGT	0.418000													18	21					0	0	1	0	0
OSCAR	126014	broad.mit.edu	37	19	54600297	54600297	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:54600297G>A	ENST00000284648.6	-	4	422	c.225C>T	c.(223-225)ttC>ttT	p.F75F	OSCAR_ENST00000358375.4_Silent_p.F75F|OSCAR_ENST00000359649.4_Silent_p.F79F|OSCAR_ENST00000356532.3_Silent_p.F79F|OSCAR_ENST00000351806.4_Silent_p.F64F|OSCAR_ENST00000391761.1_Silent_p.F64F|OSCAR_ENST00000391760.1_Intron			Q8IYS5	OSCAR_HUMAN	osteoclast associated, immunoglobulin-like receptor	75	Ig-like 1.					extracellular region|integral to membrane|plasma membrane	receptor activity			large_intestine(1)|skin(1)	2	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)					ACACATCCCGGAAGAGAAGGG	0.592000													20	45					0	0	1	0	0
BCAN	63827	broad.mit.edu	37	1	156618407	156618407	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:156618407G>A	ENST00000329117.4	+	6	1153	c.817G>A	c.(817-819)Gca>Aca	p.A273T	BCAN_ENST00000361588.5_Missense_Mutation_p.A273T|RP11-284F21.7_ENST00000448869.1_RNA	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	273	Link 2.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					ATTGGAGGAAGCACGGGCGTA	0.612000													106	46					0	0	1	0	0
ACTG1	71	broad.mit.edu	37	17	79478295	79478295	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:79478295C>T	ENST00000575842.1	-	3	1147	c.721G>A	c.(721-723)Gag>Aag	p.E241K	ACTG1_ENST00000573283.1_Missense_Mutation_p.E241K|ACTG1_ENST00000331925.2_Missense_Mutation_p.E241K|ACTG1_ENST00000575087.1_Missense_Mutation_p.E241K			P63261	ACTG_HUMAN	actin, gamma 1	241					adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol	ATP binding|identical protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|lung(8)|ovary(2)|prostate(5)|urinary_tract(1)	29	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0547)			TCGGGCAGCTCGTAGCTCTTC	0.592000													33	80					0	0	1	0	0
FSCB	84075	broad.mit.edu	37	14	44974480	44974480	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:44974480C>T	ENST00000340446.4	-	1	2002	c.1711G>A	c.(1711-1713)Gag>Aag	p.E571K		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	571	Ala-rich.					cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		AGAGGGGCCTCTTCTATAGAA	0.517000													11	30					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119735424	119735424	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:119735424G>A	ENST00000541757.1	+	9	825	c.445G>A	c.(445-447)Gag>Aag	p.E149K	MARCO_ENST00000327097.4_Missense_Mutation_p.E227K			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	227	Collagen-like.				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						ACCCCAAGGAGAGAAGGGCAG	0.582000													3	20					0	0	1	0	0
RSF1	51773	broad.mit.edu	37	11	77387986	77387986	+	Silent	SNP	A	A	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:77387986A>T	ENST00000308488.6	-	13	3494	c.3192T>A	c.(3190-3192)tcT>tcA	p.S1064S	RSF1_ENST00000360355.2_Silent_p.S1033S|RSF1_ENST00000480887.1_Silent_p.S812S			Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	1064					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(9)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			CCAAAATAGTAGAGATGTCTT	0.463000													12	42					0	0	1	0	0
HIP1	3092	broad.mit.edu	37	7	75192297	75192297	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:75192297G>A	ENST00000336926.6	-	11	988	c.962C>T	c.(961-963)cCc>cTc	p.P321L	HIP1_ENST00000434438.2_Missense_Mutation_p.P321L	NM_005338.5	NP_005329.3	O00291	HIP1_HUMAN	huntingtin interacting protein 1	321					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						CTCGCTGTCGGGGGATGAGGC	0.572000			T	PDGFRB	CMML								7	31					0	0	1	0	0
OR8D1	283159	broad.mit.edu	37	11	124180162	124180162	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:124180162G>A	ENST00000357821.2	-	1	571	c.501C>T	c.(499-501)tcC>tcT	p.S167S		NM_001002917.1	NP_001002917.1	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D, member 1	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(1)|lung(7)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		ATTTGCAAAAGGACAGTTTCA	0.463000													11	14					0	0	1	0	0
GABRA5	2558	broad.mit.edu	37	15	27128356	27128356	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr15:27128356C>T	ENST00000335625.5	+	5	1140	c.252C>T	c.(250-252)ttC>ttT	p.F84F	GABRA5_ENST00000557449.1_Intron|GABRA5_ENST00000400081.3_Silent_p.F84F|GABRA5_ENST00000355395.5_Silent_p.F84F|GABRB3_ENST00000541819.2_Intron	NM_000810.3	NP_000801.1	P31644	GBRA5_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 5	84					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity	p.F84F(1)		NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(26)|ovary(1)|upper_aerodigestive_tract(1)	49		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TCACCAGCTTCGGCCCGGTGT	0.662000													34	7					0	0	1	0	0
KRT6A	3853	broad.mit.edu	37	12	52884422	52884422	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:52884422C>T	ENST00000330722.6	-	5	1076	c.1008G>A	c.(1006-1008)gaG>gaA	p.E336E		NM_005554.3	NP_005545.1	P02538	K2C6A_HUMAN	keratin 6A	336	Coil 2.|Rod.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	39				BRCA - Breast invasive adenocarcinoma(357;0.189)		GGGCCTTGACCTCAGCGATGA	0.577000													27	103					0	0	1	0	0
KCNJ8	3764	broad.mit.edu	37	12	21919174	21919174	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:21919174G>A	ENST00000240662.2	-	3	1103	c.758C>T	c.(757-759)cCa>cTa	p.P253L	RP11-59N23.1_ENST00000542489.1_RNA	NM_004982.3	NP_004973.1	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 8	253						voltage-gated potassium channel complex				cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28					Levosimendan(DB00922)	GCTCTCGATTGGGTTATCAAC	0.493000													10	17					0	0	1	0	0
TRIM72	493829	broad.mit.edu	37	16	31230802	31230802	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:31230802G>A	ENST00000322122.3	+	4	963	c.679G>A	c.(679-681)Gag>Aag	p.E227K		NM_001008274.3	NP_001008275.2	Q6ZMU5	TRI72_HUMAN	tripartite motif containing 72	227					exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(9)|skin(1)	15						GAAGGTCCTGGAGGAGGTGGC	0.667000													20	33					0	0	1	0	0
ZNF577	84765	broad.mit.edu	37	19	52375986	52375986	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:52375986G>A	ENST00000420592.1	-	6	2413	c.1080C>T	c.(1078-1080)tcC>tcT	p.S360S	ZNF577_ENST00000451628.2_Silent_p.S360S|ZNF577_ENST00000412216.1_Intron|ZNF577_ENST00000301399.5_Silent_p.S419S|ZNF577_ENST00000485702.1_Intron			Q9BSK1	ZN577_HUMAN	zinc finger protein 577	419					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		GGGTTCCTGAGGAAGGCATTT	0.443000													29	18					0	0	1	0	0
TDGF1	6997	broad.mit.edu	37	3	46621264	46621264	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:46621264G>A	ENST00000296145.5	+	4	992	c.259G>A	c.(259-261)Gga>Aga	p.G87R	LRRC2_ENST00000296144.3_Intron|TDGF1_ENST00000542931.1_Missense_Mutation_p.G71R	NM_003212.3	NP_003203.1	P13385	TDGF1_HUMAN	teratocarcinoma-derived growth factor 1	87	EGF-like.				activation of MAPK activity|anterior/posterior axis specification, embryo|mammary gland development|morphogenesis of a branching structure|negative regulation of apoptosis|peptidyl-serine phosphorylation|positive regulation of cell migration|positive regulation of peptidyl-tyrosine phosphorylation	anchored to membrane|cell surface|extrinsic to plasma membrane	growth factor activity			cervix(2)|endometrium(1)|kidney(1)|lung(4)	8				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		CCTGAATGGGGGAACCTGCAT	0.532000													31	62					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179612364	179612364	+	Silent	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:179612364T>C	ENST00000360870.5	-	46	14985	c.14763A>G	c.(14761-14763)aaA>aaG	p.K4921K	TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000590773.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	1048	Ig-like 29.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCTGGTGTCTTTAGTTTCAG	0.433000													8	69					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124165059	124165059	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:124165059C>T	ENST00000360013.3	+	20	3486	c.3359C>T	c.(3358-3360)aCc>aTc	p.T1120I	KALRN_ENST00000240874.3_Missense_Mutation_p.T1120I|KALRN_ENST00000460856.1_Missense_Mutation_p.T1111I	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1120					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity	p.T1120I(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						CATTTCTGGACCTTGAAGAAG	0.542000													6	25					0	0	1	0	0
STX11	8676	broad.mit.edu	37	6	144508385	144508385	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:144508385C>T	ENST00000367568.4	+	2	804	c.621C>T	c.(619-621)atC>atT	p.I207I		NM_003764.3	NP_003755.2	O75558	STX11_HUMAN	syntaxin 11	207	t-SNARE coiled-coil homology.			ARAALNEIESRHRELLRLESR -> RGPPTTRSRAATANCC AWRAA (in Ref. 2; AAC24031).	cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	12				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		TCAACGAGATCGAGAGCCGCC	0.642000									Familial Hemophagocytic Lymphohistiocytosis				15	39					0	0	1	0	0
MAPKAPK3	7867	broad.mit.edu	37	3	50683143	50683143	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:50683143C>T	ENST00000446044.1	+	9	1227	c.631C>T	c.(631-633)Cct>Tct	p.P211S	MAPKAPK3_ENST00000357955.2_Missense_Mutation_p.P211S	NM_001243926.1	NP_001230855.1	Q16644	MAPK3_HUMAN	mitogen-activated protein kinase-activated protein kinase 3	211	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity			central_nervous_system(1)|ovary(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)		CCTGGCAGCCCCTGAGGTCCT	0.612000													10	22					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123725027	123725027	+	Missense_Mutation	SNP	G	G	C	rs121909588		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:123725027G>C	ENST00000223642.1	-	36	4455	c.4426C>G	c.(4426-4428)Cga>Gga	p.R1476G		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	1476					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	ATCCGGAATCGTACACAAAGG	0.363000													41	52					0	0	1	0	0
PARVB	29780	broad.mit.edu	37	22	44514978	44514978	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:44514978G>A	ENST00000338758.6	+	4	397	c.334G>A	c.(334-336)Gag>Aag	p.E112K	PARVB_ENST00000406477.3_Missense_Mutation_p.E145K|PARVB_ENST00000404989.1_Missense_Mutation_p.E75K|PARVB_ENST00000402876.3_Missense_Mutation_p.E112K	NM_013327.4	NP_037459.2	Q9HBI1	PARVB_HUMAN	parvin, beta	112	CH 1.				cell adhesion|cell junction assembly	cytoskeleton|cytosol|focal adhesion	actin binding	p.E145*(1)		NS(1)|breast(1)|endometrium(3)|large_intestine(7)|lung(8)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	25		Ovarian(80;0.0246)|all_neural(38;0.0423)				GAAGCAGCTGGAGGAAGACCT	0.602000													35	50					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138655765	138655765	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:138655765G>A	ENST00000251691.4	+	33	5948	c.5782G>A	c.(5782-5784)Gag>Aag	p.E1928K		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	1928					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		CTGTATGGAGGAGCCTCCCAT	0.572000													28	21					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35835990	35835990	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:35835990G>A	ENST00000085219.5	+	11	2235	c.2169G>A	c.(2167-2169)gaG>gaA	p.E723E	CD22_ENST00000594250.1_Silent_p.E546E|CD22_ENST00000419549.2_Silent_p.E551E|CD22_ENST00000544992.2_Silent_p.E723E|CD22_ENST00000270311.6_Intron|CD22_ENST00000536635.2_Silent_p.E635E|CD22_ENST00000341773.6_Silent_p.E546E	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	723					cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	GGCTTCAGGAGAATTCCAGCG	0.552000													27	46					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128294275	128294275	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:128294275G>A	ENST00000368227.3	-	30	4578	c.4212C>T	c.(4210-4212)ttC>ttT	p.F1404F	PTPRK_ENST00000368215.3_Silent_p.F1386F|PTPRK_ENST00000368210.3_Silent_p.F1405F|PTPRK_ENST00000368226.4_Silent_p.F1387F|PTPRK_ENST00000368207.3_Silent_p.F1419F|PTPRK_ENST00000368213.5_Silent_p.F1393F|PTPRK_ENST00000532331.1_Silent_p.F1409F			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1386	Tyrosine-protein phosphatase 2.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		CTATAGCACAGAACATGCCAC	0.448000													16	54					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20848538	20848538	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:20848538T>C	ENST00000262715.5	-	34	4899	c.4859A>G	c.(4858-4860)tAc>tGc	p.Y1620C	TEP1_ENST00000556935.1_Missense_Mutation_p.Y1512C|TEP1_ENST00000545983.1_5'UTR	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1620					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GAGCCGGGGGTACTGGCTGAG	0.602000													64	27					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183676246	183676246	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:183676246C>T	ENST00000511685.1	+	22	4849	c.4726C>T	c.(4726-4728)Cga>Tga	p.R1576*	TENM3_ENST00000406950.2_Nonsense_Mutation_p.R1576*|TENM3_ENST00000502950.1_3'UTR					teneurin transmembrane protein 3									p.R1576*(1)									CATGCCAGTTCGAGTGGTGTC	0.408000													18	8					0	0	1	0	0
NRG1	3084	broad.mit.edu	37	8	32621854	32621854	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:32621854G>A	ENST00000338921.4	+	13	2398	c.1881G>A	c.(1879-1881)tcG>tcA	p.S627S	NRG1_ENST00000287842.3_Silent_p.S616S|NRG1_ENST00000287845.5_Silent_p.S590S|NRG1_ENST00000405005.2_Silent_p.S619S|NRG1_ENST00000519301.1_Silent_p.S569S|NRG1_ENST00000539990.1_Silent_p.S462S|NRG1_ENST00000287840.5_Silent_p.S619S|NRG1_ENST00000341377.5_3'UTR|NRG1_ENST00000356819.4_Silent_p.S624S			Q02297	NRG1_HUMAN	neuregulin 1	619					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		GCCGCTTCTCGACACAGGAAG	0.512000													21	20					0	0	1	0	0
ZSCAN30	100101467	broad.mit.edu	37	18	32844175	32844175	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr18:32844175G>A	ENST00000420878.3	-	3	597	c.142C>T	c.(142-144)Cgg>Tgg	p.R48W	ZNF397_ENST00000589420.1_Intron|ZSCAN30_ENST00000592278.1_Missense_Mutation_p.R48W|ZSCAN30_ENST00000601405.1_Intron|ZSCAN30_ENST00000333206.5_Missense_Mutation_p.R48W|ZSCAN30_ENST00000383091.2_Missense_Mutation_p.R48W|ZSCAN30_ENST00000589178.1_Missense_Mutation_p.R48W	NM_001166012.1	NP_001159484.1	Q86W11	ZSC30_HUMAN	zinc finger and SCAN domain containing 30	48	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(5)|lung(3)|urinary_tract(1)	9						AACTTCTGCCGGAATACCTCT	0.522000													17	21					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166210771	166210771	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:166210771G>A	ENST00000357398.3	+	17	3279	c.2989G>A	c.(2989-2991)Gat>Aat	p.D997N	SCN2A_ENST00000283256.6_Missense_Mutation_p.D997N|SCN2A_ENST00000375437.2_Missense_Mutation_p.D997N|SCN2A_ENST00000375427.2_Missense_Mutation_p.D997N			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	997					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	CACTGATGATGATAACGAAAT	0.388000													34	157					0	0	1	0	0
OR13G1	441933	broad.mit.edu	37	1	247835887	247835887	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:247835887A>C	ENST00000359688.2	-	1	478	c.457T>G	c.(457-459)Tcc>Gcc	p.S153A	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005487.1	NP_001005487.1	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G, member 1	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(28)|skin(2)	35	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TGCACCCAGGAATTGGTGACT	0.468000													14	65					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1261735	1261735	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:1261735T>G	ENST00000348261.5	+	24	4744	c.4496T>G	c.(4495-4497)gTg>gGg	p.V1499G	CACNA1H_ENST00000565831.1_Missense_Mutation_p.V1499G|CACNA1H_ENST00000358590.4_Missense_Mutation_p.V1499G	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	1499					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	TCGCTGTTCGTGCTGTCATCC	0.657000													23	43					0	0	1	0	0
NAP1L4	4676	broad.mit.edu	37	11	2993357	2993357	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:2993357G>T	ENST00000380542.4	-	5	430	c.290C>A	c.(289-291)gCg>gAg	p.A97E	NAP1L4_ENST00000526115.1_Missense_Mutation_p.A97E	NM_005969.3	NP_005960.1	Q99733	NP1L4_HUMAN	nucleosome assembly protein 1-like 4	97					nucleosome assembly	chromatin assembly complex|cytoplasm	unfolded protein binding			endometrium(2)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)	13		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00301)|LUSC - Lung squamous cell carcinoma(625;0.211)		CTGGTATAGCGCTGCATACTT	0.383000													30	35					5.91797e-21	6.02214e-21	1	1	0
IGHV2-5	28457	broad.mit.edu	37	14	106494423	106494423	+	RNA	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:106494423C>T	ENST00000390597.2	-	0	88																											CAGACTCCTTCAAGGTGATCT	0.532000													8	24					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195498576	195498576	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:195498576G>A	ENST00000463781.3	-	5	13648	c.13189C>T	c.(13189-13191)Ccg>Tcg	p.P4397S	MUC4_ENST00000346145.4_Missense_Mutation_p.P161S|MUC4_ENST00000475231.1_Missense_Mutation_p.P4397S|MUC4_ENST00000349607.4_Missense_Mutation_p.P110S	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1154					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TCCCAGAACGGAGCCACCAGG	0.587000													7	28					0	0	1	0	0
ABCB5	340273	broad.mit.edu	37	7	20738086	20738086	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:20738086G>A	ENST00000404938.2	+	17	2719	c.2067G>A	c.(2065-2067)tgG>tgA	p.W689*	ABCB5_ENST00000258738.6_Nonsense_Mutation_p.W244*	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	244	ABC transporter 2.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						AGCCTGAATGGCCTTTTGTGG	0.318000													28	25					0	0	1	0	0
DUXA	503835	broad.mit.edu	37	19	57666634	57666634	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:57666634C>T	ENST00000554048.2	-	5	544		c.e5+1			NM_001012729.1	NP_001012747.1	A6NLW8	DUXA_HUMAN	double homeobox A							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	17		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		AGGCTAGTTACCTTGCAGTCC	0.512000													7	18					0	0	1	0	0
UGT2B15	7366	broad.mit.edu	37	4	69535767	69535767	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:69535767G>A	ENST00000338206.5	-	1	579	c.570C>T	c.(568-570)ttC>ttT	p.F190F		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	190					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										AGGAAGGAGGGAACAGAAATC	0.363000													39	88					0	0	1	0	0
DNAH12	201625	broad.mit.edu	37	3	57494134	57494134	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:57494134C>T	ENST00000351747.2	-	7	856	c.676G>A	c.(676-678)Gtt>Att	p.V226I	DNAH12_ENST00000389536.4_Missense_Mutation_p.V226I|DNAH12_ENST00000311202.6_Missense_Mutation_p.V226I	NM_178504.4	NP_848599.3	Q6ZR08	DYH12_HUMAN	dynein, axonemal, heavy chain 12	226	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|prostate(1)|skin(1)	25						TCCAACAAAACTGTATCAGCA	0.303000													8	24					0	0	1	0	0
PIP	5304	broad.mit.edu	37	7	142832372	142832372	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:142832372G>A	ENST00000291009.3	+	2	221	c.181G>A	c.(181-183)Gaa>Aaa	p.E61K		NM_002652.2	NP_002643.1	P12273	PIP_HUMAN	prolactin-induced protein	61						extracellular region	actin binding	p.E61*(1)		NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	18	Melanoma(164;0.059)	Ovarian(593;2.82e-05)|Breast(660;0.012)		BRCA - Breast invasive adenocarcinoma(188;0.0026)|LUSC - Lung squamous cell carcinoma(290;0.0733)|Lung(243;0.08)		AGTTCAAACAGAATTGAAAGA	0.378000													8	18					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262444	140262444	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:140262444G>A	ENST00000289272.2	+	1	591	c.591G>A	c.(589-591)agG>agA	p.R197R	PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA13_ENST00000409494.1_Silent_p.R197R|PCDHA8_ENST00000531613.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGTACTGAGGAAAACACTGG	0.443000													25	12					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14537894	14537894	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr18:14537894C>T	ENST00000358970.5	-	3	715	c.716G>A	c.(715-717)gGa>gAa	p.G239E	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	239										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						AGTGGTATTTCCATACTCATC	0.383000													14	47					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126411726	126411726	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:126411726C>T	ENST00000394329.3	+	17	13762	c.13749C>T	c.(13747-13749)atC>atT	p.I4583I	FAT4_ENST00000335110.5_Silent_p.I2824I	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4583					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AACCAGATATCATTGAAAGGG	0.478000													29	21					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179391822	179391822	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:179391822C>T	ENST00000589042.1	-	363	108117	c.107893G>A	c.(107893-107895)Gat>Aat	p.D35965N	TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D26900N|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000604571.1_RNA|TTN-AS1_ENST00000592161.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D27092N|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D27025N|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D34324N|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000585625.1_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000587576.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000587568.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.D33397N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	34324							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTCCACCATCTTGTTTCTGT	0.438000													22	19					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13911546	13911546	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:13911546C>T	ENST00000265104.4	-	12	1697	c.1593G>A	c.(1591-1593)atG>atA	p.M531I		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	531	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.M531I(1)		NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GGTCAAAATCCATTTTCCGCT	0.318000									Kartagener syndrome				54	12					0	0	1	0	0
SATL1	340562	broad.mit.edu	37	X	84363957	84363957	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:84363957C>T	ENST00000509231.1	-	1	97	c.18G>A	c.(16-18)acG>acA	p.T6T	SATL1_ENST00000395409.3_5'UTR|SATL1_ENST00000332921.5_5'UTR			Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	61							N-acetyltransferase activity			NS(1)|breast(5)|endometrium(2)|large_intestine(3)|lung(13)|skin(3)|stomach(1)|urinary_tract(1)	29						TTGATTGGTTCGTGCCTGATT	0.478000											OREG0019887	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	2					0	0	1	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24254782	24254782	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:24254782G>A	ENST00000538205.1	+	7	750		c.e7-1		ADAMDEC1_ENST00000256412.4_Splice_Site|RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|ADAMDEC1_ENST00000522298.1_Splice_Site	NM_001145271.1	NP_001138743.1	O15204	ADEC1_HUMAN	ADAM-like, decysin 1						integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		ATATCTCCCAGAGGATACTTC	0.418000													23	36					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	101092508	101092508	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:101092508C>T	ENST00000360863.6	-	4	387	c.193G>A	c.(193-195)Gaa>Aaa	p.E65K	RGS22_ENST00000523437.1_Missense_Mutation_p.E65K|RGS22_ENST00000523287.1_5'UTR	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	65					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			AGTTGTTTTTCCAGAAATTGT	0.323000													14	20					0	0	1	0	0
MAGEC3	139081	broad.mit.edu	37	X	140983188	140983188	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:140983188C>T	ENST00000298296.1	+	5	1043	c.1043C>T	c.(1042-1044)cCt>cTt	p.P348L	MAGEC3_ENST00000443323.2_Intron|MAGEC3_ENST00000483584.1_3'UTR|MAGEC3_ENST00000536088.1_Intron|MAGEC3_ENST00000544766.1_5'UTR|MAGEC3_ENST00000448920.1_Missense_Mutation_p.P100L	NM_138702.1	NP_619647.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	348	MAGE 1.									NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					CTGGCCAATCCTCAAGGTAAG	0.577000													44	15					0	0	1	0	0
FBLN7	129804	broad.mit.edu	37	2	112945098	112945098	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:112945098A>T	ENST00000409903.1	+	8	1312	c.1082A>T	c.(1081-1083)cAc>cTc	p.H361L	FBLN7_ENST00000331203.2_3'UTR|FBLN7_ENST00000409450.3_3'UTR|FBLN7_ENST00000409667.3_3'UTR			Q53RD9	FBLN7_HUMAN	fibulin 7	0					cell adhesion	proteinaceous extracellular matrix	calcium ion binding|heparin binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17						ACACAGGGGCACTGGGGTGTG	0.602000													21	122					0	0	1	0	0
ZNF670	93474	broad.mit.edu	37	1	247201497	247201497	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:247201497G>A	ENST00000366503.2	-	4	582	c.424C>T	c.(424-426)Cat>Tat	p.H142Y		NM_001204220.1|NM_033213.4	NP_001191149.1|NP_149990.1	Q9BS34	ZN670_HUMAN	zinc finger protein 670	142					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	17	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00427)			TGTTTGCAATGATATAACTTC	0.413000													14	149					0	0	1	0	0
PADI3	51702	broad.mit.edu	37	1	17593285	17593285	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:17593285C>T	ENST00000375460.3	+	5	520	c.480C>T	c.(478-480)agC>agT	p.S160S		NM_016233.2	NP_057317.2	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	160					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|liver(2)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	ATGATCCGAGCTGTGATGTCC	0.597000													105	32					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43227287	43227287	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:43227287G>A	ENST00000259750.4	+	12	1350	c.1267G>A	c.(1267-1269)Gaa>Aaa	p.E423K	TTBK1_ENST00000304139.5_Missense_Mutation_p.E372K	NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	423						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			TGTGGAGGAGGAACAGAGCCG	0.667000													20	8					0	0	1	0	0
ECH1	1891	broad.mit.edu	37	19	39308180	39308180	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:39308180G>A	ENST00000221418.4	-	4	617	c.385C>T	c.(385-387)Cag>Tag	p.Q129*	AC104534.3_ENST00000594769.1_Silent_p.C298C	NM_001398.2	NP_001389.2			enoyl CoA hydratase 1, peroxisomal											cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)	6	all_cancers(60;9.36e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			CCTTTGGGCTGCAGGATGTCC	0.562000													13	8					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	80271462	80271462	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:80271462C>T	ENST00000281127.7	+	5	1796	c.917C>T	c.(916-918)tCa>tTa	p.S306L	NRXN3_ENST00000557594.1_Missense_Mutation_p.S306L|NRXN3_ENST00000428277.2_Missense_Mutation_p.S336L|NRXN3_ENST00000335750.5_Missense_Mutation_p.S938L|NRXN3_ENST00000554719.1_Missense_Mutation_p.S938L|NRXN3_ENST00000556003.1_Intron	NM_138970.3	NP_620426.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	306					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		CAGCCAACATCAGATGATCTT	0.388000													19	65					0	0	1	0	0
GAP43	2596	broad.mit.edu	37	3	115395199	115395199	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:115395199G>A	ENST00000393780.3	+	3	946	c.478G>A	c.(478-480)Gcc>Acc	p.A160T	GAP43_ENST00000305124.6_Missense_Mutation_p.A124T	NM_001130064.1	NP_001123536.1	P17677	NEUM_HUMAN	growth associated protein 43	124					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	32				GBM - Glioblastoma multiforme(114;0.164)		AGAGCAGGCAGCCCCCCAGGC	0.607000													18	11					0	0	1	0	0
FMO1	2326	broad.mit.edu	37	1	171249965	171249965	+	Missense_Mutation	SNP	G	G	A	rs16864310		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:171249965G>A	ENST00000354841.4	+	5	799	c.668G>A	c.(667-669)cGa>cAa	p.R223Q	FMO1_ENST00000402921.2_Missense_Mutation_p.R160Q|FMO1_ENST00000367750.3_Missense_Mutation_p.R223Q|FMO1_ENST00000469112.1_3'UTR			Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	223			R -> Q (in dbSNP:rs16864310).		NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(2)|skin(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GTGATCAGCCGAATCTTTGAC	0.517000													7	65					0	0	1	0	0
HK2	3099	broad.mit.edu	37	2	75100492	75100492	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:75100492G>A	ENST00000290573.2	+	5	1185	c.585G>A	c.(583-585)agG>agA	p.R195R	HK2_ENST00000409174.1_Silent_p.R167R	NM_000189.4	NP_000180.2	P52789	HXK2_HUMAN	hexokinase 2	195	Regulatory.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	43						CCATCCAGAGGAGAGGGGTGA	0.557000													7	55					0	0	1	0	0
BEST2	54831	broad.mit.edu	37	19	12868835	12868835	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:12868835C>T	ENST00000549706.1	+	10	1798	c.1474C>T	c.(1474-1476)Ccg>Tcg	p.P492S	BEST2_ENST00000553030.1_Missense_Mutation_p.P492S|BEST2_ENST00000042931.1_Missense_Mutation_p.P492S			Q8NFU1	BEST2_HUMAN	bestrophin 2	492					membrane depolarization|sensory perception of smell	chloride channel complex|cilium|plasma membrane	chloride channel activity			breast(3)|endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)	12						GCCCCGGGGTCCGGCGCCACC	0.697000													15	16					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15752390	15752390	+	Silent	SNP	G	G	A	rs150573744	byFrequency	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:15752390G>A	ENST00000221307.7	+	2	213	c.165G>A	c.(163-165)ccG>ccA	p.P55P	CYP4F3_ENST00000586182.1_Silent_p.P55P|CYP4F3_ENST00000591058.1_Silent_p.P55P|CYP4F3_ENST00000585846.1_Silent_p.P55P	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	55					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						CGCAACCCCCGAAACGGAATT	0.617000													61	32					0	0	1	0	0
ALDOC	230	broad.mit.edu	37	17	26900845	26900845	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:26900845C>T	ENST00000226253.4	-	8	1382	c.907G>A	c.(907-909)Ggg>Agg	p.G303R	ALDOC_ENST00000395321.2_Missense_Mutation_p.G303R|RP11-192H23.5_ENST00000585189.1_RNA|ALDOC_ENST00000395319.3_Missense_Mutation_p.G275R	NM_005165.2	NP_005156.1	P09972	ALDOC_HUMAN	aldolase C, fructose-bisphosphate	303					fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis	cytosol	cytoskeletal protein binding|fructose-bisphosphate aldolase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	11	Lung NSC(42;0.00431)					AGGGCACGCCCATAGGAGAAG	0.612000													79	19					0	0	1	0	0
KLK7	5650	broad.mit.edu	37	19	51483547	51483547	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:51483547G>A	ENST00000391807.1	-	4	519	c.418C>T	c.(418-420)Cct>Tct	p.P140S	KLK7_ENST00000336317.4_Missense_Mutation_p.P27S|KLK7_ENST00000597707.1_Missense_Mutation_p.P68S|CTB-147C22.9_ENST00000594512.1_RNA|KLK7_ENST00000595820.1_Missense_Mutation_p.P140S	NM_139277.2	NP_644806.1	P49862	KLK7_HUMAN	kallikrein-related peptidase 7	140	Peptidase S1.				epidermis development|proteolysis	extracellular region	serine-type endopeptidase activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(2)	19		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00382)|GBM - Glioblastoma multiforme(134;0.00895)		GTGGTTCCAGGGGGTTCGCAG	0.612000													21	24					0	0	1	0	0
NEURL2	140825	broad.mit.edu	37	20	44519263	44519263	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:44519263G>A	ENST00000372518.4	-	1	663	c.368C>T	c.(367-369)cCc>cTc	p.P123L		NM_001278535.1|NM_080749.2	NP_001265464.1|NP_542787.1	Q9BR09	NEUL2_HUMAN	neuralized E3 ubiquitin protein ligase 2	123	NHR.				intracellular signal transduction					large_intestine(1)|lung(2)	3		Myeloproliferative disorder(115;0.0122)				GCCCTCCCGGGGCACGCGGTT	0.687000													13	53					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11023012	11023012	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:11023012C>T	ENST00000304623.8	-	17	3057	c.2868G>A	c.(2866-2868)tcG>tcA	p.S956S	CTNND2_ENST00000458100.2_Silent_p.S523S|CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000359640.2_Silent_p.S898S|CTNND2_ENST00000503622.1_Silent_p.S619S|CTNND2_ENST00000511377.1_Silent_p.S865S	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	956					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding	p.S956S(1)		NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						CTGTGTCATCCGACATGGCCT	0.517000													57	11					0	0	1	0	0
BCS1L	617	broad.mit.edu	37	2	219525985	219525985	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:219525985C>T	ENST00000431802.1	+	2	974	c.275C>T	c.(274-276)tCc>tTc	p.S92F	BCS1L_ENST00000392110.2_Missense_Mutation_p.S92F|BCS1L_ENST00000412366.1_Missense_Mutation_p.S92F|BCS1L_ENST00000392109.1_Missense_Mutation_p.S92F|BCS1L_ENST00000392111.2_Missense_Mutation_p.S92F|BCS1L_ENST00000359273.3_Missense_Mutation_p.S92F|BCS1L_ENST00000439945.1_Missense_Mutation_p.S92F			Q9Y276	BCS1_HUMAN	BC1 (ubiquinol-cytochrome c reductase) synthesis-like	92					mitochondrial respiratory chain complex I assembly|mitochondrial respiratory chain complex III assembly|mitochondrial respiratory chain complex IV assembly	integral to membrane|mitochondrial respiratory chain complex III	ATP binding|nucleoside-triphosphatase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)	8		Renal(207;0.0474)		Epithelial(149;7.12e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGCCGCATTTCCACTAAGTTT	0.527000													31	120					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188692	140188692	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:140188692G>A	ENST00000530339.1	+	1	1920	c.1920G>A	c.(1918-1920)acG>acA	p.T640T	PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Silent_p.T640T|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000356878.4_Silent_p.T640T|PCDHA1_ENST00000394633.3_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGACGAAACGGACGCTCCGC	0.672000													64	22					0	0	1	0	0
FAM189A2	9413	broad.mit.edu	37	9	72006631	72006631	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:72006631G>A	ENST00000257515.8	+	11	1684	c.1264G>A	c.(1264-1266)Ggg>Agg	p.G422R	FAM189A2_ENST00000303068.7_Missense_Mutation_p.G257R|FAM189A2_ENST00000455972.1_Missense_Mutation_p.G422R|FAM189A2_ENST00000377216.3_Missense_Mutation_p.G209R	NM_004816.3	NP_004807.3	Q15884	F1892_HUMAN	family with sequence similarity 189, member A2	422						integral to membrane				endometrium(3)|large_intestine(5)|liver(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	12						CACACCAGCGGGGAGGCCCCG	0.677000													33	13					0	0	1	0	0
BMP2	650	broad.mit.edu	37	20	6759178	6759178	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:6759178C>T	ENST00000378827.4	+	3	1852	c.633C>T	c.(631-633)ccC>ccT	p.P211P		NM_001200.2	NP_001191.1	P12643	BMP2_HUMAN	bone morphogenetic protein 2	211					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	13					Simvastatin(DB00641)	ATGTCACCCCCGCTGTGATGC	0.527000													33	16					0	0	1	0	0
OR52N2	390077	broad.mit.edu	37	11	5842147	5842147	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:5842147C>T	ENST00000317037.2	+	1	604	c.582C>T	c.(580-582)ttC>ttT	p.F194F	TRIM5_ENST00000380027.1_Intron	NM_001005174.1	NP_001005174.1	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N, member 2	194					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|urinary_tract(1)	32		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTGGCAATTTCAAGGTCAATG	0.473000													102	65					0	0	1	0	0
XKR7	343702	broad.mit.edu	37	20	30584504	30584504	+	Silent	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:30584504T>C	ENST00000217299.3	+	3	1158	c.984T>C	c.(982-984)ttT>ttC	p.F328F		NM_001011718.1	NP_001011718.1	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related family, member 7	328						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			AGCTCTATTTTGGCATCTTCA	0.592000													23	56					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52321411	52321411	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:52321411G>A	ENST00000356297.4	-	17	2873	c.2773C>T	c.(2773-2775)Cct>Tct	p.P925S	PXDNL_ENST00000543296.1_Missense_Mutation_p.P925S	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	925					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GGAGGCCAAGGAAAGCCTGTC	0.627000													10	22					0	0	1	0	0
PMEPA1	56937	broad.mit.edu	37	20	56228099	56228099	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:56228099C>T	ENST00000341744.3	-	3	627	c.308G>A	c.(307-309)gGa>gAa	p.G103E	PMEPA1_ENST00000347215.4_Missense_Mutation_p.G68E|PMEPA1_ENST00000395816.3_Missense_Mutation_p.G53E|PMEPA1_ENST00000395814.1_Missense_Mutation_p.G53E|PMEPA1_ENST00000265626.4_Missense_Mutation_p.G53E	NM_020182.4	NP_064567.2	Q969W9	PMEPA_HUMAN	prostate transmembrane protein, androgen induced 1	103					androgen receptor signaling pathway	integral to membrane|plasma membrane	WW domain binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)	16						CTCTGGGATTCCGTTGCCTGA	0.632000													4	8					0	0	1	0	0
OR10R2	343406	broad.mit.edu	37	1	158450225	158450225	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:158450225C>T	ENST00000368152.1	+	1	558	c.558C>T	c.(556-558)ctC>ctT	p.L186L	RP11-144L1.4_ENST00000419738.1_RNA|RP11-144L1.4_ENST00000426251.1_RNA	NM_001004472.1	NP_001004472.1	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R, member 2	186					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(26)|pancreas(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	41	all_hematologic(112;0.0378)					TTTTCAGCCTCCCTTTTTGTA	0.438000													51	135					0	0	1	0	0
OR4C16	219428	broad.mit.edu	37	11	55339780	55339780	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:55339780C>T	ENST00000314634.3	+	1	177	c.177C>T	c.(175-177)ttC>ttT	p.F59F		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	59					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				CAATGTTCTTCTTCCTTTTCT	0.388000													46	49					0	0	1	0	0
METAP1D	254042	broad.mit.edu	37	2	172944869	172944869	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:172944869G>A	ENST00000315796.4	+	9	1251	c.864G>A	c.(862-864)acG>acA	p.T288T	METAP1D_ENST00000488581.1_3'UTR	NM_199227.1	NP_954697.1	Q6UB28	AMP1D_HUMAN	methionyl aminopeptidase type 1D (mitochondrial)	288					N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis	mitochondrion	aminopeptidase activity|metal ion binding|metalloexopeptidase activity			NS(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)	8						CAATCATCACGGAGGGATCCC	0.393000													53	22					0	0	1	0	0
FCHO1	23149	broad.mit.edu	37	19	17892535	17892535	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:17892535C>T	ENST00000594202.1	+	23	2122	c.1843C>T	c.(1843-1845)Ccg>Tcg	p.P615S	FCHO1_ENST00000595033.1_Missense_Mutation_p.P565S|FCHO1_ENST00000252771.7_Missense_Mutation_p.P615S|FCHO1_ENST00000597512.1_Missense_Mutation_p.P622S|FCHO1_ENST00000389133.4_Missense_Mutation_p.P615S|FCHO1_ENST00000596536.1_Missense_Mutation_p.P615S|FCHO1_ENST00000539407.1_Missense_Mutation_p.P615S|FCHO1_ENST00000596951.1_Missense_Mutation_p.P615S|FCHO1_ENST00000600676.1_Missense_Mutation_p.P615S	NM_001161357.1	NP_001154829.1	O14526	FCHO1_HUMAN	FCH domain only 1	615										NS(2)|breast(1)|large_intestine(6)|liver(1)|lung(12)	22						CTCCCGGGGTCCGAGCCCTGT	0.632000													52	57					0	0	1	0	0
MAN1C1	57134	broad.mit.edu	37	1	26013026	26013026	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:26013026C>T	ENST00000374332.4	+	2	966	c.637_splice	c.e2+1	p.F212_splice	MAN1C1_ENST00000263979.3_Splice_Site_p.F32_splice|MAN1C1_ENST00000473891.1_3'UTR	NM_020379.2	NP_065112.1	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	212					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(7)|pancreas(1)|prostate(1)|skin(2)	25		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		GTAACATGTTCGGTGAGTCGA	0.498000													76	26					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109577350	109577350	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:109577350C>T	ENST00000338432.7	+	2	259	c.140C>T	c.(139-141)cCc>cTc	p.P47L	ACACB_ENST00000377854.5_Missense_Mutation_p.P47L|ACACB_ENST00000377848.3_Missense_Mutation_p.P47L			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	47					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	AGCCAGGAGCCCTTTCCAGCC	0.552000													21	49					0	0	1	0	0
SREBF2	6721	broad.mit.edu	37	22	42274097	42274097	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:42274097C>T	ENST00000361204.4	+	9	1897	c.1731C>T	c.(1729-1731)caC>caT	p.H577H		NM_004599.2	NP_004590.2	Q12772	SRBP2_HUMAN	sterol regulatory element binding transcription factor 2	577					cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			NS(2)|breast(6)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						TCTGGAGGCACCGGAAACAGG	0.552000													35	49					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37442557	37442557	+	Nonsense_Mutation	SNP	A	A	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:37442557A>T	ENST00000374660.1	+	13	1696	c.1597A>T	c.(1597-1599)Aaa>Taa	p.K533*	ANKRD30A_ENST00000602533.1_Nonsense_Mutation_p.K533*|ANKRD30A_ENST00000361713.1_Nonsense_Mutation_p.K533*			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	589						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						TACACATCAAAAAGAAATAGA	0.308000													39	52					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117665378	117665378	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:117665378G>A	ENST00000317775.6	-	23	4159	c.3474C>T	c.(3472-3474)ttC>ttT	p.F1158F	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Silent_p.F1192F	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	1158	FAD-binding FR-type.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	GGATAGATGGGAACTCCTCCA	0.582000													21	56					0	0	1	0	0
ZHX3	23051	broad.mit.edu	37	20	39833197	39833197	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:39833197G>A	ENST00000309060.3	-	4	775	c.360C>T	c.(358-360)acC>acT	p.T120T	ZHX3_ENST00000557816.1_Silent_p.T120T|ZHX3_ENST00000540170.1_Silent_p.T120T|ZHX3_ENST00000559234.1_Silent_p.T120T|ZHX3_ENST00000432768.2_Silent_p.T120T|ZHX3_ENST00000560361.1_Silent_p.T120T|ZHX3_ENST00000558993.1_Silent_p.T120T|ZHX3_ENST00000544979.2_Silent_p.T120T			Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	120					negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(5)|large_intestine(8)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		Myeloproliferative disorder(115;0.00425)				GCCCCTCAGGGGTTTTTGCCA	0.493000													47	100					0	0	1	0	0
FAM71E1	112703	broad.mit.edu	37	19	50979490	50979490	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:50979490G>A	ENST00000600100.1	-	1	520	c.156C>T	c.(154-156)ctC>ctT	p.L52L	FAM71E1_ENST00000595790.1_Silent_p.L52L			Q6IPT2	F71E1_HUMAN	family with sequence similarity 71, member E1	52										breast(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.0077)|GBM - Glioblastoma multiforme(134;0.026)		GCGGACGGAGGAGCAGAGGGA	0.652000													13	45					0	0	1	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37734744	37734744	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:37734744G>A	ENST00000330843.4	-	2	709	c.697C>T	c.(697-699)Cag>Tag	p.Q233*	RAB11FIP1_ENST00000524118.1_Nonsense_Mutation_p.Q85*|RAB11FIP1_ENST00000522727.1_Nonsense_Mutation_p.Q85*|RAB11FIP1_ENST00000287263.4_Nonsense_Mutation_p.Q233*	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	233					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			GACATGGACTGGGAAAGAGGC	0.458000													54	81					0	0	1	0	0
LEPREL1	55214	broad.mit.edu	37	3	189691793	189691793	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:189691793C>T	ENST00000319332.5	-	10	1650	c.1452_splice	c.e10-1	p.G485_splice	LEPREL1_ENST00000427335.2_Splice_Site_p.G304_splice	NM_018192.3	NP_060662.2	Q8IVL5	P3H2_HUMAN	leprecan-like 1	485					collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(5)	41	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	AGCATGATTCCCTGGAAGCAA	0.403000													40	28					0	0	1	0	0
NFE2	4778	broad.mit.edu	37	12	54686207	54686207	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:54686207C>T	ENST00000540264.2	-	2	1582	c.1073G>A	c.(1072-1074)gGg>gAg	p.G358E	RP11-968A15.8_ENST00000553061.1_RNA|NFE2_ENST00000435572.2_Missense_Mutation_p.G358E|NFE2_ENST00000553070.1_Missense_Mutation_p.G358E|NFE2_ENST00000312156.4_Missense_Mutation_p.G358E			Q16621	NFE2_HUMAN	nuclear factor, erythroid 2	358					blood circulation|blood coagulation|multicellular organismal development|nucleosome disassembly|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	actin cytoskeleton|cytoplasm|PML body	protein dimerization activity|protein N-terminus binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|WW domain binding			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(7)|upper_aerodigestive_tract(2)	16						GAAGATGGTCCCATCGGCAGC	0.572000													25	26					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141578867	141578867	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:141578867G>A	ENST00000442267.2	-	12	2095	c.2021C>T	c.(2020-2022)tCc>tTc	p.S674F		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	674	Rab-GAP TBC.					intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				CCAAGACAGGGAGATGGTGGA	0.483000													50	40					0	0	1	0	0
WBP4	11193	broad.mit.edu	37	13	41650276	41650276	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:41650276C>T	ENST00000379487.3	+	8	1059	c.659C>T	c.(658-660)tCc>tTc	p.S220F	WBP4_ENST00000542082.1_Missense_Mutation_p.S199F	NM_007187.3	NP_009118.1	O75554	WBP4_HUMAN	WW domain binding protein 4	220					nuclear mRNA cis splicing, via spliceosome	nuclear speck|spliceosomal complex	nucleic acid binding|proline-rich region binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(2)|prostate(1)|skin(1)	12		Lung NSC(96;3.55e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;3.11e-09)|Epithelial(112;3.37e-06)|OV - Ovarian serous cystadenocarcinoma(117;8.3e-05)|GBM - Glioblastoma multiforme(144;0.00102)|BRCA - Breast invasive adenocarcinoma(63;0.07)		CTAGATGAATCCAAATCATCA	0.418000													14	22					0	0	1	0	0
BCAS4	55653	broad.mit.edu	37	20	49434750	49434750	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:49434750G>A	ENST00000358791.5	+	2	283	c.183G>A	c.(181-183)gcG>gcA	p.A61A	BCAS4_ENST00000371608.2_Silent_p.A61A|BCAS4_ENST00000262591.5_Silent_p.A61A|BCAS4_ENST00000485049.1_3'UTR	NM_017843.3	NP_060313.3	Q8TDM0	BCAS4_HUMAN	breast carcinoma amplified sequence 4	61		Breakpoint for translocation to form BCAS4-BCAS3.				cytoplasm				large_intestine(2)|lung(2)|pancreas(1)|upper_aerodigestive_tract(1)	6						TTTTTCAGGCGAAGGAGGTGG	0.488000											OREG0026033	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	12					0	0	1	0	0
CDC7	8317	broad.mit.edu	37	1	91977196	91977196	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:91977196G>A	ENST00000428239.1	+	5	637	c.378G>A	c.(376-378)aaG>aaA	p.K126K	CDC7_ENST00000430031.2_Silent_p.K98K|CDC7_ENST00000234626.6_Silent_p.K126K	NM_001134420.1	NP_001127892.1	O00311	CDC7_HUMAN	cell division cycle 7	126	Protein kinase.				cell cycle checkpoint|cell division|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|positive regulation of cell proliferation|regulation of S phase	cytoplasm|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|stomach(2)	23		all_lung(203;0.0165)|Lung NSC(277;0.0562)		all cancers(265;0.00108)|Epithelial(280;0.0184)|KIRC - Kidney renal clear cell carcinoma(1967;0.124)		GCTTTAGGAAGAATGATCATG	0.338000													94	36					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56382202	56382202	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:56382202C>T	ENST00000301295.6	+	7	2786	c.2364C>T	c.(2362-2364)ttC>ttT	p.F788F	NLRP4_ENST00000587891.1_Silent_p.F713F|NLRP4_ENST00000346986.5_Silent_p.F732F	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	788							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GGTTGGCTTTCTGCCACCTCA	0.483000													19	25					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11097537	11097537	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr21:11097537G>A	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		caacaagaacgaaactcACAG	0.557000													8	30					0	0	1	0	0
ITPA	3704	broad.mit.edu	37	20	3202489	3202489	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:3202489C>T	ENST00000380113.3	+	7	606	c.414C>T	c.(412-414)ggC>ggT	p.G138G	ITPA_ENST00000455664.1_Silent_p.G121G|ITPA_ENST00000483354.1_3'UTR|ITPA_ENST00000399838.3_Silent_p.G97G	NM_033453.3	NP_258412.1	Q9BY32	ITPA_HUMAN	inosine triphosphatase (nucleoside triphosphate pyrophosphatase)	138					nucleotide metabolic process	cytoplasm	metal ion binding|nucleoside-triphosphate diphosphatase activity|nucleotide binding			autonomic_ganglia(1)|large_intestine(3)|ovary(1)|stomach(1)	6						TGTGGCAGGGCCGGATCGTGG	0.577000													29	31					0	0	1	0	0
LGR5	8549	broad.mit.edu	37	12	71977544	71977544	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:71977544C>T	ENST00000266674.5	+	18	2065	c.1754C>T	c.(1753-1755)tCc>tTc	p.S585F	LGR5_ENST00000536515.1_Missense_Mutation_p.S513F|RP11-186F10.2_ENST00000546601.1_RNA|LGR5_ENST00000540815.2_Missense_Mutation_p.S561F			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	585						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						GTTTTCAGATCCCCTCTGTAC	0.502000													28	57					0	0	1	0	0
SEL1L3	23231	broad.mit.edu	37	4	25760646	25760646	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:25760646G>A	ENST00000399878.3	-	21	3122	c.3000C>T	c.(2998-3000)atC>atT	p.I1000I	SEL1L3_ENST00000264868.5_Silent_p.I965I|SEL1L3_ENST00000502949.1_Silent_p.I847I	NM_015187.3	NP_056002.2	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3 (C. elegans)	1000						integral to membrane	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(2)	14						TATGGTGTGGGATTATCGTAC	0.408000													32	22					0	0	1	0	0
UNC5CL	222643	broad.mit.edu	37	6	41002663	41002663	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:41002663C>T	ENST00000244565.3	-	2	239	c.151G>A	c.(151-153)Gaa>Aaa	p.E51K	UNC5CL_ENST00000373164.1_Missense_Mutation_p.E51K	NM_173561.2	NP_775832.2	Q8IV45	UN5CL_HUMAN	unc-5 homolog C (C. elegans)-like	51					signal transduction	cytoplasm|integral to membrane				endometrium(1)|kidney(3)|large_intestine(3)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	13	Ovarian(28;0.0418)|Colorectal(47;0.196)					GACACTGGTTCCTCTTGACCA	0.592000													13	72					0	0	1	0	0
SETD1A	9739	broad.mit.edu	37	16	30978285	30978285	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:30978285C>T	ENST00000262519.8	+	9	3272	c.2586C>T	c.(2584-2586)tcC>tcT	p.S862S		NM_014712.1	NP_055527.1	O15047	SET1A_HUMAN	SET domain containing 1A	862					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(21)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	59						GCCTGCTGTCCCTCGTGGACT	0.627000													4	6					0	0	1	0	0
RGL1	23179	broad.mit.edu	37	1	183857636	183857636	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:183857636C>T	ENST00000304685.3	+	9	1546	c.1085C>T	c.(1084-1086)tCc>tTc	p.S362F	RGL1_ENST00000367531.1_Missense_Mutation_p.S362F|RGL1_ENST00000536277.1_Missense_Mutation_p.S325F|RGL1_ENST00000360851.3_Missense_Mutation_p.S327F|RGL1_ENST00000539189.1_Missense_Mutation_p.S327F	NM_015149.3	NP_055964.3	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation stimulator-like 1	327	Ras-GEF.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(17)|ovary(4)|prostate(3)|stomach(1)	51						AATTTTTCCTCCTTGAGGGCC	0.428000													26	172					0	0	1	0	0
SLC4A7	9497	broad.mit.edu	37	3	27444630	27444630	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:27444630G>A	ENST00000295736.5	-	15	2364	c.2294_splice	c.e15+1	p.S765_splice	SLC4A7_ENST00000425128.2_3'UTR|SLC4A7_ENST00000455077.1_Splice_Site_p.S646_splice|SLC4A7_ENST00000454389.1_Splice_Site_p.S774_splice|SLC4A7_ENST00000446700.1_Splice_Site_p.S757_splice|SLC4A7_ENST00000440156.1_Splice_Site_p.S761_splice|SLC4A7_ENST00000388777.4_Splice_Site_p.S315_splice|SLC4A7_ENST00000428386.1_Splice_Site_p.S641_splice|SLC4A7_ENST00000437179.1_Splice_Site_p.S646_splice|SLC4A7_ENST00000445684.1_Splice_Site_p.S761_splice|SLC4A7_ENST00000435667.2_Splice_Site_p.S650_splice	NM_003615.4	NP_003606.3	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 7	765						apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(9)|ovary(4)|skin(1)	38						AAATACTTACGAGTAGCTGGT	0.338000													14	36					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183675553	183675553	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:183675553C>T	ENST00000511685.1	+	22	4156	c.4033C>T	c.(4033-4035)Ccc>Tcc	p.P1345S	TENM3_ENST00000406950.2_Missense_Mutation_p.P1345S|TENM3_ENST00000502950.1_3'UTR					teneurin transmembrane protein 3																		TCTGGAATGGCCCACTGACCT	0.393000													4	5					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241715317	241715317	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:241715317G>A	ENST00000498729.2	-	11	1155	c.909C>T	c.(907-909)ttC>ttT	p.F303F	KIF1A_ENST00000320389.7_Silent_p.F303F	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	303	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		GGTACGGAATGAAATCTGTCT	0.577000													8	45					0	0	1	0	0
IQSEC2	23096	broad.mit.edu	37	X	53285072	53285072	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:53285072G>A	ENST00000396435.3	-	3	1109	c.909C>T	c.(907-909)gtC>gtT	p.V303V	IQSEC2_ENST00000375365.2_Silent_p.V98V|IQSEC2_ENST00000375368.5_Silent_p.V293V	NM_001111125.2	NP_001104595.1	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2	293					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(10)|ovary(4)|skin(1)	29						TCCTCAGGGCGACACTGGCTG	0.652000													14	1					0	0	1	0	0
OR8S1	341568	broad.mit.edu	37	12	48920005	48920005	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:48920005C>T	ENST00000310194.1	+	1	591	c.591C>T	c.(589-591)atC>atT	p.I197I	OR8S1_ENST00000551654.1_Intron	NM_001005203.2	NP_001005203.2	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S, member 1	197					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|skin(4)	22						GAAGCCTCATCGCCTTGCTCT	0.473000													17	31					0	0	1	0	0
LEPR	3953	broad.mit.edu	37	1	66085674	66085674	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:66085674G>A	ENST00000349533.6	+	17	2644	c.2459G>A	c.(2458-2460)gGa>gAa	p.G820E	LEPR_ENST00000371058.1_Missense_Mutation_p.G820E|LEPR_ENST00000406510.3_Intron|LEPR_ENST00000371059.3_Missense_Mutation_p.G820E|LEPR_ENST00000371060.3_Missense_Mutation_p.G820E|LEPR_ENST00000344610.8_Missense_Mutation_p.G820E	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	820	Fibronectin type-III 4.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		GAAGGAGTGGGAAAACCAAAG	0.318000													32	8					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3238336	3238336	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:3238336C>T	ENST00000217939.6	-	5	5544	c.5390G>A	c.(5389-5391)gGa>gAa	p.G1797E		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1797						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TGAGGGTGATCCCGTGGTCTG	0.498000													22	1					0	0	1	0	0
ANKRD10	55608	broad.mit.edu	37	13	111532020	111532020	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:111532020G>A	ENST00000267339.2	-	6	1361	c.1227C>T	c.(1225-1227)gcC>gcT	p.A409A	ANKRD10_ENST00000375758.5_3'UTR	NM_017664.2	NP_060134.2	Q9NXR5	ANR10_HUMAN	ankyrin repeat domain 10	409										central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(3)	9	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		all cancers(43;0.0882)|BRCA - Breast invasive adenocarcinoma(86;0.188)|Lung(89;0.208)			TGCCCAGCACGGCACTGTCGT	0.587000													10	17					0	0	1	0	0
IPPK	64768	broad.mit.edu	37	9	95396730	95396730	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:95396730A>G	ENST00000287996.3	-	11	1384	c.1108T>C	c.(1108-1110)Tac>Cac	p.Y370H	IPPK_ENST00000375522.1_Missense_Mutation_p.Y42H	NM_022755.5	NP_073592.1	Q9H8X2	IPPK_HUMAN	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	370					inositol or phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol pentakisphosphate 2-kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(2)|urinary_tract(1)	15						AGCTTCTGGTAAAATGCTTCA	0.453000											OREG0019315	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	39					0	0	1	0	0
EBF2	64641	broad.mit.edu	37	8	25718576	25718576	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:25718576C>T	ENST00000520164.1	-	13	1868	c.1331G>A	c.(1330-1332)gGa>gAa	p.G444E	EBF2_ENST00000408929.3_Missense_Mutation_p.G296E|EBF2_ENST00000535548.1_Missense_Mutation_p.G175E	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	444					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding	p.G444E(1)		endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		TTGATTATTTCCTTGTGTTGA	0.473000													39	54					0	0	1	0	0
CEP97	79598	broad.mit.edu	37	3	101476691	101476691	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:101476691C>T	ENST00000341893.3	+	9	1993	c.1241C>T	c.(1240-1242)cCa>cTa	p.P414L	CEP97_ENST00000327230.4_Missense_Mutation_p.P414L|CEP97_ENST00000494050.1_Missense_Mutation_p.P355L			Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	414	CEP110 binding.					centrosome|nucleus	protein binding			cervix(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	29						GGACTGTCTCCACTATCACCT	0.478000													18	18					0	0	1	0	0
PRRC2A	7916	broad.mit.edu	37	6	31599164	31599164	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:31599164G>A	ENST00000376033.2	+	16	2948	c.2714G>A	c.(2713-2715)gGa>gAa	p.G905E	PRRC2A_ENST00000376007.4_Missense_Mutation_p.G905E	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	905	4 X 57 AA type A repeats.			PARGVGSGGQ -> LPASRSGA (in Ref. 1; AAA35585/AAA35586 and 8; CAA78744).		cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						CCTGCCCGCGGAGTCGGGAGT	0.657000													11	23					0	0	1	0	0
CFAP221	200373	broad.mit.edu	37	2	120373196	120373196	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:120373196G>A	ENST00000602047.1	+	15	1575	c.463G>A	c.(463-465)Gaa>Aaa	p.E155K	PCDP1_ENST00000413369.3_Missense_Mutation_p.E441K|PCDP1_ENST00000597189.1_3'UTR			Q4G0U5	PCDP1_HUMAN		441						cilium	calmodulin binding					Colorectal(110;0.196)					GAAAATCAAGGAATTTCATCC	0.343000													9	6					0	0	1	0	0
ANKRD33	341405	broad.mit.edu	37	12	52282528	52282528	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:52282528C>T	ENST00000301190.6	+	2	549	c.322C>T	c.(322-324)Ccc>Tcc	p.P108S	ANKRD33_ENST00000547119.1_3'UTR|ANKRD33_ENST00000340970.4_5'UTR|ANKRD33_ENST00000538991.1_5'UTR	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33	0										endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		CCACAATGATCCCACCCAGCT	0.642000													23	46					0	0	1	0	0
NELFA	7469	broad.mit.edu	37	4	1985645	1985645	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:1985645G>A	ENST00000382882.3	-	9	2382	c.1265C>T	c.(1264-1266)cCg>cTg	p.P422L	NELFA_ENST00000411638.1_Missense_Mutation_p.P411L|NELFA_ENST00000542778.1_Missense_Mutation_p.P276L	NM_005663.4	NP_005654.3			negative elongation factor complex member A																		CATGGCAACCGGGGGTGTCTG	0.682000													24	23					0	0	1	0	0
OSBPL2	9885	broad.mit.edu	37	20	60861677	60861677	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:60861677C>T	ENST00000313733.3	+	11	1237	c.1035C>T	c.(1033-1035)gaC>gaT	p.D345D	OSBPL2_ENST00000439951.2_Silent_p.D253D|OSBPL2_ENST00000358053.2_Silent_p.D333D	NM_144498.1	NP_653081.1	Q9H1P3	OSBL2_HUMAN	oxysterol binding protein-like 2	345					lipid transport		lipid binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;1.33e-06)			ACGTGGCTGACGACGTGCCTG	0.647000													59	127					0	0	1	0	0
CALCB	797	broad.mit.edu	37	11	15098931	15098931	+	Silent	SNP	C	C	T	rs145827382	byFrequency	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:15098931C>T	ENST00000523376.1	+	9	1619	c.357C>T	c.(355-357)ttC>ttT	p.F119F	CALCB_ENST00000533448.1_Silent_p.F108F|CALCB_ENST00000324229.6_Silent_p.F108F			P10092	CALCB_HUMAN	calcitonin-related polypeptide beta	108					cellular calcium ion homeostasis|signal transduction|vasodilation	extracellular region|soluble fraction	neuropeptide hormone activity	p.F108F(1)		endometrium(1)|large_intestine(1)|lung(1)|skin(2)	5						AGAGCAACTTCGTGCCCACCA	0.577000													10	23					0	0	1	0	0
SERPINA10	51156	broad.mit.edu	37	14	94752523	94752523	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:94752523C>T	ENST00000554723.1	-	4	1603	c.1185G>A	c.(1183-1185)atG>atA	p.M395I	SERPINA10_ENST00000554173.1_Missense_Mutation_p.M355I|SERPINA10_ENST00000393096.1_Missense_Mutation_p.M355I|SERPINA10_ENST00000261994.4_Missense_Mutation_p.M355I			Q9UK55	ZPI_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	355					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	33		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		TTCTGATTCCCATCTGCCTAA	0.428000													16	41					0	0	1	0	0
PHF14	9678	broad.mit.edu	37	7	11022696	11022696	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:11022696G>A	ENST00000403050.3	+	3	1262	c.810G>A	c.(808-810)aaG>aaA	p.K270K	PHF14_ENST00000445996.2_Intron	NM_014660.3	NP_055475.2	O94880	PHF14_HUMAN	PHD finger protein 14	270							zinc ion binding			NS(2)|breast(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	35				UCEC - Uterine corpus endometrioid carcinoma (126;0.205)		GTTGCAAGAAGAAGAAGAGTA	0.448000													6	13					0	0	1	0	0
MBL2	4153	broad.mit.edu	37	10	54530431	54530431	+	Splice_Site	SNP	C	C	T	rs55902142		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:54530431C>T	ENST00000373968.3	-	2	367	c.304_splice	c.e2+1	p.P101_splice	MBL2_ENST00000493043.1_5'UTR	NM_000242.2	NP_000233.1	P11226	MBL2_HUMAN	mannose-binding lectin (protein C) 2, soluble	101					acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			breast(1)|endometrium(2)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21						GGTCCTTACCCGGACTTTTTC	0.562000													59	17					0	0	1	0	0
OR2A2	442361	broad.mit.edu	37	7	143806719	143806719	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:143806719G>A	ENST00000408979.2	+	1	113	c.44G>A	c.(43-45)gGa>gAa	p.G15E		NM_001005480.2	NP_001005480.2	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A, member 2	15					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)|skin(4)	22	Melanoma(164;0.0783)					ACCCTGCTGGGATTCCAGGTT	0.522000													27	32					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955471	18955471	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:18955471C>T	ENST00000302797.3	-	1	1085	c.861G>A	c.(859-861)ctG>ctA	p.L287L		NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	287					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						GAACCAGCTTCAGGTTCTGCC	0.527000													9	96					0	0	1	0	0
LGR5	8549	broad.mit.edu	37	12	71946958	71946958	+	Silent	SNP	C	C	T	rs149369154	byFrequency	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:71946958C>T	ENST00000266674.5	+	5	845	c.534C>T	c.(532-534)ccC>ccT	p.P178P	LGR5_ENST00000540815.2_Silent_p.P178P|LGR5_ENST00000536515.1_Intron			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	178						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						CAGAAATCCCCGTCCAGGCTT	0.502000													15	52					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30336640	30336640	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:30336640C>T	ENST00000375377.1	-	2	203	c.102G>A	c.(100-102)agG>agA	p.R34R		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	34										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						GTGTCCCAGTCCTCGCTGCCT	0.612000													51	12					0	0	1	0	0
PFKP	5214	broad.mit.edu	37	10	3162143	3162143	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:3162143C>T	ENST00000381075.2	+	18	1790	c.1566C>T	c.(1564-1566)gtC>gtT	p.V522V	PFKP_ENST00000381125.4_Silent_p.V530V	NM_001242339.1	NP_001229268.1	Q01813	K6PP_HUMAN	phosphofructokinase, platelet	530					glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)		AGTTCTGTGTCCCCATGGTCA	0.602000											OREG0019976	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	48	10					0	0	1	0	0
MARK1	4139	broad.mit.edu	37	1	220777414	220777414	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:220777414G>A	ENST00000402574.1	+	6	1027	c.25G>A	c.(25-27)Gta>Ata	p.V9I	MARK1_ENST00000366917.4_Missense_Mutation_p.V144I|MARK1_ENST00000366918.4_Missense_Mutation_p.V122I	NM_018650.3	NP_061120.3	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	144					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(12)|lung(22)|ovary(4)|pancreas(1)|skin(3)|stomach(3)|urinary_tract(1)	63				GBM - Glioblastoma multiforme(131;0.0407)		TTCAGGTGAAGTATTTGATTA	0.328000													43	13					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109577351	109577351	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:109577351C>T	ENST00000338432.7	+	2	260	c.141C>T	c.(139-141)ccC>ccT	p.P47P	ACACB_ENST00000377854.5_Silent_p.P47P|ACACB_ENST00000377848.3_Silent_p.P47P			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	47					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	GCCAGGAGCCCTTTCCAGCCT	0.557000													21	49					0	0	1	0	0
RS1	6247	broad.mit.edu	37	X	18660157	18660157	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:18660157C>T	ENST00000379984.3	-	6	682	c.642G>A	c.(640-642)atG>atA	p.M214I	RS1_ENST00000476595.1_5'UTR|CDKL5_ENST00000379989.3_Intron|CDKL5_ENST00000379996.3_Intron	NM_000330.3	NP_000321.1	O15537	XLRS1_HUMAN	retinoschisin 1	214	F5/8 type C.				cell adhesion|multicellular organismal development|response to stimulus|visual perception	extracellular space				cervix(1)|endometrium(4)|large_intestine(5)|lung(2)|ovary(2)|skin(1)	15	Hepatocellular(33;0.183)					CCAGCAGCTCCATCCGGATGG	0.677000													37	2					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35624458	35624458	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:35624458G>A	ENST00000287272.2	+	14	2165	c.2145G>A	c.(2143-2145)caG>caA	p.Q715Q	UNC5D_ENST00000420357.1_Silent_p.Q717Q|UNC5D_ENST00000404895.2_Silent_p.Q784Q|UNC5D_ENST00000416672.1_Silent_p.Q789Q|UNC5D_ENST00000449677.1_Silent_p.Q360Q|UNC5D_ENST00000453357.2_Silent_p.Q779Q			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	784	Interaction with DCC (By similarity).				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		GTAACCGGCAGCCCCTGCACT	0.587000													19	24					0	0	1	0	0
PUM1	9698	broad.mit.edu	37	1	31441268	31441268	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:31441268G>A	ENST00000373747.3	-	11	1680	c.1581C>T	c.(1579-1581)ccC>ccT	p.P527P	PUM1_ENST00000373742.2_Silent_p.P467P|PUM1_ENST00000257075.5_Silent_p.P526P|PUM1_ENST00000373741.4_Silent_p.P562P|PUM1_ENST00000424085.2_Silent_p.P284P|PUM1_ENST00000490546.1_5'UTR|PUM1_ENST00000440538.2_Silent_p.P527P|PUM1_ENST00000423018.2_Silent_p.P430P|PUM1_ENST00000426105.2_Silent_p.P526P	NM_001020658.1	NP_001018494.1	Q14671	PUM1_HUMAN	pumilio RNA-binding family member 1	526	Ala-rich.				cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(17)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		CTGCCACAAGGGGATCCGTTT	0.537000													66	24					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9048429	9048429	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:9048429C>T	ENST00000397910.4	-	5	33405	c.33202G>A	c.(33202-33204)Gaa>Aaa	p.E11068K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11070	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGTGTGGTTTCTAGTTCACCA	0.502000													16	54					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113649090	113649090	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:113649090C>T	ENST00000297405.5	-	22	3915	c.3671G>A	c.(3670-3672)gGt>gAt	p.G1224D	CSMD3_ENST00000352409.3_Missense_Mutation_p.G1224D|CSMD3_ENST00000343508.3_Missense_Mutation_p.G1184D|CSMD3_ENST00000455883.2_Missense_Mutation_p.G1120D	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1224	Sushi 6.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TCGGCCACCACCAAGACAGAT	0.512000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			32	40					0	0	1	0	0
APH1A	51107	broad.mit.edu	37	1	150238543	150238543	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:150238543G>A	ENST00000369109.3	-	7	973	c.785C>T	c.(784-786)cCa>cTa	p.P262L	APH1A_ENST00000414276.2_Missense_Mutation_p.P192L|APH1A_ENST00000360244.4_3'UTR	NM_001077628.2	NP_001071096.1	Q96BI3	APH1A_HUMAN	APH1A gamma secretase subunit	262					amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to plasma membrane	protein binding			breast(1)|lung(4)|ovary(1)|skin(1)|urinary_tract(2)	9	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GTCCTCGGGTGGGATGCGCAG	0.637000													5	13					0	0	1	0	0
HRC	3270	broad.mit.edu	37	19	49657810	49657810	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:49657810C>T	ENST00000252825.4	-	1	871	c.685G>A	c.(685-687)Gat>Aat	p.D229N	HRC_ENST00000595625.1_Missense_Mutation_p.D229N	NM_002152.2	NP_002143.1	P23327	SRCH_HUMAN	histidine rich calcium binding protein	229	4 X tandem repeats, acidic.|6 X approximate tandem repeats.				muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(10)|lung(10)|ovary(1)|prostate(3)|urinary_tract(2)	34		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		TGGTGTCCATCTGAGACATCC	0.537000													11	9					0	0	1	0	0
COQ9	57017	broad.mit.edu	37	16	57492195	57492195	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:57492195C>T	ENST00000262507.6	+	6	713	c.644C>T	c.(643-645)tCc>tTc	p.S215F	COQ9_ENST00000567933.1_Intron|COQ9_ENST00000567072.1_Missense_Mutation_p.S180F	NM_020312.3	NP_064708.1	O75208	COQ9_HUMAN	coenzyme Q9	215					ubiquinone biosynthetic process	mitochondrion				breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)	16						AACATCCCGTCCAGCCTGAGC	0.572000													6	7					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49433939	49433939	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:49433939G>A	ENST00000301067.7	-	31	7613	c.7614C>T	c.(7612-7614)ttC>ttT	p.F2538F		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CTGCCTGAGGGAAAGTGAAAC	0.637000													7	17					0	0	1	0	0
CDH24	64403	broad.mit.edu	37	14	23518287	23518287	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:23518287G>A	ENST00000397359.3	-	12	2168	c.1909C>T	c.(1909-1911)Ctc>Ttc	p.L637F	CDH24_ENST00000554034.1_Missense_Mutation_p.L599F|CDH24_ENST00000487137.2_Missense_Mutation_p.L599F|CDH24_ENST00000485922.1_5'UTR|CDH24_ENST00000267383.5_Missense_Mutation_p.L637F	NM_022478.3	NP_071923.2	Q86UP0	CAD24_HUMAN	cadherin 24, type 2	637					adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	26	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		CCGGTGCTGAGCCCAGCAGCT	0.637000													4	23					0	0	1	0	0
FUBP3	8939	broad.mit.edu	37	9	133507359	133507359	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:133507359C>T	ENST00000319725.9	+	15	1458	c.1383C>T	c.(1381-1383)ttC>ttT	p.F461F		NM_003934.1	NP_003925.1	Q96I24	FUBP3_HUMAN	far upstream element (FUSE) binding protein 3	461					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|RNA binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(10)|ovary(2)|urinary_tract(2)	21				OV - Ovarian serous cystadenocarcinoma(145;0.000279)		CCGGGTGCTTCCCAAACATGG	0.587000													16	51					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	124992888	124992888	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:124992888C>T	ENST00000522917.1	+	11	1453	c.1247C>T	c.(1246-1248)tCc>tTc	p.S416F	FER1L6_ENST00000399018.1_Missense_Mutation_p.S416F	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	416						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TCTAAATTTTCCAAGGCCCTG	0.458000											OREG0018964	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	46					0	0	1	0	0
AQP8	343	broad.mit.edu	37	16	25228627	25228627	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:25228627G>A	ENST00000219660.5	+	2	246	c.121G>A	c.(121-123)Gaa>Aaa	p.E41K	AQP8_ENST00000566125.1_Missense_Mutation_p.E35K	NM_001169.2	NP_001160.2	O94778	AQP8_HUMAN	aquaporin 8	41					cellular response to cAMP	integral to plasma membrane	water channel activity			NS(1)|breast(1)|large_intestine(3)|lung(8)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	16				GBM - Glioblastoma multiforme(48;0.044)		ATGTCTGGTCGAACTGCTGGG	0.617000													100	146					0	0	1	0	0
ZNF160	90338	broad.mit.edu	37	19	53577486	53577486	+	Silent	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:53577486A>G	ENST00000601421.1	-	2	946	c.70T>C	c.(70-72)Ttg>Ctg	p.L24L	ZNF160_ENST00000429604.1_Silent_p.L60L|ZNF160_ENST00000355147.5_Silent_p.L60L|ZNF160_ENST00000418871.1_Silent_p.L60L|ZNF160_ENST00000599056.1_Silent_p.L60L			Q9HCG1	ZN160_HUMAN	zinc finger protein 160	60	KRAB.				hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	35				GBM - Glioblastoma multiforme(134;0.02)		CCTTCCTCCAACATGGAGATA	0.443000													35	31					0	0	1	0	0
ZNF682	91120	broad.mit.edu	37	19	20117129	20117129	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:20117129C>T	ENST00000397165.2	-	4	1342	c.1182G>A	c.(1180-1182)gaG>gaA	p.E394E	ZNF682_ENST00000358523.5_Silent_p.E362E|ZNF682_ENST00000397162.1_Silent_p.E362E|ZNF682_ENST00000596019.1_Intron|ZNF682_ENST00000597972.1_Silent_p.E400E|ZNF682_ENST00000595736.1_Silent_p.E318E	NM_033196.2	NP_149973.1	O95780	ZN682_HUMAN	zinc finger protein 682	394					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	14						TGTAGGGTTTCTCTCCAGTGT	0.378000													21	23					0	0	1	0	0
TAS1R1	80835	broad.mit.edu	37	1	6631138	6631138	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:6631138C>T	ENST00000333172.6	+	2	554	c.361C>T	c.(361-363)Ctg>Ttg	p.L121L	TAS1R1_ENST00000351136.3_Silent_p.L121L|TAS1R1_ENST00000328191.4_Silent_p.L121L	NM_138697.3	NP_619642.2	Q7RTX1	TS1R1_HUMAN	taste receptor, type 1, member 1	121					sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(13)|ovary(1)|skin(1)|urinary_tract(2)	29	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		AGTGCTCTCCCTGCCAGGGCA	0.582000													82	128					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6167203	6167203	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:6167203G>A	ENST00000261405.5	-	14	1795	c.1541C>T	c.(1540-1542)cCc>cTc	p.P514L		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	514	VWFD 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	GGCATAGACGGGGGACAGCTG	0.567000													24	52					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50278642	50278642	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr18:50278642C>T	ENST00000442544.2	+	2	926	c.310C>T	c.(310-312)Cat>Tat	p.H104Y	DCC_ENST00000412726.1_5'UTR	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	104	Ig-like C2-type 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		AAACATACTTCATTCCAGACA	0.438000													22	42					0	0	1	0	0
ACTL7B	10880	broad.mit.edu	37	9	111618037	111618037	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:111618037G>A	ENST00000374667.3	-	1	1202	c.174C>T	c.(172-174)tcC>tcT	p.S58S		NM_006686.3	NP_006677.1	Q9Y614	ACL7B_HUMAN	actin-like 7B	58						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						TGCAGTACTGGGAGCCCAGGT	0.657000													76	77					0	0	1	0	0
MICALCL	84953	broad.mit.edu	37	11	12315139	12315139	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:12315139C>T	ENST00000256186.2	+	3	452	c.161C>T	c.(160-162)tCg>tTg	p.S54L		NM_032867.2	NP_116256.2	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	54	Ser-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(5)|lung(5)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	30				Epithelial(150;0.00177)		TCGCAAGTCTCGAGAGGTCAT	0.468000													48	154					0	0	1	0	0
SHISA3	152573	broad.mit.edu	37	4	42403140	42403140	+	Missense_Mutation	SNP	C	C	T	rs140353032	byFrequency	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:42403140C>T	ENST00000319234.4	+	2	607	c.389C>T	c.(388-390)tCg>tTg	p.S130L		NM_001080505.1	NP_001073974.1	A0PJX4	SHSA3_HUMAN	shisa family member 3	130					multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	12						AAGGAGCCCTCGCAGCAGCCA	0.582000													128	122					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52601629	52601629	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:52601629C>T	ENST00000395489.2	-	7	733	c.337G>A	c.(337-339)Gaa>Aaa	p.E113K	A1CF_ENST00000374001.1_Missense_Mutation_p.E120K|A1CF_ENST00000395495.1_Missense_Mutation_p.E120K|A1CF_ENST00000282641.2_Missense_Mutation_p.E120K|A1CF_ENST00000373997.3_Missense_Mutation_p.E120K|A1CF_ENST00000373993.1_Missense_Mutation_p.E120K|A1CF_ENST00000373995.3_Missense_Mutation_p.E128K	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	120	RRM 1.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						TACCTAATTTCATAATTATTA	0.318000													27	3					0	0	1	0	0
RASEF	158158	broad.mit.edu	37	9	85630815	85630815	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:85630815C>T	ENST00000376447.3	-	4	930	c.669_splice	c.e4-1	p.E224_splice		NM_152573.2	NP_689786.2	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	224					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(4)|liver(1)|lung(15)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	33						TTGCGTTTTTCCTAAAAGAAA	0.388000													28	79					0	0	1	0	0
VN1R4	317703	broad.mit.edu	37	19	53770138	53770138	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:53770138T>A	ENST00000311170.4	-	1	834	c.781A>T	c.(781-783)Aat>Tat	p.N261Y		NM_173857.2	NP_776256.2	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	261					response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			central_nervous_system(1)|large_intestine(4)|lung(10)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	22				GBM - Glioblastoma multiforme(134;0.00294)		CTATTGGGATTATCCAAAAGA	0.458000										HNSCC(26;0.072)			9	23					0	0	1	0	0
PRR23A	729627	broad.mit.edu	37	3	138724845	138724845	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:138724845C>T	ENST00000383163.2	-	1	265	c.266G>A	c.(265-267)cGa>cAa	p.R89Q	MRPS22_ENST00000495075.1_5'UTR	NM_001134659.1	NP_001128131.1	A6NEV1	PR23A_HUMAN	proline rich 23A	89										endometrium(3)|kidney(1)|lung(7)	11						GAGAGACACTCGCAGGATCGA	0.657000													6	14					0	0	1	0	0
MYBPH	4608	broad.mit.edu	37	1	203140584	203140584	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:203140584G>A	ENST00000255416.4	-	5	777	c.720C>T	c.(718-720)gaC>gaT	p.D240D		NM_004997.2	NP_004988.2	Q13203	MYBPH_HUMAN	myosin binding protein H	240	Ig-like C2-type 1.				cell adhesion|regulation of striated muscle contraction	myosin filament	structural constituent of muscle			endometrium(5)|large_intestine(6)|lung(7)|skin(1)|urinary_tract(1)	20			BRCA - Breast invasive adenocarcinoma(75;0.153)	Colorectal(1306;0.0306)		AGCGGCCAGAGTCGGAGCGCT	0.632000													10	54					0	0	1	0	0
SERPINB13	5275	broad.mit.edu	37	18	61262351	61262351	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr18:61262351T>C	ENST00000344731.5	+	7	806	c.704T>C	c.(703-705)aTt>aCt	p.I235T	SERPINB13_ENST00000269489.5_Intron	NM_012397.3	NP_036529.1	Q9UIV8	SPB13_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 13	235					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						ATTCTAGGGATTCCATATAAA	0.428000													43	53					0	0	1	0	0
CAPN3	825	broad.mit.edu	37	15	42702021	42702021	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr15:42702021C>T	ENST00000397163.3	+	18	2248	c.2029C>T	c.(2029-2031)Ctt>Ttt	p.L677F	CAPN3_ENST00000397200.4_Missense_Mutation_p.L165F|CAPN3_ENST00000397204.4_Missense_Mutation_p.L12F|CAPN3_ENST00000356316.3_Missense_Mutation_p.L584F|CAPN3_ENST00000318023.7_Missense_Mutation_p.L671F|CAPN3_ENST00000569136.1_Missense_Mutation_p.L12F|CAPN3_ENST00000349748.3_Missense_Mutation_p.L585F|RP11-164J13.1_ENST00000495723.1_RNA|CAPN3_ENST00000337571.4_Missense_Mutation_p.L12F|CAPN3_ENST00000357568.3_Missense_Mutation_p.L671F|CAPN3_ENST00000561817.1_Missense_Mutation_p.L12F|CAPN3_ENST00000562199.1_3'UTR	NM_000070.2	NP_000061.1	P20807	CAN3_HUMAN	calpain 3, (p94)	677	Domain IV.|EF-hand 1.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	47		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		CAAGAAGGTCCTTAACACAGT	0.547000													80	22					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9046338	9046338	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:9046338G>A	ENST00000397910.4	-	5	35496	c.35293C>T	c.(35293-35295)Cct>Tct	p.P11765S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11767	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGCATACCAGGAGAATGAGTC	0.468000													12	37					0	0	1	0	0
ATP8A1	10396	broad.mit.edu	37	4	42545975	42545975	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:42545975G>A	ENST00000381668.5	-	20	1912	c.1681C>T	c.(1681-1683)Cgc>Tgc	p.R561C	ATP8A1_ENST00000264449.10_Missense_Mutation_p.R546C	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	561					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	GATGGAGTGCGAACAATCACT	0.338000													17	11					0	0	1	0	0
ESRRB	2103	broad.mit.edu	37	14	76905809	76905809	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:76905809C>T	ENST00000380887.2	+	2	185	c.113C>T	c.(112-114)tCg>tTg	p.S38L	ESRRB_ENST00000261532.7_Missense_Mutation_p.S38L|ESRRB_ENST00000507951.1_3'UTR|ESRRB_ENST00000556177.1_Missense_Mutation_p.S38L|ESRRB_ENST00000509242.1_Missense_Mutation_p.S38L			A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	38						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(234;0.0213)		CCCAGTGGCTCGTCCGACGCC	0.701000													17	48					0	0	1	0	0
KLK14	43847	broad.mit.edu	37	19	51582847	51582847	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:51582847C>T	ENST00000391802.1	-	5	591	c.373G>A	c.(373-375)Gac>Aac	p.D125N	KLK14_ENST00000156499.2_Missense_Mutation_p.D125N	NM_022046.4	NP_071329.2	Q9P0G3	KLK14_HUMAN	kallikrein-related peptidase 14	125	Peptidase S1.				epidermis morphogenesis|fertilization|negative regulation of G-protein coupled receptor protein signaling pathway|positive regulation of G-protein coupled receptor protein signaling pathway|proteolysis|seminal clot liquefaction	extracellular space	serine-type endopeptidase activity			kidney(4)|large_intestine(1)|lung(4)|skin(1)|urinary_tract(1)	11		all_neural(266;0.0199)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00422)		AGGTCGTTGTCGTGGGTCCGG	0.667000													8	21					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183675573	183675573	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:183675573C>T	ENST00000511685.1	+	22	4176	c.4053C>T	c.(4051-4053)aaC>aaT	p.N1351N	TENM3_ENST00000406950.2_Silent_p.N1351N|TENM3_ENST00000502950.1_3'UTR					teneurin transmembrane protein 3																		TAGCCATTAACCCTATGGATA	0.423000													6	4					0	0	1	0	0
NUTM2A-AS1	728190	broad.mit.edu	37	10	88975774	88975774	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:88975774G>A	ENST00000451940.2	-	0	600																											GTTCTGCACCGCGGTCAGGCT	0.607000													8	5					0	0	1	0	0
CYTH2	9266	broad.mit.edu	37	19	48977536	48977536	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:48977536C>T	ENST00000427476.1	+	7	945	c.645C>T	c.(643-645)gcC>gcT	p.A215A	CYTH2_ENST00000452733.2_Silent_p.A215A	NM_004228.6|NM_017457.5	NP_004219.3|NP_059431.1	Q99418	CYH2_HUMAN	cytohesin 2	215					actin cytoskeleton organization|endocytosis|regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|membrane fraction|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15						GCTTTGTGGCCATGAACCGGG	0.637000													34	48					0	0	1	0	0
KIAA1257	57501	broad.mit.edu	37	3	128690107	128690107	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:128690107G>A	ENST00000265068.5	-	8	1358	c.1191C>T	c.(1189-1191)tcC>tcT	p.S397S	KIAA1257_ENST00000515659.1_Silent_p.S285S|RP11-723O4.6_ENST00000508239.1_Intron|KIAA1257_ENST00000511438.1_Intron	NM_020741.2	NP_065792.1	Q9ULG3	K1257_HUMAN	KIAA1257	397										breast(1)|endometrium(2)|large_intestine(3)|lung(6)|skin(2)	14						GGAGCTGCTGGGAACAGGGCA	0.612000											OREG0015784	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	14					0	0	1	0	0
TCL1A	8115	broad.mit.edu	37	14	96180290	96180290	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:96180290G>A	ENST00000402399.1	-	1	243	c.114C>T	c.(112-114)acC>acT	p.T38T	TCL1A_ENST00000556450.1_Silent_p.T38T|TCL1A_ENST00000554012.1_Silent_p.T38T|TCL1A_ENST00000555202.1_Silent_p.T38T|RP11-164H13.1_ENST00000553445.1_RNA|RP11-164H13.1_ENST00000547644.2_RNA	NM_021966.2	NP_068801.1	P56279	TCL1A_HUMAN	T-cell leukemia/lymphoma 1A	38					multicellular organismal development	endoplasmic reticulum|microsome				haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(5)|prostate(1)|skin(1)	12		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		GTACCTCGATGGTTAAGGGCA	0.642000			T	TRA@	T-CLL								29	77					0	0	1	0	0
PTGDR	5729	broad.mit.edu	37	14	52741455	52741455	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:52741455G>C	ENST00000306051.2	+	2	955	c.853G>C	c.(853-855)Gct>Cct	p.A285P	PTGDR_ENST00000553372.1_3'UTR	NM_000953.2	NP_000944.1	Q13258	PD2R_HUMAN	prostaglandin D2 receptor (DP)	285						integral to membrane|plasma membrane	prostaglandin D receptor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Breast(41;0.0639)|all_epithelial(31;0.0887)				Nedocromil(DB00716)	ACAGTATCGCGCTTACTATGG	0.393000													12	26					0	0	1	0	0
ATCAY	85300	broad.mit.edu	37	19	3907898	3907898	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:3907898G>A	ENST00000450849.2	+	5	992	c.525G>A	c.(523-525)atG>atA	p.M175I	ATCAY_ENST00000398448.3_Missense_Mutation_p.M181I|ATCAY_ENST00000301260.6_Missense_Mutation_p.M175I|ATCAY_ENST00000600960.1_Missense_Mutation_p.M175I	NM_033064.4	NP_149053.1	Q86WG3	ATCAY_HUMAN	ataxia, cerebellar, Cayman type	175	CRAL-TRIO.				transport		protein binding			breast(1)|endometrium(2)|kidney(2)|lung(2)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		GGCCTTACATGAAAGTGGTCA	0.677000													11	15					0	0	1	0	0
HTR3C	170572	broad.mit.edu	37	3	183778032	183778032	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:183778032G>A	ENST00000318351.1	+	9	1270	c.1236G>A	c.(1234-1236)atG>atA	p.M412I		NM_130770.2	NP_570126.2	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine (serotonin) receptor 3C, ionotropic	412						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(2)	32	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CCCAGCTAATGGAGCTGTGGG	0.597000													48	36					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	2027447	2027447	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:2027447G>A	ENST00000382722.5	-	1	555	c.193C>T	c.(193-195)Cct>Tct	p.P65S	CACNA2D4_ENST00000586184.1_Missense_Mutation_p.P65S|CACNA2D4_ENST00000587995.1_Missense_Mutation_p.P65S|RP5-1096D14.3_ENST00000544163.1_RNA|CACNA2D4_ENST00000585732.1_Missense_Mutation_p.P65S	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	65						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		CCCCACGCAGGGGACAGGGAG	0.622000													8	5					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24406673	24406673	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:24406673C>T	ENST00000330966.7	-	20	2584	c.2422G>A	c.(2422-2424)Gat>Aat	p.D808N	MYOM3_ENST00000374434.3_Missense_Mutation_p.D807N|MYOM3_ENST00000329601.7_Missense_Mutation_p.D807N|RP11-293P20.4_ENST00000429191.1_RNA|RP11-293P20.2_ENST00000439239.2_RNA			Q5VTT5	MYOM3_HUMAN	myomesin 3	807	Fibronectin type-III 5.									NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GCCCGTACATCGTACGGGGGG	0.602000													11	81					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128367568	128367568	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:128367568C>T	ENST00000389524.4	+	24	3222	c.3169C>T	c.(3169-3171)Cca>Tca	p.P1057S	MYO7B_ENST00000409816.2_Missense_Mutation_p.P1057S|MYO7B_ENST00000428314.1_Missense_Mutation_p.P1057S			Q6PIF6	MYO7B_HUMAN	myosin VIIB	1057	MyTH4 1.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		TGCCCAGGTTCCACAGCACAG	0.657000													9	5					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71509179	71509179	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:71509179G>A	ENST00000396073.3	+	9	2317	c.2036G>A	c.(2035-2037)gGa>gAa	p.G679E	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	679					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			AGCTTCAAAGGAGGCCCAACA	0.418000													22	49					0	0	1	0	0
TMCC2	9911	broad.mit.edu	37	1	205197873	205197873	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:205197873C>T	ENST00000358024.3	+	1	570	c.181C>T	c.(181-183)Ccc>Tcc	p.P61S		NM_014858.3	NP_055673.2	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	61						integral to membrane	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(3)|pancreas(1)|skin(1)|urinary_tract(1)	20	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			CAACCCAGGTCCCCGAAGCAA	0.682000													5	34					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152382699	152382699	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:152382699C>T	ENST00000427231.2	-	149	22225	c.22023G>A	c.(22021-22023)gcG>gcA	p.A7341A	NEB_ENST00000409198.1_Silent_p.A5640A|NEB_ENST00000603639.1_Silent_p.A7341A|NEB_ENST00000397345.3_Silent_p.A7341A|NEB_ENST00000604864.1_Silent_p.A7341A|NEB_ENST00000172853.10_Silent_p.A5640A	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	5640					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TGACAGTCTTCGCCAGCAGGA	0.552000													12	41					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25465684	25465684	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr15:25465684G>A	ENST00000424208.1	+	0	3039				SNHG14_ENST00000453082.2_RNA|SNORD115-27_ENST00000364430.1_RNA	NR_003305.1																						GAAAAGAGGTGATGACTTAAC	0.498000													65	22					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102476379	102476379	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:102476379C>T	ENST00000360184.4	+	30	6341	c.6177C>T	c.(6175-6177)ttC>ttT	p.F2059F		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	2059	AAA 1 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CACAGGGTTTCCGCACTGCTG	0.463000													55	41					0	0	1	0	0
OR7G1	125962	broad.mit.edu	37	19	9226086	9226086	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:9226086C>T	ENST00000293614.1	-	1	353	c.354G>A	c.(352-354)atG>atA	p.M118I	OR7G1_ENST00000541538.1_Missense_Mutation_p.M118I			Q8NGA0	OR7G1_HUMAN	olfactory receptor, family 7, subfamily G, member 1	118					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|skin(2)	20						GGTCGTAGGCCATGACTGCAA	0.488000													23	63					0	0	1	0	0
BCKDHB	594	broad.mit.edu	37	6	80877513	80877513	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:80877513C>T	ENST00000545529.1	+	4	490	c.462C>T	c.(460-462)ttC>ttT	p.F154F	BCKDHB_ENST00000320393.6_Silent_p.F154F|BCKDHB_ENST00000369760.4_Silent_p.F154F|BCKDHB_ENST00000356489.5_Silent_p.F154F			P21953	ODBB_HUMAN	branched chain keto acid dehydrogenase E1, beta polypeptide	154					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|carboxy-lyase activity|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(10)|upper_aerodigestive_tract(1)	15		all_cancers(76;1.38e-05)|Acute lymphoblastic leukemia(125;1.15e-05)|all_hematologic(105;0.00118)|all_epithelial(107;0.0149)		BRCA - Breast invasive adenocarcinoma(397;0.0291)		ATTATATTTTCCCTGCATTTG	0.413000													6	20					0	0	1	0	0
TLE2	7089	broad.mit.edu	37	19	3000675	3000675	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:3000675C>T	ENST00000262953.6	-	19	2356	c.2094G>A	c.(2092-2094)tgG>tgA	p.W698*	TLE2_ENST00000586422.1_Intron|TLE2_ENST00000455444.2_Nonsense_Mutation_p.W576*|TLE2_ENST00000447365.2_Nonsense_Mutation_p.W365*|TLE2_ENST00000443826.3_Nonsense_Mutation_p.W576*|TLE2_ENST00000426948.2_Intron|TLE2_ENST00000590536.1_Nonsense_Mutation_p.W699*|TLE2_ENST00000591529.1_Intron	NM_003260.4	NP_003251.2	Q04725	TLE2_HUMAN	transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)	698					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|prostate(1)	13				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGGCGTCCTCCAGGCGTTGA	0.642000													6	1					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157396738	157396738	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:157396738C>T	ENST00000389413.3	-	15	2390	c.2287G>A	c.(2287-2289)Gag>Aag	p.E763K	PTPRN2_ENST00000389416.4_Missense_Mutation_p.E775K|PTPRN2_ENST00000404321.2_Missense_Mutation_p.E815K|PTPRN2_ENST00000389418.4_Missense_Mutation_p.E792K|PTPRN2_ENST00000409483.1_Missense_Mutation_p.E754K	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	792	Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		TGGCTGTTCTCCGCCTTCAGC	0.632000													23	21					0	0	1	0	0
TRAPPC12	51112	broad.mit.edu	37	2	3392198	3392198	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:3392198C>T	ENST00000324266.5	+	2	999	c.804C>T	c.(802-804)ccC>ccT	p.P268P	TRAPPC12_ENST00000382110.2_Silent_p.P268P	NM_016030.5	NP_057114.5	Q8WVT3	TTC15_HUMAN	trafficking protein particle complex 12	268							binding										TGCGAGGGCCCCAGGCAGCTG	0.746000													4	15					0	0	1	0	0
BAIAP2L1	55971	broad.mit.edu	37	7	97935801	97935801	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:97935801C>T	ENST00000005260.8	-	11	1406	c.1191G>A	c.(1189-1191)acG>acA	p.T397T		NM_018842.4	NP_061330.2	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	397	SH3.				filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			NS(1)|breast(1)|cervix(1)|endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)	23	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)			CCAGCAACTTCGTGTACGACG	0.567000													23	61					0	0	1	0	0
OR1C1	26188	broad.mit.edu	37	1	247921066	247921066	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:247921066G>A	ENST00000408896.2	-	1	916	c.643C>T	c.(643-645)Ctc>Ttc	p.L215F		NM_012353.2	NP_036485.2	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C, member 1	215					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(32)|skin(2)|upper_aerodigestive_tract(1)	46	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TAAGATACGAGGATACAGACA	0.493000													20	12					0	0	1	0	0
TRIM39	56658	broad.mit.edu	37	6	30309562	30309562	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:30309562C>G	ENST00000376659.5	+	8	1591	c.993C>G	c.(991-993)ttC>ttG	p.F331L	TRIM39_ENST00000396548.1_Missense_Mutation_p.F331L|TRIM39-RPP21_ENST00000513556.1_Missense_Mutation_p.F243L|TRIM39_ENST00000396547.1_Missense_Mutation_p.F361L|TRIM39_ENST00000540416.1_Missense_Mutation_p.F331L|TRIM39_ENST00000396551.3_Missense_Mutation_p.F331L|TRIM39_ENST00000376656.4_Missense_Mutation_p.F361L	NM_172016.2	NP_742013.1			tripartite motif containing 39											ovary(3)	3						GCGTCAAGTTCGTGGAGACAA	0.572000													9	25					0	0	1	0	0
DDX60L	91351	broad.mit.edu	37	4	169300899	169300899	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:169300899G>A	ENST00000511577.1	-	31	4446	c.4199C>T	c.(4198-4200)tCc>tTc	p.S1400F	DDX60L_ENST00000260184.7_Missense_Mutation_p.S1400F			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1400							ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		GAGCTGCAAGGAAAACAAAAA	0.368000													5	17					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38647444	38647444	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:38647444C>T	ENST00000413689.1	-	10	1529	c.1336G>A	c.(1336-1338)Gag>Aag	p.E446K	SCN5A_ENST00000455624.2_Missense_Mutation_p.E446K|SCN5A_ENST00000451551.2_Missense_Mutation_p.E446K|SCN5A_ENST00000450102.2_Missense_Mutation_p.E446K|SCN5A_ENST00000443581.1_Missense_Mutation_p.E446K|SCN5A_ENST00000423572.2_Missense_Mutation_p.E446K|SCN5A_ENST00000425664.1_Missense_Mutation_p.E446K|SCN5A_ENST00000414099.2_Missense_Mutation_p.E446K|SCN5A_ENST00000449557.2_Missense_Mutation_p.E446K|SCN5A_ENST00000333535.4_Missense_Mutation_p.E446K	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	446					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TCACCCACCTCGTGTTCTTTC	0.562000													20	16					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144942717	144942717	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:144942717C>T	ENST00000525985.1	-	2	4776	c.4705G>A	c.(4705-4707)Gga>Aga	p.G1569R				P58107	EPIPL_HUMAN	epiplakin 1	1569						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AAGTTGCCTCCCTCCAGGGAC	0.642000													4	14					0	0	1	0	0
CCR8	1237	broad.mit.edu	37	3	39373938	39373938	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:39373938C>T	ENST00000326306.4	+	2	254	c.116C>T	c.(115-117)gCt>gTt	p.A39V	CCR8_ENST00000545843.1_Intron|CCR8_ENST00000414803.1_Intron	NM_005201.3	NP_005192.1	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	39					cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			NS(3)|breast(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		TTGCTCCTTGCTGTCTTTTAT	0.478000													42	35					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60885242	60885242	+	Missense_Mutation	SNP	C	C	T	rs139502000	byFrequency	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:60885242C>T	ENST00000252999.3	-	77	10792	c.10726G>A	c.(10726-10728)Gag>Aag	p.E3576K		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	3576	Laminin G-like 5.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACTTGCTTCTCGGTCACCTGC	0.657000													46	37					0	0	1	0	0
MBD4	8930	broad.mit.edu	37	3	129152780	129152780	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:129152780G>A	ENST00000429544.2	-	5	1501	c.1306C>T	c.(1306-1308)Cgg>Tgg	p.R436W	MBD4_ENST00000507208.1_Missense_Mutation_p.R442W|MBD4_ENST00000509587.1_5'UTR|MBD4_ENST00000503197.1_Missense_Mutation_p.R442W|MBD4_ENST00000393278.2_Missense_Mutation_p.R124W|MBD4_ENST00000249910.1_Missense_Mutation_p.R442W	NM_001276270.1	NP_001263199.1	O95243	MBD4_HUMAN	methyl-CpG binding domain protein 4	442					depyrimidination	nucleoplasm	DNA N-glycosylase activity|endodeoxyribonuclease activity|protein binding|satellite DNA binding			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)	22						AAAGGTGACCGAGGAGGTGTC	0.403000								Base excision repair (BER), DNA glycosylases					30	33					0	0	1	0	0
SETD1A	9739	broad.mit.edu	37	16	30972806	30972806	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:30972806C>T	ENST00000262519.8	+	4	1151	c.465C>T	c.(463-465)ctC>ctT	p.L155L		NM_014712.1	NP_055527.1	O15047	SET1A_HUMAN	SET domain containing 1A	155	RRM.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(21)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	59						TCAAAAACCTCCACCTTACCT	0.602000													28	46					0	0	1	0	0
ZFP64	55734	broad.mit.edu	37	20	50701678	50701678	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:50701678G>A	ENST00000361387.2	-	9	1416	c.1356C>T	c.(1354-1356)acC>acT	p.T452T	ZFP64_ENST00000371523.4_Silent_p.T233T|ZFP64_ENST00000371518.2_Intron	NM_199427.2	NP_955459.2	Q9NPA5	ZF64A_HUMAN	ZFP64 zinc finger protein	435					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(5)|large_intestine(8)|lung(11)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	33						TCGCCTTCATGGTGCAGCGGA	0.562000													63	44					0	0	1	0	0
WIZ	58525	broad.mit.edu	37	19	15536418	15536418	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:15536418G>A	ENST00000389282.4	-	7	4027	c.3814C>T	c.(3814-3816)Ctc>Ttc	p.L1272F	WIZ_ENST00000599910.1_Missense_Mutation_p.L589F|WIZ_ENST00000263381.6_Missense_Mutation_p.L415F|WIZ_ENST00000545156.1_Missense_Mutation_p.L586F|WIZ_ENST00000599686.2_Missense_Mutation_p.L456F			O95785	WIZ_HUMAN	widely interspaced zinc finger motifs	1272						nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	24						TTCTTCTTGAGGATCTCTCGC	0.657000													14	18					0	0	1	0	0
THEMIS	387357	broad.mit.edu	37	6	128134908	128134908	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:128134908C>T	ENST00000368250.1	-	5	1139	c.641G>A	c.(640-642)gGa>gAa	p.G214E	THEMIS_ENST00000368248.2_Missense_Mutation_p.G293E|THEMIS_ENST00000537166.1_Missense_Mutation_p.G258E|THEMIS_ENST00000543064.1_Missense_Mutation_p.G293E			Q8N1K5	THMS1_HUMAN	thymocyte selection associated	293	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(3)	60						CAGGTGGTTTCCTTCAGGTGC	0.403000													22	58					0	0	1	0	0
PEX5L	51555	broad.mit.edu	37	3	179593220	179593220	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:179593220C>T	ENST00000467460.1	-	6	881	c.551G>A	c.(550-552)gGa>gAa	p.G184E	PEX5L_ENST00000472994.1_Missense_Mutation_p.G125E|PEX5L_ENST00000468741.1_5'UTR|PEX5L_ENST00000476138.1_Missense_Mutation_p.G141E|PEX5L_ENST00000465751.1_Missense_Mutation_p.G160E|PEX5L_ENST00000464614.1_Missense_Mutation_p.G76E|PEX5L-AS1_ENST00000466064.1_RNA|PEX5L_ENST00000263962.8_Missense_Mutation_p.G182E|PEX5L_ENST00000392649.3_Missense_Mutation_p.G76E|PEX5L_ENST00000467440.2_5'UTR|PEX5L_ENST00000485199.1_Missense_Mutation_p.G149E	NM_001256751.1|NM_016559.2	NP_001243680.1|NP_057643.1	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	184					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			ATTTCGATCTCCATGAAACTT	0.453000													39	16					0	0	1	0	0
TMEM108	66000	broad.mit.edu	37	3	133099172	133099172	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:133099172C>T	ENST00000515826.1	+	3	740	c.617C>T	c.(616-618)cCt>cTt	p.P206L	TMEM108_ENST00000393130.3_Missense_Mutation_p.P206L|TMEM108_ENST00000508711.1_Intron|TMEM108_ENST00000321871.6_Missense_Mutation_p.P206L			Q6UXF1	TM108_HUMAN	transmembrane protein 108	206						integral to membrane				endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						AGCTCCACACCTCTGGGGCAG	0.592000													13	21					0	0	1	0	0
TKTL2	84076	broad.mit.edu	37	4	164393463	164393463	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:164393463C>T	ENST00000280605.3	-	1	1584	c.1424G>A	c.(1423-1425)cGa>cAa	p.R475Q		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	475						cytoplasm	metal ion binding|transketolase activity	p.R475Q(1)		breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TTGGCTGGTTCGAATGAAGCA	0.453000													30	46					0	0	1	0	0
WDR78	79819	broad.mit.edu	37	1	67301343	67301343	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:67301343G>A	ENST00000371026.3	-	11	1754	c.1699C>T	c.(1699-1701)Cgg>Tgg	p.R567W	WDR78_ENST00000431318.1_Missense_Mutation_p.R313W	NM_024763.4	NP_079039.4	Q5VTH9	WDR78_HUMAN	WD repeat domain 78	567										NS(1)|endometrium(3)|kidney(6)|large_intestine(6)|lung(10)|ovary(3)|skin(3)	32						CTGTTGCTCCGTACATTGTAA	0.373000													17	90					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160106421	160106421	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:160106421C>T	ENST00000361216.3	+	19	2714	c.2625C>T	c.(2623-2625)ttC>ttT	p.F875F	ATP1A2_ENST00000392233.3_Silent_p.F875F|ATP1A2_ENST00000472488.1_3'UTR	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	875					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			AGAACGGTTTCCTGCCATCAC	0.582000													80	30					0	0	1	0	0
REL	5966	broad.mit.edu	37	2	61145543	61145543	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:61145543C>T	ENST00000295025.7	+	7	975	c.655C>T	c.(655-657)Cgt>Tgt	p.R219C	REL_ENST00000394479.3_Missense_Mutation_p.R219C	NM_002908.2	NP_002899.1	Q04864	REL_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog	219	RHD.				positive regulation of I-kappaB kinase/NF-kappaB cascade	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(3)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	16	all_hematologic(2;0.0797)	Ovarian(717;0.0728)	LUSC - Lung squamous cell carcinoma(5;6.2e-08)|Lung(5;1.65e-06)|Epithelial(17;0.064)|all cancers(80;0.221)			CATAGAAGTTCGTTTTGTGTT	0.323000			A		Hodgkin Lymphoma								24	50					0	0	1	0	0
CTDSPL2	51496	broad.mit.edu	37	15	44778815	44778815	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr15:44778815C>T	ENST00000260327.4	+	4	955	c.392C>T	c.(391-393)tCc>tTc	p.S131F	CTDSPL2_ENST00000396780.1_Missense_Mutation_p.S131F|CTDSPL2_ENST00000558373.1_Missense_Mutation_p.S131F|CTDSPL2_ENST00000558966.1_Missense_Mutation_p.S131F	NM_016396.2	NP_057480.2	Q05D32	CTSL2_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2	131							phosphoprotein phosphatase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(2)	13		all_cancers(109;4.36e-14)|all_epithelial(112;9.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;1.02e-20)|GBM - Glioblastoma multiforme(94;1.49e-06)|COAD - Colon adenocarcinoma(120;0.0857)|Colorectal(105;0.0905)		GATAATCCTTCCTCTGGCAGT	0.328000													56	12					0	0	1	0	0
DCAF8L2	347442	broad.mit.edu	37	X	27766188	27766188	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:27766188G>A	ENST00000451261.2	+	5	1575	c.1176G>A	c.(1174-1176)agG>agA	p.R392R		NM_001136533.1	NP_001130005.1			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|endometrium(9)|kidney(3)|lung(7)|pancreas(1)|skin(3)	24						AGTTTGTAAGGATTTATGACC	0.373000													14	6					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61823307	61823307	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:61823307G>A	ENST00000577390.1	-	8	2311	c.1357C>T	c.(1357-1359)Cca>Tca	p.P453S	CDH8_ENST00000299345.6_Missense_Mutation_p.P453S|CDH8_ENST00000584337.1_Missense_Mutation_p.P453S|CDH8_ENST00000577730.1_Missense_Mutation_p.P453S	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	453	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		CTGTCAAGTGGTGTTGCCAGC	0.428000													17	34					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	13098368	13098368	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:13098368G>A	ENST00000399002.2	+	8	1422	c.1148G>A	c.(1147-1149)aGg>aAg	p.R383K	SPTLC3_ENST00000378194.4_Intron	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	383					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	ATAGCTGGAAGGAAGGTAAGA	0.483000													25	55					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134108517	134108517	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:134108517C>T	ENST00000220616.4	+	43	7512	c.7472C>T	c.(7471-7473)cCt>cTt	p.P2491L	SLA_ENST00000518565.1_Intron|TG_ENST00000377869.1_Missense_Mutation_p.P2434L|SLA_ENST00000338087.5_Intron|SLA_ENST00000395352.3_Intron|SLA_ENST00000524345.1_Intron|TG_ENST00000519543.1_Missense_Mutation_p.P624L|TG_ENST00000542445.1_Missense_Mutation_p.P861L|SLA_ENST00000517648.1_Intron	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2491					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CTCCGTGAGCCTCCAGCCAGA	0.547000													91	140					0	0	1	0	0
AIFM3	150209	broad.mit.edu	37	22	21328366	21328366	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:21328366G>A	ENST00000399167.2	+	5	610	c.370G>A	c.(370-372)Ggt>Agt	p.G124S	AIFM3_ENST00000405089.1_Missense_Mutation_p.G130S|AIFM3_ENST00000333607.6_Missense_Mutation_p.G124S|AIFM3_ENST00000335375.5_Missense_Mutation_p.G112S|AIFM3_ENST00000399163.2_Missense_Mutation_p.G124S|AIFM3_ENST00000440238.2_Missense_Mutation_p.G124S	NM_144704.2	NP_653305.1			apoptosis-inducing factor, mitochondrion-associated, 3											breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	21	all_cancers(11;3.71e-26)|all_epithelial(7;1.59e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0367)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TCTGTCCCGTGGTCGGGTGCG	0.667000													12	20					0	0	1	0	0
ATP10A	57194	broad.mit.edu	37	15	26026306	26026306	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr15:26026306G>A	ENST00000356865.6	-	2	625	c.514C>T	c.(514-516)Cgc>Tgc	p.R172C		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	172					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		TCGTTGCAGCGAAGACGCACA	0.493000													35	7					0	0	1	0	0
TACR3	6870	broad.mit.edu	37	4	104510894	104510894	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:104510894G>A	ENST00000304883.2	-	5	1483	c.1343C>T	c.(1342-1344)tCc>tTc	p.S448F	RP11-297P16.3_ENST00000512401.1_RNA|RP11-297P16.3_ENST00000502936.1_RNA	NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	448						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		TGAAGTGGCGGAGGCAGATTT	0.473000													32	66					0	0	1	0	0
KIAA1024	23251	broad.mit.edu	37	15	79748566	79748566	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr15:79748566C>A	ENST00000305428.3	+	2	152	c.77C>A	c.(76-78)tCt>tAt	p.S26Y		NM_015206.2	NP_056021.1	Q9UPX6	K1024_HUMAN	KIAA1024	26						integral to membrane				central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(2)|pancreas(2)|prostate(1)	49						AATACCGTTTCTTATCAGGAC	0.473000													44	9					3.77016e-25	3.84307e-25	1	1	0
GON4L	54856	broad.mit.edu	37	1	155796745	155796745	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:155796745G>A	ENST00000437809.1	-	3	702	c.580C>T	c.(580-582)Cag>Tag	p.Q194*	GON4L_ENST00000368331.1_Nonsense_Mutation_p.Q194*|GON4L_ENST00000271883.5_Nonsense_Mutation_p.Q194*|GON4L_ENST00000361040.5_Nonsense_Mutation_p.Q194*|GON4L_ENST00000471341.1_5'UTR			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	194					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TTCCTGGGCTGGCTTACTGGT	0.483000													71	22					0	0	1	0	0
HRASLS	57110	broad.mit.edu	37	3	192973492	192973492	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:192973492G>A	ENST00000264735.2	+	2	462	c.368G>A	c.(367-369)gGg>gAg	p.G123E	HRASLS_ENST00000602513.1_Missense_Mutation_p.G18E	NM_020386.4	NP_065119.2	Q9HDD0	HRSL1_HUMAN	HRAS-like suppressor	18										breast(1)|large_intestine(2)|lung(4)|prostate(1)|skin(2)	10	all_cancers(143;9.1e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000159)		CCCTGCCCAGGGGACTTGATC	0.463000													47	44					0	0	1	0	0
CD96	10225	broad.mit.edu	37	3	111296379	111296379	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:111296379C>T	ENST00000283285.5	+	4	705	c.574C>T	c.(574-576)Ctt>Ttt	p.L192F	CD96_ENST00000438817.2_Intron|CD96_ENST00000352690.4_Intron	NM_198196.2	NP_937839.1	P40200	TACT_HUMAN	CD96 molecule	192	Ig-like V-type 2.				cell adhesion|immune response|regulation of immune response	integral to plasma membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(4)|liver(2)|lung(14)|skin(5)	35						TTGGGTCCTTCTTTCTAAGGG	0.403000									Opitz Trigonocephaly syndrome				50	58					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73457934	73457934	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:73457934G>A	ENST00000377110.2	-	5	1029	c.786C>T	c.(784-786)gaC>gaT	p.D262D	TRPM3_ENST00000358082.3_Silent_p.D109D|TRPM3_ENST00000396285.1_Silent_p.D109D|TRPM3_ENST00000396292.4_Silent_p.D109D|TRPM3_ENST00000357533.2_Silent_p.D264D|TRPM3_ENST00000396280.5_Silent_p.D109D|TRPM3_ENST00000396283.1_Silent_p.D109D|TRPM3_ENST00000360823.2_Silent_p.D109D|TRPM3_ENST00000377101.1_Silent_p.D109D|TRPM3_ENST00000377106.1_Silent_p.D109D|TRPM3_ENST00000377111.2_Silent_p.D262D|TRPM3_ENST00000423814.3_Silent_p.D264D|TRPM3_ENST00000377097.3_Silent_p.D109D|TRPM3_ENST00000377105.1_Silent_p.D109D|TRPM3_ENST00000361823.5_Silent_p.D109D|TRPM3_ENST00000408909.2_Silent_p.D109D	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	262						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						TTCCAATGAGGTCCTCCTGGT	0.443000													17	10					0	0	1	0	0
CD1E	913	broad.mit.edu	37	1	158324322	158324322	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:158324322G>A	ENST00000368160.3	+	2	214	c.214G>A	c.(214-216)Ggc>Agc	p.G72S	CD1E_ENST00000368155.3_Missense_Mutation_p.G72S|CD1E_ENST00000368164.3_Intron|CD1E_ENST00000368167.3_Missense_Mutation_p.G72S|CD1E_ENST00000368154.1_Intron|CD1E_ENST00000452291.2_Intron|CD1E_ENST00000434258.1_Missense_Mutation_p.G70S|CD1E_ENST00000368156.1_Missense_Mutation_p.G72S|CD1E_ENST00000368165.3_Missense_Mutation_p.G72S|CD1E_ENST00000464822.1_Intron|CD1E_ENST00000368161.3_Missense_Mutation_p.G72S|CD1E_ENST00000444681.2_Intron|CD1E_ENST00000368157.1_Intron|CD1E_ENST00000368166.3_Intron|CD1E_ENST00000368163.3_Missense_Mutation_p.G72S	NM_001042583.2	NP_001036048.1	P15812	CD1E_HUMAN	CD1e molecule	72					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					CACTGTCTTGGGCACCATCCG	0.517000													60	22					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940609	144940609	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:144940609G>A	ENST00000525985.1	-	2	6884	c.6813C>T	c.(6811-6813)ttC>ttT	p.F2271F				P58107	EPIPL_HUMAN	epiplakin 1	2271						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGTCGATGACGAAGCCGGTGG	0.716000													8	126					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1995415	1995415	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:1995415C>T	ENST00000382722.5	-	8	1329	c.967G>A	c.(967-969)Gag>Aag	p.E323K	CACNA2D4_ENST00000586184.1_Missense_Mutation_p.E323K|CACNA2D4_ENST00000588077.1_Missense_Mutation_p.E259K|CACNA2D4_ENST00000585708.1_Missense_Mutation_p.E259K|CACNA2D4_ENST00000587995.1_Missense_Mutation_p.E323K|CACNA2D4_ENST00000585732.1_Intron	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	323	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		AAGTCATTCTCCCCCAGGGTG	0.478000													16	20					0	0	1	0	0
ACAP1	9744	broad.mit.edu	37	17	7247260	7247260	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:7247260G>A	ENST00000158762.3	+	8	860	c.654G>A	c.(652-654)aaG>aaA	p.K218K	ACAP1_ENST00000573893.1_3'UTR	NM_014716.3	NP_055531.1	Q15027	ACAP1_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	218	BAR.|Required for formation of endosomal tubules when overexpressed with PIP5K1C.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			NS(1)|breast(5)|cervix(3)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|prostate(3)|skin(1)|urinary_tract(1)	33						AGTATCGAAAGGAGCTGGGCG	0.652000													9	4					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17056389	17056389	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:17056389C>T	ENST00000443236.1	-	22	2935	c.2904G>A	c.(2902-2904)gtG>gtA	p.V968V		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	921						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						TGACGTGATCCACCCCGATGG	0.597000													28	21					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40368695	40368695	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:40368695C>T	ENST00000221347.6	-	28	12660	c.12653G>A	c.(12652-12654)gGt>gAt	p.G4218D		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4218	VWFD 10.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GTCCATGTTACCGCAGAGCCC	0.617000													25	201					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139712376	139712376	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:139712376G>A	ENST00000303045.6	-	32	3017	c.2571C>T	c.(2569-2571)ttC>ttT	p.F857F	COL22A1_ENST00000435777.1_Silent_p.F857F|COL22A1_ENST00000341807.4_5'UTR	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	857	Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GATGTGGTGTGAACAGGGATG	0.527000										HNSCC(7;0.00092)			3	8					0	0	1	0	0
ATF3	467	broad.mit.edu	37	1	212792763	212792763	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:212792763G>A	ENST00000341491.4	+	4	677	c.412G>A	c.(412-414)Gag>Aag	p.E138K	ATF3_ENST00000366987.2_Missense_Mutation_p.E138K|ATF3_ENST00000366985.1_Missense_Mutation_p.E81K|ATF3_ENST00000366983.1_3'UTR|ATF3_ENST00000492118.1_3'UTR	NM_001040619.2|NM_001206488.2|NM_001674.3	NP_001035709.1|NP_001193417.2|NP_001665.1	P18847	ATF3_HUMAN	activating transcription factor 3	138	Leucine-zipper.					nucleolus	identical protein binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)	6				OV - Ovarian serous cystadenocarcinoma(81;0.00628)|all cancers(67;0.0097)|GBM - Glioblastoma multiforme(131;0.0388)|Epithelial(68;0.0933)		GCTCAAGAACGAGAAGCAGCA	0.498000													84	18					0	0	1	0	0
CLEC18C	283971	broad.mit.edu	37	16	70211332	70211332	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:70211332C>T	ENST00000569347.2	+	3	659	c.405C>T	c.(403-405)agC>agT	p.S135S	CLEC18C_ENST00000314151.8_Silent_p.S135S|CLEC18C_ENST00000541793.2_Silent_p.S135S|CLEC18C_ENST00000536907.2_Silent_p.S135S|CLEC18C_ENST00000561612.1_Intron	NM_173619.2	NP_775890.2			C-type lectin domain family 18, member C											endometrium(3)|large_intestine(6)|lung(1)	10						AGCGGTACAGCCACGCGGCAG	0.632000													9	76					0	0	1	0	0
DNAJC22	79962	broad.mit.edu	37	12	49745267	49745267	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:49745267C>T	ENST00000549441.2	+	4	2212	c.1008C>T	c.(1006-1008)ccC>ccT	p.P336P	DNAJC22_ENST00000395069.3_Silent_p.P336P			Q8N4W6	DJC22_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 22	336	J.				protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|liver(2)|lung(1)|ovary(1)|pancreas(1)	10						CCAGGAAGCCCTGGGGATCCC	0.567000													8	17					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31323748	31323748	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr18:31323748C>T	ENST00000269197.5	+	12	3936	c.3936C>T	c.(3934-3936)tcC>tcT	p.S1312S		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1312	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						CAGAGGGCTCCAGCATATCAA	0.443000													48	80					0	0	1	0	0
CD1B	910	broad.mit.edu	37	1	158300713	158300713	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:158300713G>A	ENST00000368168.3	-	2	308	c.201C>T	c.(199-201)ttC>ttT	p.F67F		NM_001764.2	NP_001755.1	P29016	CD1B_HUMAN	CD1b molecule	67					antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			breast(2)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	30	all_hematologic(112;0.0378)					AAGGCTTCAGGAATATGGCAG	0.468000													296	96					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	13074168	13074168	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:13074168C>T	ENST00000399002.2	+	6	1044	c.770C>T	c.(769-771)tCg>tTg	p.S257L	SPTLC3_ENST00000378194.4_Missense_Mutation_p.S257L	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	257					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	AACCACACATCGCTTGTGCTT	0.408000													18	74					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215855595	215855595	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:215855595G>A	ENST00000272895.7	-	24	3674	c.3455C>T	c.(3454-3456)tCg>tTg	p.S1152L	ABCA12_ENST00000389661.4_Missense_Mutation_p.S834L	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1152					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GCTGTAGTCCGAAAAATACAG	0.388000													8	69					0	0	1	0	0
SLC41A1	254428	broad.mit.edu	37	1	205766063	205766063	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:205766063G>T	ENST00000367137.3	-	8	2075	c.1061C>A	c.(1060-1062)cCt>cAt	p.P354H	SLC41A1_ENST00000468057.1_5'UTR	NM_173854.4	NP_776253.3	Q8IVJ1	S41A1_HUMAN	solute carrier family 41 (magnesium transporter), member 1	354						integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	17	Breast(84;0.0799)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			ATTAATCACAGGCGTGAAGAC	0.507000													7	19					0.00307968	0.0030883	1	1	0
TOP1MT	116447	broad.mit.edu	37	8	144408428	144408428	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:144408428G>A	ENST00000523676.1	-	5	558	c.153C>T	c.(151-153)gcC>gcT	p.A51A	TOP1MT_ENST00000521193.1_Silent_p.A51A|TOP1MT_ENST00000329245.4_Silent_p.A149A|TOP1MT_ENST00000519148.1_Silent_p.A51A			Q969P6	TOP1M_HUMAN	topoisomerase (DNA) I, mitochondrial	149					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			endometrium(5)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	23	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	TCCGGGCTGCGGCCTTGTCCA	0.587000													52	84					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179606123	179606123	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:179606123G>A	ENST00000589042.1	-	48	12061	c.11837C>T	c.(11836-11838)cCa>cTa	p.P3946L	TTN_ENST00000460472.2_Missense_Mutation_p.P3583L|TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.P3775L|TTN_ENST00000359218.5_Missense_Mutation_p.P3708L|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P3629L|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000590773.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3629							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAGCGAATTGGTTTTAACTC	0.483000													122	57					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36189078	36189078	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:36189078T>G	ENST00000303965.4	-	8	2162	c.1673A>C	c.(1672-1674)aAa>aCa	p.K558T		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	558	PH 1.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						CTCACCTTCTTTTTCTACTCT	0.289000													8	9					0	0	1	0	0
USP9X	8239	broad.mit.edu	37	X	41043859	41043859	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:41043859C>T	ENST00000324545.7	+	23	4122	c.3489C>T	c.(3487-3489)ggC>ggT	p.G1163G	USP9X_ENST00000378308.2_Silent_p.G1163G	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	1163					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						CTGCCATTGGCTATGGTCATG	0.423000													10	1					0	0	1	0	0
SHE	126669	broad.mit.edu	37	1	154456717	154456717	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:154456717C>T	ENST00000304760.2	-	6	1482	c.1396G>A	c.(1396-1398)Gaa>Aaa	p.E466K		NM_001010846.2	NP_001010846.1	Q5VZ18	SHE_HUMAN	Src homology 2 domain containing E	466	SH2.									breast(4)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(2)|pancreas(1)	14	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			TGTACCACTTCAGGGATGCTG	0.443000													4	39					0	0	1	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37536552	37536552	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:37536552G>A	ENST00000299824.1	+	9	1191	c.1002G>A	c.(1000-1002)cgG>cgA	p.R334R	PPP1R16B_ENST00000373331.2_Silent_p.R292R	NM_015568.2	NP_056383.1	Q96T49	PP16B_HUMAN	protein phosphatase 1, regulatory subunit 16B	334					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(23)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	49		Myeloproliferative disorder(115;0.00878)				CCTTGAGCCGGAGGACCTCCA	0.602000													23	53					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142572876	142572876	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:142572876C>T	ENST00000359396.3	-	9	1409	c.1164G>A	c.(1162-1164)ggG>ggA	p.G388G		NM_018646.3	NP_061116.2	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	388					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					TCACCAGCTCCCCGACCAGCC	0.562000													21	63					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14542653	14542653	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr18:14542653C>T	ENST00000358970.5	-	1	492	c.493G>A	c.(493-495)Gac>Aac	p.D165N	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	165										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						TTGTTCATGTCCGTGTCCCTG	0.592000													44	79					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115527431	115527431	+	Missense_Mutation	SNP	G	G	A	rs147186440		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:115527431G>A	ENST00000369522.3	+	30	2885	c.2645G>A	c.(2644-2646)aGa>aAa	p.R882K	SYCP1_ENST00000369518.1_Missense_Mutation_p.R882K|SYCP1_ENST00000477590.1_Intron	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	882					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAAAAAAAGAGAAAAATGGCC	0.254000													13	83					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70903897	70903897	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:70903897C>T	ENST00000413157.2	-	13	2103	c.1624G>A	c.(1624-1626)Gaa>Aaa	p.E542K	ADD2_ENST00000355733.3_Intron|ADD2_ENST00000264436.3_Intron|ADD2_ENST00000430656.1_Missense_Mutation_p.E558K|ADD2_ENST00000407644.2_Intron	NM_017482.3	NP_059516.2	P35612	ADDB_HUMAN	adducin 2 (beta)	543					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						AAACACGTTTCCCCGCCAGTC	0.637000													32	11					0	0	1	0	0
SLC16A10	117247	broad.mit.edu	37	6	111543257	111543257	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:111543257G>A	ENST00000368850.3	+	5	911	c.425G>A	c.(424-426)gGa>gAa	p.G142E	SLC16A10_ENST00000368851.5_Missense_Mutation_p.G456E			Q8TF71	MOT10_HUMAN	solute carrier family 16 (aromatic amino acid transporter), member 10	456					aromatic amino acid transport|cellular nitrogen compound metabolic process|ion transport	basolateral plasma membrane|integral to membrane	amino acid transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|prostate(2)	12		all_cancers(87;0.00172)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0313)|Colorectal(196;0.0466)		OV - Ovarian serous cystadenocarcinoma(136;0.0703)|Epithelial(106;0.12)|all cancers(137;0.132)		TACCTCGCTGGAGTCCCTCCC	0.468000													19	53					0	0	1	0	0
TAOK2	9344	broad.mit.edu	37	16	29999175	29999175	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:29999175C>T	ENST00000308893.4	+	16	4625	c.3582C>T	c.(3580-3582)atC>atT	p.I1194I	TAOK2_ENST00000279394.3_Intron|TAOK2_ENST00000543033.1_Silent_p.I1081I|TAOK2_ENST00000416441.2_Silent_p.I1021I	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	1194					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						CCACCCGAATCCCCCGGCTAC	0.711000													13	15					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156814378	156814378	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:156814378C>T	ENST00000368195.3	-	14	3009	c.2613G>A	c.(2611-2613)gcG>gcA	p.A871A	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	871	Fibronectin type-III 3.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCCCAAACTTCGCATATCGAA	0.597000													19	36					0	0	1	0	0
LILRA2	11027	broad.mit.edu	37	19	55086255	55086255	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:55086255G>A	ENST00000251377.3	+	5	543	c.410G>A	c.(409-411)gGg>gAg	p.G137E	LILRA2_ENST00000391737.1_Missense_Mutation_p.G125E|LILRA2_ENST00000251376.3_Missense_Mutation_p.G137E|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA2_ENST00000391738.3_Missense_Mutation_p.G137E|LILRA2_ENST00000495786.1_3'UTR|LILRB1_ENST00000448689.1_Intron					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		ACCTTAGGAGGGAACGTGACC	0.557000													38	81					0	0	1	0	0
CHGA	1113	broad.mit.edu	37	14	93397784	93397784	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:93397784A>G	ENST00000216492.5	+	6	825	c.545A>G	c.(544-546)aAc>aGc	p.N182S	CHGA_ENST00000334654.4_Intron|CHGA_ENST00000553866.1_3'UTR	NM_001275.3	NP_001266.1	P10645	CMGA_HUMAN	chromogranin A (parathyroid secretory protein 1)	182	O-glycosylated at one site only in cerebrospinal fluid.				regulation of blood pressure	extracellular region|stored secretory granule				cervix(1)|large_intestine(1)|lung(3)|skin(3)	8		all_cancers(154;0.0843)		Epithelial(152;0.102)|COAD - Colon adenocarcinoma(157;0.208)|all cancers(159;0.224)		gaggCCACCAACACCCACCCT	0.672000													4	21					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103412838	103412838	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:103412838G>A	ENST00000361246.2	-	28	4003	c.3715C>T	c.(3715-3717)Ctc>Ttc	p.L1239F		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	1239					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		GCCTTGATGAGAGGCAGCGAG	0.562000													16	17					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152473196	152473196	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:152473196G>A	ENST00000367255.5	-	134	24811	c.24210C>T	c.(24208-24210)aaC>aaT	p.N8070N	SYNE1_ENST00000347037.5_5'UTR|SYNE1_ENST00000356820.4_Silent_p.N2594N|SYNE1_ENST00000354674.4_Silent_p.N225N|SYNE1_ENST00000448038.1_Silent_p.N7999N|SYNE1_ENST00000423061.1_Silent_p.N7999N|SYNE1_ENST00000539504.1_Silent_p.N225N|SYNE1_ENST00000265368.4_Silent_p.N8070N|SYNE1_ENST00000341594.5_Silent_p.N7682N	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8070					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AATCAGTGCGGTTCTCCCTGG	0.557000										HNSCC(10;0.0054)			15	31					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63447746	63447746	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:63447746G>A	ENST00000322893.7	-	6	1054	c.786C>T	c.(784-786)atC>atT	p.I262I	KCNH5_ENST00000420622.2_Silent_p.I262I|KCNH5_ENST00000394964.2_Silent_p.I204I|KCNH5_ENST00000394968.1_Silent_p.I204I	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	262					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		AATTTAAAACGATGTCAACCA	0.423000													12	36					0	0	1	0	0
PTCHD3	374308	broad.mit.edu	37	10	27687295	27687295	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:27687295G>A	ENST00000438700.3	-	4	2349	c.2232C>T	c.(2230-2232)atC>atT	p.I744I		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	744					spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						GGGAAGAAATGATTTCATTTG	0.308000													21	2					0	0	1	0	0
TRIM42	287015	broad.mit.edu	37	3	140401926	140401926	+	Missense_Mutation	SNP	G	G	A	rs149885263		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:140401926G>A	ENST00000286349.3	+	2	1155	c.964G>A	c.(964-966)Gac>Aac	p.D322N		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	322						intracellular	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						CAATGGCCACGACACCATTAG	0.557000													33	30					0	0	1	0	0
B4GALNT1	2583	broad.mit.edu	37	12	58024787	58024787	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:58024787G>A	ENST00000341156.4	-	4	1050	c.466C>T	c.(466-468)Ccc>Tcc	p.P156S	B4GALNT1_ENST00000552350.1_Missense_Mutation_p.P156S|B4GALNT1_ENST00000449184.3_Missense_Mutation_p.P156S|B4GALNT1_ENST00000550764.1_Missense_Mutation_p.P156S|B4GALNT1_ENST00000418555.2_Missense_Mutation_p.P101S	NM_001478.3	NP_001469.1	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	156					lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|urinary_tract(1)	20	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			CTCCTGAGGGGCTGAACTTCC	0.632000													15	19					0	0	1	0	0
PTK7	5754	broad.mit.edu	37	6	43109933	43109933	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:43109933C>T	ENST00000230419.4	+	13	2164	c.1943C>T	c.(1942-1944)tCc>tTc	p.S648F	PTK7_ENST00000481273.1_Missense_Mutation_p.S656F|PTK7_ENST00000352931.2_Intron|PTK7_ENST00000349241.2_Missense_Mutation_p.S518F|PTK7_ENST00000345201.2_Missense_Mutation_p.S608F	NM_002821.4	NP_002812.2	Q13308	PTK7_HUMAN	protein tyrosine kinase 7	648	Ig-like C2-type 7.				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(12)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			CAGAATGGCTCCCTGGTGATC	0.627000													52	32					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146805363	146805363	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:146805363C>T	ENST00000361727.3	+	5	1191	c.675C>T	c.(673-675)atC>atT	p.I225I		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	225	Laminin G-like 1.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			AAGGAGTAATCCTGCACGGAG	0.403000										HNSCC(39;0.1)			18	12					0	0	1	0	0
PIP5K1C	23396	broad.mit.edu	37	19	3656499	3656499	+	Silent	SNP	G	G	A	rs144166425		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:3656499G>A	ENST00000335312.3	-	6	613	c.525C>T	c.(523-525)tcC>tcT	p.S175S	PIP5K1C_ENST00000589578.1_Silent_p.S175S|PIP5K1C_ENST00000537021.1_Silent_p.S175S|PIP5K1C_ENST00000587482.1_5'UTR|PIP5K1C_ENST00000539785.1_Silent_p.S175S	NM_001195733.1|NM_012398.2	NP_001182662.1|NP_036530.1	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	175	PIPK.				axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			large_intestine(3)|ovary(1)|skin(3)|stomach(2)	9		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		CGTAGAAGAGGGAGCCACTGG	0.622000													18	51					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48619145	48619145	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:48619145C>T	ENST00000328333.8	-	48	4823	c.4716G>A	c.(4714-4716)ggG>ggA	p.G1572G	COL7A1_ENST00000454817.1_Silent_p.G1572G	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1572	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TTACCCGTTCCCCTTGGACTC	0.582000													25	108					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73047456	73047456	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:73047456G>A	ENST00000604411.1	+	0	35417				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						TAAAACGAACGAGAAGGGGAA	0.398000													9	0					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43905651	43905651	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:43905651C>T	ENST00000562955.1	+	50	6971	c.6971C>T	c.(6970-6972)gCc>gTc	p.A2324V	SZT2_ENST00000372442.1_Missense_Mutation_p.A1482V	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	2381						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						GCTCGCCAGGCCCTGGCCGAT	0.572000													36	55					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54537682	54537682	+	Splice_Site	SNP	G	G	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:54537682G>T	ENST00000474759.1	+	5	592		c.e5+1		CACNA2D3_ENST00000288197.5_Splice_Site|CACNA2D3_ENST00000490478.1_Splice_Site|CACNA2D3_ENST00000415676.2_Splice_Site	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3							integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TACAACAAAGGTAAGACTCCC	0.428000													5	14					0.014758	0.014791	1	1	0
PIEZO2	63895	broad.mit.edu	37	18	10680308	10680308	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr18:10680308C>T	ENST00000302079.6	-	47	7311	c.7312G>A	c.(7312-7314)Gga>Aga	p.G2438R	PIEZO2_ENST00000503781.3_Missense_Mutation_p.G2501R|PIEZO2_ENST00000538948.1_Missense_Mutation_p.G458R|PIEZO2_ENST00000580640.1_Missense_Mutation_p.G2526R|PIEZO2_ENST00000581680.1_5'UTR|PIEZO2_ENST00000285141.4_Missense_Mutation_p.G293R			Q9H5I5	PIEZ2_HUMAN	piezo-type mechanosensitive ion channel component 2	2501						integral to membrane	ion channel activity										TTTGAGTTTCCTTCCAGTTCT	0.388000													20	21					0	0	1	0	0
USP6	9098	broad.mit.edu	37	17	5058900	5058900	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:5058900C>T	ENST00000574788.1	+	31	5057	c.2828_splice	c.e31+1	p.R943_splice	USP6_ENST00000332776.4_3'UTR|USP6_ENST00000304328.5_Splice_Site_p.R626_splice|USP6_ENST00000250066.6_Splice_Site_p.R943_splice			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	943					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						TGCCCAGGATCGGTGAGTTCA	0.448000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								40	5					0	0	1	0	0
TBX10	347853	broad.mit.edu	37	11	67399163	67399163	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:67399163C>T	ENST00000335385.3	-	8	1158	c.1071G>A	c.(1069-1071)agG>agA	p.R357R		NM_005995.4	NP_005986.2	O75333	TBX10_HUMAN	T-box 10	357					anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|lung(4)|ovary(1)	7						CTCCTTGATCCCTATCAGCCC	0.652000													5	8					0	0	1	0	0
ATMIN	23300	broad.mit.edu	37	16	81077931	81077931	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:81077931C>T	ENST00000566488.1	+	3	2323	c.1360C>T	c.(1360-1362)Cgt>Tgt	p.R454C	ATMIN_ENST00000539819.1_3'UTR|ATMIN_ENST00000564241.1_Missense_Mutation_p.R454C|ATMIN_ENST00000299575.4_Missense_Mutation_p.R610C			O43313	ATMIN_HUMAN	ATM interactor	610					response to DNA damage stimulus	nucleus	zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	20						ATTGGATCATCGTAGTCTTTT	0.433000													21	19					0	0	1	0	0
SRD5A3	79644	broad.mit.edu	37	4	56230311	56230311	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:56230311C>T	ENST00000264228.4	+	3	663	c.435C>T	c.(433-435)ttC>ttT	p.F145F	SRD5A3-AS1_ENST00000433175.2_RNA|SRD5A3_ENST00000514398.1_3'UTR	NM_024592.4	NP_078868.1	Q9H8P0	PORED_HUMAN	steroid 5 alpha-reductase 3	145					androgen biosynthetic process|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|polyprenol catabolic process	endoplasmic reticulum membrane|integral to membrane	3-oxo-5-alpha-steroid 4-dehydrogenase activity|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	p.F145F(2)		cervix(1)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	12	all_cancers(7;0.0308)|all_lung(4;0.00195)|Lung NSC(11;0.00431)|all_epithelial(27;0.0425)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.0179)			GAAGACTCTTCGAGTGCCTCT	0.478000													21	65					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38885853	38885853	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:38885853C>T	ENST00000359357.3	+	68	10064	c.9810C>T	c.(9808-9810)ctC>ctT	p.L3270L	DNAH8_ENST00000449981.2_Silent_p.L3487L|DNAH8_ENST00000441566.1_Silent_p.L3234L					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TGGCTGGTCTCCTGTCTTGGA	0.368000													12	38					0	0	1	0	0
ZMYM2	7750	broad.mit.edu	37	13	20625720	20625720	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:20625720C>T	ENST00000382869.3	+	13	2691	c.2440C>T	c.(2440-2442)Cct>Tct	p.P814S	ZMYM2_ENST00000382874.2_Missense_Mutation_p.P814S|ZMYM2_ENST00000382883.3_Missense_Mutation_p.P296S|ZMYM2_ENST00000382870.2_Missense_Mutation_p.P194S|ZMYM2_ENST00000382871.2_Missense_Mutation_p.P814S	NM_001190965.1|NM_003453.3|NM_197968.2	NP_001177894.1|NP_003444.1|NP_932072.1	Q9UBW7	ZMYM2_HUMAN	zinc finger, MYM-type 2	814					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	10		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		TCAGAAAGGACCTGAAAACTT	0.373000													16	14					0	0	1	0	0
HAVCR1	26762	broad.mit.edu	37	5	156479463	156479463	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:156479463C>T	ENST00000339252.3	-	3	1114	c.582G>A	c.(580-582)acG>acA	p.T194T	HAVCR1_ENST00000544197.1_Silent_p.T194T|HAVCR1_ENST00000425854.1_Silent_p.T194T|HAVCR1_ENST00000522693.1_Silent_p.T194T|HAVCR1_ENST00000523175.1_Silent_p.T194T	NM_012206.2	NP_036338.2	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	189	11 X 6 AA approximate tandem repeats of V-P-T-T-T-T].|Thr-rich.				interspecies interaction between organisms	integral to membrane	receptor activity	p.T194T(1)		endometrium(3)|large_intestine(2)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTGGAATGCTCGTTGTCGTTG	0.463000													175	49					0	0	1	0	0
TSSC2	650368	broad.mit.edu	37	11	3423084	3423084	+	RNA	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:3423084C>T	ENST00000529482.1	+	0	673																											CACGCACTCTCCGTTCAGGGC	0.587000													10	9					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20976118	20976118	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:20976118C>T	ENST00000261383.3	-	53	9087	c.9088G>A	c.(9088-9090)Gac>Aac	p.D3030N	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3030					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		ATGACCTTGTCCTTACATTCA	0.527000													12	28					0	0	1	0	0
OR10G8	219869	broad.mit.edu	37	11	123901064	123901064	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:123901064C>T	ENST00000431524.1	+	1	768	c.735C>T	c.(733-735)atC>atT	p.I245I		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	245					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.I245I(1)		breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CCCACTGTATCGTGGTCCTTT	0.537000													16	43					0	0	1	0	0
ZNF714	148206	broad.mit.edu	37	19	21300279	21300279	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:21300279C>T	ENST00000596143.1	+	5	1134	c.809C>T	c.(808-810)gCc>gTc	p.A270V	ZNF714_ENST00000601416.1_3'UTR|ZNF714_ENST00000291770.7_3'UTR|ZNF714_ENST00000596053.1_Intron	NM_182515.3	NP_872321.2	Q96N38	ZN714_HUMAN	zinc finger protein 714	271					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|urinary_tract(2)	18						CACCCTTCAGCCCTTACTACA	0.358000													4	19					0	0	1	0	0
ARHGEF26	26084	broad.mit.edu	37	3	153840463	153840463	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:153840463C>T	ENST00000356448.4	+	2	966	c.682C>T	c.(682-684)Ctc>Ttc	p.L228F	ARHGEF26_ENST00000465093.1_Missense_Mutation_p.L228F|ARHGEF26_ENST00000465817.1_Missense_Mutation_p.L228F	NM_001251962.1	NP_001238891.1	Q96DR7	ARHGQ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 26	228					regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	23						GAACGAGCTCCTCGAGAATCC	0.557000													11	13					0	0	1	0	0
AMICA1	120425	broad.mit.edu	37	11	118081247	118081247	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:118081247A>T	ENST00000292067.7	-	3	790	c.349T>A	c.(349-351)Ttc>Atc	p.F117I	AMICA1_ENST00000526620.1_Missense_Mutation_p.F88I|AMICA1_ENST00000533261.1_Missense_Mutation_p.F127I|AMICA1_ENST00000356289.5_Missense_Mutation_p.F127I	NM_153206.2	NP_694938.2	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen 1	127	Ig-like V-type 1.				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane				central_nervous_system(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|stomach(2)	20	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		GCCTTCTTGAACACCTGGCTC	0.517000													12	29					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140263981	140263981	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:140263981C>T	ENST00000289272.2	+	1	2128	c.2128C>T	c.(2128-2130)Ctg>Ttg	p.L710L	PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA13_ENST00000409494.1_Silent_p.L710L|PCDHA8_ENST00000531613.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGTCCAGCCTGTTGGTGCT	0.647000													70	27					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072808	17072808	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:17072808C>T	ENST00000359963.3	-	1	892	c.633G>A	c.(631-633)ggG>ggA	p.G211G		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	211					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CCTCCAGTGTCCCCCCGGGCA	0.607000													41	67					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131912262	131912262	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:131912262G>A	ENST00000359827.3	-	7	2792	c.1830C>T	c.(1828-1830)atC>atT	p.I610I	PLXNA4_ENST00000321063.4_Silent_p.I610I			Q9HCM2	PLXA4_HUMAN	plexin A4	610						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						AGTAGCACTGGATCTGATTGC	0.587000													22	19					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43905575	43905575	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:43905575C>T	ENST00000562955.1	+	50	6895	c.6895C>T	c.(6895-6897)Cga>Tga	p.R2299*	SZT2_ENST00000372442.1_Nonsense_Mutation_p.R1457*	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	2356						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						CCCACGGCTTCGATTGGATGT	0.562000													13	60					0	0	1	0	0
SMPD4	55627	broad.mit.edu	37	2	130910667	130910667	+	Silent	SNP	G	G	A	rs146485657	byFrequency	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:130910667G>A	ENST00000409031.1	-	19	3368	c.2220C>T	c.(2218-2220)atC>atT	p.I740I	SMPD4_ENST00000452225.2_Silent_p.I481I|SMPD4_ENST00000431183.2_Silent_p.I638I|SMPD4_ENST00000339679.7_Silent_p.I598I|SMPD4_ENST00000351288.6_Silent_p.I711I|SMPD4_ENST00000426662.2_Silent_p.I376I|SMPD4_ENST00000443958.2_Silent_p.I404I|SMPD4_ENST00000453750.1_Silent_p.I489I	NM_017951.4	NP_060421.2	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)	701					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(17)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	CCAAGCTGGCGATCTCATAGC	0.572000													22	99					0	0	1	0	0
SLC26A9	115019	broad.mit.edu	37	1	205890814	205890814	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:205890814G>A	ENST00000367135.3	-	17	2048	c.1935C>T	c.(1933-1935)gcC>gcT	p.A645A	SLC26A9_ENST00000340781.4_Silent_p.A645A|SLC26A9_ENST00000367134.2_Silent_p.A645A	NM_052934.3	NP_443166.1	Q7LBE3	S26A9_HUMAN	solute carrier family 26 (anion exchanger), member 9	645	STAS.					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			NS(1)|breast(3)|endometrium(11)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|skin(7)|urinary_tract(5)	52	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			GCTCGCCGGGGGCCTCAGCGG	0.627000													12	2					0	0	1	0	0
CTHRC1	115908	broad.mit.edu	37	8	104394720	104394720	+	Silent	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:104394720A>G	ENST00000330295.5	+	4	766	c.624A>G	c.(622-624)ttA>ttG	p.L208L	CTHRC1_ENST00000520337.1_Silent_p.L194L|CTHRC1_ENST00000520880.1_Silent_p.L78L	NM_138455.3	NP_612464.1	Q96CG8	CTHR1_HUMAN	collagen triple helix repeat containing 1	208						collagen				endometrium(1)|large_intestine(5)|lung(4)|ovary(1)|urinary_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)			GTGCTGGATTAGTGGATGTTG	0.373000													79	83					0	0	1	0	0
FBLN1	2192	broad.mit.edu	37	22	45960844	45960844	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:45960844G>A	ENST00000348697.2	+	15	1925	c.1778G>A	c.(1777-1779)gGg>gAg	p.G593E	FBLN1_ENST00000442170.2_Missense_Mutation_p.G593E|FBLN1_ENST00000327858.6_Intron			P23142	FBLN1_HUMAN	fibulin 1	589					interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	30		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		TGGAAGCAGGGGTTGGAGGAT	0.552000													16	12					0	0	1	0	0
CD6	923	broad.mit.edu	37	11	60785414	60785414	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:60785414C>T	ENST00000313421.7	+	11	1952	c.1766C>T	c.(1765-1767)tCt>tTt	p.S589F	CD6_ENST00000344028.5_Missense_Mutation_p.S557F|CD6_ENST00000452451.2_Missense_Mutation_p.S548F|CD6_ENST00000346437.4_Missense_Mutation_p.S516F|CD6_ENST00000352009.5_Missense_Mutation_p.S557F	NM_006725.4	NP_006716.3	P30203	CD6_HUMAN	CD6 molecule	589					cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)	18						CAGGTGTTTTCTTCAGAGAGG	0.572000													26	54					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73963876	73963876	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:73963876C>T	ENST00000373468.1	-	3	1167	c.516G>A	c.(514-516)agG>agA	p.R172R	KIAA2022_ENST00000055682.5_Silent_p.R172R			Q5QGS0	K2022_HUMAN	KIAA2022	172					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						TTTCATAATCCCTATTTAGAT	0.453000													30	5					0	0	1	0	0
FKBP5	2289	broad.mit.edu	37	6	35565179	35565179	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:35565179G>A	ENST00000542713.1	-	6	668	c.511C>T	c.(511-513)Cac>Tac	p.H171Y	FKBP5_ENST00000539068.1_Missense_Mutation_p.H171Y|FKBP5_ENST00000540787.1_5'UTR|FKBP5_ENST00000357266.4_Missense_Mutation_p.H171Y|FKBP5_ENST00000536438.1_Missense_Mutation_p.H171Y	NM_001145777.1	NP_001139249.1	Q13451	FKBP5_HUMAN	FK506 binding protein 5	171	PPIase FKBP-type 2.				protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(3)|urinary_tract(2)	17						CCTTCCAGGTGGACTGAGGGC	0.488000													13	38					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32753925	32753925	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:32753925C>T	ENST00000380250.3	+	23	3481	c.2985C>T	c.(2983-2985)tcC>tcT	p.S995S		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	995					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		GAACAAATTCCCTTGTTTTCA	0.388000													32	65					0	0	1	0	0
LGSN	51557	broad.mit.edu	37	6	63990693	63990693	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:63990693C>T	ENST00000370657.4	-	4	796	c.763G>A	c.(763-765)Gag>Aag	p.E255K	LGSN_ENST00000370658.5_Intron			Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase domain	255					glutamine biosynthetic process		glutamate-ammonia ligase activity			NS(1)|endometrium(2)|large_intestine(5)|lung(16)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	34					L-Glutamic Acid(DB00142)	GAAAAACTCTCGACATTGGCT	0.418000													9	17					0	0	1	0	0
ATF4P4	100127952	broad.mit.edu	37	11	113660422	113660422	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:113660422G>A	ENST00000393544.2	+	0	470																											ACCTGTGTGAGAAAGACCTGA	0.567000													8	7					0	0	1	0	0
SNTG2	54221	broad.mit.edu	37	2	1079206	1079206	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:1079206G>A	ENST00000308624.5	+	2	204	c.75G>A	c.(73-75)acG>acA	p.T25T	SNTG2_ENST00000407292.1_Silent_p.T25T	NM_018968.3	NP_061841.2	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	25					central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding	p.T25T(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		CCCTACAGACGAAAACCACTA	0.478000													42	24					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43846406	43846406	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:43846406C>T	ENST00000389420.3	-	13	1852	c.1853G>A	c.(1852-1854)cGa>cAa	p.R618Q	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.R618Q	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	618	Cys-rich.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CTGCTTCTCTCGAAAGTCTTG	0.423000													6	20					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35740308	35740308	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:35740308C>T	ENST00000440995.2	+	23	3254	c.3254C>T	c.(3253-3255)tCc>tTc	p.S1085F	CTD-2113L7.1_ENST00000510433.1_RNA|SPEF2_ENST00000356031.3_Missense_Mutation_p.S1090F			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1090					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GATTTCAACTCCCTTCCTGAT	0.438000													84	14					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166847987	166847987	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:166847987C>T	ENST00000423058.2	-	26	5815	c.5798G>A	c.(5797-5799)cGa>cAa	p.R1933Q	SCN1A_ENST00000303395.4_Missense_Mutation_p.R1933Q|SCN1A_ENST00000375405.3_Missense_Mutation_p.R1922Q|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Missense_Mutation_p.R1905Q|AC010127.3_ENST00000597623.1_RNA	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1933						voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.R1922Q(1)		NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TTTTACAGTTCGCTTTAAAAG	0.353000													30	44					0	0	1	0	0
ATF5	22809	broad.mit.edu	37	19	50436081	50436081	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:50436081C>T	ENST00000423777.2	+	3	958	c.581C>T	c.(580-582)cCt>cTt	p.P194L	CTC-326K19.6_ENST00000451973.1_Intron|ATF5_ENST00000595125.1_Missense_Mutation_p.P194L	NM_001193646.1	NP_001180575.1	Q9Y2D1	ATF5_HUMAN	activating transcription factor 5	194	Interaction with PTP4A1 (By similarity).|Poly-Pro.				regulation of transcription from RNA polymerase II promoter	cytoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			NS(1)|endometrium(2)|large_intestine(1)|skin(3)	7		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00221)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		CCACCTCAACCTTCTCGCCTG	0.657000													3	6					0	0	1	0	0
NUP98	4928	broad.mit.edu	37	11	3712680	3712680	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:3712680G>A	ENST00000324932.7	-	28	4771	c.4351C>T	c.(4351-4353)Cct>Tct	p.P1451S	NUP98_ENST00000359171.4_Missense_Mutation_p.P1451S|NUP98_ENST00000355260.3_Missense_Mutation_p.P1451S	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	1468					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity	p.P1451S(1)		NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		AGATACGAAGGAAGTGGGGAG	0.428000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								5	22					0	0	1	0	0
UGT2B28	54490	broad.mit.edu	37	4	70146488	70146488	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:70146488C>T	ENST00000335568.5	+	1	272	c.270C>T	c.(268-270)atC>atT	p.I90I	UGT2B28_ENST00000511240.1_Silent_p.I90I	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	90					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	AGAATATCATCATGCAACAGG	0.328000													26	19					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	14277324	14277324	+	RNA	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:14277324C>T	ENST00000310358.7	+	0	1759							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		TCGAGAGAATCGCACGGAAGG	0.537000													10	24					0	0	1	0	0
COL8A1	1295	broad.mit.edu	37	3	99513481	99513481	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:99513481G>A	ENST00000261037.3	+	5	1116	c.736G>A	c.(736-738)Ggg>Agg	p.G246R	COL8A1_ENST00000273342.4_Missense_Mutation_p.G246R	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	246	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						CAAGGGCTTCGGGATGCCAGG	0.627000													28	98					0	0	1	0	0
NEUROD1	4760	broad.mit.edu	37	2	182543375	182543375	+	Silent	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:182543375T>C	ENST00000295108.3	-	2	670	c.213A>G	c.(211-213)gaA>gaG	p.E71E	CERKL_ENST00000479558.1_Intron|NEUROD1_ENST00000496876.1_Intron	NM_002500.4	NP_002491.2	Q13562	NDF1_HUMAN	neuronal differentiation 1	71	Glu-rich (acidic).|Poly-Glu.				amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.088)			cctcttcctcttcttcctcct	0.532000													8	25					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176659435	176659435	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:176659435C>T	ENST00000367662.3	+	5	3464	c.2300C>T	c.(2299-2301)aCg>aTg	p.T767M	PAPPA2_ENST00000367661.3_Missense_Mutation_p.T767M	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	767					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TCCATGGAAACGGGAGACCTC	0.567000													94	51					0	0	1	0	0
BTN3A3	10384	broad.mit.edu	37	6	26448586	26448586	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:26448586G>C	ENST00000244519.2	+	6	1069	c.826G>C	c.(826-828)Gaa>Caa	p.E276Q	BTN3A3_ENST00000361232.3_Missense_Mutation_p.E234Q|BTN3A3_ENST00000339789.4_Missense_Mutation_p.E234Q	NM_006994.4	NP_008925.1	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3	276						integral to membrane				cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	30						ACAACAGAAGGAAAAAATTGC	0.532000													7	67					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10364096	10364096	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:10364096C>T	ENST00000377093.4	+	21	3006	c.2853C>T	c.(2851-2853)atC>atT	p.I951I	KIF1B_ENST00000377081.1_Intron|KIF1B_ENST00000377083.1_Silent_p.I951I|KIF1B_ENST00000377086.1_Intron|KIF1B_ENST00000263934.6_Intron	NM_183416.3	NP_904325.2	O60333	KIF1B_HUMAN	kinesin family member 1B	0					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding	p.I951I(1)		breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		ATAGGTTCATCCCTCCTGAGA	0.488000													21	119					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26414335	26414335	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:26414335T>A	ENST00000265944.5	+	19	2078	c.1912T>A	c.(1912-1914)Ttg>Atg	p.L638M	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	638	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						AGGTGCTTCTTTGCTTTGCAT	0.408000													22	4					0	0	1	0	0
ANKFN1	162282	broad.mit.edu	37	17	54526448	54526448	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:54526448G>A	ENST00000566473.2	+	10	1117	c.1117G>A	c.(1117-1119)Gac>Aac	p.D373N	ANKFN1_ENST00000318698.2_Missense_Mutation_p.D373N			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	373										NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						AGACTGGAAAGACTATGACGA	0.488000													28	7					0	0	1	0	0
ROBO4	54538	broad.mit.edu	37	11	124765416	124765416	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:124765416G>A	ENST00000306534.3	-	6	1458	c.973C>T	c.(973-975)Cca>Tca	p.P325S	ROBO4_ENST00000533054.1_Missense_Mutation_p.P180S	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	325	Fibronectin type-III 1.				angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CCAGAGGATGGTCTCACTTTG	0.632000													20	60					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22661206	22661206	+	RNA	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:22661206T>C	ENST00000426066.1	+	0	298					NR_027293.1																						AGCTGAATCATGCAGAATTTG	0.408000													7	45					0	0	1	0	0
OR13C3	138803	broad.mit.edu	37	9	107298801	107298801	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:107298801G>A	ENST00000374781.2	-	1	336	c.294C>T	c.(292-294)ttC>ttT	p.F98F		NM_001001961.1	NP_001001961.1	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C, member 3	98					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(1)|skin(1)	19						AGATATCCAGGAAAGAGAGGT	0.413000													13	32					0	0	1	0	0
CDCP1	64866	broad.mit.edu	37	3	45152210	45152210	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:45152210A>T	ENST00000296129.1	-	4	913	c.779T>A	c.(778-780)cTg>cAg	p.L260Q	CDCP1_ENST00000425231.2_Missense_Mutation_p.L260Q	NM_022842.3	NP_073753.3	Q9H5V8	CDCP1_HUMAN	CUB domain containing protein 1	260						extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|skin(4)|urinary_tract(1)	29				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		GCTGGCCCGCAGGTGTGCAGG	0.572000													34	100					0	0	1	0	0
CSAD	51380	broad.mit.edu	37	12	53566413	53566413	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:53566413G>A	ENST00000267085.4	-	5	460	c.227C>T	c.(226-228)cCt>cTt	p.P76L	CSAD_ENST00000379846.1_Intron|CSAD_ENST00000542115.1_Missense_Mutation_p.P49L|CSAD_ENST00000491654.1_5'UTR|CSAD_ENST00000453446.2_Missense_Mutation_p.P49L|CSAD_ENST00000379843.3_Intron|CSAD_ENST00000444623.1_Missense_Mutation_p.P49L	NM_001244706.1|NM_015989.4	NP_001231635.1|NP_057073.4	Q9Y600	CSAD_HUMAN	cysteine sulfinic acid decarboxylase	49					carboxylic acid metabolic process		pyridoxal phosphate binding|sulfinoalanine decarboxylase activity			kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(4)	14					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	CAGCTCCTCAGGCTCCTTCCA	0.607000													5	6					0	0	1	0	0
CERKL	375298	broad.mit.edu	37	2	182521722	182521722	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:182521722C>T	ENST00000410087.3	-	1	112	c.12G>A	c.(10-12)agG>agA	p.R4R	CERKL_ENST00000374970.2_Silent_p.R4R|CERKL_ENST00000409440.3_Silent_p.R4R|CERKL_ENST00000339098.5_Silent_p.R4R|CERKL_ENST00000479558.1_Intron|CERKL_ENST00000374969.2_Silent_p.R4R	NM_001030311.2|NM_201548.4	NP_001025482.1|NP_963842.1	Q49MI3	CERKL_HUMAN	ceramide kinase-like	4					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|Golgi apparatus|nucleolus	diacylglycerol kinase activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(13)|ovary(3)|skin(3)	32			OV - Ovarian serous cystadenocarcinoma(117;0.088)			TCCTGCGCCTCCTCCAGGGCA	0.746000													9	11					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42795611	42795611	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:42795611C>T	ENST00000572681.2	+	11	5486	c.5418C>T	c.(5416-5418)ccC>ccT	p.P1806P	CIC_ENST00000160740.3_Silent_p.P897P|CIC_ENST00000575354.2_Silent_p.P897P			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	897					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				CCGCCCCACCCCCCAAAGGTG	0.617000			"""Mis, F, S"""		oligodendroglioma								48	55					0	0	1	0	0
PRIM2	5558	broad.mit.edu	37	6	57246934	57246934	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:57246934G>T	ENST00000607273.1	+	7	748	c.661G>T	c.(661-663)Gaa>Taa	p.E221*	PRIM2_ENST00000389488.2_3'UTR	NM_000947.2	NP_000938.2	P49643	PRI2_HUMAN	primase, DNA, polypeptide 2 (58kDa)	221					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(34)|prostate(6)|stomach(4)|upper_aerodigestive_tract(1)	59				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		CATCCTGAATGAATTTAGAGC	0.393000													6	51					8.12818e-05	8.1738e-05	1	1	0
EP400	57634	broad.mit.edu	37	12	132496054	132496054	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:132496054C>T	ENST00000333577.4	+	17	3533	c.3424C>T	c.(3424-3426)Ccc>Tcc	p.P1142S	EP400_ENST00000332482.4_Missense_Mutation_p.P1069S|EP400_ENST00000389561.2_Missense_Mutation_p.P1106S|EP400_ENST00000330386.6_Missense_Mutation_p.P1106S|EP400_ENST00000389562.2_Missense_Mutation_p.P1105S			Q96L91	EP400_HUMAN	E1A binding protein p400	1142	Helicase ATP-binding.|Interactions with RUVBL1 and RUVBL2.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TAATTGGGGCCCCCATCTTGT	0.453000													19	33					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100568703	100568703	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:100568703C>T	ENST00000358544.2	+	31	4957	c.4846C>T	c.(4846-4848)Cga>Tga	p.R1616*	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Nonsense_Mutation_p.R1591*	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1616					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AGGAATTCTTCGAGATCCTGG	0.358000													11	20					0	0	1	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	104961395	104961395	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:104961395G>A	ENST00000372582.1	+	7	1564	c.808G>A	c.(808-810)Gga>Aga	p.G270R	IL1RAPL2_ENST00000344799.4_Missense_Mutation_p.G270R	NM_017416.1	NP_059112.1	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	270	Ig-like C2-type 3.				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(23)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						AGCATTCTTCGGATTCAGTGG	0.438000													57	8					0	0	1	0	0
PRPF4B	8899	broad.mit.edu	37	6	4041149	4041149	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:4041149C>T	ENST00000337659.6	+	4	1656	c.1556C>T	c.(1555-1557)tCg>tTg	p.S519L	PRPF4B_ENST00000538861.1_Missense_Mutation_p.S505L	NM_003913.4	NP_003904.3	Q13523	PRP4B_HUMAN	pre-mRNA processing factor 4B	519						catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(6)|endometrium(3)|large_intestine(5)|lung(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	22	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				CAGGAATCTTCGTCTGATGAT	0.358000													23	55					0	0	1	0	0
KRBA1	84626	broad.mit.edu	37	7	149430970	149430970	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:149430970C>T	ENST00000255992.10	+	18	3323	c.2924C>T	c.(2923-2925)cCt>cTt	p.P975L	KRBA1_ENST00000485033.2_Missense_Mutation_p.P915L|KRBA1_ENST00000319551.8_Missense_Mutation_p.P915L|KRBA1_ENST00000479560.1_3'UTR	NM_032534.2	NP_115923.2	A5PL33	KRBA1_HUMAN	KRAB-A domain containing 1	976	Pro-rich.									breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(17)|ovary(1)|prostate(1)	27	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGAGCCTCTCCTCCTGCAGCC	0.687000													3	11					0	0	1	0	0
FAM90A1	55138	broad.mit.edu	37	12	8374645	8374645	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:8374645G>A	ENST00000538603.1	-	7	1726	c.1168C>T	c.(1168-1170)Cag>Tag	p.Q390*	FAM90A1_ENST00000307435.6_Nonsense_Mutation_p.Q390*	NM_018088.3	NP_060558.3	Q86YD7	F90A1_HUMAN	family with sequence similarity 90, member A1	390							nucleic acid binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	25				Kidney(36;0.0866)		CTGAGAGGCTGGGCCCCATCA	0.647000													20	18					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3238337	3238337	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:3238337C>T	ENST00000217939.6	-	5	5543	c.5389G>A	c.(5389-5391)Gga>Aga	p.G1797R		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1797						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GAGGGTGATCCCGTGGTCTGC	0.493000													22	1					0	0	1	0	0
NUMA1	4926	broad.mit.edu	37	11	71717120	71717120	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:71717120G>A	ENST00000393695.3	-	22	5984	c.5653C>T	c.(5653-5655)Cgt>Tgt	p.R1885C	NUMA1_ENST00000358965.6_Missense_Mutation_p.R1871C|NUMA1_ENST00000351960.6_Missense_Mutation_p.R749C	NM_006185.2	NP_006176.2	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1885					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(12)|lung(20)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	65						TGGGAACGACGAGCAGAACTG	0.602000			T	RARA	APL								53	53					0	0	1	0	0
TAL1	6886	broad.mit.edu	37	1	47685498	47685498	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:47685498C>T	ENST00000371883.3	-	4	1472	c.896G>A	c.(895-897)gGg>gAg	p.G299E	TAL1_ENST00000459729.1_5'UTR|TAL1_ENST00000371884.2_Missense_Mutation_p.G297E|TAL1_ENST00000294339.3_Missense_Mutation_p.G297E			P17542	TAL1_HUMAN	T-cell acute lymphocytic leukemia 1	297					basophil differentiation|cell fate commitment|cell proliferation|embryonic hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|positive regulation of cell division|positive regulation of chromatin assembly or disassembly|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of protein complex assembly|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	E-box binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity			haematopoietic_and_lymphoid_tissue(1)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	15						GCTGGCTGCCCCATCCAGGGA	0.721000			T	"""TRD@, SIL"""	lymphoblastic leukemia/biphasic								77	27					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50532584	50532584	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:50532584C>T	ENST00000374144.3	+	3	2282	c.1994C>T	c.(1993-1995)aCc>aTc	p.T665I	C10orf71_ENST00000323868.4_Missense_Mutation_p.T665I			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	665										endometrium(1)	1						AAAATGAAGACCCACCAGCTA	0.527000													20	4					0	0	1	0	0
ZNF335	63925	broad.mit.edu	37	20	44590753	44590753	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:44590753G>A	ENST00000322927.2	-	10	1702	c.1602C>T	c.(1600-1602)taC>taT	p.Y534Y	ZNF335_ENST00000426788.1_Silent_p.Y379Y	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	534					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				CGTCCTTCCGGTAGACACTGG	0.622000													103	87					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129781471	129781471	+	Splice_Site	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:129781471T>C	ENST00000421865.2	+	49	7041		c.e49+2			NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2						cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CACTGTCAGGTTAGTTGAGAT	0.408000													35	27					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10360776	10360776	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:10360776G>A	ENST00000255381.2	-	16	1968	c.1858C>T	c.(1858-1860)Ctg>Ttg	p.L620L	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	620	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						AGGAAAGCCAGAGTCTTCATT	0.478000													36	14					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186536215	186536215	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:186536215G>A	ENST00000431808.1	-	17	3301	c.2738C>T	c.(2737-2739)cCg>cTg	p.P913L	SORBS2_ENST00000355634.5_Missense_Mutation_p.P1013L|SORBS2_ENST00000448662.2_Missense_Mutation_p.P474L|SORBS2_ENST00000284776.7_Missense_Mutation_p.P913L|SORBS2_ENST00000319471.9_Missense_Mutation_p.P544L|SORBS2_ENST00000418609.1_Missense_Mutation_p.P817L|SORBS2_ENST00000449407.2_Missense_Mutation_p.P457L|SORBS2_ENST00000498125.1_5'UTR|SORBS2_ENST00000393528.3_Missense_Mutation_p.P479L|SORBS2_ENST00000437304.2_Missense_Mutation_p.P637L			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	913	SH3 1.					actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		GTATGAGATCGGGAAGATGCC	0.443000													25	24					0	0	1	0	0
C19orf18	147685	broad.mit.edu	37	19	58485727	58485727	+	Missense_Mutation	SNP	G	G	A	rs150585544		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:58485727G>A	ENST00000314391.3	-	1	175	c.74C>T	c.(73-75)cCg>cTg	p.P25L		NM_152474.4	NP_689687.1	Q8NEA5	CS018_HUMAN	chromosome 19 open reading frame 18	25						integral to membrane				large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	8		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)		ATCTGCATACGGCAAGCATAA	0.398000													39	25					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53683083	53683083	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:53683083C>T	ENST00000257934.4	+	21	5009	c.4918C>T	c.(4918-4920)Ctc>Ttc	p.L1640F	ESPL1_ENST00000552462.1_Missense_Mutation_p.L1640F	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	1640					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						CCACAGACAGCTCAGGTGGGT	0.597000													21	56					0	0	1	0	0
RGS6	9628	broad.mit.edu	37	14	72818806	72818806	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:72818806G>A	ENST00000553530.1	+	3	295	c.88G>A	c.(88-90)Gaa>Aaa	p.E30K	RGS6_ENST00000406236.4_Missense_Mutation_p.E30K|RGS6_ENST00000556437.1_Missense_Mutation_p.E30K|RGS6_ENST00000402788.2_Missense_Mutation_p.E30K|RGS6_ENST00000555571.1_Missense_Mutation_p.E30K|RGS6_ENST00000355512.6_Missense_Mutation_p.E30K|RGS6_ENST00000553525.1_Missense_Mutation_p.E30K|RGS6_ENST00000343854.6_Missense_Mutation_p.E30K|RGS6_ENST00000404301.2_Missense_Mutation_p.E30K|RGS6_ENST00000407322.4_Missense_Mutation_p.E30K	NM_001204417.1|NM_001204418.1|NM_001204420.1|NM_001204421.1|NM_001204422.1|NM_004296.5	NP_001191346.1|NP_001191347.1|NP_001191349.1|NP_001191350.1|NP_001191351.1|NP_004287.3	P49758	RGS6_HUMAN	regulator of G-protein signaling 6	30					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		CTTTCAGATTGAAGACATCAT	0.378000													5	15					0	0	1	0	0
KIAA1429	25962	broad.mit.edu	37	8	95541354	95541354	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:95541354G>A	ENST00000297591.5	-	7	899	c.824C>T	c.(823-825)cCt>cTt	p.P275L	KIAA1429_ENST00000421249.2_Missense_Mutation_p.P275L|KIAA1429_ENST00000437199.1_Missense_Mutation_p.P275L	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	275	Glu-rich.				mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			ttcctcctcAGGAATACTGTC	0.438000													14	19					0	0	1	0	0
TBX20	57057	broad.mit.edu	37	7	35280490	35280490	+	Splice_Site	SNP	C	C	T	rs3999940		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:35280490C>T	ENST00000408931.3	-	5	1340		c.e5+1			NM_001077653.2|NM_001166220.1	NP_001071121.1|NP_001159692.1	Q9UMR3	TBX20_HUMAN	T-box 20							nucleus	DNA binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(9)|prostate(1)|skin(1)|stomach(1)	18						TGTACACTCACCAGTTGATTC	0.398000													8	30					0	0	1	0	0
CYP27A1	1593	broad.mit.edu	37	2	219679735	219679735	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:219679735C>T	ENST00000258415.4	+	9	2005	c.1578C>T	c.(1576-1578)ttC>ttT	p.F526F		NM_000784.3	NP_000775.1	Q02318	CP27A_HUMAN	cytochrome P450, family 27, subfamily A, polypeptide 1	526					bile acid biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|prostate(3)|urinary_tract(1)	26		Renal(207;0.0474)		Epithelial(149;9.48e-07)|all cancers(144;0.000171)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00981)	Cholecalciferol(DB00169)	GCCTGCAGTTCCTGCAGAGAC	0.587000													19	36					0	0	1	0	0
PRRC2A	7916	broad.mit.edu	37	6	31599163	31599163	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:31599163G>A	ENST00000376033.2	+	16	2947	c.2713G>A	c.(2713-2715)Gga>Aga	p.G905R	PRRC2A_ENST00000376007.4_Missense_Mutation_p.G905R	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	905	4 X 57 AA type A repeats.			PARGVGSGGQ -> LPASRSGA (in Ref. 1; AAA35585/AAA35586 and 8; CAA78744).		cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						GCCTGCCCGCGGAGTCGGGAG	0.657000													11	25					0	0	1	0	0
FAM13C	220965	broad.mit.edu	37	10	61029768	61029768	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:61029768C>T	ENST00000373867.3	-	8	910	c.445G>A	c.(445-447)Ggt>Agt	p.G149S	FAM13C_ENST00000442566.3_Missense_Mutation_p.G253S|FAM13C_ENST00000277705.6_Missense_Mutation_p.G253S|FAM13C_ENST00000468840.2_Missense_Mutation_p.G149S|FAM13C_ENST00000373868.2_Missense_Mutation_p.G232S|FAM13C_ENST00000435852.2_Missense_Mutation_p.G232S|FAM13C_ENST00000422313.2_Missense_Mutation_p.G232S|FAM13C_ENST00000419214.2_Missense_Mutation_p.G232S	NM_001166698.1	NP_001160170.1	Q8NE31	FA13C_HUMAN	family with sequence similarity 13, member C	232										NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						GGGTTATCACCATCAGTGATG	0.567000													27	7					0	0	1	0	0
AKR1CL1	340811	broad.mit.edu	37	10	5203822	5203822	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:5203822C>T	ENST00000334314.3	-	3	451	c.375G>A	c.(373-375)atG>atA	p.M125I						aldo-keto reductase family 1, member C-like 1											cervix(1)|endometrium(1)|large_intestine(2)|lung(2)	6						AGCTGACCTTCATAGCAAATG	0.413000													39	5					0	0	1	0	0
BICD2	23299	broad.mit.edu	37	9	95481454	95481454	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:95481454G>A	ENST00000356884.6	-	5	1540	c.1473C>T	c.(1471-1473)gcC>gcT	p.A491A	BICD2_ENST00000375512.3_Silent_p.A491A	NM_001003800.1	NP_001003800.1	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 (Drosophila)	491					microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			cervix(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23						CCTGGCGGCTGGCCTTCTCTA	0.682000													43	34					0	0	1	0	0
CPNE5	57699	broad.mit.edu	37	6	36724064	36724064	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:36724064C>T	ENST00000244751.2	-	13	1491	c.867G>A	c.(865-867)ccG>ccA	p.P289P	CPNE5_ENST00000393189.2_5'UTR|CPNE5_ENST00000459703.1_5'UTR	NM_020939.1	NP_065990.1	Q9HCH3	CPNE5_HUMAN	copine V	289										central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(4)|liver(1)|lung(9)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25						TTTTCTTTTTCGGGTTTACCA	0.522000													14	7					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9068743	9068743	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:9068743G>A	ENST00000397910.4	-	3	18906	c.18703C>T	c.(18703-18705)Cct>Tct	p.P6235S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6237	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAAGTTACAGGAGAAGGTGAG	0.483000													27	23					0	0	1	0	0
ZNF600	162966	broad.mit.edu	37	19	53270331	53270331	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:53270331G>A	ENST00000338230.3	-	3	945	c.678C>T	c.(676-678)tcC>tcT	p.S226S		NM_198457.2	NP_940859.2	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(9)|liver(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)		CCTGACTGAAGGACTTTCCAC	0.408000													53	64					0	0	1	0	0
CORO7	79585	broad.mit.edu	37	16	4411248	4411248	+	Splice_Site	SNP	A	A	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:4411248A>G	ENST00000251166.4	-	18	1834	c.1687_splice	c.e18-1	p.A563_splice	CORO7_ENST00000423908.2_3'UTR|CORO7_ENST00000537233.2_Splice_Site_p.A545_splice|CORO7_ENST00000574025.1_Splice_Site_p.A478_splice|CORO7_ENST00000539968.1_Splice_Site_p.A343_splice|CORO7-PAM16_ENST00000572467.1_Splice_Site_p.A563_splice	NM_024535.4	NP_078811.3			coronin 7											breast(3)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|prostate(2)|skin(2)|urinary_tract(2)	23						CGTCCTCACCAGCTGCAGAGG	0.657000													13	14					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	98187146	98187146	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:98187146G>A	ENST00000370192.3	-	5	503	c.403C>T	c.(403-405)Ctt>Ttt	p.L135F	DPYD_ENST00000306031.5_Missense_Mutation_p.L135F|DPYD_ENST00000423006.2_Missense_Mutation_p.L98F|DPYD_ENST00000474241.1_5'UTR	NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	135					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	CCTACACAAAGATCAGAGGTT	0.388000													83	27					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57745951	57745951	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr15:57745951G>A	ENST00000281282.5	+	7	2203	c.2125G>A	c.(2125-2127)Gaa>Aaa	p.E709K		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	709						myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		CCAGCTCTCAGAAATGCACGA	0.552000													17	2					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55989061	55989061	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:55989061G>A	ENST00000244728.5	-	15	2077	c.1680C>T	c.(1678-1680)ggC>ggT	p.G560G	COL21A1_ENST00000370819.1_Silent_p.G557G|COL21A1_ENST00000535941.1_Silent_p.G560G	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	560	Collagen-like 2.		G -> S (in dbSNP:rs9382581).		cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			GGCCAGGGAAGCCAGCATTCC	0.348000													4	4					0	0	1	0	0
SLC25A45	283130	broad.mit.edu	37	11	65147339	65147339	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:65147339G>A	ENST00000417511.2	-	7	1160	c.27_splice	c.e7+1	p.S9_splice	SLC25A45_ENST00000294187.6_Splice_Site_p.S9_splice|SLC25A45_ENST00000527174.1_Splice_Site_p.S51_splice|SLC25A45_ENST00000398802.1_Splice_Site_p.S51_splice|SLC25A45_ENST00000360662.3_Intron|SLC25A45_ENST00000526432.1_Splice_Site_p.S51_splice|SLC25A45_ENST00000534028.1_Intron|SLC25A45_ENST00000377152.2_Splice_Site_p.S9_splice	NM_001278251.1	NP_001265180.1	Q8N413	S2545_HUMAN	solute carrier family 25, member 45	51					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	14						GCCACTCACGGACTCATGGCG	0.612000													22	24					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41591588	41591588	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:41591588C>T	ENST00000396942.1	-	3	213		c.e3-1		ANK1_ENST00000352337.4_Splice_Site|ANK1_ENST00000379758.2_Splice_Site|ANK1_ENST00000289734.7_Splice_Site|ANK1_ENST00000265709.8_Splice_Site|ANK1_ENST00000396945.1_Splice_Site|ANK1_ENST00000347528.4_Splice_Site			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic						axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TCAACCCATTCTGTAAAGAGC	0.517000													47	66					0	0	1	0	0
NCK1	4690	broad.mit.edu	37	3	136664568	136664568	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:136664568G>T	ENST00000469404.1	+	2	269	c.178G>T	c.(178-180)Gaa>Taa	p.E60*	NCK1_ENST00000481752.1_Nonsense_Mutation_p.E124*|NCK1_ENST00000288986.2_Nonsense_Mutation_p.E124*	NM_001190796.1	NP_001177725.1	P16333	NCK1_HUMAN	NCK adaptor protein 1	124	SH3 1.				axon guidance|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of translation|signal complex assembly|T cell activation|T cell receptor signaling pathway	cytosol|endoplasmic reticulum|nucleus	cytoskeletal adaptor activity|receptor binding|receptor signaling complex scaffold activity			cervix(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	13						GAGAGAGGATGAATTATCATT	0.458000													38	28					8.16277e-20	8.29704e-20	1	1	0
FBN3	84467	broad.mit.edu	37	19	8160928	8160928	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:8160928C>T	ENST00000600128.1	-	45	5990	c.5576G>A	c.(5575-5577)gGg>gAg	p.G1859E	FBN3_ENST00000270509.2_Missense_Mutation_p.G1859E|FBN3_ENST00000601739.1_Missense_Mutation_p.G1859E			Q75N90	FBN3_HUMAN	fibrillin 3	1859	EGF-like 29; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						CTTGCAGGTCCCATTTCCACA	0.567000													32	24					0	0	1	0	0
HEG1	57493	broad.mit.edu	37	3	124746123	124746123	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:124746123G>A	ENST00000311127.4	-	3	906	c.839C>T	c.(838-840)tCc>tTc	p.S280F		NM_020733.1	NP_065784.1	Q9ULI3	HEG1_HUMAN	heart development protein with EGF-like domains 1	280						extracellular region|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(24)|ovary(2)|urinary_tract(4)	47						TGGTCCTGAGGAATTTCTCTT	0.532000													7	2					0	0	1	0	0
GPR65	8477	broad.mit.edu	37	14	88477394	88477394	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:88477394C>T	ENST00000267549.3	+	2	761	c.203C>T	c.(202-204)cCt>cTt	p.P68L	RP11-300J18.2_ENST00000554433.1_RNA	NM_003608.3	NP_003599.2	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	68					actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)	16						TTAACTCTCCCTTTATGGATT	0.393000													85	56					0	0	1	0	0
CRHR1	1394	broad.mit.edu	37	17	43911173	43911173	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:43911173G>A	ENST00000314537.5	+	11	1248	c.1023G>A	c.(1021-1023)cgG>cgA	p.R341R	CRHR1_ENST00000577353.1_Silent_p.R341R|CRHR1_ENST00000398285.3_Silent_p.R370R|CRHR1_ENST00000339069.5_Intron|CRHR1_ENST00000293493.7_Silent_p.R166R|CRHR1_ENST00000352855.5_Silent_p.R301R	NM_001145147.1|NM_001145148.1|NM_004382.4	NP_001138619.1|NP_001138620.1|NP_004373.2	P34998	CRFR1_HUMAN	corticotropin releasing hormone receptor 1	370					female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(15)|pancreas(1)|skin(1)	24	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)		AGGTCTCCCGGGTCGTCTTCA	0.582000													89	16					0	0	1	0	0
C14orf37	145407	broad.mit.edu	37	14	58605935	58605935	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:58605935C>T	ENST00000267485.7	-	2	336	c.142G>A	c.(142-144)Gat>Aat	p.D48N	C14orf37_ENST00000334342.5_5'UTR	NM_001001872.2	NP_001001872.2	Q86TY3	CN037_HUMAN	chromosome 14 open reading frame 37	48						integral to membrane	binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|skin(1)	33						TTCATCTTATCGGACTGCCCT	0.478000													43	141					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115428875	115428875	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:115428875G>A	ENST00000369522.3	+	14	1375	c.1135G>A	c.(1135-1137)Gaa>Aaa	p.E379K	SYCP1_ENST00000369518.1_Missense_Mutation_p.E379K	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	379					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGTGGTTACTGAATTTGAAAC	0.299000													6	91					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	14101558	14101558	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:14101558G>A	ENST00000310358.7	+	0	1202							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		ACACCCAAAGGATTACCCTCG	0.483000													12	25					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9578569	9578569	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:9578569C>T	ENST00000301480.4	-	10	1267	c.1054G>A	c.(1054-1056)Gaa>Aaa	p.E352K		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	352					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						TTTCCACATTCCTTACATTCA	0.373000													40	33					0	0	1	0	0
ACSF3	197322	broad.mit.edu	37	16	89180863	89180863	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:89180863C>T	ENST00000317447.4	+	6	1471	c.1094C>T	c.(1093-1095)tCc>tTc	p.S365F	CTD-2555A7.3_ENST00000562782.1_RNA|ACSF3_ENST00000378345.4_Missense_Mutation_p.S100F|ACSF3_ENST00000406948.3_Missense_Mutation_p.S365F	NM_001127214.2|NM_001243279.1|NM_174917.3	NP_001120686.1|NP_001230208.1|NP_777577.2	Q4G176	ACSF3_HUMAN	acyl-CoA synthetase family member 3	365					fatty acid metabolic process	mitochondrion	acid-thiol ligase activity|ATP binding			central_nervous_system(1)|endometrium(1)|kidney(2)|lung(9)|prostate(1)|urinary_tract(1)	15				BRCA - Breast invasive adenocarcinoma(80;0.0281)		ATGGCTCTGTCCGGGCCCCTG	0.647000													40	67					0	0	1	0	0
LGALS13	29124	broad.mit.edu	37	19	40095307	40095307	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:40095307C>T	ENST00000221797.4	+	2	126	c.81C>T	c.(79-81)atC>atT	p.I27I		NM_013268.2	NP_037400.1	Q9UHV8	PP13_HUMAN	lectin, galactoside-binding, soluble, 13	27	Galectin.				lipid catabolic process|phospholipid metabolic process		carboxylesterase activity|lysophospholipase activity|sugar binding			lung(5)|ovary(1)|urinary_tract(1)	7	all_cancers(60;1.77e-05)|all_lung(34;5.38e-08)|Lung NSC(34;6.37e-08)|Ovarian(47;0.116)		Epithelial(26;3.28e-26)|OV - Ovarian serous cystadenocarcinoma(5;7.31e-25)|all cancers(26;1.15e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			GGACACCAATCCACTCTTTTA	0.463000													37	34					0	0	1	0	0
TFEC	22797	broad.mit.edu	37	7	115596840	115596840	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:115596840C>T	ENST00000265440.7	-	4	455	c.275G>A	c.(274-276)gGa>gAa	p.G92E	TFEC_ENST00000320239.7_Missense_Mutation_p.G63E|TFEC_ENST00000484212.1_Missense_Mutation_p.G182E|TFEC_ENST00000457268.1_Missense_Mutation_p.G25E|TFEC_ENST00000393485.1_Missense_Mutation_p.G63E	NM_012252.3	NP_036384.1	O14948	TFEC_HUMAN	transcription factor EC	92	Necessary for transcriptional transactivation.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			NS(1)|kidney(1)|large_intestine(5)|lung(13)|prostate(2)|skin(1)|urinary_tract(2)	25			STAD - Stomach adenocarcinoma(10;0.00878)			CAAAATACTTCCAGATAACTT	0.318000													7	20					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32011626	32011626	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:32011626C>T	ENST00000375244.3	-	35	11631	c.11430G>A	c.(11428-11430)caG>caA	p.Q3810Q	TNXB_ENST00000375247.2_Silent_p.Q3808Q|TNXB_ENST00000451343.1_Silent_p.Q239Q			P22105	TENX_HUMAN	tenascin XB	3855	Fibronectin type-III 30.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CCTGGAGTTTCTGGGTCCGGG	0.637000													115	50					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121058703	121058703	+	Splice_Site	SNP	C	C	T	rs140608882	by1000genomes	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:121058703C>T	ENST00000392793.1	+	21	6433	c.6162_splice	c.e21+1	p.I2054_splice	TECTA_ENST00000264037.2_Splice_Site_p.I2054_splice			O75443	TECTA_HUMAN	tectorin alpha	2054	ZP.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CCTGTAAAATCGTAAGTGAGA	0.448000													19	36					0	0	1	0	0
PRR23C	389152	broad.mit.edu	37	3	138762974	138762974	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:138762974G>A	ENST00000413199.1	-	1	760	c.489C>T	c.(487-489)ttC>ttT	p.F163F	PRR23C_ENST00000502927.2_Silent_p.F163F|MRPS22_ENST00000495075.1_Intron	NM_001134657.1	NP_001128129.1	Q6ZRP0	PR23C_HUMAN	proline rich 23C	163										breast(2)|lung(7)|skin(2)	11						AGAGCTCCGGGAACTCAGAGT	0.657000													6	9					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112707633	112707633	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:112707633G>A	ENST00000550722.1	-	13	2159	c.1764C>T	c.(1762-1764)ttC>ttT	p.F588F	HECTD4_ENST00000430131.2_Silent_p.F300F|HECTD4_ENST00000377560.5_Silent_p.F550F	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		TTTGTGGGCTGAAGAAAAATT	0.378000													9	16					0	0	1	0	0
S1PR4	8698	broad.mit.edu	37	19	3179791	3179791	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:3179791C>T	ENST00000246115.3	+	1	1056	c.1001C>T	c.(1000-1002)cCc>cTc	p.P334L		NM_003775.3	NP_003766.1	O95977	S1PR4_HUMAN	sphingosine-1-phosphate receptor 4	334					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			breast(1)|kidney(2)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	13						ATGCGAGGGCCCGGGGACTGC	0.687000													25	87					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1339614	1339614	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:1339614C>T	ENST00000446702.2	+	7	1327	c.700C>T	c.(700-702)Cct>Tct	p.P234S	CNTN6_ENST00000350110.2_Missense_Mutation_p.P234S|CNTN6_ENST00000539053.1_Missense_Mutation_p.P162S			Q9UQ52	CNTN6_HUMAN	contactin 6	234	Ig-like C2-type 3.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		AGTGCGTTTTCCTGAAACTAT	0.358000													28	26					0	0	1	0	0
INTS7	25896	broad.mit.edu	37	1	212119995	212119995	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:212119995G>A	ENST00000366994.3	-	18	2473	c.2369C>T	c.(2368-2370)tCt>tTt	p.S790F	INTS7_ENST00000366993.3_Missense_Mutation_p.S776F|INTS7_ENST00000469606.1_5'UTR|INTS7_ENST00000440600.2_Missense_Mutation_p.S741F|INTS7_ENST00000366992.3_Intron	NM_001199811.1|NM_001199812.1|NM_015434.3	NP_001186740.1|NP_001186741.1|NP_056249.1	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	790					snRNA processing	integrator complex	protein binding			NS(1)|breast(1)|kidney(1)|large_intestine(8)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		TCTCTGGAAAGAAAGGGGAAC	0.348000													6	47					0	0	1	0	0
WISP1	8840	broad.mit.edu	37	8	134232832	134232832	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:134232832G>A	ENST00000250160.6	+	3	464	c.358G>A	c.(358-360)Ggt>Agt	p.G120S	WISP1_ENST00000517423.1_Intron|WISP1_ENST00000519433.1_Intron|WISP1_ENST00000220856.6_Intron|WISP1_ENST00000377863.2_Intron	NM_003882.3	NP_003873.1	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	120					cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	21	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			AGAGGTGGTCGGTGTGGGCTG	0.647000													30	46					0	0	1	0	0
OR8S1	341568	broad.mit.edu	37	12	48919555	48919555	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:48919555C>T	ENST00000310194.1	+	1	141	c.141C>T	c.(139-141)ctC>ctT	p.L47L	OR8S1_ENST00000551654.1_Intron	NM_001005203.2	NP_001005203.2	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S, member 1	47					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|skin(4)	22						TGCTGCTGCTCATGATCAGGG	0.498000													44	42					0	0	1	0	0
BUD13	84811	broad.mit.edu	37	11	116633303	116633303	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:116633303G>A	ENST00000260210.4	-	4	1025	c.1002C>T	c.(1000-1002)tcC>tcT	p.S334S	BUD13_ENST00000375445.3_Intron	NM_032725.3	NP_116114.1	Q9BRD0	BUD13_HUMAN	BUD13 homolog (S. cerevisiae)	334										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|pancreas(2)|skin(1)|urinary_tract(1)	22	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		CTCCAAAATGGGATTTTGCTT	0.448000													43	32					0	0	1	0	0
NAF1	92345	broad.mit.edu	37	4	164050305	164050305	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:164050305G>T	ENST00000274054.2	-	8	1422	c.1229C>A	c.(1228-1230)cCt>cAt	p.P410H	NAF1_ENST00000509434.1_Intron|NAF1_ENST00000422287.2_Intron	NM_138386.2	NP_612395.2	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 ribonucleoprotein	410					rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			NS(1)|autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(1)|lung(10)|ovary(2)	21	all_hematologic(180;0.166)	Prostate(90;0.109)				TCTCTGAGAAGGAAATCCTGA	0.483000													18	17					2.94398e-08	2.97218e-08	1	1	0
ABCC6	368	broad.mit.edu	37	16	16302617	16302617	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:16302617C>T	ENST00000205557.7	-	7	791	c.762G>A	c.(760-762)aaG>aaA	p.K254K	ABCC6_ENST00000574094.1_5'UTR	NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	254					response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		TCATCCACTCCTTTTCAAGCC	0.552000													34	41					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86394808	86394808	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:86394808C>T	ENST00000361669.2	+	2	1446	c.347C>T	c.(346-348)tCt>tTt	p.S116F	GRM3_ENST00000546348.1_Intron|GRM3_ENST00000439827.1_Missense_Mutation_p.S116F|GRM3_ENST00000394720.2_Missense_Mutation_p.S114F|GRM3_ENST00000536043.1_Intron	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	116					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GTCAGGGCATCTTTGACAAAA	0.443000													35	45					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179430689	179430689	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:179430689C>T	ENST00000589042.1	-	326	80394	c.80170G>A	c.(80170-80172)Gag>Aag	p.E26724K	TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E17659K|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E17851K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E17784K|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E25083K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E24156K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	25083	Ig-like 128.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGGTTGACTCACGTTTGTCA	0.418000													99	28					0	0	1	0	0
TRBV5-1	28614	broad.mit.edu	37	7	142021119	142021119	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:142021119G>A	ENST00000390381.3	+	0	408																											TGATCAAAACGAGAGGACAGC	0.537000													17	12					0	0	1	0	0
PSG8	440533	broad.mit.edu	37	19	43262328	43262328	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:43262328G>A	ENST00000404209.4	-	3	631	c.535C>T	c.(535-537)Ctg>Ttg	p.L179L	PSG8_ENST00000401467.2_Intron|PSG8_ENST00000600709.1_5'UTR|PSG8_ENST00000306511.4_Silent_p.L179L|PSG8_ENST00000406636.3_Silent_p.L57L	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	179	Ig-like C2-type 1.					extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				ATCCACCACAGGTAGCTTGCG	0.532000													109	191					0	0	1	0	0
C11orf88	399949	broad.mit.edu	37	11	111385544	111385544	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:111385544G>A	ENST00000529167.1	+	1	35	c.35G>A	c.(34-36)cGa>cAa	p.R12Q	RP11-794P6.6_ENST00000530283.1_RNA|C11orf88_ENST00000375618.4_Missense_Mutation_p.R12Q|C11orf88_ENST00000332814.6_Missense_Mutation_p.R12Q			Q6PI97	CK088_HUMAN	chromosome 11 open reading frame 88	12										endometrium(1)|large_intestine(3)|lung(2)	6						CCTAGCGGCCGAAAAGAGTCC	0.627000											OREG0021329	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	36					0	0	1	0	0
ELF5	2001	broad.mit.edu	37	11	34533109	34533109	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:34533109G>A	ENST00000312319.2	-	1	237	c.8C>T	c.(7-9)tCt>tTt	p.S3F	ELF5_ENST00000532417.1_Intron|ELF5_ENST00000257832.2_Intron|ELF5_ENST00000528709.1_5'UTR|ELF5_ENST00000429939.2_Intron	NM_001243081.1|NM_198381.1	NP_001230010.1|NP_938195.1	Q9UKW6	ELF5_HUMAN	E74-like factor 5 (ets domain transcription factor)	3					cell proliferation|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(4)|skin(1)	5		Acute lymphoblastic leukemia(5;0.0087)|all_hematologic(20;0.0384)				GTGAGGCAGAGATGGCATGGA	0.532000													14	14					0	0	1	0	0
IGFBP5	3488	broad.mit.edu	37	2	217543705	217543705	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:217543705G>A	ENST00000233813.4	-	2	1184	c.435C>T	c.(433-435)tcC>tcT	p.S145S		NM_000599.3	NP_000590.1	P24593	IBP5_HUMAN	insulin-like growth factor binding protein 5	145					negative regulation of insulin-like growth factor receptor signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|negative regulation of translation|signal transduction		insulin-like growth factor I binding			endometrium(1)|large_intestine(3)|lung(1)	5		Renal(323;0.0822)		Epithelial(149;2.1e-06)|all cancers(144;0.000165)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTTCAGCTCGGAGATGCGGG	0.602000													66	34					0	0	1	0	0
C3orf20	84077	broad.mit.edu	37	3	14814327	14814327	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:14814327C>T	ENST00000253697.3	+	17	3112	c.2660C>T	c.(2659-2661)cCt>cTt	p.P887L	C3orf20_ENST00000435614.1_Missense_Mutation_p.P765L|C3orf20_ENST00000412910.1_Missense_Mutation_p.P765L	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	887						cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						GAGCTACATCCTCTCAGCAGG	0.592000													5	15					0	0	1	0	0
GDF10	2662	broad.mit.edu	37	10	48438486	48438486	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:48438486G>A	ENST00000224605.2	-	1	490	c.225C>T	c.(223-225)gtC>gtT	p.V75V		NM_004962.3	NP_004953.1	P55107	BMP3B_HUMAN	growth differentiation factor 10	75					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(20)|skin(1)	31						TGTGGACAGCGACCATGTCCT	0.721000													7	1					0	0	1	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414855	14414855	+	RNA	SNP	A	A	G	rs141732548	by1000genomes	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr21:14414855A>G	ENST00000507941.1	+	0	95																											GCCAATGGCCATGCAGAAGTA	0.448000													4	31					0	0	1	0	0
C5orf20	140947	broad.mit.edu	37	5	134782503	134782503	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:134782503G>A	ENST00000503143.2	-	1	535	c.296C>T	c.(295-297)tCg>tTg	p.S99L	TIFAB_ENST00000537858.1_3'UTR	NM_130848.2	NP_570900.1	Q8TF63	DCNP1_HUMAN	chromosome 5 open reading frame 20	99						nucleus				endometrium(1)|lung(1)|prostate(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TGCTTCACTCGAAAGATTGGA	0.592000													31	12					0	0	1	0	0
HERC2P2	400322	broad.mit.edu	37	15	23300012	23300012	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr15:23300012G>A	ENST00000560464.1	-	0	4275																											GCTGCACCACGATCGGCAGAG	0.602000													10	1					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	14019049	14019049	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:14019049G>A	ENST00000279593.3	-	2	303	c.94C>T	c.(94-96)Ccc>Tcc	p.P32S		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	32					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATGCTGGGGGGGCTCTTCTGA	0.577000													12	38					0	0	1	0	0
SAG	6295	broad.mit.edu	37	2	234238222	234238222	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:234238222C>T	ENST00000409110.1	+	9	962	c.733_splice	c.e9+1	p.F244_splice	SAG_ENST00000449594.2_Splice_Site_p.F110_splice	NM_000541.4	NP_000532.2	P10523	ARRS_HUMAN	S-antigen; retina and pineal gland (arrestin)	244				F -> C (in Ref. 1; CAA30984).	rhodopsin mediated phototransduction|rhodopsin mediated signaling pathway		protein phosphatase inhibitor activity			cervix(1)|kidney(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	9		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.018)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.054)		Epithelial(121;2.86e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00608)|Lung(119;0.00714)|GBM - Glioblastoma multiforme(43;0.207)		TTAAAGCATTCGGTAGGACCT	0.468000													17	8					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89941887	89941887	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:89941887G>A	ENST00000405460.2	+	16	3097	c.3001G>A	c.(3001-3003)Gat>Aat	p.D1001N		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1001					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TAGAAGAAATGATGACCCCAT	0.343000													5	3					0	0	1	0	0
ARHGAP15	55843	broad.mit.edu	37	2	143959720	143959720	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:143959720G>A	ENST00000409869.1	+	4	360	c.183G>A	c.(181-183)agG>agA	p.R61R	ARHGAP15_ENST00000295095.6_Silent_p.R61R			Q53QZ3	RHG15_HUMAN	Rho GTPase activating protein 15	61					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			endometrium(1)|kidney(5)|large_intestine(8)|liver(2)|lung(15)|ovary(1)|skin(2)	34				BRCA - Breast invasive adenocarcinoma(221;0.151)		GACACAGAAGGAATCATTCAC	0.289000													11	55					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100645170	100645170	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:100645170C>T	ENST00000471714.1	-	2	365	c.256G>A	c.(256-258)Ggg>Agg	p.G86R	ABI3BP_ENST00000495063.1_Missense_Mutation_p.G86R|ABI3BP_ENST00000532144.1_5'UTR|ABI3BP_ENST00000284322.5_Missense_Mutation_p.G86R			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	86						extracellular space		p.G86R(2)		central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						GTGAATTTCCCTTCAGCGGGA	0.478000													12	24					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137622164	137622164	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:137622164G>A	ENST00000371817.3	+	7	1421	c.1007G>A	c.(1006-1008)gGg>gAg	p.G336E		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	336	Nonhelical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GTCGGCATCGGGGACTATGAC	0.622000													78	41					0	0	1	0	0
NPIPB4	440345	broad.mit.edu	37	16	21854860	21854860	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:21854860G>A	ENST00000415645.2	-	4	431	c.392C>T	c.(391-393)tCc>tTc	p.S131F	NPIPB4_ENST00000539318.1_5'UTR|NPIPB4_ENST00000357370.5_Missense_Mutation_p.S131F|NPIPB4_ENST00000451409.1_5'UTR					nuclear pore complex interacting protein family, member B4																		TCCTCGAAAGGAAGAAACTCT	0.428000													43	133					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108155142	108155142	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:108155142G>A	ENST00000278616.4	+	26	4320	c.3935G>A	c.(3934-3936)aGa>aAa	p.R1312K	ATM_ENST00000452508.2_Missense_Mutation_p.R1312K	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	1312					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.V1292_Q1331del(1)		NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GCACAGCAAAGAGAGACTGCT	0.373000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			19	15					0	0	1	0	0
MPHOSPH9	10198	broad.mit.edu	37	12	123641440	123641440	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:123641440G>A	ENST00000606320.1	-	24	3672	c.3466C>T	c.(3466-3468)Cgt>Tgt	p.R1156C	MPHOSPH9_ENST00000302349.5_Intron|MPHOSPH9_ENST00000541076.2_Missense_Mutation_p.R1126C|MPHOSPH9_ENST00000392425.3_Missense_Mutation_p.R1004C			Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	1004					M phase of mitotic cell cycle	centriole|Golgi membrane				NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(18)|prostate(2)|skin(1)	33	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		CTTTCCAAACGATCTTCCAAG	0.378000													12	18					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117199535	117199535	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:117199535G>A	ENST00000003084.6	+	11	1542	c.1410G>A	c.(1408-1410)gtG>gtA	p.V470V	CFTR_ENST00000454343.1_Silent_p.V409V	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	470	ABC transporter 1.		V -> M (in dbSNP:rs213950).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TTCTAATGGTGATTATGGGAG	0.393000									Cystic Fibrosis				18	36					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237893645	237893645	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:237893645G>A	ENST00000366574.2	+	77	11241	c.10924G>A	c.(10924-10926)Gaa>Aaa	p.E3642K	RYR2_ENST00000360064.6_Missense_Mutation_p.E3640K|RYR2_ENST00000542537.1_Missense_Mutation_p.E3626K	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3642					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TAAACTGATAGAAGATTTAGC	0.403000													27	5					0	0	1	0	0
TBXAS1	6916	broad.mit.edu	37	7	139661906	139661906	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:139661906C>T	ENST00000263552.6	+	13	1549	c.1011C>T	c.(1009-1011)ttC>ttT	p.F337F	TBXAS1_ENST00000448866.1_Silent_p.F336F|TBXAS1_ENST00000416849.2_Silent_p.F383F|TBXAS1_ENST00000462275.1_3'UTR|TBXAS1_ENST00000425687.1_Silent_p.F269F|TBXAS1_ENST00000414508.2_Silent_p.F337F|TBXAS1_ENST00000458722.1_Silent_p.F382F|TBXAS1_ENST00000436047.2_Silent_p.F337F|TBXAS1_ENST00000336425.5_Silent_p.F336F|TBXAS1_ENST00000411653.1_Silent_p.F336F	NM_001130966.2	NP_001124438.1	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	336					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					GCCAGGCCTTCATCTTCCTCA	0.542000													8	29					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26688924	26688924	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:26688924C>T	ENST00000529632.2	+	2	843	c.647C>T	c.(646-648)cCc>cTc	p.P216L	SEZ6L_ENST00000343706.4_Missense_Mutation_p.P216L|SEZ6L_ENST00000403121.1_5'UTR|SEZ6L_ENST00000248933.6_Missense_Mutation_p.P216L|SEZ6L_ENST00000360929.3_Missense_Mutation_p.P216L|SEZ6L_ENST00000404234.3_Missense_Mutation_p.P216L|SEZ6L_ENST00000402979.1_5'UTR	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	216						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						CACACACTCCCCCAGAGGCCA	0.647000													15	122					0	0	1	0	0
ZNF384	171017	broad.mit.edu	37	12	6787562	6787562	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:6787562G>A	ENST00000396795.1	-	5	914	c.417C>T	c.(415-417)acC>acT	p.T139T	ZNF384_ENST00000396799.2_Silent_p.T139T|ZNF384_ENST00000319770.3_Silent_p.T123T|ZNF384_ENST00000396801.3_Silent_p.T139T|ZNF384_ENST00000361959.3_Silent_p.T139T|ZNF384_ENST00000355772.4_Intron			Q8TF68	ZN384_HUMAN	zinc finger protein 384	139					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/ZNF384(4)	breast(3)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(1)	18						AAATGGGGAAGGTCTGAGCTG	0.547000			T	"""EWSR1, TAF15 """	ALL								7	10					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79051797	79051797	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr15:79051797G>A	ENST00000388820.4	-	24	5237	c.5027C>T	c.(5026-5028)cCc>cTc	p.P1676L		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1676					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						GCCTCGGGAGGGGGCGCCGTG	0.721000													10	3					0	0	1	0	0
RPL17-C18orf32	100526842	broad.mit.edu	37	18	47016828	47016828	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr18:47016828A>C	ENST00000584895.1	-	4	325	c.311T>G	c.(310-312)cTt>cGt	p.L104R	RPL17_ENST00000418495.1_Missense_Mutation_p.L104R|RPL17_ENST00000581373.1_Missense_Mutation_p.L66R|RPL17_ENST00000581091.1_5'UTR|RPL17_ENST00000580261.1_Missense_Mutation_p.L104R|RPL17_ENST00000579248.1_Missense_Mutation_p.L104R|RPL17-C18orf32_ENST00000332968.6_Missense_Mutation_p.L66R|MIR1539_ENST00000581232.1_RNA|RPL17_ENST00000579408.1_Missense_Mutation_p.L104R|RPL17_ENST00000580210.1_Missense_Mutation_p.L94R	NM_001199355.1|NM_001199356.1	NP_001186284.1|NP_001186285.1																					GGGTACCTTAAGTTCAGCATT	0.418000													32	39					0	0	1	0	0
PABPC1	26986	broad.mit.edu	37	8	101717162	101717162	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:101717162G>A	ENST00000318607.5	-	13	2938	c.1810C>T	c.(1810-1812)Cgt>Tgt	p.R604C	PABPC1_ENST00000522387.1_Missense_Mutation_p.R572C|PABPC1_ENST00000519004.1_Missense_Mutation_p.R559C	NM_002568.3	NP_002559.2	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	604	PABC.				mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity			breast(2)|endometrium(4)|kidney(15)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	40	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			ACCTTAGAACGGAGTGACTCT	0.393000													28	48					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10222145	10222145	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:10222145C>T	ENST00000418404.3	-	26	3863	c.3700G>A	c.(3700-3702)Gac>Aac	p.D1234N	MYH13_ENST00000570743.1_Missense_Mutation_p.D1234N|MYH13_ENST00000252172.4_Missense_Mutation_p.D1234N			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1234					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						CTGGCCATGTCGTCAATCTCC	0.577000													35	32					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28284008	28284008	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:28284008C>T	ENST00000305242.5	-	2	156	c.64G>A	c.(64-66)Gaa>Aaa	p.E22K		NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	22							binding	p.E22K(1)		NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						GGGGTGATTTCGAGGATTCCA	0.453000													5	32					0	0	1	0	0
PTH2R	5746	broad.mit.edu	37	2	209309521	209309521	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:209309521C>T	ENST00000272847.2	+	7	975	c.762C>T	c.(760-762)atC>atT	p.I254I	PTH2R_ENST00000413482.1_3'UTR	NM_005048.2	NP_005039.1	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor	254						integral to plasma membrane	parathyroid hormone receptor activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(21)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		ATTATTGGATCCTGGTGGAAG	0.393000													96	50					0	0	1	0	0
KCNJ14	3770	broad.mit.edu	37	19	48967557	48967557	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:48967557C>T	ENST00000391884.1	+	2	1310	c.834C>T	c.(832-834)atC>atT	p.I278I	KCNJ14_ENST00000342291.2_Silent_p.I278I			Q9UNX9	IRK14_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 14	278						voltage-gated potassium channel complex	inward rectifier potassium channel activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|skin(2)|urinary_tract(1)	10		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000109)|all cancers(93;0.000129)|Epithelial(262;0.0081)|GBM - Glioblastoma multiforme(486;0.0222)		TCCATGAGATCGACTCTGCCA	0.582000													15	16					0	0	1	0	0
ZMYM2	7750	broad.mit.edu	37	13	20625721	20625721	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:20625721C>T	ENST00000382869.3	+	13	2692	c.2441C>T	c.(2440-2442)cCt>cTt	p.P814L	ZMYM2_ENST00000382874.2_Missense_Mutation_p.P814L|ZMYM2_ENST00000382883.3_Missense_Mutation_p.P296L|ZMYM2_ENST00000382870.2_Missense_Mutation_p.P194L|ZMYM2_ENST00000382871.2_Missense_Mutation_p.P814L	NM_001190965.1|NM_003453.3|NM_197968.2	NP_001177894.1|NP_003444.1|NP_932072.1	Q9UBW7	ZMYM2_HUMAN	zinc finger, MYM-type 2	814					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	10		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		CAGAAAGGACCTGAAAACTTA	0.373000													14	14					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119750792	119750792	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:119750792G>A	ENST00000541757.1	+	17	1491	c.1111G>A	c.(1111-1113)Gac>Aac	p.D371N	MARCO_ENST00000327097.4_Missense_Mutation_p.D449N			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	449	Collagen-like.				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						AATTTGCGATGACGAGTGGCA	0.522000													31	157					0	0	1	0	0
DMKN	93099	broad.mit.edu	37	19	36002316	36002316	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:36002316G>A	ENST00000339686.3	-	5	1091	c.915C>T	c.(913-915)tcC>tcT	p.S305S	DMKN_ENST00000429837.1_Intron|DMKN_ENST00000447113.2_Silent_p.S305S|DMKN_ENST00000424570.2_Silent_p.S305S|DMKN_ENST00000419602.1_Intron|DMKN_ENST00000451297.2_Silent_p.S305S|DMKN_ENST00000418261.1_Silent_p.S305S|DMKN_ENST00000440396.1_Silent_p.S305S	NM_033317.4	NP_201574.3	Q6E0U4	DMKN_HUMAN	dermokine	305	Gly-rich.					extracellular region				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|ovary(1)|prostate(1)|skin(2)	27	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			AACTCACCCAGGAGGACTCAC	0.647000													8	27					0	0	1	0	0
CIDEA	1149	broad.mit.edu	37	18	12274179	12274179	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr18:12274179G>A	ENST00000320477.9	+	4	483	c.418G>A	c.(418-420)Gac>Aac	p.D140N	CIDEA_ENST00000521296.1_3'UTR	NM_001279.3	NP_001270.1	O60543	CIDEA_HUMAN	cell death-inducing DFFA-like effector a	140					DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change|lipid metabolic process|lipid storage|negative regulation of apoptosis|negative regulation of cytokine secretion|negative regulation of lipid catabolic process|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of sequestering of triglyceride|temperature homeostasis	mitochondrial envelope|nucleus	protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(6)|ovary(1)|pancreas(1)|prostate(2)	13						GAACCCCAAGGACTTCATCGG	0.582000													37	43					0	0	1	0	0
BCAR1	9564	broad.mit.edu	37	16	75276760	75276760	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:75276760T>C	ENST00000546196.1	-	2	1806	c.154A>G	c.(154-156)Acc>Gcc	p.T52A	BCAR1_ENST00000393420.6_Missense_Mutation_p.T81A|BCAR1_ENST00000393422.2_Missense_Mutation_p.T99A|BCAR1_ENST00000162330.5_Missense_Mutation_p.T81A|BCAR1_ENST00000542031.2_Missense_Mutation_p.T79A|BCAR1_ENST00000538440.2_Missense_Mutation_p.T81A|BCAR1_ENST00000420641.3_Missense_Mutation_p.T99A|BCAR1_ENST00000418647.3_Missense_Mutation_p.T127A|BCAR1_ENST00000535626.2_Intron			P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	81	SH3.				actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			breast(2)|central_nervous_system(5)|endometrium(1)|kidney(6)|large_intestine(1)|liver(1)|lung(13)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	35				BRCA - Breast invasive adenocarcinoma(221;0.169)		TGGGCCGGGGTGGCGGGAGGG	0.692000													4	44					0	0	1	0	0
BCL11B	64919	broad.mit.edu	37	14	99641003	99641003	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:99641003C>T	ENST00000345514.2	-	3	2223	c.1957G>A	c.(1957-1959)Gac>Aac	p.D653N	BCL11B_ENST00000443726.2_Missense_Mutation_p.D530N|BCL11B_ENST00000357195.3_Missense_Mutation_p.D724N	NM_022898.1	NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	724	Gly-rich.					nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		AGGAAGGGGTCCTTCATGAAG	0.692000			T	TLX3	T-ALL								5	23					0	0	1	0	0
DNAJB12	54788	broad.mit.edu	37	10	74103169	74103169	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:74103169G>A	ENST00000338820.3	-	3	663	c.514C>T	c.(514-516)Cac>Tac	p.H172Y	DNAJB12_ENST00000461919.1_5'UTR|DNAJB12_ENST00000394903.2_Missense_Mutation_p.H172Y|DNAJB12_ENST00000444643.2_Missense_Mutation_p.H138Y	NM_001002762.2	NP_001002762.2	Q9NXW2	DJB12_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 12	138	J.				protein folding	endoplasmic reticulum|integral to membrane	heat shock protein binding|unfolded protein binding			endometrium(1)|large_intestine(2)|skin(1)	4						TTGTCTGGGTGGAATTTGAGG	0.537000													16	5					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139158222	139158222	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:139158222G>A	ENST00000395297.1	-	15	3690	c.3520C>T	c.(3520-3522)Cta>Tta	p.L1174L		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1174										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TCAGACATTAGGAAGTCCAGT	0.438000										HNSCC(54;0.14)			25	52					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9087718	9087718	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:9087718C>T	ENST00000397910.4	-	1	4300	c.4097G>A	c.(4096-4098)gGa>gAa	p.G1366E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1366	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTTAGGACTTCCAGAGTAAGC	0.488000													12	49					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56184364	56184364	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr18:56184364G>A	ENST00000361673.3	-	9	5929	c.5716C>T	c.(5716-5718)Cat>Tat	p.H1906Y		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1906	Alpha-type protein kinase.						ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TAGCTGTCATGGAGGAAGTCT	0.527000													17	34					0	0	1	0	0
IMPG1	3617	broad.mit.edu	37	6	76640701	76640701	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:76640701C>T	ENST00000369950.3	-	15	2401	c.2212G>A	c.(2212-2214)Gag>Aag	p.E738K	IMPG1_ENST00000369963.3_3'UTR	NM_001563.2	NP_001554.2	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	738					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TGGAGGACCTCGCATTCCTTT	0.547000													19	65					0	0	1	0	0
KAT2B	8850	broad.mit.edu	37	3	20136892	20136892	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:20136892C>T	ENST00000263754.4	+	3	1023	c.568C>T	c.(568-570)Cta>Tta	p.L190L	KAT2B_ENST00000426228.1_3'UTR	NM_003884.4	NP_003875.3	Q92831	KAT2B_HUMAN	K(lysine) acetyltransferase 2B	190					cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	40						TTATTTCTATCTATTTAAGGT	0.368000													4	18					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4935290	4935290	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:4935290C>T	ENST00000345988.2	-	22	3455	c.3366G>A	c.(3364-3366)aaG>aaA	p.K1122K	PPL_ENST00000590782.2_Silent_p.K1120K	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	1122					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						TGGCCGCGTCCTTCTCCACCT	0.627000													33	34					0	0	1	0	0
VARS	7407	broad.mit.edu	37	6	31746952	31746952	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:31746952G>C	ENST00000375663.3	-	29	3958	c.3518C>G	c.(3517-3519)cCc>cGc	p.P1173R		NM_006295.2	NP_006286.1	P26640	SYVC_HUMAN	valyl-tRNA synthetase	1173					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	30					L-Valine(DB00161)	GCAACCCTGGGGGGCGGGAGC	0.706000													3	19					0	0	1	0	0
SLC6A2	6530	broad.mit.edu	37	16	55719064	55719064	+	Silent	SNP	C	C	T	rs146052293		TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:55719064C>T	ENST00000379906.2	+	4	909	c.654C>T	c.(652-654)gtC>gtT	p.V218V	SLC6A2_ENST00000568943.1_Silent_p.V218V|SLC6A2_ENST00000414754.3_Silent_p.V218V|SLC6A2_ENST00000219833.8_Silent_p.V218V|SLC6A2_ENST00000561820.1_Silent_p.V218V|SLC6A2_ENST00000567238.1_Silent_p.V113V|SLC6A2_ENST00000566163.1_Silent_p.V218V	NM_001043.3	NP_001034.1	P23975	SC6A2_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 2	218					synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(3)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	GGCGTGGTGTCCTGCACCTTC	0.592000													10	37					0	0	1	0	0
VPS37A	137492	broad.mit.edu	37	8	17132396	17132396	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:17132396C>T	ENST00000324849.4	+	5	1245	c.571C>T	c.(571-573)Cct>Tct	p.P191S	VPS37A_ENST00000521829.1_Missense_Mutation_p.P166S	NM_001145152.1|NM_152415.2	NP_001138624.1|NP_689628.2	Q8NEZ2	VP37A_HUMAN	vacuolar protein sorting 37 homolog A (S. cerevisiae)	191					cellular membrane organization|endosome transport|protein transport	centrosome|late endosome membrane|nucleus				autonomic_ganglia(1)|breast(1)|kidney(2)|large_intestine(1)|lung(4)|skin(1)	10				Colorectal(111;0.0553)|COAD - Colon adenocarcinoma(73;0.212)		CACAGCCAAGCCTGCCGCTCC	0.433000													12	61					0	0	1	0	0
ZNF177	7730	broad.mit.edu	37	19	9491817	9491817	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:9491817C>T	ENST00000434737.2	+	5	866	c.810C>T	c.(808-810)tcC>tcT	p.S270S	ZNF177_ENST00000343499.4_Intron|ZNF177_ENST00000590616.1_Intron|ZNF177_ENST00000541595.2_Intron|ZNF177_ENST00000446085.4_3'UTR|ZNF177_ENST00000602856.1_3'UTR|ZNF177_ENST00000602738.1_Intron|ZNF177_ENST00000589262.1_Silent_p.S270S			Q13360	ZN177_HUMAN	zinc finger protein 177	278					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|stomach(2)	13						ACCCTTTGTCCCTTCAGAACT	0.433000													21	28					0	0	1	0	0
ZNF582	147948	broad.mit.edu	37	19	56895279	56895279	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:56895279C>G	ENST00000301310.4	-	5	1665	c.1507G>C	c.(1507-1509)Gca>Cca	p.A503P	ZNF582_ENST00000586929.1_Missense_Mutation_p.A503P	NM_144690.1	NP_653291.1	Q96NG8	ZN582_HUMAN	zinc finger protein 582	503					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		TGGTTGCTTGCCAACATAAAT	0.383000													33	48					0	0	1	0	0
RQCD1	9125	broad.mit.edu	37	2	219447751	219447751	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:219447751A>T	ENST00000273064.6	+	3	637	c.262A>T	c.(262-264)Aac>Tac	p.N88Y	RQCD1_ENST00000295701.5_Missense_Mutation_p.N88Y|RQCD1_ENST00000542068.1_Missense_Mutation_p.N88Y|RQCD1_ENST00000509807.2_Missense_Mutation_p.N88Y	NM_005444.2	NP_005435.1	Q92600	RCD1_HUMAN	RCD1 required for cell differentiation1 homolog (S. pombe)	88					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|sex differentiation|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|prostate(3)|skin(1)	15		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000192)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACACCAGTCTAACAGAGTTTG	0.393000													60	30					0	0	1	0	0
TAAR2	9287	broad.mit.edu	37	6	132938786	132938786	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:132938786C>T	ENST00000275191.2	-	1	531	c.424G>A	c.(424-426)Gga>Aga	p.G142R	TAAR2_ENST00000367931.1_Missense_Mutation_p.G187R|TAAR2_ENST00000537809.1_Missense_Mutation_p.G142R	NM_014626.3	NP_055441.2	Q9P1P5	TAAR2_HUMAN	trace amine associated receptor 2	187						plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(1)	23	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00608)|GBM - Glioblastoma multiforme(226;0.0151)		CCCTCTATTCCATCTGCATAG	0.468000													26	19					0	0	1	0	0
OR1N2	138882	broad.mit.edu	37	9	125316096	125316096	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:125316096C>T	ENST00000373688.2	+	1	706	c.648C>T	c.(646-648)atC>atT	p.I216I		NM_001004457.1	NP_001004457.1	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N, member 2	216					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(3)	26						AGCTGATGATCATCACCATGG	0.502000													29	92					0	0	1	0	0
DIRAS3	9077	broad.mit.edu	37	1	68512858	68512858	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:68512858C>T	ENST00000370981.1	-	4	759	c.123G>A	c.(121-123)gtG>gtA	p.V41V	GNG12-AS1_ENST00000413628.1_RNA|GNG12-AS1_ENST00000420587.1_RNA|DIRAS3_ENST00000395201.1_Silent_p.V41V			O95661	DIRA3_HUMAN	DIRAS family, GTP-binding RAS-like 3	41					regulation of cyclin-dependent protein kinase activity|regulation of gene expression by genetic imprinting|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						TGCCGACTACCACGACGCGGT	0.582000													110	46					0	0	1	0	0
CYP4B1	1580	broad.mit.edu	37	1	47284396	47284396	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:47284396G>A	ENST00000271153.4	+	12	1482	c.1446G>A	c.(1444-1446)cgG>cgA	p.R482R	CYP4B1_ENST00000452782.2_Silent_p.R320R|CYP4B1_ENST00000371919.4_Silent_p.R468R|CYP4B1_ENST00000371923.4_Silent_p.R483R			P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B, polypeptide 1	482			R -> Q (in dbSNP:rs45622937).		xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	36	Acute lymphoblastic leukemia(166;0.155)					ACCCCTCACGGCTGCCCATCA	0.572000													78	89					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228506837	228506837	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:228506837C>T	ENST00000570156.2	+	65	17329	c.17255C>T	c.(17254-17256)aCt>aTt	p.T5752I	OBSCN_ENST00000366707.4_Missense_Mutation_p.T2429I|OBSCN_ENST00000366709.4_Missense_Mutation_p.T1914I|OBSCN_ENST00000284548.11_Missense_Mutation_p.T4795I|OBSCN_ENST00000422127.1_Missense_Mutation_p.T4795I	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	4795	DH.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CTGGCCCGCACTGGAGATGCT	0.652000													19	6					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32632916	32632916	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:32632916G>A	ENST00000242310.4	-	1	2751	c.2662C>T	c.(2662-2664)Cgt>Tgt	p.R888C		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	888					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding	p.R888C(1)		breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GTTGGTAAACGAAAATCAGAC	0.478000													24	68					0	0	1	0	0
KIF3C	3797	broad.mit.edu	37	2	26152311	26152311	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:26152311G>A	ENST00000264712.3	-	7	2730	c.2151C>T	c.(2149-2151)tcC>tcT	p.S717S	KIF3C_ENST00000496378.1_5'UTR|KIF3C_ENST00000405914.1_Silent_p.S717S	NM_002254.6	NP_002245.4	O14782	KIF3C_HUMAN	kinesin family member 3C	717	Globular (Potential).				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGCTGGAGGGGACACATCCA	0.507000													9	53					0	0	1	0	0
COL6A1	1291	broad.mit.edu	37	21	47423835	47423835	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr21:47423835G>T	ENST00000361866.3	+	35	3109	c.2995G>T	c.(2995-2997)Ggc>Tgc	p.G999C	COL6A1_ENST00000498614.1_3'UTR	NM_001848.2	NP_001839.2	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1	999	C-terminal globular domain.|VWFA 3.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	CGTGGCCTACGGCGAGAGCCA	0.662000													22	49					1.10513e-12	1.12014e-12	1	1	0
FBN3	84467	broad.mit.edu	37	19	8138086	8138086	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:8138086C>T	ENST00000600128.1	-	62	8212	c.7798G>A	c.(7798-7800)Gac>Aac	p.D2600N	FBN3_ENST00000270509.2_Missense_Mutation_p.D2600N|FBN3_ENST00000601739.1_Missense_Mutation_p.D2600N			Q75N90	FBN3_HUMAN	fibrillin 3	2600	EGF-like 43; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						TGATCAAAGTCAAAGCCAGAG	0.652000													15	53					0	0	1	0	0
DLK2	65989	broad.mit.edu	37	6	43418790	43418790	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr6:43418790C>T	ENST00000357338.3	-	6	1339	c.639G>A	c.(637-639)ctG>ctA	p.L213L	DLK2_ENST00000372485.1_Silent_p.L207L|DLK2_ENST00000414245.1_Silent_p.L207L|DLK2_ENST00000372488.3_Silent_p.L213L	NM_206539.1	NP_996262.1	Q6UY11	DLK2_HUMAN	delta-like 2 homolog (Drosophila)	213	EGF-like 6; calcium-binding (Potential).					integral to membrane	calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			CACAGTCATCCAGGTTGATGG	0.627000													54	24					0	0	1	0	0
COL18A1	80781	broad.mit.edu	37	21	46893894	46893894	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr21:46893894G>A	ENST00000359759.4	+	3	2003	c.1983_splice	c.e3+1	p.G661_splice	COL18A1_ENST00000400337.2_Splice_Site_p.G246_splice|COL18A1_ENST00000355480.5_Splice_Site_p.G426_splice			P39060	COIA1_HUMAN	collagen, type XVIII, alpha 1	661	Nonhelical region 1 (NC1).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		GACTCAGATGGGGTGAGTGAC	0.592000													6	3					0	0	1	0	0
DEPDC5	9681	broad.mit.edu	37	22	32234801	32234801	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:32234801C>T	ENST00000400246.1	+	27	2627	c.2485C>T	c.(2485-2487)Ccg>Tcg	p.P829S	DEPDC5_ENST00000266091.3_Missense_Mutation_p.P829S|DEPDC5_ENST00000400249.2_Missense_Mutation_p.P820S|DEPDC5_ENST00000382112.3_Missense_Mutation_p.P820S|DEPDC5_ENST00000535622.1_Missense_Mutation_p.P751S|DEPDC5_ENST00000382111.2_Missense_Mutation_p.P829S|DEPDC5_ENST00000400248.1_Missense_Mutation_p.P820S|DEPDC5_ENST00000382105.2_Missense_Mutation_p.P751S			O75140	DEPD5_HUMAN	DEP domain containing 5	820					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						TGTCCCGCCCCCGCTGAGCAG	0.473000													50	87					0	0	1	0	0
DLG2	1740	broad.mit.edu	37	11	83173111	83173111	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:83173111C>T	ENST00000398309.2	-	22	2910	c.2440G>A	c.(2440-2442)Gaa>Aaa	p.E814K	DLG2_ENST00000543673.1_Missense_Mutation_p.E919K|DLG2_ENST00000404783.3_Missense_Mutation_p.E292K|DLG2_ENST00000532653.1_Missense_Mutation_p.E796K|DLG2_ENST00000330014.6_Missense_Mutation_p.E735K|DLG2_ENST00000524982.1_Missense_Mutation_p.E810K|DLG2_ENST00000537455.1_Missense_Mutation_p.E564K|DLG2_ENST00000418306.2_Missense_Mutation_p.E693K|DLG2_ENST00000376104.2_Missense_Mutation_p.E919K|DLG2_ENST00000376106.3_Missense_Mutation_p.E278K|DLG2_ENST00000531015.1_Missense_Mutation_p.E781K|DLG2_ENST00000280241.8_Missense_Mutation_p.E853K|DLG2_ENST00000426717.2_Missense_Mutation_p.E278K	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	814	Guanylate kinase-like.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TTGGCTTGTTCCTCTGTTAGA	0.348000													13	36					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105414313	105414313	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:105414313G>A	ENST00000333244.5	-	7	7594	c.7475C>T	c.(7474-7476)tCa>tTa	p.S2492L	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2492						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CACCCCGAATGACGGCATCTT	0.607000													95	316					0	0	1	0	0
KIAA1429	25962	broad.mit.edu	37	8	95541355	95541355	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:95541355G>A	ENST00000297591.5	-	7	898	c.823C>T	c.(823-825)Cct>Tct	p.P275S	KIAA1429_ENST00000421249.2_Missense_Mutation_p.P275S|KIAA1429_ENST00000437199.1_Missense_Mutation_p.P275S	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	275	Glu-rich.				mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			tcctcctcAGGAATACTGTCT	0.433000													13	19					0	0	1	0	0
EVL	51466	broad.mit.edu	37	14	100595084	100595084	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:100595084G>A	ENST00000544450.2	+	6	1011	c.729_splice	c.e6+1	p.R243_splice	EVL_ENST00000402714.2_Splice_Site_p.R237_splice|EVL_ENST00000392920.3_Splice_Site_p.R239_splice			Q9UI08	EVL_HUMAN	Enah/Vasp-like	237	EVH2.				actin polymerization or depolymerization|axon guidance|cell surface receptor linked signaling pathway|organ morphogenesis	cytoskeleton|cytosol|focal adhesion|lamellipodium	actin binding|profilin binding|SH3 domain binding			cervix(1)|large_intestine(5)|lung(3)|ovary(3)|urinary_tract(2)	14		Melanoma(154;0.152)				AGAGTCCAACGGGTAAGAGCT	0.637000													8	24					0	0	1	0	0
LRFN4	78999	broad.mit.edu	37	11	66625721	66625721	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:66625721C>T	ENST00000309602.4	+	1	749	c.506C>T	c.(505-507)cCt>cTt	p.P169L	PC_ENST00000393960.1_Intron|PC_ENST00000393955.2_Intron|PC_ENST00000393958.2_Intron|LRFN4_ENST00000393952.3_Missense_Mutation_p.P169L	NM_024036.4	NP_076941.2	Q6PJG9	LRFN4_HUMAN	leucine rich repeat and fibronectin type III domain containing 4	169						integral to membrane				breast(1)|lung(1)|prostate(1)	3						GGCGCCATGCCTGCCCTGCAC	0.667000													34	23					0	0	1	0	0
GALNT11	63917	broad.mit.edu	37	7	151800385	151800385	+	Nonstop_Mutation	SNP	A	A	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:151800385A>T	ENST00000415421.1	+	5	963	c.608A>T	c.(607-609)tAa>tTa	p.*203L	GALNT11_ENST00000434507.1_Intron|GALNT11_ENST00000430044.2_Intron|GALNT11_ENST00000320311.2_Intron|GALNT11_ENST00000422997.2_Intron|GALNT11_ENST00000452146.2_Intron			Q8NCW6	GLT11_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)	0	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|prostate(5)|skin(2)	27	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.214)	OV - Ovarian serous cystadenocarcinoma(82;0.00168)	UCEC - Uterine corpus endometrioid carcinoma (81;0.177)|BRCA - Breast invasive adenocarcinoma(188;0.0932)		TGCACCTGGTAACATTGGATC	0.493000													8	6					0	0	1	0	0
PIK3CG	5294	broad.mit.edu	37	7	106508904	106508904	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:106508904G>A	ENST00000359195.3	+	2	1208	c.898G>A	c.(898-900)Gga>Aga	p.G300R	PIK3CG_ENST00000440650.2_Missense_Mutation_p.G300R|PIK3CG_ENST00000496166.1_Missense_Mutation_p.G300R	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	300					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						CCTCAAGAACGGAGAAGAGAT	0.587000													10	37					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79371428	79371428	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:79371428G>A	ENST00000264895.6	+	45	6838	c.6398G>A	c.(6397-6399)gGc>gAc	p.G2133D		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2132					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						ATGAAGCATGGCAACCTGGAG	0.493000													10	62					0	0	1	0	0
LIPN	643418	broad.mit.edu	37	10	90521241	90521241	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:90521241G>A	ENST00000404459.1	+	1	79	c.79G>A	c.(79-81)Gaa>Aaa	p.E27K		NM_001102469.1	NP_001095939.1	Q5VXI9	LIPN_HUMAN	lipase, family member N	27					lipid catabolic process	extracellular region	hydrolase activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(1)|skin(1)	9		Colorectal(252;0.0161)		Colorectal(12;4.83e-05)|COAD - Colon adenocarcinoma(12;6.5e-05)		TTTGGAAAATGAAGTGAATCC	0.383000													35	12					0	0	1	0	0
WASL	8976	broad.mit.edu	37	7	123332413	123332413	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:123332413G>A	ENST00000223023.4	-	9	1667	c.1335C>T	c.(1333-1335)atC>atT	p.I445I		NM_003941.2	NP_003932.3	O00401	WASL_HUMAN	Wiskott-Aldrich syndrome-like	445	WH2 2.				actin polymerization or depolymerization|axon guidance|cellular component movement|nitric oxide metabolic process|protein complex assembly|regulation of nitric-oxide synthase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|cytosol|nucleolus|plasma membrane	actin binding|small GTPase regulator activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						ATTTTAGTTGGATACCCTGTC	0.348000													14	34					0	0	1	0	0
PMEPA1	56937	broad.mit.edu	37	20	56228100	56228100	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:56228100C>T	ENST00000341744.3	-	3	626	c.307G>A	c.(307-309)Gga>Aga	p.G103R	PMEPA1_ENST00000347215.4_Missense_Mutation_p.G68R|PMEPA1_ENST00000395816.3_Missense_Mutation_p.G53R|PMEPA1_ENST00000395814.1_Missense_Mutation_p.G53R|PMEPA1_ENST00000265626.4_Missense_Mutation_p.G53R	NM_020182.4	NP_064567.2	Q969W9	PMEPA_HUMAN	prostate transmembrane protein, androgen induced 1	103					androgen receptor signaling pathway	integral to membrane|plasma membrane	WW domain binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)	16						TCTGGGATTCCGTTGCCTGAC	0.637000													5	8					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	148044308	148044308	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chrX:148044308C>T	ENST00000370460.2	+	13	3233	c.2754C>T	c.(2752-2754)tcC>tcT	p.S918S	AFF2_ENST00000370457.5_Silent_p.S885S|AFF2_ENST00000286437.5_Silent_p.S559S|AFF2_ENST00000342251.3_Silent_p.S885S	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	918					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					CTCCACTTTCCCCACTGCCAG	0.433000													17	3					0	0	1	0	0
LOC101929735	101929735	broad.mit.edu	37	14	22925659	22925659	+	RNA	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:22925659C>T	ENST00000514473.2	-	0	225																											CAAGGTTTTTCGTAATGATGC	0.453000													73	42					0	0	1	0	0
ROGDI	79641	broad.mit.edu	37	16	4851312	4851312	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:4851312C>T	ENST00000322048.7	-	4	589	c.211G>A	c.(211-213)Gtg>Atg	p.V71M	ROGDI_ENST00000586336.1_Intron	NM_024589.2	NP_078865.1	Q9GZN7	ROGDI_HUMAN	rogdi homolog (Drosophila)	71						intracellular				endometrium(2)|lung(1)|ovary(1)|skin(1)	5						ACACCCTTCACCTGGTCTGTG	0.687000													14	14					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3213790	3213790	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:3213790C>T	ENST00000355072.5	+	48	6694	c.6549C>T	c.(6547-6549)ctC>ctT	p.L2183L		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	2183					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		TGCAGCAGCTCCCTGCTGTCC	0.532000													23	22					0	0	1	0	0
FOXO1	2308	broad.mit.edu	37	13	41134688	41134688	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:41134688G>A	ENST00000379561.5	-	2	1324	c.940C>T	c.(940-942)Cgc>Tgc	p.R314C		NM_002015.3	NP_002006.2	Q12778	FOXO1_HUMAN	forkhead box O1	314					anti-apoptosis|blood vessel development|embryo development|endocrine pancreas development|insulin receptor signaling pathway|negative regulation of stress-activated MAPK cascade|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|response to DNA damage stimulus|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding		PAX7/FOXO1(197)|PAX3/FOXO1(749)	central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	20		Lung NSC(96;1.18e-05)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;7.32e-09)|Epithelial(112;2.87e-06)|OV - Ovarian serous cystadenocarcinoma(117;6.98e-05)|GBM - Glioblastoma multiforme(144;0.00394)|BRCA - Breast invasive adenocarcinoma(63;0.0815)		GTTCGAGGGCGAAATGTACTC	0.498000													21	48					0	0	1	0	0
HKDC1	80201	broad.mit.edu	37	10	71018672	71018672	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:71018672G>A	ENST00000354624.5	+	15	2306	c.2173G>A	c.(2173-2175)Gac>Aac	p.D725N	HKDC1_ENST00000395086.2_Missense_Mutation_p.D725N	NM_025130.3	NP_079406.3	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	725					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						GACCCGATACGACACGGAGGT	0.517000													8	2					0	0	1	0	0
ZBTB20	26137	broad.mit.edu	37	3	114069131	114069131	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:114069131G>A	ENST00000462705.1	-	11	2396	c.1575C>T	c.(1573-1575)ttC>ttT	p.F525F	ZBTB20_ENST00000474710.1_Silent_p.F598F|ZBTB20_ENST00000481632.1_Silent_p.F525F|ZBTB20_ENST00000393785.2_Silent_p.F525F|ZBTB20_ENST00000464560.1_Silent_p.F525F|ZBTB20_ENST00000471418.1_Silent_p.F525F|ZBTB20_ENST00000357258.3_Silent_p.F525F	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	598					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		CTGTGTGTACGAACATGTGCT	0.557000													48	45					0	0	1	0	0
CD300A	11314	broad.mit.edu	37	17	72473631	72473631	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:72473631C>T	ENST00000360141.3	+	4	878	c.590C>T	c.(589-591)tCc>tTc	p.S197F	CD300A_ENST00000361933.3_Intron|CD300A_ENST00000310828.5_Missense_Mutation_p.S84F|CD300A_ENST00000392625.3_Missense_Mutation_p.S84F|CD300A_ENST00000577511.1_Missense_Mutation_p.S67F	NM_001256841.1|NM_007261.3	NP_001243770.1|NP_009192.2	Q9UGN4	CLM8_HUMAN	CD300a molecule	197					cell adhesion	integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(4)|urinary_tract(1)	16						GTGGGGGCCTCCCTGCTAGCC	0.622000													10	31					0	0	1	0	0
C1QTNF9B	387911	broad.mit.edu	37	13	24465536	24465536	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:24465536C>T	ENST00000382137.3	-	3	962	c.894G>A	c.(892-894)ggG>ggA	p.G298G	C1QTNF9B-AS1_ENST00000382133.4_RNA|C1QTNF9B-AS1_ENST00000435039.2_RNA|C1QTNF9B_ENST00000382145.1_3'UTR|C1QTNF9B_ENST00000382140.2_Silent_p.G298G|C1QTNF9B_ENST00000556521.1_5'UTR	NM_001007537.1	NP_001007538.1	B2RNN3	C1T9B_HUMAN	C1q and tumor necrosis factor related protein 9B	298	C1q.					collagen				breast(1)|central_nervous_system(1)|large_intestine(3)|lung(1)	6						ACATCTCATCCCCGAGCTTCA	0.512000													24	38					0	0	1	0	0
SLC29A2	3177	broad.mit.edu	37	11	66131732	66131732	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:66131732C>T	ENST00000357440.2	-	11	1451	c.1223G>A	c.(1222-1224)gGc>gAc	p.G408D	RP11-867G23.8_ENST00000580881.1_Intron|SLC29A2_ENST00000546034.1_Missense_Mutation_p.G408D|SLC29A2_ENST00000544554.1_Missense_Mutation_p.G408D|SLC29A2_ENST00000311161.7_3'UTR	NM_001532.2	NP_001523.2	Q14542	S29A2_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 2	408					cell proliferation|nucleobase, nucleoside and nucleotide metabolic process	basolateral plasma membrane|integral to plasma membrane|nuclear membrane|nucleolus	nucleoside transmembrane transporter activity			breast(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	10						CACCAGGTAGCCATTAGAAAC	0.617000											OREG0021103	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	7					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1444001	1444001	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:1444001G>A	ENST00000446702.2	+	22	3444		c.e22-1		CNTN6_ENST00000350110.2_Splice_Site|CNTN6_ENST00000539053.1_Splice_Site			Q9UQ52	CNTN6_HUMAN	contactin 6						axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		ATTTTATTCAGATTCTGTACC	0.348000													8	23					0	0	1	0	0
TMC7	79905	broad.mit.edu	37	16	19049269	19049269	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:19049269C>T	ENST00000421369.3	+	8	1307	c.749C>T	c.(748-750)tCt>tTt	p.S250F	TMC7_ENST00000569532.1_Missense_Mutation_p.S360F|TMC7_ENST00000304381.5_Missense_Mutation_p.S360F|TMC7_ENST00000561963.1_3'UTR	NM_001160364.1	NP_001153836.1	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7	360						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	28						CGCATTTACTCTTTGAGACTG	0.393000													44	48					0	0	1	0	0
GALNS	2588	broad.mit.edu	37	16	88901703	88901703	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr16:88901703G>A	ENST00000268695.5	-	8	904	c.816C>T	c.(814-816)ctC>ctT	p.L272L	GALNS_ENST00000542788.1_Silent_p.L197L	NM_000512.4	NP_000503.1	P34059	GALNS_HUMAN	galactosamine (N-acetyl)-6-sulfate sulfatase	272						lysosome	metal ion binding|N-acetylgalactosamine-4-sulfatase activity|N-acetylgalactosamine-6-sulfatase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(8)	22				BRCA - Breast invasive adenocarcinoma(80;0.0496)	Hyaluronidase(DB00070)	GCAGGTCTTGGAGGAGCTCCA	0.577000													15	16					0	0	1	0	0
RPSAP52	204010	broad.mit.edu	37	12	66152165	66152165	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:66152165G>A	ENST00000489520.2	-	0	778					NR_026825.2																						GTCTCTTCAGGATCTCTGTAG	0.478000													7	6					0	0	1	0	0
ENOX1	55068	broad.mit.edu	37	13	43788201	43788201	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:43788201C>T	ENST00000261488.6	-	17	2434	c.1857G>A	c.(1855-1857)caG>caA	p.Q619Q	ENOX1_ENST00000412891.1_Silent_p.Q619Q	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	619					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		CCGTGAATTCCTGTTTGAACA	0.438000													17	44					0	0	1	0	0
ABCC5	10057	broad.mit.edu	37	3	183660662	183660662	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr3:183660662G>A	ENST00000334444.6	-	25	3787	c.3547C>T	c.(3547-3549)Ccc>Tcc	p.P1183S	ABCC5_ENST00000265586.6_Missense_Mutation_p.P1140S	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	1183						integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TCAGGGGAGGGAGCCTTGTTC	0.552000													12	41					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76503639	76503639	+	Silent	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr17:76503639G>A	ENST00000389840.5	-	28	4597	c.4473C>T	c.(4471-4473)acC>acT	p.T1491T	DNAH17_ENST00000585328.1_Silent_p.T1492T					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GGTGGCTCCAGGTTCGCTGGA	0.597000													19	6					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2224599	2224599	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr12:2224599G>A	ENST00000399655.1	+	2	524	c.259G>A	c.(259-261)Ggg>Agg	p.G87R	CACNA1C_ENST00000399591.1_Missense_Mutation_p.G87R|CACNA1C_ENST00000399603.1_Missense_Mutation_p.G87R|CACNA1C_ENST00000399634.1_Missense_Mutation_p.G87R|CACNA1C_ENST00000402845.3_Missense_Mutation_p.G87R|CACNA1C_ENST00000399629.1_Missense_Mutation_p.G87R|CACNA1C_ENST00000399597.1_Missense_Mutation_p.G87R|CACNA1C_ENST00000344100.3_Missense_Mutation_p.G87R|CACNA1C_ENST00000399595.1_Missense_Mutation_p.G87R|CACNA1C_ENST00000399637.1_Missense_Mutation_p.G87R|CACNA1C_ENST00000399621.1_Missense_Mutation_p.G87R|CACNA1C_ENST00000399644.1_Missense_Mutation_p.G87R|CACNA1C_ENST00000335762.5_Missense_Mutation_p.G87R|CACNA1C_ENST00000406454.3_Missense_Mutation_p.G87R|CACNA1C_ENST00000399617.1_Missense_Mutation_p.G87R|CACNA1C_ENST00000327702.7_Missense_Mutation_p.G87R|CACNA1C_ENST00000399601.1_Missense_Mutation_p.G87R|CACNA1C_ENST00000399638.1_Missense_Mutation_p.G87R|CACNA1C_ENST00000399641.1_Missense_Mutation_p.G87R|CACNA1C_ENST00000347598.4_Missense_Mutation_p.G87R|CACNA1C_ENST00000399649.1_Missense_Mutation_p.G87R|CACNA1C_ENST00000399606.1_Missense_Mutation_p.G87R|CACNA1C_ENST00000480911.1_Missense_Mutation_p.G87R	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	87					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity	p.G87W(3)|p.G117W(1)		NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GCAGCAATATGGGAAACCCAA	0.662000													13	27					0	0	1	0	0
RPS9	6203	broad.mit.edu	37	19	54710250	54710250	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:54710250C>T	ENST00000402367.1	+	4	442	c.327C>T	c.(325-327)cgC>cgT	p.R109R	RPS9_ENST00000391753.2_Silent_p.R109R|RPS9_ENST00000441429.1_Silent_p.R109R|RPS9_ENST00000302907.4_Silent_p.R109R|RPS9_ENST00000391751.3_Intron|RPS9_ENST00000391752.1_Silent_p.R109R			P46781	RS9_HUMAN	ribosomal protein S9	109	S4 RNA-binding.				endocrine pancreas development|positive regulation of cell proliferation|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding|rRNA binding|structural constituent of ribosome|translation regulator activity			NS(1)|breast(1)|kidney(11)|large_intestine(3)|lung(2)|ovary(1)|urinary_tract(1)	20	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.18)		TAGAGAGACGCCTGCAGACCC	0.602000													11	37					0	0	1	0	0
FAM124A	220108	broad.mit.edu	37	13	51826269	51826269	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:51826269C>T	ENST00000322475.8	+	3	901	c.766C>T	c.(766-768)Cct>Tct	p.P256S	FAM124A_ENST00000280057.6_Missense_Mutation_p.P292S	NM_001242312.1	NP_001229241.1	Q86V42	F124A_HUMAN	family with sequence similarity 124A	256										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|skin(1)	26		Acute lymphoblastic leukemia(7;0.000334)|Breast(56;0.00156)|Prostate(109;0.00538)|Lung NSC(96;0.0216)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;4.25e-07)		CCTGCCCAACCCTTGCAGCCC	0.627000													20	32					0	0	1	0	0
ZNF90	7643	broad.mit.edu	37	19	20229954	20229954	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:20229954C>T	ENST00000418063.2	+	4	1703	c.1591C>T	c.(1591-1593)Cat>Tat	p.H531Y	ZNF90_ENST00000474284.1_Intron	NM_007138.1	NP_009069.1	Q03938	ZNF90_HUMAN	zinc finger protein 90	531						Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|lung(2)|ovary(1)|skin(1)	5						TAAGATAATTCATACTGGAGC	0.413000													13	15					0	0	1	0	0
PPP2R2C	5522	broad.mit.edu	37	4	6349713	6349713	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:6349713T>C	ENST00000335585.5	-	6	673	c.650A>G	c.(649-651)aAc>aGc	p.N217S	PPP2R2C_ENST00000506140.1_Missense_Mutation_p.N210S|PPP2R2C_ENST00000515571.1_Missense_Mutation_p.N200S|PPP2R2C_ENST00000507294.1_Missense_Mutation_p.N210S|PPP2R2C_ENST00000382599.4_Missense_Mutation_p.N217S|PPP2R2C_ENST00000314348.8_5'UTR	NM_181876.2	NP_870991.1	Q9Y2T4	2ABG_HUMAN	protein phosphatase 2, regulatory subunit B, gamma	217					signal transduction	protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	28						GTCCTCCATGTTGGCCGGCTT	0.612000													22	22					0	0	1	0	0
NPY5R	4889	broad.mit.edu	37	4	164271506	164271506	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr4:164271506C>T	ENST00000515560.1	+	4	1603	c.81C>T	c.(79-81)ttC>ttT	p.F27F	NPY5R_ENST00000506953.1_Silent_p.F27F|NPY5R_ENST00000338566.3_Silent_p.F27F			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	27					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane		p.F27F(1)		NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				ATTCTGATTTCCCAGTCTGGG	0.393000													22	22					0	0	1	0	0
SIAH3	283514	broad.mit.edu	37	13	46357545	46357545	+	Silent	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:46357545C>T	ENST00000400405.2	-	2	889	c.783G>A	c.(781-783)gaG>gaA	p.E261E		NM_198849.2	NP_942146.2	Q8IW03	SIAH3_HUMAN	siah E3 ubiquitin protein ligase family member 3	261					multicellular organismal development|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding			large_intestine(3)|lung(7)|ovary(1)|skin(1)	12						AGGGGAGGACCTCTGTCGCGG	0.602000													59	48					0	0	1	0	0
C10orf12	26148	broad.mit.edu	37	10	98743333	98743333	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:98743333C>T	ENST00000286067.2	+	1	2293	c.2186C>T	c.(2185-2187)tCa>tTa	p.S729L		NM_015652.2	NP_056467.2	Q8N655	CJ012_HUMAN	chromosome 10 open reading frame 12	729										NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(3)|prostate(2)|skin(2)|stomach(4)	45		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		TTGACCTCTTCAACCTACAAC	0.488000													31	5					0	0	1	0	0
MCOLN1	57192	broad.mit.edu	37	19	7593125	7593125	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:7593125C>T	ENST00000264079.6	+	7	984	c.859C>T	c.(859-861)Ccc>Tcc	p.P287S		NM_020533.2	NP_065394.1	Q9GZU1	MCLN1_HUMAN	mucolipin 1	287					calcium ion transport|cellular iron ion homeostasis|transferrin transport	integral to plasma membrane|late endosome membrane|lysosomal membrane	cation channel activity|iron ion transmembrane transporter activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GTGTAAGCACCCCAGTGTCTT	0.642000													18	26					0	0	1	0	0
ARPC2	10109	broad.mit.edu	37	2	219103464	219103464	+	Silent	SNP	T	T	C			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:219103464T>C	ENST00000295685.10	+	5	607	c.346T>C	c.(346-348)Ttg>Ctg	p.L116L	ARPC2_ENST00000477992.1_3'UTR|ARPC2_ENST00000315717.5_Silent_p.L116L	NM_005731.2	NP_005722.1	O15144	ARPC2_HUMAN	actin related protein 2/3 complex, subunit 2, 34kDa	116					cellular component movement	Arp2/3 protein complex|cell projection|Golgi apparatus	actin binding|structural constituent of cytoskeleton			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)	6		Renal(207;0.0474)		Epithelial(149;1.21e-06)|all cancers(144;0.000212)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0103)		AGCTGGCATGTTGAAGCGAAA	0.413000													88	35					0	0	1	0	0
MOV10L1	54456	broad.mit.edu	37	22	50547128	50547128	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:50547128G>A	ENST00000262794.5	+	5	681	c.598G>A	c.(598-600)Gaa>Aaa	p.E200K	MOV10L1_ENST00000395858.3_Missense_Mutation_p.E200K|MOV10L1_ENST00000545383.1_Missense_Mutation_p.E200K|MOV10L1_ENST00000540615.1_Missense_Mutation_p.E180K|MOV10L1_ENST00000395843.1_5'UTR	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	200					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding	p.E200*(1)		breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		GGTGTTAGAGGAAAGCATCTT	0.567000													17	39					0	0	1	0	0
MIR382	494331	broad.mit.edu	37	14	101520688	101520688	+	RNA	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:101520688G>A	ENST00000385009.2	-	0	35					NR_029874.1																						TACTTATGACGAATCATTCAC	0.448000													11	16					0	0	1	0	0
TUB	7275	broad.mit.edu	37	11	8060512	8060512	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:8060512G>A	ENST00000305253.4	+	1	333	c.92G>A	c.(91-93)gGa>gAa	p.G31E	RP11-236J17.6_ENST00000526646.1_RNA|RP11-236J17.6_ENST00000528151.1_RNA|TUB_ENST00000534099.1_Intron	NM_003320.4	NP_003311.2	P50607	TUB_HUMAN	tubby bipartite transcription factor	0					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				breast(1)|cervix(1)|endometrium(9)|large_intestine(7)|lung(5)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	26		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		TGGCCCATGGGATCTCAGCAT	0.572000													19	30					0	0	1	0	0
ZNF284	342909	broad.mit.edu	37	19	44590530	44590530	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:44590530C>T	ENST00000421176.3	+	5	1115	c.899C>T	c.(898-900)tCa>tTa	p.S300L	ZNF223_ENST00000591793.1_3'UTR	NM_001037813.2	NP_001032902.1	Q2VY69	ZN284_HUMAN	zinc finger protein 284	300					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|kidney(2)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	15		Prostate(69;0.0435)				CATAGTAGATCAAATCTTAAT	0.388000													25	35					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42694688	42694688	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr20:42694688C>A	ENST00000358131.5	+	6	1451	c.1243C>A	c.(1243-1245)Ccc>Acc	p.P415T	TOX2_ENST00000372999.1_Missense_Mutation_p.P391T|TOX2_ENST00000423191.1_Missense_Mutation_p.P391T|TOX2_ENST00000435864.2_Missense_Mutation_p.P311T|TOX2_ENST00000341197.3_Missense_Mutation_p.P433T	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	415	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CCCTGTCCTGCCCACCCCCAT	0.672000													5	24					0.184627	0.184834	1	1	0
COL4A2	1284	broad.mit.edu	37	13	111088644	111088644	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr13:111088644G>A	ENST00000360467.5	+	13	1061	c.755G>A	c.(754-756)gGg>gAg	p.G252E		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	252	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GGACCCAACGGGATTCCATCA	0.463000													15	19					0	0	1	0	0
RP11-435B5.5	0	broad.mit.edu	37	1	143391935	143391936	+	RNA	INS	-	-	TG			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:143391935_143391936insTG	ENST00000428624.1	+	0	2065				RP11-435B5.4_ENST00000423249.1_lincRNA																							ATATATATATATAAAGAGATTG	0.252													3	5	---	---	---	---					
ARV1	64801	broad.mit.edu	37	1	231131567	231131567	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr1:231131567delA	ENST00000310256.2	+	4	567	c.510delA	c.(508-510)gcfs	p.A170fs	ARV1_ENST00000366658.2_Frame_Shift_Del_p.A130fs|ARV1_ENST00000497753.1_3'UTR	NM_022786.1	NP_073623.1	Q9H2C2	ARV1_HUMAN	ARV1 homolog (S. cerevisiae)	170					sphingolipid metabolic process	integral to membrane				breast(3)|large_intestine(2)|lung(2)	7	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)		COAD - Colon adenocarcinoma(196;0.211)|Colorectal(1306;0.233)		CCATGACGGCAAAAAAAAAGC	0.383													9	82	---	---	---	---					
NBEAL1	65065	broad.mit.edu	37	2	204073989	204073989	+	Frame_Shift_Del	DEL	T	T	-			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr2:204073989delT	ENST00000449802.1	+	52	7975	c.7642delT	c.(7642-7644)ctfs	p.S2548fs		NM_001114132.1	NP_001107604.1	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1	2548							binding			NS(1)|breast(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						TTTGGCTATATCTTGGGAAGG	0.418													67	27	---	---	---	---					
FCHO2	115548	broad.mit.edu	37	5	72348292	72348292	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr5:72348292delA	ENST00000430046.2	+	13	1247	c.1131delA	c.(1129-1131)ttfs	p.L377fs	FCHO2_ENST00000341845.6_Frame_Shift_Del_p.L377fs|FCHO2_ENST00000512348.1_Frame_Shift_Del_p.L344fs	NM_001146032.1|NM_138782.2	NP_001139504.1|NP_620137.2	Q0JRZ9	FCHO2_HUMAN	FCH domain only 2	377										cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(1)	17		Lung NSC(167;0.0465)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;4.6e-53)		TGGATGAATTAAAAGTATCTA	0.338													2	4	---	---	---	---					
PCLO	27445	broad.mit.edu	37	7	82595413	82595413	+	Frame_Shift_Del	DEL	C	C	-			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr7:82595413delC	ENST00000423517.2	-	4	4028	c.3691delG	c.(3691-3693)aafs	p.E1231fs	PCLO_ENST00000333891.8_Frame_Shift_Del_p.E1231fs	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1170					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GGCTTTTTTTCTTCAGAACGT	0.393													8	174	---	---	---	---					
MROH5	389690	broad.mit.edu	37	8	142459777	142459778	+	RNA	INS	-	-	A	rs144781370	by1000genomes	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr8:142459777_142459778insA	ENST00000430863.1	-	0	2629_2630					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		GCAGACAGGCCAGCAGTGTGGT	0.678													5	2	---	---	---	---					
BAAT	570	broad.mit.edu	37	9	104133226	104133227	+	In_Frame_Ins	INS	-	-	GGAGAA			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr9:104133226_104133227insGGAGAA	ENST00000259407.2	-	2	568_569	c.460_461insTTCTCC	c.(460-462)tcc>TTCTCCtcc	p.153_154insFS	BAAT_ENST00000395051.3_In_Frame_Ins_p.153_154insFS	NM_001127610.1|NM_001701.3	NP_001121082.1|NP_001692.1	Q14032	BAAT_HUMAN	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	153					acyl-CoA metabolic process|bile acid and bile salt transport|bile acid biosynthetic process|digestion|fatty acid metabolic process|glycine metabolic process	cytosol|peroxisomal matrix	carboxylesterase activity|glycine N-choloyltransferase activity|N-acyltransferase activity|palmitoyl-CoA hydrolase activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		Acute lymphoblastic leukemia(62;0.0559)			Glycine(DB00145)	CTCACCTGGAGGGAGAAAGAGA	0.436													17	41	---	---	---	---					
UPF2	26019	broad.mit.edu	37	10	12046612	12046614	+	In_Frame_Del	DEL	AAA	AAA	-			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:12046612_12046614delAAA	ENST00000356352.2	-	4	1892_1894	c.1419_1421delTTT	c.(1417-1422)gag>ga	p.DL473del	UPF2_ENST00000357604.5_In_Frame_Del_p.DL473del|UPF2_ENST00000397053.2_In_Frame_Del_p.DL473del			Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog (yeast)	473					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(14)|lung(17)|ovary(2)|skin(3)|urinary_tract(2)	56		Renal(717;0.228)				AAAAGCCTTCAAATCAATGAGGT	0.355													26	8	---	---	---	---					
LOC399815	399815	broad.mit.edu	37	10	124654324	124654325	+	RNA	INS	-	-	GTTACTAGTTTGTAACTACACTTTTTTTTTTCAA	rs144762615	by1000genomes	TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr10:124654324_124654325insGTTACTAGTTTGTAACTACACTTTTTTTTTTCAA	ENST00000425266.1	+	0	291																											TCTCCCTTCTTGTTACTAGTTT	0.386													5	6	---	---	---	---					
CCDC88B	283234	broad.mit.edu	37	11	64112135	64112136	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr11:64112135_64112136insT	ENST00000356786.5	+	14	2166_2167	c.2122_2123insT	c.(2122-2124)ccafs	p.P708fs	CCDC88B_ENST00000463837.1_3'UTR|CCDC88B_ENST00000301897.4_5'UTR	NM_032251.5	NP_115627.6	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B	708					microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GGCTCTTGAGGTCCAGGTCTGG	0.624													10	20	---	---	---	---					
OTX2-AS1	100309464	broad.mit.edu	37	14	57509058	57509064	+	RNA	DEL	TCCAAGC	TCCAAGC	-			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr14:57509058_57509064delTCCAAGC	ENST00000554725.1	+	0	344																											CCAGAAGCCTTCCAAGCTCCAAGCCCT	0.483													4	8	---	---	---	---					
SBNO2	22904	broad.mit.edu	37	19	1110855	1110855	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:1110855delG	ENST00000361757.3	-	26	3154	c.2917delC	c.(2917-2919)tgfs	p.L973fs	SBNO2_ENST00000438103.2_Frame_Shift_Del_p.L916fs|SBNO2_ENST00000587024.1_Frame_Shift_Del_p.L963fs	NM_014963.2	NP_055778.2	Q9Y2G9	SBNO2_HUMAN	strawberry notch homolog 2 (Drosophila)	973					macrophage activation involved in immune response|negative regulation of transcription, DNA-dependent|regulation of inflammatory response|transcription, DNA-dependent					NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCAGCCCCAGGATGCGGTTC	0.587													20	48	---	---	---	---					
PLIN4	729359	broad.mit.edu	37	19	4517676	4517676	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:4517676delA	ENST00000301286.3	-	1	40	c.41delT	c.(40-42)tcfs	p.F14fs		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4	14						lipid particle|plasma membrane				NS(2)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|soft_tissue(1)|stomach(2)	41						GGCAGAGCTGAAGCCAGGCAG	0.692													2	4	---	---	---	---					
GAPDHS	26330	broad.mit.edu	37	19	36029298	36029309	+	Splice_Site	DEL	AATACATGGTCA	AATACATGGTCA	-			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr19:36029298_36029309delAATACATGGTCA	ENST00000222286.4	+	3	451_458	c.342_splice	c.e3+1	p.112_splice		NM_014364.4	NP_055179.1	O14556	G3PT_HUMAN	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	112					gluconeogenesis|glycolysis|positive regulation of glycolysis|sperm motility	cytosol	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(8)	11	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		NADH(DB00157)	ATTGACCCGGAATACATGGTCAGTAGCTGGCA	0.571													7	13	---	---	---	---					
IGLV7-46	28775	broad.mit.edu	37	22	22724183	22724183	+	RNA	DEL	C	C	-			TCGA-D3-A51G-06A-11D-A25O-08	TCGA-D3-A51G-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5CD2F5CF-8947-42BD-AA32-0A7E50E4DD1B	5B34AC89-1869-4837-BB7F-77495A9411A2	g.chr22:22724183delC	ENST00000390295.2	+	0	113																											GACTCAGGAGCCCTCACTGAC	0.507													16	26	---	---	---	---