Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NBPF14	25832	broad.mit.edu	37	1	148012531	148012531	+	Silent	SNP	C	C	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr1:148012531C>T	ENST00000369219.1	-	12	1444	c.1428G>A	c.(1426-1428)aaG>aaA	p.K476K				Q5TI25	NBPFE_HUMAN	neuroblastoma breakpoint family, member 14	476	NBPF 5.					cytoplasm		p.K476K(2)|p.K476N(1)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(23)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	42	all_hematologic(923;0.032)					AGCCAACATGCTTTTCCTCCA	0.443000													4	8					0	0	2.56e-06	0	0
DOCK11	139818	broad.mit.edu	37	X	117752567	117752567	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chrX:117752567T>C	ENST00000276204.6	+	31	3421	c.3347T>C	c.(3346-3348)gTt>gCt	p.V1116A	DOCK11_ENST00000276202.7_Missense_Mutation_p.V1116A			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1116					blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						CACTTCTTGGTTGGTCTACTT	0.318000													28	52					0	0	3.70037e-05	0	0
RSRC2	65117	broad.mit.edu	37	12	123001841	123001841	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr12:123001841G>A	ENST00000331738.7	-	5	680	c.535C>T	c.(535-537)Cgt>Tgt	p.R179C	RSRC2_ENST00000354654.2_Missense_Mutation_p.R131C	NM_023012.5	NP_075388.2	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2	179	Ser-rich.									breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|urinary_tract(2)	24	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		GAGCGGGAACGAGACCTGATC	0.483000													39	27					0	0	2.05139e-05	0	0
FRG1B	284802	broad.mit.edu	37	20	29628261	29628261	+	Missense_Mutation	SNP	T	T	C	rs111331725	by1000genomes	TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr20:29628261T>C	ENST00000278882.3	+	6	643	c.263T>C	c.(262-264)tTt>tCt	p.F88S	FRG1B_ENST00000358464.4_Missense_Mutation_p.F88S|FRG1B_ENST00000439954.2_Missense_Mutation_p.F93S																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AATAGCTGCTTTATTAGATGC	0.363000													5	83					0	0	1.23904e-05	0	0
LEMD3	23592	broad.mit.edu	37	12	65564456	65564456	+	Silent	SNP	C	C	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr12:65564456C>T	ENST00000308330.2	+	1	1106	c.1080C>T	c.(1078-1080)aaC>aaT	p.N360N	LEMD3_ENST00000541171.1_Intron	NM_001167614.1|NM_014319.4	NP_001161086.1|NP_055134.2	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	360					negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	36			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		ACCGTGTTAACGCTAAGAAAC	0.552000													7	31					0	0	5.18039e-06	0	0
DYNC2LI1	51626	broad.mit.edu	37	2	44021765	44021765	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr2:44021765A>G	ENST00000260605.8	+	6	590	c.490A>G	c.(490-492)Atg>Gtg	p.M164V	DYNC2LI1_ENST00000443170.3_Missense_Mutation_p.M38V|DYNC2LI1_ENST00000605786.1_Missense_Mutation_p.M164V|DYNC2LI1_ENST00000406852.3_Missense_Mutation_p.M164V|DYNC2LI1_ENST00000398823.2_3'UTR|DYNC2LI1_ENST00000489222.2_3'UTR	NM_001193464.1|NM_016008.3	NP_001180393.1|NP_057092.2	Q8TCX1	DC2L1_HUMAN	dynein, cytoplasmic 2, light intermediate chain 1	164						apical part of cell|axonemal dynein complex|cilium axoneme|cytoplasm|microtubule|motile primary cilium	motor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|skin(1)	26		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CTGGAATAATATGCCGAAGGA	0.363000													106	302					0	0	2.47226e-05	0	0
CECR1	51816	broad.mit.edu	37	22	17688079	17688079	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr22:17688079C>T	ENST00000399839.1	-	3	694	c.424G>A	c.(424-426)Ggg>Agg	p.G142R	CECR1_ENST00000262607.3_Missense_Mutation_p.G142R|CECR1_ENST00000449907.2_Missense_Mutation_p.G100R|CECR1_ENST00000399837.2_Missense_Mutation_p.G142R			Q9NZK5	CECR1_HUMAN	cat eye syndrome chromosome region, candidate 1	142	PRB domain.				adenosine catabolic process|hypoxanthine salvage|inosine biosynthetic process|multicellular organismal development|purine ribonucleoside monophosphate biosynthetic process	extracellular space|Golgi apparatus	adenosine deaminase activity|adenosine receptor binding|growth factor activity|heparin binding|protein homodimerization activity|proteoglycan binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(6)|liver(1)|lung(10)|ovary(2)|prostate(2)|stomach(1)	25		all_epithelial(15;0.0152)|Lung NSC(13;0.0875)|all_lung(157;0.106)				TGCATGATCCCCCTTGGGGTG	0.532000													45	15					0	0	2.47226e-05	0	0
AIRE	326	broad.mit.edu	37	21	45706946	45706946	+	Silent	SNP	G	G	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr21:45706946G>A	ENST00000291582.5	+	3	520	c.393G>A	c.(391-393)aaG>aaA	p.K131K		NM_000383.3	NP_000374.1	O43918	AIRE_HUMAN	autoimmune regulator	131					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)|urinary_tract(1)	14				Colorectal(79;0.0806)		TCCCCACCAAGAGGAAGGCCT	0.697000									Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy				5	17					0	0	3.59834e-05	0	0
FRG1B	284802	broad.mit.edu	37	20	29628251	29628251	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr20:29628251A>G	ENST00000278882.3	+	6	633	c.253A>G	c.(253-255)Aat>Gat	p.N85D	FRG1B_ENST00000358464.4_Missense_Mutation_p.N85D|FRG1B_ENST00000439954.2_Missense_Mutation_p.N90D														p.N85D(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTTGGCCTCAAATAGCTGCTT	0.358000													6	86					0	0	1.12685e-05	0	0
TFR2	7036	broad.mit.edu	37	7	100226876	100226876	+	Splice_Site	SNP	C	C	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr7:100226876C>T	ENST00000462107.1	-	11	1677	c.1390_splice	c.e11+1	p.G464_splice	TFR2_ENST00000223051.3_Splice_Site_p.G464_splice|TFR2_ENST00000431692.1_3'UTR|TFR2_ENST00000544242.1_Splice_Site_p.G5_splice			Q9UP52	TFR2_HUMAN	transferrin receptor 2	464					cellular iron ion homeostasis|iron ion transport|proteolysis	cytoplasm|integral to plasma membrane	peptidase activity|transferrin receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(1)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					CTGACCTTACCGTTGCTCACC	0.657000													10	76					0	0	5.50884e-06	0	0
FAM211A	388341	broad.mit.edu	37	17	16347246	16347246	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr17:16347246G>A	ENST00000409083.3	-	3	737	c.575C>T	c.(574-576)cCg>cTg	p.P192L	C17orf76-AS1_ENST00000472367.1_RNA|C17orf76-AS1_ENST00000478103.2_RNA|C17orf76-AS1_ENST00000584177.1_RNA|C17orf76-AS1_ENST00000583400.2_RNA|C17orf76-AS1_ENST00000579473.1_RNA|C17orf76-AS1_ENST00000580770.1_RNA|C17orf76-AS1_ENST00000581718.1_RNA|FAM211A_ENST00000470794.1_Missense_Mutation_p.R231C	NM_207387.3	NP_997270.2	Q8NAA5	CQ076_HUMAN	family with sequence similarity 211, member A	330										lung(1)	1						GTGGTGAGGCGGGGCAGGGTG	0.632000													6	24					0	0	3.59834e-05	0	0
SLITRK1	114798	broad.mit.edu	37	13	84453583	84453583	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr13:84453583T>C	ENST00000377084.2	-	1	2945	c.2060A>G	c.(2059-2061)tAt>tGt	p.Y687C		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	687						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GCCACAGTCATACACTCTGTG	0.587000													7	18					0	0	2.0095e-06	0	0
SIGLEC11	114132	broad.mit.edu	37	19	50455562	50455562	+	Missense_Mutation	SNP	C	C	T	rs140702198	byFrequency	TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr19:50455562C>T	ENST00000447370.2	-	9	1831	c.1741G>A	c.(1741-1743)Gtc>Atc	p.V581I	SIGLEC11_ENST00000426971.2_Missense_Mutation_p.V485I|CTC-326K19.6_ENST00000451973.1_Intron	NM_052884.2	NP_443116.2	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11	581					cell adhesion	integral to membrane	sugar binding	p.V569I(1)|p.V581I(1)		breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(6)|pancreas(1)|prostate(1)|skin(1)	32		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		TACCTGAAGACGACAAGGCAG	0.622000													20	25					0	0	3.10358e-05	0	0
AQP12A	375318	broad.mit.edu	37	2	241631380	241631380	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr2:241631380T>A	ENST00000429564.1	+	1	113	c.50T>A	c.(49-51)cTc>cAc	p.L17H	AQP12A_ENST00000337801.4_Missense_Mutation_p.L17H			Q8IXF9	AQ12A_HUMAN	aquaporin 12A	17						integral to membrane	transporter activity			endometrium(2)|kidney(3)|large_intestine(2)|lung(7)	14		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;2.2e-31)|all cancers(36;1.08e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.52e-06)|Lung(119;0.00163)|LUSC - Lung squamous cell carcinoma(224;0.008)|Colorectal(34;0.0124)|COAD - Colon adenocarcinoma(134;0.0757)		ACCTTCGCCCTCTGTGAGGCG	0.687000													6	33					0	0	2.0095e-06	0	0
TAS2R46	259292	broad.mit.edu	37	12	11214123	11214123	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr12:11214123G>C	ENST00000533467.1	-	1	770	c.771C>G	c.(769-771)aaC>aaG	p.N257K	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_176887.2	NP_795368.2	P59540	T2R46_HUMAN	taste receptor, type 2, member 46	257					sensory perception of taste	cilium membrane|integral to membrane	G-protein coupled receptor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(49;0.0344)	BRCA - Breast invasive adenocarcinoma(232;0.196)		AGACAGGTTTGTTTTCCAGAC	0.408000													33	183					0	0	1.17478e-05	0	0
PTBP2	58155	broad.mit.edu	37	1	97278427	97278427	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr1:97278427C>T	ENST00000236228.6	+	12	1413	c.1331C>T	c.(1330-1332)tCc>tTc	p.S444F	PTBP2_ENST00000370197.1_Missense_Mutation_p.S449F|PTBP2_ENST00000394184.3_Missense_Mutation_p.S460F|PTBP2_ENST00000370198.1_Missense_Mutation_p.S449F|PTBP2_ENST00000541987.1_3'UTR|PTBP2_ENST00000426398.2_Missense_Mutation_p.S444F|PTBP2_ENST00000482253.1_3'UTR	NM_021190.2	NP_067013.1	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	444							nucleotide binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|skin(1)	26		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		AAACCTGGATCCAAAAATTTT	0.373000													9	26					0	0	2.17888e-05	0	0
TPTE	7179	broad.mit.edu	37	21	11012916	11012916	+	Splice_Site	SNP	C	C	A	rs4041777		TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr21:11012916C>A	ENST00000415664.2	-	8	1004		c.e8+1					P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCAAATTTTACCTAGCTTTTT	0.299000													29	44					1.77063e-15	3.25429e-13	1.32003e-05	1	0
CHRM3	1131	broad.mit.edu	37	1	240071307	240071307	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr1:240071307G>C	ENST00000255380.4	+	5	1335	c.556G>C	c.(556-558)Ggt>Cgt	p.G186R		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	186					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	AAAGAGAGCCGGTGTGATGAT	0.502000													5	134					0	0	5.18039e-06	0	0
KCNC2	3747	broad.mit.edu	37	12	75444669	75444669	+	Silent	SNP	T	T	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr12:75444669T>A	ENST00000549446.1	-	3	1796	c.1116A>T	c.(1114-1116)ggA>ggT	p.G372G	KCNC2_ENST00000540018.1_Silent_p.G372G|KCNC2_ENST00000393288.2_Silent_p.G372G|KCNC2_ENST00000548243.1_5'UTR|KCNC2_ENST00000341669.3_Silent_p.G372G|KCNC2_ENST00000548513.1_Silent_p.G372G|KCNC2_ENST00000550433.1_Silent_p.G372G|KCNC2_ENST00000350228.2_Silent_p.G372G|KCNC2_ENST00000298972.1_Silent_p.G372G	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	372					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						GAAGAGTATGTCCAAGCACCC	0.443000													5	22					0	0	1.23904e-05	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				74	11					0	0	2.47226e-05	0	0
TUBA3D	113457	broad.mit.edu	37	2	132238267	132238267	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr2:132238267C>T	ENST00000321253.6	+	4	1108	c.1001C>T	c.(1000-1002)aCc>aTc	p.T334I		NM_080386.3	NP_525125.2	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	334					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32				BRCA - Breast invasive adenocarcinoma(221;0.13)		GCCATCGCCACCATCAAGACC	0.562000													10	38					0	0	3.86212e-05	0	0
MAGEB3	4114	broad.mit.edu	37	X	30254167	30254167	+	Silent	SNP	C	C	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chrX:30254167C>T	ENST00000361644.2	+	5	863	c.126C>T	c.(124-126)tcC>tcT	p.S42S	MAGEB3_ENST00000378986.1_Silent_p.S42S	NM_002365.4	NP_002356.2	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	42										NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	25						CCTTTTCATCCCCTCTTATTT	0.498000													11	8					0	0	6.40141e-05	0	0
ZNF248	57209	broad.mit.edu	37	10	38120724	38120724	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr10:38120724T>C	ENST00000395867.3	-	6	2109	c.1559A>G	c.(1558-1560)tAt>tGt	p.Y520C	ZNF248_ENST00000374648.3_Intron|ZNF248_ENST00000357328.4_Missense_Mutation_p.Y520C|ZNF248_ENST00000494133.1_Intron	NM_001267605.1|NM_001267606.1|NM_001267607.1|NM_021045.2	NP_001254534.1|NP_001254535.1|NP_001254536.1|NP_066383.1	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	520					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(2)|urinary_tract(1)	20						ATTACACTTATATGGTTTCTC	0.408000													19	18					0	0	8.00594e-06	0	0
PCDHB4	56131	broad.mit.edu	37	5	140502272	140502272	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr5:140502272T>A	ENST00000194152.1	+	1	692	c.692T>A	c.(691-693)aTc>aAc	p.I231N		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		231	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGAATCCTGATCATGGACATC	0.537000													12	53					0	0	1.49906e-05	0	0
ARMCX5	64860	broad.mit.edu	37	X	101857274	101857274	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chrX:101857274G>A	ENST00000604957.1	+	1	2827	c.205G>A	c.(205-207)Gag>Aag	p.E69K	RP4-769N13.6_ENST00000476910.1_RNA|ARMCX5_ENST00000541409.1_Missense_Mutation_p.E69K|ARMCX5_ENST00000537008.1_Missense_Mutation_p.E69K|ARMCX5_ENST00000246174.2_Missense_Mutation_p.E69K|ARMCX5_ENST00000536530.1_Missense_Mutation_p.E69K|ARMCX5_ENST00000372742.1_Missense_Mutation_p.E69K|RP4-769N13.7_ENST00000602441.1_RNA	NM_001168478.1	NP_001161950.1	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	69							binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	22						GACCTACAGGGAGGCTATGGC	0.507000													13	47					0	0	9.31168e-06	0	0
LOC101928517	101928517	broad.mit.edu	37	19	51671531	51671531	+	RNA	SNP	C	C	T	rs139300887	by1000genomes	TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr19:51671531C>T	ENST00000600074.1	-	0	493				SIGLEC17P_ENST00000598286.1_RNA																							GATCATCCCACGGCCTCAGGA	0.627000													5	13					0	0	1.23904e-05	0	0
KCTD7	154881	broad.mit.edu	37	7	66104168	66104168	+	Silent	SNP	C	C	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr7:66104168C>T	ENST00000275532.3	+	4	1003	c.819C>T	c.(817-819)aaC>aaT	p.N273N	KCTD7_ENST00000443322.1_Silent_p.N273N	NM_001167961.2|NM_153033.4	NP_001161433.1|NP_694578.1	Q96MP8	KCTD7_HUMAN	potassium channel tetramerization domain containing 7	273						voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|urinary_tract(1)	16						ACCTCGTGAACCACTACTACT	0.577000													12	32					0	0	5.50884e-06	0	0
FOCAD	54914	broad.mit.edu	37	9	20820362	20820362	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr9:20820362G>A	ENST00000380249.1	+	15	1964	c.1600G>A	c.(1600-1602)Gga>Aga	p.G534R	FOCAD_ENST00000605086.1_5'UTR|FOCAD_ENST00000338382.6_Missense_Mutation_p.G534R	NM_017794.3	NP_060264.3	Q5VW36	K1797_HUMAN	focadhesin	534						integral to membrane	binding										ACAACTACTTGGAACCACACC	0.378000													33	16					0	0	4.2857e-05	0	0
FOCAD	54914	broad.mit.edu	37	9	20820363	20820363	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr9:20820363G>A	ENST00000380249.1	+	15	1965	c.1601G>A	c.(1600-1602)gGa>gAa	p.G534E	FOCAD_ENST00000605086.1_5'UTR|FOCAD_ENST00000338382.6_Missense_Mutation_p.G534E	NM_017794.3	NP_060264.3	Q5VW36	K1797_HUMAN	focadhesin	534						integral to membrane	binding										CAACTACTTGGAACCACACCA	0.373000													34	16					0	0	6.26518e-05	0	0
TFAP2D	83741	broad.mit.edu	37	6	50712873	50712873	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr6:50712873C>T	ENST00000008391.3	+	6	1165	c.937C>T	c.(937-939)Cca>Tca	p.P313S	TFAP2D_ENST00000492804.1_3'UTR	NM_172238.3	NP_758438.2	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)	313	H-S-H (helix-span-helix), dimerization.						DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(26)|ovary(6)|pancreas(1)|prostate(5)|stomach(1)	60	Lung NSC(77;0.0334)					AACAGAGTTTCCAGCCAAAGC	0.453000													18	19					0	0	8.00594e-06	0	0
PLEKHA4	57664	broad.mit.edu	37	19	49362784	49362784	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr19:49362784G>A	ENST00000263265.6	-	7	1189	c.634C>T	c.(634-636)Ccc>Tcc	p.P212S	PLEKHA4_ENST00000596713.1_5'UTR|PLEKHA4_ENST00000355496.5_Missense_Mutation_p.P212S	NM_020904.2	NP_065955.2	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	212	Pro-rich.					cytoplasm|membrane	1-phosphatidylinositol binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	30		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		GTGGGGCTGGGAGTGAGCAGC	0.632000													8	20					0	0	2.17888e-05	0	0
NRCAM	4897	broad.mit.edu	37	7	107823349	107823349	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr7:107823349C>T	ENST00000379028.3	-	23	2790	c.2320G>A	c.(2320-2322)Gaa>Aaa	p.E774K	NRCAM_ENST00000379022.4_Missense_Mutation_p.E774K|NRCAM_ENST00000379024.4_Missense_Mutation_p.E755K|NRCAM_ENST00000351718.4_Missense_Mutation_p.E758K|NRCAM_ENST00000413765.2_Missense_Mutation_p.E755K|NRCAM_ENST00000425651.2_Missense_Mutation_p.E774K			Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule	774	Fibronectin type-III 2.				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(1)|lung(36)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	65						CCATTAGATTCGAAACCATTC	0.413000													6	47					0	0	2.0095e-06	0	0
ST18	9705	broad.mit.edu	37	8	53084780	53084780	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr8:53084780T>C	ENST00000276480.7	-	10	1324	c.641A>G	c.(640-642)aAa>aGa	p.K214R		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	214						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TCTAGGTGGTTTGGTTTCTTC	0.408000													6	42					0	0	3.59834e-05	0	0
GPM6A	2823	broad.mit.edu	37	4	176561960	176561960	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr4:176561960C>T	ENST00000280187.7	-	6	607	c.562G>A	c.(562-564)Gaa>Aaa	p.E188K	GPM6A_ENST00000393658.2_Missense_Mutation_p.E188K|GPM6A_ENST00000506894.1_Missense_Mutation_p.E177K|GPM6A_ENST00000515090.1_Missense_Mutation_p.E181K|GPM6A_ENST00000506219.1_5'UTR	NM_005277.4	NP_005268.1	P51674	GPM6A_HUMAN	glycoprotein M6A	188						cell surface|integral to membrane		p.E188K(1)		NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		ATTTTCTTTTCCTCTCCAATT	0.338000													10	21					0	0	6.40141e-05	0	0
GRIA3	2892	broad.mit.edu	37	X	122551412	122551412	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chrX:122551412G>A	ENST00000264357.5	+	11	1952	c.1660G>A	c.(1660-1662)Gaa>Aaa	p.E554K	GRIA3_ENST00000371256.5_Missense_Mutation_p.E554K|GRIA3_ENST00000541091.1_Missense_Mutation_p.E538K|GRIA3_ENST00000371251.1_Missense_Mutation_p.E554K|GRIA3_ENST00000542149.1_Missense_Mutation_p.E554K	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	554					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	CCTGGCTTATGAAATCTGGAT	0.428000													88	135					0	0	2.47226e-05	0	0
DTX1	1840	broad.mit.edu	37	12	113515257	113515257	+	Silent	SNP	C	C	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr12:113515257C>T	ENST00000257600.3	+	2	791	c.288C>T	c.(286-288)ttC>ttT	p.F96F		NM_004416.2	NP_004407.2	Q86Y01	DTX1_HUMAN	deltex homolog 1 (Drosophila)	96	WWE 2.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	32						GGCGCAACTTCTACGACCCGT	0.672000													6	23					0	0	3.59834e-05	0	0
TFIP11	24144	broad.mit.edu	37	22	26894937	26894937	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr22:26894937C>G	ENST00000407690.1	-	10	1617	c.1334G>C	c.(1333-1335)tGc>tCc	p.C445S	TFIP11_ENST00000405938.1_Missense_Mutation_p.C445S|TFIP11_ENST00000407148.1_Missense_Mutation_p.C445S|TFIP11_ENST00000407431.1_Missense_Mutation_p.C445S	NM_012143.2	NP_036275.1	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	445					biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	25						GCCATAAGTGCAGTCCTGAGG	0.557000													16	60					0	0	3.45872e-05	0	0
HERC4	26091	broad.mit.edu	37	10	69785421	69785421	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr10:69785421A>G	ENST00000395198.3	-	8	1037	c.790T>C	c.(790-792)Ttt>Ctt	p.F264L	HERC4_ENST00000395187.2_3'UTR|HERC4_ENST00000412272.2_Missense_Mutation_p.F264L|HERC4_ENST00000373700.4_Missense_Mutation_p.F264L|HERC4_ENST00000277817.6_Missense_Mutation_p.F154L	NM_022079.2	NP_071362.1	Q5GLZ8	HERC4_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 4	264					cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	27						CCAAAAGTAAACACTCCACCT	0.358000													26	23					0	0	2.90539e-05	0	0
CKAP2L	150468	broad.mit.edu	37	2	113514717	113514717	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr2:113514717T>G	ENST00000302450.6	-	4	309	c.231A>C	c.(229-231)aaA>aaC	p.K77N	CKAP2L_ENST00000541405.1_5'UTR|CKAP2L_ENST00000481732.1_5'UTR	NM_152515.3	NP_689728.3	Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	77						centrosome				breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	28						TGGGCTGGAGTTTAATGCTGA	0.413000													27	99					0	0	1.7367e-05	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803493	142803493	+	RNA	SNP	T	T	C	rs80149641	by1000genomes	TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr1:142803493T>C	ENST00000423385.1	-	0	1472																											TGTACATTTATTATTGATTTA	0.323000													12	112					0	0	6.40141e-05	0	0
RRP15	51018	broad.mit.edu	37	1	218458675	218458675	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr1:218458675C>G	ENST00000366932.3	+	1	47	c.17C>G	c.(16-18)cCg>cGg	p.P6R		NM_016052.3	NP_057136.2	Q9Y3B9	RRP15_HUMAN	ribosomal RNA processing 15 homolog (S. cerevisiae)	6						mitochondrion|nucleolus	protein binding		ACBD6/RRP15(2)	NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	14				all cancers(67;0.0315)|OV - Ovarian serous cystadenocarcinoma(81;0.0411)|GBM - Glioblastoma multiforme(131;0.06)|Epithelial(68;0.248)		GCCGCCGCTCCGGACTCACGT	0.547000													21	19					0	0	3.10358e-05	0	0
HSPG2	3339	broad.mit.edu	37	1	22178171	22178171	+	Silent	SNP	G	G	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr1:22178171G>A	ENST00000374695.3	-	55	7105	c.7026C>T	c.(7024-7026)ccC>ccT	p.P2342P	HSPG2_ENST00000430507.1_3'UTR	NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	2342	Ig-like C2-type 9.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CGATGCGGATGGGCTGGGTGC	0.642000													8	34					0	0	3.86212e-05	0	0
C17orf80	55028	broad.mit.edu	37	17	71231869	71231869	+	Missense_Mutation	SNP	T	T	G	rs148616003		TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr17:71231869T>G	ENST00000359042.2	+	3	442	c.248T>G	c.(247-249)gTg>gGg	p.V83G	C17orf80_ENST00000255557.4_Missense_Mutation_p.V83G|FAM104A_ENST00000583178.1_Intron|C17orf80_ENST00000268942.8_Missense_Mutation_p.V83G|C17orf80_ENST00000577615.1_Missense_Mutation_p.V83G|C17orf80_ENST00000426147.2_Missense_Mutation_p.V83G|C17orf80_ENST00000582793.1_Intron|C17orf80_ENST00000535032.2_Missense_Mutation_p.V83G	NM_017941.4	NP_060411.2	Q9BSJ5	CQ080_HUMAN	chromosome 17 open reading frame 80	83						integral to membrane				kidney(1)|large_intestine(5)|lung(2)|skin(2)|stomach(2)|urinary_tract(2)	14			LUSC - Lung squamous cell carcinoma(166;0.197)			AAGTTGGTGGTGGACAAACCA	0.398000													11	32					0	0	6.40141e-05	0	0
UPF2	26019	broad.mit.edu	37	10	11994238	11994238	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr10:11994238C>A	ENST00000356352.2	-	14	3334	c.2861G>T	c.(2860-2862)tGg>tTg	p.W954L	UPF2_ENST00000357604.5_Missense_Mutation_p.W954L|UPF2_ENST00000397053.2_Missense_Mutation_p.W954L			Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog (yeast)	954	MIF4G 3.|Sufficient for interaction with EIF4A1 and EIF1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(14)|lung(17)|ovary(2)|skin(3)|urinary_tract(2)	56		Renal(717;0.228)				TTTCTTCCACCAAACATAACG	0.294000													9	216					1.58986e-06	0.000286794	3.86212e-05	1	0
ROR2	4920	broad.mit.edu	37	9	94486904	94486904	+	Silent	SNP	G	G	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr9:94486904G>A	ENST00000375708.3	-	9	2070	c.1872C>T	c.(1870-1872)taC>taT	p.Y624Y	ROR2_ENST00000375715.1_Silent_p.Y484Y|ROR2_ENST00000550066.1_5'UTR	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	624	Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						TCAGCTTGTCGTACACTAGCA	0.577000													13	59					0	0	9.31168e-06	0	0
GNRHR2	114814	broad.mit.edu	37	1	145513702	145513703	+	RNA	DEL	CC	CC	-			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr1:145513702_145513703delCC	ENST00000312753.5	-	0	888																											CCTCCATCCTCCCTAGCAtttc	0.411													2	4	---	---	---	---					
PXDN	7837	broad.mit.edu	37	2	1637997	1637998	+	Frame_Shift_Ins	INS	-	-	TT			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr2:1637997_1637998insTT	ENST00000252804.4	-	23	4468_4469	c.4418_4419insAA	c.(4417-4419)aagfs	p.K1473fs		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	1473					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CCTCCGCCCTCTTCTGTAAGCA	0.639													2	4	---	---	---	---					
ETV7	51513	broad.mit.edu	37	6	36341294	36341294	+	Frame_Shift_Del	DEL	C	C	-	rs3213530	byFrequency	TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr6:36341294delC	ENST00000373738.1	-	3	1049	c.204delG	c.(202-204)ggfs	p.G68fs	ETV7_ENST00000340181.4_Frame_Shift_Del_p.G123fs|ETV7_ENST00000538992.1_5'UTR|ETV7_ENST00000373737.4_Frame_Shift_Del_p.G123fs|ETV7_ENST00000339796.5_Frame_Shift_Del_p.G123fs	NM_001207036.1	NP_001193965.1	Q9Y603	ETV7_HUMAN	ets variant 7	123	PNT.				organ morphogenesis|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|skin(4)	10						CAAAAAAGGGCCCACACACCA	0.627													2	4	---	---	---	---					
EIF3B	8662	broad.mit.edu	37	7	2419064	2419064	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr7:2419064delG	ENST00000360876.4	+	18	2433	c.2377delG	c.(2377-2379)acfs	p.D793fs	EIF3B_ENST00000397011.2_Frame_Shift_Del_p.D793fs	NM_001037283.1	NP_001032360.1	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3, subunit B	793			D -> E (in dbSNP:rs1063257).		regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	24		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		CAACGTGGACGACTGGGAAGA	0.602													2	4	---	---	---	---					
NSUN5P1	155400	broad.mit.edu	37	7	75045497	75045497	+	RNA	DEL	G	G	-			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr7:75045497delG	ENST00000393633.2	+	0	4280																				large_intestine(1)|lung(1)	2						GGGTCGTGGAGGGGGGGGATG	0.657													2	4	---	---	---	---					
CD44	960	broad.mit.edu	37	11	35160867	35160867	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr11:35160867delG	ENST00000263398.6	+	1	451	c.17delG	c.(16-18)tgfs	p.W6fs	CD44_ENST00000449691.2_Frame_Shift_Del_p.W6fs|CD44_ENST00000437706.2_Frame_Shift_Del_p.W6fs|CD44_ENST00000433354.2_Frame_Shift_Del_p.W6fs|CD44_ENST00000428726.2_Frame_Shift_Del_p.W6fs|CD44_ENST00000526669.2_Frame_Shift_Del_p.W6fs|CD44_ENST00000352818.4_Frame_Shift_Del_p.W6fs|CD44_ENST00000526025.1_Frame_Shift_Del_p.W6fs|CD44_ENST00000278386.6_Frame_Shift_Del_p.W6fs|CD44_ENST00000434472.2_Frame_Shift_Del_p.W6fs|CD44_ENST00000360158.4_Frame_Shift_Del_p.W6fs|CD44_ENST00000433892.2_Frame_Shift_Del_p.W6fs|CD44_ENST00000415148.2_Frame_Shift_Del_p.W6fs	NM_001001391.1|NM_001202555.1|NM_001202556.1	NP_001001391.1|NP_001189484.1|NP_001189485.1	P16070	CD44_HUMAN	CD44 molecule (Indian blood group)	6					cell-cell adhesion|cell-matrix adhesion|interferon-gamma-mediated signaling pathway|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation	cell surface|Golgi apparatus|integral to plasma membrane	collagen binding|hyaluronic acid binding|receptor activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(13)|pancreas(1)|skin(1)	23	all_cancers(35;0.212)|all_lung(20;0.0874)|all_epithelial(35;0.112)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.00731)		Hyaluronidase(DB00070)	AAGTTTTGGTGGCACGCAGCC	0.716													2	4	---	---	---	---					
RP11-44F14.1	0	broad.mit.edu	37	16	53404542	53404543	+	RNA	INS	-	-	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr16:53404542_53404543insA	ENST00000565421.1	-	0	410																											TCTCCTTTCTCAAACTTAACCT	0.327													7	45	---	---	---	---					
CDH19	28513	broad.mit.edu	37	18	64197127	64197128	+	Frame_Shift_Ins	INS	-	-	G			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr18:64197127_64197128insG	ENST00000262150.2	-	9	1704_1705	c.1412_1413insC	c.(1411-1413)tcafs	p.S471fs	CDH19_ENST00000540086.1_Frame_Shift_Ins_p.S471fs	NM_021153.2	NP_066976.1	Q9H159	CAD19_HUMAN	cadherin 19, type 2	471	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(22)|ovary(1)|prostate(3)|skin(7)	61		Esophageal squamous(42;0.0132)				CATAGTATTGAGAGAACTCAGG	0.317													25	92	---	---	---	---					
OR7E24	26648	broad.mit.edu	37	19	9361741	9361741	+	Frame_Shift_Del	DEL	T	T	-			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr19:9361741delT	ENST00000456448.1	+	1	136	c.22delT	c.(22-24)ttfs	p.F11fs		NM_001079935.1	NP_001073404.1	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E, member 24	11					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)	16						TCCAATTCTCTTTTTTTTTTT	0.388													3	5	---	---	---	---					
LDOC1	23641	broad.mit.edu	37	X	140271057	140271063	+	Frame_Shift_Del	DEL	CGGGCAG	CGGGCAG	-			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chrX:140271057_140271063delCGGGCAG	ENST00000370526.2	-	1	247_253	c.144_150delCTGCCCG	c.(142-150)agfs	p.SCP48fs	LDOC1_ENST00000460721.1_Intron	NM_012317.2	NP_036449.1	O95751	LDOC1_HUMAN	leucine zipper, down-regulated in cancer 1	48					negative regulation of cell proliferation	nucleus	protein binding	p.P50L(1)		endometrium(6)|large_intestine(1)|lung(6)|ovary(1)	14	Acute lymphoblastic leukemia(192;7.65e-05)					GGAAGGGCACCGGGCAGCTCGGCGGAC	0.638													8	12	---	---	---	---