Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KLK8	11202	broad.mit.edu	37	19	51499342	51499342	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr19:51499342G>C	ENST00000600767.1	-	7	1245	c.756C>G	c.(754-756)atC>atG	p.I252M	CTB-147C22.9_ENST00000594512.1_RNA|KLK8_ENST00000593490.1_3'UTR|KLK8_ENST00000347619.4_Missense_Mutation_p.I111M|KLK8_ENST00000291726.7_Missense_Mutation_p.I252M|KLK8_ENST00000320838.5_3'UTR|KLK8_ENST00000598195.1_5'UTR|KLK8_ENST00000391806.2_Missense_Mutation_p.I297M			O60259	KLK8_HUMAN	kallikrein-related peptidase 8	252	Peptidase S1.				cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|prostate(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		TGATCTTCTTGATCCAGTCCA	0.522000													23	105					0	0	0.00395357	0	0
ZMYND10	51364	broad.mit.edu	37	3	50379244	50379244	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr3:50379244C>G	ENST00000231749.3	-	10	2390	c.1118G>C	c.(1117-1119)cGa>cCa	p.R373P	ZMYND10-AS1_ENST00000440013.1_RNA|ZMYND10_ENST00000490675.1_5'UTR|ZMYND10_ENST00000360165.3_Missense_Mutation_p.R368P	NM_015896.2	NP_056980.2	O75800	ZMY10_HUMAN	zinc finger, MYND-type containing 10	373						cytoplasm	protein binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(1)|lung(5)|ovary(1)|urinary_tract(2)	14				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GCCTTACCTTCGCGCCTGCAG	0.632000										TSP Lung(30;0.18)			10	24					0	0	0.000673444	0	0
ARHGAP10	79658	broad.mit.edu	37	4	148944547	148944547	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr4:148944547G>A	ENST00000336498.3	+	19	2089	c.1850G>A	c.(1849-1851)tGt>tAt	p.C617Y	ARHGAP10_ENST00000414545.2_Missense_Mutation_p.C266Y	NM_024605.3	NP_078881.3	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10	617					apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			autonomic_ganglia(2)|endometrium(5)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		TACAATCTTTGTCTGGAGCTG	0.507000													13	30					0	0	0.00316338	0	0
CIC	23152	broad.mit.edu	37	19	42793213	42793213	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr19:42793213G>A	ENST00000572681.2	+	8	3900	c.3832G>A	c.(3832-3834)Gac>Aac	p.D1278N	CIC_ENST00000160740.3_Missense_Mutation_p.D369N|CIC_ENST00000575354.2_Missense_Mutation_p.D369N			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	369	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				CGGAGAAGTAGACAGTCAGGC	0.667000			"""Mis, F, S"""		oligodendroglioma								14	58					0	0	0.00244969	0	0
KRTAP1-3	81850	broad.mit.edu	37	17	39191032	39191032	+	Silent	SNP	G	G	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr17:39191032G>A	ENST00000344363.5	-	1	75	c.42C>T	c.(40-42)tgC>tgT	p.C14C		NM_030966.1	NP_112228.1	Q8IUG1	KRA13_HUMAN	keratin associated protein 1-3	14						extracellular region|keratin filament	structural constituent of epidermis			cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(6)	12		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			CACTGGTGGAGCAGCTGGGAT	0.577000													14	55					0	0	0.00185496	0	0
LST3	0	broad.mit.edu	37	12	21205150	21205150	+	Silent	SNP	T	T	G			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr12:21205150T>G	ENST00000381541.3	+	10	1517	c.1452T>G	c.(1450-1452)ccT>ccG	p.P484P	SLCO1B7_ENST00000421593.2_Silent_p.P437P|LST3_ENST00000540229.1_Intron|SLCO1B7_ENST00000554957.1_Silent_p.P484P|SLCO1B3_ENST00000553473.1_Intron																							ACCTGTCACCTTGTCTAGCAG	0.373000													8	212					0	0	0.000274275	0	0
CECR6	27439	broad.mit.edu	37	22	17600670	17600670	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr22:17600670C>T	ENST00000331437.3	-	1	1473	c.1348G>A	c.(1348-1350)Gcc>Acc	p.A450T	CECR6_ENST00000399875.1_Missense_Mutation_p.A95T	NM_031890.3	NP_114096.1	Q9BXQ6	CECR6_HUMAN	cat eye syndrome chromosome region, candidate 6	450	Poly-Ala.									haematopoietic_and_lymphoid_tissue(1)	1		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.221)		GCCGCTGCGGCCGCGGCGTTG	0.731000													3	2					0	0	6.4e-05	0	0
HSP90AB1	3326	broad.mit.edu	37	6	44218202	44218202	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr6:44218202A>G	ENST00000371554.1	+	6	1037	c.823A>G	c.(823-825)Aaa>Gaa	p.K275E	HSP90AB1_ENST00000353801.3_Missense_Mutation_p.K275E|HSP90AB1_ENST00000371646.5_Missense_Mutation_p.K275E			P08238	HS90B_HUMAN	heat shock protein 90kDa alpha (cytosolic), class B member 1	275					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(12)|prostate(2)|skin(2)|urinary_tract(2)	33	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			gatcaaagagaaATACATTGA	0.403000													8	34					0	0	0.00307968	0	0
XIST	7503	broad.mit.edu	37	X	73062205	73062205	+	RNA	SNP	A	A	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chrX:73062205A>T	ENST00000429829.1	-	0	10383					NR_001564.2																						AAAATAAAGGATGGCAATCCA	0.458000													3	5					0	0	0.00024832	0	0
MALAT1	378938	broad.mit.edu	37	11	65265689	65265689	+	RNA	SNP	A	A	T	rs137885794	by1000genomes	TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr11:65265689A>T	ENST00000534336.1	+	0	457				AP000769.7_ENST00000602344.1_lincRNA	NR_002819.2																						CCATTCGCTTAGTTGGTCTAC	0.488000													10	23					0	0	0.000673444	0	0
HGF	3082	broad.mit.edu	37	7	81346642	81346642	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr7:81346642C>G	ENST00000222390.5	-	11	1537	c.1311G>C	c.(1309-1311)gaG>gaC	p.E437D	HGF_ENST00000457544.2_Missense_Mutation_p.E432D	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	437	Kringle 4.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						GGCAGTAATTCTCATTCAGCT	0.443000													11	38					0	0	0.000673444	0	0
DNAH17	8632	broad.mit.edu	37	17	76498698	76498698	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr17:76498698G>A	ENST00000389840.5	-	33	5256	c.5132C>T	c.(5131-5133)gCt>gTt	p.A1711V	DNAH17_ENST00000585328.1_Missense_Mutation_p.A1719V|DNAH17-AS1_ENST00000598378.1_3'UTR					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			ATCTCTGATAGCGTTTTCATA	0.478000													8	10					0	0	0.00307968	0	0
UPF3A	65110	broad.mit.edu	37	13	115047559	115047559	+	Silent	SNP	C	C	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr13:115047559C>T	ENST00000375299.3	+	2	327	c.271C>T	c.(271-273)Ctg>Ttg	p.L91L	UPF3A_ENST00000351487.5_Silent_p.L91L	NM_023011.3	NP_075387.1	Q9H1J1	REN3A_HUMAN	UPF3 regulator of nonsense transcripts homolog A (yeast)	91	Required for interaction with UPF2.				mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|nucleus|plasma membrane	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding	p.L91L(8)		autonomic_ganglia(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	16	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)	OV - Ovarian serous cystadenocarcinoma(48;0.195)|Epithelial(10;0.2)		GCTGCGCCCGCTGCCAGCACA	0.731000													5	5					0	0	0.000602214	0	0
FAT4	79633	broad.mit.edu	37	4	126239466	126239466	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr4:126239466C>G	ENST00000394329.3	+	1	1913	c.1900C>G	c.(1900-1902)Ctg>Gtg	p.L634V		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	634	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GTCCTTCCGTCTGGATCCTGT	0.557000													9	21					0	0	0.000274275	0	0
KLK8	11202	broad.mit.edu	37	19	51499375	51499375	+	Silent	SNP	G	G	C			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr19:51499375G>C	ENST00000600767.1	-	7	1212	c.723C>G	c.(721-723)gtC>gtG	p.V241V	CTB-147C22.9_ENST00000594512.1_RNA|KLK8_ENST00000593490.1_3'UTR|KLK8_ENST00000347619.4_Silent_p.V100V|KLK8_ENST00000291726.7_Silent_p.V241V|KLK8_ENST00000320838.5_3'UTR|KLK8_ENST00000598195.1_5'UTR|KLK8_ENST00000391806.2_Silent_p.V286V			O60259	KLK8_HUMAN	kallikrein-related peptidase 8	241	Peptidase S1.				cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|prostate(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		TGTTGGTATAGACGCCAGGTT	0.537000													20	74					0	0	0.00188189	0	0
VRK3	51231	broad.mit.edu	37	19	50498123	50498123	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr19:50498123C>T	ENST00000599538.1	-	9	1482	c.818G>A	c.(817-819)aGc>aAc	p.S273N	VRK3_ENST00000594092.1_Missense_Mutation_p.S273N|VRK3_ENST00000594948.1_Missense_Mutation_p.S273N|VRK3_ENST00000377011.2_Missense_Mutation_p.S223N|VRK3_ENST00000316763.3_Missense_Mutation_p.S273N|VRK3_ENST00000443401.2_Missense_Mutation_p.S42N|VRK3_ENST00000601912.1_Missense_Mutation_p.S223N|VRK3_ENST00000601341.1_Missense_Mutation_p.S223N|VRK3_ENST00000424804.2_5'UTR|VRK3_ENST00000593919.1_Missense_Mutation_p.S273N			Q8IV63	VRK3_HUMAN	vaccinia related kinase 3	273	Protein kinase.					nucleus	ATP binding|protein kinase activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)|stomach(2)|urinary_tract(1)	23		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		ATGCTTTGGGCTGACATCCAG	0.617000													10	14					0	0	0.000673444	0	0
PDE2A	5138	broad.mit.edu	37	11	72293497	72293497	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr11:72293497G>C	ENST00000334456.5	-	21	2087	c.1842C>G	c.(1840-1842)gaC>gaG	p.D614E	PDE2A_ENST00000544570.1_Missense_Mutation_p.D607E|PDE2A_ENST00000444035.2_Missense_Mutation_p.D605E|PDE2A_ENST00000418754.2_Missense_Mutation_p.D499E|PDE2A_ENST00000376450.3_Missense_Mutation_p.D358E|PDE2A_ENST00000540345.1_Missense_Mutation_p.D605E	NM_002599.4	NP_002590.1	O00408	PDE2A_HUMAN	phosphodiesterase 2A, cGMP-stimulated	614					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	36			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	CCATGGACGTGTCATCCTCGG	0.512000													31	129					0	0	0.00209593	0	0
KCTD20	222658	broad.mit.edu	37	6	36446928	36446928	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr6:36446928C>A	ENST00000373731.2	+	4	856	c.465C>A	c.(463-465)ttC>ttA	p.F155L	KCTD20_ENST00000536244.1_Missense_Mutation_p.F10L|KCTD20_ENST00000449081.2_Intron|KCTD20_ENST00000474988.1_Intron|KCTD20_ENST00000544295.1_5'UTR	NM_173562.3	NP_775833.2	Q7Z5Y7	KCD20_HUMAN	potassium channel tetramerization domain containing 20	155	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|skin(1)	15						AGTACAACTTCACTCGGCCCA	0.433000													22	41					7.33532e-06	9.55259e-05	0.00395357	1	0
VRK3	51231	broad.mit.edu	37	19	50496177	50496177	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr19:50496177C>G	ENST00000599538.1	-	10	1567	c.903G>C	c.(901-903)gaG>gaC	p.E301D	VRK3_ENST00000594092.1_Missense_Mutation_p.E301D|VRK3_ENST00000594948.1_Missense_Mutation_p.E301D|VRK3_ENST00000377011.2_Missense_Mutation_p.E251D|VRK3_ENST00000316763.3_Missense_Mutation_p.E301D|VRK3_ENST00000443401.2_Missense_Mutation_p.E70D|VRK3_ENST00000601912.1_Missense_Mutation_p.E251D|VRK3_ENST00000601341.1_Missense_Mutation_p.E251D|VRK3_ENST00000424804.2_5'UTR|VRK3_ENST00000593919.1_Missense_Mutation_p.E301D			Q8IV63	VRK3_HUMAN	vaccinia related kinase 3	301	Protein kinase.					nucleus	ATP binding|protein kinase activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)|stomach(2)|urinary_tract(1)	23		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		CATGAACATACTCATTCTCAT	0.512000													21	73					0	0	0.00152264	0	0
WBP11	51729	broad.mit.edu	37	12	14947999	14947999	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr12:14947999C>T	ENST00000261167.2	-	6	660	c.427G>A	c.(427-429)Gat>Aat	p.D143N	WBP11_ENST00000537574.1_Missense_Mutation_p.D143N	NM_016312.2	NP_057396.1	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	143	Pro-rich.				mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)	30						TGTGGCATATCTGGCAAAGGA	0.428000													19	220					0	0	0.00074312	0	0
FAT4	79633	broad.mit.edu	37	4	126412858	126412858	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr4:126412858G>A	ENST00000394329.3	+	17	14894	c.14881G>A	c.(14881-14883)Gaa>Aaa	p.E4961K	FAT4_ENST00000335110.5_Missense_Mutation_p.E3202K	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4961					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AGCAGCAAATGAAGAAGGCAA	0.408000													7	10					0	0	0.00198382	0	0
KLK8	11202	broad.mit.edu	37	19	51499431	51499431	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr19:51499431G>A	ENST00000600767.1	-	7	1156	c.667C>T	c.(667-669)Cag>Tag	p.Q223*	CTB-147C22.9_ENST00000594512.1_RNA|KLK8_ENST00000593490.1_3'UTR|KLK8_ENST00000347619.4_Nonsense_Mutation_p.Q82*|KLK8_ENST00000291726.7_Nonsense_Mutation_p.Q223*|KLK8_ENST00000320838.5_3'UTR|KLK8_ENST00000598195.1_5'UTR|KLK8_ENST00000391806.2_Nonsense_Mutation_p.Q268*			O60259	KLK8_HUMAN	kallikrein-related peptidase 8	223	Peptidase S1.				cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|prostate(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		GTGATGCCCTGGAGTGCACCA	0.562000													13	53					0	0	0.00244969	0	0
B4GALNT1	2583	broad.mit.edu	37	12	58022613	58022613	+	Silent	SNP	G	G	C			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr12:58022613G>C	ENST00000341156.4	-	8	1469	c.885C>G	c.(883-885)ctC>ctG	p.L295L	B4GALNT1_ENST00000418555.2_Silent_p.L240L|B4GALNT1_ENST00000449184.3_Silent_p.L262L	NM_001478.3	NP_001469.1	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	295					lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|urinary_tract(1)	20	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			TACTGGTGATGAGAGCCCGTA	0.577000													29	162					0	0	0.00127121	0	0
IL17RD	54756	broad.mit.edu	37	3	57132135	57132135	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr3:57132135G>T	ENST00000296318.7	-	12	1684	c.1596C>A	c.(1594-1596)aaC>aaA	p.N532K	IL17RD_ENST00000320057.5_Missense_Mutation_p.N388K|IL17RD_ENST00000463523.1_Missense_Mutation_p.N388K|IL17RD_ENST00000427856.2_Missense_Mutation_p.N508K	NM_017563.3	NP_060033.3	Q8NFM7	I17RD_HUMAN	interleukin 17 receptor D	532						Golgi membrane|integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(1)|ovary(1)|pancreas(1)	16				KIRC - Kidney renal clear cell carcinoma(284;0.0173)|Kidney(284;0.0204)		TCCGGAAGTAGTTCCTTCTGC	0.577000													6	22					0.000157383	0.00196045	0.00307968	1	0
ALPK2	115701	broad.mit.edu	37	18	56202520	56202520	+	Silent	SNP	C	C	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr18:56202520C>T	ENST00000361673.3	-	5	5112	c.4899G>A	c.(4897-4899)gaG>gaA	p.E1633E		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1633							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TTTGAAGCACCTCTATTTTAG	0.448000													28	43					0	0	0.000720815	0	0
WIPI2	26100	broad.mit.edu	37	7	5270477	5270477	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr7:5270477G>C	ENST00000288828.4	+	13	1496	c.1264G>C	c.(1264-1266)Gac>Cac	p.D422H	WIPI2_ENST00000382384.2_Missense_Mutation_p.D393H|WIPI2_ENST00000401525.3_Missense_Mutation_p.D404H|WIPI2_ENST00000484262.1_Missense_Mutation_p.D352H|WIPI2_ENST00000404704.3_Missense_Mutation_p.D411H	NM_001033518.1|NM_001278299.1|NM_015610.3	NP_001028690.1|NP_001265228.1|NP_056425.1	Q9Y4P8	WIPI2_HUMAN	WD repeat domain, phosphoinositide interacting 2	422					autophagic vacuole assembly	cytosol|PAS complex|pre-autophagosomal structure membrane	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)	16		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0925)|OV - Ovarian serous cystadenocarcinoma(56;2.59e-14)		CTACACAGACGACCTGGGTGC	0.607000													11	39					0	0	0.000978159	0	0
NDST1	3340	broad.mit.edu	37	5	149900988	149900988	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr5:149900988G>T	ENST00000261797.6	+	2	674	c.172G>T	c.(172-174)Gac>Tac	p.D58Y	NDST1_ENST00000523767.1_Missense_Mutation_p.D58Y	NM_001543.4	NP_001534.1	P52848	NDST1_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	58	Heparan sulfate N-deacetylase 1.				heparan sulfate proteoglycan biosynthetic process|inflammatory response	Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(1)|large_intestine(6)|lung(10)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	34		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGACTGCGGGGACCCGCCGCC	0.652000													12	40					5.50884e-06	7.34085e-05	0.00136819	1	0
ZNF45	7596	broad.mit.edu	37	19	44423036	44423036	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr19:44423036C>G	ENST00000269973.5	-	9	1311	c.221G>C	c.(220-222)aGa>aCa	p.R74T	RP11-15A1.2_ENST00000586247.1_RNA|ZNF45_ENST00000589703.1_Missense_Mutation_p.R74T	NM_003425.3	NP_003416.1	Q02386	ZNF45_HUMAN	zinc finger protein 45	74	KRAB.				multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	17						GGAGTTATCTCTCTGGGTTGC	0.493000													11	36					0	0	0.00185496	0	0
EIF3G	8666	broad.mit.edu	37	19	10226237	10226237	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr19:10226237G>A	ENST00000253108.4	-	10	907	c.865C>T	c.(865-867)Cgc>Tgc	p.R289C		NM_003755.3	NP_003746.2	O75821	EIF3G_HUMAN	eukaryotic translation initiation factor 3, subunit G	289	RRM.					cytosol|eukaryotic translation initiation factor 3 complex|nucleus|perinuclear region of cytoplasm	nucleotide binding|protein binding|translation initiation factor activity			central_nervous_system(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(20;3.53e-09)|Epithelial(33;4.91e-06)|all cancers(31;1.1e-05)			TCCTCGCGGCGGTGGAAGCTG	0.642000													11	39					0	0	0.000978159	0	0
PPP6R2	9701	broad.mit.edu	37	22	50869699	50869699	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr22:50869699C>A	ENST00000359139.3	+	11	1617	c.1223C>A	c.(1222-1224)aCa>aAa	p.T408K	PPP6R2_ENST00000395744.3_Missense_Mutation_p.T408K|PPP6R2_ENST00000216061.5_Missense_Mutation_p.T408K|PPP6R2_ENST00000395741.3_Missense_Mutation_p.T409K	NM_001242898.1|NM_001242899.1|NM_001242900.1|NM_014678.4	NP_001229827.1|NP_001229828.1|NP_001229829.1|NP_055493.2	O75170	PP6R2_HUMAN	protein phosphatase 6, regulatory subunit 2	408						cytoplasm|intracellular membrane-bounded organelle	protein binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	22						GAGGAGAGGACAGAAGCCAGC	0.577000													14	75					1.05317e-09	1.47187e-08	0.00244969	1	0
LOC220729	220729	broad.mit.edu	37	3	197348646	197348646	+	RNA	SNP	T	T	C	rs138265355	by1000genomes	TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr3:197348646T>C	ENST00000418868.1	-	0	613					NR_003266.2																						TGGGCCTGCCTGCCCTTTCCA	0.532000													5	48					0	0	0.00116845	0	0
KRT23	25984	broad.mit.edu	37	17	39092616	39092616	+	Silent	SNP	G	G	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr17:39092616G>A	ENST00000209718.3	-	2	664	c.240C>T	c.(238-240)aaC>aaT	p.N80N	KRT23_ENST00000436344.3_Intron|AC004231.2_ENST00000418393.1_RNA	NM_015515.3	NP_056330.3	Q9C075	K1C23_HUMAN	keratin 23 (histone deacetylase inducible)	80	Coil 1A.|Rod.					intermediate filament	structural molecule activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21		Breast(137;0.000301)|Ovarian(249;0.15)				CCAGGCGGTCGTTGAGATTCT	0.612000													43	63					0	0	0.00361006	0	0
TSPAN11	441631	broad.mit.edu	37	12	31144797	31144797	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr12:31144797G>T	ENST00000261177.9	+	8	768	c.709G>T	c.(709-711)Ggg>Tgg	p.G237W	TSPAN11_ENST00000544427.1_Missense_Mutation_p.G227W|TSPAN11_ENST00000546076.1_Missense_Mutation_p.G237W|TSPAN11_ENST00000535215.1_Missense_Mutation_p.G166W	NM_001080509.2	NP_001073978.1	A1L157	TSN11_HUMAN	tetraspanin 11	237						integral to membrane				endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)	11	all_lung(12;3.11e-10)|Lung NSC(12;5.24e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					GCAGATCTGCGGGATGGTTCT	0.572000													5	111					3.59834e-05	0.000458188	0.00116845	1	0
NSUN3	63899	broad.mit.edu	37	3	93781971	93781971	+	Translation_Start_Site	SNP	A	A	G			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr3:93781971A>G	ENST00000314622.4	+	1	212	c.1A>G	c.(1-3)Atg>Gtg	p.M1V	DHFRL1_ENST00000394221.2_5'UTR|NSUN3_ENST00000485793.1_3'UTR	NM_022072.3	NP_071355.1	Q9H649	NSUN3_HUMAN	NOP2/Sun domain family, member 3	1							methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|skin(1)	18						CAGCGGGACAATGCTGACCCA	0.582000													71	93					0	0	0.00361006	0	0
FLG2	388698	broad.mit.edu	37	1	152325088	152325088	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr1:152325088C>T	ENST00000388718.5	-	3	5246	c.5174G>A	c.(5173-5175)gGa>gAa	p.G1725E	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1725							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGGCCAGATCCCCTTCTTCC	0.498000													55	154					0	0	0.00361006	0	0
SPTBN4	57731	broad.mit.edu	37	19	41003437	41003437	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr19:41003437C>T	ENST00000352632.3	+	7	796	c.710C>T	c.(709-711)gCc>gTc	p.A237V	SPTBN4_ENST00000598249.1_Missense_Mutation_p.A237V|SPTBN4_ENST00000595535.1_Missense_Mutation_p.A237V|SPTBN4_ENST00000338932.3_Missense_Mutation_p.A237V|SPTBN4_ENST00000344104.3_Missense_Mutation_p.A237V			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	237	Actin-binding.|CH 2.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AAGTCCAATGCCAACTACAAC	0.657000													13	62					0	0	0.00244969	0	0
SYNJ1	8867	broad.mit.edu	37	21	34037380	34037380	+	Splice_Site	SNP	C	C	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr21:34037380C>A	ENST00000382499.2	-	18	2263	c.2262_splice	c.e18-1	p.G755_splice	SYNJ1_ENST00000382491.3_Splice_Site_p.G711_splice|SYNJ1_ENST00000357345.3_Splice_Site_p.G716_splice|SYNJ1_ENST00000433931.2_Splice_Site_p.G755_splice|SYNJ1_ENST00000322229.7_Splice_Site_p.G716_splice	NM_203446.2	NP_982271.2	O43426	SYNJ1_HUMAN	synaptojanin 1	716	Catalytic (Potential).						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						TAGCATCCTTCCCTGAAAGCA	0.353000													12	15					2.27111e-07	3.09844e-06	0.00136819	1	0
RPA2	6118	broad.mit.edu	37	1	28233446	28233446	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr1:28233446T>C	ENST00000373912.3	-	4	625	c.326A>G	c.(325-327)gAc>gGc	p.D109G	RPA2_ENST00000373909.3_Missense_Mutation_p.D117G|RPA2_ENST00000313433.7_Missense_Mutation_p.D197G	NM_002946.3	NP_002937.1	P15927	RFA2_HUMAN	replication protein A2, 32kDa	109	Asp/Glu-rich (acidic).				cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|regulation of double-strand break repair via homologous recombination|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor A complex|PML body	protein phosphatase binding|single-stranded DNA binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|prostate(3)|skin(1)	11		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00588)|all_lung(284;0.00645)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0429)|OV - Ovarian serous cystadenocarcinoma(117;3.62e-24)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;1.75e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00294)|STAD - Stomach adenocarcinoma(196;0.00308)|BRCA - Breast invasive adenocarcinoma(304;0.00613)|READ - Rectum adenocarcinoma(331;0.0649)		TACATCTGTGTCAACCCACTG	0.393000								Direct reversal of damage;Nucleotide excision repair (NER)					4	26					0	0	0.00024832	0	0
ZNF45	7596	broad.mit.edu	37	19	44419091	44419091	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr19:44419091C>T	ENST00000269973.5	-	10	1587	c.497G>A	c.(496-498)gGa>gAa	p.G166E	RP11-15A1.2_ENST00000586247.1_RNA|ZNF45_ENST00000589703.1_Missense_Mutation_p.G166E	NM_003425.3	NP_003416.1	Q02386	ZNF45_HUMAN	zinc finger protein 45	166					multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	17						ACAATGTTCTCCTTTGTAGGG	0.398000													18	49					0	0	0.000958276	0	0
DSCAM	1826	broad.mit.edu	37	21	41455872	41455872	+	Silent	SNP	A	A	C			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr21:41455872A>C	ENST00000400454.1	-	24	4671	c.4194T>G	c.(4192-4194)tcT>tcG	p.S1398S		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1398	Fibronectin type-III 5.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CAGGGAGCCAAGAAAGGGTGA	0.443000													9	35					0	0	0.000673444	0	0
CYP4Z2P	163720	broad.mit.edu	37	1	47325354	47325354	+	RNA	SNP	G	G	A	rs4660360	by1000genomes	TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr1:47325354G>A	ENST00000505841.1	-	0	1175					NR_002788.2																						CATCTGGAAAGGTAATGGGTT	0.438000													7	66					0	0	0.000673444	0	0
PCNX	22990	broad.mit.edu	37	14	71572021	71572021	+	Silent	SNP	G	G	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr14:71572021G>T	ENST00000304743.2	+	33	6611	c.6165G>T	c.(6163-6165)ggG>ggT	p.G2055G	PCNX_ENST00000556272.1_3'UTR|PCNX_ENST00000238570.5_Silent_p.G1983G|PCNX_ENST00000439984.3_Silent_p.G1944G	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	2055						integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		CTGGAGGTGGGACTTCCTGCA	0.493000													23	17					4.54149e-19	6.50568e-18	0.00229938	1	0
CEP350	9857	broad.mit.edu	37	1	179955328	179955329	+	Frame_Shift_Ins	INS	-	-	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr1:179955328_179955329insA	ENST00000367607.3	+	2	430_431	c.12_13insA	c.(10-15)agaatcfs	p.I5fs		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	5						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						TGAGGAGCAGCAAATCAAAAGA	0.322													2	4	---	---	---	---					
DZIP1L	199221	broad.mit.edu	37	3	137783520	137783521	+	Frame_Shift_Ins	INS	-	-	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr3:137783520_137783521insA	ENST00000327532.2	-	15	2453_2454	c.2091_2092insT	c.(2089-2094)tttgccfs	p.A698fs		NM_173543.2	NP_775814.2	Q8IYY4	DZI1L_HUMAN	DAZ interacting zinc finger protein 1-like	698						intracellular	zinc ion binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(2)|prostate(1)|skin(1)	35						GCATTGGGCATAAAAAACAGAC	0.515													78	295	---	---	---	---					
SNAPC4	6621	broad.mit.edu	37	9	139277995	139277997	+	In_Frame_Del	DEL	GCT	GCT	-	rs34222232		TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr9:139277995_139277997delGCT	ENST00000298532.2	-	15	1992_1994	c.1624_1626delAGC	c.(1624-1626)del	p.S542del		NM_003086.2	NP_003077.2	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex, polypeptide 4, 190kDa	542					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity	p.S542delS(2)		biliary_tract(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	33		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		CGTCCTCCTCgctgctgctgctg	0.690													3	3	---	---	---	---					
CD44	960	broad.mit.edu	37	11	35222633	35222634	+	Frame_Shift_Ins	INS	-	-	ACCAC			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr11:35222633_35222634insACCAC	ENST00000428726.2	+	8	1050_1051	c.927_928insACCAC	c.(925-930)tcccacfs	p.H310fs	CD44_ENST00000415148.2_Frame_Shift_Ins_p.H267fs|CD44_ENST00000360158.4_Intron|CD44_ENST00000352818.4_Intron|CD44_ENST00000278386.6_Intron|CD44_ENST00000526669.2_Intron|CD44_ENST00000263398.6_Intron|CD44_ENST00000449691.2_Frame_Shift_Ins_p.H310fs|CD44_ENST00000437706.2_Frame_Shift_Ins_p.H310fs|CD44_ENST00000434472.2_Intron|CD44_ENST00000433892.2_Intron|CD44_ENST00000433354.2_Frame_Shift_Ins_p.H310fs	NM_000610.3	NP_000601.3	P16070	CD44_HUMAN	CD44 molecule (Indian blood group)	310	Stem.				cell-cell adhesion|cell-matrix adhesion|interferon-gamma-mediated signaling pathway|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation	cell surface|Golgi apparatus|integral to plasma membrane	collagen binding|hyaluronic acid binding|receptor activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(13)|pancreas(1)|skin(1)	23	all_cancers(35;0.212)|all_lung(20;0.0874)|all_epithelial(35;0.112)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.00731)		Hyaluronidase(DB00070)	TCACAGTTTCAACCACACCACG	0.455													12	105	---	---	---	---					
TRAV24	28659	broad.mit.edu	37	14	22573825	22573826	+	RNA	INS	-	-	A	rs33991650	by1000genomes	TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr14:22573825_22573826insA	ENST00000390453.1	+	0	55																											GACTCTTTTTTAAAAAAACAGG	0.450													7	9	---	---	---	---					
HERC2P2	400322	broad.mit.edu	37	15	23331163	23331163	+	RNA	DEL	A	A	-			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr15:23331163delA	ENST00000560464.1	-	0	908																											AATAAATACTAAAAAAAAAAA	0.368													3	6	---	---	---	---