Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OR5K4	403278	broad.mit.edu	37	3	98072851	98072851	+	Missense_Mutation	SNP	G	G	A	rs139874815	byFrequency	TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr3:98072851G>A	ENST00000354924.2	+	1	154	c.154G>A	c.(154-156)Gag>Aag	p.E52K	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005517.1	NP_001005517.1	A6NMS3	OR5K4_HUMAN	olfactory receptor, family 5, subfamily K, member 4	52					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(13)|upper_aerodigestive_tract(1)	21						AATTTATGTAGAGCGTCGTCT	0.463000													17	227					0	0	0.028581	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39140536	39140536	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr9:39140536A>T	ENST00000297668.6	-	12	1929	c.1856T>A	c.(1855-1857)cTt>cAt	p.L619H	CNTNAP3_ENST00000358144.2_Missense_Mutation_p.L531H|CNTNAP3_ENST00000323947.7_Missense_Mutation_p.L526H|CNTNAP3_ENST00000377656.2_Missense_Mutation_p.L619H|CNTNAP3_ENST00000377659.1_Missense_Mutation_p.L619H	NM_033655.3	NP_387504.2	Q9BZ76	CNTP3_HUMAN	contactin associated protein-like 3	619	Fibrinogen C-terminal.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	24				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GCAGTACACAAGAAATGGTCC	0.438000													6	61					0	0	0.029380	0	0
RBM47	54502	broad.mit.edu	37	4	40440107	40440107	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr4:40440107C>G	ENST00000319592.4	-	4	1513	c.804G>C	c.(802-804)caG>caC	p.Q268H	RBM47_ENST00000515809.1_Intron|RBM47_ENST00000295971.7_Missense_Mutation_p.Q268H|RBM47_ENST00000381795.6_Missense_Mutation_p.Q268H|RBM47_ENST00000514014.1_Missense_Mutation_p.Q230H|RBM47_ENST00000381793.2_Missense_Mutation_p.Q268H			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	268	RRM 3.					nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						CGGGGTTGAACTGGCCGAAGC	0.592000													5	75					0	0	0.021553	0	0
ATG4A	115201	broad.mit.edu	37	X	107381181	107381181	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chrX:107381181G>A	ENST00000372232.3	+	8	854	c.695G>A	c.(694-696)gGc>gAc	p.G232D	ATG4A_ENST00000545696.1_Intron|ATG4A_ENST00000345734.3_Intron|ATG4A_ENST00000372254.3_Missense_Mutation_p.G208D	NM_052936.3	NP_443168.2	Q8WYN0	ATG4A_HUMAN	autophagy related 4A, cysteine peptidase	232					autophagy|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity	p.G232D(2)		endometrium(3)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)	11						CTTCGCCTGGGCATAAACCAA	0.522000													4	130					0	0	0.014758	0	0
NANOS3	342977	broad.mit.edu	37	19	13988290	13988290	+	Silent	SNP	G	G	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr19:13988290G>T	ENST00000397555.2	+	2	171	c.171G>T	c.(169-171)ctG>ctT	p.L57L	NANOS3_ENST00000591727.1_Intron|NANOS3_ENST00000591161.1_Intron|NANOS3_ENST00000339133.5_Silent_p.L76L	NM_001098622.2	NP_001092092.1	P60323	NANO3_HUMAN	nanos homolog 3 (Drosophila)	57					anti-apoptosis|germ cell development|multicellular organismal development|oogenesis|regulation of cell cycle|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|nucleus|stress granule	RNA binding|zinc ion binding			breast(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	7			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			CCGAACGCCTGTGCTCTTTCT	0.657000													7	31					0.00307968	0.00326823	0.003080	1	0
WSB1	26118	broad.mit.edu	37	17	25639344	25639344	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr17:25639344G>T	ENST00000262394.2	+	9	1531	c.1215G>T	c.(1213-1215)caG>caT	p.Q405H	WSB1_ENST00000348811.2_Missense_Mutation_p.Q259H	NM_015626.8	NP_056441.6	Q9Y6I7	WSB1_HUMAN	WD repeat and SOCS box containing 1	405	SOCS box.				intracellular signal transduction	intracellular	protein binding			lung(3)	3	all_cancers(1;2e-13)|all_epithelial(1;4.8e-15)|Lung NSC(42;0.00152)		BRCA - Breast invasive adenocarcinoma(3;0.0152)	UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		AAGAAGTTCAGGAGCTGCCGA	0.478000													24	339					6.07407e-21	6.64951e-21	0.034045	1	0
LOC101927209	101927209	broad.mit.edu	37	1	142713773	142713773	+	RNA	SNP	C	C	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr1:142713773C>G	ENST00000369381.2	-	0	832																											TCTTTTTCCACATTGTCATTT	0.284000													5	58					0	0	0.014758	0	0
MUC5B	727897	broad.mit.edu	37	11	1264737	1264737	+	Silent	SNP	G	G	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr11:1264737G>A	ENST00000447027.1	+	31	6694	c.6636G>A	c.(6634-6636)acG>acA	p.T2212T	MUC5B_ENST00000529681.1_Silent_p.T2209T|RP11-532E4.2_ENST00000532061.2_RNA			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	2209	7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GTCCCCACACGGTGCGCACAG	0.662000													18	46					0	0	0.016522	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72013863	72013863	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr12:72013863G>A	ENST00000378743.3	-	26	5250	c.4892C>T	c.(4891-4893)tCa>tTa	p.S1631L		NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	1631					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						AATAGGACATGATTCCAATAA	0.353000													13	29					0	0	0.013537	0	0
GRIP1	23426	broad.mit.edu	37	12	66786136	66786136	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr12:66786136C>G	ENST00000359742.4	-	19	2656	c.2416G>C	c.(2416-2418)Gtg>Ctg	p.V806L	GRIP1_ENST00000398016.3_Missense_Mutation_p.V754L|GRIP1_ENST00000286445.7_Missense_Mutation_p.V806L			Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	806					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			NS(3)|breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(19)|ovary(2)|prostate(2)|skin(1)	50			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		CATGAATCCACAGCACTGTCC	0.547000													17	164					0	0	0.006122	0	0
OTOGL	283310	broad.mit.edu	37	12	80750654	80750654	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr12:80750654A>C	ENST00000458043.2	+	48	5958	c.5952A>C	c.(5950-5952)caA>caC	p.Q1984H	OTOGL_ENST00000547103.1_Missense_Mutation_p.Q1972H|OTOGL_ENST00000546620.1_Missense_Mutation_p.Q3H	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TCATGATTCAAGTTCGACAGG	0.348000													5	39					0	0	0.021553	0	0
HNRNPU	3192	broad.mit.edu	37	1	245018852	245018852	+	Silent	SNP	G	G	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr1:245018852G>A	ENST00000444376.2	-	12	2403	c.2169C>T	c.(2167-2169)ggC>ggT	p.G723G	HNRNPU_ENST00000283179.9_Silent_p.G742G	NM_004501.3|NM_031844.2	NP_004492.2|NP_114032.2	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	742	Gly-rich.|RNA-binding RGG-box.				CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding			NS(1)|endometrium(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			TTCCTCCACCGCCACCACCTC	0.502000													5	91					0	0	0.021553	0	0
INHBC	3626	broad.mit.edu	37	12	57828826	57828826	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr12:57828826G>A	ENST00000309668.2	+	1	284	c.157G>A	c.(157-159)Gac>Aac	p.D53N	INHBC_ENST00000550133.1_Missense_Mutation_p.D53N	NM_005538.2	NP_005529.1	P55103	INHBC_HUMAN	inhibin, beta C	53					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding			breast(2)|endometrium(1)|large_intestine(6)|liver(2)|lung(4)|prostate(1)	16						AAGCATCTTGGACAAGCTGCA	0.632000													34	56					0	0	0.021022	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64589985	64589985	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr3:64589985T>C	ENST00000498707.1	-	24	3839	c.3497A>G	c.(3496-3498)cAt>cGt	p.H1166R	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.H1138R	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1166	TSP type-1 6.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		TGGGGGAGGATGACATGATGG	0.473000													29	628					0	0	0.017118	0	0
NUP214	8021	broad.mit.edu	37	9	134038526	134038526	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr9:134038526T>C	ENST00000359428.5	+	19	2833	c.2689T>C	c.(2689-2691)Tcc>Ccc	p.S897P	RP11-544A12.4_ENST00000590461.1_RNA|RP11-544A12.4_ENST00000588378.1_RNA|RP11-544A12.4_ENST00000586662.1_RNA|RP11-544A12.4_ENST00000587408.1_RNA|RP11-544A12.4_ENST00000587264.1_RNA|RP11-544A12.4_ENST00000417798.2_RNA|RP11-544A12.4_ENST00000589540.1_RNA|NUP214_ENST00000411637.2_Missense_Mutation_p.S887P|NUP214_ENST00000451030.1_Missense_Mutation_p.S898P|RP11-544A12.4_ENST00000415391.2_RNA|RP11-544A12.4_ENST00000589667.1_RNA|RP11-544A12.4_ENST00000586290.1_RNA|RP11-544A12.4_ENST00000589128.1_RNA			P35658	NU214_HUMAN	nucleoporin 214kDa	897	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		GTGGAGCCTGTCCTCGGCTGT	0.488000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								5	65					0	0	0.014758	0	0
SERPINI1	5274	broad.mit.edu	37	3	167507139	167507139	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr3:167507139T>G	ENST00000295777.5	+	2	654	c.223T>G	c.(223-225)Tca>Gca	p.S75A	SERPINI1_ENST00000446050.2_Missense_Mutation_p.S75A	NM_005025.4	NP_005016.1	Q99574	NEUS_HUMAN	serpin peptidase inhibitor, clade I (neuroserpin), member 1	75					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(7)|skin(2)	20						AATCCGCCACTCAATGGGATA	0.383000													8	29					0	0	0.006214	0	0
PIGR	5284	broad.mit.edu	37	1	207110861	207110861	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr1:207110861G>C	ENST00000356495.4	-	4	807	c.624C>G	c.(622-624)aaC>aaG	p.N208K		NM_002644.3	NP_002635.2	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor	208	Ig-like V-type 2.			NQ -> DE (in Ref. 6; AA sequence and 7; AA sequence).		extracellular region|integral to plasma membrane	protein binding			central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						GCCTGAGTTGGTTGATGACAA	0.483000													4	51					0	0	0.009096	0	0
MYO5C	55930	broad.mit.edu	37	15	52567822	52567822	+	Silent	SNP	G	G	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr15:52567822G>A	ENST00000261839.7	-	5	704	c.543C>T	c.(541-543)gtC>gtT	p.V181V	MYO5C_ENST00000541028.1_5'UTR|MYO5C_ENST00000443683.2_Silent_p.V124V	NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	181	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		CCGATTTGCTGACGGTGGCAA	0.542000													7	95					0	0	0.029380	0	0
PCSK5	5125	broad.mit.edu	37	9	78907175	78907175	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr9:78907175G>A	ENST00000545128.1	+	25	3707	c.3169G>A	c.(3169-3171)Gct>Act	p.A1057T		NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	757					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						TACATCTTGCGCTATGGGGTA	0.363000													10	100					0	0	0.020292	0	0
NIPBL	25836	broad.mit.edu	37	5	36962278	36962278	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr5:36962278A>G	ENST00000282516.8	+	6	1011	c.512A>G	c.(511-513)aAt>aGt	p.N171S	NIPBL_ENST00000448238.2_Missense_Mutation_p.N171S|NIPBL_ENST00000504430.1_3'UTR	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	171					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			CCACAGCAAAATAGCCCAGTG	0.433000													8	176					0	0	0.004482	0	0
HNF4G	3174	broad.mit.edu	37	8	76465282	76465282	+	Silent	SNP	A	A	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr8:76465282A>C	ENST00000396423.2	+	5	589	c.465A>C	c.(463-465)tcA>tcC	p.S155S	HNF4G_ENST00000354370.1_Silent_p.S118S	NM_004133.4	NP_004124.4	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	118					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	37	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			ACTAGATCTCAGTCTCAAGCC	0.353000													3	19					0	0	0.004672	0	0
UGT1A4	54657	broad.mit.edu	37	2	234627881	234627881	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr2:234627881A>G	ENST00000373409.3	+	1	458	c.415A>G	c.(415-417)Agg>Ggg	p.R139G	UGT1A8_ENST00000373450.4_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A6_ENST00000480628.1_Intron	NM_007120.2	NP_009051.1														autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|skin(2)|urinary_tract(1)	26		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;3.49e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000504)|Lung(119;0.0026)|LUSC - Lung squamous cell carcinoma(224;0.00624)		GGCCCTGATCAGGCACCTGAA	0.453000													4	191					0	0	0.014758	0	0
LRRN4	164312	broad.mit.edu	37	20	6022584	6022584	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr20:6022584G>C	ENST00000378858.4	-	5	1531	c.1307C>G	c.(1306-1308)tCt>tGt	p.S436C		NM_152611.4	NP_689824.2	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4	436						integral to membrane				breast(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	27						ACCTGCTACAGAGTTGGTCGT	0.637000													6	72					0	0	0.029380	0	0
VGF	7425	broad.mit.edu	37	7	100807585	100807585	+	Silent	SNP	C	C	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr7:100807585C>G	ENST00000249330.2	-	2	779	c.540G>C	c.(538-540)acG>acC	p.T180T	VGF_ENST00000445482.2_Silent_p.T180T	NM_003378.3	NP_003369.2	O15240	VGF_HUMAN	VGF nerve growth factor inducible	180					response to cAMP	extracellular space|transport vesicle	growth factor activity			cervix(1)|large_intestine(1)|lung(4)|prostate(2)|skin(1)	9	Lung NSC(181;0.168)|all_lung(186;0.215)					CTGCTGCCGCCGTCTCCTGCT	0.667000													3	53					0	0	0.009096	0	0
ZNF22	7570	broad.mit.edu	37	10	45498982	45498982	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr10:45498982A>G	ENST00000298299.3	+	2	759	c.166A>G	c.(166-168)Aaa>Gaa	p.K56E	CEP164P1_ENST00000456938.2_RNA	NM_006963.4	NP_008894.2	P17026	ZNF22_HUMAN	zinc finger protein 22	56					odontogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|plasma membrane	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(2)|lung(2)	8		Prostate(175;0.0352)|all_neural(218;0.202)				CAAACCCTATAAATGTACTGA	0.433000													9	55					0	0	0.006214	0	0
SLC17A6	57084	broad.mit.edu	37	11	22381014	22381014	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr11:22381014G>T	ENST00000263160.3	+	4	951	c.514G>T	c.(514-516)Gca>Tca	p.A172S		NM_020346.2	NP_065079.1	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 6	172					sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)	50						AATTCCATCAGCAGCCAGAGT	0.398000													7	59					0.00307968	0.00326823	0.003080	1	0
U66061.31	0	broad.mit.edu	37	7	142423696	142423696	+	RNA	SNP	T	T	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr7:142423696T>G	ENST00000506718.1	+	0	704																											ATCCACAGTGTTGCACAGCCA	0.527000													3	28					0	0	0.004672	0	0
PEX7	5191	broad.mit.edu	37	6	137219309	137219309	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr6:137219309T>A	ENST00000318471.4	+	9	914	c.833T>A	c.(832-834)cTt>cAt	p.L278H	PEX7_ENST00000541292.1_3'UTR	NM_000288.3	NP_000279.1	O00628	PEX7_HUMAN	peroxisomal biogenesis factor 7	278					ether lipid biosynthetic process|protein import into peroxisome matrix	peroxisome	peroxisome matrix targeting signal-2 binding			lung(7)|prostate(1)	8	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000257)|OV - Ovarian serous cystadenocarcinoma(155;0.00492)		CCTGACTCTCTTCTTGAAACA	0.338000													4	52					0	0	0.014758	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102312676	102312676	+	RNA	SNP	T	T	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr15:102312676T>C	ENST00000561463.1	+	0	14044																											AGGAGGTCCATAAGGCCACTC	0.562000													5	57					0	0	0.021553	0	0
NOL4	8715	broad.mit.edu	37	18	31537451	31537451	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr18:31537451A>C	ENST00000261592.5	-	8	1564	c.1267T>G	c.(1267-1269)Ttg>Gtg	p.L423V	NOL4_ENST00000538587.1_Missense_Mutation_p.L349V|NOL4_ENST00000535384.1_Missense_Mutation_p.L138V|NOL4_ENST00000589544.1_Intron|NOL4_ENST00000535475.1_Intron|NOL4_ENST00000269185.4_Intron	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	423						nucleolus	RNA binding	p.L423L(1)		NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						ATTCGGTCCAAGTTTTCATCT	0.493000													7	26					0	0	0.029380	0	0
MTRR	4552	broad.mit.edu	37	5	7873569	7873569	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr5:7873569G>C	ENST00000264668.2	+	3	324	c.294G>C	c.(292-294)aaG>aaC	p.K98N	MTRR_ENST00000440940.2_Missense_Mutation_p.K71N|MTRR_ENST00000502509.1_Intron|MTRR_ENST00000341013.6_Intron	NM_002454.2|NM_024010.2	NP_002445.2|NP_076915.2	Q9UBK8	MTRR_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	98	Flavodoxin-like.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(14)|ovary(1)|prostate(3)|stomach(1)	31					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	CAGCCCGCAAGTTTGTTAAGG	0.463000													4	89					0	0	0.009096	0	0
AKAP6	9472	broad.mit.edu	37	14	33292622	33292622	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr14:33292622A>C	ENST00000280979.4	+	13	5773	c.5603A>C	c.(5602-5604)cAt>cCt	p.H1868P	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1868					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AATTCATCTCATACCCATGAG	0.358000													4	30					0	0	0.009096	0	0
SNHG14	104472715	broad.mit.edu	37	15	25492431	25492431	+	RNA	SNP	C	C	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr15:25492431C>G	ENST00000453082.2	+	0	2892					NR_003343.1																						CTGCACTGAGCTGTGGTGAGC	0.592000													11	106					0	0	0.008291	0	0
OR4M1	441670	broad.mit.edu	37	14	20248923	20248923	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr14:20248923T>A	ENST00000315957.4	+	1	523	c.442T>A	c.(442-444)Tcc>Acc	p.S148T		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	148					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GGTGGCTCTCTCCTGGATGGG	0.502000													12	185					0	0	0.013537	0	0
USP44	84101	broad.mit.edu	37	12	95926931	95926931	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr12:95926931G>C	ENST00000258499.3	-	2	1390	c.1102C>G	c.(1102-1104)Ctt>Gtt	p.L368V	USP44_ENST00000537435.2_Missense_Mutation_p.L368V|USP44_ENST00000393091.2_Missense_Mutation_p.L368V|USP44_ENST00000552440.1_Missense_Mutation_p.L368V	NM_001278393.1|NM_032147.2	NP_001265322.1|NP_115523.2	Q9H0E7	UBP44_HUMAN	ubiquitin specific peptidase 44	368					anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(5)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	36						GGCTGAATAAGTTCCATCTTT	0.418000													5	79					0	0	0.014758	0	0
CCNB3	85417	broad.mit.edu	37	X	50094673	50094673	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chrX:50094673G>C	ENST00000376042.1	+	13	4457	c.4159G>C	c.(4159-4161)Gat>Cat	p.D1387H	CCNB3_ENST00000376038.1_Missense_Mutation_p.D283H|CCNB3_ENST00000348603.2_Missense_Mutation_p.D283H|CCNB3_ENST00000276014.7_Missense_Mutation_p.D1387H			Q8WWL7	CCNB3_HUMAN	cyclin B3	1387					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					TTTGAACTGTGATTGTGAGGC	0.458000													4	22					0	0	0.014758	0	0
TFEB	7942	broad.mit.edu	37	6	41652468	41652468	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr6:41652468C>T	ENST00000230323.4	-	10	1601	c.1300G>A	c.(1300-1302)Gac>Aac	p.D434N	TFEB_ENST00000420312.1_Missense_Mutation_p.D349N|TFEB_ENST00000358871.2_Missense_Mutation_p.D448N|TFEB_ENST00000403298.4_Missense_Mutation_p.D434N|TFEB_ENST00000373033.1_Missense_Mutation_p.D434N	NM_001271945.1|NM_007162.2	NP_001258874.1|NP_009093.1	P19484	TFEB_HUMAN	transcription factor EB	434				EPLAPGHGSPFPSLSKKDLDLMLLDDSLLPLASDPLLSTMS PEASKASSRRSSFSMEEGDVL -> DRN (in Ref. 1).	embryonic placenta development|humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	11	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;7.61e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			AGCATGAGGTCCAGATCCTTC	0.677000			T	ALPHA	renal (childhood epithelioid)								5	71					0	0	0.014758	0	0
CFHR4	10877	broad.mit.edu	37	1	196884213	196884213	+	Silent	SNP	T	T	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr1:196884213T>A	ENST00000367416.2	+	9	1619	c.1482T>A	c.(1480-1482)ggT>ggA	p.G494G	CFHR4_ENST00000367418.1_Silent_p.G248G|CFHR2_ENST00000367421.3_Intron|CFHR4_ENST00000251424.4_Silent_p.G248G	NM_001201550.2|NM_001201551.1	NP_001188479.1|NP_001188480.1			complement factor H-related 4											NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	36						AACTTCAGGGTTCTAATTATG	0.398000													9	165					0	0	0.004482	0	0
ELTD1	64123	broad.mit.edu	37	1	79383605	79383605	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr1:79383605T>C	ENST00000370742.3	-	11	1655	c.1592A>G	c.(1591-1593)aAg>aGg	p.K531R		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	531					neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		ATAAAAATTCTTGTGCAAAAA	0.393000													10	102					0	0	0.006214	0	0
ADCY8	114	broad.mit.edu	37	8	131916183	131916183	+	Silent	SNP	G	G	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr8:131916183G>A	ENST00000286355.5	-	7	3838	c.1746C>T	c.(1744-1746)atC>atT	p.I582I	ADCY8_ENST00000377928.3_Silent_p.I582I	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	582					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AGTAAGTTTCGATATTATGCT	0.478000										HNSCC(32;0.087)			11	122					0	0	0.013537	0	0
HLA-DRA	3122	broad.mit.edu	37	6	32411551	32411551	+	Missense_Mutation	SNP	C	C	T	rs58547911		TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr6:32411551C>T	ENST00000395388.2	+	4	738	c.629C>T	c.(628-630)cCt>cTt	p.P210L	HLA-DRA_ENST00000374982.5_Missense_Mutation_p.P185L	NM_019111.4	NP_061984.2	P01903	DRA_HUMAN	major histocompatibility complex, class II, DR alpha	210	Connecting peptide.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|Golgi apparatus|integral to plasma membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity	p.P210H(1)		NS(1)|breast(1)|large_intestine(6)|lung(5)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	19						GCTCCAAGCCCTCTCCCAGAG	0.488000									T-cell Lymphoma, (Cutaneous) , Familial Clustering of;Kaposi Sarcoma, Familial Clustering of				12	163					0	0	0.020292	0	0
OR2J2	26707	broad.mit.edu	37	6	29141880	29141880	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr6:29141880C>G	ENST00000377167.2	+	1	570	c.468C>G	c.(466-468)atC>atG	p.I156M		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	156					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						GTTTTACTATCTCAGCACTTC	0.458000													15	219					0	0	0.006122	0	0
LMAN2L	81562	broad.mit.edu	37	2	97377656	97377656	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr2:97377656C>T	ENST00000264963.4	-	5	636	c.614G>A	c.(613-615)cGc>cAc	p.R205H	LMAN2L_ENST00000426463.2_Missense_Mutation_p.R71H|LMAN2L_ENST00000537039.1_Missense_Mutation_p.R67H|LMAN2L_ENST00000534882.1_Missense_Mutation_p.R60H|LMAN2L_ENST00000377079.4_Missense_Mutation_p.R216H	NM_030805.3	NP_110432.1	Q9H0V9	LMA2L_HUMAN	lectin, mannose-binding 2-like	205	L-type lectin-like.				ER to Golgi vesicle-mediated transport|protein folding|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi membrane|integral to membrane	mannose binding|metal ion binding			NS(1)|breast(1)|endometrium(1)|lung(2)|skin(1)|urinary_tract(1)	7						ATGAAGATTGCGGACAATGGC	0.562000													4	69					0	0	0.014758	0	0
C16orf58	64755	broad.mit.edu	37	16	31504903	31504903	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr16:31504903C>T	ENST00000430477.2	-	7	874	c.553G>A	c.(553-555)Ggg>Agg	p.G185R	C16orf58_ENST00000327237.2_Intron|C16orf58_ENST00000570164.1_Intron|C16orf58_ENST00000567994.1_Intron			Q96GQ5	CP058_HUMAN	chromosome 16 open reading frame 58	0			Y -> C (in dbSNP:rs17855405).			integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)	14						ACACAGGACCCGAGACCAGGG	0.617000													3	41					0	0	0.004672	0	0
TMEM88	92162	broad.mit.edu	37	17	7758463	7758463	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr17:7758463G>C	ENST00000301599.6	+	1	81	c.71G>C	c.(70-72)tGt>tCt	p.C24S	TMEM88_ENST00000574668.1_Missense_Mutation_p.C24S	NM_203411.1	NP_981956.1	Q6PEY1	TMM88_HUMAN	transmembrane protein 88	24						integral to membrane				lung(1)	1		all_cancers(10;0.00528)|Prostate(122;0.202)				CCCCTGGACTGTTGGGCCTGC	0.672000													5	21					0	0	0.021553	0	0
MB21D2	151963	broad.mit.edu	37	3	192517116	192517116	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr3:192517116A>C	ENST00000392452.2	-	2	855	c.535T>G	c.(535-537)Ttc>Gtc	p.F179V		NM_178496.3	NP_848591.2	Q8IYB1	M21D2_HUMAN	Mab-21 domain containing 2	179										endometrium(3)|kidney(1)|large_intestine(4)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	31						GTAGGTGAGAAGAAGTAGTTG	0.463000													4	71					0	0	0.009096	0	0
SERPINB7	8710	broad.mit.edu	37	18	61471766	61471766	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr18:61471766A>C	ENST00000398019.2	+	8	1365	c.1040A>C	c.(1039-1041)aAg>aCg	p.K347T	SERPINB7_ENST00000336429.2_Missense_Mutation_p.K347T|SERPINB7_ENST00000546027.1_Missense_Mutation_p.K347T|SERPINB7_ENST00000540675.1_Missense_Mutation_p.K330T	NM_003784.3	NP_003775.1	O75635	SPB7_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 7	347		Reactive bond (By similarity).			regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	27		Esophageal squamous(42;0.129)				ATTGTAGAAAAGCAACTCCCT	0.453000													7	28					0	0	0.029380	0	0
WDR43	23160	broad.mit.edu	37	2	29152468	29152468	+	Silent	SNP	A	A	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr2:29152468A>T	ENST00000407426.3	+	11	1385	c.1329A>T	c.(1327-1329)ggA>ggT	p.G443G		NM_015131.1	NP_055946.1	Q15061	WDR43_HUMAN	WD repeat domain 43	443						nucleolus				breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	20	Acute lymphoblastic leukemia(172;0.155)					AACGTCTGGGAGCAATGGATA	0.363000													5	27					0	0	0.014758	0	0
PRICKLE2	166336	broad.mit.edu	37	3	64139008	64139008	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr3:64139008G>A	ENST00000295902.6	-	6	1222	c.637C>T	c.(637-639)Cga>Tga	p.R213*	PRICKLE2_ENST00000564377.1_Nonsense_Mutation_p.R269*	NM_198859.3	NP_942559.1	Q7Z3G6	PRIC2_HUMAN	prickle homolog 2 (Drosophila)	213	LIM zinc-binding 2.					cytoplasm|nuclear membrane	zinc ion binding			breast(2)|endometrium(1)|large_intestine(9)|liver(1)|lung(10)|ovary(4)|prostate(2)|skin(2)|stomach(1)	32		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		TGCCAGTGTCGCCCCTCAGCT	0.498000													15	153					0	0	0.006122	0	0
KIAA1683	80726	broad.mit.edu	37	19	18377313	18377313	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr19:18377313A>G	ENST00000392413.3	-	3	1252	c.1037T>C	c.(1036-1038)gTc>gCc	p.V346A	KIAA1683_ENST00000600359.2_Missense_Mutation_p.V300A|KIAA1683_ENST00000600328.2_Missense_Mutation_p.V346A	NM_001145304.1|NM_001145305.1|NM_025249.3	NP_001138776.1|NP_001138777.1|NP_079525.1	Q9H0B3	K1683_HUMAN	KIAA1683	346	Thr-rich.					mitochondrion				breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						GGTCACGGAGACCACTGGATA	0.557000													7	81					0	0	0.003080	0	0
PGK2	5232	broad.mit.edu	37	6	49754266	49754266	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr6:49754266A>C	ENST00000304801.3	-	1	787	c.635T>G	c.(634-636)cTt>cGt	p.L212R		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	212					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					GGCTCCACCAAGTATAGCCAG	0.423000													6	98					0	0	0.021553	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713774	142713774	+	RNA	SNP	A	A	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr1:142713774A>G	ENST00000369381.2	-	0	831																											CTTTTTCCACATTGTCATTTT	0.284000													5	59					0	0	0.014758	0	0
UBQLN3	50613	broad.mit.edu	37	11	5529328	5529328	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr11:5529328C>G	ENST00000311659.4	-	2	1608	c.1461G>C	c.(1459-1461)agG>agC	p.R487S	HBG2_ENST00000380259.2_Intron	NM_017481.2	NP_059509.1	Q9H347	UBQL3_HUMAN	ubiquilin 3	487										NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|prostate(1)|skin(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGCCATCTGGCCTCAGAGATC	0.572000													17	78					0	0	0.033300	0	0
TRIM22	10346	broad.mit.edu	37	11	5717766	5717766	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr11:5717766A>C	ENST00000379965.3	+	2	581	c.304A>C	c.(304-306)Aaa>Caa	p.K102Q	TRIM5_ENST00000380027.1_Intron	NM_001199573.1|NM_006074.4	NP_001186502.1|NP_006065.2	Q8IYM9	TRI22_HUMAN	tripartite motif containing 22	102					immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			kidney(3)|large_intestine(8)|lung(9)|prostate(1)|stomach(2)	23		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		GCACCATGGAAAAAAACTCCA	0.478000													8	58					0	0	0.003080	0	0
MYH15	22989	broad.mit.edu	37	3	108158593	108158593	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr3:108158593T>G	ENST00000273353.3	-	25	3182	c.3126A>C	c.(3124-3126)caA>caC	p.Q1042H		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1042						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						CCTCATCAACTTGCTGTTCCA	0.443000													12	111					0	0	0.020292	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156632186	156632186	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr4:156632186T>C	ENST00000296518.7	+	6	1078	c.869T>C	c.(868-870)tTc>tCc	p.F290S	GUCY1A3_ENST00000511108.1_Missense_Mutation_p.F290S|GUCY1A3_ENST00000513574.1_Missense_Mutation_p.F290S|GUCY1A3_ENST00000511507.1_Missense_Mutation_p.F290S|GUCY1A3_ENST00000393832.3_Missense_Mutation_p.F32S|GUCY1A3_ENST00000455639.2_Missense_Mutation_p.F290S|GUCY1A3_ENST00000506455.1_Missense_Mutation_p.F290S			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	290					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		CCATTCCATTTCATGTTTGAC	0.443000													3	54					0	0	0.004672	0	0
FAM19A4	151647	broad.mit.edu	37	3	68802155	68802155	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr3:68802155T>C	ENST00000295569.7	-	4	637	c.145A>G	c.(145-147)Aag>Gag	p.K49E		NM_001005527.2|NM_182522.4	NP_001005527.1|NP_872328.1	Q96LR4	F19A4_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A4	49						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(5)|skin(2)	10		Lung NSC(201;0.0198)		BRCA - Breast invasive adenocarcinoma(55;1.38e-05)|Epithelial(33;0.000124)|LUSC - Lung squamous cell carcinoma(21;0.0248)|KIRC - Kidney renal clear cell carcinoma(39;0.0729)|Kidney(39;0.0904)		GTCCCTTGCTTGATTTGGTGG	0.493000													4	44					0	0	0.014758	0	0
TTN	7273	broad.mit.edu	37	2	179600395	179600395	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr2:179600395T>G	ENST00000589042.1	-	50	15002	c.14778A>C	c.(14776-14778)caA>caC	p.Q4926H	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.Q3682H|TTN_ENST00000591111.1_Missense_Mutation_p.Q4609H	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4609	Ig-like 29.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGGGAGTTTTTGCCCATCTT	0.418000													3	42					0	0	0.004672	0	0
MASTL	84930	broad.mit.edu	37	10	27454438	27454438	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr10:27454438A>G	ENST00000375946.4	+	6	1384	c.781A>G	c.(781-783)Acg>Gcg	p.T261A	MASTL_ENST00000375940.4_Missense_Mutation_p.T261A|MASTL_ENST00000342386.6_Missense_Mutation_p.T261A	NM_001172303.1|NM_032844.3	NP_001165774.1|NP_116233.2	Q96GX5	GWL_HUMAN	microtubule associated serine/threonine kinase-like	261	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			breast(3)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AAAGGACACTACGCCTTATTC	0.433000													5	57					0	0	0.021553	0	0
CMTM2	146225	broad.mit.edu	37	16	66613633	66613633	+	Silent	SNP	G	G	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr16:66613633G>A	ENST00000268595.2	+	1	274	c.123G>A	c.(121-123)gcG>gcA	p.A41A	CMTM2_ENST00000379486.2_Silent_p.A41A	NM_144673.2	NP_653274.1	Q8TAZ6	CKLF2_HUMAN	CKLF-like MARVEL transmembrane domain containing 2	41					chemotaxis	extracellular space|integral to membrane	cytokine activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	17		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.068)|Epithelial(162;0.212)		CTCAAAAGGCGGTGCAGGACC	0.622000													6	47					0	0	0.029380	0	0
OR51B6	390058	broad.mit.edu	37	11	5373366	5373366	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr11:5373366T>C	ENST00000380219.1	+	1	629	c.629T>C	c.(628-630)cTc>cCc	p.L210P	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron|HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron	NM_001004750.1	NP_001004750.1	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B, member 6	210					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	21		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTGGACTTTCTCATCATCTTT	0.438000													9	96					0	0	0.006214	0	0
ZNF22	7570	broad.mit.edu	37	10	45498963	45498963	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr10:45498963C>G	ENST00000298299.3	+	2	740	c.147C>G	c.(145-147)agC>agG	p.S49R	CEP164P1_ENST00000456938.2_RNA	NM_006963.4	NP_008894.2	P17026	ZNF22_HUMAN	zinc finger protein 22	49					odontogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|plasma membrane	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(2)|lung(2)	8		Prostate(175;0.0352)|all_neural(218;0.202)				TCAGAAGAAGCTTGGATGACA	0.438000													9	67					0	0	0.008291	0	0
CCR8	1237	broad.mit.edu	37	3	39374061	39374061	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr3:39374061C>G	ENST00000326306.4	+	2	377	c.239C>G	c.(238-240)tCt>tGt	p.S80C	CCR8_ENST00000545843.1_Intron|CCR8_ENST00000414803.1_Intron	NM_005201.3	NP_005192.1	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	80					cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			NS(3)|breast(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		CTGGCCCTGTCTGACCTGCTT	0.493000													36	307					0	0	0.017118	0	0
LUM	4060	broad.mit.edu	37	12	91502123	91502123	+	Silent	SNP	A	A	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr12:91502123A>G	ENST00000266718.4	-	2	1088	c.634T>C	c.(634-636)Tta>Cta	p.L212L	LUM_ENST00000548071.1_Intron	NM_002345.3	NP_002336.1	P51884	LUM_HUMAN	lumican	212					collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24						TTGTTGTCTAAGTAGAGAGTT	0.413000													5	76					0	0	0.014758	0	0
RAB3IP	117177	broad.mit.edu	37	12	70178515	70178515	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr12:70178515G>C	ENST00000550536.1	+	4	1031	c.574G>C	c.(574-576)Gat>Cat	p.D192H	RAB3IP_ENST00000378815.6_Missense_Mutation_p.D176H|RAB3IP_ENST00000553099.1_5'UTR|RAB3IP_ENST00000551641.1_5'UTR|RAB3IP_ENST00000247833.7_Missense_Mutation_p.D176H|RAB3IP_ENST00000325555.9_5'UTR|RAB3IP_ENST00000483530.2_Missense_Mutation_p.D176H|RAB3IP_ENST00000362025.5_Missense_Mutation_p.D192H	NM_001278402.1|NM_175623.2	NP_001265331.1|NP_783322.1	Q96QF0	RAB3I_HUMAN	RAB3A interacting protein	192					cilium assembly|Golgi to plasma membrane transport|protein localization to organelle|protein transport	actin cortical patch|centrosome|cytosol|lamellipodium|microtubule basal body|nucleus	guanyl-nucleotide exchange factor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	22	Esophageal squamous(21;0.187)		Lung(24;0.000381)|OV - Ovarian serous cystadenocarcinoma(12;0.00168)|STAD - Stomach adenocarcinoma(21;0.00694)			GAAGTTAAAAGATGAAGAATG	0.323000													4	133					0	0	0.009096	0	0
BTNL8	79908	broad.mit.edu	37	5	180377319	180377319	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr5:180377319G>C	ENST00000340184.4	+	8	1484	c.1278G>C	c.(1276-1278)caG>caC	p.Q426H	BTNL8_ENST00000505126.1_Missense_Mutation_p.Q219H|BTNL8_ENST00000511704.1_Missense_Mutation_p.Q310H|BTNL8_ENST00000231229.4_3'UTR|BTNL8_ENST00000508408.1_3'UTR|BTNL8_ENST00000400707.3_Missense_Mutation_p.Q301H|BTNL8_ENST00000533815.2_Missense_Mutation_p.Q242H	NM_001040462.2	NP_001035552.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	426	B30.2/SPRY.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TAAATGACCAGTCCCTTATTT	0.458000													12	80					0	0	0.016723	0	0
OBSCN	84033	broad.mit.edu	37	1	228493070	228493070	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr1:228493070C>G	ENST00000570156.2	+	54	14587	c.14513C>G	c.(14512-14514)gCc>gGc	p.A4838G	OBSCN_ENST00000422127.1_Intron|OBSCN_ENST00000366707.4_Missense_Mutation_p.A1515G|OBSCN_ENST00000284548.11_Intron|OBSCN_ENST00000366709.4_Intron	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3881					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AAGACGTCGGCCACTCTCACT	0.567000													15	107					0	0	0.020292	0	0
SHARPIN	81858	broad.mit.edu	37	8	145153831	145153831	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr8:145153831T>A	ENST00000398712.2	-	8	1550	c.1114A>T	c.(1114-1116)Agc>Tgc	p.S372C		NM_030974.3	NP_112236.3	Q9H0F6	SHRPN_HUMAN	SHANK-associated RH domain interactor	372					negative regulation of inflammatory response|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein linear polyubiquitination|regulation of CD40 signaling pathway|regulation of tumor necrosis factor-mediated signaling pathway	cytosol|LUBAC complex	polyubiquitin binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|lung(2)|ovary(2)	7	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.1e-42)|Epithelial(56;1.58e-40)|all cancers(56;6.12e-36)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CTCTGGGTGCTACACATCTCA	0.632000													5	30					0	0	0.021553	0	0
EP400	57634	broad.mit.edu	37	12	132547093	132547093	+	Silent	SNP	A	A	G	rs60608267	by1000genomes	TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr12:132547093A>G	ENST00000333577.4	+	48	8398	c.8289A>G	c.(8287-8289)caA>caG	p.Q2763Q	EP400_ENST00000389561.2_Silent_p.Q2727Q|EP400_ENST00000330386.6_Silent_p.Q2646Q|EP400_ENST00000332482.4_Silent_p.Q2690Q|EP400_ENST00000389562.2_Silent_p.Q2726Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2763	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2726Q(9)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcaacaacagcagcagc	0.567000													5	53					0	0	0.014758	0	0
TMEM74	157753	broad.mit.edu	37	8	109796516	109796516	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr8:109796516G>C	ENST00000297459.3	-	2	990	c.812C>G	c.(811-813)tCt>tGt	p.S271C	TMEM74_ENST00000518838.1_Intron	NM_153015.1	NP_694560.1	Q96NL1	TMM74_HUMAN	transmembrane protein 74	271					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(57;3.08e-10)			GAGTTTTGCAGACTCTTTGGA	0.488000													5	43					0	0	0.014758	0	0
DCST2	127579	broad.mit.edu	37	1	155004049	155004049	+	Splice_Site	SNP	C	C	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr1:155004049C>T	ENST00000368424.3	-	4	798		c.e4+1		DCST2_ENST00000295536.5_Splice_Site	NM_144622.2	NP_653223.2	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2							integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|prostate(1)|skin(1)	38	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GGTTTTCTCACGGCTGGCAAG	0.597000													19	55					0	0	0.008871	0	0
OLFM3	118427	broad.mit.edu	37	1	102270070	102270070	+	Silent	SNP	A	A	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr1:102270070A>G	ENST00000370103.4	-	6	1314	c.1101T>C	c.(1099-1101)acT>acC	p.T367T	OLFM3_ENST00000536598.1_3'UTR|OLFM3_ENST00000338858.5_Silent_p.T387T|OLFM3_ENST00000462354.1_5'UTR	NM_058170.2	NP_477518.2	Q96PB7	NOE3_HUMAN	olfactomedin 3	387	Olfactomedin-like.					extracellular region				breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(24)|ovary(3)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	43		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		TGGGGTAGCCAGTGCTCCAGC	0.478000													11	77					0	0	0.008291	0	0
HBD	3045	broad.mit.edu	37	11	5255363	5255363	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr11:5255363T>G	ENST00000380299.3	-	2	387	c.173A>C	c.(172-174)aAc>aCc	p.N58T	HBD_ENST00000292901.3_Missense_Mutation_p.N58T	NM_000519.3	NP_000510.1	P02042	HBD_HUMAN	hemoglobin, delta	58			N -> K (in Campania; dbSNP:rs35666685).		blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			endometrium(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	16		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;5.69e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CACCTTAGGGTTGCCCATAAC	0.527000													15	78					0	0	0.028581	0	0
SSX2IP	117178	broad.mit.edu	37	1	85136353	85136353	+	Silent	SNP	T	T	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr1:85136353T>C	ENST00000437941.2	-	2	460	c.108A>G	c.(106-108)gaA>gaG	p.E36E	SSX2IP_ENST00000342203.3_Silent_p.E63E|SSX2IP_ENST00000603677.1_Intron|SSX2IP_ENST00000370612.4_Silent_p.E63E|SSX2IP_ENST00000605755.1_Silent_p.E36E	NM_001166295.1|NM_001166417.1	NP_001159767.1|NP_001159889.1	Q9Y2D8	ADIP_HUMAN	synovial sarcoma, X breakpoint 2 interacting protein	63					cell adhesion	nucleus|protein complex				endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)|urinary_tract(1)	19				all cancers(265;0.0053)|Epithelial(280;0.0214)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		AGATACTCTGTTCAATATTAT	0.299000													8	71					0	0	0.003080	0	0
PDE1C	5137	broad.mit.edu	37	7	31793050	31793050	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr7:31793050C>G	ENST00000396193.1	-	19	2851	c.2258G>C	c.(2257-2259)aGg>aCg	p.R753T	PDE1C_ENST00000321453.7_Missense_Mutation_p.R693T|PDE1C_ENST00000396191.1_Missense_Mutation_p.R693T	NM_001191058.1	NP_001177987.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	693					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			CATTTTGATCCTCTGATCCAG	0.448000													13	260					0	0	0.013537	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73280628	73280628	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr4:73280628G>A	ENST00000286657.4	-	4	601	c.565C>T	c.(565-567)Cag>Tag	p.Q189*		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	189					collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TCCTCCATCTGTTTACCTCTT	0.368000													6	55					0	0	0.029380	0	0
PCDH15	65217	broad.mit.edu	37	10	55587280	55587280	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr10:55587280G>A	ENST00000373965.2	-	33	4655	c.4261C>T	c.(4261-4263)Cga>Tga	p.R1421*	PCDH15_ENST00000395445.1_Nonsense_Mutation_p.R1421*|PCDH15_ENST00000409834.1_Nonsense_Mutation_p.R1025*|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000414778.1_Nonsense_Mutation_p.R1416*|PCDH15_ENST00000320301.6_Nonsense_Mutation_p.R1414*|PCDH15_ENST00000437009.1_Nonsense_Mutation_p.R1343*|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395430.1_Nonsense_Mutation_p.R1411*|PCDH15_ENST00000395432.2_Nonsense_Mutation_p.R1374*|PCDH15_ENST00000395438.1_Nonsense_Mutation_p.R1414*|PCDH15_ENST00000361849.3_Nonsense_Mutation_p.R1414*|PCDH15_ENST00000395433.1_Nonsense_Mutation_p.R1389*|PCDH15_ENST00000373957.3_Intron	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1414					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GCCTGAATTCGTGCAGTCTTT	0.537000										HNSCC(58;0.16)			6	58					0	0	0.003080	0	0
MYLK3	91807	broad.mit.edu	37	16	46764535	46764535	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr16:46764535T>C	ENST00000394809.4	-	5	1653	c.1538A>G	c.(1537-1539)tAc>tGc	p.Y513C	MYLK3_ENST00000536476.1_Missense_Mutation_p.Y172C	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	513					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				GCACACCTCGTAACCCGCAGA	0.612000													3	72					0	0	0.004672	0	0
OR2AG1	144125	broad.mit.edu	37	11	6806470	6806470	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr11:6806470C>G	ENST00000307401.4	+	1	223	c.202C>G	c.(202-204)Ctc>Gtc	p.L68V		NM_001004489.2	NP_001004489.1	Q9H205	O2AG1_HUMAN	olfactory receptor, family 2, subfamily AG, member 1	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(13)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.19e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GCAGCTCTCTCTCATGGACCT	0.552000													4	165					0	0	0.009096	0	0
ETF1	2107	broad.mit.edu	37	5	137846839	137846839	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr5:137846839C>T	ENST00000499810.2	-	8	1262	c.814G>A	c.(814-816)Gtt>Att	p.V272I	ETF1_ENST00000503014.1_Missense_Mutation_p.V291I|ETF1_ENST00000360541.5_Missense_Mutation_p.V305I			P62495	ERF1_HUMAN	eukaryotic translation termination factor 1	305					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein methylation|regulation of translational termination	cytoplasm	protein binding|ribosome binding|translation release factor activity, codon specific			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)|urinary_tract(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GTATCTTCAACGCCAAAACAG	0.388000													7	63					0	0	0.029380	0	0
CUL9	23113	broad.mit.edu	37	6	43152353	43152353	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr6:43152353G>A	ENST00000252050.4	+	2	389	c.305G>A	c.(304-306)cGa>cAa	p.R102Q	CUL9_ENST00000372647.2_Missense_Mutation_p.R102Q|CUL9_ENST00000354495.3_Missense_Mutation_p.R102Q	NM_015089.2	NP_055904.1	Q8IWT3	CUL9_HUMAN	cullin 9	102					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|liver(1)|lung(30)|ovary(5)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(4)	92						AGCTTTCCTCGAGATCCAGGA	0.602000													10	115					0	0	0.008291	0	0
GUCY1B3	2983	broad.mit.edu	37	4	156710914	156710914	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr4:156710914C>T	ENST00000264424.8	+	5	428	c.346C>T	c.(346-348)Cgt>Tgt	p.R116C	GUCY1B3_ENST00000505764.1_Missense_Mutation_p.R96C|GUCY1B3_ENST00000503520.1_Missense_Mutation_p.R116C|GUCY1B3_ENST00000507146.1_Missense_Mutation_p.R48C|GUCY1B3_ENST00000513437.1_Missense_Mutation_p.R48C|GUCY1B3_ENST00000502959.1_Missense_Mutation_p.R138C|GUCY1B3_ENST00000505154.1_Missense_Mutation_p.R48C	NM_000857.2	NP_000848.1	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	116					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		CCCAGGAATGCGTGCACCTTC	0.463000													8	98					0	0	0.003080	0	0
ARRDC1	92714	broad.mit.edu	37	9	140507428	140507428	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr9:140507428T>A	ENST00000371421.4	+	2	263	c.199T>A	c.(199-201)Ttc>Atc	p.F67I	ARRDC1_ENST00000491911.1_3'UTR	NM_152285.2	NP_689498.1	Q8N5I2	ARRD1_HUMAN	arrestin domain containing 1	67										breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(4)|prostate(1)|urinary_tract(1)	13	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000273)|Epithelial(140;0.000464)		GGAGGGTTACTTCAACAGTTC	0.602000													3	23					0	0	0.009096	0	0
HNRNPF	3185	broad.mit.edu	37	10	43883047	43883047	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr10:43883047C>T	ENST00000443950.2	-	3	772	c.286G>A	c.(286-288)Gtg>Atg	p.V96M	HNRNPF_ENST00000337970.3_Missense_Mutation_p.V96M|HNRNPF_ENST00000356053.3_Missense_Mutation_p.V96M|HNRNPF_ENST00000357065.4_Missense_Mutation_p.V96M|HNRNPF_ENST00000544000.1_Missense_Mutation_p.V96M	NM_001098208.1	NP_001091678.1	P52597	HNRPF_HUMAN	heterogeneous nuclear ribonucleoprotein F	96					regulation of RNA splicing	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|urinary_tract(1)	19						TGCTTCAACACCCAATCCATC	0.498000													6	58					0	0	0.029380	0	0
PHF21A	51317	broad.mit.edu	37	11	46001496	46001496	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr11:46001496G>A	ENST00000257821.4	-	6	798	c.175C>T	c.(175-177)Cgg>Tgg	p.R59W	PHF21A_ENST00000323180.6_Missense_Mutation_p.R59W|PHF21A_ENST00000418153.2_Missense_Mutation_p.R59W	NM_001101802.1	NP_001095272.1	Q96BD5	PF21A_HUMAN	PHD finger protein 21A	59	Gln-rich.				blood coagulation|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(10)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	29						AGGTTCTTCCGTAGCTGTTCA	0.383000													4	54					0	0	0.009096	0	0
NUP205	23165	broad.mit.edu	37	7	135263592	135263592	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr7:135263592G>A	ENST00000285968.6	+	7	997	c.971G>A	c.(970-972)gGg>gAg	p.G324E	NUP205_ENST00000440390.2_Missense_Mutation_p.G118E	NM_015135.2	NP_055950.1	Q92621	NU205_HUMAN	nucleoporin 205kDa	324					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						AAACTGCCTGGGCTCCAAGCC	0.443000													5	73					0	0	0.014758	0	0
ZNF211	10520	broad.mit.edu	37	19	58153368	58153368	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr19:58153368G>C	ENST00000544273.1	+	5	1877	c.1550G>C	c.(1549-1551)gGa>gCa	p.G517A	ZNF211_ENST00000391703.3_Missense_Mutation_p.G444A|ZNF211_ENST00000347302.3_Missense_Mutation_p.G505A|ZNF211_ENST00000299871.5_Missense_Mutation_p.G570A|ZNF211_ENST00000254182.7_Missense_Mutation_p.G496A|ZNF211_ENST00000240731.4_Missense_Mutation_p.G518A|ZNF211_ENST00000541801.1_Missense_Mutation_p.G496A|ZNF211_ENST00000420680.1_Missense_Mutation_p.G509A			Q13398	ZN211_HUMAN	zinc finger protein 211	505						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GTTCACACTGGAGAAAGGCCT	0.443000													6	44					0	0	0.021553	0	0
RP5-827C21.2	0	broad.mit.edu	37	1	234492755	234492757	+	RNA	DEL	GCC	GCC	-			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr1:234492755_234492757delGCC	ENST00000425104.1	+	0	4_6																											CCCCGGTTCAGCCGCCGCCGCTG	0.660													2	4	---	---	---	---					
KRTAP5-1	387264	broad.mit.edu	37	11	1605880	1605882	+	In_Frame_Del	DEL	GCC	GCC	-			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr11:1605880_1605882delGCC	ENST00000382171.2	-	1	631_633	c.598_600delGGC	c.(598-600)del	p.G200del	KRTAP5-AS1_ENST00000532922.1_RNA|KRTAP5-AS1_ENST00000534077.1_RNA|KRTAP5-AS1_ENST00000424148.1_RNA|KRTAP5-AS1_ENST00000524947.1_RNA	NM_001005922.1	NP_001005922.1	Q6L8H4	KRA51_HUMAN	keratin associated protein 5-1	200	8 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(3)|kidney(1)|lung(9)|skin(2)|upper_aerodigestive_tract(1)	16		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		AGCCCCCACAGCCGGAGCCACAA	0.665													11	111	---	---	---	---					
LOC101927708	101927708	broad.mit.edu	37	11	3552650	3552651	+	RNA	INS	-	-	G	rs34642454		TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr11:3552650_3552651insG	ENST00000527970.1	-	0	285																											CAGCACCCCATGGGGGGGCCCT	0.500													2	4	---	---	---	---					
LRRC75A-AS1	125144	broad.mit.edu	37	17	16344166	16344167	+	RNA	INS	-	-	A	rs149284927		TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr17:16344166_16344167insA	ENST00000475953.1	+	0	483				C17orf76-AS1_ENST00000580180.1_RNA|C17orf76-AS1_ENST00000478103.2_RNA|C17orf76-AS1_ENST00000472367.1_RNA|C17orf76-AS1_ENST00000481027.1_RNA|C17orf76-AS1_ENST00000481898.1_RNA|C17orf76-AS1_ENST00000584926.1_RNA|C17orf76-AS1_ENST00000483140.1_RNA|C17orf76-AS1_ENST00000492250.1_RNA|C17orf76-AS1_ENST00000581718.1_RNA|C17orf76-AS1_ENST00000470491.2_RNA|C17orf76-AS1_ENST00000484836.1_RNA|C17orf76-AS1_ENST00000584141.1_RNA|C17orf76-AS1_ENST00000491009.1_RNA|C17orf76-AS1_ENST00000579473.1_RNA|RP11-138I1.3_ENST00000585048.1_lincRNA|C17orf76-AS1_ENST00000580770.1_RNA|C17orf76-AS1_ENST00000460249.1_RNA|C17orf76-AS1_ENST00000584177.1_RNA|C17orf76-AS1_ENST00000581913.1_RNA|C17orf76-AS1_ENST00000487066.1_RNA|C17orf76-AS1_ENST00000583400.2_RNA|C17orf76-AS1_ENST00000477249.2_RNA|C17orf76-AS1_ENST00000475947.2_RNA|C17orf76-AS1_ENST00000582911.1_RNA|C17orf76-AS1_ENST00000480811.1_RNA	NR_027667.1																						gactccatctcaaaaaaaaaaa	0.416													3	5	---	---	---	---					
TBC1D3P2	440452	broad.mit.edu	37	17	60347260	60347260	+	RNA	DEL	T	T	-	rs71816198		TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr17:60347260delT	ENST00000581291.1	-	0	581																				breast(2)|kidney(1)|lung(2)	5						CTCTGAATGATTTTTTTTTTT	0.448													3	3	---	---	---	---					
GAGE2D	729408	broad.mit.edu	37	X	49208295	49208296	+	In_Frame_Ins	INS	-	-	TAT			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chrX:49208295_49208296insTAT	ENST00000404720.2	+	2	96_97	c.24_25insTAT	c.(22-27)acatcg>acTATatcg	p.8_9TS>TIS		NM_001098407.1|NM_012196.1	NP_001091877.1|NP_036328.1			G antigen 2D																		GAAGATCGACCTATCGGCCTAG	0.465													8	10	---	---	---	---					
PLP1	5354	broad.mit.edu	37	X	103041638	103041639	+	Frame_Shift_Ins	INS	-	-	TA			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chrX:103041638_103041639insTA	ENST00000418604.1	+	4	716_717	c.436_437insTA	c.(436-438)aggfs	p.R146fs	PLP1_ENST00000361621.2_Intron|PLP1_ENST00000303958.2_Frame_Shift_Ins_p.R146fs	NM_001128834.1	NP_001122306.1	P60201	MYPR_HUMAN	proteolipid protein 1	146			Missing (in HLD1).		cell death|synaptic transmission	integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	17						GGGAAAATGGCTAGGACATCCC	0.564													26	77	---	---	---	---