Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FRG1B	284802	broad.mit.edu	37	20	29625955	29625955	+	Nonsense_Mutation	SNP	A	A	T			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr20:29625955A>T	ENST00000278882.3	+	5	579	c.199A>T	c.(199-201)Aga>Tga	p.R67*	FRG1B_ENST00000358464.4_Nonsense_Mutation_p.R67*|FRG1B_ENST00000439954.2_Nonsense_Mutation_p.R72*																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AATTGGACCAAGAGAACAATG	0.338000													5	83					0	0	0.014758	0	0
FAT1	2195	broad.mit.edu	37	4	187525580	187525580	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr4:187525580G>A	ENST00000441802.2	-	18	10708	c.10499C>T	c.(10498-10500)tCa>tTa	p.S3500L		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	3500	Cadherin 32.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						GATGGCAGATGATGTCAGGAG	0.433000										HNSCC(5;0.00058)			5	55					0	0	0.021553	0	0
HNRNPH1	3187	broad.mit.edu	37	5	179050094	179050094	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr5:179050094T>G	ENST00000356731.5	-	1	1576	c.41A>C	c.(40-42)aAg>aCg	p.K14T	HNRNPH1_ENST00000442819.2_Missense_Mutation_p.K14T|HNRNPH1_ENST00000524180.1_5'UTR|HNRNPH1_ENST00000510411.1_Missense_Mutation_p.K14T|HNRNPH1_ENST00000393432.4_Missense_Mutation_p.K14T|HNRNPH1_ENST00000329433.6_Missense_Mutation_p.K14T			P31943	HNRH1_HUMAN	heterogeneous nuclear ribonucleoprotein H1 (H)	14	RRM 1.				regulation of RNA splicing	actin cytoskeleton|catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|poly(U) RNA binding|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|skin(1)	14						GCCCCGGACCTTCACCACGAA	0.582000													13	29					0	0	0.033300	0	0
TDRD1	56165	broad.mit.edu	37	10	115980454	115980454	+	Silent	SNP	C	C	T			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr10:115980454C>T	ENST00000251864.2	+	19	2775	c.2622C>T	c.(2620-2622)acC>acT	p.T874T	TDRD1_ENST00000422662.1_Silent_p.T478T|TDRD1_ENST00000369282.1_Silent_p.T874T|TDRD1_ENST00000369281.2_Silent_p.T760T|TDRD1_ENST00000369280.1_Silent_p.T874T	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	874					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		TTGAACTCACCGATCTCTCCA	0.393000													9	25					0	0	0.058154	0	0
PC	5091	broad.mit.edu	37	11	66616543	66616543	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr11:66616543C>G	ENST00000393960.1	-	23	3645	c.3364G>C	c.(3364-3366)Gac>Cac	p.D1122H	PC_ENST00000529047.1_Missense_Mutation_p.D242H|PC_ENST00000393955.2_Missense_Mutation_p.D1122H|PC_ENST00000528224.1_5'UTR|PC_ENST00000393958.2_Missense_Mutation_p.D1122H	NM_001040716.1	NP_001035806.1	P11498	PYC_HUMAN	pyruvate carboxylase	1122	Biotinyl-binding.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	ACTTTGATGTCTATCACCTTC	0.612000													178	75					0	0	0.048971	0	0
CNTN4	152330	broad.mit.edu	37	3	3076327	3076327	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr3:3076327C>T	ENST00000397461.1	+	16	2179	c.1795C>T	c.(1795-1797)Ccc>Tcc	p.P599S	CNTN4_ENST00000418658.1_Missense_Mutation_p.P599S|CNTN4_ENST00000448906.2_Missense_Mutation_p.P271S|CNTN4_ENST00000358480.3_Missense_Mutation_p.P380S|CNTN4_ENST00000397459.2_Missense_Mutation_p.P271S|CNTN4_ENST00000427331.1_Missense_Mutation_p.P599S	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	599	Fibronectin type-III 1.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding	p.P271S(1)|p.P599S(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		TCCTCCAGGTCCCCCAGAGGC	0.527000													11	40					0	0	0.093190	0	0
BAGE2	85319	broad.mit.edu	37	21	11058349	11058349	+	RNA	SNP	T	T	G	rs209032		TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr21:11058349T>G	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GAGAGAAATCTCTTTATAAAA	0.338000													10	71					0	0	0.069234	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110439320	110439320	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr8:110439320A>G	ENST00000378402.5	+	25	3039	c.2935A>G	c.(2935-2937)Acc>Gcc	p.T979A		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	979					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ACGAGAGGGAACCTGTGCTGG	0.522000										HNSCC(38;0.096)			32	45					0	0	0.045705	0	0
BRD7	29117	broad.mit.edu	37	16	50357602	50357602	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr16:50357602C>A	ENST00000394688.3	-	12	1498	c.1339G>T	c.(1339-1341)Gag>Tag	p.E447*	BRD7_ENST00000394689.2_Nonsense_Mutation_p.E447*			Q9NPI1	BRD7_HUMAN	bromodomain containing 7	447					cell cycle|negative regulation of cell proliferation|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of histone acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleus	histone acetyl-lysine binding|p53 binding|transcription coactivator activity|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|prostate(2)|urinary_tract(2)	22		all_cancers(37;0.0127)				GCCAAAAACTCATGGATGCTG	0.458000													22	11					1.96292e-10	2.37186e-10	0.055883	1	0
FRAS1	80144	broad.mit.edu	37	4	79366910	79366910	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr4:79366910T>C	ENST00000325942.6	+	42	6340	c.5900T>C	c.(5899-5901)aTa>aCa	p.I1967T	FRAS1_ENST00000264895.6_Intron	NM_001166133.1	NP_001159605.1	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	0					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TTGACCACAATATTTCACACC	0.378000													45	48					0	0	0.039052	0	0
FBN1	2200	broad.mit.edu	37	15	48704920	48704920	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr15:48704920C>T	ENST00000316623.5	-	65	8527	c.8072G>A	c.(8071-8073)gGc>gAc	p.G2691D	FBN1_ENST00000561429.1_5'UTR	NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	2691					heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		TCGGCCCATGCCCATTCCAGA	0.502000													4	175					0	0	0.014758	0	0
PARP4	143	broad.mit.edu	37	13	25077906	25077906	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr13:25077906C>A	ENST00000381989.3	-	2	114	c.9G>T	c.(7-9)atG>atT	p.M3I		NM_006437.3	NP_006428.2	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	3	BRCT.				cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(18)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		CAAAGATTCCCATCACCATCC	0.353000													17	24					5.35267e-07	6.20909e-07	0.043863	1	0
COX7A2	1347	broad.mit.edu	37	6	75950901	75950901	+	Silent	SNP	T	T	C			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr6:75950901T>C	ENST00000370081.2	-	3	505	c.195A>G	c.(193-195)aaA>aaG	p.K65K	COX7A2_ENST00000230459.4_Silent_p.K33K|COX7A2_ENST00000509698.1_Silent_p.K33K|COX7A2_ENST00000460985.1_Intron|COX7A2_ENST00000370089.2_Silent_p.K65K|COX7A2_ENST00000472311.2_Silent_p.K33K			P14406	CX7A2_HUMAN	cytochrome c oxidase subunit VIIa polypeptide 2 (liver)	33						mitochondrial respiratory chain	cytochrome-c oxidase activity|electron carrier activity			kidney(2)|lung(1)	3						CCTGGAACAGTTTTTGCTTCT	0.343000													4	88					0	0	0.021553	0	0
DRD5	1816	broad.mit.edu	37	4	9784929	9784929	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr4:9784929G>C	ENST00000304374.2	+	1	1672	c.1276G>C	c.(1276-1278)Gac>Cac	p.D426H		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	426					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CCGGGAGGTGGACAACGACGA	0.567000													10	64					0	0	0.058154	0	0
CEACAM19	56971	broad.mit.edu	37	19	45176143	45176143	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr19:45176143C>T	ENST00000358777.4	+	2	811	c.331C>T	c.(331-333)Cgc>Tgc	p.R111C	CTB-171A8.1_ENST00000590796.1_RNA|CEACAM19_ENST00000480278.1_3'UTR|CEACAM19_ENST00000403660.3_Missense_Mutation_p.R111C	NM_001127893.1|NM_020219.3	NP_001121365.1|NP_064604.2	Q7Z692	CEA19_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 19	111						integral to membrane				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)	11	Lung NSC(12;0.00308)|all_lung(12;0.00806)	Prostate(69;0.0376)				GCTGCTGCGCCGCGCCCAGCC	0.557000													156	355					0	0	0.048971	0	0
KCNB2	9312	broad.mit.edu	37	8	73849115	73849115	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr8:73849115G>A	ENST00000523207.1	+	3	2113	c.1525G>A	c.(1525-1527)Gag>Aag	p.E509K		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	509					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			CAAGTCTTTCGAGAATAAGTA	0.542000													54	70					0	0	0.048971	0	0
ITGAV	3685	broad.mit.edu	37	2	187506113	187506113	+	Splice_Site	SNP	T	T	G			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr2:187506113T>G	ENST00000261023.3	+	12	1231	c.956_splice	c.e12-1	p.D319_splice	ITGAV_ENST00000374907.3_Splice_Site_p.D283_splice|AC017101.10_ENST00000453665.1_RNA|ITGAV_ENST00000433736.2_Splice_Site_p.D273_splice	NM_002210.3	NP_002201.1	P06756	ITAV_HUMAN	integrin, alpha V	319					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		GTTCTTCTAGTTATGCAGATG	0.428000													21	67					0	0	0.049695	0	0
STARD8	9754	broad.mit.edu	37	X	67940175	67940175	+	Silent	SNP	A	A	C			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chrX:67940175A>C	ENST00000252336.6	+	7	2091	c.1719A>C	c.(1717-1719)ccA>ccC	p.P573P	STARD8_ENST00000374597.3_Silent_p.P573P|STARD8_ENST00000374599.3_Silent_p.P653P	NM_014725.4	NP_055540.2	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain containing 8	573	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity	p.P573P(4)|p.P653P(2)		NS(2)|breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	50						TTGGGGTGCCACCCCTCATCC	0.577000													5	17					0	0	0.014758	0	0
FRMD4B	23150	broad.mit.edu	37	3	69221132	69221132	+	Splice_Site	SNP	T	T	C			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr3:69221132T>C	ENST00000542259.1	-	24	3274	c.2822_splice	c.e24-1	p.R941_splice	FRMD4B_ENST00000398540.3_Splice_Site_p.R995_splice|FRMD4B_ENST00000478263.1_Splice_Site_p.R647_splice			Q9Y2L6	FRM4B_HUMAN	FERM domain containing 4B	995						cytoplasm|cytoskeleton	binding			NS(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(3)|prostate(3)|skin(2)	19		Lung NSC(201;0.0138)|Prostate(884;0.11)		BRCA - Breast invasive adenocarcinoma(55;0.000201)|Epithelial(33;0.00141)|LUSC - Lung squamous cell carcinoma(21;0.00999)|Lung(16;0.0182)		CTGTGTATTGTCTATTAAAGA	0.393000													70	64					0	0	0.048971	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887612	12887612	+	Missense_Mutation	SNP	T	T	C	rs60558629		TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr1:12887612T>C	ENST00000535591.1	-	3	440	c.245A>G	c.(244-246)cAt>cGt	p.H82R		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	82								p.H82R(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						GAAGCACCCATGGGCCATAGC	0.488000													7	356					0	0	0.029380	0	0
IL7R	3575	broad.mit.edu	37	5	35875627	35875627	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr5:35875627G>A	ENST00000303115.3	+	7	943	c.814G>A	c.(814-816)Gta>Ata	p.V272I	IL7R_ENST00000343305.4_Silent_p.S240S|IL7R_ENST00000506850.1_Silent_p.S240S	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	272					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			TAAGCCTATCGTATGGCCCAG	0.428000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						8	25					0	0	0.058154	0	0
NUP88	4927	broad.mit.edu	37	17	5290080	5290080	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr17:5290080T>A	ENST00000573584.1	-	16	2619	c.2110A>T	c.(2110-2112)Att>Ttt	p.I704F		NM_002532.4	NP_002523.2	Q99567	NUP88_HUMAN	nucleoporin 88kDa	704					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	transporter activity			endometrium(4)|kidney(4)|large_intestine(4)|lung(3)	15						CTGAGAATAATGGTGGGTTTT	0.363000													39	60					0	0	0.111260	0	0
PTPN22	26191	broad.mit.edu	37	1	114380371	114380371	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr1:114380371G>A	ENST00000359785.5	-	13	1786	c.1651C>T	c.(1651-1653)Ctt>Ttt	p.L551F	PTPN22_ENST00000538253.1_Missense_Mutation_p.L307F|PTPN22_ENST00000420377.2_Missense_Mutation_p.L551F|PTPN22_ENST00000525799.1_Missense_Mutation_p.L424F|PTPN22_ENST00000460620.1_Intron|PTPN22_ENST00000528414.1_Missense_Mutation_p.L496F	NM_001193431.1|NM_015967.5	NP_001180360.1|NP_057051.3	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	551					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(1)|kidney(3)|large_intestine(4)|lung(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGTAAATCAAGAGACATCTTA	0.383000													15	28					0	0	0.024245	0	0
TEX15	56154	broad.mit.edu	37	8	30703556	30703556	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr8:30703556A>G	ENST00000256246.2	-	1	3052	c.2978T>C	c.(2977-2979)cTt>cCt	p.L993P		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	993										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TTTTCTGGAAAGACATTTGCT	0.338000													37	92					0	0	0.069456	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				30	43					0	0	0.041601	0	0
PEX19	5824	broad.mit.edu	37	1	160253385	160253385	+	Missense_Mutation	SNP	G	G	A	rs144256391	byFrequency	TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr1:160253385G>A	ENST00000368072.5	-	2	136	c.115C>T	c.(115-117)Cct>Tct	p.P39S	DCAF8_ENST00000556710.1_Intron|PEX19_ENST00000532508.1_5'UTR|PEX19_ENST00000440949.3_5'UTR	NM_001193644.1|NM_002857.3	NP_001180573.1|NP_002848.1			peroxisomal biogenesis factor 19											cervix(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(2)	11	all_cancers(52;1.27e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GTGGTAGAAGGGGGTGCTGGG	0.547000													30	37					0	0	0.037714	0	0
LOC645752	645752	broad.mit.edu	37	15	78211548	78211548	+	RNA	SNP	T	T	C			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr15:78211548T>C	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCACCTGGGATTGGAGCTTTC	0.562000													6	177					0	0	0.021553	0	0
ZNF277	11179	broad.mit.edu	37	7	111958309	111958309	+	Missense_Mutation	SNP	G	G	A	rs143437932	byFrequency	TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr7:111958309G>A	ENST00000361822.3	+	5	667	c.538G>A	c.(538-540)Gaa>Aaa	p.E180K	ZNF277_ENST00000450657.1_Missense_Mutation_p.E180K	NM_021994.2	NP_068834.2	Q9NRM2	ZN277_HUMAN	zinc finger protein 277	180						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	15						GTTTTGCAATGAAGAATTCCT	0.333000													18	26					0	0	0.038395	0	0
MIB1	57534	broad.mit.edu	37	18	19444569	19444569	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr18:19444569G>C	ENST00000261537.6	+	21	3227	c.2963G>C	c.(2962-2964)cGc>cCc	p.R988P	MIB1_ENST00000578646.1_3'UTR	NM_020774.2	NP_065825.1	Q86YT6	MIB1_HUMAN	mindbomb E3 ubiquitin protein ligase 1	988					Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|ovary(5)	27			STAD - Stomach adenocarcinoma(5;0.212)			TGTGGAGACCGCATGAGTGAA	0.403000													11	91					0	0	0.069234	0	0
PTRF	284119	broad.mit.edu	37	17	40574746	40574746	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr17:40574746C>T	ENST00000357037.5	-	1	789	c.370G>A	c.(370-372)Gtg>Atg	p.V124M		NM_012232.5	NP_036364.2	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	124					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|urinary_tract(1)	17		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		CTGCCGCGCACGGTCTTCACG	0.632000													9	10					0	0	0.058154	0	0
KIAA1033	23325	broad.mit.edu	37	12	105519825	105519825	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr12:105519825C>A	ENST00000332180.5	+	11	917	c.830C>A	c.(829-831)tCt>tAt	p.S277Y		NM_015275.1	NP_056090.1	Q2M389	WAHS7_HUMAN	KIAA1033	277					endosome transport	WASH complex				breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	41						GGAGGAGTATCTGTGTCAAAA	0.328000													7	17					3.09899e-07	3.6434e-07	0.047766	1	0
ASPM	259266	broad.mit.edu	37	1	197115395	197115395	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr1:197115395C>A	ENST00000367409.4	-	1	429	c.173G>T	c.(172-174)gGa>gTa	p.G58V	ASPM_ENST00000294732.7_Missense_Mutation_p.G58V	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	58					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						CCGTGAGGCTCCCAGGAGAAC	0.652000													55	84					6.75472e-32	8.39515e-32	0.048971	1	0
ARHGAP36	158763	broad.mit.edu	37	X	130218329	130218329	+	Silent	SNP	G	G	A			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chrX:130218329G>A	ENST00000276211.5	+	5	1041	c.696G>A	c.(694-696)gcG>gcA	p.A232A	ARHGAP36_ENST00000370921.1_Silent_p.A96A|ARHGAP36_ENST00000370922.1_Silent_p.A220A	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	232	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						ATCCGATTGCGAAACAAATCC	0.468000													24	7					0	0	0.076483	0	0
SLC44A1	23446	broad.mit.edu	37	9	108120631	108120631	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr9:108120631C>G	ENST00000374720.3	+	7	924	c.677C>G	c.(676-678)tCc>tGc	p.S226C	SLC44A1_ENST00000374724.1_Missense_Mutation_p.S226C|SLC44A1_ENST00000343170.7_Missense_Mutation_p.S18C|SLC44A1_ENST00000374723.1_Missense_Mutation_p.S226C	NM_080546.3	NP_536856.2	Q8WWI5	CTL1_HUMAN	solute carrier family 44 (choline transporter), member 1	226						integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(16)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	38					Choline(DB00122)	GCAGTTCTATCCATGATTTTG	0.338000													35	58					0	0	0.069456	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887606	12887606	+	Missense_Mutation	SNP	C	C	G	rs58074988		TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr1:12887606C>G	ENST00000535591.1	-	3	446	c.251G>C	c.(250-252)tGc>tCc	p.C84S		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	84								p.C84S(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						ATTGAGGAAGCACCCATGGGC	0.483000													6	337					0	0	0.021553	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522772	95522772	+	RNA	SNP	T	T	C			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr2:95522772T>C	ENST00000432432.2	-	0	255					NR_040113.1													p.E49G(1)									GCGCTCCACCTCCGCGGCGTC	0.682000													4	65					0	0	0.021553	0	0
ASPM	259266	broad.mit.edu	37	1	197115396	197115396	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr1:197115396C>A	ENST00000367409.4	-	1	428	c.172G>T	c.(172-174)Gga>Tga	p.G58*	ASPM_ENST00000294732.7_Nonsense_Mutation_p.G58*	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	58					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						CGTGAGGCTCCCAGGAGAACG	0.652000													53	84					5.82218e-30	7.13422e-30	0.048971	1	0
FPR3	2359	broad.mit.edu	37	19	52327145	52327145	+	Silent	SNP	C	C	A			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr19:52327145C>A	ENST00000339223.4	+	2	323	c.144C>A	c.(142-144)atC>atA	p.I48I	FPR3_ENST00000595991.1_Silent_p.I48I	NM_002030.3	NP_002021.3	P25089	FPR3_HUMAN	formyl peptide receptor 3	48					cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			NS(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)	35						GGCTTGTGATCTGGGTGGCTG	0.552000													27	53					1.7881e-09	2.13103e-09	0.037714	1	0
FRG1B	284802	broad.mit.edu	37	20	29628225	29628225	+	Splice_Site	SNP	A	A	G			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr20:29628225A>G	ENST00000278882.3	+	6	608		c.e6-1		FRG1B_ENST00000358464.4_Splice_Site|FRG1B_ENST00000439954.2_Splice_Site																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TGTTTCACTTAGGGGAAAATG	0.358000													5	77					0	0	0.058154	0	0
BCRP7	100133163	broad.mit.edu	37	22	18844888	18844888	+	RNA	SNP	A	A	G			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr22:18844888A>G	ENST00000412938.1	+	0	3138																											GCTCACGGAAATACAGCTTCA	0.587000													7	98					0	0	0.029380	0	0
KRTAP4-8	728224	broad.mit.edu	37	17	39254054	39254054	+	Missense_Mutation	SNP	A	A	T	rs76270529	by1000genomes	TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr17:39254054A>T	ENST00000333822.4	-	1	339	c.283T>A	c.(283-285)Tgc>Agc	p.C95S		NM_031960.2	NP_114166.1	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4-8	95	25 X 5 AA repeats of C-C-[IKRQVHEC]- [SPRT]-[STCVQPR].					keratin filament		p.C95S(4)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|prostate(1)	11						ctggagatgcagcagcTAGGG	0.677000													5	40					0	0	0.021553	0	0
LOC645752	645752	broad.mit.edu	37	15	78211517	78211517	+	RNA	SNP	C	C	G			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr15:78211517C>G	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							TTGCTCAGGACACTCAAGGCC	0.557000													4	182					0	0	0.009096	0	0
ST8SIA5	29906	broad.mit.edu	37	18	44336343	44336343	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr18:44336343C>G	ENST00000315087.7	-	1	789	c.129G>C	c.(127-129)aaG>aaC	p.K43N	ST8SIA5_ENST00000538168.1_Missense_Mutation_p.K43N|ST8SIA5_ENST00000536490.1_Missense_Mutation_p.K43N	NM_013305.4	NP_037437.2	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5	43					glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				kidney(1)|large_intestine(10)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	22						TTTCTTACCTCTTAATGTAGT	0.617000													12	20					0	0	0.105934	0	0
FREM1	158326	broad.mit.edu	37	9	14776250	14776250	+	Translation_Start_Site	SNP	A	A	G			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr9:14776250A>G	ENST00000380894.1	-	2	90	c.2T>C	c.(1-3)aTg>aCg	p.M1T	FREM1_ENST00000422223.2_Intron|FREM1_ENST00000380881.4_Intron|FREM1_ENST00000380880.3_Intron	NM_001177704.1	NP_001171175.1	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	0					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		TTGTGTCACCATCTACTGGAA	0.438000													7	12					0	0	0.029380	0	0
LINC00969	440993	broad.mit.edu	37	3	195400728	195400728	+	RNA	SNP	A	A	G	rs12107841	by1000genomes	TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr3:195400728A>G	ENST00000445430.1	+	0	1324																											GATTGTGCCCAGCCTGTACGC	0.587000													3	32					0	0	0.004672	0	0
C5orf34	375444	broad.mit.edu	37	5	43503827	43503827	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr5:43503827G>T	ENST00000306862.2	-	5	1343	c.968C>A	c.(967-969)tCt>tAt	p.S323Y	RP11-159F24.3_ENST00000505645.1_RNA	NM_198566.2	NP_940968.1	Q96MH7	CE034_HUMAN	chromosome 5 open reading frame 34	323										breast(2)|endometrium(2)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|stomach(2)	21	Lung NSC(6;2.07e-05)					ATATTCATCAGATTGTCTCTG	0.353000													53	49					2.73381e-35	3.44697e-35	0.048971	1	0
LINC00969	440993	broad.mit.edu	37	3	195404651	195404651	+	RNA	SNP	C	C	G	rs1996904	by1000genomes	TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr3:195404651C>G	ENST00000445430.1	+	0	1508																											TGTCACGAATCTTGACAAATT	0.418000													3	46					0	0	0.004672	0	0
RPS16	6217	broad.mit.edu	37	19	39924009	39924009	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr19:39924009A>G	ENST00000339471.4	-	4	480	c.440T>C	c.(439-441)aTg>aCg	p.M147T	RPS16_ENST00000251453.3_Silent_p.Y115Y|RPS16_ENST00000599539.1_3'UTR|RPS16_ENST00000601655.1_Silent_p.Y98Y			P62249	RS16_HUMAN	ribosomal protein S16	0					endocrine pancreas development|ribosomal small subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome			central_nervous_system(1)|large_intestine(2)|lung(2)|skin(2)	7	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;4.14e-26)|all cancers(26;2.68e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGGTCCGGTCATACTGGATGA	0.537000													17	60					0	0	0.038395	0	0
ASXL3	80816	broad.mit.edu	37	18	31324386	31324386	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr18:31324386C>G	ENST00000269197.5	+	12	4574	c.4574C>G	c.(4573-4575)cCt>cGt	p.P1525R		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1525					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						ATTAGCAGGCCTGAGCCAGTT	0.542000											OREG0024911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	42					0	0	0.029380	0	0
BCRP7	100133163	broad.mit.edu	37	22	18844763	18844763	+	RNA	SNP	T	T	C			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr22:18844763T>C	ENST00000412938.1	+	0	3013																											TCACAGCCTCTGAGGGCAGCA	0.562000													3	15					0	0	0.009096	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887527	12887527	+	Silent	SNP	A	A	G	rs2486716		TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr1:12887527A>G	ENST00000535591.1	-	3	525	c.330T>C	c.(328-330)ttT>ttC	p.F110F		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	110								p.F110F(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						AAAGTTCTACAAACACAGTCA	0.498000													6	366					0	0	0.021553	0	0
PLCB1	23236	broad.mit.edu	37	20	8665706	8665706	+	Silent	SNP	G	G	A			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr20:8665706G>A	ENST00000378641.3	+	10	1465	c.990G>A	c.(988-990)tcG>tcA	p.S330S	PLCB1_ENST00000378637.2_Silent_p.S330S|PLCB1_ENST00000338037.6_Silent_p.S330S	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	330	PI-PLC X-box.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						TTAATTCCTCGCACAACACCT	0.418000													50	65					0	0	0.048971	0	0
ZNF761	388561	broad.mit.edu	37	19	53945837	53945837	+	RNA	SNP	T	T	C	rs17855120	by1000genomes	TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr19:53945837T>C	ENST00000454407.1	+	0	55				TPM3P9_ENST00000424846.3_RNA			Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		GGACCAGACTTTGCTTGACCT	0.512000													3	48					0	0	0.047766	0	0
ITGAD	3681	broad.mit.edu	37	16	31425790	31425790	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr16:31425790T>C	ENST00000389202.2	+	17	2064	c.2015T>C	c.(2014-2016)gTc>gCc	p.V672A		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	672					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						CAAAGCTCTGTCAGGTTTGAT	0.448000													97	93					0	0	0.048971	0	0
HERC2	8924	broad.mit.edu	37	15	28482110	28482110	+	Splice_Site	SNP	G	G	A			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr15:28482110G>A	ENST00000261609.7	-	26	4110	c.4003_splice	c.e26+1	p.A1334_splice		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	1334					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TTTTCTTACTGGCACATTCAA	0.463000													15	19					0	0	0.038395	0	0
POGZ	23126	broad.mit.edu	37	1	151381178	151381179	+	Frame_Shift_Ins	INS	-	-	TGGT			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr1:151381178_151381179insTGGT	ENST00000271715.2	-	13	2366_2367	c.2052_2053insACCA	c.(2050-2055)ccgcacfs	p.H685fs	POGZ_ENST00000368863.2_Frame_Shift_Ins_p.H590fs|POGZ_ENST00000540984.1_Frame_Shift_Ins_p.H47fs|POGZ_ENST00000361398.3_Frame_Shift_Ins_p.H632fs|POGZ_ENST00000531094.1_Frame_Shift_Ins_p.H623fs|POGZ_ENST00000491586.1_Frame_Shift_Ins_p.H641fs|POGZ_ENST00000392723.1_Frame_Shift_Ins_p.H632fs|POGZ_ENST00000409503.1_Frame_Shift_Ins_p.H676fs	NM_001194937.1|NM_015100.3	NP_001181866.1|NP_055915.2	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	685					cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(10)|kidney(3)|large_intestine(10)|liver(2)|lung(11)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	47	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			ACCTTGGTGCCTGGTTTCAAGC	0.450													139	246	---	---	---	---					
OGDH	4967	broad.mit.edu	37	7	44684936	44684936	+	Frame_Shift_Del	DEL	T	T	-			TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr7:44684936delT	ENST00000222673.5	+	3	275	c.233delT	c.(232-234)atfs	p.I78fs	OGDH_ENST00000543843.1_Frame_Shift_Del_p.I18fs|OGDH_ENST00000449767.1_Frame_Shift_Del_p.I78fs|OGDH_ENST00000447398.1_Frame_Shift_Del_p.I78fs|OGDH_ENST00000444676.1_Frame_Shift_Del_p.I78fs|OGDH_ENST00000443864.2_Frame_Shift_Del_p.I78fs|OGDH_ENST00000439616.2_Intron	NM_002541.3	NP_002532.2	Q02218	ODO1_HUMAN	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	78					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding	p.R81fs*19(1)		breast(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	36					NADH(DB00157)	TCATGGGACATTTTTTTTCGC	0.577													7	212	---	---	---	---					
LILRP2	79166	broad.mit.edu	37	19	55221804	55221805	+	RNA	INS	-	-	AC	rs45583536		TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr19:55221804_55221805insAC	ENST00000413439.1	+	0	1415																											CAGAGACAGAGACTGAGGGTCC	0.614													5	4	---	---	---	---					
AC008103.5	0	broad.mit.edu	37	22	18842473	18842473	+	RNA	DEL	G	G	-	rs66618606		TCGA-D3-A1Q9-06A-11D-A19A-08	TCGA-D3-A1Q9-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f968b693-f462-4779-8784-75e12a72953d	1606c5e3-e3d1-4618-8690-7f6e1e36a54b	g.chr22:18842473delG	ENST00000412938.1	+	0	2208																											AGCTGCTGGTGGGGAGGTCTT	0.647													3	4	---	---	---	---