Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
BRAT1	221927	broad.mit.edu	37	7	2583426	2583426	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr7:2583426G>A	uc003smi.3	-	4	889	c.601C>T	c.(601-603)Cac>Tac	p.H201Y	BRAT1_uc003smh.4_5'Flank|BRAT1_uc021zyz.1_Missense_Mutation_p.H26Y|BRAT1_uc003smj.2_Missense_Mutation_p.H201Y	NM_152743	NP_689956	Q6PJG6	BRAT1_HUMAN	Homo sapiens BRCA1-associated ATM activator 1 (BRAT1), mRNA.	201					response to ionizing radiation	nucleus	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23						TCTTCAACGTGATCCATGATC	0.672000														71			20		0	0	0.000586117	0	0
FBXO21	23014	broad.mit.edu	37	12	117593596	117593596	+	Splice_Site	SNP	C	G	G			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr12:117593596C>G	uc001twk.3	-	11	1735	c.1696_splice	c.e11+1	p.E566_splice	FBXO21_uc001twj.3_Splice_Site_p.E559_splice|FBXO21_uc009zwq.3_Splice_Site_p.E499_splice	NM_033624	NP_296373	O94952	FBX21_HUMAN	Homo sapiens F-box protein 21 (FBXO21), transcript variant 1, mRNA.	566					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			breast(4)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|pancreas(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	29	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		CGCCGCTTACCTTGGGCTGCG	0.642000											OREG0022166	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)		25			3		0	0	6.4e-05	0	0
GRIA2	2891	broad.mit.edu	37	4	158224758	158224758	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr4:158224758A>C	uc003ipm.4	+	2	743	c.284A>C	c.(283-285)aAg>aCg	p.K95T	GRIA2_uc011cit.2_Missense_Mutation_p.K48T|GRIA2_uc021xtr.1_Missense_Mutation_p.K95T|GRIA2_uc003ipl.4_Missense_Mutation_p.K95T|GRIA2_uc003ipk.4_Missense_Mutation_p.K48T|GRIA2_uc010iqh.1_Non-coding_Transcript	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	Homo sapiens glutamate receptor, ionotropic, AMPA 2 (GRIA2), transcript variant 2, mRNA.	95					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	TATGACAAGAAGTCTGTAAAT	0.398000														89			45		0	0	0.000125731	0	0
DNAI2	64446	broad.mit.edu	37	17	72278045	72278045	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr17:72278045A>G	uc002jkf.3	+	1	199	c.89A>G	c.(88-90)gAc>gGc	p.D30G	DNAI2_uc002jkg.3_Missense_Mutation_p.D30G|DNAI2_uc010dfp.3_Non-coding_Transcript	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	Homo sapiens dynein, axonemal, intermediate chain 2 (DNAI2), transcript variant 1, mRNA.	30					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(2)|lung(19)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						CTGAACATCGACATCATGCCC	0.602000									Kartagener syndrome					67			22		0	0	0.000175454	0	0
PMM1	5372	broad.mit.edu	37	22	41980568	41980568	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr22:41980568G>A	uc003bal.2	-	2	307	c.245C>T	c.(244-246)aCg>aTg	p.T82M		NM_002676	NP_002667	Q92871	PMM1_HUMAN	Homo sapiens phosphomannomutase 1 (PMM1), mRNA.	82					GDP-mannose biosynthetic process|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	metal ion binding|phosphomannomutase activity			NS(1)|large_intestine(4)|lung(3)|ovary(1)|urinary_tract(2)	11						ATACTGCACCGTCCCGTTCTC	0.547000														151			25		0	0	0.000184323	0	0
FCGBP	8857	broad.mit.edu	37	19	40367841	40367841	+	Silent	SNP	T	G	G			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr19:40367841T>G	uc002omp.4	-	28	13127	c.13119A>C	c.(13117-13119)gcA>gcC	p.A4373A		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Homo sapiens Fc fragment of IgG binding protein (FCGBP), mRNA.	4373	TIL 10.					extracellular region	protein binding	p.A4373A(4)		NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TCGTAAGGGGTGCAGGGGACG	0.627000														24			12		0	0	0.000132079	0	0
PGK2	5232	broad.mit.edu	37	6	49753894	49753894	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr6:49753894C>A	uc003ozu.3	-	0	1160	c.1007G>T	c.(1006-1008)tGg>tTg	p.W336L		NM_138733	NP_620061	P07205	PGK2_HUMAN	Homo sapiens phosphoglycerate kinase 2 (PGK2), mRNA.	336					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity	p.W336*(1)		autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					CGGCCCATTCCAAACAATTAG	0.483000														154			43		2.35958e-20	4.16231e-19	0.000437636	1	0
ANKAR	150709	broad.mit.edu	37	2	190541666	190541666	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr2:190541666T>G	uc002uqw.2	+	1	538	c.450T>G	c.(448-450)atT>atG	p.I150M	ANKAR_uc002uqu.3_Intron|ANKAR_uc002uqv.1_Missense_Mutation_p.I150M	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	Homo sapiens ankyrin and armadillo repeat containing (ANKAR), mRNA.	150						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			TGATCAATATTGACTACATGC	0.388000														41			28		0	0	0.000147802	0	0
GRIN2B	2904	broad.mit.edu	37	12	13761663	13761663	+	Silent	SNP	G	A	A			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr12:13761663G>A	uc001rbt.2	-	8	2063	c.1884C>T	c.(1882-1884)tcC>tcT	p.S628S		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B), mRNA.	628					response to ethanol	N-methyl-D-aspartate selective glutamate receptor complex|cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|glycine binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCATGATCTTGGAGGTGGTCC	0.522000														39			24		0	0	0.000586117	0	0
LOC441666	441666	broad.mit.edu	37	10	42832499	42832499	+	RNA	SNP	C	G	G			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr10:42832499C>G	uc010qey.2	-	2		c.1476G>C								Homo sapiens zinc finger protein 91 pseudogene (LOC441666), non-coding RNA.																		TCTCCCCTATCAATTATGTTT	0.363000														3			3		0	0	6.4e-05	0	0
PDE3A	5139	broad.mit.edu	37	12	20806962	20806962	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr12:20806962T>G	uc001reh.2	+	14	3047	c.3007T>G	c.(3007-3009)Tcc>Gcc	p.S1003A	PDE3A_uc021qwa.1_Missense_Mutation_p.S681A	NM_000921	NP_000912	Q14432	PDE3A_HUMAN	Homo sapiens phosphodiesterase 3A, cGMP-inhibited (PDE3A), transcript variant 1, mRNA.	1003	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CCTTCAGGAATCCTTCATCTC	0.488000														30			35		0	0	0.000491102	0	0
KRT73	319101	broad.mit.edu	37	12	53009977	53009977	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr12:53009977C>T	uc001sas.3	-	1	670	c.635G>A	c.(634-636)cGc>cAc	p.R212H		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	Homo sapiens keratin 73 (KRT73), mRNA.	212	Coil 1B.|Rod.		R -> H (in a colorectal cancer sample; somatic mutation).			keratin filament	structural molecule activity	p.R212H(2)		NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.189)		CACCACTTCGCGCACGCTCCT	0.627000														70			28		0	0	0.000117367	0	0
ANKRD35	148741	broad.mit.edu	37	1	145560097	145560097	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr1:145560097G>A	uc001eob.1	+	7	691	c.583G>A	c.(583-585)Gag>Aag	p.E195K	ANKRD35_uc010oyx.1_Missense_Mutation_p.E38K	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	Homo sapiens ankyrin repeat domain 35 (ANKRD35), mRNA.	195										NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(16)|ovary(4)|prostate(3)|skin(2)|urinary_tract(1)	47	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CCTGGCCTGTGAGAAAGGCAG	0.567000														88			24		0	0	0.000147802	0	0
FMO1	2326	broad.mit.edu	37	1	171250049	171250049	+	Missense_Mutation	SNP	T	C	C	rs150268968	byFrequency	TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr1:171250049T>C	uc009wvz.3	+	5	888	c.752T>C	c.(751-753)aTt>aCt	p.I251T	FMO1_uc010pme.2_Missense_Mutation_p.I188T|FMO1_uc001ghl.3_Missense_Mutation_p.I251T|FMO1_uc001ghm.3_Missense_Mutation_p.I251T	NM_002021	NP_002012	Q01740	FMO1_HUMAN	Homo sapiens flavin containing monooxygenase 1 (FMO1), mRNA.	251					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	NADP binding|flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(2)|skin(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CCAACCCCAATTGTGACTTGG	0.458000														93			25		0	0	0.000117367	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	T	T			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr1:16918653C>T	uc009vos.1	-	6	853	c.-35_splice	c.e6+1		NBPF1_uc010oce.1_Intron	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	Homo sapiens neuroblastoma breakpoint family, member 1 (NBPF1), mRNA.							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000														68			19		0	0	0.000229342	0	0
OR6K2	81448	broad.mit.edu	37	1	158669743	158669743	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr1:158669743C>T	uc001fsu.1	-	0	700	c.700G>A	c.(700-702)Ggc>Agc	p.G234S		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	Homo sapiens olfactory receptor, family 6, subfamily K, member 2 (OR6K2), mRNA.	234					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	46	all_hematologic(112;0.0378)					GTGCGGCGGCCTCCAGCTGAA	0.468000														77			52		0	0	0.000147903	0	0
OR8A1	390275	broad.mit.edu	37	11	124439994	124439994	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr11:124439994C>G	uc010san.2	+	0	30	c.30C>G	c.(28-30)tgC>tgG	p.C10W		NM_001005194	NP_001005194	Q8NGG7	OR8A1_HUMAN	Homo sapiens olfactory receptor, family 8, subfamily A, member 1 (OR8A1), mRNA.	10					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			haematopoietic_and_lymphoid_tissue(1)|lung(16)|ovary(2)|prostate(1)|skin(2)	22		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		TGCATCCCTGCAGGCCTCCCA	0.522000														5			22		0	0	0.000229342	0	0
NOTCH4	4855	broad.mit.edu	37	6	32163258	32163258	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr6:32163258G>A	uc003obb.3	-	29	6107	c.5968C>T	c.(5968-5970)Ctc>Ttc	p.L1990F	GPSM3_uc003oay.4_5'Flank|GPSM3_uc003oaz.3_5'UTR|NOTCH4_uc011dpt.2_3'UTR|NOTCH4_uc003oba.3_Missense_Mutation_p.L650F|NOTCH4_uc011dpu.2_Non-coding_Transcript|NOTCH4_uc011dpv.2_Non-coding_Transcript	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	Homo sapiens notch 4 (NOTCH4), mRNA.	1990					Notch receptor processing|Notch signaling pathway|cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi lumen|cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						ATTTCTTGGAGGGCTGGGGGA	0.522000														221			169		0	0	0.000147903	0	0
CYTIP	9595	broad.mit.edu	37	2	158300486	158300486	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr2:158300486G>A	uc002tzj.1	-	0	119	c.47C>T	c.(46-48)gCg>gTg	p.A16V	CYTIP_uc010zcl.1_Intron	NM_004288	NP_004279	O60759	CYTIP_HUMAN	Homo sapiens cytohesin 1 interacting protein (CYTIP), mRNA.	16					regulation of cell adhesion	cell cortex|early endosome	protein binding			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	15						GCAGAAGTCCGCCAAATTGCC	0.507000														63			41		0	0	0.000589545	0	0
RFX4	5992	broad.mit.edu	37	12	107048024	107048024	+	Silent	SNP	G	A	A			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr12:107048024G>A	uc001tlt.3	+	3	377	c.237G>A	c.(235-237)gaG>gaA	p.E79E	LOC100287944_uc021rdg.1_Intron|RFX4_uc001tlr.3_Silent_p.E70E|RFX4_uc010swv.2_Non-coding_Transcript|RFX4_uc001tls.3_Silent_p.E79E	NM_001206691	NP_001193620	Q33E94	RFX4_HUMAN	Homo sapiens regulatory factor X, 4 (influences HLA class II expression) (RFX4), transcript variant 4, mRNA.	70					transcription, DNA-dependent	nucleus	DNA binding			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(20)|pancreas(1)|upper_aerodigestive_tract(1)	35						AGAACTATGAGATTGCAGAGG	0.488000														47			23		0	0	0.00047179	0	0
ANKRD35	148741	broad.mit.edu	37	1	145558852	145558852	+	Silent	SNP	G	A	A			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr1:145558852G>A	uc001eob.1	+	6	579	c.471G>A	c.(469-471)ctG>ctA	p.L157L	ANKRD35_uc010oyx.1_5'UTR	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	Homo sapiens ankyrin repeat domain 35 (ANKRD35), mRNA.	157										NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(16)|ovary(4)|prostate(3)|skin(2)|urinary_tract(1)	47	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GTACACCCCTGATGATCGCAT	0.582000														208			69		0	0	0.000147903	0	0
FRG1B	284802	broad.mit.edu	37	20	29628299	29628300	+	Missense_Mutation	DNP	AG	GA	GA			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr20:29628299_29628300AG>GA	uc010ztl.1	+	2	243_244	c.211_212AG>GA	c.(211-213)agt>GAt	p.S71D	FRG1B_uc002wvm.1_Non-coding_Transcript|FRG1B_uc010ztj.1_Non-coding_Transcript|FRG1B_uc010gdr.1_Non-coding_Transcript|FRG1B_uc010ztk.1_Missense_Mutation_p.S23D					Homo sapiens FSHD region gene 1 family, member B (FRG1B), non-coding RNA.									p.S101N(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AGAAGCAAAAAGTAAAACAGCA	0.361000														61			4		0	0	6.4e-05	0	0
SIGLEC14	100049587	broad.mit.edu	37	19	52146852	52146853	+	Missense_Mutation	DNP	CC	AT	AT			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr19:52146852_52146853CC>AT	uc002pxf.4	-	5	1205_1206	c.1085_1086GG>AT	c.(1084-1086)agg>aAT	p.R362N		NM_001098612	NP_001092082	Q08ET2	SIG14_HUMAN	Homo sapiens sialic acid binding Ig-like lectin 14 (SIGLEC14), mRNA.	362					cell adhesion	integral to membrane|plasma membrane	protein binding|sugar binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	29		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000965)|OV - Ovarian serous cystadenocarcinoma(262;0.0195)		TGAGAGCCCCCCTGATCAGGGT	0.579000														34			33		0	0	6.4e-05	0	0
TPTE2P6	374491	broad.mit.edu	37	13	25144712	25144712	+	RNA	SNP	A	C	C	rs71218558	by1000genomes	TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr13:25144712A>C	uc001upm.3	+	3		c.253A>C								Homo sapiens transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 6 (TPTE2P6), non-coding RNA.																		TGTGTTTAACACAGCCCCTGC	0.393000														15			3		0	0	0.00024832	0	0
SYNDIG1L	646658	broad.mit.edu	37	14	74874582	74874582	+	Silent	SNP	C	A	A			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr14:74874582C>A	uc001xpx.2	-	2	776	c.528G>T	c.(526-528)ctG>ctT	p.L176L		NM_001105579	NP_001099049	A6NDD5	SYN1L_HUMAN	Homo sapiens synapse differentiation inducing 1-like (SYNDIG1L), mRNA.	176					response to biotic stimulus	Golgi apparatus|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|lung(8)|pancreas(1)|prostate(1)|skin(1)	14						CAGCAATGCCCAGTGGCCAGA	0.592000														35			9		3.86212e-05	0.000642715	3.86212e-05	1	0
NAT9	26151	broad.mit.edu	37	17	72768379	72768379	+	Silent	SNP	G	A	A			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr17:72768379G>A	uc002jlq.3	-	4	446	c.372C>T	c.(370-372)gcC>gcT	p.A124A	NAT9_uc002jlr.3_Silent_p.A123A	NM_015654	NP_056469	Q9BTE0	NAT9_HUMAN	Homo sapiens N-acetyltransferase 9 (GCN5-related, putative) (NAT9), mRNA.	124	N-acetyltransferase.					protein complex	N-acetyltransferase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)	8						TCGCGAGAACGGCCTCAGTGC	0.617000														23			8		0	0	0.000274275	0	0
CCDC66	285331	broad.mit.edu	37	3	56655639	56655639	+	Nonsense_Mutation	SNP	C	A	A			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr3:56655639C>A	uc003dhz.3	+	17	2927	c.2840C>A	c.(2839-2841)tCa>tAa	p.S947*	CCDC66_uc003dhy.3_Nonsense_Mutation_p.S583*|CCDC66_uc003dhu.3_Nonsense_Mutation_p.S913*|CCDC66_uc003dhx.3_Non-coding_Transcript|CCDC66_uc003dia.3_Nonsense_Mutation_p.S315*|FAM208A_uc003dib.4_3'UTR|FAM208A_uc003dic.4_3'UTR|FAM208A_uc003die.4_3'UTR|FAM208A_uc003did.4_3'UTR	NM_001141947	NP_001135419	A2RUB6	CCD66_HUMAN	Homo sapiens coiled-coil domain containing 66 (CCDC66), transcript variant 1, mRNA.	947										breast(1)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(2)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		TTTGGTTCTTCATTTTAAATG	0.348000														119			5		0.000602214	0.00983617	0.000602214	1	0
SYNM	23336	broad.mit.edu	37	15	99669741	99669741	+	Silent	SNP	T	G	G			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr15:99669741T>G	uc002bup.3	+	4	1293	c.1173T>G	c.(1171-1173)ggT>ggG	p.G391G	SYNM_uc002buo.3_Silent_p.G391G|SYNM_uc002buq.3_Intron	NM_145728	NP_663780	O15061	SYNEM_HUMAN	Homo sapiens synemin, intermediate filament protein (SYNM), transcript variant A, mRNA.	392	Tail.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(6)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	29						CTATTGGAGGTGATGCCAGAA	0.522000														146			110		0	0	0.000147903	0	0
HRNR	388697	broad.mit.edu	37	1	152191290	152191290	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr1:152191290C>T	uc001ezt.1	-	2	2891	c.2815G>A	c.(2815-2817)Ggg>Agg	p.G939R		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	Homo sapiens hornerin (HRNR), mRNA.	939					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGGACTGCCCTGAGCTAGAC	0.577000														461			154		0	0	0.000147903	0	0
RPTOR	57521	broad.mit.edu	37	17	78882720	78882720	+	Silent	SNP	C	T	T			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr17:78882720C>T	uc002jyt.1	+	20	3316	c.2511C>T	c.(2509-2511)atC>atT	p.I837I	RPTOR_uc010wug.1_Silent_p.I679I	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	Homo sapiens regulatory associated protein of MTOR, complex 1 (RPTOR), transcript variant 1, mRNA.	837					TOR signaling cascade|cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of TOR signaling cascade|positive regulation of protein serine/threonine kinase activity	TORC1 complex|cytosol|lysosome	protein complex binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(3)	44						TCAACAGCATCGCCTACAAGG	0.582000														56			91		0	0	0.000147903	0	0
DLGAP2	9228	broad.mit.edu	37	8	1497675	1497675	+	Silent	SNP	G	A	A			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr8:1497675G>A	uc003wpl.3	+	1	913	c.816G>A	c.(814-816)tcG>tcA	p.S272S	DLGAP2_uc003wpm.3_Silent_p.S272S	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	Homo sapiens discs, large (Drosophila) homolog-associated protein 2 (DLGAP2), mRNA.	351					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		TCAAGTGCTCGGCCTGTGAGG	0.662000														33			32		0	0	0.000279167	0	0
POTEE	445582	broad.mit.edu	37	2	132021477	132021477	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr2:132021477G>A	uc002tsn.2	+	14	2501	c.2449G>A	c.(2449-2451)Gag>Aag	p.E817K	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Missense_Mutation_p.E417K|POTEE_uc002tsl.2_Missense_Mutation_p.E399K|POTEE_uc010fmy.1_Missense_Mutation_p.E281K	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	Homo sapiens POTE ankyrin domain family, member E (POTEE), mRNA.	817	Actin-like.						ATP binding										GGCCAACCGCGAGAAGATGAC	0.612000														122			40		0	0	0.000147903	0	0
CD163L1	283316	broad.mit.edu	37	12	7528424	7528424	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr12:7528424C>T	uc010sge.2	-	9	2614	c.2588G>A	c.(2587-2589)gGg>gAg	p.G863E	CD163L1_uc001qsy.3_Missense_Mutation_p.G853E	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	Homo sapiens CD163 molecule-like 1 (CD163L1), mRNA.	853	SRCR 8.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						TAGACCATTCCCTTTTCCAAA	0.448000														25			40		0	0	0.000191422	0	0
TPTE2P6	374491	broad.mit.edu	37	13	25144710	25144710	+	RNA	SNP	A	G	G	rs71218558	by1000genomes	TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr13:25144710A>G	uc001upm.3	+	3		c.251A>G								Homo sapiens transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 6 (TPTE2P6), non-coding RNA.																		GATGTGTTTAACACAGCCCCT	0.398000														15			3		0	0	6.4e-05	0	0
MYH2	4620	broad.mit.edu	37	17	10428344	10428344	+	Silent	SNP	G	A	A			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr17:10428344G>A	uc010coi.3	-	33	4829	c.4701C>T	c.(4699-4701)atC>atT	p.I1567I	AK097500_uc002gml.1_Intron|MYH2_uc002gmp.4_Silent_p.I1567I|MYH2_uc010coj.3_Intron	NM_001100112	NP_060004	Q9UKX2	MYH2_HUMAN	Homo sapiens myosin, heavy chain 2, skeletal muscle, adult (MYH2), transcript variant 2, mRNA.	1567					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	ATP binding|actin binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						ACTCAAGCTGGATGCGCAGGA	0.418000														3			76		0	0	0.000147903	0	0
CARKD	55739	broad.mit.edu	37	13	111289537	111289537	+	Silent	SNP	G	A	A			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr13:111289537G>A	uc001vrc.3	+	8	925	c.834G>A	c.(832-834)tcG>tcA	p.S278S	CARKD_uc010tjj.2_Silent_p.S260S|CARKD_uc001vqz.3_Non-coding_Transcript|CARKD_uc001vra.3_Non-coding_Transcript|CARKD_uc010tjk.2_Silent_p.S168S|CARKD_uc010tjl.2_Silent_p.S147S|CARKD_uc001vrb.3_Silent_p.S278S|CARKD_uc021rmn.1_Silent_p.S57S	NM_018210	NP_060680	Q8IW45	CARKD_HUMAN	Homo sapiens carbohydrate kinase domain containing (CARKD), transcript variant 1, mRNA.	278	YjeF C-terminal.									NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)	15						ACCTCCTGTCGGGCTCCCTGG	0.587000														25			17		0	0	0.000566183	0	0
APPL2	55198	broad.mit.edu	37	12	105589120	105589120	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr12:105589120G>A	uc010swu.1	-	13	1396	c.1178C>T	c.(1177-1179)gCg>gTg	p.A393V	APPL2_uc010swt.2_Missense_Mutation_p.A344V|APPL2_uc001tlf.1_Missense_Mutation_p.A387V|APPL2_uc001tlg.1_Missense_Mutation_p.A141V|APPL2_uc009zuq.3_Missense_Mutation_p.A344V	NM_001251904	NP_001238833	Q8NEU8	DP13B_HUMAN	Homo sapiens adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (APPL2), transcript variant 2, mRNA.	387	Required for RAB5A binding (By similarity).				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						CAACTTGATCGCGACTGCCTA	0.473000														25			12		0	0	6.40141e-05	0	0
PTGER4	5734	broad.mit.edu	37	5	40691977	40691977	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr5:40691977C>A	uc003jlz.3	+	2	1556	c.964C>A	c.(964-966)Ccc>Acc	p.P322T		NM_000958	NP_000949	P35408	PE2R4_HUMAN	Homo sapiens prostaglandin E receptor 4 (subtype EP4) (PTGER4), mRNA.	322					G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			breast(1)|endometrium(3)|liver(1)|lung(13)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23						TTCTGTGAACCCCATCCTAGA	0.483000														48			27		8.53417e-09	1.44753e-07	0.000491102	1	0
ZNF804A	91752	broad.mit.edu	37	2	185798353	185798353	+	Silent	SNP	G	A	A			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr2:185798353G>A	uc002uph.3	+	2	873	c.279G>A	c.(277-279)agG>agA	p.R93R		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	Homo sapiens zinc finger protein 804A (ZNF804A), mRNA.	93						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TGAAACAAAGGGAATTTGCTC	0.353000														39			29		0	0	0.000279167	0	0
DENND1B	163486	broad.mit.edu	37	1	197509108	197509108	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr1:197509108G>A	uc021pgu.1	-	19	1839	c.1501C>T	c.(1501-1503)Cgt>Tgt	p.R501C	DENND1B_uc010ppf.2_Non-coding_Transcript	NM_001195215	NP_001182144	Q6P3S1	DEN1B_HUMAN	Homo sapiens DENN/MADD domain containing 1B (DENND1B), transcript variant 3, mRNA.	0						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			NS(2)|breast(2)|kidney(2)|large_intestine(3)|lung(12)|upper_aerodigestive_tract(1)	22						GCAAGCTTACGCTTTTCTGAG	0.348000														93			10		0	0	0.000442599	0	0
GBF1	8729	broad.mit.edu	37	10	104120107	104120107	+	Silent	SNP	C	T	T			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr10:104120107C>T	uc001kux.2	+	11	1638	c.1344C>T	c.(1342-1344)acC>acT	p.T448T	GBF1_uc001kuw.3_3'UTR|GBF1_uc001kuy.2_Silent_p.T448T|GBF1_uc001kuz.2_Silent_p.T449T	NM_004193	NP_004184	Q92538	GBF1_HUMAN	Homo sapiens golgi brefeldin A resistant guanine nucleotide exchange factor 1 (GBF1), transcript variant 1, mRNA.	448					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(14)|kidney(8)|large_intestine(15)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	71		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		AGTGCCAGACCCTCTTGGGCC	0.537000														59			42		0	0	0.000437636	0	0
DGKD	8527	broad.mit.edu	37	2	234368894	234368894	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr2:234368894C>G	uc002vui.1	+	23	2896	c.2884C>G	c.(2884-2886)Cgc>Ggc	p.R962G	DGKD_uc002vuj.1_Missense_Mutation_p.R918G|DGKD_uc010fyi.1_Non-coding_Transcript	NM_152879	NP_690618	Q16760	DGKD_HUMAN	Homo sapiens diacylglycerol kinase, delta 130kDa (DGKD), transcript variant 2, mRNA.	962					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(13)|lung(15)|ovary(1)|pancreas(1)|skin(1)	38		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	CGAGCTGCCCCGCCCTCCATC	0.597000														47			25		0	0	0.000586117	0	0
NRAS	4893	broad.mit.edu	37	1	115256529	115256529	+	Missense_Mutation	SNP	T	C	C	rs11554290		TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr1:115256529T>C	uc009wgu.3	-	2	436	c.182A>G	c.(181-183)cAa>cGa	p.Q61R		NM_002524	NP_002515	P01111	RASN_HUMAN	Homo sapiens neuroblastoma RAS viral (v-ras) oncogene homolog (NRAS), mRNA.	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		Ras protein signal transduction|activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(1713)|p.Q61K(635)|p.Q61L(370)|p.Q61H(123)|p.Q61P(46)|p.Q61E(9)|p.G60E(6)|p.Q61?(5)|p.Q61Q(3)|p.G60R(1)|p.G60>?(1)|p.Q61*(1)|p.Q61_E62>HK(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458000	Q61L(C3A_LIVER)|Q61L(HEPG2_LIVER)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MELJUSO_SKIN)|Q61L(MHHES1_BONE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(HT1197_URINARY_TRACT)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(KU1919_URINARY_TRACT)|Q61R(NCIH2347_LUNG)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(SKMEL2_SKIN)|Q61R(SW1271_LUNG)|Q61R(TT2609C02_THYROID)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)				38			79		0	0	0.000147903	0	0
STX6	10228	broad.mit.edu	37	1	180957437	180957437	+	Silent	SNP	G	A	A			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr1:180957437G>A	uc021pfr.1	-	5	771	c.534C>T	c.(532-534)ggC>ggT	p.G178G	STX6_uc010pnr.2_Silent_p.G77G	NM_005819	NP_005810	O43752	STX6_HUMAN	Homo sapiens syntaxin 6 (STX6), mRNA.	178	t-SNARE coiled-coil homology.				Golgi vesicle transport|intracellular protein transport|vesicle fusion	clathrin-coated vesicle|early endosome|integral to membrane|perinuclear region of cytoplasm|plasma membrane|trans-Golgi network membrane	SNAP receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	10						CCCCGATGCTGCCAGAGACCA	0.517000														119			41		0	0	0.000374591	0	0
PTPN14	5784	broad.mit.edu	37	1	214557049	214557051	+	In_Frame_Del	DEL	CCT	-	-			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr1:214557049_214557051delCCT	uc001hkk.2	-	12	2800_2802	c.2147_2149delAGG	c.(2146-2151)gaggct>gct	p.E716del	PTPN14_uc021piy.1_In_Frame_Del_p.E480del|PTPN14_uc010pty.2_In_Frame_Del_p.E617del	NM_005401	NP_005392	Q15678	PTN14_HUMAN	Homo sapiens protein tyrosine phosphatase, non-receptor type 14 (PTPN14), mRNA.	716	Poly-Glu.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding	p.E716delE(2)		NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		GATTCTGGAGCCTCCTCCTCCTC	0.626													---	100	---	---	7	---					
LOC441666	441666	broad.mit.edu	37	10	42832502	42832503	+	RNA	INS	-	TATCA	TATCA			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr10:42832502_42832503insTATCA	uc010qey.2	-	2		c.1472_1473insTGATA								Homo sapiens zinc finger protein 91 pseudogene (LOC441666), non-coding RNA.																		CCCCTATCAATTATGTTTAGTA	0.366													---	4	---	---	2	---					
PKD1P1	339044	broad.mit.edu	37	16	16415262	16415264	+	RNA	DEL	GTG	-	-			TCGA-FS-A1ZY-06A-11D-A197-08	TCGA-FS-A1ZY-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c06caf8-b204-4030-9e44-26fda5232e1d	416e6d70-b904-473f-ad36-f94d8ad3cc2b	g.chr16:16415262_16415264delGTG	uc002der.3	+	0		c.754_756delGTG								Homo sapiens polycystic kidney disease 1 (autosomal dominant) pseudogene 1 (PKD1P1), non-coding RNA.																		GGGAGTCCCAGTGGTGAGTATGG	0.714													---	4	---	---	2	---