Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ELK3	2004	broad.mit.edu	37	12	96653537	96653537	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr12:96653537G>A	uc001teo.1	+	3	1310	c.1031G>A	c.(1030-1032)aGt>aAt	p.S344N		NM_005230	NP_005221	P41970	ELK3_HUMAN	Homo sapiens ELK3, ETS-domain protein (SRF accessory protein 2) (ELK3), mRNA.	344					negative regulation of transcription, DNA-dependent|signal transduction	mitochondrion	protein binding|purine-rich negative regulatory element binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity	p.P343L(1)		breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(5)|ovary(2)|prostate(1)|stomach(2)	20	all_cancers(2;0.00173)					CTGACTCCGAGTCCACTGCTC	0.527000														74			38		0	0	0.004289	0	0
DDX20	11218	broad.mit.edu	37	1	112308358	112308358	+	Splice_Site	SNP	G	A	A			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr1:112308358G>A	uc001ebs.3	+	11	1670	c.1313_splice	c.e11-1	p.D438_splice	DDX20_uc010owf.2_Splice_Site_p.D200_splice|DDX20_uc001ebt.3_Splice_Site_p.D46_splice	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 (DDX20), mRNA.	438	Helicase C-terminal.				assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding	p.?(1)		endometrium(3)|kidney(7)|large_intestine(6)|lung(3)|pancreas(1)|prostate(1)	21		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTTTTATGTAGATCCCATTCC	0.348000														107			61		0	0	0.003610	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37729629	37729629	+	Silent	SNP	G	A	A			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr8:37729629G>A	uc003xkm.2	-	3	2747	c.2691C>T	c.(2689-2691)gtC>gtT	p.V897V	RAB11FIP1_uc003xkn.2_Intron|RAB11FIP1_uc003xkl.2_Silent_p.V226V|RAB11FIP1_uc003xko.1_Silent_p.V226V|RAB11FIP1_uc003xkp.1_Intron	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	Homo sapiens RAB11 family interacting protein 1 (class I) (RAB11FIP1), transcript variant 3, mRNA.	897					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding	p.V897V(2)		NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			CACTCATGGGGACTTCGGAGA	0.597000														59			21		0	0	0.001523	0	0
ZNF609	23060	broad.mit.edu	37	15	64792343	64792343	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr15:64792343T>C	uc002ann.3	+	0	725	c.725T>C	c.(724-726)cTa>cCa	p.L242P	ZNF609_uc010bgy.3_Missense_Mutation_p.L242P	NM_015042	NP_055857	O15014	ZN609_HUMAN	Homo sapiens zinc finger protein 609 (ZNF609), mRNA.	242						nucleus	zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TGTCGCCTGCTAAAGAAAGTC	0.517000														31			11		0	0	0.000673	0	0
BSN	8927	broad.mit.edu	37	3	49690423	49690423	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr3:49690423G>A	uc003cxe.4	+	4	3548	c.3434G>A	c.(3433-3435)cGg>cAg	p.R1145Q		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	Homo sapiens bassoon (presynaptic cytomatrix protein) (BSN), mRNA.	1145					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GGCCCTAGCCGGCTTTACAAG	0.612000														66			13		0	0	0.001855	0	0
EDN3	1908	broad.mit.edu	37	20	57896118	57896118	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr20:57896118G>A	uc002yap.3	+	2	781	c.412G>A	c.(412-414)Ggc>Agc	p.G138S	EDN3_uc002yao.1_Missense_Mutation_p.G138S|EDN3_uc002yaq.3_Missense_Mutation_p.G138S|EDN3_uc002yar.3_Missense_Mutation_p.G138S|EDN3_uc002yas.3_Missense_Mutation_p.G138S	NM_000114	NP_996917	P14138	EDN3_HUMAN	Homo sapiens endothelin 3 (EDN3), transcript variant 1, mRNA.	138					cell surface receptor linked signaling pathway|inositol phosphate-mediated signaling|neutrophil chemotaxis|peptide hormone secretion|positive regulation of MAP kinase activity|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of leukocyte chemotaxis|positive regulation of mitosis|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	extracellular space|soluble fraction	endothelin B receptor binding|hormone activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	19	all_lung(29;0.0115)					AAGCTTCCGGGGCAAGAGGTC	0.597000														77			32		0	0	0.003271	0	0
HMCN1	83872	broad.mit.edu	37	1	185704142	185704142	+	Silent	SNP	T	A	A			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr1:185704142T>A	uc001grq.1	+	0	460	c.231T>A	c.(229-231)ccT>ccA	p.P77P		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	Homo sapiens hemicentin 1 (HMCN1), mRNA.	77	VWFA.				response to stimulus|visual perception	basement membrane	calcium ion binding	p.R76K(1)|p.P77T(1)		NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CTAAAAGACCTCTTTTCAACT	0.368000														81			34		0	0	0.004878	0	0
MYO15A	51168	broad.mit.edu	37	17	18023082	18023082	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr17:18023082C>T	uc021trm.1	+	0	1187	c.968C>T	c.(967-969)tCg>tTg	p.S323L	MYO15A_uc021trl.1_Missense_Mutation_p.S323L	NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	Homo sapiens myosin XVA (MYO15A), mRNA.	323	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	ATP binding|actin binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					TCGGGGTACTCGTCTCCTTAC	0.607000														68			21		0	0	0.001882	0	0
FAM217A	222826	broad.mit.edu	37	6	4069856	4069856	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr6:4069856C>T	uc003mvx.3	-	6	1007	c.601G>A	c.(601-603)Gat>Aat	p.D201N	FAM217A_uc010jnq.1_Intron|FAM217A_uc003mvy.3_Missense_Mutation_p.D138N	NM_173563	NP_775834	Q8IXS0	CF146_HUMAN	Homo sapiens chromosome 6 open reading frame 146 (C6orf146), mRNA.	201																	TCACTTTCATCTGTGAAATTT	0.323000														103			34		0	0	0.002445	0	0
AMZ2P1	201283	broad.mit.edu	37	17	62968690	62968690	+	RNA	SNP	A	G	G	rs138671696	by1000genomes	TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr17:62968690A>G	uc002jez.3	-	3		c.641T>C			AMZ2P1_uc002jfa.3_Non-coding_Transcript|AMZ2P1_uc002jfb.3_Non-coding_Transcript|AMZ2P1_uc010del.2_Non-coding_Transcript					Homo sapiens archaelysin family metallopeptidase 2 pseudogene 1 (AMZ2P1), non-coding RNA.																		AAAATTCCACAAGTCTCTTGG	0.373000														119			5		0	0	0.000602	0	0
SAMSN1	64092	broad.mit.edu	37	21	15884826	15884826	+	Silent	SNP	C	T	T			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr21:15884826C>T	uc002yju.1	-	3	430	c.348G>A	c.(346-348)gaG>gaA	p.E116E	SAMSN1_uc010gky.1_Intron|SAMSN1_uc002yjv.1_Silent_p.E184E	NM_022136	NP_071419	Q9NSI8	SAMN1_HUMAN	Homo sapiens SAM domain, SH3 domain and nuclear localization signals 1 (SAMSN1), transcript variant 1, mRNA.	116					negative regulation of B cell activation|negative regulation of adaptive immune response|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	24				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		GGGACACCTTCTCTGTGTGGG	0.478000														144			61		0	0	0.003610	0	0
CHI3L2	1117	broad.mit.edu	37	1	111773481	111773481	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr1:111773481T>G	uc001eam.3	+	2	259	c.188T>G	c.(187-189)tTc>tGc	p.F63C	CHI3L2_uc001ean.3_Missense_Mutation_p.F53C|CHI3L2_uc001eao.3_5'UTR	NM_004000	NP_001020370	Q15782	CH3L2_HUMAN	Homo sapiens chitinase 3-like 2 (CHI3L2), transcript variant 1, mRNA.	63					chitin catabolic process	extracellular space	cation binding|chitinase activity	p.F63F(2)		breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(8)|prostate(1)	19		all_cancers(81;1.89e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0171)|Colorectal(144;0.0387)|all cancers(265;0.0464)|LUSC - Lung squamous cell carcinoma(189;0.0872)|Epithelial(280;0.0994)|COAD - Colon adenocarcinoma(174;0.141)		ATCTATTCATTCGCCAGCATC	0.463000														47			23		0	0	0.002299	0	0
CDH11	1009	broad.mit.edu	37	16	64984722	64984722	+	Silent	SNP	G	T	T			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr16:64984722G>T	uc002eoi.3	-	11	2276	c.1842C>A	c.(1840-1842)ggC>ggA	p.G614G	CDH11_uc010cdn.3_Non-coding_Transcript|CDH11_uc002eoj.3_Silent_p.G614G|CDH11_uc010vin.2_Silent_p.G488G	NM_001797	NP_001788	P55287	CAD11_HUMAN	Homo sapiens cadherin 11, type 2, OB-cadherin (osteoblast) (CDH11), mRNA.	614					adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		CTGTGCTCAGGCCGGCGTTCA	0.627000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)				53			18		1.56452e-12	8.76673e-12	0.000958	1	0
DUXA	503835	broad.mit.edu	37	19	57666725	57666725	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr19:57666725G>A	uc002qoa.1	-	4	499	c.454C>T	c.(454-456)Cga>Tga	p.R152*		NM_001012729	NP_001012747	A6NLW8	DUXA_HUMAN	Homo sapiens double homeobox A (DUXA), mRNA.	152						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	17		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		CTAGATCTTCGATTTTGGAAC	0.383000														58			12		0	0	0.000978	0	0
SORCS1	114815	broad.mit.edu	37	10	108389146	108389146	+	Splice_Site	SNP	C	A	A			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr10:108389146C>A	uc001kyl.3	-	19	2658	c.2476_splice	c.e19-1	p.G826_splice	SORCS1_uc021pxw.1_Splice_Site_p.G826_splice|SORCS1_uc009xxs.3_Splice_Site_p.G826_splice|SORCS1_uc001kym.3_Splice_Site_p.G826_splice|SORCS1_uc001kyn.2_Splice_Site_p.G826_splice|SORCS1_uc001kyo.3_Splice_Site_p.G826_splice	NM_001013031	NP_001013049	Q8WY21	SORC1_HUMAN	Homo sapiens sortilin-related VPS10 domain containing receptor 1 (SORCS1), transcript variant 2, mRNA.	826	PKD.					integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TGAACATCACCCTGAAAAACA	0.517000														11			13		1.49906e-05	8.1199e-05	0.002450	1	0
TC2N	123036	broad.mit.edu	37	14	92251698	92251698	+	Silent	SNP	G	A	A			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr14:92251698G>A	uc001xzu.4	-	10	1361	c.1170C>T	c.(1168-1170)ttC>ttT	p.F390F	TC2N_uc001xzt.4_Silent_p.F390F|TC2N_uc010auc.3_Silent_p.F326F|TC2N_uc001xzv.4_Silent_p.F390F	NM_001128595	NP_689545	Q8N9U0	TAC2N_HUMAN	Homo sapiens tandem C2 domains, nuclear (TC2N), transcript variant 2, mRNA.	390	C2.					nucleus				breast(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(5)|skin(1)|upper_aerodigestive_tract(2)	18				COAD - Colon adenocarcinoma(157;0.218)		CCACCTTCACGAAAAAACCTA	0.323000														121			48		0	0	0.003214	0	0
SORBS2	8470	broad.mit.edu	37	4	186545335	186545335	+	Silent	SNP	C	T	T			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr4:186545335C>T	uc003iyg.3	-	12	1610	c.1578G>A	c.(1576-1578)gaG>gaA	p.E526E	SORBS2_uc003iyh.3_Intron|SORBS2_uc011ckw.2_Intron|SORBS2_uc003iyi.3_Intron|SORBS2_uc011ckx.2_Intron|SORBS2_uc003iyk.3_Intron|SORBS2_uc003iym.3_Silent_p.E512E|SORBS2_uc003iyl.3_Silent_p.E412E|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.2_Intron|SORBS2_uc011ckv.2_Silent_p.E316E|SORBS2_uc003iyd.3_Intron|SORBS2_uc003iye.3_Intron|SORBS2_uc003iya.3_Intron|SORBS2_uc003iyb.3_Intron|SORBS2_uc003iyc.3_Intron|SORBS2_uc003iyf.3_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	Homo sapiens sorbin and SH3 domain containing 2 (SORBS2), transcript variant 2, mRNA.	412						Z disc|actin cytoskeleton|nucleus|perinuclear region of cytoplasm	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		CCTTGGAGTCCTCCTCACATA	0.592000														67			17		0	0	0.004007	0	0
PLXNA1	5361	broad.mit.edu	37	3	126707544	126707544	+	Silent	SNP	T	G	G			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr3:126707544T>G	uc003ejg.3	+	0	108	c.108T>G	c.(106-108)ggT>ggG	p.G36G		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	Homo sapiens plexin A1 (PLXNA1), mRNA.	36	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity	p.G13G(4)		breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		CAGGCGGGGGTTCACAGCCCC	0.682000														35			11		0	0	0.002299	0	0
MOB2	81532	broad.mit.edu	37	11	1491656	1491656	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr11:1491656C>T	uc010qwz.2	-	4	715	c.553G>A	c.(553-555)Gtg>Atg	p.V185M	MOB2_uc001ltq.2_Missense_Mutation_p.V148M|MOB2_uc001lto.2_Missense_Mutation_p.V69M|MOB2_uc001ltp.1_5'UTR	NM_001172223	NP_001165694	Q70IA6	MOB2_HUMAN	Homo sapiens MOB kinase activator 2 (MOB2), transcript variant 1, mRNA.	154						nucleus|perinuclear region of cytoplasm	metal ion binding			breast(1)|kidney(2)|lung(1)	4						TGTGCCAGCACGTGGAACAGG	0.582000														27			18		0	0	0.006122	0	0
DPP6	1804	broad.mit.edu	37	7	154143335	154143335	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr7:154143335A>G	uc003wlk.3	+	1	409	c.280A>G	c.(280-282)Aaa>Gaa	p.K94E	DPP6_uc003wli.3_Missense_Mutation_p.K30E|DPP6_uc003wlj.3_Missense_Mutation_p.K94E|DPP6_uc010lqh.1_Missense_Mutation_p.K32E|DPP6_uc003wlm.3_Missense_Mutation_p.K32E|DPP6_uc011kvq.2_Missense_Mutation_p.K32E	NM_130797	NP_570629	P42658	DPP6_HUMAN	Homo sapiens dipeptidyl-peptidase 6 (DPP6), transcript variant 1, mRNA.	94					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			GAGGAATTGGAAAGGAATAGC	0.428000														85			29		0	0	0.002836	0	0
SPPL2A	84888	broad.mit.edu	37	15	51012138	51012138	+	Splice_Site	SNP	T	A	A			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr15:51012138T>A	uc001zyv.3	-	14	1668	c.1488_splice	c.e14+1	p.Q496_splice		NM_032802	NP_116191	Q8TCT8	PSL2_HUMAN	Homo sapiens signal peptide peptidase-like 2A (SPPL2A), mRNA.	496						integral to membrane	aspartic-type endopeptidase activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	15				all cancers(107;0.000712)|GBM - Glioblastoma multiforme(94;0.00314)		AGCACATACCTGATAGCTGTT	0.398000														48			14		0	0	0.001855	0	0
UNC45A	55898	broad.mit.edu	37	15	91496480	91496480	+	Silent	SNP	C	T	T			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr15:91496480C>T	uc002bqg.3	+	18	2857	c.2517C>T	c.(2515-2517)gcC>gcT	p.A839A	UNC45A_uc002bqd.3_Silent_p.A824A|UNC45A_uc010uqr.2_Silent_p.A231A|UNC45A_uc021suj.1_Silent_p.A117A|RCCD1_uc002bqj.3_5'Flank|RCCD1_uc002bqk.3_5'Flank	NM_018671	NP_061141	Q9H3U1	UN45A_HUMAN	Homo sapiens unc-45 homolog A (C. elegans) (UNC45A), transcript variant 2, mRNA.	839					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			GGGCAGCTGCCGGGGGCTTGG	0.632000														314			35		0	0	0.003755	0	0
CR1	1378	broad.mit.edu	37	1	207758161	207758161	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr1:207758161C>T	uc001hfy.3	+	24	4260	c.4120C>T	c.(4120-4122)Cct>Tct	p.P1374S	CR1_uc009xcl.1_Missense_Mutation_p.P924S|CR1_uc001hfx.3_Missense_Mutation_p.P1824S|CR1_uc021pij.1_Missense_Mutation_p.P1374S	NM_000573	NP_000564	P17927	CR1_HUMAN	Homo sapiens complement component (3b/4b) receptor 1 (Knops blood group) (CR1), transcript variant F, mRNA.	1374	Sushi 21.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity	p.R1374S(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CACAAGTGACCCTCATGGGAA	0.512000														217			7		0	0	0.001984	0	0
C20orf166-AS1	253868	broad.mit.edu	37	20	61143603	61143603	+	RNA	SNP	G	A	A			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr20:61143603G>A	uc021wfy.1	-	0		c.280C>T			C20orf166-AS1_uc002ycy.3_Non-coding_Transcript|C20orf166-AS1_uc002ycz.2_Non-coding_Transcript					Homo sapiens chromosome 20 open reading frame 200, mRNA (cDNA clone MGC:120891 IMAGE:7939701), complete cds.																		GGGGGCTAAGGGGCCACTTGG	0.652000														56			18		0	0	0.004990	0	0
DNAH8	1769	broad.mit.edu	37	6	38830108	38830108	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr6:38830108G>A	uc021yzh.1	+	43	6293	c.6184G>A	c.(6184-6186)Gca>Aca	p.A2062T	DNAH8_uc003ooe.2_Missense_Mutation_p.A1845T	NM_001206927	NP_001193856			Homo sapiens dynein, axonemal, heavy chain 8 (DNAH8), mRNA.											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AGGTGCTCCCGCAGGACCTGC	0.458000														79			38		0	0	0.004878	0	0
TNS1	7145	broad.mit.edu	37	2	218757693	218757693	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr2:218757693G>A	uc002vgt.2	-	8	783	c.385C>T	c.(385-387)Cac>Tac	p.H129Y	TNS1_uc002vgr.2_Missense_Mutation_p.H129Y|TNS1_uc002vgs.2_Missense_Mutation_p.H129Y|TNS1_uc010zjv.1_Missense_Mutation_p.H129Y|TNS1_uc010fvj.1_Missense_Mutation_p.H197Y|TNS1_uc010fvk.1_Missense_Mutation_p.H254Y|TNS1_uc002vgu.3_Missense_Mutation_p.H160Y	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	Homo sapiens tensin 1 (TNS1), mRNA.	129	Phosphatase tensin-type.					cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TTGCTGTAGTGCATGTAAGCC	0.542000														82			25		0	0	0.005443	0	0
C1QC	714	broad.mit.edu	37	1	22973839	22973839	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr1:22973839C>T	uc001bgc.4	+	2	404	c.301C>T	c.(301-303)Ccc>Tcc	p.P101S	C1QC_uc001bga.4_Missense_Mutation_p.P101S	NM_172369	NP_758957	P02747	C1QC_HUMAN	Homo sapiens complement component 1, q subcomponent, C chain (C1QC), transcript variant 2, mRNA.	101	Collagen-like.				complement activation, classical pathway|innate immune response|negative regulation of granulocyte differentiation|negative regulation of macrophage differentiation	collagen		p.P101P(1)		endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	15		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.21e-27)|Colorectal(126;1.5e-07)|COAD - Colon adenocarcinoma(152;1.12e-05)|GBM - Glioblastoma multiforme(114;1.61e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000538)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.196)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GGTGCCCGGCCCCATGGGCAT	0.642000														59			30		0	0	0.001512	0	0
RBM33	155435	broad.mit.edu	37	7	155530778	155530778	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr7:155530778G>A	uc010lqk.1	+	10	1786	c.1418G>A	c.(1417-1419)aGc>aAc	p.S473N	RBM33_uc011kvv.1_Missense_Mutation_p.S282N	NM_053043	NP_444271	Q96EV2	RBM33_HUMAN	Homo sapiens RNA binding motif protein 33 (RBM33), mRNA.	473	Pro-rich.						RNA binding|nucleotide binding			breast(3)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	27	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		AGATTCCCGAGCCATCTTTTT	0.468000														116			40		0	0	0.001951	0	0
BAGE1	0	broad.mit.edu	37	GL000237.1	2582	2582	+	RNA	SNP	C	T	T			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chrGL000237.1:2582C>T	uc011mgu.1	-	0		c.105G>A								Homo sapiens B melanoma antigen variant f (BAGE1) mRNA, complete cds, alternatively spliced.																		cagagcgagacgagccacggt	0.607000														6			3		0	0	0.004672	0	0
LCLAT1	253558	broad.mit.edu	37	2	30785013	30785013	+	Splice_Site	SNP	T	C	C			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr2:30785013T>C	uc002rnj.3	+	5	688	c.479_splice	c.e5-1	p.G160_splice	LCLAT1_uc010ymp.2_Splice_Site|LCLAT1_uc002rnk.1_Splice_Site_p.G160_splice|LCLAT1_uc002rnl.3_Splice_Site_p.G122_splice|LCLAT1_uc010ymq.2_Splice_Site_p.G122_splice	NM_182551	NP_001002257	Q6UWP7	LCLT1_HUMAN	Homo sapiens lysocardiolipin acyltransferase 1 (LCLAT1), transcript variant 1, mRNA.	160					multicellular organismal development|phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)	19						TGATTCTAGGTTGGGCCATGC	0.313000														28			9		0	0	0.000443	0	0
IPO5	3843	broad.mit.edu	37	13	98645421	98645421	+	Silent	SNP	C	A	A			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr13:98645421C>A	uc001vne.3	+	10	1089	c.909C>A	c.(907-909)acC>acA	p.T303T	IPO5_uc001vnf.1_Silent_p.T285T|IPO5_uc010tik.1_Silent_p.T160T|IPO5_uc010til.1_Silent_p.T225T	NM_002271	NP_002262	O00410	IPO5_HUMAN	Homo sapiens importin 5 (IPO5), mRNA.	285					NLS-bearing substrate import into nucleus|interspecies interaction between organisms|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|Ran GTPase binding|protein transporter activity			breast(2)|endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	27						TGATCGTCACCCTCTCTGAGA	0.388000														26			16		2.23348e-06	1.23031e-05	0.004007	1	0
PPP6C	5537	broad.mit.edu	37	9	127912061	127912061	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr9:127912061G>A	uc010mwv.3	-	7	1141	c.920C>T	c.(919-921)tCg>tTg	p.S307L	PPP6C_uc004bpg.4_Missense_Mutation_p.S270L|PPP6C_uc010mww.3_Missense_Mutation_p.S248L|PPP6C_uc011lzr.2_Missense_Mutation_p.S123L	NM_001123355	NP_001116827	O00743	PPP6_HUMAN	Homo sapiens protein phosphatase 6, catalytic subunit (PPP6C), transcript variant 1, mRNA.	270					G1/S transition of mitotic cell cycle|protein dephosphorylation	cytosol	metal ion binding|protein binding|protein serine/threonine phosphatase activity	p.S270L(1)		NS(2)|endometrium(1)|large_intestine(4)|liver(1)|lung(2)|ovary(1)|skin(3)	14						GACCATGATCGAAGCAATATT	0.408000														19			35		0	0	0.003755	0	0
NBPF10	100132406	broad.mit.edu	37	1	144619403	144619403	+	Missense_Mutation	SNP	A	G	G	rs4067646		TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr1:144619403A>G	uc009wig.1	+	5	738	c.544A>G	c.(544-546)Aaa>Gaa	p.K182E	NBPF10_uc010oxo.1_Missense_Mutation_p.K184E|NBPF10_uc010oxn.1_Intron|NBPF10_uc021oth.1_Intron|NBPF10_uc021otj.1_Intron|NBPF10_uc021oto.1_Intron|NBPF10_uc021otr.1_Intron|NBPF10_uc021ots.1_Intron|NBPF10_uc021otv.1_Intron|NBPF10_uc001ekk.1_Intron|NBPF10_uc010oyd.1_Intron|NBPF10_uc010oye.2_Missense_Mutation_p.K115E|NBPF10_uc001eli.3_Non-coding_Transcript|NBPF10_uc009wii.1_Intron	NM_001037675	NP_001032764	A6NDV3	A6NDV3_HUMAN	Homo sapiens neuroblastoma breakpoint family, member 9 (NBPF9), mRNA.	184										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GAAAGTGCAGAAATCATCTGC	0.413000														346			8		0	0	0.000978	0	0
BAGE	574	broad.mit.edu	37	21	11058322	11058322	+	Splice_Site	SNP	C	T	T			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr21:11058322C>T	uc002yiu.1	-	3	317	c.117_splice	c.e3-1	p.L39_splice	BAGE_uc002yit.1_Splice_Site_p.L39_splice|BAGE_uc002yiv.1_Splice_Site|BAGE_uc002yiw.1_Non-coding_Transcript	NM_182484	NP_872290	Q13072	BAGE1_HUMAN	Homo sapiens B melanoma antigen family, member 5 (BAGE5), mRNA.	39						extracellular region								Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AAATGCACATCGCTGAAAGGG	0.383000														157			14		0	0	0.003163	0	0
FGR	2268	broad.mit.edu	37	1	27939461	27939461	+	Silent	SNP	G	A	A			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr1:27939461G>A	uc001boj.3	-	10	1700	c.1554C>T	c.(1552-1554)tcC>tcT	p.S518S	FGR_uc001boi.3_Silent_p.S221S|FGR_uc001bok.3_Silent_p.S518S|FGR_uc001bol.3_Silent_p.S518S|FGR_uc001bom.3_Silent_p.S518S	NM_005248	NP_005239	P09769	FGR_HUMAN	Homo sapiens Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog (FGR), transcript variant 1, mRNA.	518					platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GTGGTTCAGCGGAGGTGAAGT	0.612000														35			21		0	0	0.001882	0	0
DDX60	55601	broad.mit.edu	37	4	169176878	169176878	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr4:169176878C>T	uc003irp.3	-	25	3833	c.3541G>A	c.(3541-3543)Gag>Aag	p.E1181K		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 (DDX60), mRNA.	1181							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		TTTTGTTTCTCTATGGATTTT	0.348000														49			11		0	0	0.001368	0	0
FLT3	2322	broad.mit.edu	37	13	28601295	28601295	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr13:28601295T>C	uc001urw.3	-	16	2219	c.2137A>G	c.(2137-2139)Act>Gct	p.T713A	FLT3_uc010aao.3_Non-coding_Transcript|FLT3_uc010tdn.2_Missense_Mutation_p.T713A	NM_004119	NP_004110	P36888	FLT3_HUMAN	Homo sapiens fms-related tyrosine kinase 3 (FLT3), mRNA.	713	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	TCTGTCCAAGTCCTGTGAAAT	0.358000			"""Mis, O"""		"""AML, ALL"""									109			20		0	0	0.001523	0	0
UGT1A1	54658	broad.mit.edu	37	2	234526363	234526363	+	Missense_Mutation	SNP	A	G	G	rs150485330		TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr2:234526363A>G	uc002vup.3	+	0	73	c.10A>G	c.(10-12)Aca>Gca	p.T4A	UGT1A1_uc010zmv.1_Missense_Mutation_p.T4A	NM_019076	NP_061949	P22309	UD11_HUMAN	Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A8 (UGT1A8), mRNA.	0					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding	p.T4A(3)		breast(1)|central_nervous_system(2)|endometrium(7)|large_intestine(5)|lung(9)|skin(4)|urinary_tract(2)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	CATGGCTCGCACAGGGTGGAC	0.562000														51			4		0	0	0.000248	0	0
TLK2	11011	broad.mit.edu	37	17	60600509	60600509	+	Silent	SNP	A	C	C			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr17:60600509A>C	uc010ddp.3	+	4	506	c.238A>C	c.(238-240)Agg>Cgg	p.R80R	TLK2_uc002izx.4_5'UTR|TLK2_uc002izz.4_Silent_p.R80R|TLK2_uc002jaa.4_Silent_p.R80R|TLK2_uc010wpd.2_Silent_p.R80R	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	Homo sapiens tousled-like kinase 2 (TLK2), transcript variant A, mRNA.	80					cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity	p.G80V(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(4)|large_intestine(6)|liver(2)|lung(10)|prostate(1)|stomach(1)|urinary_tract(1)	39						AGGCACTCCTAGGGGACATAA	0.269000														13			4		0	0	0.004482	0	0
CD300E	342510	broad.mit.edu	37	17	72613315	72613315	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr17:72613315C>G	uc002jlb.2	-	1	467	c.330G>C	c.(328-330)tgG>tgC	p.W110C		NM_181449	NP_852114	Q496F6	CLM2_HUMAN	Homo sapiens CD300e molecule (CD300E), mRNA.	110	Ig-like V-type.					integral to membrane|plasma membrane	receptor activity	p.V109M(1)		breast(1)|kidney(3)|large_intestine(4)|lung(4)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	19						AATCCAGGACCCACACTGTCT	0.547000														106			25		0	0	0.001061	0	0
HSPBP1	23640	broad.mit.edu	37	19	55785939	55785939	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr19:55785939G>A	uc002qkd.3	-	4	801	c.467C>T	c.(466-468)gCg>gTg	p.A156V	HSPBP1_uc002qjx.3_Missense_Mutation_p.A202V|HSPBP1_uc002qkc.3_Missense_Mutation_p.A156V	NM_001130106	NP_036399	Q9NZL4	HPBP1_HUMAN	Homo sapiens HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 (HSPBP1), transcript variant 2, mRNA.	159					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding		enzyme inhibitor activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)|urinary_tract(1)	8			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		CGCAGCCCCCGCCTCCAGGTA	0.672000														19			13		0	0	0.003163	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T	rs121913377		TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr7:140453136A>T	uc003vwc.4	-	14	1860	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(41204)|p.V600K(615)|p.V600?(377)|p.V600R(99)|p.V600D(40)|p.V600_K601>E(30)|p.V600L(28)|p.V600A(24)|p.V600G(22)|p.V600M(22)|p.A598_T599insV(7)|p.T599_V600insT(7)|p.T599I(5)|p.V600Q(4)|p.T599_R603>I(4)|p.T599_V600insTT(3)|p.T599_V600insDFGLAT(2)|p.T599_V600>IAL(2)|p.V600_S605>EK(2)|p.T599T(2)|p.V600_S605>DV(2)|p.V600_S605>D(2)|p.V600_W604del(1)|p.V600V(1)|p.T599_V600insV(1)|p.V600>DLAT(1)|p.D594_T599del(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome					65			27		0	0	0.001061	0	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr15:102515299G>A	uc002cdi.3	+	8	1943	c.523G>A	c.(523-525)Ggc>Agc	p.G175S	WASH3P_uc010bpo.3_Non-coding_Transcript|WASH3P_uc002cdq.3_Non-coding_Transcript|WASH3P_uc002cdr.3_Non-coding_Transcript					Homo sapiens WAS protein family homolog 3 pseudogene (WASH3P), non-coding RNA.									p.G374S(10)		central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						TGGGGGCATCGGCAAGGCCAA	0.652000														11			7		0	0	0.004482	0	0
TMEM74	157753	broad.mit.edu	37	8	109796547	109796547	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr8:109796547G>A	uc003ymy.1	-	1	886	c.781C>T	c.(781-783)Cgt>Tgt	p.R261C	TMEM74_uc003ymx.3_Intron|TMEM74_uc022azr.1_Missense_Mutation_p.R261C	NM_153015	NP_694560	Q96NL1	TMM74_HUMAN	Homo sapiens transmembrane protein 74 (TMEM74), mRNA.	261					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(57;3.08e-10)			CTGTTTCGACGATAGAGCTCC	0.512000														51			17		0	0	0.004990	0	0
CA2	760	broad.mit.edu	37	8	86386612	86386612	+	Silent	SNP	T	C	C			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr8:86386612T>C	uc003ydk.2	+	3	591	c.411T>C	c.(409-411)ccT>ccC	p.P137P		NM_000067	NP_000058	P00918	CAH2_HUMAN	Homo sapiens carbonic anhydrase II (CA2), mRNA.	137					one-carbon metabolic process	apical part of cell	carbonate dehydratase activity|zinc ion binding			central_nervous_system(2)|cervix(1)|large_intestine(2)|lung(5)|prostate(1)	11					Acetazolamide(DB00819)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dorzolamide(DB00869)|Ethinamate(DB01031)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	TGCAGCAACCTGATGGACTGG	0.398000														252			7		0	0	0.000443	0	0
FMN2	56776	broad.mit.edu	37	1	240255569	240255571	+	In_Frame_Del	DEL	GGC	-	-	rs71929261		TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr1:240255569_240255571delGGC	uc010pye.2	+	0	385_387	c.160_162delGGC	c.(160-162)ggcdel	p.G59del	FMN2_uc010pyd.2_In_Frame_Del_p.G59del	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	Homo sapiens formin 2 (FMN2), mRNA.	59					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding	p.G197delG(1)		NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GGGGGGAgggggcggcggcggcg	0.665													---	16	---	---	11	---					
THNSL2	55258	broad.mit.edu	37	2	88474921	88474922	+	Splice_Site	DEL	GT	-	-			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr2:88474921_88474922delGT	uc002ssy.4	+	3	2262	c.571_splice	c.e3+1	p.V191_splice	THNSL2_uc002ssw.4_Splice_Site_p.V191_splice|THNSL2_uc002sta.4_Splice_Site_p.V33_splice|THNSL2_uc010fhe.3_Splice_Site_p.V33_splice|THNSL2_uc021vkq.1_Frame_Shift_Del_p.G191fs|THNSL2_uc021vkr.1_Splice_Site_p.V191_splice	NM_018271	NP_060741	Q86YJ6	THNS2_HUMAN	Homo sapiens threonine synthase-like 2 (S. cerevisiae) (THNSL2), transcript variant 1, mRNA.	191					threonine biosynthetic process		threonine synthase activity	p.?(1)		breast(4)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	27						GTGTTTGGAGGTGTGTGCTGAG	0.505													---	42	---	---	16	---					
PRRC2A	7916	broad.mit.edu	37	6	31597456	31597457	+	Frame_Shift_Ins	INS	-	C	C			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr6:31597456_31597457insC	uc003nvb.4	+	13	2337_2338	c.2088_2089insC	c.(2086-2091)ccacccfs	p.P696fs	PRRC2A_uc011dnv.1_Intron|PRRC2A_uc003nvc.4_Frame_Shift_Ins_p.P696fs	NM_080686	NP_542417	P48634	PRC2A_HUMAN	Homo sapiens proline-rich coiled-coil 2A (PRRC2A), transcript variant 1, mRNA.	696	4 X 57 AA type A repeats.|Poly-Pro.					cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						CACAGGCTCCACCCCCGCCCCC	0.649													---	60	---	---	8	---					
PRDM12	59335	broad.mit.edu	37	9	133543701	133543702	+	Splice_Site	DEL	GT	-	-			TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr9:133543701_133543702delGT	uc004bzt.1	+	3	630	c.570_splice	c.e3+1	p.E190_splice		NM_021619	NP_067632	Q9H4Q4	PRD12_HUMAN	Homo sapiens PR domain containing 12 (PRDM12), mRNA.	190	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(2)|large_intestine(3)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11		all_hematologic(13;0.0433)|Acute lymphoblastic leukemia(5;0.0534)		OV - Ovarian serous cystadenocarcinoma(145;0.000344)		GGCCATTGAGGTGTGTGTGTGT	0.594													---	80	---	---	9	---					
MESP2	145873	broad.mit.edu	37	15	90320121	90320144	+	In_Frame_Del	DEL	AGGGGCAGGGGCAAGGGCAGGGGC	-	-	rs56192595		TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr15:90320121_90320144delAGGGGCAGGGGCAAGGGCAGGGGC	uc002bon.3	+	0	533_556	c.533_556delAGGGGCAGGGGCAAGGGCAGGGGC	c.(532-558)gaggggcaggggcaagggcaggggcag>gag	p.GQGQGQGQ195del	MESP2_uc010uqa.2_Intron	NM_001039958	NP_001035047	Q0VG99	MESP2_HUMAN	Homo sapiens mesoderm posterior 2 homolog (mouse) (MESP2), mRNA.	195	13 X 2 AA tandem repeats of G-Q.				Notch signaling pathway	nucleus	DNA binding	p.Q198_G205delQGQGQGQG(2)		kidney(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			ACGCaggcggaggggcaggggcaagggcaggggcaggggcaggg	0.777													---	9	---	---	5	---					
KRTAP10-6	386674	broad.mit.edu	37	21	46012219	46012220	+	In_Frame_Ins	INS	-	GGGGCGCAGCAGCTG	GGGGCGCAGCAGCTG	rs71199613		TCGA-FS-A1ZH-06A-11D-A197-08	TCGA-FS-A1ZH-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0120a766-01a8-46e2-bd76-7f7a2486cfaa	637507dc-91c1-4850-b3a0-35a1fb1134cd	g.chr21:46012219_46012220insGGGGCGCAGCAGCTG	uc002zfm.3	-	0	167_168	c.146_147insCAGCTGCTGCGCCCC	c.(145-147)ccg>ccCAGCTGCTGCGCCCCg	p.49_49P>PSCCAP	TSPEAR_uc002zfe.1_Intron|TSPEAR_uc010gpv.1_Intron	NM_198688	NP_941961	P60371	KR106_HUMAN	Homo sapiens keratin associated protein 10-6 (KRTAP10-6), mRNA.	49	29 X 5 AA repeats of C-C-X(3).					keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(6)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	23						GGCAGGGGGCCGGGGCGCAGCA	0.688													---	40	---	---	8	---