Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_Position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_File	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	chromosome_name	start	stop	reference	variant	type	gene_name	transcript_name	transcript_species	transcript_source	transcript_version	strand	transcript_status	trv_type	c_position	amino_acid_change	ucsc_cons	domain	all_domains	deletion_substructures	transcript_error	default_gene_name	gene_name_source	 ensembl_gene_id	tier	dbSNP	GMAF	n_ref_count	n_alt_count	normal_vaf	t_ref_count	t_alt_count	tumor_vaf	n_ref_count_val	n_alt_count_val	normal_vaf_val	t_ref_count_val	t_alt_count_val	tumor_vaf_val
PON3	0	genome.wustl.edu	37	7	94992147	94992147	+	Silent	SNP	G	G	A			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	7	94992147	94992147	G	A	SNP	PON3	ENST00000265627	human	ensembl	74_37	-1	known	silent	c.702	p.V234	1.000	pfam_Arylesterase,pfam_SGL,pfam_Strictosidine_synth_cons-reg,prints_Arylesterase	pfam_Arylesterase,pfam_SGL,pfam_Strictosidine_synth_cons-reg,prints_Arylesterase,prints_Paraoxonase2	-	no_errors	PON3	HGNC	ENSG00000105852	tier1	-	-	56	0	0.00	52	9	14.75	55	0	0.00	49	19	27.94
DCHS2	0	genome.wustl.edu	37	4	155243560	155243560	+	Missense_Mutation	SNP	G	G	A			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	4	155243560	155243560	G	A	SNP	DCHS2	ENST00000357232	human	ensembl	74_37	-1	known	missense	c.2734	p.P912S	0.780	pfam_Cadherin,superfamily_Cadherin-like,smart_Cadherin,pfscan_Cadherin	pfam_Cadherin,pfam_HTH_CenpB_D-bd_dom,superfamily_Cadherin-like,superfamily_Homeodomain-like,smart_Cadherin,pfscan_Cadherin,prints_Cadherin	-	no_errors	DCHS2	HGNC	ENSG00000197410	tier1	-	-	71	0	0.00	38	24	38.71	68	0	0.00	40	21	34.43
USP24	0	genome.wustl.edu	37	1	55567345	55567345	+	Missense_Mutation	SNP	G	G	A			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	1	55567345	55567345	G	A	SNP	USP24	ENST00000407756	human	ensembl	74_37	-1	known	missense	c.4577	p.S1526L	1.000	superfamily_ARM-type_fold	pfam_Peptidase_C19/C67,superfamily_UBA-like,superfamily_ARM-type_fold,pfscan_UBA/transl_elong_EF1B_N_euk,pfscan_Peptidase_C19/C67	-	no_errors	USP24	HGNC	ENSG00000162402	tier1	-	-	72	0	0.00	35	30	46.15	100	0	0.00	59	27	30.68
C9orf62	0	genome.wustl.edu	37	9	138235268	138235268	+	Silent	SNP	C	C	T			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	9	138235268	138235268	C	T	SNP	C9orf62	ENST00000320778	human	ensembl	74_37	+1	putative	silent	c.24	p.T8	0.000	NULL	NULL	-	no_errors	C9orf62	HGNC	ENSG00000178243	tier1	-	-	19	0	0.00	5	4	44.44	43	0	0.00	12	13	52.00
C12orf42	0	genome.wustl.edu	37	12	103699894	103699894	+	Missense_Mutation	SNP	G	G	C			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	12	103699894	103699894	G	C	SNP	C12orf42	ENST00000378113	human	ensembl	74_37	-1	known	missense	c.489	p.N163K	0.051	NULL	NULL	-	no_errors	C12orf42	HGNC	ENSG00000179088	tier1	-	-	91	0	0.00	63	12	16.00	133	0	0.00	75	15	16.67
ENSG00000233002	0	genome.wustl.edu	37	17	15638587	15638587	+	R	SNP	G	G	A			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	17	15638587	15638587	G	A	SNP	ENSG00000233002	ENST00000434017	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.007	-	-	-	no_errors	AC005324.6	Clone_based_vega_gene	ENSG00000233002	tier1	-	-	23	0	0.00	31	8	20.51	83	0	0.00	70	12	14.63
ACLY	0	genome.wustl.edu	37	17	40048663	40048663	+	Missense_Mutation	SNP	C	C	T			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	17	40048663	40048663	C	T	SNP	ACLY	ENST00000352035	human	ensembl	74_37	-1	known	missense	c.1639	p.E547K	1.000	pfam_CoA-bd,smart_CoA-bd,pirsf_ATP-citrate_synthase	pfam_Citrate_synthase-like,pfam_CoA_ligase,pfam_CoA-bd,pfam_ATP-grasp_succ-CoA_synth-type,superfamily_Citrate_synthase-like_core,superfamily_Succinyl-CoA_synth-like,smart_CoA-bd,pirsf_ATP-citrate_synthase	-	no_errors	ACLY	HGNC	ENSG00000131473	tier1	-	-	33	0	0.00	19	20	51.28	62	0	0.00	24	25	51.02
ZNF831	0	genome.wustl.edu	37	20	57829203	57829203	+	Missense_Mutation	SNP	C	C	A			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	20	57829203	57829203	C	A	SNP	ZNF831	ENST00000371030	human	ensembl	74_37	+1	novel	missense	c.4439	p.T1480N	0.000	NULL	smart_Znf_C2H2-like,pfscan_Znf_C2H2	-	no_errors	ZNF831	HGNC	ENSG00000124203	tier1	-	-	28	0	0.00	15	7	31.82	107	0	0.00	45	19	29.69
CNTRL	0	genome.wustl.edu	37	9	123924170	123924170	+	Missense_Mutation	SNP	A	A	G			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	9	123924170	123924170	A	G	SNP	CNTRL	ENST00000238341	human	ensembl	74_37	+1	known	missense	c.5126	p.N1709S	0.995	NULL	pfam_Leu-rich_rpt,superfamily_Prefoldin,superfamily_tR-bd_arm,smart_Leu-rich_rpt_typical-subtyp	-	no_errors	CNTRL	HGNC	ENSG00000119397	tier1	-	-	66	0	0.00	59	20	25.32	85	0	0.00	52	35	40.23
OR7G1	0	genome.wustl.edu	37	19	9225933	9225933	+	Nonsense_Mutation	SNP	G	G	T			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	19	9225933	9225933	G	T	SNP	OR7G1	ENST00000293614	human	ensembl	74_37	-1	known	nonsense	c.507	p.C169*	0.000	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR7G1	HGNC	ENSG00000161807	tier1	-	-	46	0	0.00	23	17	42.50	133	0	0.00	60	31	34.07
LRP2	0	genome.wustl.edu	37	2	170148813	170148813	+	Missense_Mutation	SNP	A	A	T			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	2	170148813	170148813	A	T	SNP	LRP2	ENST00000263816	human	ensembl	74_37	-1	known	missense	c.719	p.V240D	1.000	pfam_LDrepeatLR_classA_rpt,superfamily_LDrepeatLR_classA_rpt,smart_LDrepeatLR_classA_rpt,pfscan_LDrepeatLR_classA_rpt	pfam_LDrepeatLR_classA_rpt,pfam_LDLR_classB_rpt,superfamily_Growth_fac_rcpt_N_dom,superfamily_LDrepeatLR_classA_rpt,superfamily_TIL_dom,smart_LDrepeatLR_classA_rpt,smart_EG-like_dom,smart_EGF-like_Ca-bd_dom,smart_LDLR_classB_rpt,pfscan_EG-like_dom,pfscan_LDrepeatLR_classA_rpt,pfscan_LDLR_classB_rpt,prints_LDrepeatLR_classA_rpt	-	no_errors	LRP2	HGNC	ENSG00000081479	tier1	-	-	40	0	0.00	10	22	68.75	111	0	0.00	19	33	63.46
ZRANB3	0	genome.wustl.edu	37	2	136029367	136029367	+	Missense_Mutation	SNP	C	C	G			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	2	136029367	136029367	C	G	SNP	ZRANB3	ENST00000264159	human	ensembl	74_37	-1	known	missense	c.1177	p.A393P	1.000	pfam_Helicase_C,superfamily_P-loop_NTPase,smart_Helicase_C,pfscan_Helicase_C	pfam_SNF2_N,pfam_Helicase_C,pfam_HNH,pfam_Znf_RanBP2,pfam_Helicase/UvrB_dom,pfam_D/R_helicase_DEAD/DEAH_N,superfamily_P-loop_NTPase,smart_Helicase_ATP-bd,smart_Helicase_C,smart_Znf_RanBP2,smart_HNH_nuc,pfscan_Znf_RanBP2,pfscan_Helicase_ATP-bd,pfscan_Helicase_C	-	no_errors	ZRANB3	HGNC	ENSG00000121988	tier1	-	-	57	0	0.00	18	30	62.50	63	0	0.00	13	14	51.85
ZMYM1	0	genome.wustl.edu	37	1	35580503	35580503	+	Silent	SNP	C	C	T			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	1	35580503	35580503	C	T	SNP	ZMYM1	ENST00000359858	human	ensembl	74_37	+1	novel	silent	c.3072	p.I1024	1.000	superfamily_RNaseH-like_dom	pfam_Znf_MYM,pfam_HATC_dom_C,superfamily_RNaseH-like_dom,smart_TRASH_dom	-	no_errors	ZMYM1	HGNC	ENSG00000197056	tier1	-	-	78	0	0.00	63	36	36.36	78	0	0.00	54	31	36.47
NLRP12	0	genome.wustl.edu	37	19	54327234	54327234	+	Silent	SNP	C	C	A			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	19	54327234	54327234	C	A	SNP	NLRP12	ENST00000324134	human	ensembl	74_37	-1	known	silent	c.195	p.G65	0.034	pfam_DAPIN,superfamily_DEATH-like_dom,pfscan_DAPIN	pfam_DAPIN,superfamily_DEATH-like_dom,superfamily_P-loop_NTPase,smart_Leu-rich_rpt_RNase_inh_sub-typ,pfscan_CHT_NTPase,pfscan_DAPIN	-	no_errors	NLRP12	HGNC	ENSG00000142405	tier1	-	-	71	0	0.00	39	7	15.22	69	0	0.00	31	12	27.91
HUNK	0	genome.wustl.edu	37	21	33318455	33318455	+	Missense_Mutation	SNP	T	T	C			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	21	33318455	33318455	T	C	SNP	HUNK	ENST00000270112	human	ensembl	74_37	+1	known	missense	c.718	p.Y240H	1.000	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_LipoPS_kinase,pfam_RIO-like_kinase,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	-	no_errors	HUNK	HGNC	ENSG00000142149	tier1	-	-	61	0	0.00	59	24	28.57	84	0	0.00	52	19	26.76
PRAMENP	0	genome.wustl.edu	37	22	22348852	22348852	+	R	SNP	G	G	T			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	22	22348852	22348852	G	T	SNP	PRAMENP	ENST00000337471	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.002	-	-	-	no_errors	PRAMENP	HGNC	ENSG00000197549	tier1	-	-	21	0	0.00	17	7	29.17	129	0	0.00	62	29	31.87
USH2A	0	genome.wustl.edu	37	1	216251697	216251697	+	Missense_Mutation	SNP	A	A	C			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	A	A	A	C	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	1	216251697	216251697	A	C	SNP	USH2A	ENST00000366943	human	ensembl	74_37	-1	known	missense	c.5306	p.L1769R	1.000	pfam_Laminin_G,superfamily_ConA-like_lec_gl_sf,superfamily_Fibronectin_type3,smart_Laminin_G,pfscan_Laminin_G	pfam_Fibronectin_type3,pfam_EGF_laminin,pfam_Laminin_G,superfamily_ConA-like_lec_gl_sf,superfamily_Fibronectin_type3,smart_LamG-like,smart_Laminin_N,smart_EGF_laminin,smart_Fibronectin_type3,smart_Laminin_G,pfscan_EGF_laminin,pfscan_Fibronectin_type3,pfscan_Laminin_G,pfscan_Laminin_N	-	no_errors	USH2A	HGNC	ENSG00000042781	tier1	-	-	57	0	0.00	8	17	68.00	92	0	0.00	25	31	55.36
SPACA3	0	genome.wustl.edu	37	17	31324480	31324480	+	Missense_Mutation	SNP	C	C	G			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	17	31324480	31324480	C	G	SNP	SPACA3	ENST00000269053	human	ensembl	74_37	+1	known	missense	c.520	p.L174V	0.544	pfam_Glyco_hydro_22,superfamily_Lysozyme-like_dom,smart_Glyco_hydro_22,prints_Glyco_hydro_22,prints_Glyco_hydro_22_lys	pfam_Glyco_hydro_22,superfamily_Lysozyme-like_dom,smart_Glyco_hydro_22,prints_Glyco_hydro_22,prints_Glyco_hydro_22_lys	-	no_errors	SPACA3	HGNC	ENSG00000141316	tier1	-	-	25	0	0.00	12	10	45.45	72	0	0.00	46	23	33.33
TPR	0	genome.wustl.edu	37	1	186302508	186302508	+	Missense_Mutation	SNP	G	G	A			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	1	186302508	186302508	G	A	SNP	TPR	ENST00000367478	human	ensembl	74_37	-1	known	missense	c.5201	p.P1734L	1.000	NULL	pfam_TPR_MLP1_2,superfamily_Prefoldin,superfamily_tR-bd_arm	-	no_errors	TPR	HGNC	ENSG00000047410	tier1	-	-	76	0	0.00	7	40	85.11	111	0	0.00	28	21	42.86
ATRX	0	genome.wustl.edu	37	X	76888728	76888728	+	Nonsense_Mutation	SNP	T	T	A			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	X	76888728	76888728	T	A	SNP	ATRX	ENST00000373344	human	ensembl	74_37	-1	known	nonsense	c.5101	p.K1701*	1.000	pfam_SNF2_N,superfamily_P-loop_NTPase,smart_Helicase_ATP-bd,pfscan_Helicase_ATP-bd	pfam_SNF2_N,pfam_Helicase_C,superfamily_P-loop_NTPase,superfamily_Znf_FYVE_PHD,smart_Helicase_ATP-bd,smart_Helicase_C,pfscan_Helicase_ATP-bd,pfscan_Helicase_C	-	no_errors	ATRX	HGNC	ENSG00000085224	tier1	-	-	51	0	0.00	40	30	42.86	65	0	0.00	30	24	44.44
ENSG00000244306	0	genome.wustl.edu	37	14	19891124	19891124	+	R	SNP	T	T	A			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	14	19891124	19891124	T	A	SNP	ENSG00000244306	ENST00000547285	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.023	-	-	-	no_errors	CTD-2314B22.3	Clone_based_vega_gene	ENSG00000244306	tier1	-	-	31	0	0.00	31	13	29.55	80	0	0.00	54	20	27.03
KEL	0	genome.wustl.edu	37	7	142638486	142638486	+	Missense_Mutation	SNP	C	C	G			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	7	142638486	142638486	C	G	SNP	KEL	ENST00000355265	human	ensembl	74_37	-1	known	missense	c.2052	p.K684N	0.000	pfam_Peptidase_M13_C	pfam_Peptidase_M13_N,pfam_Peptidase_M13_C,prints_Peptidase_M13_C	-	no_errors	KEL	HGNC	ENSG00000197993	tier1	-	-	47	0	0.00	21	13	38.24	34	0	0.00	14	10	41.67
SLC20A1	0	genome.wustl.edu	37	2	113414763	113414763	+	Silent	SNP	C	C	T			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	2	113414763	113414763	C	T	SNP	SLC20A1	ENST00000272542	human	ensembl	74_37	+1	known	silent	c.723	p.F241	1.000	pfam_Phos_transporter	pfam_Phos_transporter	-	no_errors	SLC20A1	HGNC	ENSG00000144136	tier1	-	-	23	0	0.00	23	20	46.51	58	0	0.00	11	25	69.44
CHST10	0	genome.wustl.edu	37	2	101014550	101014550	+	Nonsense_Mutation	SNP	C	C	A			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	2	101014550	101014550	C	A	SNP	CHST10	ENST00000542617	human	ensembl	74_37	-1	known	nonsense	c.391	p.E131*	1.000	NULL	pfam_Sulfotransferase,superfamily_P-loop_NTPase	-	no_errors	CHST10	HGNC	ENSG00000115526	tier1	-	-	33	0	0.00	21	7	25.00	80	0	0.00	26	11	29.73
FSCB	0	genome.wustl.edu	37	14	44976143	44976143	+	Missense_Mutation	SNP	G	G	C			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	14	44976143	44976143	G	C	SNP	FSCB	ENST00000340446	human	ensembl	74_37	-1	known	missense	c.48	p.H16Q	0.000	NULL	NULL	-	no_errors	FSCB	HGNC	ENSG00000189139	tier1	-	-	76	0	0.00	58	18	23.68	96	0	0.00	62	13	17.33
FOLH1B	0	genome.wustl.edu	37	11	89385760	89385760	+	R	SNP	C	C	A			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	11	89385760	89385760	C	A	SNP	FOLH1B	ENST00000526379	human	ensembl	74_37	+1	known	rna	NULL	NULL	1.000	-	-	-	no_errors	FOLH1B	HGNC	ENSG00000134612	tier1	-	-	107	0	0.00	29	46	61.33	73	0	0.00	18	28	60.87
GVINP1	0	genome.wustl.edu	37	11	6735924	6735924	+	R	SNP	T	T	A			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	11	6735924	6735924	T	A	SNP	GVINP1	ENST00000526769	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.878	-	-	-	no_errors	GVINP1	HGNC	ENSG00000254838	tier1	-	-	75	0	0.00	21	31	59.62	60	0	0.00	17	13	43.33
ANO2	0	genome.wustl.edu	37	12	5908718	5908718	+	Missense_Mutation	SNP	G	G	A			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	12	5908718	5908718	G	A	SNP	ANO2	ENST00000356134	human	ensembl	74_37	-1	known	missense	c.1001	p.A334V	1.000	NULL	pfam_Anoctamin	-	no_errors	ANO2	HGNC	ENSG00000047617	tier1	-	-	94	0	0.00	52	13	20.00	90	0	0.00	50	13	20.63
ITPK1-AS1	0	genome.wustl.edu	37	14	93537319	93537319	+	R	SNP	G	G	T			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	14	93537319	93537319	G	T	SNP	ITPK1-AS1	ENST00000553639	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.107	-	-	-	no_errors	ITPK1-AS1	HGNC	ENSG00000258730	tier1	-	-	46	0	0.00	25	15	37.50	81	0	0.00	34	27	44.26
SASH1	0	genome.wustl.edu	37	6	148852780	148852780	+	Missense_Mutation	SNP	G	G	A			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	6	148852780	148852780	G	A	SNP	SASH1	ENST00000367467	human	ensembl	74_37	+1	known	missense	c.1547	p.S516N	1.000	pfam_rSAM/SH3_domain-containing	pfam_rSAM/SH3_domain-containing,pfam_SAM_2,pfam_SAM_type1,pfam_SH3_2,superfamily_SAM/pointed,superfamily_SH3_domain,smart_SH3_domain,smart_SAM,pfscan_SAM	-	no_errors	SASH1	HGNC	ENSG00000111961	tier1	-	-	70	0	0.00	18	30	62.50	89	0	0.00	12	14	53.85
GFRA3	0	genome.wustl.edu	37	5	137593567	137593567	+	Silent	SNP	G	G	A			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	5	137593567	137593567	G	A	SNP	GFRA3	ENST00000274721	human	ensembl	74_37	-1	known	silent	c.546	p.Y182	0.602	pfam_GDNF/GAS1,smart_GDNF/GAS1	pfam_GDNF/GAS1,smart_GDNF/GAS1,prints_GDNF_rcpt,prints_GDNF_rcpt_A3	-	no_errors	GFRA3	HGNC	ENSG00000146013	tier1	-	-	20	0	0.00	6	10	62.50	23	0	0.00	11	10	47.62
SHROOM4	0	genome.wustl.edu	37	X	50350911	50350911	+	Silent	SNP	C	C	T			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	X	50350911	50350911	C	T	SNP	SHROOM4	ENST00000289292	human	ensembl	74_37	-1	known	silent	c.3231	p.R1077	0.008	NULL	pfam_ASD2,pfam_PDZ,superfamily_PDZ,smart_PDZ,pfscan_PDZ	-	no_errors	SHROOM4	HGNC	ENSG00000158352	tier1	-	-	48	0	0.00	65	11	14.47	96	0	0.00	59	15	20.27
FAT1	0	genome.wustl.edu	37	4	187629482	187629482	+	Silent	SNP	G	G	A			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	4	187629482	187629482	G	A	SNP	FAT1	ENST00000441802	human	ensembl	74_37	-1	known	silent	c.1500	p.Y500	1.000	pfam_Cadherin,superfamily_Cadherin-like,smart_Cadherin,pfscan_Cadherin	pfam_Cadherin,pfam_Laminin_G,pfam_EG-like_dom,pfam_EGF-like_Ca-bd_dom,superfamily_ConA-like_lec_gl_sf,superfamily_Cadherin-like,smart_Cadherin,smart_EG-like_dom,smart_Laminin_G,smart_EGF-like_Ca-bd_dom,prints_Cadherin,pfscan_EG-like_dom,pfscan_Laminin_G,pfscan_Cadherin	-	no_errors	FAT1	HGNC	ENSG00000083857	tier1	-	-	41	0	0.00	31	21	40.38	133	0	0.00	48	40	45.45
MERTK	0	genome.wustl.edu	37	2	112722787	112722787	+	Silent	SNP	C	C	T			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	2	112722787	112722787	C	T	SNP	MERTK	ENST00000295408	human	ensembl	74_37	+1	known	silent	c.777	p.V259	0.449	smart_Ig_sub,pfscan_Ig-like_dom	pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Prot_kinase_dom,pfam_Fibronectin_type3,pfam_Ig_I-set,superfamily_Kinase-like_dom,superfamily_Fibronectin_type3,superfamily_Rhodanese-like_dom,smart_Ig_sub,smart_Fibronectin_type3,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Fibronectin_type3,pfscan_Prot_kinase_dom,pfscan_Ig-like_dom,prints_Ser-Thr/Tyr_kinase_cat_dom	-	no_errors	MERTK	HGNC	ENSG00000153208	tier1	-	-	44	0	0.00	36	16	30.77	81	0	0.00	32	21	39.62
UQCRC1	0	genome.wustl.edu	37	3	48641757	48641757	+	Missense_Mutation	SNP	T	T	C			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	3	48641757	48641757	T	C	SNP	UQCRC1	ENST00000203407	human	ensembl	74_37	-1	known	missense	c.535	p.M179V	0.001	pfam_Pept_M16_N,superfamily_Metalloenz_LuxS/M16	pfam_Pept_M16_N,pfam_Peptidase_M16_C,superfamily_Metalloenz_LuxS/M16	-	no_errors	UQCRC1	HGNC	ENSG00000010256	tier1	-	-	30	0	0.00	14	14	50.00	49	0	0.00	28	16	36.36
LOC388813	0	genome.wustl.edu	37	21	16015347	16015347	+	Silent	SNP	T	T	C			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	21	16015347	16015347	T	C	SNP	LOC388813	ENST00000400562	human	ensembl	74_37	-1	putative	silent	c.132	p.E44	0.003	NULL	NULL	-	no_errors	AF165138.7	Clone_based_vega_gene	ENSG00000243440	tier1	-	-	86	0	0.00	54	29	34.94	93	0	0.00	48	19	28.36
RB1	0	genome.wustl.edu	37	13	49027153	49027156	+	Frame_Shift_Del	DEL	AAAC	AAAC	-			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	AAAC	AAAC	AAAC	-	AAAC	AAAC	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	13	49027153	49027156	AAAC	-	DEL	RB1	ENST00000267163	human	ensembl	74_37	+1	known	frame_shift_del	c.1720_1723	p.K574fs	1.000:1.000:1.000:1.000	superfamily_Cyclin-like	pfam_RB_C,pfam_RB_A,pfam_RB_B,pfam_RB_N,superfamily_Cyclin-like,smart_Cyclin-like	-	no_errors	RB1	HGNC	ENSG00000139687	tier1			100	0	0.00	42	36	46.15	83	0	0.00	24	21	46.67
TP53	0	genome.wustl.edu	37	17	7574025	7574025	+	Frame_Shift_Del	DEL	C	C	-			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	C	C	C	-	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	17	7574025	7574025	C	-	DEL	TP53	ENST00000269305	human	ensembl	74_37	-1	known	frame_shift_del	c.1002	p.R335fs	0.879	pfam_p53_tetrameristn,superfamily_p53_tetrameristn,prints_p53_tumour_suppressor	pfam_p53_D-bd,pfam_p53_tetrameristn,pfam_p53_transactivation_domain,superfamily_p53-like_TF_D-bd,superfamily_p53_tetrameristn,prints_p53_tumour_suppressor	-	no_errors	TP53	HGNC	ENSG00000141510	tier1			30	0	0.00	7	10	58.82	88	0	0.00	10	14	58.33
ANP32AP1	0	genome.wustl.edu	37	15	35530195	35530195	+	R	SNP	G	G	A			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	15	35530195	35530195	G	A	SNP	ANP32AP1	ENST00000560832	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.056	-	-	-	no_errors	ANP32AP1	HGNC	ENSG00000259516	tier1	-	-	80	0	0.00	50	16	24.24	34	0	0.00	9	5	35.71
EMR3	0	genome.wustl.edu	37	19	14752409	14752409	+	Missense_Mutation	SNP	G	G	A			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	19	14752409	14752409	G	A	SNP	EMR3	ENST00000253673	human	ensembl	74_37	-1	known	missense	c.1070	p.T357I	0.000	pfam_GPCR_2_secretin-like,pfscan_GPCR_2-like	pfam_GPCR_2_secretin-like,pfam_GPS_dom,pfam_EGF-like_Ca-bd_dom,smart_EG-like_dom,smart_EGF-like_Ca-bd_dom,smart_GPS_dom,pfscan_EG-like_dom,pfscan_GPS_dom,pfscan_GPCR_2-like,prints_GPCR_2_EMR1_rcpt,prints_GPCR_2_secretin-like,prints_GPCR_2_CD97	-	no_errors	EMR3	HGNC	ENSG00000131355	tier1	-	-	39	0	0.00	13	22	62.86	41	0	0.00	9	14	60.87
GPR135	0	genome.wustl.edu	37	14	59931123	59931123	+	Silent	SNP	G	G	A			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	14	59931123	59931123	G	A	SNP	GPR135	ENST00000395116	human	ensembl	74_37	-1	known	silent	c.822	p.G274	0.958	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_GPCR_Rhodpsn	-	no_errors	GPR135	HGNC	ENSG00000181619	tier1	-	-	15	0	0.00	11	4	26.67	11	0	0.00	6	2	25.00
PTEN	0	genome.wustl.edu	37	10	89692905	89692905	+	Missense_Mutation	SNP	G	G	A			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	10	89692905	89692905	G	A	SNP	PTEN	ENST00000371953	human	ensembl	74_37	+1	known	missense	c.389	p.R130Q	1.000	pfam_Dual-sp_phosphatase_cat-dom,pfam_Tyr_Pase_rcpt/non-rcpt,smart_Tyr_Pase_cat,pirsf_Bifunc_PIno_P3_Pase/Pase_PTEN,pfscan_Tyr/Dual-sp_Pase,pfscan_Phosphatase_tensin-typ	pfam_Tensin_phosphatase_C2-dom,pfam_Dual-sp_phosphatase_cat-dom,pfam_Tyr_Pase_rcpt/non-rcpt,superfamily_C2_dom,smart_Tyr_Pase_cat,pirsf_Bifunc_PIno_P3_Pase/Pase_PTEN,pfscan_Tyr/Dual-sp_Pase,pfscan_Phosphatase_tensin-typ,pfscan_Tensin_phosphatase_C2-dom	-	no_errors	PTEN	HGNC	ENSG00000171862	tier1	rs121909229	-	122	0	0.00	34	66	66.00	34	0	0.00	6	12	66.67
RNF213	0	genome.wustl.edu	37	17	78282903	78282903	+	Missense_Mutation	SNP	A	A	G			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	17	78282903	78282903	A	G	SNP	RNF213	ENST00000582970	human	ensembl	74_37	+1	known	missense	c.2587	p.K863E	0.000	NULL	superfamily_P-loop_NTPase,smart_AAA+_ATPase,smart_Znf_RING,pfscan_Znf_RING	-	no_errors	RNF213	HGNC	ENSG00000173821	tier1	-	-	41	0	0.00	12	26	68.42	71	0	0.00	8	21	72.41
TRRAP	0	genome.wustl.edu	37	7	98602905	98602905	+	Silent	SNP	C	C	T			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	7	98602905	98602905	C	T	SNP	TRRAP	ENST00000359863	human	ensembl	74_37	+1	known	silent	c.10645	p.L3549	1.000	pfam_PI3/4_kinase_cat_dom,superfamily_Kinase-like_dom,smart_PI3/4_kinase_cat_dom,pfscan_PI3/4_kinase_cat_dom	pfam_PIK-rel_kinase_FAT,pfam_PI3/4_kinase_cat_dom,superfamily_Kinase-like_dom,superfamily_ARM-type_fold,smart_PI3/4_kinase_cat_dom,pfscan_PIK_FAT,pfscan_FATC,pfscan_PI3/4_kinase_cat_dom	-	no_errors	TRRAP	HGNC	ENSG00000196367	tier1	-	-	36	0	0.00	18	9	33.33	13	0	0.00	6	4	40.00
TTC7A	0	genome.wustl.edu	37	2	47300982	47300982	+	Missense_Mutation	SNP	G	G	C			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	2	47300982	47300982	G	C	SNP	TTC7A	ENST00000319190	human	ensembl	74_37	+1	known	missense	c.2497	p.V833L	0.003	pfam_TPR_1,smart_TPR_repeat,pfscan_TPR_repeat,pfscan_TPR-contain_dom	pfam_TPR_2,pfam_TPR_1,smart_TPR_repeat,pfscan_TPR_repeat,pfscan_TPR-contain_dom	-	no_errors	TTC7A	HGNC	ENSG00000068724	tier1	-	-	23	0	0.00	9	9	50.00	25	0	0.00	7	6	46.15
ANGEL2	0	genome.wustl.edu	37	1	213188755	213188755	+	R	DEL	T	T	-			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	1	213188755	213188755	T	-	DEL	ANGEL2	ENST00000481918	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	ANGEL2	HGNC	ENSG00000174606	tier1			25	0	0.00	8	6	42.86	11	0	0.00	4	1	20.00
HELZ2	0	genome.wustl.edu	37	20	62203295	62203295	+	R	SNP	G	G	A			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	20	62203295	62203295	G	A	SNP	HELZ2	ENST00000479540	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.747	-	-	-	no_errors	HELZ2	HGNC	ENSG00000130589	tier1	rs75418499	-	11	0	0.00	10	5	33.33	9	0	0.00	2	0	0.00
HKDC1	0	genome.wustl.edu	37	10	71025434	71025434	+	Silent	SNP	C	C	T			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	10	71025434	71025434	C	T	SNP	HKDC1	ENST00000354624	human	ensembl	74_37	+1	known	silent	c.2466	p.C822	0.996	pfam_Hexokinase_C,prints_Hexokinase	pfam_Hexokinase_C,pfam_Hexokinase_N,prints_Hexokinase	-	no_errors	HKDC1	HGNC	ENSG00000156510	tier1	-	-	63	0	0.00	42	4	8.70	27	0	0.00	8	0	0.00
MT-ND6	0	genome.wustl.edu	37	MT	14384	14384	+	Missense_Mutation	SNP	G	G	A			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	MT	14384	14384	G	A	SNP	MT-ND6	ENST00000361681	human	ensembl	74_37	-1	known	missense	c.290	p.A97V	NULL	pfam_DH_UbQ/plastoQ_OxRdtase_su6	pfam_DH_UbQ/plastoQ_OxRdtase_su6	-	no_errors	MT-ND6	HGNC	ENSG00000198695	tier1	-	-	254	0	0.00	38	8	17.39	5	0	0.00	0	0	0.00
SLC16A11	0	genome.wustl.edu	37	17	6946879	6946879	+	Missense_Mutation	SNP	C	C	A			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	17	6946879	6946879	C	A	SNP	SLC16A11	ENST00000308009	human	ensembl	74_37	-1	known	missense	c.26	p.R9M	0.009	NULL	pfam_MFS,superfamily_MFS_dom_general_subst_transpt,pfscan_MFS_dom	-	no_errors	SLC16A11	HGNC	ENSG00000174326	tier1	-	-	11	0	0.00	11	4	26.67	5	0	0.00	9	0	0.00
ACADVL	0	genome.wustl.edu	37	17	7123240	7123241	+	R	INS	-	-	GGGCGTGCAGGACGC			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	-	-					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	17	7123240	7123241	-	GGGCGTGCAGGACGC	INS	ACADVL	ENST00000577857	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.000:0.000	-	-	-	no_errors	ACADVL	HGNC	ENSG00000072778	tier1			2	0	0.00	0	0	0.00	2	0	0.00	0	0	0.00
ENSG00000221280	0	genome.wustl.edu	37	12	118604652	118604653	+	R	INS	-	-	ACAC			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	-	-					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	12	118604652	118604653	-	ACAC	INS	ENSG00000221280	ENST00000408353	human	ensembl	74_37	+1	novel	rna	NULL	NULL	0.002:0.000	-	-	-	no_errors	AC026366.1	Clone_based_ensembl_gene	ENSG00000221280	tier1			10	0	0.00	4	4	50.00	0	0	0.00	0	0	0.00
BCMO1	0	genome.wustl.edu	37	16	81323975	81323975	+	Silent	SNP	C	C	T			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	16	81323975	81323975	C	T	SNP	BCMO1	ENST00000258168	human	ensembl	74_37	+1	known	silent	c.1437	p.V479	0.992	pfam_Carotenoid_Oase	pfam_Carotenoid_Oase	-	no_errors	BCMO1	HGNC	ENSG00000135697	tier1	-	-	67	0	0.00	51	7	12.07	111	0	0.00	92	2	2.13
ZNF234	0	genome.wustl.edu	37	19	44661971	44661971	+	Missense_Mutation	SNP	G	G	T			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	19	44661971	44661971	G	T	SNP	ZNF234	ENST00000426739	human	ensembl	74_37	+1	known	missense	c.1802	p.C601F	1.000	pfam_Znf_C2H2,smart_Znf_C2H2-like,pfscan_Znf_C2H2	pfam_Znf_C2H2,pfam_Krueppel-associated_box,superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,smart_Znf_C2H2-like,pfscan_Znf_C2H2,pfscan_Krueppel-associated_box	-	no_errors	ZNF234	HGNC	ENSG00000263002	tier1	-	-	58	0	0.00	44	4	8.33	45	0	0.00	24	2	7.69
BCMO1	0	genome.wustl.edu	37	16	81323977	81323977	+	Missense_Mutation	SNP	C	C	T			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	16	81323977	81323977	C	T	SNP	BCMO1	ENST00000258168	human	ensembl	74_37	+1	known	missense	c.1439	p.S480F	0.997	pfam_Carotenoid_Oase	pfam_Carotenoid_Oase	-	no_errors	BCMO1	HGNC	ENSG00000135697	tier1	-	-	66	0	0.00	47	7	12.96	110	0	0.00	92	2	2.13
STAG3L5P-PVRIG2P-PILRB	0	genome.wustl.edu	37	7	99943552	99943553	+	R	INS	-	-	T			TCGA-WK-A8Y0-01A-11D-A417-09	TCGA-WK-A8Y0-10D-01D-A41A-09	-	-					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	efdaf8c2-1a45-4677-9eac-e5a8ab3dae46	f02bb3c1-15b5-43b8-a511-7e422b29cdbc	7	99943552	99943553	-	T	INS	STAG3L5P-PVRIG2P-PILRB	ENST00000310771	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.000:0.002	-	-	-	no_errors	STAG3L5P-PVRIG2P-PILRB	HGNC	ENSG00000272752	tier1			32	0	0.00	20	3	13.04	49	0	0.00	35	2	5.41