Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_Position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_File	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	chromosome_name	start	stop	reference	variant	type	gene_name	transcript_name	transcript_species	transcript_source	transcript_version	strand	transcript_status	trv_type	c_position	amino_acid_change	ucsc_cons	domain	all_domains	deletion_substructures	transcript_error	default_gene_name	gene_name_source	 ensembl_gene_id	tier	dbSNP	GMAF	n_ref_count	n_alt_count	normal_vaf	t_ref_count	t_alt_count	tumor_vaf	n_ref_count_val	n_alt_count_val	normal_vaf_val	t_ref_count_val	t_alt_count_val	tumor_vaf_val
MIR369	0	genome.wustl.edu	37	14	101531999	101531999	+	R	SNP	T	T	C			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	14	101531999	101531999	T	C	SNP	MIR369	ENST00000362155	human	ensembl	74_37	+1	known	rna	NULL	NULL	1.000	-	-	-	no_errors	MIR369	HGNC	ENSG00000199025	tier1	-	-	34	0	0.00	36	4	10.00	60	0	0.00	53	13	19.70
CSNK1D	0	genome.wustl.edu	37	17	80208020	80208020	+	R	SNP	G	G	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	17	80208020	80208020	G	A	SNP	CSNK1D	ENST00000578904	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	CSNK1D	HGNC	ENSG00000141551	tier1	-	-	63	0	0.00	34	11	24.44	51	0	0.00	45	12	21.05
RPH3A	0	genome.wustl.edu	37	12	113327846	113327846	+	Silent	SNP	C	C	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	12	113327846	113327846	C	A	SNP	RPH3A	ENST00000389385	human	ensembl	74_37	+1	known	silent	c.1581	p.T527	0.998	NULL	pfam_C2_dom,pfam_Znf_FYVE-typ,superfamily_C2_dom,superfamily_Znf_FYVE_PHD,smart_C2_dom,pfscan_C2_dom,pfscan_Znf_FYVE-typ,pfscan_Znf_FYVE-rel,prints_Synaptotagmin,prints_C2_dom	-	no_errors	RPH3A	HGNC	ENSG00000089169	tier1	-	-	40	0	0.00	47	25	34.72	36	0	0.00	34	25	42.37
PCDHA7	0	genome.wustl.edu	37	5	140215733	140215733	+	Missense_Mutation	SNP	C	C	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	5	140215733	140215733	C	A	SNP	PCDHA7	ENST00000525929	human	ensembl	74_37	+1	known	missense	c.1765	p.H589N	0.994	pfam_Cadherin,superfamily_Cadherin-like,pfscan_Cadherin	pfam_Cadherin,pfam_Cadherin_N,superfamily_Cadherin-like,smart_Cadherin,prints_Cadherin,pfscan_Cadherin	-	no_errors	PCDHA7	HGNC	ENSG00000204963	tier1	-	-	97	0	0.00	116	30	20.55	11	0	0.00	19	8	29.63
TOMM7	0	genome.wustl.edu	37	7	22852686	22852686	+	R	SNP	C	C	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	7	22852686	22852686	C	A	SNP	TOMM7	ENST00000463284	human	ensembl	74_37	-1	putative	rna	NULL	NULL	0.465	-	-	-	no_errors	TOMM7	HGNC	ENSG00000196683	tier1	-	-	25	0	0.00	38	5	11.63	65	0	0.00	64	11	14.67
RAB18	0	genome.wustl.edu	37	10	27821508	27821508	+	Missense_Mutation	SNP	G	G	C			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	10	27821508	27821508	G	C	SNP	RAB18	ENST00000356940	human	ensembl	74_37	+1	known	missense	c.259	p.V87L	1.000	pfam_Small_GTPase,pfam_MIRO-like,pfam_Small_GTPase_ARF/SAR,pfam_Gtr1_RagA,pfam_EF_GTP-bd_dom,superfamily_P-loop_NTPase,smart_Small_GTPase_ARF,smart_Small_GTPase_Ras,smart_Small_GTPase_Rab_type,smart_Small_GTPase_Rho,smart_Ran_GTPase,tigrfam_Small_GTP-bd_dom	pfam_Small_GTPase,pfam_MIRO-like,pfam_Small_GTPase_ARF/SAR,pfam_Gtr1_RagA,pfam_EF_GTP-bd_dom,superfamily_P-loop_NTPase,smart_Small_GTPase_ARF,smart_Small_GTPase_Ras,smart_Small_GTPase_Rab_type,smart_Small_GTPase_Rho,smart_Ran_GTPase,prints_Small_GTPase,tigrfam_Small_GTP-bd_dom	-	no_errors	RAB18	HGNC	ENSG00000099246	tier1	-	-	39	0	0.00	50	19	27.54	63	0	0.00	42	11	20.75
OR4D11	0	genome.wustl.edu	37	11	59271507	59271507	+	Missense_Mutation	SNP	T	T	G			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	T	T	T	G	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	11	59271507	59271507	T	G	SNP	OR4D11	ENST00000313253	human	ensembl	74_37	+1	known	missense	c.459	p.F153L	0.026	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR4D11	HGNC	ENSG00000176200	tier1	-	-	71	0	0.00	104	11	9.57	72	1	1.37	63	8	11.27
RBM3	0	genome.wustl.edu	37	X	48434970	48434970	+	Missense_Mutation	SNP	C	C	T			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	X	48434970	48434970	C	T	SNP	RBM3	ENST00000376755	human	ensembl	74_37	+1	known	missense	c.391	p.R131C	0.600	NULL	pfam_RRM_dom,smart_RRM_dom,pfscan_RRM_dom	-	no_errors	RBM3	HGNC	ENSG00000102317	tier1	-	-	25	0	0.00	40	10	20.00	106	0	0.00	103	16	13.45
NOTCH3	0	genome.wustl.edu	37	19	15276877	15276877	+	Silent	SNP	A	A	G			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	19	15276877	15276877	A	G	SNP	NOTCH3	ENST00000263388	human	ensembl	74_37	-1	known	silent	c.5388	p.A1796	0.976	pirsf_Notch,pfam_Ankyrin_rpt,superfamily_Ankyrin_rpt-contain_dom,smart_Ankyrin_rpt,pfscan_Ankyrin_rpt-contain_dom	pirsf_Notch,pfam_EG-like_dom,pfam_EGF-like_Ca-bd_dom,pfam_Ankyrin_rpt,pfam_Notch_dom,pfam_Notch_NODP_dom,pfam_Notch_NOD_dom,pfam_EGF_extracell,pfam_DUF3454_notch,superfamily_Ankyrin_rpt-contain_dom,superfamily_Notch_dom,smart_EG-like_dom,smart_EGF-like_Ca-bd_dom,smart_Notch_dom,smart_Ankyrin_rpt,prints_Notch_3,prints_Notch_dom,pfscan_Ankyrin_rpt,pfscan_Ankyrin_rpt-contain_dom,pfscan_EG-like_dom,pfscan_Notch_dom	-	no_errors	NOTCH3	HGNC	ENSG00000074181	tier1	-	-	36	0	0.00	69	10	12.66	83	0	0.00	64	12	15.79
ATP1A3	0	genome.wustl.edu	37	19	42490069	42490069	+	Missense_Mutation	SNP	C	C	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	19	42490069	42490069	C	A	SNP	ATP1A3	ENST00000302102	human	ensembl	74_37	-1	known	missense	c.553	p.G185C	1.000	pfam_ATPase_P-typ_transduc_dom_A,tigrfam_ATPase_P-typ_Na/K_IIC,tigrfam_Cation_transp_P_typ_ATPase	pfam_ATPase_P-typ_transduc_dom_A,pfam_ATPase_P-typ_cation-transptr_C,pfam_HAD-like_dom,pfam_ATPase_P-typ_cation-transptr_N,superfamily_ATPase_P-typ_cyto_domN,superfamily_HAD-like_dom,smart_ATPase_P-typ_cation-transptr_N,prints_Cation_transp_P_typ_ATPase,tigrfam_ATPase_P-typ_Na/K_IIC,tigrfam_Cation_transp_P_typ_ATPase	-	no_errors	ATP1A3	HGNC	ENSG00000105409	tier1	-	-	65	0	0.00	53	33	38.37	52	0	0.00	50	30	37.50
OR4D11	0	genome.wustl.edu	37	11	59271504	59271504	+	Silent	SNP	C	C	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	11	59271504	59271504	C	A	SNP	OR4D11	ENST00000313253	human	ensembl	74_37	+1	known	silent	c.456	p.G152	0.993	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR4D11	HGNC	ENSG00000176200	tier1	-	-	71	0	0.00	105	10	8.62	75	0	0.00	61	8	11.59
KSR2	0	genome.wustl.edu	37	12	118199247	118199247	+	Silent	SNP	C	C	T			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	12	118199247	118199247	C	T	SNP	KSR2	ENST00000339824	human	ensembl	74_37	-1	known	silent	c.555	p.P185	0.748	NULL	pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Prot_kinase_dom,superfamily_Kinase-like_dom,smart_Prot_Kinase_C-like_PE/DAG-bd,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_Kinase_C-like_PE/DAG-bd,pfscan_Prot_kinase_dom	-	no_errors	KSR2	HGNC	ENSG00000171435	tier1	-	-	70	0	0.00	84	49	36.84	22	0	0.00	14	8	36.36
ATRX	0	genome.wustl.edu	37	X	76909659	76909659	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	X	76909659	76909659	G	A	SNP	ATRX	ENST00000373344	human	ensembl	74_37	-1	known	nonsense	c.4246	p.Q1416*	1.000	NULL	pfam_SNF2_N,pfam_Helicase_C,superfamily_P-loop_NTPase,superfamily_Znf_FYVE_PHD,smart_Helicase_ATP-bd,smart_Helicase_C,pfscan_Helicase_ATP-bd,pfscan_Helicase_C	-	no_errors	ATRX	HGNC	ENSG00000085224	tier1	-	-	19	0	0.00	13	18	58.06	113	0	0.00	70	48	40.68
MED9	0	genome.wustl.edu	37	17	17380342	17380342	+	R	SNP	C	C	G			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	17	17380342	17380342	C	G	SNP	MED9	ENST00000585041	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	MED9	HGNC	ENSG00000141026	tier1	-	-	40	0	0.00	58	9	13.43	22	0	0.00	32	7	17.95
KCNG1	0	genome.wustl.edu	37	20	49626065	49626065	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	20	49626065	49626065	G	A	SNP	KCNG1	ENST00000396017	human	ensembl	74_37	-1	known	nonsense	c.811	p.R271*	0.000	NULL	pfam_T1-type_BTB,superfamily_BTB/POZ_fold,smart_BTB/POZ-like,prints_K_chnl_volt-dep_Kv6,prints_K_chnl_volt-dep_Kv9,prints_K_chnl,prints_K_chnl_volt-dep_Kv3	-	no_errors	KCNG1	HGNC	ENSG00000026559	tier1	-	-	41	0	0.00	60	14	18.92	67	0	0.00	93	11	10.58
PIM2	0	genome.wustl.edu	37	X	48772492	48772492	+	Missense_Mutation	SNP	G	G	T			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	X	48772492	48772492	G	T	SNP	PIM2	ENST00000376509	human	ensembl	74_37	-1	known	missense	c.400	p.P134T	0.943	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_LipoPS_kinase,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_LipoPS_kinase,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	-	no_errors	PIM2	HGNC	ENSG00000102096	tier1	-	-	48	0	0.00	63	23	26.74	54	0	0.00	64	16	20.00
PHC2	0	genome.wustl.edu	37	1	33820033	33820033	+	Silent	SNP	C	C	G			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	1	33820033	33820033	C	G	SNP	PHC2	ENST00000419414	human	ensembl	74_37	-1	known	silent	c.1527	p.T509	1.000	NULL	pfam_SAM_type1,pfam_SAM_2,superfamily_SAM/pointed,smart_SAM,pfscan_SAM,pfscan_Znf_FCS	-	no_errors	PHC2	HGNC	ENSG00000134686	tier1	-	-	68	0	0.00	66	10	13.16	47	0	0.00	38	23	37.70
GPR19	0	genome.wustl.edu	37	12	12815077	12815077	+	Nonsense_Mutation	SNP	G	G	C			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	12	12815077	12815077	G	C	SNP	GPR19	ENST00000332427	human	ensembl	74_37	-1	known	nonsense	c.306	p.Y102*	1.000	pfam_GPCR_Rhodpsn,pfam_7TM_GPCR_olfarory/Srsx,pfscan_GPCR_Rhodpsn_7TM,prints_GPCR_Rhodpsn	pfam_GPCR_Rhodpsn,pfam_7TM_GPCR_olfarory/Srsx,pfscan_GPCR_Rhodpsn_7TM,prints_GPCR_Rhodpsn	-	no_errors	GPR19	HGNC	ENSG00000183150	tier1	-	-	27	0	0.00	43	10	18.87	107	0	0.00	85	15	15.00
TTLL13	0	genome.wustl.edu	37	15	90799414	90799414	+	Missense_Mutation	SNP	G	G	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	15	90799414	90799414	G	A	SNP	TTLL13	ENST00000438251	human	ensembl	74_37	+1	known	missense	c.590	p.R197H	0.975	pfam_TTL/TTLL_fam	pfam_TTL/TTLL_fam	-	no_errors	TTLL13	HGNC	ENSG00000213471	tier1	-	-	37	0	0.00	42	23	35.38	73	0	0.00	57	24	29.63
CNKSR2	0	genome.wustl.edu	37	X	21627458	21627458	+	Missense_Mutation	SNP	G	G	T			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	X	21627458	21627458	G	T	SNP	CNKSR2	ENST00000379510	human	ensembl	74_37	+1	known	missense	c.2415	p.R805S	0.998	NULL	pfam_CNKSR2,pfam_CRIC_domain_Chordata,pfam_SAM_type1,pfam_Pleckstrin_homology,pfam_SAM_2,pfam_PDZ,superfamily_SAM/pointed,superfamily_PDZ,smart_SAM,smart_PDZ,smart_Pleckstrin_homology,pfscan_PDZ,pfscan_Pleckstrin_homology,pfscan_SAM	-	no_errors	CNKSR2	HGNC	ENSG00000149970	tier1	-	-	36	0	0.00	100	16	13.68	33	0	0.00	64	8	11.11
OR10K1	0	genome.wustl.edu	37	1	158435375	158435375	+	Silent	SNP	G	G	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	1	158435375	158435375	G	A	SNP	OR10K1	ENST00000289451	human	ensembl	74_37	+1	known	silent	c.24	p.V8	0.000	NULL	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR10K1	HGNC	ENSG00000173285	tier1	-	-	70	0	0.00	71	12	14.46	25	0	0.00	24	4	14.29
LINGO2	0	genome.wustl.edu	37	9	27949399	27949399	+	Missense_Mutation	SNP	T	T	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	9	27949399	27949399	T	A	SNP	LINGO2	ENST00000308675	human	ensembl	74_37	-1	known	missense	c.1271	p.E424V	1.000	pfam_Ig_I-set,pfam_Ig_V-set,smart_Ig_sub,smart_Ig_sub2,pfscan_Ig-like_dom	pfam_Ig_I-set,pfam_Leu-rich_rpt,pfam_Ig_V-set,pfam_LRR-contain_N,smart_LRR-contain_N,smart_Leu-rich_rpt_typical-subtyp,smart_Ig_sub,smart_Ig_sub2,pfscan_Ig-like_dom	-	no_errors	LINGO2	HGNC	ENSG00000174482	tier1	-	-	46	0	0.00	51	21	29.17	77	0	0.00	66	17	20.48
TXNRD1	0	genome.wustl.edu	37	12	104682750	104682750	+	Missense_Mutation	SNP	G	G	T			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	12	104682750	104682750	G	T	SNP	TXNRD1	ENST00000429002	human	ensembl	74_37	+1	known	missense	c.346	p.A116S	0.485	pfam_Glutaredoxin,superfamily_Thioredoxin-like_fold	pfam_Pyr_nucl-diS_OxRdtase_FAD/D,pfam_Pyr_nucl-diS_OxRdtase_dimer,pfam_Pyr_OxRdtase_D-bd_dom,pfam_FAD_bind_dom,pfam_Glutaredoxin,superfamily_FAD/D-linked_Rdtase_dimer,superfamily_Thioredoxin-like_fold,prints_FAD_pyr_nucl-diS_OxRdtase,prints_Hg_reductase,prints_Pyridine_nuc-diS_OxRdtase_2,tigrfam_Thioredoxin/glutathione_Rdtase	-	no_errors	TXNRD1	HGNC	ENSG00000198431	tier1	-	-	38	0	0.00	43	10	18.87	81	0	0.00	119	26	17.93
KIF1A	0	genome.wustl.edu	37	2	241697823	241697823	+	Missense_Mutation	SNP	C	C	T			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	2	241697823	241697823	C	T	SNP	KIF1A	ENST00000498729	human	ensembl	74_37	-1	known	missense	c.2536	p.G846R	0.997	pfam_KIF1B	pfam_Kinesin_motor_dom,pfam_Kinesin-like,pfam_Pleckstrin_homology,pfam_KIF1B,pfam_FHA_dom,superfamily_P-loop_NTPase,superfamily_SMAD_FHA_domain,smart_Kinesin_motor_dom,smart_FHA_dom,smart_Pleckstrin_homology,pfscan_FHA_dom,pfscan_Pleckstrin_homology,pfscan_Kinesin_motor_dom,prints_Kinesin_motor_dom	-	no_errors	KIF1A	HGNC	ENSG00000130294	tier1	-	-	49	0	0.00	39	23	37.10	22	0	0.00	22	4	15.38
WWP1	0	genome.wustl.edu	37	8	87464902	87464902	+	Missense_Mutation	SNP	A	A	T			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	8	87464902	87464902	A	T	SNP	WWP1	ENST00000265428	human	ensembl	74_37	+1	known	missense	c.2388	p.E796D	0.999	pfam_HECT,superfamily_HECT,smart_HECT,pfscan_HECT	pfam_HECT,pfam_WW_dom,pfam_C2_dom,superfamily_HECT,superfamily_C2_dom,superfamily_WW_dom,smart_C2_dom,smart_WW_dom,smart_HECT,pfscan_HECT,pfscan_C2_dom,pfscan_WW_dom	-	no_errors	WWP1	HGNC	ENSG00000123124	tier1	-	-	64	0	0.00	62	14	18.42	122	0	0.00	86	19	18.10
ZNF99	0	genome.wustl.edu	37	19	22941446	22941446	+	Missense_Mutation	SNP	T	T	C			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	19	22941446	22941446	T	C	SNP	ZNF99	ENST00000397104	human	ensembl	74_37	-1	known	missense	c.992	p.E331G	0.880	pfscan_Znf_C2H2	pfam_Znf_C2H2,pfam_Krueppel-associated_box,superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,smart_Znf_C2H2-like,pfscan_Znf_C2H2,pfscan_Krueppel-associated_box	-	no_errors	ZNF99	HGNC	ENSG00000213973	tier1	-	-	52	0	0.00	75	15	16.67	5	0	0.00	10	2	16.67
NXF1	0	genome.wustl.edu	37	11	62572871	62572871	+	R	SNP	C	C	G			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	11	62572871	62572871	C	G	SNP	NXF1	ENST00000526163	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.001	-	-	-	no_errors	NXF1	HGNC	ENSG00000162231	tier1	-	-	56	0	0.00	49	28	36.36	25	0	0.00	13	7	35.00
CYLC1	0	genome.wustl.edu	37	X	83128692	83128692	+	Missense_Mutation	SNP	G	G	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	X	83128692	83128692	G	A	SNP	CYLC1	ENST00000329312	human	ensembl	74_37	+1	known	missense	c.976	p.V326I	0.196	NULL	NULL	-	no_errors	CYLC1	HGNC	ENSG00000183035	tier1	-	-	20	0	0.00	34	10	22.73	49	0	0.00	89	17	16.04
ZBTB46	0	genome.wustl.edu	37	20	62421656	62421656	+	Missense_Mutation	SNP	C	C	T			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	20	62421656	62421656	C	T	SNP	ZBTB46	ENST00000245663	human	ensembl	74_37	-1	known	missense	c.455	p.S152N	0.265	NULL	pfam_BTB_POZ,pfam_DUF3342,pfam_Znf_C2H2,superfamily_BTB/POZ_fold,smart_BTB/POZ-like,smart_Znf_C2H2-like,pfscan_BTB/POZ-like,pfscan_Znf_C2H2	-	no_errors	ZBTB46	HGNC	ENSG00000130584	tier1	-	-	40	0	0.00	87	37	29.84	10	0	0.00	25	5	16.67
TTC21A	0	genome.wustl.edu	37	3	39172247	39172247	+	Missense_Mutation	SNP	G	G	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	3	39172247	39172247	G	A	SNP	TTC21A	ENST00000301819	human	ensembl	74_37	+1	known	missense	c.2399	p.C800Y	0.906	smart_TPR_repeat,pfscan_TPR-contain_dom	pfam_TPR_1,smart_TPR_repeat,pfscan_TPR_repeat,pfscan_TPR-contain_dom	-	no_errors	TTC21A	HGNC	ENSG00000168026	tier1	-	-	25	0	0.00	22	9	29.03	71	0	0.00	39	18	31.58
POU4F2	0	genome.wustl.edu	37	4	147560580	147560580	+	Silent	SNP	G	G	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	4	147560580	147560580	G	A	SNP	POU4F2	ENST00000281321	human	ensembl	74_37	+1	known	silent	c.288	p.P96	1.000	NULL	pfam_POU_specific,pfam_Homeobox_dom,superfamily_Lambda_D-bd_dom,superfamily_Homeodomain-like,smart_POU_specific,smart_Homeobox_dom,pfscan_Homeobox_dom,pfscan_POU_specific,prints_POU	-	no_errors	POU4F2	HGNC	ENSG00000151615	tier1	-	-	43	0	0.00	34	7	17.07	58	0	0.00	35	16	30.77
TET3	0	genome.wustl.edu	37	2	74273485	74273485	+	Silent	SNP	G	G	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	2	74273485	74273485	G	A	SNP	TET3	ENST00000409262	human	ensembl	74_37	+1	known	silent	c.36	p.R12	1.000	NULL	NULL	-	no_errors	TET3	HGNC	ENSG00000187605	tier1	-	-	42	0	0.00	56	14	20.00	32	0	0.00	24	8	25.00
LPHN2	0	genome.wustl.edu	37	1	82408662	82408662	+	Missense_Mutation	SNP	G	G	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	1	82408662	82408662	G	A	SNP	LPHN2	ENST00000370717	human	ensembl	74_37	+1	known	missense	c.407	p.C136Y	1.000	pfscan_Olfac-like	pfam_GPCR_2_latrophilin_rcpt_C,pfam_Olfac-like,pfam_DUF3497,pfam_GPCR_2_secretin-like,pfam_Lectin_gal-bd_dom,pfam_GPS_dom,pfam_GPCR_2_extracellular_dom,smart_Olfac-like,smart_GPCR_2_extracellular_dom,smart_GPS_dom,prints_GPCR_2_latrophilin,prints_GPCR_2_secretin-like,pfscan_GPS_dom,pfscan_Lectin_gal-bd_dom,pfscan_Olfac-like,pfscan_GPCR_2_extracellular_dom,pfscan_GPCR_2-like	-	no_errors	LPHN2	HGNC	ENSG00000117114	tier1	-	-	69	0	0.00	107	20	15.75	93	1	1.06	79	27	25.47
SFMBT2	0	genome.wustl.edu	37	10	7409806	7409806	+	Missense_Mutation	SNP	C	C	T			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	10	7409806	7409806	C	T	SNP	SFMBT2	ENST00000361972	human	ensembl	74_37	-1	known	missense	c.241	p.E81K	1.000	pfam_Mbt,smart_Mbt,pfscan_Mbt	pfam_Mbt,pfam_DUF3588,pfam_SAM_type1,pfam_Pointed_dom,superfamily_SAM/pointed,superfamily_ARM-type_fold,smart_Mbt,smart_SAM,pfscan_Mbt	-	no_errors	SFMBT2	HGNC	ENSG00000198879	tier1	-	-	30	0	0.00	23	16	41.03	77	0	0.00	44	22	33.33
GIMAP8	0	genome.wustl.edu	37	7	150174547	150174547	+	Silent	SNP	C	C	T			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	7	150174547	150174547	C	T	SNP	GIMAP8	ENST00000307271	human	ensembl	74_37	+1	known	silent	c.1677	p.Y559	0.009	pfam_AIG1,superfamily_P-loop_NTPase	pfam_AIG1,superfamily_P-loop_NTPase	-	no_errors	GIMAP8	HGNC	ENSG00000171115	tier1	-	-	22	0	0.00	47	12	20.34	158	0	0.00	112	23	17.04
LAMB1	0	genome.wustl.edu	37	7	107626774	107626774	+	Missense_Mutation	SNP	G	G	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	7	107626774	107626774	G	A	SNP	LAMB1	ENST00000222399	human	ensembl	74_37	-1	known	missense	c.458	p.S153L	1.000	pfam_Laminin_N,smart_Laminin_N,pfscan_Laminin_N	pfam_EGF_laminin,pfam_Laminin_N,superfamily_Prefoldin,superfamily_t-SRE,superfamily_P-loop_NTPase,smart_Laminin_N,smart_EGF_laminin,smart_EG-like_dom,pfscan_Laminin_IV,pfscan_EGF_laminin,pfscan_Laminin_N	-	no_errors	LAMB1	HGNC	ENSG00000091136	tier1	-	-	44	0	0.00	63	12	16.00	117	0	0.00	108	26	19.40
ATRX	0	genome.wustl.edu	37	X	76761237	76761237	+	R	SNP	A	A	C			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	A	A	A	C	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	X	76761237	76761237	A	C	SNP	ATRX	ENST00000480283	human	ensembl	74_37	-1	known	rna	NULL	NULL	1.000	-	-	-	no_errors	ATRX	HGNC	ENSG00000085224	tier1	-	-	32	0	0.00	41	6	12.77	81	0	0.00	57	11	16.18
OR4A47	0	genome.wustl.edu	37	11	48510419	48510419	+	Silent	SNP	T	T	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	11	48510419	48510419	T	A	SNP	OR4A47	ENST00000446524	human	ensembl	74_37	+1	known	silent	c.75	p.L25	0.000	prints_GPCR_Rhodpsn	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR4A47	HGNC	ENSG00000237388	tier1	-	-	72	0	0.00	47	52	52.53	42	0	0.00	36	32	46.38
MYH9	0	genome.wustl.edu	37	22	36678786	36678786	+	Silent	SNP	T	T	C			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	22	36678786	36678786	T	C	SNP	MYH9	ENST00000216181	human	ensembl	74_37	-1	known	silent	c.5811	p.K1937	0.997	NULL	pfam_Myosin_head_motor_dom,pfam_Myosin_tail,pfam_Myosin_N,pfam_IQ_motif_EF-hand-BS,superfamily_P-loop_NTPase,superfamily_Regulat_G_prot_signal_superfam,superfamily_Prefoldin,superfamily_Myosin_S1_N,superfamily_STAT_TF_coiled-coil,superfamily_tR-bd_arm,smart_Myosin_head_motor_dom,smart_IQ_motif_EF-hand-BS,pfscan_IQ_motif_EF-hand-BS,prints_Myosin_head_motor_dom	-	no_errors	MYH9	HGNC	ENSG00000100345	tier1	rs139624264	-	64	0	0.00	23	59	71.95	27	0	0.00	15	31	67.39
ATRX	0	genome.wustl.edu	37	X	76855962	76855962	+	Missense_Mutation	SNP	T	T	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	X	76855962	76855962	T	A	SNP	ATRX	ENST00000373344	human	ensembl	74_37	-1	known	missense	c.5638	p.S1880C	1.000	pfam_SNF2_N,superfamily_P-loop_NTPase	pfam_SNF2_N,pfam_Helicase_C,superfamily_P-loop_NTPase,superfamily_Znf_FYVE_PHD,smart_Helicase_ATP-bd,smart_Helicase_C,pfscan_Helicase_ATP-bd,pfscan_Helicase_C	-	no_errors	ATRX	HGNC	ENSG00000085224	tier1	-	-	91	0	0.00	87	19	17.92	121	0	0.00	85	24	22.02
CYP2C9	0	genome.wustl.edu	37	10	96731898	96731898	+	Missense_Mutation	SNP	G	G	T			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	10	96731898	96731898	G	T	SNP	CYP2C9	ENST00000260682	human	ensembl	74_37	+1	known	missense	c.857	p.S286I	0.766	pfam_Cyt_P450,superfamily_Cyt_P450,prints_Cyt_P450_E_grp-I,prints_Cyt_P450_B	pfam_Cyt_P450,superfamily_Cyt_P450,prints_Cyt_P450_E_grp-I,prints_Cyt_P450,prints_Cyt_P450_E_grp-IV,prints_Cyt_P450_B	-	no_errors	CYP2C9	HGNC	ENSG00000138109	tier1	-	-	85	0	0.00	59	15	20.27	44	0	0.00	28	5	15.15
OR5L1	0	genome.wustl.edu	37	11	55579035	55579035	+	Silent	SNP	C	C	T			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	11	55579035	55579035	C	T	SNP	OR5L1	ENST00000333973	human	ensembl	74_37	+1	known	silent	c.93	p.F31	0.000	prints_GPCR_Rhodpsn	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR5L1	HGNC	ENSG00000186117	tier1	-	-	92	0	0.00	68	22	24.44	38	0	0.00	24	5	17.24
L1CAM	0	genome.wustl.edu	37	X	153135044	153135044	+	Missense_Mutation	SNP	T	T	C			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	X	153135044	153135044	T	C	SNP	L1CAM	ENST00000543994	human	ensembl	74_37	-1	known	missense	c.1204	p.M402V	0.947	pfam_Ig_I-set,smart_Ig_sub,smart_Ig_sub2,pfscan_Ig-like_dom	pfam_Ig_I-set,pfam_Fibronectin_type3,pfam_Immunoglobulin,superfamily_Fibronectin_type3,smart_Ig_sub,smart_Ig_sub2,smart_Fibronectin_type3,pfscan_Fibronectin_type3,pfscan_Ig-like_dom	-	no_errors	L1CAM	HGNC	ENSG00000198910	tier1	-	-	65	0	0.00	82	27	24.55	59	0	0.00	69	11	13.75
AOX1	0	genome.wustl.edu	37	2	201521613	201521613	+	Missense_Mutation	SNP	C	C	T			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	2	201521613	201521613	C	T	SNP	AOX1	ENST00000374700	human	ensembl	74_37	+1	known	missense	c.3124	p.H1042Y	1.000	pfam_AldOxase/xan_DH_Mopterin-bd,superfamily_AldOxase/xan_DH_Mopterin-bd,pirsf_Ald_Oxase/xanthine_DH,tigrfam_Aldehyde_oxidase	pfam_AldOxase/xan_DH_Mopterin-bd,pfam_Mopterin_DH_FAD-bd,pfam_Ald_Oxase/Xan_DH_a/b,pfam_2Fe-2S-bd,pfam_CO_DH_flav_C,pfam_2Fe-2S_ferredoxin-type,superfamily_AldOxase/xan_DH_Mopterin-bd,superfamily_FAD-bd_2,superfamily_Ald_Oxase/Xan_DH_a/b,superfamily_2Fe-2S-bd,superfamily_CO_DH_flav_C,superfamily_2Fe-2S_ferredoxin-type,pirsf_Ald_Oxase/xanthine_DH,pfscan_2Fe-2S_ferredoxin-type,tigrfam_Aldehyde_oxidase	-	no_errors	AOX1	HGNC	ENSG00000138356	tier1	-	-	67	0	0.00	41	19	31.67	69	0	0.00	47	13	21.67
FUNDC2P2	0	genome.wustl.edu	37	2	84517888	84517888	+	R	SNP	G	G	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	2	84517888	84517888	G	A	SNP	FUNDC2P2	ENST00000331369	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.001	-	-	-	no_errors	FUNDC2P2	HGNC	ENSG00000182814	tier1	-	-	38	0	0.00	36	11	23.40	41	0	0.00	25	8	24.24
TULP4	0	genome.wustl.edu	37	6	158924151	158924151	+	Silent	SNP	T	T	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	6	158924151	158924151	T	A	SNP	TULP4	ENST00000367097	human	ensembl	74_37	+1	known	silent	c.3456	p.S1152	1.000	NULL	pfam_Tubby_C,pfam_SOCS_C,pfam_WD40_repeat,superfamily_Tubby_C-like,superfamily_WD40_repeat_dom,superfamily_Tumour_necrosis_fac-like_dom,smart_WD40_repeat,smart_SOCS_C,pfscan_SOCS_C,pfscan_WD40_repeat,pfscan_WD40_repeat_dom	-	no_errors	TULP4	HGNC	ENSG00000130338	tier1	-	-	57	0	0.00	56	16	22.22	85	0	0.00	77	33	29.73
RPL7	0	genome.wustl.edu	37	8	74203808	74203808	+	Missense_Mutation	SNP	C	C	T			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	8	74203808	74203808	C	T	SNP	RPL7	ENST00000352983	human	ensembl	74_37	-1	known	missense	c.517	p.A173T	0.000	superfamily_Ribosomal_L30_ferredoxin-like,tigrfam_Ribosomal_L7_euk	pfam_Ribosomal_L30_N,pfam_Ribosomal_L30_ferredoxin-like,superfamily_Ribosomal_L30_ferredoxin-like,tigrfam_Ribosomal_L7_euk	-	no_errors	RPL7	HGNC	ENSG00000147604	tier1	-	-	55	0	0.00	46	12	20.69	29	0	0.00	22	5	18.52
TP53	0	genome.wustl.edu	37	17	7578211	7578211	+	Missense_Mutation	SNP	C	C	G			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	17	7578211	7578211	C	G	SNP	TP53	ENST00000269305	human	ensembl	74_37	-1	known	missense	c.638	p.R213P	0.935	pfam_p53_D-bd,superfamily_p53-like_TF_D-bd,prints_p53_tumour_suppressor	pfam_p53_D-bd,pfam_p53_tetrameristn,pfam_p53_transactivation_domain,superfamily_p53-like_TF_D-bd,superfamily_p53_tetrameristn,prints_p53_tumour_suppressor	-	no_errors	TP53	HGNC	ENSG00000141510	tier1	-	-	59	0	0.00	23	36	61.02	90	0	0.00	59	58	49.57
CAC1D	0	genome.wustl.edu	37	3	53837530	53837530	+	Frame_Shift_Del	DEL	G	G	-			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G	G	-	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	3	53837530	53837530	G	-	DEL	CAC1D	ENST00000288139	human	ensembl	74_37	+1	known	frame_shift_del	c.5576	p.C1859fs	0.908	NULL	pfam_Ion_trans_dom,pfam_VDCC_a1su_IQ,pfam_PKD1_2_channel,prints_VDCCAlpha1,prints_VDCC_L_a1su,prints_LVDCC_a1dsu	-	no_errors	CAC1D	HGNC	ENSG00000157388	tier1			48	0	0.00	25	8	24.24	52	0	0.00	34	18	34.62
SCARF2	0	genome.wustl.edu	37	22	20780112	20780112	+	Silent	SNP	G	G	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	22	20780112	20780112	G	A	SNP	SCARF2	ENST00000405555	human	ensembl	74_37	-1	known	silent	c.2151	p.R717	0.100	NULL	pfam_EGF_laminin,superfamily_Growth_fac_rcpt_N_dom,smart_EGF_laminin,smart_EG-like_dom,pfscan_EG-like_dom	-	no_errors	SCARF2	HGNC	ENSG00000244486	tier1	-	-	13	0	0.00	3	9	75.00	12	0	0.00	3	2	40.00
MRGPRX3	0	genome.wustl.edu	37	11	18159293	18159293	+	Missense_Mutation	SNP	G	G	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	11	18159293	18159293	G	A	SNP	MRGPRX3	ENST00000396275	human	ensembl	74_37	+1	known	missense	c.544	p.A182T	0.000	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_GPCR_Rhodpsn	-	no_errors	MRGPRX3	HGNC	ENSG00000179826	tier1	-	-	111	0	0.00	228	22	8.80	51	0	0.00	97	10	9.35
KALRN	0	genome.wustl.edu	37	3	124436186	124436186	+	Missense_Mutation	SNP	C	C	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	3	124436186	124436186	C	A	SNP	KALRN	ENST00000360013	human	ensembl	74_37	+1	known	missense	c.8369	p.A2790D	1.000	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	pfam_DH-domain,pfam_Prot_kinase_dom,pfam_Spectrin_repeat,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Ig_I-set,pfam_Fibronectin_type3,pfam_Ig_V-set,pfam_Immunoglobulin,superfamily_Kinase-like_dom,superfamily_DH-domain,superfamily_Fibronectin_type3,superfamily_SH3_domain,superfamily_CRAL-TRIO_dom,smart_CRAL-TRIO_dom,smart_Spectrin/alpha-actinin,smart_DH-domain,smart_Pleckstrin_homology,smart_SH3_domain,smart_Ig_sub,smart_Ig_sub2,smart_Fibronectin_type3,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_CRAL-TRIO_dom,pfscan_Fibronectin_type3,pfscan_Pleckstrin_homology,pfscan_SH3_domain,pfscan_Prot_kinase_dom,pfscan_Ig-like_dom,pfscan_DH-domain	-	no_errors	KALRN	HGNC	ENSG00000160145	tier1	-	-	18	0	0.00	16	12	42.86	63	0	0.00	56	4	6.67
C9orf72	0	genome.wustl.edu	37	9	27566948	27566948	+	Silent	SNP	T	T	C			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	9	27566948	27566948	T	C	SNP	C9orf72	ENST00000380003	human	ensembl	74_37	-1	known	silent	c.171	p.G57	1.000	NULL	NULL	-	no_errors	C9orf72	HGNC	ENSG00000147894	tier1	-	-	35	0	0.00	38	4	9.52	98	1	1.01	117	12	9.30
FBXW5	0	genome.wustl.edu	37	9	139835424	139835424	+	Missense_Mutation	SNP	G	G	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	9	139835424	139835424	G	A	SNP	FBXW5	ENST00000325285	human	ensembl	74_37	-1	known	missense	c.1657	p.R553W	0.110	NULL	pfam_WD40_repeat,pfam_F-box_dom,superfamily_Quinoprot_gluc/sorb_DH,superfamily_F-box_dom,smart_F-box_dom,smart_WD40_repeat,pfscan_F-box_dom,pfscan_WD40_repeat,pfscan_WD40_repeat_dom	-	no_errors	FBXW5	HGNC	ENSG00000159069	tier1	-	-	42	0	0.00	74	14	15.91	5	0	0.00	0	0	0.00
PLEKHG6	0	genome.wustl.edu	37	12	6437043	6437043	+	Missense_Mutation	SNP	T	T	G			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	12	6437043	6437043	T	G	SNP	PLEKHG6	ENST00000011684	human	ensembl	74_37	+1	known	missense	c.2294	p.L765R	1.000	NULL	pfam_DH-domain,superfamily_DH-domain,smart_DH-domain,smart_Pleckstrin_homology,pfscan_Pleckstrin_homology,pfscan_DH-domain	-	no_errors	PLEKHG6	HGNC	ENSG00000008323	tier1	-	-	21	0	0.00	30	14	31.82	5	0	0.00	0	1	100.00
TUBB2A	0	genome.wustl.edu	37	6	3155012	3155012	+	Silent	SNP	G	G	A			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	6	3155012	3155012	G	A	SNP	TUBB2A	ENST00000333628	human	ensembl	74_37	-1	known	silent	c.423	p.G141	0.001	pfam_Tubulin_FtsZ_GTPase,superfamily_Tubulin_FtsZ_GTPase,smart_Tubulin_FtsZ_GTPase,prints_Tubulin,prints_Epsilon_tubulin	pfam_Tubulin_FtsZ_GTPase,pfam_Tubulin/FtsZ_2-layer-sand-dom,pfam_Misato_II_tubulin-like,superfamily_Tubulin_FtsZ_GTPase,superfamily_Tub_FtsZ_C,smart_Tubulin_FtsZ_GTPase,smart_Tubulin/FtsZ_2-layer-sand-dom,prints_Beta_tubulin,prints_Tubulin,prints_Epsilon_tubulin,prints_Gamma_tubulin,prints_Delta_tubulin,prints_Alpha_tubulin	-	no_errors	TUBB2A	HGNC	ENSG00000137267	tier1	-	-	32	0	0.00	60	7	10.45	6	0	0.00	2	1	33.33
DNM1P47	0	genome.wustl.edu	37	15	102298070	102298070	+	R	SNP	C	C	T			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	15	102298070	102298070	C	T	SNP	DNM1P47	ENST00000561463	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.995	-	-	-	no_errors	DNM1P47	HGNC	ENSG00000259660	tier1	rs199907203	-	28	0	0.00	10	10	50.00	2	0	0.00	0	0	0.00
ENSG00000215958	0	genome.wustl.edu	37	15	70077755	70077756	+	R	INS	-	-	TGTGTG			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	-	-					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	15	70077755	70077756	-	TGTGTG	INS	ENSG00000215958	ENST00000401139	human	ensembl	74_37	-1	novel	rna	NULL	NULL	0.176:0.181	-	-	-	no_errors	AC021818.1	Clone_based_ensembl_gene	ENSG00000215958	tier1			0	0	0.00	0	0	0.00	0	0	0.00	0	0	0.00
LRRC30	0	genome.wustl.edu	37	18	7231238	7231238	+	Silent	SNP	G	G	T			TCGA-IE-A4EJ-01A-11D-A24N-09	TCGA-IE-A4EJ-10A-01D-A24N-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	3a097f74-2fe0-4c33-93cc-2ec39b24c839	8eab9939-2bfb-45c0-9a2d-57ea334820f8	18	7231238	7231238	G	T	SNP	LRRC30	ENST00000383467	human	ensembl	74_37	+1	known	silent	c.102	p.L34	0.693	NULL	pfam_Leu-rich_rpt,smart_Leu-rich_rpt_typical-subtyp	-	no_errors	LRRC30	HGNC	ENSG00000206422	tier1	-	-	40	0	0.00	46	7	13.21	63	0	0.00	68	2	2.86