Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_Position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_File	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	chromosome_name	start	stop	reference	variant	type	gene_name	transcript_name	transcript_species	transcript_source	transcript_version	strand	transcript_status	trv_type	c_position	amino_acid_change	ucsc_cons	domain	all_domains	deletion_substructures	transcript_error	default_gene_name	gene_name_source	 ensembl_gene_id	tier	dbSNP	GMAF	n_ref_count	n_alt_count	normal_vaf	t_ref_count	t_alt_count	tumor_vaf	n_ref_count_val	n_alt_count_val	normal_vaf_val	t_ref_count_val	t_alt_count_val	tumor_vaf_val
ACTL9	0	genome.wustl.edu	37	19	8807881	8807881	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	19	8807881	8807881	G	A	SNP	ACTL9	ENST00000324436	human	ensembl	74_37	-1	known	missense	c.1171	p.R391C	0.994	pfam_Actin-related,smart_Actin-related	pfam_Actin-related,smart_Actin-related,prints_Actin-related	-	no_errors	ACTL9	HGNC	ENSG00000181786	tier1	-	-	52	0	0.00	35	19	35.19	33	0	0.00	31	30	49.18
ZNF430	0	genome.wustl.edu	37	19	21216935	21216935	+	Missense_Mutation	SNP	G	G	C			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	19	21216935	21216935	G	C	SNP	ZNF430	ENST00000261560	human	ensembl	74_37	+1	known	missense	c.267	p.E89D	0.225	superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,pfscan_Krueppel-associated_box	pfam_Znf_C2H2,pfam_Krueppel-associated_box,superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,smart_Znf_C2H2-like,pfscan_Znf_C2H2,pfscan_Krueppel-associated_box	-	no_errors	ZNF430	HGNC	ENSG00000118620	tier1	-	-	70	0	0.00	31	23	42.59	42	0	0.00	27	20	42.55
C4orf22	0	genome.wustl.edu	37	4	81504291	81504291	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	4	81504291	81504291	C	T	SNP	C4orf22	ENST00000508675	human	ensembl	74_37	+1	known	missense	c.287	p.T96M	1.000	NULL	NULL	-	no_errors	C4orf22	HGNC	ENSG00000197826	tier1	rs142731425	GMAF=0.0005	44	0	0.00	6	11	61.11	103	0	0.00	37	40	51.95
CCDC22	0	genome.wustl.edu	37	X	49106184	49106184	+	Missense_Mutation	SNP	C	C	A			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	X	49106184	49106184	C	A	SNP	CCDC22	ENST00000376227	human	ensembl	74_37	+1	known	missense	c.1768	p.Q590K	1.000	pfam_DUF812	pfam_DUF812	-	no_errors	CCDC22	HGNC	ENSG00000101997	tier1	-	-	81	0	0.00	49	31	38.75	17	0	0.00	13	4	23.53
ANGEL2	0	genome.wustl.edu	37	1	213168525	213168525	+	Missense_Mutation	SNP	A	A	G			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	1	213168525	213168525	A	G	SNP	ANGEL2	ENST00000366962	human	ensembl	74_37	-1	known	missense	c.1493	p.V498A	0.015	pfam_Endo/exonuclease/phosphatase,superfamily_Endo/exonuclease/phosphatase	pfam_Endo/exonuclease/phosphatase,superfamily_Endo/exonuclease/phosphatase	-	no_errors	ANGEL2	HGNC	ENSG00000174606	tier1	-	-	29	0	0.00	29	12	29.27	129	0	0.00	103	51	33.12
FXR2	0	genome.wustl.edu	37	17	7496167	7496167	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	17	7496167	7496167	G	A	SNP	FXR2	ENST00000250113	human	ensembl	74_37	-1	known	missense	c.1574	p.S525F	0.997	pfam_Frag_X_MRP_fam	pfam_Frag_X_MRP_fam,pfam_KH_dom_type_1,pfam_Agenet-like_dom,smart_KH_dom,pfscan_KH_dom_type_1	-	no_errors	FXR2	HGNC	ENSG00000129245	tier1	-	-	22	0	0.00	10	32	76.19	58	0	0.00	12	36	75.00
PARL	0	genome.wustl.edu	37	3	183551567	183551567	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	3	183551567	183551567	G	A	SNP	PARL	ENST00000317096	human	ensembl	74_37	-1	known	missense	c.875	p.P292L	1.000	pfam_Peptidase_S54_rhomboid_dom	pfam_Peptidase_S54_rhomboid_dom	-	no_errors	PARL	HGNC	ENSG00000175193	tier1	-	-	30	0	0.00	12	5	29.41	73	0	0.00	37	28	43.08
ABCB10	0	genome.wustl.edu	37	1	229667402	229667402	+	Silent	SNP	C	C	T			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	1	229667402	229667402	C	T	SNP	ABCB10	ENST00000344517	human	ensembl	74_37	-1	known	silent	c.1416	p.E472	0.996	superfamily_ABC1_TM_dom	pfam_ABC_transptr_TM_dom,pfam_ABC_transporter-like,superfamily_ABC1_TM_dom,superfamily_P-loop_NTPase,smart_AAA+_ATPase,pfscan_ABC_transporter-like,pfscan_ABC1_TM_dom	-	no_errors	ABCB10	HGNC	ENSG00000135776	tier1	-	-	55	0	0.00	35	23	39.66	45	0	0.00	32	12	27.27
TRPV6	0	genome.wustl.edu	37	7	142571440	142571440	+	Missense_Mutation	SNP	G	G	T			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	7	142571440	142571440	G	T	SNP	TRPV6	ENST00000359396	human	ensembl	74_37	-1	known	missense	c.1549	p.P517T	1.000	pfam_Ion_trans_dom,tigrfam_TRP_channel	pfam_Ankyrin_rpt,pfam_Ion_trans_dom,superfamily_Ankyrin_rpt-contain_dom,smart_Ankyrin_rpt,pfscan_Ankyrin_rpt,pfscan_Ankyrin_rpt-contain_dom,prints_TRPV5/TRPV6,prints_TRPV6_channel,prints_Ankyrin_rpt,tigrfam_TRP_channel	-	no_errors	TRPV6	HGNC	ENSG00000165125	tier1	-	-	26	0	0.00	15	14	48.28	91	0	0.00	59	46	43.81
MYO1E	0	genome.wustl.edu	37	15	59470648	59470648	+	Missense_Mutation	SNP	C	C	A			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	15	59470648	59470648	C	A	SNP	MYO1E	ENST00000288235	human	ensembl	74_37	-1	known	missense	c.1993	p.D665Y	1.000	pfam_Myosin_head_motor_dom,superfamily_P-loop_NTPase,smart_Myosin_head_motor_dom	pfam_Myosin_head_motor_dom,pfam_Myosin_tail_2,pfam_SH3_domain,pfam_SH3_2,superfamily_P-loop_NTPase,superfamily_SH3_domain,smart_Myosin_head_motor_dom,smart_SH3_domain,pfscan_IQ_motif_EF-hand-BS,pfscan_SH3_domain,prints_Myosin_head_motor_dom,prints_SH3_domain	-	no_errors	MYO1E	HGNC	ENSG00000157483	tier1	-	-	53	0	0.00	44	18	29.03	64	0	0.00	60	34	36.17
ENSG00000252677	0	genome.wustl.edu	37	18	19292022	19292022	+	R	SNP	A	A	C			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	A	A	A	C	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	18	19292022	19292022	A	C	SNP	ENSG00000252677	ENST00000516868	human	ensembl	74_37	-1	novel	rna	NULL	NULL	0.991	-	-	-	no_errors	SNORA81	RFAM	ENSG00000252677	tier1	-	-	32	0	0.00	16	9	36.00	106	0	0.00	82	47	36.43
PYGM	0	genome.wustl.edu	37	11	64518806	64518806	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	11	64518806	64518806	C	T	SNP	PYGM	ENST00000164139	human	ensembl	74_37	-1	known	missense	c.1960	p.A654T	1.000	pfam_Glyco_trans_35,pirsf_Glyco_trans_35,tigrfam_Glycg_phsphrylas	pfam_Glyco_trans_35,pirsf_Glyco_trans_35,tigrfam_Glycg_phsphrylas	-	no_errors	PYGM	HGNC	ENSG00000068976	tier1	-	-	23	0	0.00	12	10	45.45	100	0	0.00	28	31	52.54
NRP2	0	genome.wustl.edu	37	2	206588537	206588537	+	Silent	SNP	G	G	T			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	2	206588537	206588537	G	T	SNP	NRP2	ENST00000360409	human	ensembl	74_37	+1	known	silent	c.693	p.G231	0.962	pirsf_Neuropilin,pfam_CUB_dom,superfamily_CUB_dom,smart_CUB_dom,pfscan_CUB_dom	pirsf_Neuropilin,pfam_CUB_dom,pfam_Coagulation_fac_5/8-C_type_dom,pfam_MAM_dom,pfam_Neuropilin1_C,superfamily_Galactose-bd-like,superfamily_CUB_dom,superfamily_ConA-like_lec_gl_sf,smart_CUB_dom,smart_Coagulation_fac_5/8-C_type_dom,smart_MAM_dom,prints_MAM_dom,pfscan_CUB_dom,pfscan_Coagulation_fac_5/8-C_type_dom,pfscan_MAM_dom	-	no_errors	NRP2	HGNC	ENSG00000118257	tier1	-	-	60	0	0.00	25	11	30.56	134	0	0.00	69	58	45.67
IL2RG	0	genome.wustl.edu	37	X	70328508	70328508	+	Missense_Mutation	SNP	G	G	C			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	X	70328508	70328508	G	C	SNP	IL2RG	ENST00000374202	human	ensembl	74_37	-1	known	missense	c.795	p.I265M	0.918	NULL	pfam_IL-6_rcpt_alpha-bd,pfam_Fibronectin_type3,superfamily_Fibronectin_type3,pfscan_Fibronectin_type3	-	no_errors	IL2RG	HGNC	ENSG00000147168	tier1	-	-	20	0	0.00	17	9	34.62	152	0	0.00	98	52	34.44
PAPOLB	0	genome.wustl.edu	37	7	4901098	4901098	+	Missense_Mutation	SNP	A	A	G			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	7	4901098	4901098	A	G	SNP	PAPOLB	ENST00000404991	human	ensembl	74_37	-1	known	missense	c.341	p.I114T	1.000	pfam_PolA_pol_cen_dom,pfam_Nucleotidyltransferase,pirsf_PolyA_polymerase	pfam_PolA_pol_cen_dom,pfam_PolA_pol_R-bd_dom,pfam_Nucleotidyltransferase,superfamily_NuclTrfase_I_C,pirsf_PolyA_polymerase	-	no_errors	PAPOLB	HGNC	ENSG00000218823	tier1	-	-	35	0	0.00	10	5	33.33	96	0	0.00	52	43	45.26
ATRX	0	genome.wustl.edu	37	X	76939577	76939577	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	X	76939577	76939577	G	A	SNP	ATRX	ENST00000373344	human	ensembl	74_37	-1	known	nonsense	c.1171	p.Q391*	1.000	NULL	pfam_SNF2_N,pfam_Helicase_C,superfamily_P-loop_NTPase,superfamily_Znf_FYVE_PHD,smart_Helicase_ATP-bd,smart_Helicase_C,pfscan_Helicase_ATP-bd,pfscan_Helicase_C	-	no_errors	ATRX	HGNC	ENSG00000085224	tier1	-	-	51	0	0.00	16	12	42.86	155	0	0.00	51	60	54.05
INTS5	0	genome.wustl.edu	37	11	62415487	62415487	+	Silent	SNP	G	G	A			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	11	62415487	62415487	G	A	SNP	INTS5	ENST00000330574	human	ensembl	74_37	-1	known	silent	c.2065	p.L689	0.999	NULL	NULL	-	no_errors	INTS5	HGNC	ENSG00000185085	tier1	-	-	40	0	0.00	26	8	23.53	64	0	0.00	38	20	34.48
XKR4	0	genome.wustl.edu	37	8	56436473	56436473	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	8	56436473	56436473	G	A	SNP	XKR4	ENST00000327381	human	ensembl	74_37	+1	known	missense	c.1640	p.R547Q	1.000	NULL	pfam_Transport_prot_XK	-	no_errors	XKR4	HGNC	ENSG00000206579	tier1	-	-	44	0	0.00	25	9	26.47	44	0	0.00	37	15	28.85
PEX5L	0	genome.wustl.edu	37	3	179525571	179525571	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	3	179525571	179525571	G	A	SNP	PEX5L	ENST00000467460	human	ensembl	74_37	-1	known	missense	c.1567	p.R523C	1.000	pfam_TPR_1,smart_TPR_repeat,pfscan_TPR_repeat,pfscan_TPR-contain_dom	pfam_TPR_1,smart_TPR_repeat,pfscan_TPR_repeat,pfscan_TPR-contain_dom	-	no_errors	PEX5L	HGNC	ENSG00000114757	tier1	-	-	27	0	0.00	29	7	19.44	38	0	0.00	44	9	16.98
PPP2R3A	0	genome.wustl.edu	37	3	135806749	135806749	+	Missense_Mutation	SNP	G	G	T			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	3	135806749	135806749	G	T	SNP	PPP2R3A	ENST00000264977	human	ensembl	74_37	+1	known	missense	c.2813	p.R938M	1.000	NULL	pfscan_EF_hand_dom	-	no_errors	PPP2R3A	HGNC	ENSG00000073711	tier1	-	-	46	0	0.00	21	17	44.74	97	0	0.00	63	41	39.42
C2orf74	0	genome.wustl.edu	37	2	61391639	61391639	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	2	61391639	61391639	C	T	SNP	C2orf74	ENST00000432605	human	ensembl	74_37	+1	known	nonsense	c.562	p.R188*	0.001	NULL	NULL	-	no_errors	C2orf74	HGNC	ENSG00000237651	tier1	-	-	39	0	0.00	21	7	25.00	124	0	0.00	105	55	34.38
FANCB	0	genome.wustl.edu	37	X	14862776	14862776	+	Missense_Mutation	SNP	T	T	A			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	X	14862776	14862776	T	A	SNP	FANCB	ENST00000324138	human	ensembl	74_37	-1	known	missense	c.2014	p.M672L	0.000	NULL	NULL	-	no_errors	FANCB	HGNC	ENSG00000181544	tier1	-	-	64	0	0.00	36	14	28.00	97	0	0.00	76	31	28.97
MTHFSD	0	genome.wustl.edu	37	16	86575760	86575760	+	Missense_Mutation	SNP	T	T	A			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	16	86575760	86575760	T	A	SNP	MTHFSD	ENST00000360900	human	ensembl	74_37	-1	known	missense	c.502	p.M168L	0.994	pfam_FTHF_cligase	pfam_FTHF_cligase,pfam_RRM_dom,smart_RRM_dom,pfscan_RRM_dom	-	no_errors	MTHFSD	HGNC	ENSG00000103248	tier1	-	-	15	0	0.00	8	10	55.56	37	0	0.00	21	18	46.15
TPTE2P5	0	genome.wustl.edu	37	13	41429945	41429945	+	R	SNP	C	C	A			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	13	41429945	41429945	C	A	SNP	TPTE2P5	ENST00000379515	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.334	-	-	-	no_errors	TPTE2P5	HGNC	ENSG00000168852	tier1	-	-	53	0	0.00	80	35	30.43	94	0	0.00	161	75	31.65
SND1	0	genome.wustl.edu	37	7	127721533	127721533	+	Missense_Mutation	SNP	A	A	C			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	A	A	A	C	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	7	127721533	127721533	A	C	SNP	SND1	ENST00000354725	human	ensembl	74_37	+1	known	missense	c.2090	p.Y697S	0.997	pfam_Tudor,pirsf_Silence_cplx_Nase-comp_TudorSN	pfam_Staphylococal_nuclease_OB-fold,pfam_Tudor,superfamily_Staphylococal_nuclease_OB-fold,smart_Staphylococal_nuclease_OB-fold,smart_Tudor,pirsf_Silence_cplx_Nase-comp_TudorSN,pfscan_Tudor,pfscan_Staphylococal_nuclease_OB-fold	-	no_errors	SND1	HGNC	ENSG00000197157	tier1	-	-	32	0	0.00	15	10	40.00	64	0	0.00	47	24	33.80
SERPINF2	0	genome.wustl.edu	37	17	1657814	1657814	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	17	1657814	1657814	G	A	SNP	SERPINF2	ENST00000324015	human	ensembl	74_37	+1	known	missense	c.1462	p.G488S	0.000	NULL	pfam_Serpin_dom,superfamily_Serpin_dom,smart_Serpin_dom	-	no_errors	SERPINF2	HGNC	ENSG00000167711	tier1	-	-	18	0	0.00	2	11	84.62	105	1	0.93	25	60	70.59
CRAT	0	genome.wustl.edu	37	9	131871486	131871486	+	Missense_Mutation	SNP	T	T	A			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	9	131871486	131871486	T	A	SNP	CRAT	ENST00000441796	human	ensembl	74_37	-1	known	missense	c.98	p.H33L	0.001	NULL	NULL	-	no_errors	CRAT	HGNC	ENSG00000095321	tier1	-	-	17	0	0.00	24	10	29.41	108	0	0.00	77	38	32.76
IGDCC3	0	genome.wustl.edu	37	15	65628224	65628224	+	Silent	SNP	G	G	A			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	15	65628224	65628224	G	A	SNP	IGDCC3	ENST00000327987	human	ensembl	74_37	-1	known	silent	c.480	p.C160	1.000	pfam_Ig_I-set,smart_Ig_sub,smart_Ig_sub2,pfscan_Ig-like_dom	pfam_Ig_I-set,pfam_Immunoglobulin,pfam_Fibronectin_type3,pfam_Ig_V-set,superfamily_Fibronectin_type3,smart_Ig_sub,smart_Ig_sub2,smart_Fibronectin_type3,pfscan_Fibronectin_type3,pfscan_Ig-like_dom	-	no_errors	IGDCC3	HGNC	ENSG00000174498	tier1	-	-	33	0	0.00	19	12	38.71	104	0	0.00	57	26	31.33
TMTC3	0	genome.wustl.edu	37	12	88589095	88589095	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	A	A	A	-	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	12	88589095	88589095	A	-	DEL	TMTC3	ENST00000266712	human	ensembl	74_37	+1	known	frame_shift_del	c.2414	p.E805fs	1.000	NULL	pfam_TPR_2,pfam_TPR_1,pfam_DUF1736,smart_TPR_repeat,pfscan_TPR_repeat,pfscan_TPR-contain_dom	-	no_errors	TMTC3	HGNC	ENSG00000139324	tier1			33	0	0.00	15	4	21.05	57	0	0.00	59	9	13.24
TNXB	0	genome.wustl.edu	37	6	32023775	32023775	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	6	32023775	32023775	C	T	SNP	TNXB	ENST00000375247	human	ensembl	74_37	-1	known	missense	c.8320	p.D2774N	0.925	pfam_Fibronectin_type3,superfamily_Fibronectin_type3,smart_Fibronectin_type3,pfscan_Fibronectin_type3	pfam_Fibronectin_type3,pfam_Fibrinogen_a/b/g_C_dom,pfam_EGF_extracell,superfamily_Fibrinogen_a/b/g_C_dom,superfamily_Fibronectin_type3,smart_EG-like_dom,smart_Fibronectin_type3,smart_Fibrinogen_a/b/g_C_dom,pfscan_EG-like_dom,pfscan_Fibronectin_type3	-	no_errors	TNXB	HGNC	ENSG00000168477	tier1	-	-	55	0	0.00	42	67	61.47	19	0	0.00	5	2	28.57
CTPS2	0	genome.wustl.edu	37	X	16609019	16609020	+	R	INS	-	-	A			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	-	-	-	A	-	-	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	X	16609019	16609020	-	A	INS	CTPS2	ENST00000483053	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.000:0.000	-	-	-	no_errors	CTPS2	HGNC	ENSG00000047230	tier1			25	0	0.00	22	3	12.00	135	1	0.74	121	9	6.92
HSPG2	0	genome.wustl.edu	37	1	22149775	22149775	+	R	SNP	G	G	A			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	1	22149775	22149775	G	A	SNP	HSPG2	ENST00000486901	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.001	-	-	-	no_errors	HSPG2	HGNC	ENSG00000142798	tier1	-	-	26	0	0.00	38	5	11.63	8	0	0.00	6	0	0.00
KRTAP5-5	0	genome.wustl.edu	37	11	1651597	1651597	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	11	1651597	1651597	C	T	SNP	KRTAP5-5	ENST00000399676	human	ensembl	74_37	+1	known	missense	c.527	p.S176F	0.192	NULL	NULL	-	no_errors	KRTAP5-5	HGNC	ENSG00000185940	tier1	-	-	116	0	0.00	95	22	18.80	5	0	0.00	3	1	25.00
SKIDA1	0	genome.wustl.edu	37	10	21805720	21805720	+	Silent	SNP	A	A	G			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	10	21805720	21805720	A	G	SNP	SKIDA1	ENST00000449193	human	ensembl	74_37	-1	known	silent	c.1032	p.H344	0.972	NULL	pfam_Transform_Ski,superfamily_D-bd_dom_put	-	no_errors	SKIDA1	HGNC	ENSG00000180592	tier1	-	-	32	0	0.00	63	6	8.70	10	0	0.00	7	0	0.00
CENPB	0	genome.wustl.edu	37	20	3767122	3767184	+	In_Frame_Del	DEL	GGGGCCCATCCCGGCGCGCCCCCCGCCCCGGGGCCCGGCGCCGCCGCCGCCGCCCCGGGGCGG	GGGGCCCATCCCGGCGCGCCCCCCGCCCCGGGGCCCGGCGCCGCCGCCGCCGCCCCGGGGCGG	-			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	GGGGCCCATCCCGGCGCGCCCCCCGCCCCGGGGCCCGGCGCCGCCGCCGCCGCCCCGGGGCGG	GGGGCCCATCCCGGCGCGCCCCCCGCCCCGGGGCCCGGCGCCGCCGCCGCCGCCCCGGGGCGG					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	20	3767122	3767184	GGGGCCCATCCCGGCGCGCCCCCCGCCCCGGGGCCCGGCGCCGCCGCCGCCGCCCCGGGGCGG	-	DEL	CENPB	ENST00000379751	human	ensembl	74_37	-1	known	in_frame_del	c.9_1	p.MGP1in_frame_del	1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000	superfamily_Homeodomain-like,pfscan_HTH_Psq	pfam_Centromere_CenpB_dimerisation,pfam_DDE_SF_endonuclease_CENPB-like,pfam_HTH_Psq,pfam_HTH_CenpB_D-bd_dom,superfamily_Homeodomain-like,smart_HTH_CenpB_D-bd_dom,pfscan_HTH_Psq	-	no_errors	CENPB	HGNC	ENSG00000125817	tier1			0	0	0.00	0	0	0.00	0	0	0.00	0	0	0.00
DNM1P34	0	genome.wustl.edu	37	15	75592881	75592908	+	R	DEL	CGGGCTTCCCTCTTCTCTGGTCACCCTC	CGGGCTTCCCTCTTCTCTGGTCACCCTC	-			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	CGGGCTTCCCTCTTCTCTGGTCACCCTC	CGGGCTTCCCTCTTCTCTGGTCACCCTC					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	15	75592881	75592908	CGGGCTTCCCTCTTCTCTGGTCACCCTC	-	DEL	DNM1P34	ENST00000567292	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.000:0.001:0.002:0.003:0.016:0.019:0.542:0.707:0.754:0.765:0.759:0.735:0.645:0.577:0.391:0.379:0.371:0.364:0.334:0.225:0.038:0.019:0.014:0.015:0.015:0.021:0.029:0.030	-	-	-	no_errors	DNM1P34	HGNC	ENSG00000260357	tier1			0	0	0.00	0	1	100.00	0	0	0.00	0	1	100.00
FAM120C	0	genome.wustl.edu	37	X	54209302	54209303	+	In_Frame_Ins	INS	-	-	GGCGGC			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	-	-					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	X	54209302	54209303	-	GGCGGC	INS	FAM120C	ENST00000375180	human	ensembl	74_37	-1	known	in_frame_ins	c.330_329	p.112in_frame_insPP	0.999:0.998	NULL	NULL	-	no_errors	FAM120C	HGNC	ENSG00000184083	tier1			0	0	0.00	2	0	0.00	0	0	0.00	2	0	0.00
GOLGA8N	0	genome.wustl.edu	37	15	32890118	32890118	+	Silent	SNP	A	A	G			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	15	32890118	32890118	A	G	SNP	GOLGA8N	ENST00000448387	human	ensembl	74_37	+1	known	silent	c.426	p.K142	0.187	NULL	NULL	-	no_errors	GOLGA8N	HGNC	ENSG00000232653	tier1	-	-	52	0	0.00	65	29	30.85	0	0	0.00	0	0	0.00
ID4	0	genome.wustl.edu	37	6	19838106	19838108	+	In_Frame_Del	DEL	GCG	GCG	-			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	GCG	GCG					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	6	19838106	19838108	GCG	-	DEL	ID4	ENST00000378700	human	ensembl	74_37	+1	known	in_frame_del	c.121_123	p.A44in_frame_del	0.988:0.989:0.984	superfamily_Trp_syn_b_sub_like_PLP_eny_SF	pfam_bHLH_dom,superfamily_bHLH_dom,superfamily_Trp_syn_b_sub_like_PLP_eny_SF,smart_bHLH_dom,pfscan_bHLH_dom	-	no_errors	ID4	HGNC	ENSG00000172201	tier1			13	0	0.00	22	4	15.38	0	0	0.00	0	0	0.00
MLC1	0	genome.wustl.edu	37	22	50502469	50502470	+	In_Frame_Ins	INS	-	-	GCACCCCCACCCCACAGGCCACTCACCTCCCCG			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	-	-					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	22	50502469	50502470	-	GCACCCCCACCCCACAGGCCACTCACCTCCCCG	INS	MLC1	ENST00000311597	human	ensembl	74_37	-1	known	in_frame_ins	c.1053_1052	p.355in_frame_insSGLWGGGAGEV	0.000:0.000	NULL	NULL	-	no_errors	MLC1	HGNC	ENSG00000100427	tier1			0	0	0.00	0	0	0.00	0	0	0.00	0	0	0.00
TBC1D10B	0	genome.wustl.edu	37	16	30381257	30381268	+	In_Frame_Del	DEL	GCCGGGGCTGGG	GCCGGGGCTGGG	-			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	GCCGGGGCTGGG	GCCGGGGCTGGG					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	16	30381257	30381268	GCCGGGGCTGGG	-	DEL	TBC1D10B	ENST00000409939	human	ensembl	74_37	-1	known	in_frame_del	c.248_237	p.PAPA80in_frame_del	0.000:0.000:0.000:0.001:0.000:0.000:0.000:0.000:0.000:0.000:0.000:0.001	NULL	pfam_Rab-GTPase-TBC_dom,superfamily_Rab-GTPase-TBC_dom,smart_Rab-GTPase-TBC_dom,pfscan_Rab-GTPase-TBC_dom	-	no_errors	TBC1D10B	HGNC	ENSG00000169221	tier1			0	0	0.00	0	0	0.00	0	0	0.00	0	0	0.00
KRTAP5-5	0	genome.wustl.edu	37	11	1651627	1651627	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	11	1651627	1651627	C	T	SNP	KRTAP5-5	ENST00000399676	human	ensembl	74_37	+1	known	missense	c.557	p.S186F	0.931	NULL	NULL	-	no_errors	KRTAP5-5	HGNC	ENSG00000185940	tier1	-	-	101	0	0.00	102	10	8.93	2	0	0.00	5	2	28.57
TCP11	0	genome.wustl.edu	37	6	35109033	35109040	+	R	DEL	GCGGCCTG	GCGGCCTG	-			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	GCGGCCTG	GCGGCCTG					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	6	35109033	35109040	GCGGCCTG	-	DEL	TCP11	ENST00000394696	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.001:0.000:0.000:0.001:0.002:0.001:0.000:0.000	-	-	-	no_errors	TCP11	HGNC	ENSG00000124678	tier1			0	0	0.00	0	2	100.00	0	0	0.00	0	2	100.00
P2RX2	0	genome.wustl.edu	37	12	133197922	133197922	+	Silent	SNP	G	G	A			TCGA-DX-A8BN-01A-11D-A37C-09	TCGA-DX-A8BN-11A-22D-A37F-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	0238c3ff-c720-4350-b0e8-5b4823f91075	87bd9e83-45b1-430d-b7ef-bb83264ebbb3	12	133197922	133197922	G	A	SNP	P2RX2	ENST00000343948	human	ensembl	74_37	+1	known	silent	c.987	p.V329	1.000	pfam_P2X_purnocptor,prints_P2X_purnocptor,tigrfam_P2X_purnocptor	pfam_P2X_purnocptor,prints_P2X2_purnocptor,prints_P2X_purnocptor,tigrfam_P2X_purnocptor	-	no_errors	P2RX2	HGNC	ENSG00000187848	tier1	-	-	30	0	0.00	18	5	21.74	54	0	0.00	57	2	3.39