Hugo_Symbol Entrez_Gene_Id Center NCBI_Build Chromosome Start_position End_position Strand Variant_Classification Variant_Type Reference_Allele Tumor_Seq_Allele1 Tumor_Seq_Allele2 dbSNP_RS dbSNP_Val_Status Tumor_Sample_Barcode Matched_Norm_Sample_Barcode Match_Norm_Seq_Allele1 Match_Norm_Seq_Allele2 Tumor_Validation_Allele1 Tumor_Validation_Allele2 Match_Norm_Validation_Allele1 Match_Norm_Validation_Allele2 Verification_Status Validation_Status Mutation_Status Sequencing_Phase Sequence_Source Validation_Method Score BAM_file Sequencer Tumor_Sample_UUID Matched_Norm_Sample_UUID Genome_Change Annotation_Transcript Transcript_Strand Transcript_Exon Transcript_Position cDNA_Change Codon_Change Protein_Change Other_Transcripts Refseq_mRNA_Id Refseq_prot_Id SwissProt_acc_Id SwissProt_entry_Id Description UniProt_AApos UniProt_Region UniProt_Site UniProt_Natural_Variations UniProt_Experimental_Info GO_Biological_Process GO_Cellular_Component GO_Molecular_Function COSMIC_overlapping_mutations COSMIC_fusion_genes COSMIC_tissue_types_affected COSMIC_total_alterations_in_gene Tumorscape_Amplification_Peaks Tumorscape_Deletion_Peaks TCGAscape_Amplification_Peaks TCGAscape_Deletion_Peaks DrugBank ref_context gc_content CCLE_ONCOMAP_overlapping_mutations CCLE_ONCOMAP_total_mutations_in_gene CGC_Mutation_Type CGC_Translocation_Partner CGC_Tumor_Types_Somatic CGC_Tumor_Types_Germline CGC_Other_Diseases DNARepairGenes_Role FamilialCancerDatabase_Syndromes MUTSIG_Published_Results OREGANNO_ID OREGANNO_Values t_alt_count t_ref_count validation_alt_allele validation_method validation_status validation_tumor_sample HIST2H2BA 337875 broad.mit.edu 37 1 120906148 120906148 + RNA SNP G G T TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr1:120906148G>T ENST00000430394.1 + 0 121 NR_027337.1 CAGCCGCAAGGAGAGCTACTC 0.582 73 79 --- --- --- --- SELE 6401 broad.mit.edu 37 1 169696555 169696555 + Missense_Mutation SNP T T C TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr1:169696555T>C ENST00000333360.7 - 10 1719 c.1580A>G c.(1579-1581)aAt>aGt p.N527S SELE_ENST00000367782.4_Missense_Mutation_p.N464S|SELE_ENST00000367774.1_Missense_Mutation_p.N401S|SELE_ENST00000367779.4_Missense_Mutation_p.N401S|SELE_ENST00000367775.1_Missense_Mutation_p.N402S|SELE_ENST00000367776.1_Missense_Mutation_p.N464S|C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367781.4_Missense_Mutation_p.N464S|SELE_ENST00000367780.4_Missense_Mutation_p.N402S|SELE_ENST00000367777.1_Missense_Mutation_p.N464S NM_000450.2 NP_000441.2 P16581 LYAM2_HUMAN selectin E 527 Sushi 6. actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1) 32 all_hematologic(923;0.208) TGCAGAGCCATTGAGCGTCCA 0.552 6 69 --- --- --- --- PXDN 7837 broad.mit.edu 37 2 1677528 1677528 + Missense_Mutation SNP A A G TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr2:1677528A>G ENST00000252804.4 - 9 955 c.905T>C c.(904-906)cTg>cCg p.L302P PXDN_ENST00000483018.1_5'UTR NM_012293.1 NP_036425.1 Q92626 PXDN_HUMAN peroxidasin homolog (Drosophila) 302 Ig-like C2-type 1. extracellular matrix organization|hydrogen peroxide catabolic process|immune response endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3) 112 Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797) all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716) all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228) CTGGATCATCAGGGTCCCATC 0.502 3 137 --- --- --- --- C2orf42 54980 broad.mit.edu 37 2 70408850 70408850 + Missense_Mutation SNP C C T TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr2:70408850C>T ENST00000264434.2 - 3 647 c.268G>A c.(268-270)Gtg>Atg p.V90M C2orf42_ENST00000420306.1_Missense_Mutation_p.V90M|C2orf42_ENST00000470096.1_5'UTR NM_017880.1 NP_060350.1 Q9NWW7 CB042_HUMAN chromosome 2 open reading frame 42 90 endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(1) 12 CCGAGCTCCACAAAGCATCGG 0.522 8 75 --- --- --- --- TNS1 7145 broad.mit.edu 37 2 218673380 218673380 + Missense_Mutation SNP C C T TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr2:218673380C>T ENST00000171887.4 - 31 5428 c.4976G>A c.(4975-4977)cGc>cAc p.R1659H TNS1_ENST00000430930.1_Missense_Mutation_p.R1638H|TNS1_ENST00000419504.1_Missense_Mutation_p.R1645H NM_022648.4 NP_072174.3 Q9HBL0 TENS1_HUMAN tensin 1 1659 cytoplasm|cytoskeleton|focal adhesion actin binding breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1) 79 Renal(207;0.0483)|Lung NSC(271;0.213) Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013) AGGGTAGTGGCGTCTGAAAAA 0.502 21 105 --- --- --- --- IL7R 3575 broad.mit.edu 37 5 35871289 35871289 + Missense_Mutation SNP C C A TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr5:35871289C>A ENST00000303115.3 + 4 640 c.511C>A c.(511-513)Cag>Aag p.Q171K IL7R_ENST00000343305.4_Missense_Mutation_p.Q171K|IL7R_ENST00000506850.1_Missense_Mutation_p.Q171K NM_002185.3 NP_002176.2 P16871 IL7RA_HUMAN interleukin 7 receptor 171 Fibronectin type-III. immune response|regulation of DNA recombination extracellular region|integral to membrane antigen binding|interleukin-7 receptor activity NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3) 126 all_lung(31;0.00015) Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202) AGCTTACCGCCAGGAAAAGGA 0.348 """Mis, O""" """ALL, ETP ALL""" Severe combined immune deficiency 5 44 --- --- --- --- EFNA5 1946 broad.mit.edu 37 5 106723460 106723460 + Missense_Mutation SNP G G A TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr5:106723460G>A ENST00000333274.6 - 3 712 c.431C>T c.(430-432)cCa>cTa p.P144L EFNA5_ENST00000510359.1_5'UTR|EFNA5_ENST00000509503.1_Missense_Mutation_p.P144L NM_001962.2 NP_001953.1 P52803 EFNA5_HUMAN ephrin-A5 144 cell-cell signaling anchored to plasma membrane|caveola|extracellular space ephrin receptor binding large_intestine(6) 6 all_cancers(142;5.15e-06)|all_epithelial(76;4.39e-07)|Prostate(80;0.00726)|Lung NSC(167;0.0736)|Ovarian(225;0.0797)|all_lung(232;0.0854)|Colorectal(57;0.241) Epithelial(69;1.25e-12)|OV - Ovarian serous cystadenocarcinoma(64;1.32e-11)|BRCA - Breast invasive adenocarcinoma(61;0.0376)|COAD - Colon adenocarcinoma(37;0.109) TCCATTATCTGGGATTGCAGA 0.423 15 80 --- --- --- --- TBCC 6903 broad.mit.edu 37 6 42713803 42713803 + Silent SNP G G A TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr6:42713803G>A ENST00000244625.2 - 2 572 c.9C>T c.(7-9)tcC>tcT p.S3S TBCC_ENST00000372876.1_Silent_p.S3S Q15814 TBCC_HUMAN tubulin folding cofactor C 3 'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway cytoplasm|microtubule|photoreceptor connecting cilium chaperone binding|GTPase activity p.S3S(1) breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(3) 14 Colorectal(47;0.196) all cancers(41;0.00122)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.125) AGCAACTGACGGACTCCATAT 0.617 19 44 --- --- --- --- GCM1 8521 broad.mit.edu 37 6 53010374 53010374 + Silent SNP A A G TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr6:53010374A>G ENST00000259803.7 - 2 268 c.57T>C c.(55-57)aaT>aaC p.N19N NM_003643.3 NP_003634.2 Q9NP62 GCM1_HUMAN glial cells missing homolog 1 (Drosophila) 19 transcription factor complex DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|skin(1) 24 Lung NSC(77;0.0755) GTTTCACATCATTAATATCCC 0.423 3 112 --- --- --- --- NEUROD6 63974 broad.mit.edu 37 7 31378577 31378577 + Silent SNP G G A TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr7:31378577G>A ENST00000297142.3 - 2 628 c.306C>T c.(304-306)cgC>cgT p.R102R NM_022728.2 NP_073565.2 Q96NK8 NDF6_HUMAN neuronal differentiation 6 102 cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent nucleus DNA binding breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1) 32 TGTTCCTCTCGCGCGCGTTCG 0.473 14 137 --- --- --- --- ABCA13 154664 broad.mit.edu 37 7 48266917 48266917 + Missense_Mutation SNP C C T TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr7:48266917C>T ENST00000435803.1 + 6 551 c.527C>T c.(526-528)cCt>cTt p.P176L NM_152701.3 NP_689914.2 Q86UQ4 ABCAD_HUMAN ATP-binding cassette, sub-family A (ABC1), member 13 176 transport integral to membrane ATP binding|ATPase activity breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4) 270 CATCAGCAGCCTCATATCTGG 0.433 14 103 --- --- --- --- PRDM14 63978 broad.mit.edu 37 8 70981761 70981761 + Missense_Mutation SNP G G A TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr8:70981761G>A ENST00000276594.2 - 2 536 c.335C>T c.(334-336)cCg>cTg p.P112L NM_024504.3 NP_078780.1 Q9GZV8 PRD14_HUMAN PR domain containing 14 112 regulation of transcription, DNA-dependent|transcription, DNA-dependent nucleus DNA binding|zinc ion binding NS(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1) 32 Breast(64;0.193) Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405) CAGGAAGGGCGGCACTTCCCT 0.627 11 8 --- --- --- --- A1CF 29974 broad.mit.edu 37 10 52595833 52595833 + Splice_Site SNP C C A TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr10:52595833C>A ENST00000374001.2 - 5 744 c.e5+1 A1CF_ENST00000373993.1_Splice_Site|A1CF_ENST00000395489.2_Splice_Site|A1CF_ENST00000395495.1_Splice_Site|A1CF_ENST00000373997.3_Splice_Site|A1CF_ENST00000373995.3_Splice_Site|A1CF_ENST00000282641.2_Splice_Site Q9NQ94 A1CF_HUMAN APOBEC1 complementation factor cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm nucleotide binding|protein binding|single-stranded RNA binding NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3) 29 GGATTGCTAACCTGGTAGCAG 0.463 29 49 --- --- --- --- MKI67 4288 broad.mit.edu 37 10 129905901 129905901 + Silent SNP C C T TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr10:129905901C>T ENST00000368654.3 - 13 4578 c.4203G>A c.(4201-4203)caG>caA p.Q1401Q MKI67_ENST00000368653.3_Silent_p.Q1041Q NM_002417.4 NP_002408.3 P46013 KI67_HUMAN marker of proliferation Ki-67 1401 16 X 122 AA approximate repeats. cell proliferation nucleolus ATP binding|protein C-terminus binding NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4) 159 all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203) AGAGCTCCTTCTGTACGTCCC 0.493 4 205 --- --- --- --- OR51G1 79324 broad.mit.edu 37 11 4945119 4945119 + Missense_Mutation SNP C C A TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr11:4945119C>A ENST00000321961.2 - 1 518 c.451G>T c.(451-453)Gtg>Ttg p.V151L MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron NM_001005237.1 NP_001005237.1 Q8NGK1 O51G1_HUMAN olfactory receptor, family 51, subfamily G, member 1 151 sensory perception of smell integral to membrane|plasma membrane olfactory receptor activity NS(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(3)|skin(4)|soft_tissue(1) 25 Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086) Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19) CTTCTAAGCACTGAGCTTAGC 0.532 34 35 --- --- --- --- AHNAK 79026 broad.mit.edu 37 11 62289690 62289690 + Nonsense_Mutation SNP T T A TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr11:62289690T>A ENST00000378024.4 - 5 12473 c.12199A>T c.(12199-12201)Aaa>Taa p.K4067* AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron NM_001620.1 NP_001611.1 Q09666 AHNK_HUMAN AHNAK nucleoprotein 4067 nervous system development nucleus protein binding NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6) 268 Melanoma(852;0.155) ATGCTGAATTTGGGCATTTTC 0.493 31 265 --- --- --- --- OR6C76 390326 broad.mit.edu 37 12 55820867 55820867 + Missense_Mutation SNP C C G TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr12:55820867C>G ENST00000328314.3 + 1 830 c.830C>G c.(829-831)tCt>tGt p.S277C NM_001005183.1 NP_001005183.1 A6NM76 O6C76_HUMAN olfactory receptor, family 6, subfamily C, member 76 277 sensory perception of smell integral to membrane|plasma membrane olfactory receptor activity NS(1)|central_nervous_system(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1) 14 CTCAATACCTCTGTCGCTCCT 0.378 22 29 --- --- --- --- MYF5 4617 broad.mit.edu 37 12 81110950 81110950 + Silent SNP G G T TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr12:81110950G>T ENST00000228644.3 + 1 260 c.108G>T c.(106-108)gtG>gtT p.V36V NM_005593.2 NP_005584.2 P13349 MYF5_HUMAN myogenic factor 5 36 muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development nucleoplasm DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(8)|lung(15)|ovary(2)|pancreas(1) 30 TGCCGCGAGTGGCTGCCTTCG 0.612 10 13 --- --- --- --- HNF1A 6927 broad.mit.edu 37 12 121434123 121434123 + Silent SNP C C T TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr12:121434123C>T ENST00000257555.6 + 5 1240 c.1014C>T c.(1012-1014)ggC>ggT p.G338G HNF1A_ENST00000543427.1_Silent_p.G221G|HNF1A_ENST00000544413.1_Silent_p.G338G|HNF1A_ENST00000538626.1_Intron|HNF1A_ENST00000402929.1_Silent_p.G338G|HNF1A_ENST00000400024.2_Silent_p.G338G|HNF1A_ENST00000541395.1_Silent_p.G338G P20823 HNF1A_HUMAN HNF1 homeobox A 338 glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption cytoplasm|nucleus|protein complex DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding breast(3)|central_nervous_system(2)|cervix(1)|endometrium(8)|large_intestine(19)|liver(175)|lung(9)|ovary(2)|prostate(1)|urinary_tract(1) 221 all_neural(191;0.0684)|Medulloblastoma(191;0.0922) CAAGCAGCGGCGGTCCCTTAG 0.622 Hepatic Adenoma, Familial Clustering of 29 118 --- --- --- --- ATP6V0A2 23545 broad.mit.edu 37 12 124241431 124241431 + Missense_Mutation SNP T T G TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr12:124241431T>G ENST00000330342.3 + 19 2611 c.2363T>G c.(2362-2364)tTg>tGg p.L788W ATP6V0A2_ENST00000543687.1_3'UTR|ATP6V0A2_ENST00000544833.1_Missense_Mutation_p.L70W NM_012463.3 NP_036595.2 Q9Y487 VPP2_HUMAN ATPase, H+ transporting, lysosomal V0 subunit a2 788 ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|transferrin transport endosome membrane|integral to membrane|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain hydrogen ion transmembrane transporter activity|protein binding endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1) 26 all_neural(191;0.101)|Medulloblastoma(191;0.163) OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.000625)|all cancers(50;0.00775) TATGGCGTCTTGCTACTGCTC 0.552 9 127 --- --- --- --- JPH4 84502 broad.mit.edu 37 14 24040359 24040359 + Silent SNP G G A TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr14:24040359G>A ENST00000397118.3 - 6 2483 c.1581C>T c.(1579-1581)gaC>gaT p.D527D JPH4_ENST00000356300.4_Silent_p.D527D|JPH4_ENST00000544177.1_Silent_p.D192D NM_032452.2 NP_115828.2 Q96JJ6 JPH4_HUMAN junctophilin 4 527 calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity integral to membrane|junctional sarcoplasmic reticulum membrane endometrium(1)|large_intestine(2)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1) 22 all_cancers(95;0.000251) GBM - Glioblastoma multiforme(265;0.00654) GTGGGGAACCGTCTCTGGGCC 0.667 72 173 --- --- --- --- SAV1 60485 broad.mit.edu 37 14 51132328 51132328 + Missense_Mutation SNP G G A TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr14:51132328G>A ENST00000324679.4 - 2 467 c.104C>T c.(103-105)cCt>cTt p.P35L NM_021818.3 NP_068590.1 Q9H4B6 SAV1_HUMAN salvador homolog 1 (Drosophila) 35 hippo signaling cascade cytoplasm|nucleus identical protein binding breast(1)|kidney(2)|lung(2)|prostate(1) 6 all_epithelial(31;0.000611)|Breast(41;0.0333) GATGAATGAAGGCATAAGATC 0.358 5 16 --- --- --- --- DNM1P34 729809 broad.mit.edu 37 15 75594869 75594869 + RNA SNP C C T TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr15:75594869C>T ENST00000567292.1 - 0 437 CATGAGGTCCCACACGGTCTT 0.587 5 35 --- --- --- --- KIAA1024 23251 broad.mit.edu 37 15 79748639 79748639 + Silent SNP C C G TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr15:79748639C>G ENST00000305428.3 + 2 225 c.150C>G c.(148-150)ctC>ctG p.L50L NM_015206.2 NP_056021.1 Q9UPX6 K1024_HUMAN KIAA1024 50 integral to membrane central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(2)|pancreas(2)|prostate(1) 49 GAAGTGTGCTCTTCTACACAG 0.458 49 60 --- --- --- --- DYNC1LI2 1783 broad.mit.edu 37 16 66770148 66770148 + Splice_Site SNP C C T TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr16:66770148C>T ENST00000258198.2 - 5 736 c.e5-1 DYNC1LI2_ENST00000440564.2_Splice_Site|DYNC1LI2_ENST00000443351.2_Splice_Site|DYNC1LI2_ENST00000379482.2_Splice_Site NM_006141.2 NP_006132.1 O43237 DC1L2_HUMAN dynein, cytoplasmic 1, light intermediate chain 2 transport centrosome|cytoplasmic dynein complex|microtubule ATP binding|motor activity central_nervous_system(3)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|skin(4)|stomach(1) 15 Ovarian(137;0.0563) OV - Ovarian serous cystadenocarcinoma(108;0.0907)|Epithelial(162;0.212) TCTTTCACAACTGGGGGAAAA 0.393 17 4 --- --- --- --- OR3A2 4995 broad.mit.edu 37 17 3181633 3181633 + Silent SNP G G A TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr17:3181633G>A ENST00000408891.2 - 1 635 c.597C>T c.(595-597)tcC>tcT p.S199S NM_002551.3 NP_002542.3 P47893 OR3A2_HUMAN olfactory receptor, family 3, subfamily A, member 2 199 sensory perception of smell integral to plasma membrane olfactory receptor activity ovary(1) 1 GTTGGGTGCTGGAGCAGGAGA 0.552 21 68 --- --- --- --- TP53 7157 broad.mit.edu 37 17 7577566 7577566 + Missense_Mutation SNP T T C TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr17:7577566T>C ENST00000420246.2 - 7 847 c.715A>G c.(715-717)Aac>Gac p.N239D TP53_ENST00000413465.2_Missense_Mutation_p.N239D|TP53_ENST00000455263.2_Missense_Mutation_p.N239D|TP53_ENST00000445888.2_Missense_Mutation_p.N239D|TP53_ENST00000269305.4_Missense_Mutation_p.N239D|TP53_ENST00000359597.4_Missense_Mutation_p.N239D NM_001126114.2|NM_001276696.1 NP_001119586.1|NP_001263625.1 P04637 P53_HUMAN tumor protein p53 239 Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity). N -> D (in sporadic cancers; somatic mutation).|N -> H (in a sporadic cancer; somatic mutation).|N -> I (in a sporadic cancer; somatic mutation).|N -> K (in sporadic cancers; somatic mutation).|N -> S (in sporadic cancers; somatic mutation).|N -> T (in sporadic cancers; somatic mutation).|N -> Y (in sporadic cancers; somatic mutation). activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding p.N239D(33)|p.N239fs*25(12)|p.0?(8)|p.N239Y(6)|p.N239fs*1(5)|p.?(5)|p.M237_N239delMCN(4)|p.N239_C242delNSSC(3)|p.N239fs*8(2)|p.N239_S240delNS(2)|p.N239fs*26(1)|p.N146D(1)|p.N146fs*1(1)|p.Y236_M243delYMCNSSCM(1)|p.V225fs*23(1)|p.N239fs*6(1)|p.N239fs*4(1)|p.C238_N239insX(1)|p.C238_M246delCNSSCMGGM(1)|p.M144_N146delMCN(1)|p.C238fs*21(1)|p.H233fs*6(1)|p.N239*(1)|p.H233_C242del10(1)|p.N239_C242del(1) NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79) 24185 all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081) GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174) CAGGAACTGTTACACATGTAG 0.572 111 """Mis, N, F""" """breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types""" """breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types""" Other conserved DNA damage response genes Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019) 37 43 --- --- --- --- KCNJ12 3768 broad.mit.edu 37 17 21319343 21319343 + Missense_Mutation SNP C C T TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr17:21319343C>T ENST00000583088.1 + 3 1584 c.689C>T c.(688-690)gCg>gTg p.A230V KCNJ12_ENST00000331718.5_Missense_Mutation_p.A230V NM_021012.4 NP_066292.2 potassium inwardly-rectifying channel, subfamily J, member 12 NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3) 70 Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732) CATGTGCGCGCGCAGCTCATC 0.637 Prostate(3;0.18) 4 64 --- --- --- --- C17orf78 284099 broad.mit.edu 37 17 35745662 35745662 + Missense_Mutation SNP T T A TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr17:35745662T>A ENST00000300618.4 + 5 616 c.566T>A c.(565-567)aTt>aAt p.I189N ACACA_ENST00000353139.5_Intron|ACACA_ENST00000416895.1_Intron|C17orf78_ENST00000586700.1_Intron|ACACA_ENST00000589665.1_Intron NM_173625.3 NP_775896.3 Q8N4C9 CQ078_HUMAN chromosome 17 open reading frame 78 189 integral to membrane NS(1)|endometrium(1)|large_intestine(1)|lung(2)|stomach(1) 6 Breast(25;0.00295)|Ovarian(249;0.15) AAAATTCTGATTGCTGTCACC 0.398 13 12 --- --- --- --- CDH2 1000 broad.mit.edu 37 18 25583091 25583091 + Missense_Mutation SNP G G T TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr18:25583091G>T ENST00000269141.3 - 7 1313 c.890C>A c.(889-891)cCc>cAc p.P297H CDH2_ENST00000399380.3_Missense_Mutation_p.P266H NM_001792.3 NP_001783.2 P19022 CADH2_HUMAN cadherin 2, type 1, N-cadherin (neuronal) 297 Cadherin 2. adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation catenin complex|integral to membrane alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1) 82 GAGGGCATTGGGATCGTCAGC 0.458 4 84 --- --- --- --- SHC2 25759 broad.mit.edu 37 19 438989 438989 + Missense_Mutation SNP C C T TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr19:438989C>T ENST00000264554.6 - 3 580 c.581G>A c.(580-582)cGg>cAg p.R194Q NM_012435.2 NP_036567.2 P98077 SHC2_HUMAN SHC (Src homology 2 domain containing) transforming protein 2 194 PID. insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction cytosol endometrium(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(1) 21 all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228) UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18) CCAGGATCCCCGGACGCCAGG 0.677 9 12 --- --- --- --- PRKACA 5566 broad.mit.edu 37 19 14204548 14204548 + Silent SNP C C A TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr19:14204548C>A ENST00000308677.4 - 9 1018 c.822G>T c.(820-822)ctG>ctT p.L274L PRKACA_ENST00000350356.3_5'UTR|PRKACA_ENST00000590853.1_Intron|PRKACA_ENST00000589994.1_Silent_p.L266L NM_002730.3 NP_002721.1 P17612 KAPCA_HUMAN protein kinase, cAMP-dependent, catalytic, alpha 274 Protein kinase. activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|regulation of insulin secretion|transmembrane transport|triglyceride catabolic process|water transport cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane ATP binding|cAMP-dependent protein kinase activity|cAMP-dependent protein kinase inhibitor activity|protein kinase binding central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1) 16 GATCTACCTGCAGGAGGTTCC 0.542 3 66 --- --- --- --- RAC2 5880 broad.mit.edu 37 22 37622732 37622732 + Missense_Mutation SNP C C T TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chr22:37622732C>T ENST00000249071.6 - 6 681 c.560G>A c.(559-561)cGc>cAc p.R187H RAC2_ENST00000406508.1_Missense_Mutation_p.R143H|RAC2_ENST00000405484.1_Missense_Mutation_p.R180H NM_002872.3 NP_002863.1 P15153 RAC2_HUMAN ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 187 axon guidance|platelet activation|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction cytosol|plasma membrane GTP binding|GTPase activity|protein binding breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(2)|upper_aerodigestive_tract(1) 12 GCTGCAGGCGCGCTTCTGCTG 0.632 7 15 --- --- --- --- NSDHL 50814 broad.mit.edu 37 X 152037459 152037459 + Silent SNP A A G TCGA-HI-7171-01A-12D-2114-08 TCGA-HI-7171-10A-01D-2115-08 Untested Somatic Phase_I WXS none Illumina GAIIx 880022c4-45e7-4c49-92a2-231924b36310 d26a95e2-53bc-4bf8-8b58-3fe3899d106e g.chrX:152037459A>G ENST00000370274.3 + 8 1115 c.921A>G c.(919-921)ctA>ctG p.L307L NSDHL_ENST00000440023.1_Silent_p.L307L NM_015922.2 NP_057006.1 Q15738 NSDHL_HUMAN NAD(P) dependent steroid dehydrogenase-like 307 cholesterol biosynthetic process endoplasmic reticulum membrane|integral to membrane 3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity|sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity NS(1)|breast(1)|cervix(1)|endometrium(4)|large_intestine(3)|lung(5) 15 Acute lymphoblastic leukemia(192;6.56e-05) NADH(DB00157) CCCTCCTGCTATCCCTGCTGG 0.582 38 5 --- --- --- ---