Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FAM83D	81610	broad.mit.edu	37	20	37580459	37580459	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr20:37580459G>A	ENST00000217429.4	+	4	1185	c.1144G>A	c.(1144-1146)Gca>Aca	p.A382T		NM_030919.2	NP_112181.2	Q9H4H8	FA83D_HUMAN	family with sequence similarity 83, member D	352					cell division|mitosis	cytoplasm|spindle pole				endometrium(2)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)|stomach(1)	28		Myeloproliferative disorder(115;0.00878)				AGAGATGCCCGCAGAGGGCAA	0.602000													3	37					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14536429	14536429	+	RNA	SNP	T	T	C			TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr3:14536429T>C	ENST00000273083.3	-	0	2956							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						CATAGACACCTTTTTCCAGGA	0.612000													3	60					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	A	G	rs9424867		TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr1:145302714A>G	ENST00000342960.5	+	8	1187	c.1152A>G	c.(1150-1152)ttA>ttG	p.L384L	RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369338.1_Silent_p.L113L|NBPF10_ENST00000369339.2_Silent_p.L113L	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	384								p.L113L(3)|p.L384L(3)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527000													5	43					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533874	533874	+	Missense_Mutation	SNP	T	T	C	rs121913233		TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr11:533874T>C	ENST00000417302.1	-	3	369	c.182A>G	c.(181-183)cAg>cGg	p.Q61R	HRAS_ENST00000311189.7_Missense_Mutation_p.Q61R|HRAS_ENST00000468682.2_5'UTR|HRAS_ENST00000451590.1_Missense_Mutation_p.Q61R|HRAS_ENST00000397594.1_Missense_Mutation_p.Q61R|HRAS_ENST00000397596.2_Missense_Mutation_p.Q61R	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	61			Q -> K (in follicular thyroid carcinoma samples; somatic mutation; increases transformation of cultured cell lines; dbSNP:rs28933406).|Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(136)|p.Q61L(117)|p.Q61P(3)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597000	Q61L(KNS62_LUNG)|Q61L(KYSE30_OESOPHAGUS)|Q61L(NCIH1915_LUNG)	6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			21	35					0	0	1	0	0
CXXC4	80319	broad.mit.edu	37	4	105412355	105412355	+	Missense_Mutation	SNP	G	G	C			TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr4:105412355G>C	ENST00000394767.2	-	2	1055	c.605C>G	c.(604-606)tCc>tGc	p.S202C	CXXC4_ENST00000466963.1_Intron|AC004053.1_ENST00000500179.1_RNA|CXXC4_ENST00000426831.1_Missense_Mutation_p.S33C	NM_025212.2	NP_079488.2	Q9H2H0	CXXC4_HUMAN	CXXC finger protein 4	33					negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway|zygotic specification of dorsal/ventral axis		DNA binding|PDZ domain binding|zinc ion binding			kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	11				OV - Ovarian serous cystadenocarcinoma(123;3.05e-08)		GTGTTCAGGGGATAAGGTGGA	0.562000													15	208					0	0	1	0	0
HERC2P3	283755	broad.mit.edu	37	15	20644024	20644024	+	RNA	SNP	G	G	A			TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr15:20644024G>A	ENST00000428453.1	-	0	3435																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						ACCGCCATGAGGCCCCCCACT	0.602000													13	19					0	0	1	0	0
RFWD3	55159	broad.mit.edu	37	16	74695298	74695298	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr16:74695298G>A	ENST00000361070.4	-	2	147	c.50C>T	c.(49-51)gCc>gTc	p.A17V	RFWD3_ENST00000571750.1_Missense_Mutation_p.A17V	NM_018124.3	NP_060594.3	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	17					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	26						CTGTTGTTCGGCATGATTTAA	0.478000													4	194					0	0	1	0	0
DUSP15	128853	broad.mit.edu	37	20	30436706	30436706	+	Splice_Site	SNP	C	C	A			TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr20:30436706C>A	ENST00000278979.3	-	9	705	c.628_splice	c.e9-1	p.G210_splice				Q9H1R2	DUS15_HUMAN	dual specificity phosphatase 15	210						cytoplasm|plasma membrane	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(1)|lung(4)|pancreas(1)|stomach(1)	7			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			CGGTGACCATCCTGCAGGTGG	0.577000													8	9					5.4927e-09	5.89957e-09	1	1	0
MLLT3	4300	broad.mit.edu	37	9	20414346	20414346	+	Silent	SNP	G	G	A			TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr9:20414346G>A	ENST00000380338.4	-	5	784	c.498C>T	c.(496-498)agC>agT	p.S166S	MLLT3_ENST00000429426.2_Silent_p.S163S|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	166	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S166S(4)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.527000			T	MLL	ALL								3	33					0	0	1	0	0
NUDT6	11162	broad.mit.edu	37	4	123843575	123843575	+	Silent	SNP	G	G	A			TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr4:123843575G>A	ENST00000304430.5	-	1	186	c.153C>T	c.(151-153)gaC>gaT	p.D51D	NUDT6_ENST00000339154.2_Intron	NM_007083.4	NP_009014.2	P53370	NUDT6_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 6	51						mitochondrion|nucleus	growth factor activity|hydrolase activity			endometrium(2)|lung(1)|prostate(1)|skin(1)|stomach(1)	6						CCCCGAATCTGTCCAGCTCGC	0.711000													3	15					0	0	1	0	0
UGT1A4	54657	broad.mit.edu	37	2	234627834	234627834	+	Missense_Mutation	SNP	C	C	T			TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr2:234627834C>T	ENST00000373409.3	+	1	411	c.368C>T	c.(367-369)gCc>gTc	p.A123V	UGT1A10_ENST00000373445.1_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A6_ENST00000305139.6_Intron	NM_007120.2	NP_009051.1														autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|skin(2)|urinary_tract(1)	26		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;3.49e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000504)|Lung(119;0.0026)|LUSC - Lung squamous cell carcinoma(224;0.00624)		GTATCTTTGGCCCTTCATAGG	0.443000													4	221					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713742	70713742	+	RNA	SNP	G	G	T	rs115439852	by1000genomes	TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr14:70713742G>T	ENST00000530196.1	-	0	776					NR_003951.1																						CCACAACAACGAGCTCCAGAA	0.433000													5	54					1.06961e-07	1.10781e-07	1	1	0
APBB1	322	broad.mit.edu	37	11	6422898	6422898	+	Missense_Mutation	SNP	C	C	T	rs139600801		TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr11:6422898C>T	ENST00000389906.2	-	9	1508	c.1409G>A	c.(1408-1410)cGt>cAt	p.R470H	APBB1_ENST00000533407.1_Missense_Mutation_p.R209H|APBB1_ENST00000530885.1_Missense_Mutation_p.R248H|APBB1_ENST00000524626.1_5'UTR|APBB1_ENST00000311051.3_Missense_Mutation_p.R468H|APBB1_ENST00000299402.6_Missense_Mutation_p.R468H	NM_001257325.1	NP_001244254.1	O00213	APBB1_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	470	PID 1.				apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|prostate(2)|skin(1)|urinary_tract(1)	24		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		CAGCTTATCACGAGCTACGTA	0.597000													3	48					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67677304	67677304	+	Missense_Mutation	SNP	C	C	T			TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr15:67677304C>T	ENST00000335894.4	+	11	1469	c.1403C>T	c.(1402-1404)gCc>gTc	p.A468V	IQCH_ENST00000360277.4_Missense_Mutation_p.A220V|IQCH_ENST00000358767.3_Missense_Mutation_p.A295V|IQCH_ENST00000546225.1_Missense_Mutation_p.A216V	NM_001031715.2	NP_001026885.1	Q86VS3	IQCH_HUMAN	IQ motif containing H	468										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		GAACATATTGCCGATTTCAAC	0.408000													4	170					0	0	1	0	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296167	39296167	+	Silent	SNP	A	A	G			TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr17:39296167A>G	ENST00000345847.4	-	1	572	c.573T>C	c.(571-573)atT>atC	p.I191I		NM_030976.1	NP_112238.1	Q9BYQ5	KRA46_HUMAN	keratin associated protein 4-6	187						keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						GGCAGGTGGAAATGACACAGG	0.627000													2	2					0	0	1	0	0
CSTL1	128817	broad.mit.edu	37	20	23420947	23420947	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr20:23420947G>A	ENST00000347397.1	+	2	289	c.43G>A	c.(43-45)Gcc>Acc	p.A15T	CSTL1_ENST00000246020.2_Missense_Mutation_p.A15T|CSTL1_ENST00000472140.1_3'UTR	NM_138283.1	NP_612140.1	Q9H114	CST1L_HUMAN	cystatin-like 1	15						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(2)|endometrium(2)|large_intestine(3)|lung(4)|skin(2)|stomach(1)	14	Colorectal(13;0.0993)|Lung NSC(19;0.235)					GCTGCTGATTGCCCTGGTCCT	0.537000													17	30					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61511023	61511023	+	Silent	SNP	G	G	T			TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr20:61511023G>T	ENST00000266070.4	-	16	6610	c.6285C>A	c.(6283-6285)ccC>ccA	p.P2095P	DIDO1_ENST00000395343.1_Silent_p.P2095P	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	2095					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GCTTCTCTTTGGGCCCCACGT	0.657000													5	191					0.0293803	0.0293803	1	1	0
OR5K1	26339	broad.mit.edu	37	3	98188581	98188581	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr3:98188581G>A	ENST00000332650.5	+	1	258	c.161G>A	c.(160-162)cGg>cAg	p.R54Q		NM_001004736.2	NP_001004736.2	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K, member 1	54					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(21)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						ACACACCGTCGGCTTCACACA	0.453000													4	228					0	0	1	0	0
ZNF672	79894	broad.mit.edu	37	1	249141581	249141581	+	Silent	SNP	C	C	T			TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr1:249141581C>T	ENST00000306562.3	+	4	854	c.108C>T	c.(106-108)caC>caT	p.H36H		NM_024836.1	NP_079112.1	Q499Z4	ZN672_HUMAN	zinc finger protein 672	36					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(1)	5	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			AACGAGCTCACGGCGGTGACG	0.642000													6	4					0	0	1	0	0
CLPTM1L	81037	broad.mit.edu	37	5	1325911	1325911	+	Silent	SNP	T	T	C			TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr5:1325911T>C	ENST00000320895.5	-	10	1358	c.1101A>G	c.(1099-1101)gcA>gcG	p.A367A	CLPTM1L_ENST00000507807.1_Silent_p.A198A|CLPTM1L_ENST00000320927.6_Silent_p.A331A|CLPTM1L_ENST00000506641.1_5'UTR	NM_030782.3	NP_110409.2	Q96KA5	CLP1L_HUMAN	CLPTM1-like	367					apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24	Lung NSC(6;5.78e-14)|all_lung(6;4.47e-13)|all_epithelial(6;4.47e-09)		Epithelial(17;0.00931)|OV - Ovarian serous cystadenocarcinoma(19;0.0116)|all cancers(22;0.0181)	KIRC - Kidney renal clear cell carcinoma(5;0.177)|Kidney(13;0.208)		TCATCTTCAATGCCTTCTTCA	0.458000													45	71					0	0	1	0	0
PEX5	5830	broad.mit.edu	37	12	7360370	7360370	+	Missense_Mutation	SNP	C	C	T			TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr12:7360370C>T	ENST00000266563.5	+	10	1154	c.971C>T	c.(970-972)gCt>gTt	p.A324V	PEX5_ENST00000420616.2_Missense_Mutation_p.A361V|PEX5_ENST00000455147.2_Missense_Mutation_p.A361V|PEX5_ENST00000434354.2_Missense_Mutation_p.A376V|PEX5_ENST00000266564.3_Missense_Mutation_p.A353V|PEX5_ENST00000412720.2_Missense_Mutation_p.A382V	NM_001131024.1	NP_001124496.1	P50542	PEX5_HUMAN	peroxisomal biogenesis factor 5	361					protein import into peroxisome matrix, translocation|protein targeting to peroxisome|protein tetramerization|protein transport	cytosol|peroxisomal matrix|peroxisomal membrane	peroxisome matrix targeting signal-1 binding|protein C-terminus binding|protein N-terminus binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)	21						TTTGAGGCAGCTGTGCAGCAG	0.547000													10	83					0	0	1	0	0
APC2	10297	broad.mit.edu	37	19	1453055	1453055	+	Missense_Mutation	SNP	A	A	G			TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr19:1453055A>G	ENST00000535453.1	+	1	1768	c.55A>G	c.(55-57)Aag>Gag	p.K19E	APC2_ENST00000233607.2_Missense_Mutation_p.K19E|APC2_ENST00000238483.4_Missense_Mutation_p.K19E			O95996	APC2_HUMAN	adenomatosis polyposis coli 2	19					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|cervix(1)|kidney(4)|large_intestine(2)|lung(5)|pancreas(1)|skin(2)	18		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAGGCCTTGAAGGCTGAGAA	0.622000													4	5					0	0	1	0	0
ESPNP	284729	broad.mit.edu	37	1	17034125	17034126	+	RNA	INS	-	-	AGCT	rs141324796	by1000genomes	TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr1:17034125_17034126insAGCT	ENST00000492551.1	-	0	477_478					NR_026567.1																						CAGCAGCAGCCAGCTGAGCACC	0.718													5	1	---	---	---	---					
ANKRD20A1	84210	broad.mit.edu	37	9	67934791	67934794	+	Frame_Shift_Del	DEL	AAAG	AAAG	-			TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr9:67934791_67934794delAAAG	ENST00000377477.2	+	4	673_676	c.561_564delAAAG	c.(559-564)aafs	p.KK187fs		NM_032250.3	NP_115626.2			ankyrin repeat domain 20 family, member A1											kidney(1)|large_intestine(4)|lung(5)|urinary_tract(1)	11						TTTTATTGAAAAAGAAAGCAAGTT	0.309													3	4	---	---	---	---					
TNRC6B	23112	broad.mit.edu	37	22	40658165	40658165	+	Frame_Shift_Del	DEL	G	G	-			TCGA-WB-A81R-01A-11D-A35I-08	TCGA-WB-A81R-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dde8da2-477b-4451-9961-e409f4d6cb95	faea5994-decf-47e9-a35b-7ab27a79168a	g.chr22:40658165delG	ENST00000454349.2	+	4	656	c.445delG	c.(445-447)ggfs	p.G149fs	TNRC6B_ENST00000335727.8_Frame_Shift_Del_p.G149fs|TNRC6B_ENST00000301923.9_Frame_Shift_Del_p.G185fs|TNRC6B_ENST00000402203.1_Frame_Shift_Del_p.G185fs	NM_001162501.1	NP_001155973.1	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B	149					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding			breast(1)	1						GAGTGAGAGTGGGACTGCGCC	0.567													2	4	---	---	---	---