Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SDHAP3	728609	broad.mit.edu	37	5	1593261	1593261	+	RNA	SNP	A	A	T			TCGA-TT-A6YP-01A-21D-A35I-08	TCGA-TT-A6YP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fc5dbc0-ffda-4944-a0b0-babb48f5eae7	126f9367-4a45-464a-a3f6-7708d2f07961	g.chr5:1593261A>T	ENST00000436493.2	-	0	364																											CTCAGGGCACATGCCTGACCA	0.542000													4	26					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713407	142713407	+	RNA	SNP	C	C	T	rs142431664	by1000genomes	TCGA-TT-A6YP-01A-21D-A35I-08	TCGA-TT-A6YP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fc5dbc0-ffda-4944-a0b0-babb48f5eae7	126f9367-4a45-464a-a3f6-7708d2f07961	g.chr1:142713407C>T	ENST00000369381.2	-	0	1198																											CAGTAAGAAACTCATTCTTAT	0.318000													3	16					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5963272	5963272	+	Silent	SNP	G	G	A			TCGA-TT-A6YP-01A-21D-A35I-08	TCGA-TT-A6YP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fc5dbc0-ffda-4944-a0b0-babb48f5eae7	126f9367-4a45-464a-a3f6-7708d2f07961	g.chr12:5963272G>A	ENST00000327087.8	-	4	629	c.558C>T	c.(556-558)caC>caT	p.H186H	ANO2_ENST00000546188.1_Silent_p.H186H|ANO2_ENST00000356134.5_Silent_p.H186H			Q9NQ90	ANO2_HUMAN	anoctamin 2	190						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						GCCACGGGGCGTGTATCCGGA	0.468000													19	82					0	0	1	0	0
LPPR4	9890	broad.mit.edu	37	1	99772002	99772002	+	Silent	SNP	C	C	T			TCGA-TT-A6YP-01A-21D-A35I-08	TCGA-TT-A6YP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fc5dbc0-ffda-4944-a0b0-babb48f5eae7	126f9367-4a45-464a-a3f6-7708d2f07961	g.chr1:99772002C>T	ENST00000370185.3	+	7	2225	c.1728C>T	c.(1726-1728)atC>atT	p.I576I	LPPR4_ENST00000457765.1_Silent_p.I518I|LPPR4_ENST00000370184.1_Silent_p.I418I	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		576							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		AGCCCCGAATCATGCAAGTCA	0.547000													6	35					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33577007	33577007	+	Missense_Mutation	SNP	T	T	C			TCGA-TT-A6YP-01A-21D-A35I-08	TCGA-TT-A6YP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fc5dbc0-ffda-4944-a0b0-babb48f5eae7	126f9367-4a45-464a-a3f6-7708d2f07961	g.chr5:33577007T>C	ENST00000504830.1	-	19	3459	c.3124A>G	c.(3124-3126)Agc>Ggc	p.S1042G	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.S957G	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1042	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						GTGCTTGTGCTCATAGACTCA	0.537000										HNSCC(64;0.19)			3	38					0	0	1	0	0
ASZ1	136991	broad.mit.edu	37	7	117025822	117025822	+	Missense_Mutation	SNP	T	T	C			TCGA-TT-A6YP-01A-21D-A35I-08	TCGA-TT-A6YP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fc5dbc0-ffda-4944-a0b0-babb48f5eae7	126f9367-4a45-464a-a3f6-7708d2f07961	g.chr7:117025822T>C	ENST00000284629.2	-	5	544	c.482A>G	c.(481-483)cAc>cGc	p.H161R		NM_130768.2	NP_570124.1	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper domain containing 1	161					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(3)|skin(1)	24	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			AACCTGGGTGTGACCATCTCG	0.408000													3	31					0	0	1	0	0
OSBP	5007	broad.mit.edu	37	11	59382787	59382787	+	Silent	SNP	C	C	A			TCGA-TT-A6YP-01A-21D-A35I-08	TCGA-TT-A6YP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fc5dbc0-ffda-4944-a0b0-babb48f5eae7	126f9367-4a45-464a-a3f6-7708d2f07961	g.chr11:59382787C>A	ENST00000263847.1	-	1	830	c.351G>T	c.(349-351)ctG>ctT	p.L117L		NM_002556.2	NP_002547.1	P22059	OSBP1_HUMAN	oxysterol binding protein	117	PH.				lipid transport	Golgi membrane	oxysterol binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		TGTAGTAGCTCAGGAGCCCGT	0.617000													3	9					0.004672	0.004672	1	1	0
FBN3	84467	broad.mit.edu	37	19	8181576	8181576	+	Missense_Mutation	SNP	C	C	T			TCGA-TT-A6YP-01A-21D-A35I-08	TCGA-TT-A6YP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fc5dbc0-ffda-4944-a0b0-babb48f5eae7	126f9367-4a45-464a-a3f6-7708d2f07961	g.chr19:8181576C>T	ENST00000600128.1	-	29	4108	c.3694G>A	c.(3694-3696)Gac>Aac	p.D1232N	FBN3_ENST00000601739.1_Missense_Mutation_p.D1232N|FBN3_ENST00000270509.2_Missense_Mutation_p.D1232N			Q75N90	FBN3_HUMAN	fibrillin 3	1232	EGF-like 17.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						GTCCTCATGTCTGGCGTGGCC	0.617000													15	26					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8130917	8130917	+	Silent	SNP	G	G	C			TCGA-TT-A6YP-01A-21D-A35I-08	TCGA-TT-A6YP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fc5dbc0-ffda-4944-a0b0-babb48f5eae7	126f9367-4a45-464a-a3f6-7708d2f07961	g.chr19:8130917G>C	ENST00000600128.1	-	64	8730	c.8316C>G	c.(8314-8316)acC>acG	p.T2772T	FBN3_ENST00000601739.1_Silent_p.T2772T|FBN3_ENST00000270509.2_Silent_p.T2772T			Q75N90	FBN3_HUMAN	fibrillin 3	2772						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						CCAGCCGGTAGGTTCCAGGCC	0.677000													10	45					0	0	1	0	0
ZNF493	284443	broad.mit.edu	37	19	21607388	21607388	+	Missense_Mutation	SNP	C	C	G			TCGA-TT-A6YP-01A-21D-A35I-08	TCGA-TT-A6YP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fc5dbc0-ffda-4944-a0b0-babb48f5eae7	126f9367-4a45-464a-a3f6-7708d2f07961	g.chr19:21607388C>G	ENST00000392288.2	+	4	2036	c.1927C>G	c.(1927-1929)Cac>Gac	p.H643D	CTD-2561J22.3_ENST00000600810.1_Intron|ZNF493_ENST00000355504.4_Missense_Mutation_p.H515D	NM_001076678.2	NP_001070146.1	Q6ZR52	ZN493_HUMAN	zinc finger protein 493	515					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						GCGGTCCTCACACCTCGCTGG	0.368000													3	36					0	0	1	0	0
ZNF334	55713	broad.mit.edu	37	20	45130892	45130892	+	Silent	SNP	C	C	T	rs140945220		TCGA-TT-A6YP-01A-21D-A35I-08	TCGA-TT-A6YP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fc5dbc0-ffda-4944-a0b0-babb48f5eae7	126f9367-4a45-464a-a3f6-7708d2f07961	g.chr20:45130892C>T	ENST00000457685.2	-	6	2295	c.972G>A	c.(970-972)tcG>tcA	p.S324S	ZNF334_ENST00000347606.4_Silent_p.S362S|ZNF334_ENST00000593880.1_Silent_p.S385S			Q9HCZ1	ZN334_HUMAN	zinc finger protein 334	362					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)				CAACAAGATACGATTTCTTGC	0.458000													4	127					0	0	1	0	0
PAXIP1	22976	broad.mit.edu	37	7	154767578	154767578	+	Missense_Mutation	SNP	C	C	T			TCGA-TT-A6YP-01A-21D-A35I-08	TCGA-TT-A6YP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fc5dbc0-ffda-4944-a0b0-babb48f5eae7	126f9367-4a45-464a-a3f6-7708d2f07961	g.chr7:154767578C>T	ENST00000404141.1	-	6	1056	c.902G>A	c.(901-903)gGt>gAt	p.G301D	PAXIP1_ENST00000397192.1_Missense_Mutation_p.G301D|PAXIP1_ENST00000473219.1_5'UTR			Q6ZW49	PAXI1_HUMAN	PAX interacting (with transcription-activation domain) protein 1	301					DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				NS(1)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	33	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		CAAAATGTTACCTGGGACGGG	0.527000													4	18					0	0	1	0	0
KCNN2	3781	broad.mit.edu	37	5	113698631	113698632	+	In_Frame_Ins	INS	-	-	GCC	rs34838882	by1000genomes	TCGA-TT-A6YP-01A-21D-A35I-08	TCGA-TT-A6YP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fc5dbc0-ffda-4944-a0b0-babb48f5eae7	126f9367-4a45-464a-a3f6-7708d2f07961	g.chr5:113698631_113698632insGCC	ENST00000512097.3	+	2	1177_1178	c.159_160insGCC	c.(157-162)gcccgc>gcGCCccgc	p.53_54AR>APR	KCNN2_ENST00000264773.3_In_Frame_Ins_p.53_54AR>APR			Q9H2S1	KCNN2_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	53	Poly-Ala.					integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		CTGCAGCCGCTGCCGCCGCCGC	0.703													4	8	---	---	---	---					
SUDS3P1	285647	broad.mit.edu	37	5	177398373	177398396	+	RNA	DEL	AGGACGAAGAGCTGGAGAGCGCCA	AGGACGAAGAGCTGGAGAGCGCCA	-	rs70994948		TCGA-TT-A6YP-01A-21D-A35I-08	TCGA-TT-A6YP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fc5dbc0-ffda-4944-a0b0-babb48f5eae7	126f9367-4a45-464a-a3f6-7708d2f07961	g.chr5:177398373_177398396delAGGACGAAGAGCTGGAGAGCGCCA	ENST00000511650.1	+	0	145																											GTCCCCGGGGAGGACGAAGAGCTGGAGAGCGCCAAGGACGACGA	0.683													5	5	---	---	---	---