Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SPATA6L	55064	broad.mit.edu	37	9	4605438	4605438	+	Missense_Mutation	SNP	A	A	C			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chr9:4605438A>C	ENST00000454239.2	-	11	1243	c.998T>G	c.(997-999)tTc>tGc	p.F333C	SPATA6L_ENST00000381890.5_Missense_Mutation_p.S273A|SPATA6L_ENST00000475086.1_Missense_Mutation_p.F275C|SPATA6L_ENST00000381895.5_Missense_Mutation_p.F210C			B4DIY4	B4DIY4_HUMAN	spermatogenesis associated 6-like	275																	ACCAGGATGGAACCTGCTCAA	0.413000													18	34					0	0	1	0	0
ACACA	31	broad.mit.edu	37	17	35627724	35627724	+	Missense_Mutation	SNP	A	A	G			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chr17:35627724A>G	ENST00000353139.5	-	10	1518	c.1037T>C	c.(1036-1038)aTg>aCg	p.M346T	ACACA_ENST00000394406.2_Missense_Mutation_p.M309T|ACACA_ENST00000360679.3_Missense_Mutation_p.M251T|ACACA_ENST00000335166.5_Missense_Mutation_p.M231T	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	309	ATP-grasp.|Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	GGCCTTGATCATTACTGGATA	0.398000													12	85					0	0	1	0	0
RGS8	85397	broad.mit.edu	37	1	182635109	182635109	+	Missense_Mutation	SNP	T	T	C			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chr1:182635109T>C	ENST00000483095.2	-	5	445	c.188A>G	c.(187-189)cAt>cGt	p.H63R	RGS8_ENST00000491420.2_5'UTR|RGS8_ENST00000258302.4_Missense_Mutation_p.H81R|RGS8_ENST00000367556.1_Missense_Mutation_p.H63R|RGS8_ENST00000367557.4_Missense_Mutation_p.H63R			P57771	RGS8_HUMAN	regulator of G-protein signaling 8	63	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			haematopoietic_and_lymphoid_tissue(1)|ovary(1)|stomach(2)|upper_aerodigestive_tract(1)	5						CTTACACTTATGAGAGAGAAG	0.393000													4	112					0	0	1	0	0
PRMT10	90826	broad.mit.edu	37	4	148575325	148575325	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chr4:148575325C>T	ENST00000322396.6	-	9	1965	c.1723G>A	c.(1723-1725)Gta>Ata	p.V575I	PRMT10_ENST00000541232.1_Missense_Mutation_p.V462I|TMEM184C_ENST00000508208.1_Intron	NM_138364.2	NP_612373.2	Q6P2P2	ANM10_HUMAN	protein arginine methyltransferase 10 (putative)	575						cytoplasm	binding|protein methyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28						ATGTTCTGTACAGTATTACTC	0.448000													5	52					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54871235	54871235	+	Missense_Mutation	SNP	T	T	C			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chr3:54871235T>C	ENST00000474759.1	+	15	1496	c.1448T>C	c.(1447-1449)gTg>gCg	p.V483A	CACNA2D3_ENST00000415676.2_Missense_Mutation_p.V483A|CACNA2D3_ENST00000288197.5_Missense_Mutation_p.V483A|CACNA2D3_ENST00000490478.1_Missense_Mutation_p.V389A	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	483	Cache.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		GCCATGCCTGTGTTTAGTAAG	0.542000													4	76					0	0	1	0	0
KDM5C	8242	broad.mit.edu	37	X	53231143	53231143	+	Missense_Mutation	SNP	T	T	C			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chrX:53231143T>C	ENST00000452825.3	-	11	2090	c.1558A>G	c.(1558-1560)Aac>Gac	p.N520D	KDM5C_ENST00000404049.3_Missense_Mutation_p.N586D|KDM5C_ENST00000465402.1_5'UTR|KDM5C_ENST00000375379.3_Missense_Mutation_p.N587D|KDM5C_ENST00000375383.3_Missense_Mutation_p.N546D|KDM5C_ENST00000375401.3_Missense_Mutation_p.N587D	NM_001146702.1	NP_001140174.1	P41229	KDM5C_HUMAN	lysine (K)-specific demethylase 5C	587	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(30)|large_intestine(9)|lung(17)|oesophagus(1)|ovary(6)|prostate(1)|salivary_gland(1)|skin(1)|upper_aerodigestive_tract(2)	82						GCACACTGGTTTGTGCGGACA	0.478000			"""N, F, S"""		clear cell renal carcinoma								10	36					0	0	1	0	0
PAPSS2	9060	broad.mit.edu	37	10	89472868	89472868	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chr10:89472868C>T	ENST00000361175.4	+	3	551	c.182C>T	c.(181-183)gCc>gTc	p.A61V	PAPSS2_ENST00000427144.2_Missense_Mutation_p.A65V|PAPSS2_ENST00000456849.1_Missense_Mutation_p.A61V|PAPSS2_ENST00000482258.1_3'UTR	NM_004670.3	NP_004661.2	O95340	PAPS2_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 2	61					3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|protein binding|sulfate adenylyltransferase (ATP) activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|stomach(1)	20		Melanoma(5;0.019)|Colorectal(252;0.123)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00164)|Colorectal(12;0.000323)|COAD - Colon adenocarcinoma(12;0.00124)		ATAAGTTTTGCCCTGGAGGAG	0.473000													4	131					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35989875	35989875	+	Missense_Mutation	SNP	T	T	A			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chrX:35989875T>A	ENST00000297866.5	+	12	2209	c.2143T>A	c.(2143-2145)Tct>Act	p.S715T		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	715										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						GGAGGAAGAGTCTGTGAGAAG	0.383000													18	27					0	0	1	0	0
VEZT	55591	broad.mit.edu	37	12	95660174	95660174	+	Missense_Mutation	SNP	T	T	G			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chr12:95660174T>G	ENST00000436874.1	+	5	581	c.476T>G	c.(475-477)aTg>aGg	p.M159R	VEZT_ENST00000261219.6_Missense_Mutation_p.M111R|VEZT_ENST00000356859.4_3'UTR	NM_017599.3	NP_060069.3	Q9HBM0	VEZA_HUMAN	vezatin, adherens junctions transmembrane protein	159						acrosomal vesicle|adherens junction|integral to membrane|nucleus				endometrium(2)|kidney(3)|large_intestine(1)|lung(14)|ovary(2)|upper_aerodigestive_tract(1)	23						TTGCTCGTTATGCTTCCCACT	0.408000													96	106					0	0	1	0	0
OR2Y1	134083	broad.mit.edu	37	5	180166493	180166493	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chr5:180166493G>A	ENST00000307832.2	-	1	606	c.566C>T	c.(565-567)gCg>gTg	p.A189V		NM_001001657.1	NP_001001657.1	Q8NGV0	OR2Y1_HUMAN	olfactory receptor, family 2, subfamily Y, member 1	189					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20	all_cancers(89;1.25e-05)|all_epithelial(37;4.36e-06)|Renal(175;0.000159)|Lung NSC(126;0.00317)|all_lung(126;0.0041)|Breast(19;0.114)	all_cancers(40;0.0834)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCTGTGTCCGCACAAGCCAA	0.507000													4	58					0	0	1	0	0
POTEG	404785	broad.mit.edu	37	14	19553785	19553785	+	Silent	SNP	C	C	T			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chr14:19553785C>T	ENST00000409832.3	+	1	421	c.369C>T	c.(367-369)taC>taT	p.Y123Y		NM_001005356.2	NP_001005356.1	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	123										cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(31)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	47						GGGGAGACTACGACGACAGCG	0.592000													5	576					0	0	1	0	0
MXD3	83463	broad.mit.edu	37	5	176737513	176737513	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chr5:176737513G>A	ENST00000427908.2	-	4	302	c.235C>T	c.(235-237)Cgg>Tgg	p.R79W	MXD3_ENST00000513063.1_Missense_Mutation_p.R79W|MXD3_ENST00000423571.2_Missense_Mutation_p.R79W|MXD3_ENST00000439742.2_Missense_Mutation_p.R79W	NM_001142935.1	NP_001136407.1	Q9BW11	MAD3_HUMAN	MAX dimerization protein 3	79	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding					all_cancers(89;2.49e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGCTTCAGCCGCTCCAGGCAC	0.692000													5	9					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29551323	29551323	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chr2:29551323G>A	ENST00000389048.3	-	6	2213	c.1307C>T	c.(1306-1308)gCc>gTc	p.A436V	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	436					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity	p.A436V(1)	ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GCTCTGCAGGGCCATCTTGGA	0.592000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				3	31					0	0	1	0	0
YEATS2	55689	broad.mit.edu	37	3	183504057	183504057	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chr3:183504057G>A	ENST00000305135.5	+	20	3076	c.2881G>A	c.(2881-2883)Gtg>Atg	p.V961M		NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	961					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TTCCCCTGCCGTGGCCCTCTC	0.517000													3	31					0	0	1	0	0
DENND5A	23258	broad.mit.edu	37	11	9225671	9225671	+	Missense_Mutation	SNP	T	T	C			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chr11:9225671T>C	ENST00000328194.3	-	4	805	c.485A>G	c.(484-486)gAt>gGt	p.D162G	DENND5A_ENST00000530044.1_Missense_Mutation_p.D162G	NM_001243254.1|NM_015213.3	NP_001230183.1|NP_056028.2	Q6IQ26	DEN5A_HUMAN	DENN/MADD domain containing 5A	162										breast(1)|endometrium(7)|kidney(2)|large_intestine(8)|liver(1)|lung(16)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						ATGTAGGACATCATACTCAGC	0.507000													3	25					0	0	1	0	0
C14orf28	122525	broad.mit.edu	37	14	45369991	45369991	+	Missense_Mutation	SNP	A	A	G			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chr14:45369991A>G	ENST00000325192.3	+	2	628	c.353A>G	c.(352-354)tAc>tGc	p.Y118C	C14orf28_ENST00000553841.1_3'UTR|C14orf28_ENST00000557112.1_Missense_Mutation_p.Y118C|RP11-857B24.5_ENST00000555157.1_RNA	NM_001017923.1	NP_001017923.1	Q4W4Y0	CN028_HUMAN	chromosome 14 open reading frame 28	118										endometrium(1)|large_intestine(3)|liver(1)|lung(4)|ovary(2)	11						AAACAGCAATACAAATCTGAA	0.323000													3	40					0	0	1	0	0
OR4F6	390648	broad.mit.edu	37	15	102346304	102346304	+	Nonsense_Mutation	SNP	A	A	T			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chr15:102346304A>T	ENST00000328882.4	+	1	403	c.382A>T	c.(382-384)Aag>Tag	p.K128*		NM_001005326.1	NP_001005326.1	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F, member 6	128					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(1)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			GGCCATATGTAAGCCTCTCCA	0.448000													51	138					0	0	1	0	0
PC	5091	broad.mit.edu	37	11	66638898	66638898	+	Silent	SNP	C	C	T			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chr11:66638898C>T	ENST00000393960.1	-	6	656	c.375G>A	c.(373-375)gcG>gcA	p.A125A	PC_ENST00000524491.1_Silent_p.A85A|PC_ENST00000393958.2_Silent_p.A125A|PC_ENST00000355677.3_Silent_p.A125A|PC_ENST00000393955.2_Silent_p.A125A	NM_001040716.1	NP_001035806.1	P11498	PYC_HUMAN	pyruvate carboxylase	125	Biotin carboxylation.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	GGGCGAAGTCCGCTCGCTCAG	0.632000													17	72					0	0	1	0	0
DNASE2B	58511	broad.mit.edu	37	1	84878060	84878060	+	Silent	SNP	C	C	T			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chr1:84878060C>T	ENST00000370665.3	+	5	609	c.576C>T	c.(574-576)aaC>aaT	p.N192N	DNASE2B_ENST00000370662.3_5'UTR	NM_021233.2	NP_067056.2	Q8WZ79	DNS2B_HUMAN	deoxyribonuclease II beta	192					DNA metabolic process	lysosome	deoxyribonuclease II activity			endometrium(1)|lung(4)|skin(1)	6				all cancers(265;0.00303)|Epithelial(280;0.0112)|OV - Ovarian serous cystadenocarcinoma(397;0.0808)		GCAACCCCAACGTCTATAGCT	0.478000													15	34					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140501812	140501812	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chr5:140501812C>T	ENST00000194152.1	+	1	232	c.232C>T	c.(232-234)Cgt>Tgt	p.R78C		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		78	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCAGCTGGATCGTCAGACTGG	0.552000													19	26					0	0	1	0	0
TRDN	10345	broad.mit.edu	37	6	123786033	123786033	+	Frame_Shift_Del	DEL	A	A	-			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chr6:123786033delA	ENST00000546248.1	-	9	1022	c.889delT	c.(889-891)ctfs	p.S297fs	RP11-532N4.2_ENST00000427828.1_RNA|TRDN_ENST00000334268.4_Intron|RP11-532N4.2_ENST00000589182.1_RNA|TRDN_ENST00000398178.3_Intron|RP11-532N4.2_ENST00000418467.2_RNA|RP11-532N4.2_ENST00000587106.1_RNA|RP11-532N4.2_ENST00000434768.1_RNA	NM_001256020.1	NP_001242949.1	Q13061	TRDN_HUMAN	triadin	0					muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	41				GBM - Glioblastoma multiforme(226;0.184)		GATCTTTAAGAAAAAAAAAAG	0.388													2	4	---	---	---	---					
MMS19	64210	broad.mit.edu	37	10	99220451	99220451	+	Splice_Site	DEL	C	C	-			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chr10:99220451delC	ENST00000438925.2	-	25	2805		c.e25+1		MMS19_ENST00000355839.6_Splice_Site|MMS19_ENST00000370782.2_Splice_Site|MMS19_ENST00000327277.7_Splice_Site|MMS19_ENST00000327238.10_Splice_Site	NM_022362.4	NP_071757.4	Q96T76	MMS19_HUMAN	MMS19 nucleotide excision repair homolog (S. cerevisiae)						chromosome segregation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|response to hormone stimulus|transcription, DNA-dependent|two-component signal transduction system (phosphorelay)	cytoplasm|holo TFIIH complex|MMXD complex	estrogen receptor binding|protein binding, bridging|receptor signaling complex scaffold activity|transcription coactivator activity			endometrium(1)|kidney(2)|large_intestine(5)|lung(6)|prostate(1)|stomach(1)	16		Colorectal(252;0.0846)		Epithelial(162;3.33e-10)|all cancers(201;2.74e-08)		AAAGGACGTACCCGGGCTGTA	0.493								Direct reversal of damage					2	4	---	---	---	---					
TESPA1	9840	broad.mit.edu	37	12	55359857	55359857	+	Frame_Shift_Del	DEL	C	C	-			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chr12:55359857delC	ENST00000524622.1	-	5	673	c.12delG	c.(10-12)ggfs	p.G4fs	TESPA1_ENST00000449076.1_Frame_Shift_Del_p.G142fs|TESPA1_ENST00000316577.8_Frame_Shift_Del_p.G142fs|TESPA1_ENST00000531122.1_Frame_Shift_Del_p.G4fs|TESPA1_ENST00000532804.1_Frame_Shift_Del_p.G4fs|TESPA1_ENST00000524959.1_Intron	NM_001261844.1|NM_014796.2	NP_001248773.1|NP_055611.1	A2RU30	K0748_HUMAN	thymocyte expressed, positive selection associated 1	142																	TCTTGTTGGTCCCCCCAGTCA	0.512													2	4	---	---	---	---					
SCAF4	57466	broad.mit.edu	37	21	33044257	33044259	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-QR-A6ZZ-01A-11D-A35D-08	TCGA-QR-A6ZZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42d183e8-221b-4e70-8f87-5945d04bfcc3	b7d26f9e-964c-436f-9e04-437792522c0b	g.chr21:33044257_33044259delGCT	ENST00000286835.7	-	20	3279_3281	c.2897_2899delAGC	c.(2896-2901)cca>c	p.QP966del	SCAF4_ENST00000399804.1_In_Frame_Del_p.QP944del|SCAF4_ENST00000434667.3_In_Frame_Del_p.QP951del	NM_020706.2	NP_065757.1	O95104	SFR15_HUMAN	SR-related CTD-associated factor 4	966	Poly-Gln.					nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(11)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						GATGGTGgtggctgctgctgctg	0.581													8	107	---	---	---	---