Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	filter
RNF207	388591	broad.mit.edu	37	1	6272365	6272365	+	Silent	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:6272365G>T	uc001amg.2	+	14	1545	c.1371G>T	c.(1369-1371)TCG>TCT	p.S457S	RNF207_uc010nzp.1_RNA	NM_207396	NP_997279	Q6ZRF8	RN207_HUMAN	ring finger protein 207	457	Potential.					intracellular	zinc ion binding				0	Ovarian(185;0.0634)	all_cancers(23;1.22e-38)|all_epithelial(116;4.25e-22)|all_lung(118;7.95e-08)|Lung NSC(185;1.6e-06)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;4.84e-38)|GBM - Glioblastoma multiforme(13;5.77e-32)|OV - Ovarian serous cystadenocarcinoma(86;2.88e-19)|Colorectal(212;6.9e-08)|COAD - Colon adenocarcinoma(227;8.13e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.00311)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		AGCACCACTCGCTCATCAAGG	0.607													11	59	---	---	---	---	PASS
C1orf200	644997	broad.mit.edu	37	1	9714484	9714484	+	Missense_Mutation	SNP	T	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:9714484T>A	uc001aqc.3	-	1	161	c.11A>T	c.(10-12)CAG>CTG	p.Q4L	PIK3CD_uc001aqa.2_Intron|PIK3CD_uc001aqb.3_Intron	NR_027045				RecName: Full=Putative uncharacterized protein C1orf200;												0	all_lung(157;0.222)	Renal(390;0.000469)|all_lung(118;0.000521)|Lung NSC(185;0.000744)|Colorectal(325;0.0062)|Breast(348;0.0157)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.86e-08)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(185;0.000231)|KIRC - Kidney renal clear cell carcinoma(229;0.000879)|BRCA - Breast invasive adenocarcinoma(304;0.00178)|STAD - Stomach adenocarcinoma(132;0.00331)|READ - Rectum adenocarcinoma(331;0.0419)		GCAGGCAGACTGGGAGGGCAT	0.572													11	63	---	---	---	---	PASS
CLCNKB	1188	broad.mit.edu	37	1	16375649	16375649	+	Missense_Mutation	SNP	C	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:16375649C>G	uc001axw.3	+	8	770	c.690C>G	c.(688-690)CAC>CAG	p.H230Q	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Missense_Mutation_p.H230Q|CLCNKB_uc001axy.3_Missense_Mutation_p.H61Q	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	230					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		TGTCTTCCCACTTCTCTGTCT	0.637													14	133	---	---	---	---	PASS
HSPG2	3339	broad.mit.edu	37	1	22175404	22175404	+	Missense_Mutation	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:22175404G>A	uc001bfj.2	-	58	7607	c.7567C>T	c.(7567-7569)CGC>TGC	p.R2523C	HSPG2_uc009vqd.2_Missense_Mutation_p.R2524C	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2523	Ig-like C2-type 10.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CCACTAAGGCGCTGCTGGATG	0.632													16	112	---	---	---	---	PASS
HSPG2	3339	broad.mit.edu	37	1	22181477	22181477	+	Splice_Site	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:22181477C>A	uc001bfj.2	-	48	6038	c.5998_splice	c.e48-1	p.A2000_splice	HSPG2_uc009vqd.2_Splice_Site_p.A2001_splice	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor						angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CTGACCGGGCCTGCCGTGGGT	0.652													5	49	---	---	---	---	PASS
C1QB	713	broad.mit.edu	37	1	22987582	22987582	+	Silent	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:22987582C>T	uc001bgd.2	+	3	597	c.465C>T	c.(463-465)CCC>CCT	p.P155P		NM_000491	NP_000482	P02746	C1QB_HUMAN	complement component 1, q subcomponent, B chain	155	C1q.				complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				breast(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.06e-27)|Colorectal(126;1.58e-07)|GBM - Glioblastoma multiforme(114;6.72e-06)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000551)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	ATTATGAGCCCCGCAGTGGCA	0.592													10	89	---	---	---	---	PASS
HDAC1	3065	broad.mit.edu	37	1	32796447	32796447	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:32796447G>T	uc001bvb.1	+	9	980	c.917G>T	c.(916-918)CGT>CTT	p.R306L	HDAC1_uc010ohf.1_Missense_Mutation_p.R277L|HDAC1_uc001bvc.1_Missense_Mutation_p.R62L	NM_004964	NP_004955	Q13547	HDAC1_HUMAN	histone deacetylase 1	306	Histone deacetylase.				anti-apoptosis|blood coagulation|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|histone H3 deacetylation|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of androgen receptor signaling pathway|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytosol|NuRD complex|Sin3 complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|identical protein binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|RNA polymerase II transcription corepressor activity|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|breast(1)	3		Breast(348;0.000523)|Lung NSC(340;0.000992)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Lung SC(1967;0.113)		KIRC - Kidney renal clear cell carcinoma(1967;0.138)	Vorinostat(DB02546)	TACACCATTCGTAACGTTGCC	0.562													14	72	---	---	---	---	PASS
CSMD2	114784	broad.mit.edu	37	1	34180320	34180320	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:34180320C>A	uc001bxn.1	-	21	3182	c.3153G>T	c.(3151-3153)AAG>AAT	p.K1051N	CSMD2_uc001bxm.1_Missense_Mutation_p.K1091N	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1051	Sushi 6.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				ACTGCAAGCCCTTCCGGATGC	0.652													24	62	---	---	---	---	PASS
PABPC4	8761	broad.mit.edu	37	1	40031023	40031023	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:40031023C>T	uc010oiv.1	-	8	1898	c.1000G>A	c.(1000-1002)GGG>AGG	p.G334R	PABPC4_uc001cdl.2_Missense_Mutation_p.G334R|PABPC4_uc001cdm.2_Missense_Mutation_p.G334R	NM_003819	NP_003810	Q13310	PABP4_HUMAN	poly A binding protein, cytoplasmic 4 isoform 2	334	RRM 4.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding				0	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			AAGCCAAACCCTTTGCTTCTT	0.393													14	84	---	---	---	---	PASS
KDM4A	9682	broad.mit.edu	37	1	44121382	44121382	+	Missense_Mutation	SNP	A	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:44121382A>G	uc001cjx.2	+	3	425	c.259A>G	c.(259-261)ATA>GTA	p.I87V	KDM4A_uc010oki.1_Missense_Mutation_p.I87V	NM_014663	NP_055478	O75164	KDM4A_HUMAN	jumonji domain containing 2A	87					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1						TCAGTACAACATACAGAAGAA	0.488													10	75	---	---	---	---	PASS
ZSWIM5	57643	broad.mit.edu	37	1	45484728	45484728	+	Missense_Mutation	SNP	T	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:45484728T>C	uc001cnd.2	-	14	3184	c.2956A>G	c.(2956-2958)ATT>GTT	p.I986V		NM_020883	NP_065934	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM domain containing 5	986							zinc ion binding				0	Acute lymphoblastic leukemia(166;0.155)					TCAATGGCAATCTGGTAGGCT	0.547											OREG0013450	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	129	---	---	---	---	PASS
FAAH	2166	broad.mit.edu	37	1	46871137	46871137	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:46871137G>T	uc001cpu.2	+	4	620	c.538G>T	c.(538-540)GTG>TTG	p.V180L	FAAH_uc001cpv.2_5'Flank	NM_001441	NP_001432	O00519	FAAH1_HUMAN	fatty acid amide hydrolase	180	Cytoplasmic (By similarity).				fatty acid catabolic process	cytoplasm|cytoskeleton|endomembrane system|integral to membrane|organelle membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|fatty acid amide hydrolase activity			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(166;0.155)				Propofol(DB00818)|Thiopental(DB00599)	GCAGGGTGCCGTGCCCTTCGT	0.667													28	128	---	---	---	---	PASS
KIAA0494	9813	broad.mit.edu	37	1	47154048	47154048	+	Nonsense_Mutation	SNP	T	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:47154048T>A	uc001cqk.3	-	7	1941	c.964A>T	c.(964-966)AAA>TAA	p.K322*	KIAA0494_uc010omh.1_Intron|KIAA0494_uc010omj.1_Intron|KIAA0494_uc001cql.1_Nonsense_Mutation_p.K322*	NM_014774	NP_055589	O75071	K0494_HUMAN	hypothetical protein LOC9813	322							calcium ion binding				0	Acute lymphoblastic leukemia(166;0.155)					AGGTTTGCTTTCTTTTCTACC	0.418													27	107	---	---	---	---	PASS
PCSK9	255738	broad.mit.edu	37	1	55509579	55509579	+	Missense_Mutation	SNP	T	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:55509579T>A	uc001cyf.1	+	2	562	c.271T>A	c.(271-273)TCA>ACA	p.S91T	PCSK9_uc010ool.1_RNA|PCSK9_uc010oom.1_Intron	NM_174936	NP_777596	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	91					cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding			ovary(2)|central_nervous_system(1)|skin(1)	4						CCTCTCGCAGTCAGAGCGCAC	0.627													9	66	---	---	---	---	PASS
LRRC7	57554	broad.mit.edu	37	1	70144063	70144063	+	Splice_Site	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:70144063G>T	uc001deo.1	+	2	1458	c.3_splice	c.e2-1	p.M1_splice				Q96NW7	LRRC7_HUMAN	SubName: Full=Leucine rich repeat containing 7; SubName: Full=cDNA FLJ54846, highly similar to Leucine-rich repeat-containing protein 7;							centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						CTCTCTTATAGGATGGAGAAC	0.398													3	17	---	---	---	---	PASS
C1orf173	127254	broad.mit.edu	37	1	75086533	75086533	+	Silent	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:75086533C>A	uc001dgg.2	-	8	1104	c.885G>T	c.(883-885)GGG>GGT	p.G295G	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Silent_p.G89G	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	295										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						GCACATTTTTCCCCAAATAGA	0.363													21	64	---	---	---	---	PASS
ELTD1	64123	broad.mit.edu	37	1	79386071	79386071	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:79386071C>T	uc001diq.3	-	10	1414	c.1258G>A	c.(1258-1260)GGT>AGT	p.G420S		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	420	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		TCTTTAATACCCTAAGGGAAA	0.289													5	49	---	---	---	---	PASS
GTF2B	2959	broad.mit.edu	37	1	89322940	89322940	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:89322940C>A	uc001dmo.3	-	6	885	c.766G>T	c.(766-768)GCA>TCA	p.A256S		NM_001514	NP_001505	Q00403	TF2B_HUMAN	general transcription factor IIB	256	2.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	thyroid hormone receptor binding|translation initiation factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0131)|Epithelial(280;0.0255)		TAAATAGCTGCCGCTGCCACA	0.493													18	103	---	---	---	---	PASS
RBMXL1	494115	broad.mit.edu	37	1	89448597	89448597	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:89448597C>A	uc009wcx.2	-	3	1629	c.913G>T	c.(913-915)GGT>TGT	p.G305C	CCBL2_uc001dmp.2_Intron|CCBL2_uc001dmq.2_Intron|CCBL2_uc001dmr.2_Intron|RBMXL1_uc001dms.2_Missense_Mutation_p.G305C	NM_001162536	NP_001156008	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	305	Ser-rich.						nucleotide binding|RNA binding				0						CTGCTTCCACCATAAGATGGC	0.473													58	205	---	---	---	---	PASS
GBP2	2634	broad.mit.edu	37	1	89583373	89583373	+	Missense_Mutation	SNP	C	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:89583373C>G	uc001dmz.1	-	5	783	c.512G>C	c.(511-513)AGC>ACC	p.S171T	GBP2_uc001dmy.1_RNA	NM_004120	NP_004111	P32456	GBP2_HUMAN	guanylate binding protein 2,	171					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)	1		Lung NSC(277;0.0908)		all cancers(265;0.0151)|Epithelial(280;0.0284)		TGGAAAAAAGCTCACAAAGTC	0.448													26	72	---	---	---	---	PASS
ALX3	257	broad.mit.edu	37	1	110604103	110604103	+	Missense_Mutation	SNP	G	T	T	rs140822231		TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:110604103G>T	uc001dzb.2	-	3	765	c.677C>A	c.(676-678)GCT>GAT	p.A226D		NM_006492	NP_006483	O95076	ALX3_HUMAN	aristaless-like homeobox 3	226						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(81;2.35e-05)|all_epithelial(167;7.69e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.015)|all cancers(265;0.0706)|Epithelial(280;0.0758)|Colorectal(144;0.113)|LUSC - Lung squamous cell carcinoma(189;0.135)		GTCATAGGCAGCCGTGAAGGG	0.607													21	64	---	---	---	---	PASS
OLFML3	56944	broad.mit.edu	37	1	114524239	114524239	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:114524239C>T	uc001eer.1	+	3	1178	c.1069C>T	c.(1069-1071)CCT>TCT	p.P357S	OLFML3_uc001ees.1_Missense_Mutation_p.P337S|OLFML3_uc001eet.1_Missense_Mutation_p.P213S	NM_020190	NP_064575	Q9NRN5	OLFL3_HUMAN	olfactomedin-like 3 precursor	357	Olfactomedin-like.				multicellular organismal development	extracellular region					0	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CACCCTGACCCCTGAACGGGC	0.597													17	47	---	---	---	---	PASS
FCRL2	79368	broad.mit.edu	37	1	157745576	157745576	+	Missense_Mutation	SNP	G	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:157745576G>C	uc001fre.2	-	2	100	c.41C>G	c.(40-42)ACT>AGT	p.T14S	FCRL2_uc010phz.1_Missense_Mutation_p.T14S|FCRL2_uc009wsp.2_Missense_Mutation_p.T14S|FCRL2_uc010pia.1_Missense_Mutation_p.T14S	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	14					cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TGCCTGTTCAGTGACTGCATC	0.433													4	33	---	---	---	---	PASS
FCRLA	84824	broad.mit.edu	37	1	161681143	161681143	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:161681143G>T	uc001gbe.2	+	4	689	c.447G>T	c.(445-447)AGG>AGT	p.R149S	FCRLA_uc001gbd.2_Missense_Mutation_p.R143S|FCRLA_uc001gbf.2_Intron|FCRLA_uc001gbg.2_Intron|FCRLA_uc009wuo.2_Intron|FCRLA_uc009wup.2_Intron|FCRLA_uc009wuq.2_Intron	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	126	Ig-like C2-type 1.				cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			GGCCTAACAGGGAATTCTCCA	0.602													8	55	---	---	---	---	PASS
LRRC52	440699	broad.mit.edu	37	1	165514029	165514029	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:165514029G>T	uc001gde.2	+	1	552	c.496G>T	c.(496-498)GAC>TAC	p.D166Y	LOC400794_uc001gdc.2_Intron|LOC400794_uc001gdd.2_Intron|LOC400794_uc009wvd.2_Intron	NM_001005214	NP_001005214	Q8N7C0	LRC52_HUMAN	leucine rich repeat containing 52 precursor	166	Extracellular (Potential).|LRR 5.					integral to membrane				ovary(1)	1	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)					GCAGACCCTGGACAGTGCTGC	0.517													41	166	---	---	---	---	PASS
DUSP27	92235	broad.mit.edu	37	1	167096615	167096615	+	Silent	SNP	G	C	C	rs140729613	byFrequency	TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:167096615G>C	uc001geb.1	+	5	2247	c.2247G>C	c.(2245-2247)CCG>CCC	p.P749P		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	749					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						CCCGCTCACCGTCTGTTGCAA	0.537													14	59	---	---	---	---	PASS
SELP	6403	broad.mit.edu	37	1	169578860	169578860	+	Silent	SNP	C	A	A	rs138017338	byFrequency	TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:169578860C>A	uc001ggi.3	-	8	1280	c.1215G>T	c.(1213-1215)GCG>GCT	p.A405A	SELP_uc001ggh.2_Silent_p.A240A|SELP_uc009wvr.2_Silent_p.A405A	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	405	Sushi 4.|Extracellular (Potential).				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	CATACTGAAACGCTCTCAAGG	0.498													15	65	---	---	---	---	PASS
TNN	63923	broad.mit.edu	37	1	175046707	175046707	+	Silent	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:175046707C>A	uc001gkl.1	+	2	266	c.153C>A	c.(151-153)CCC>CCA	p.P51P	TNN_uc010pmx.1_Silent_p.P51P	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	51					cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TCGATGTGCCCAAGTCTGCCT	0.617													15	39	---	---	---	---	PASS
RGL1	23179	broad.mit.edu	37	1	183816796	183816796	+	Missense_Mutation	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:183816796G>A	uc001gqo.2	+	3	392	c.235G>A	c.(235-237)GAG>AAG	p.E79K	RGL1_uc010pof.1_Intron|RGL1_uc001gqm.2_Missense_Mutation_p.E114K|RGL1_uc010pog.1_Missense_Mutation_p.E77K|RGL1_uc010poh.1_Missense_Mutation_p.E77K|RGL1_uc010poi.1_Missense_Mutation_p.E79K	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	79	N-terminal Ras-GEF.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						GAAGCTTGTGGAGAACCTGCT	0.473													23	138	---	---	---	---	PASS
C1orf25	81627	broad.mit.edu	37	1	185109335	185109335	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:185109335C>A	uc001grf.3	-	8	1151	c.879G>T	c.(877-879)TGG>TGT	p.W293C	C1orf25_uc010pon.1_Missense_Mutation_p.W137C	NM_030934	NP_112196	Q7Z2T5	TRM1L_HUMAN	N2,N2-dimethylguanosine tRNA	293						intracellular	RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding				0						GATGTTTTGCCCACTGTAATC	0.294													4	53	---	---	---	---	PASS
FAM5C	339479	broad.mit.edu	37	1	190234052	190234052	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:190234052G>T	uc001gse.1	-	4	793	c.561C>A	c.(559-561)GAC>GAA	p.D187E	FAM5C_uc010pot.1_Missense_Mutation_p.D85E	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	187						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TGCTGTCCCTGTCAATGAAAT	0.453													12	85	---	---	---	---	PASS
OBSCN	84033	broad.mit.edu	37	1	228444413	228444413	+	Silent	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:228444413G>A	uc009xez.1	+	15	4415	c.4371G>A	c.(4369-4371)GGG>GGA	p.G1457G	OBSCN_uc001hsn.2_Silent_p.G1457G	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1457	Ig-like 15.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CCCAGGCGGGGGCCAGCACCA	0.622													5	50	---	---	---	---	PASS
RYR2	6262	broad.mit.edu	37	1	237754118	237754118	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:237754118G>T	uc001hyl.1	+	31	4106	c.3986G>T	c.(3985-3987)GGG>GTG	p.G1329V		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1329	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGCCTTTTTGGGCCCAAGAAT	0.517													25	89	---	---	---	---	PASS
TFB2M	64216	broad.mit.edu	37	1	246719931	246719931	+	Missense_Mutation	SNP	T	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:246719931T>C	uc001ibn.2	-	4	774	c.649A>G	c.(649-651)ATA>GTA	p.I217V	TFB2M_uc010pys.1_RNA	NM_022366	NP_071761	Q9H5Q4	TFB2M_HUMAN	transcription factor B2, mitochondrial	217					positive regulation of transcription, DNA-dependent|transcription initiation from mitochondrial promoter	mitochondrial nucleoid	protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity|transcription cofactor activity			ovary(1)	1	all_cancers(71;4.25e-05)|all_epithelial(71;4.92e-06)|Ovarian(71;0.0254)|all_lung(81;0.0272)|Breast(184;0.0318)|Lung NSC(105;0.0376)		OV - Ovarian serous cystadenocarcinoma(106;0.00358)			AATTTATATATAGAAGTACAG	0.328													10	68	---	---	---	---	PASS
OR2L8	391190	broad.mit.edu	37	1	248112719	248112719	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:248112719C>A	uc001idt.1	+	1	560	c.560C>A	c.(559-561)GCC>GAC	p.A187D	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			GTGACTCTGGCCTGCATGGAC	0.468													5	67	---	---	---	---	PASS
OR2L3	391192	broad.mit.edu	37	1	248224543	248224543	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:248224543C>A	uc001idx.1	+	1	560	c.560C>A	c.(559-561)GCC>GAC	p.A187D	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			GTGACTCTGGCCTGCATGGAC	0.468													4	97	---	---	---	---	PASS
OR2T1	26696	broad.mit.edu	37	1	248569946	248569946	+	Silent	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr1:248569946C>T	uc010pzm.1	+	1	651	c.651C>T	c.(649-651)CCC>CCT	p.P217P		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	217	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGAGCTTTCCCTTCTGCAATT	0.532													6	70	---	---	---	---	PASS
XDH	7498	broad.mit.edu	37	2	31598392	31598392	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr2:31598392C>A	uc002rnv.1	-	15	1535	c.1456G>T	c.(1456-1458)GTG>TTG	p.V486L		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	486					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CCTGCACACACGTCCTGCAGC	0.637													14	42	---	---	---	---	PASS
LTBP1	4052	broad.mit.edu	37	2	33568004	33568004	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr2:33568004C>T	uc002ros.2	+	25	3833	c.3833C>T	c.(3832-3834)GCC>GTC	p.A1278V	LTBP1_uc002rot.2_Missense_Mutation_p.A952V|LTBP1_uc002rou.2_Missense_Mutation_p.A951V|LTBP1_uc002rov.2_Missense_Mutation_p.A898V|LTBP1_uc010ymz.1_Intron|LTBP1_uc010yna.1_Intron|LTBP1_uc010ynb.1_Intron	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1277	EGF-like 13; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GGCTTTCAAGCCCCACAGGAT	0.463													7	66	---	---	---	---	PASS
ETAA1	54465	broad.mit.edu	37	2	67632417	67632417	+	Missense_Mutation	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr2:67632417G>A	uc002sdz.1	+	5	2742	c.2603G>A	c.(2602-2604)GGA>GAA	p.G868E		NM_019002	NP_061875	Q9NY74	ETAA1_HUMAN	ETAA16 protein	868						cytoplasm|nucleus				ovary(3)|large_intestine(1)	4						GAAGCTGTTGGACAGCAATCT	0.323													3	48	---	---	---	---	PASS
HTRA2	27429	broad.mit.edu	37	2	74757145	74757145	+	Silent	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr2:74757145G>A	uc002smi.1	+	1	614	c.12G>A	c.(10-12)CCG>CCA	p.P4P	AUP1_uc002sme.2_5'Flank|AUP1_uc002smf.2_5'Flank|AUP1_uc002smg.2_5'Flank|AUP1_uc002smh.2_5'Flank|AUP1_uc010yrx.1_5'Flank|AUP1_uc010yry.1_5'Flank|HTRA2_uc002smj.1_Silent_p.P4P|HTRA2_uc002smk.1_Silent_p.P4P|HTRA2_uc002sml.1_Silent_p.P4P|HTRA2_uc002smm.1_Intron|HTRA2_uc002smn.1_Intron|HTRA2_uc010ffl.2_5'Flank	NM_013247	NP_037379	O43464	HTRA2_HUMAN	HtrA serine peptidase 2 isoform 1 preproprotein	4					apoptosis|proteolysis|response to stress	CD40 receptor complex|endoplasmic reticulum membrane|internal side of plasma membrane|mitochondrial intermembrane space|mitochondrial membrane|nucleus	serine-type endopeptidase activity|unfolded protein binding			ovary(1)	1						TGGCTGCGCCGAGGGCGGGGC	0.741													12	71	---	---	---	---	PASS
REG1A	5967	broad.mit.edu	37	2	79348720	79348720	+	Missense_Mutation	SNP	C	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr2:79348720C>G	uc002snz.2	+	3	200	c.97C>G	c.(97-99)CGG>GGG	p.R33G	REG1A_uc010ffx.1_Missense_Mutation_p.R33G|REG1A_uc010ysd.1_Missense_Mutation_p.R33G	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	33					positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						GCCCCAGGCCCGGATCAGCTG	0.522													36	294	---	---	---	---	PASS
SMYD1	150572	broad.mit.edu	37	2	88367421	88367421	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr2:88367421C>A	uc002ssr.2	+	1	40	c.38C>A	c.(37-39)ACC>AAC	p.T13N	SMYD1_uc002ssq.1_Missense_Mutation_p.T8N	NM_198274	NP_938015	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	13					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						GAGGTCTTCACCGCTGAGGGC	0.522													37	221	---	---	---	---	PASS
SMYD1	150572	broad.mit.edu	37	2	88396283	88396283	+	Missense_Mutation	SNP	G	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr2:88396283G>C	uc002ssr.2	+	6	870	c.868G>C	c.(868-870)GGG>CGG	p.G290R	SMYD1_uc002ssq.1_Intron|SMYD1_uc002sss.2_5'UTR	NM_198274	NP_938015	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	290					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						CCTCTTCCTGGGGGTGAAAGA	0.507													15	68	---	---	---	---	PASS
SMYD1	150572	broad.mit.edu	37	2	88402583	88402583	+	Missense_Mutation	SNP	C	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr2:88402583C>G	uc002ssr.2	+	7	897	c.895C>G	c.(895-897)CAG>GAG	p.Q299E	SMYD1_uc002ssq.1_Intron|SMYD1_uc002sss.2_5'UTR	NM_198274	NP_938015	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	299					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						CCAGCCCTCTCAGGAAGTGGT	0.413													11	67	---	---	---	---	PASS
ST6GAL2	84620	broad.mit.edu	37	2	107423361	107423361	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr2:107423361C>T	uc002tdq.2	-	6	1482	c.1363G>A	c.(1363-1365)GAA>AAA	p.E455K	ST6GAL2_uc002tdr.2_Missense_Mutation_p.E455K	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	455	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						GGGATATATTCATACACGTGC	0.502													4	27	---	---	---	---	PASS
GLI2	2736	broad.mit.edu	37	2	121685040	121685040	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr2:121685040C>A	uc010flp.2	+	2	282	c.252C>A	c.(250-252)CAC>CAA	p.H84Q	GLI2_uc010yyu.1_Missense_Mutation_p.H84Q|GLI2_uc002tmp.1_Missense_Mutation_p.H84Q|GLI2_uc010fln.1_RNA|GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Intron|GLI2_uc002tmu.3_Intron|GLI2_uc002tmv.1_Missense_Mutation_p.H84Q|GLI2_uc010flo.1_Intron|GLI2_uc002tmw.1_Missense_Mutation_p.H84Q	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	84					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				ACGGTGTGCACGGGTAAGTCC	0.612													64	98	---	---	---	---	PASS
CNTNAP5	129684	broad.mit.edu	37	2	124783296	124783296	+	Missense_Mutation	SNP	A	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr2:124783296A>T	uc002tno.2	+	1	433	c.69A>T	c.(67-69)TTA>TTT	p.L23F	CNTNAP5_uc010flu.2_Missense_Mutation_p.L23F	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	23					cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		ATTTAGGATTAACAGCGACAA	0.502													20	74	---	---	---	---	PASS
NCKAP5	344148	broad.mit.edu	37	2	133539769	133539769	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr2:133539769C>A	uc002ttp.2	-	14	4989	c.4615G>T	c.(4615-4617)GTC>TTC	p.V1539F	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1539							protein binding				0						AACCCCAAGACTTTTGCATCT	0.393													52	142	---	---	---	---	PASS
NCKAP5	344148	broad.mit.edu	37	2	133636486	133636486	+	Nonsense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr2:133636486C>A	uc002ttp.2	-	9	957	c.583G>T	c.(583-585)GAG>TAG	p.E195*	NCKAP5_uc002ttq.2_Nonsense_Mutation_p.E195*	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	195	Potential.						protein binding				0						GCTGAATTCTCTGCCTGCAGT	0.388													16	68	---	---	---	---	PASS
LRP1B	53353	broad.mit.edu	37	2	141359163	141359163	+	Missense_Mutation	SNP	G	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr2:141359163G>C	uc002tvj.1	-	42	7817	c.6845C>G	c.(6844-6846)ACA>AGA	p.T2282R		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2282	Extracellular (Potential).|LDL-receptor class B 24.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCAGTACAGTGTATCCCAGGC	0.448										TSP Lung(27;0.18)			12	44	---	---	---	---	PASS
SLC4A10	57282	broad.mit.edu	37	2	162760661	162760661	+	Silent	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr2:162760661G>T	uc002ubx.3	+	13	1774	c.1590G>T	c.(1588-1590)CTG>CTT	p.L530L	SLC4A10_uc010zcr.1_RNA|SLC4A10_uc002uby.3_Silent_p.L500L|SLC4A10_uc010zcs.1_Silent_p.L511L	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	530	Helical; (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						TTGGAGGACTGCTGGGAGAAG	0.408													7	18	---	---	---	---	PASS
COL3A1	1281	broad.mit.edu	37	2	189868786	189868786	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr2:189868786C>A	uc002uqj.1	+	39	2857	c.2740C>A	c.(2740-2742)CCT>ACT	p.P914T		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	914	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CACTGGTGCTCCTGGCAGCCC	0.567													4	40	---	---	---	---	PASS
SATB2	23314	broad.mit.edu	37	2	200298194	200298194	+	Silent	SNP	G	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr2:200298194G>C	uc002uuy.1	-	3	1030	c.213C>G	c.(211-213)GGC>GGG	p.G71G	SATB2_uc010fsq.1_Silent_p.G71G|SATB2_uc002uuz.1_Silent_p.G71G|SATB2_uc002uva.1_Silent_p.G71G	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	71						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						ATTCAAGAGAGCCGTCCAACT	0.473													23	118	---	---	---	---	PASS
HDAC4	9759	broad.mit.edu	37	2	240029801	240029801	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr2:240029801C>T	uc002vyk.3	-	15	2834	c.2042G>A	c.(2041-2043)AGG>AAG	p.R681K	HDAC4_uc010fyz.1_Missense_Mutation_p.R676K|HDAC4_uc010zoa.1_Missense_Mutation_p.R681K|HDAC4_uc010fza.2_Missense_Mutation_p.R686K|HDAC4_uc010fyy.2_Missense_Mutation_p.R638K|HDAC4_uc010znz.1_Missense_Mutation_p.R564K	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	681	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		GCTCTGGATCCTCCCGGCGTG	0.692													6	27	---	---	---	---	PASS
CNTN6	27255	broad.mit.edu	37	3	1414067	1414067	+	Missense_Mutation	SNP	A	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr3:1414067A>T	uc003boz.2	+	13	1844	c.1577A>T	c.(1576-1578)GAC>GTC	p.D526V	CNTN6_uc011asj.1_Missense_Mutation_p.D454V|CNTN6_uc003bpa.2_Missense_Mutation_p.D526V	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	526	Ig-like C2-type 6.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		GTGTCCCATGACCCCTCCATT	0.413													10	55	---	---	---	---	PASS
ATP2B2	491	broad.mit.edu	37	3	10370598	10370598	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr3:10370598C>A	uc003bvt.2	-	23	4071	c.3632G>T	c.(3631-3633)AGC>ATC	p.S1211I	ATP2B2_uc003bvv.2_Missense_Mutation_p.S1166I|ATP2B2_uc003bvw.2_Missense_Mutation_p.S1166I|ATP2B2_uc003bvs.2_RNA|ATP2B2_uc010hdo.2_Missense_Mutation_p.S916I|hsa-mir-378b|MI0014154_5'Flank	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	1211	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						GTCGATGGCGCTGTTGTTCTT	0.577													15	48	---	---	---	---	PASS
HRH1	3269	broad.mit.edu	37	3	11300949	11300949	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr3:11300949G>T	uc010hdr.2	+	2	568	c.226G>T	c.(226-228)GTG>TTG	p.V76L	HRH1_uc010hds.2_Missense_Mutation_p.V76L|HRH1_uc010hdt.2_Missense_Mutation_p.V76L|HRH1_uc003bwb.3_Missense_Mutation_p.V76L	NM_001098213	NP_001091683	P35367	HRH1_HUMAN	histamine receptor H1	76	Helical; Name=2; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			large_intestine(1)|ovary(1)	2					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	GGACTTGATCGTGGGTGCCGT	0.572													26	68	---	---	---	---	PASS
OXSM	54995	broad.mit.edu	37	3	25832949	25832949	+	Silent	SNP	T	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr3:25832949T>A	uc003cdn.2	+	2	545	c.438T>A	c.(436-438)ACT>ACA	p.T146T	NGLY1_uc011awo.1_5'Flank|OXSM_uc011awp.1_Intron|OXSM_uc010hfh.2_Silent_p.T146T	NM_017897	NP_060367	Q9NWU1	OXSM_HUMAN	3-oxoacyl-ACP synthase, mitochondrial isoform 1	146					acyl-CoA metabolic process|medium-chain fatty acid biosynthetic process|short-chain fatty acid biosynthetic process	mitochondrion	3-oxoacyl-[acyl-carrier-protein] synthase activity			ovary(1)|breast(1)	2						AAGTGGCTACTGGTGTTGCAA	0.438													34	87	---	---	---	---	PASS
OXSM	54995	broad.mit.edu	37	3	25832953	25832953	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr3:25832953G>T	uc003cdn.2	+	2	549	c.442G>T	c.(442-444)GTT>TTT	p.V148F	NGLY1_uc011awo.1_5'Flank|OXSM_uc011awp.1_Intron|OXSM_uc010hfh.2_Missense_Mutation_p.V148F	NM_017897	NP_060367	Q9NWU1	OXSM_HUMAN	3-oxoacyl-ACP synthase, mitochondrial isoform 1	148					acyl-CoA metabolic process|medium-chain fatty acid biosynthetic process|short-chain fatty acid biosynthetic process	mitochondrion	3-oxoacyl-[acyl-carrier-protein] synthase activity			ovary(1)|breast(1)	2						GGCTACTGGTGTTGCAATTGG	0.443													36	85	---	---	---	---	PASS
ERC2	26059	broad.mit.edu	37	3	55922476	55922476	+	Silent	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr3:55922476C>A	uc003dhr.1	-	14	2761	c.2505G>T	c.(2503-2505)GCG>GCT	p.A835A	ERC2_uc003dhq.1_RNA|ERC2_uc003dht.1_Silent_p.A314A	NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	835	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TGGCCAAGTGCGCTTCTTTTT	0.537													42	140	---	---	---	---	PASS
GPR15	2838	broad.mit.edu	37	3	98251656	98251656	+	Missense_Mutation	SNP	T	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr3:98251656T>G	uc011bgy.1	+	1	779	c.779T>G	c.(778-780)TTC>TGC	p.F260C		NM_005290	NP_005281	P49685	GPR15_HUMAN	G protein-coupled receptor 15	260	Helical; Name=6; (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)		TTCAATACTTTCAAGTTCCTG	0.458													35	64	---	---	---	---	PASS
ZBTB20	26137	broad.mit.edu	37	3	114070443	114070443	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr3:114070443C>A	uc003ebi.2	-	4	662	c.482G>T	c.(481-483)GGC>GTC	p.G161V	ZBTB20_uc003ebj.2_Missense_Mutation_p.G88V|ZBTB20_uc010hqp.2_Missense_Mutation_p.G88V|ZBTB20_uc003ebk.2_Missense_Mutation_p.G88V|ZBTB20_uc003ebl.2_Missense_Mutation_p.G88V|ZBTB20_uc003ebm.2_Missense_Mutation_p.G88V|ZBTB20_uc003ebn.2_Missense_Mutation_p.G88V|uc003ebo.1_5'Flank	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	161	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		CCGTAGCACGCCGCTGTACAT	0.562													42	35	---	---	---	---	PASS
IGSF11	152404	broad.mit.edu	37	3	118647366	118647366	+	Silent	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr3:118647366G>A	uc003ebw.2	-	3	661	c.414C>T	c.(412-414)CTC>CTT	p.L138L	IGSF11_uc011biv.1_Silent_p.L138L|IGSF11_uc003ebx.2_Silent_p.L138L|IGSF11_uc003eby.2_Silent_p.L137L|IGSF11_uc003ebz.2_Silent_p.L137L|IGSF11_uc010hqs.2_Silent_p.L137L	NM_001015887	NP_001015887	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11 isoform b	138	Extracellular (Potential).				cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity				0						CTAACACTGTGAGACCGGTGA	0.493													9	72	---	---	---	---	PASS
EPHB1	2047	broad.mit.edu	37	3	134670256	134670256	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr3:134670256G>T	uc003eqt.2	+	3	387	c.167G>T	c.(166-168)CGC>CTC	p.R56L	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_Missense_Mutation_p.R56L	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	56	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding	p.R56P(1)		lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						AACACCATCCGCACCTACCAG	0.517													14	16	---	---	---	---	PASS
GK5	256356	broad.mit.edu	37	3	141917686	141917686	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr3:141917686C>A	uc003euq.1	-	5	632	c.501G>T	c.(499-501)CAG>CAT	p.Q167H	GK5_uc010hus.1_RNA|GK5_uc010hut.1_RNA	NM_001039547	NP_001034636	Q6ZS86	GLPK5_HUMAN	glycerol kinase 5 (putative)	167					glycerol metabolic process		ATP binding|glycerol kinase activity				0						TCAAAGAAGTCTGCTGGGTTG	0.353													6	74	---	---	---	---	PASS
FAM194A	131831	broad.mit.edu	37	3	150377748	150377748	+	Silent	SNP	A	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr3:150377748A>C	uc003eyg.2	-	14	1980	c.1923T>G	c.(1921-1923)CTT>CTG	p.L641L	FAM194A_uc003eyh.2_Silent_p.L495L	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	hypothetical protein LOC131831	641										skin(2)|ovary(1)	3						AACTGTGACAAAGGGCAATTA	0.313													56	82	---	---	---	---	PASS
AADAC	13	broad.mit.edu	37	3	151535239	151535239	+	Missense_Mutation	SNP	C	T	T	rs150521396		TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr3:151535239C>T	uc003eze.2	+	2	314	c.224C>T	c.(223-225)TCA>TTA	p.S75L		NM_001086	NP_001077	P22760	AAAD_HUMAN	arylacetamide deacetylase	75	Lumenal (Potential).				positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			skin(2)	2		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			CCACCAACCTCAGATGAAAAT	0.413													18	78	---	---	---	---	PASS
ECT2	1894	broad.mit.edu	37	3	172537961	172537961	+	Silent	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr3:172537961C>T	uc003fii.2	+	24	2724	c.2586C>T	c.(2584-2586)GTC>GTT	p.V862V	ECT2_uc003fih.2_Silent_p.V861V|ECT2_uc003fij.1_Silent_p.V862V|ECT2_uc003fik.1_Silent_p.V862V|ECT2_uc003fil.1_Silent_p.V893V|ECT2_uc003fim.1_3'UTR	NM_018098	NP_060568	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	862					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|ovary(1)|skin(1)	4	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			CCTCCCTTGTCAGCCTTCCTT	0.318													17	155	---	---	---	---	PASS
PIK3CA	5290	broad.mit.edu	37	3	178928298	178928298	+	Missense_Mutation	SNP	A	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr3:178928298A>T	uc003fjk.2	+	9	1641	c.1484A>T	c.(1483-1485)CAT>CTT	p.H495L		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	495					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			ATTGAAGAGCATGCCAATTGG	0.418		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			39	63	---	---	---	---	PASS
RGS12	6002	broad.mit.edu	37	4	3422404	3422404	+	Missense_Mutation	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr4:3422404G>A	uc003ggw.2	+	10	3701	c.2797G>A	c.(2797-2799)GAG>AAG	p.E933K	RGS12_uc003ggv.2_Missense_Mutation_p.E933K|RGS12_uc003ggy.1_Missense_Mutation_p.E331K|RGS12_uc003ggz.2_Missense_Mutation_p.E285K|RGS12_uc010icu.1_Missense_Mutation_p.E132K|RGS12_uc011bvs.1_Missense_Mutation_p.E275K|RGS12_uc003gha.2_Missense_Mutation_p.E275K|RGS12_uc010icv.2_Missense_Mutation_p.E132K|RGS12_uc003ghb.2_Missense_Mutation_p.E132K	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	933						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GTGTCGCCGAGAGTCGCAGGG	0.602													9	59	---	---	---	---	PASS
DRD5	1816	broad.mit.edu	37	4	9783772	9783772	+	Missense_Mutation	SNP	A	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr4:9783772A>G	uc003gmb.3	+	1	515	c.119A>G	c.(118-120)CAG>CGG	p.Q40R		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	40	Helical; Name=1; (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	GGGCCCTCACAGGTGGTCACC	0.711													5	14	---	---	---	---	PASS
SLC2A9	56606	broad.mit.edu	37	4	9828172	9828172	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr4:9828172C>A	uc003gmc.2	-	12	1533	c.1472G>T	c.(1471-1473)GGT>GTT	p.G491V	SLC2A9_uc003gmd.2_Missense_Mutation_p.G462V	NM_020041	NP_064425	Q9NRM0	GTR9_HUMAN	solute carrier family 2, member 9 protein	491	Helical; Name=12; (Potential).				glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			ovary(3)	3						GTAGATAGCACCTGTGATACA	0.408													39	90	---	---	---	---	PASS
NKX3-2	579	broad.mit.edu	37	4	13544134	13544134	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr4:13544134G>T	uc003gmx.2	-	2	561	c.485C>A	c.(484-486)ACC>AAC	p.T162N		NM_001189	NP_001180	P78367	NKX32_HUMAN	NK3 homeobox 2	162					negative regulation of chondrocyte differentiation|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GTCGTCCTCGGTCCTTGGGCT	0.493													8	40	---	---	---	---	PASS
BOD1L	259282	broad.mit.edu	37	4	13616019	13616019	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr4:13616019C>A	uc003gmz.1	-	4	1092	c.975G>T	c.(973-975)AAG>AAT	p.K325N	BOD1L_uc010idr.1_5'UTR|BOD1L_uc010ids.1_RNA	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	325	Lys-rich.						DNA binding			ovary(5)|breast(1)	6						TGCTGTCTGGCTTCTTTTCAC	0.244													9	9	---	---	---	---	PASS
PCDH7	5099	broad.mit.edu	37	4	30921915	30921915	+	Silent	SNP	G	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr4:30921915G>C	uc011bxx.1	+	2	4323	c.3315G>C	c.(3313-3315)GCG>GCC	p.A1105A	PCDH7_uc011bxw.1_Silent_p.A1058A	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	Error:Variant_position_missing_in_O60245_after_alignment					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						GACTGGGTGCGCTTCCACTCC	0.542													16	61	---	---	---	---	PASS
C4orf7	260436	broad.mit.edu	37	4	71099810	71099810	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr4:71099810C>A	uc003hfd.2	+	4	249	c.164C>A	c.(163-165)CCA>CAA	p.P55Q		NM_152997	NP_694542	Q8NFU4	FDSCP_HUMAN	chromosome 4 open reading frame 7 precursor	55	Pro-rich.					extracellular region				central_nervous_system(1)	1						CCACTTCCACCAATTCCATTT	0.408													64	164	---	---	---	---	PASS
SHROOM3	57619	broad.mit.edu	37	4	77662456	77662456	+	Nonsense_Mutation	SNP	A	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr4:77662456A>T	uc011cbx.1	+	5	4083	c.3130A>T	c.(3130-3132)AGA>TGA	p.R1044*	SHROOM3_uc011cbz.1_Nonsense_Mutation_p.R868*|SHROOM3_uc003hkf.1_Nonsense_Mutation_p.R919*|SHROOM3_uc003hkg.2_Nonsense_Mutation_p.R822*	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	1044					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			GGGCCCGCAGAGAAATGGGAT	0.677													15	26	---	---	---	---	PASS
SPARCL1	8404	broad.mit.edu	37	4	88414957	88414957	+	Missense_Mutation	SNP	G	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr4:88414957G>C	uc010ikm.2	-	5	1567	c.995C>G	c.(994-996)CCC>CGC	p.P332R	SPARCL1_uc011cdc.1_Missense_Mutation_p.P207R|SPARCL1_uc003hqs.3_Missense_Mutation_p.P332R|SPARCL1_uc011cdd.1_Missense_Mutation_p.P207R|SPARCL1_uc003hqt.2_Missense_Mutation_p.P332R	NM_001128310	NP_001121782	Q14515	SPRL1_HUMAN	SPARC-like 1 precursor	332					signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.00118)		ATGATTTCTGGGCGTGGTATT	0.413													38	114	---	---	---	---	PASS
OSTC	58505	broad.mit.edu	37	4	109571833	109571833	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr4:109571833C>T	uc003hzb.1	+	1	93	c.22C>T	c.(22-24)CCG>TCG	p.P8S		NM_021227	NP_067050	Q9NRP0	OSTC_HUMAN	DC2 protein	8	Cytoplasmic (Potential).					integral to membrane|oligosaccharyltransferase complex				breast(1)	1						GTACCGTGTCCCGTTCTTAGT	0.597													34	66	---	---	---	---	PASS
ANK2	287	broad.mit.edu	37	4	114278280	114278280	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr4:114278280C>A	uc003ibe.3	+	38	8606	c.8506C>A	c.(8506-8508)CAA>AAA	p.Q2836K	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Missense_Mutation_p.Q138K|ANK2_uc011cgb.1_Missense_Mutation_p.Q2851K	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2803					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGAATCTCCACAAGCAGATTG	0.413													29	71	---	---	---	---	PASS
NDST4	64579	broad.mit.edu	37	4	115997762	115997762	+	Nonsense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr4:115997762G>T	uc003ibu.2	-	2	1110	c.431C>A	c.(430-432)TCA>TAA	p.S144*	NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	144	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		TCGATTCCATGAGTCCATGCT	0.358													22	54	---	---	---	---	PASS
ARHGAP10	79658	broad.mit.edu	37	4	148743893	148743893	+	Missense_Mutation	SNP	A	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr4:148743893A>T	uc003ilf.2	+	2	170	c.170A>T	c.(169-171)CAG>CTG	p.Q57L	ARHGAP10_uc003ile.1_Missense_Mutation_p.Q57L	NM_024605	NP_078881	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10	57	BAR.				apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			skin(2)|pancreas(1)|lung(1)	4	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		TCAGTGGCCCAGCGGAAGTTT	0.348													17	65	---	---	---	---	PASS
SPOCK3	50859	broad.mit.edu	37	4	167833819	167833819	+	Silent	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr4:167833819G>T	uc003iri.1	-	6	576	c.435C>A	c.(433-435)GTC>GTA	p.V145V	SPOCK3_uc011cjp.1_Silent_p.V142V|SPOCK3_uc011cjq.1_Silent_p.V154V|SPOCK3_uc011cjr.1_Silent_p.V25V|SPOCK3_uc003irj.1_Silent_p.V142V|SPOCK3_uc011cjs.1_Silent_p.V94V|SPOCK3_uc011cjt.1_Silent_p.V53V|SPOCK3_uc011cju.1_Silent_p.V38V|SPOCK3_uc011cjv.1_Intron|SPOCK3_uc003irk.3_Silent_p.V142V|SPOCK3_uc011cjw.1_Intron	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	145	Kazal-like.				signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		GGCTGGGATAGACCACTGGGC	0.428													11	48	---	---	---	---	PASS
ENPP6	133121	broad.mit.edu	37	4	185138911	185138911	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr4:185138911G>T	uc003iwc.2	-	1	204	c.62C>A	c.(61-63)TCT>TAT	p.S21Y		NM_153343	NP_699174	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	21					lipid catabolic process	extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)	1		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		CCGGCGGGCAGAGGCTGGCTG	0.617													11	30	---	---	---	---	PASS
DNAH5	1767	broad.mit.edu	37	5	13911575	13911575	+	Nonsense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr5:13911575C>A	uc003jfd.2	-	12	1606	c.1564G>T	c.(1564-1566)GAA>TAA	p.E522*	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	522	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AAATTGTATTCCTTTTTCTTT	0.299									Kartagener_syndrome				33	87	---	---	---	---	PASS
DNAH5	1767	broad.mit.edu	37	5	13911576	13911576	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr5:13911576C>A	uc003jfd.2	-	12	1605	c.1563G>T	c.(1561-1563)AAG>AAT	p.K521N	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	521	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AATTGTATTCCTTTTTCTTTA	0.303									Kartagener_syndrome				33	88	---	---	---	---	PASS
TRIO	7204	broad.mit.edu	37	5	14336720	14336720	+	Missense_Mutation	SNP	G	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr5:14336720G>C	uc003jff.2	+	11	1936	c.1930G>C	c.(1930-1932)GAG>CAG	p.E644Q	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Missense_Mutation_p.E595Q|TRIO_uc003jfh.1_Missense_Mutation_p.E293Q	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	644	Spectrin 2.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					TGACCCCGAAGAGATTTATCA	0.493													10	93	---	---	---	---	PASS
CDH10	1008	broad.mit.edu	37	5	24509761	24509761	+	Silent	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr5:24509761C>A	uc003jgr.1	-	7	1502	c.1170G>T	c.(1168-1170)CTG>CTT	p.L390L	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	390	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		GAACTTCAAACAGATAGGAGG	0.398										HNSCC(23;0.051)			13	56	---	---	---	---	PASS
PRLR	5618	broad.mit.edu	37	5	35065578	35065578	+	Silent	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr5:35065578C>A	uc003jjm.2	-	10	2012	c.1482G>T	c.(1480-1482)CTG>CTT	p.L494L	PRLR_uc003jjg.1_Intron|PRLR_uc003jjh.1_Intron|PRLR_uc003jji.1_Intron|PRLR_uc003jjj.1_Intron|PRLR_uc003jjk.1_Intron|PRLR_uc003jjl.3_Silent_p.L393L	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor	494	Cytoplasmic (Potential).				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TCTCCTGGGGCAGCAGCCAGG	0.493													23	141	---	---	---	---	PASS
FYB	2533	broad.mit.edu	37	5	39134313	39134313	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr5:39134313C>A	uc003jls.2	-	8	1881	c.1814G>T	c.(1813-1815)AGC>ATC	p.S605I	FYB_uc003jlt.2_Missense_Mutation_p.S605I|FYB_uc003jlu.2_Missense_Mutation_p.S605I|FYB_uc011cpl.1_Missense_Mutation_p.S615I	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	605					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			CACATACCTGCTAATATCATC	0.373													13	175	---	---	---	---	PASS
HTR1A	3350	broad.mit.edu	37	5	63256965	63256965	+	Silent	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr5:63256965G>T	uc011cqt.1	-	1	582	c.582C>A	c.(580-582)GGC>GGA	p.G194G		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	194	Helical; Name=5; (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	AGATAGTGTAGCCATGATCCT	0.582													52	165	---	---	---	---	PASS
CMYA5	202333	broad.mit.edu	37	5	79028312	79028312	+	Missense_Mutation	SNP	G	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr5:79028312G>C	uc003kgc.2	+	2	3796	c.3724G>C	c.(3724-3726)GTT>CTT	p.V1242L		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1242						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GAAATATTCAGTTTTGCCTGA	0.408													3	20	---	---	---	---	PASS
CMYA5	202333	broad.mit.edu	37	5	79029057	79029057	+	Missense_Mutation	SNP	G	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr5:79029057G>C	uc003kgc.2	+	2	4541	c.4469G>C	c.(4468-4470)AGG>ACG	p.R1490T		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1490						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GAGGAAGCAAGGGTAGAAGAC	0.388													27	138	---	---	---	---	PASS
CMYA5	202333	broad.mit.edu	37	5	79029058	79029058	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr5:79029058G>T	uc003kgc.2	+	2	4542	c.4470G>T	c.(4468-4470)AGG>AGT	p.R1490S		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1490						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AGGAAGCAAGGGTAGAAGACA	0.388													28	138	---	---	---	---	PASS
GPR98	84059	broad.mit.edu	37	5	89925282	89925282	+	Missense_Mutation	SNP	A	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr5:89925282A>G	uc003kju.2	+	9	1861	c.1765A>G	c.(1765-1767)AAA>GAA	p.K589E	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	589	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCCAGAGCAAAAAACTCAAGT	0.254													27	73	---	---	---	---	PASS
GPR98	84059	broad.mit.edu	37	5	89953949	89953949	+	Nonsense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr5:89953949G>T	uc003kju.2	+	21	4702	c.4606G>T	c.(4606-4608)GAA>TAA	p.E1536*	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1536	Calx-beta 10.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CAATGACGAGGAAGGAGAAGA	0.348													36	106	---	---	---	---	PASS
POU5F2	134187	broad.mit.edu	37	5	93077094	93077094	+	Missense_Mutation	SNP	T	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr5:93077094T>G	uc003kkl.1	-	1	216	c.176A>C	c.(175-177)GAC>GCC	p.D59A	FAM172A_uc010jbd.2_Intron|FAM172A_uc011cuf.1_Intron|FAM172A_uc011cug.1_Intron|FAM172A_uc011cuh.1_Intron|FAM172A_uc011cui.1_Intron|FAM172A_uc011cuj.1_Intron	NM_153216	NP_694948	Q8N7G0	PO5F2_HUMAN	POU domain class 5, transcription factor 2	59						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(142;3.87e-05)|all_epithelial(76;4.59e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0415)|all cancers(79;2.03e-19)		CCTCCACACGTCAGGGCCTGG	0.672													9	23	---	---	---	---	PASS
PCDHA1	56147	broad.mit.edu	37	5	140167301	140167301	+	Missense_Mutation	SNP	A	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr5:140167301A>T	uc003lhb.2	+	1	1426	c.1426A>T	c.(1426-1428)ACG>TCG	p.T476S	PCDHA1_uc003lha.2_Missense_Mutation_p.T476S|PCDHA1_uc003lgz.2_Missense_Mutation_p.T476S	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	476	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCACATCTTCACGGTGTCTGC	0.657													31	68	---	---	---	---	PASS
PCDHA1	56147	broad.mit.edu	37	5	140167302	140167302	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr5:140167302C>T	uc003lhb.2	+	1	1427	c.1427C>T	c.(1426-1428)ACG>ATG	p.T476M	PCDHA1_uc003lha.2_Missense_Mutation_p.T476M|PCDHA1_uc003lgz.2_Missense_Mutation_p.T476M	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	476	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACATCTTCACGGTGTCTGCG	0.652													32	67	---	---	---	---	PASS
PCDHA4	56144	broad.mit.edu	37	5	140186986	140186986	+	Missense_Mutation	SNP	G	A	A	rs3822351		TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr5:140186986G>A	uc003lhi.2	+	1	315	c.214G>A	c.(214-216)GGA>AGA	p.G72R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.G72R|PCDHA4_uc011daa.1_Missense_Mutation_p.G72R	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	72	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAAGGGCCGCGGAGGCCTTCT	0.652													60	143	---	---	---	---	PASS
PCDHB15	56121	broad.mit.edu	37	5	140625185	140625185	+	Missense_Mutation	SNP	A	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr5:140625185A>T	uc003lje.2	+	1	39	c.39A>T	c.(37-39)CAA>CAT	p.Q13H		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	13					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AACAAAGGCAAGTCCTGATTC	0.527													30	71	---	---	---	---	PASS
PCDHGA7	56108	broad.mit.edu	37	5	140762771	140762771	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr5:140762771G>T	uc003lka.1	+	1	305	c.305G>T	c.(304-306)TGT>TTT	p.C102F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Missense_Mutation_p.C102F	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	102	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTGCGCGGTGTCTGGTAAAC	0.483													36	62	---	---	---	---	PASS
PCDHGB7	56099	broad.mit.edu	37	5	140798237	140798237	+	Nonsense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr5:140798237G>T	uc003lkn.1	+	1	956	c.811G>T	c.(811-813)GAG>TAG	p.E271*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Nonsense_Mutation_p.E271*|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	271	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGACCAGGACGAGGGCATCAA	0.527													13	35	---	---	---	---	PASS
CANX	821	broad.mit.edu	37	5	179151779	179151779	+	Missense_Mutation	SNP	A	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr5:179151779A>T	uc003mkk.2	+	13	1817	c.1640A>T	c.(1639-1641)AAA>ATA	p.K547I	CANX_uc011dgp.1_Missense_Mutation_p.K582I|CANX_uc003mkl.2_Missense_Mutation_p.K547I|CANX_uc011dgq.1_Missense_Mutation_p.K439I	NM_001746	NP_001737	P27824	CALX_HUMAN	calnexin precursor	547	Cytoplasmic (Potential).				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein secretion	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane|melanosome	calcium ion binding|sugar binding|unfolded protein binding				0	all_cancers(89;0.000129)|all_epithelial(37;5.59e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0413)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	ggagaagagAAACTTGGTAAG	0.234													3	6	---	---	---	---	PASS
NUP153	9972	broad.mit.edu	37	6	17661915	17661915	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr6:17661915C>A	uc003ncd.1	-	11	1564	c.1364G>T	c.(1363-1365)CGC>CTC	p.R455L	NUP153_uc011dje.1_Missense_Mutation_p.R455L|NUP153_uc010jpl.1_Missense_Mutation_p.R455L	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	455				TR -> HA (in Ref. 1; CAA80982).	carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			AGCAACAAAGCGTGTTCTTTC	0.453													33	126	---	---	---	---	PASS
TRIM38	10475	broad.mit.edu	37	6	25973469	25973469	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr6:25973469C>T	uc003nfm.2	+	7	1265	c.830C>T	c.(829-831)TCC>TTC	p.S277F	TRIM38_uc003nfn.2_Missense_Mutation_p.S259F|TRIM38_uc010jqd.2_5'UTR	NM_006355	NP_006346	O00635	TRI38_HUMAN	tripartite motif-containing 38	277	B30.2/SPRY.				positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular	signal transducer activity|zinc ion binding				0						TGCAATGTTTCCAAGCTTTAC	0.418													11	31	---	---	---	---	PASS
TNXB	7148	broad.mit.edu	37	6	32047066	32047066	+	Silent	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr6:32047066C>A	uc003nzl.2	-	11	4321	c.4119G>T	c.(4117-4119)CCG>CCT	p.P1373P		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1460	Fibronectin type-III 7.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CCCCCAGGAGCGGCTCCTCGG	0.627													23	64	---	---	---	---	PASS
PPT2	9374	broad.mit.edu	37	6	32122917	32122917	+	Missense_Mutation	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr6:32122917G>A	uc003nzx.2	+	3	862	c.294G>A	c.(292-294)ATG>ATA	p.M98I	PRRT1_uc003nzu.2_5'Flank|uc003nzv.3_5'Flank|PPT2_uc003nzw.2_Missense_Mutation_p.M104I|PPT2_uc011dpi.1_Intron|PPT2_uc003nzy.1_RNA|PPT2_uc003nzz.2_Missense_Mutation_p.M98I|PPT2_uc003oaa.2_Missense_Mutation_p.M98I|PPT2_uc010jtu.1_Missense_Mutation_p.M98I	NM_005155	NP_005146	Q9UMR5	PPT2_HUMAN	palmitoyl-protein thioesterase 2 isoform a	98					protein modification process	lysosome	palmitoyl-(protein) hydrolase activity				0						TCCCCATCATGGCAAAGGCCC	0.582													7	64	---	---	---	---	PASS
LRFN2	57497	broad.mit.edu	37	6	40399870	40399870	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr6:40399870C>T	uc003oph.1	-	2	1448	c.983G>A	c.(982-984)CGC>CAC	p.R328H		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	328	Extracellular (Potential).|Ig-like.					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					CCCTACCAGGCGGTCATCGGG	0.582													10	62	---	---	---	---	PASS
CRISP2	7180	broad.mit.edu	37	6	49676896	49676896	+	Missense_Mutation	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr6:49676896G>A	uc003ozq.2	-	4	270	c.14C>T	c.(13-15)CCG>CTG	p.P5L	CRISP2_uc003ozl.2_Missense_Mutation_p.P5L|CRISP2_uc003ozn.2_Missense_Mutation_p.P5L|CRISP2_uc003ozr.2_Missense_Mutation_p.P5L|CRISP2_uc003ozo.2_Missense_Mutation_p.P5L|CRISP2_uc003ozm.2_Missense_Mutation_p.P5L|CRISP2_uc003ozp.2_Missense_Mutation_p.P5L	NM_001142408	NP_001135880	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2 precursor	5						extracellular space				skin(1)	1	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			AAACAACACCGGTAGTAAAGC	0.373													6	77	---	---	---	---	PASS
COL9A1	1297	broad.mit.edu	37	6	70964204	70964204	+	Missense_Mutation	SNP	C	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr6:70964204C>G	uc003pfg.3	-	25	1853	c.1694G>C	c.(1693-1695)GGT>GCT	p.G565A	COL9A1_uc003pfe.3_Missense_Mutation_p.G138A|COL9A1_uc003pff.3_Missense_Mutation_p.G322A	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	565	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						TCCTGCATCACCAGGAGGCCC	0.388													9	84	---	---	---	---	PASS
FILIP1	27145	broad.mit.edu	37	6	76022257	76022257	+	Silent	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr6:76022257C>T	uc003pia.2	-	5	3664	c.3291G>A	c.(3289-3291)GTG>GTA	p.V1097V	FILIP1_uc003phy.1_Silent_p.V1097V|FILIP1_uc003phz.2_Silent_p.V998V|FILIP1_uc010kbe.2_Silent_p.V1100V|FILIP1_uc003pib.1_Silent_p.V849V	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	1097										skin(3)|ovary(1)	4						TTTCGGCTGTCACGTTTACTG	0.507													22	131	---	---	---	---	PASS
HTR1E	3354	broad.mit.edu	37	6	87726078	87726078	+	Silent	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr6:87726078G>T	uc003pli.2	+	2	1729	c.1026G>T	c.(1024-1026)CTG>CTT	p.L342L		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	342	Helical; Name=7; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	TCAACCCTCTGCTCTATACGA	0.433													15	160	---	---	---	---	PASS
CDK19	23097	broad.mit.edu	37	6	110935789	110935789	+	Silent	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr6:110935789C>A	uc003puh.1	-	13	1531	c.1458G>T	c.(1456-1458)TCG>TCT	p.S486S	CDK19_uc003pui.1_Silent_p.S426S|CDK19_uc011eax.1_Silent_p.S362S	NM_015076	NP_055891	Q9BWU1	CDK19_HUMAN	cell division cycle 2-like 6 (CDK8-like)	486	Ser-rich.						ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						TCTGCTGAGACGAGGAAGAGT	0.592													25	62	---	---	---	---	PASS
DCBLD1	285761	broad.mit.edu	37	6	117859846	117859846	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr6:117859846C>T	uc003pxs.2	+	8	949	c.824C>T	c.(823-825)TCG>TTG	p.S275L	GOPC_uc003pxq.1_Intron|DCBLD1_uc003pxr.1_Missense_Mutation_p.S275L|DCBLD1_uc003pxt.1_5'Flank	NM_173674	NP_775945	Q8N8Z6	DCBD1_HUMAN	discoidin, CUB and LCCL domain containing 1	275	F5/8 type C.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(1)	1		all_cancers(87;0.171)		GBM - Glioblastoma multiforme(226;0.0447)|OV - Ovarian serous cystadenocarcinoma(136;0.0921)|all cancers(137;0.125)		TCATGGCAGTCGGTCAATGAG	0.502													21	135	---	---	---	---	PASS
L3MBTL3	84456	broad.mit.edu	37	6	130378581	130378581	+	Missense_Mutation	SNP	G	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr6:130378581G>C	uc003qbt.2	+	9	868	c.698G>C	c.(697-699)TGC>TCC	p.C233S	L3MBTL3_uc003qbu.2_Missense_Mutation_p.C208S	NM_032438	NP_115814	Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 isoform a	233	MBT 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		AAAGCGTGGTGCTGGGCATCC	0.527													7	26	---	---	---	---	PASS
SNX9	51429	broad.mit.edu	37	6	158318005	158318005	+	Silent	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr6:158318005C>A	uc003qqv.1	+	5	620	c.447C>A	c.(445-447)GGC>GGA	p.G149G		NM_016224	NP_057308	Q9Y5X1	SNX9_HUMAN	sorting nexin 9	149					cell communication|intracellular protein transport|lipid tube assembly|positive regulation of GTPase activity|positive regulation of protein oligomerization|receptor-mediated endocytosis	clathrin-coated vesicle|cytoplasmic vesicle membrane|extrinsic to internal side of plasma membrane|ruffle|trans-Golgi network	1-phosphatidylinositol binding|protein homodimerization activity|ubiquitin protein ligase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.167)		OV - Ovarian serous cystadenocarcinoma(65;8.06e-18)|BRCA - Breast invasive adenocarcinoma(81;4.48e-05)		CTGCCTTCGGCCACCCCCAGG	0.582													18	44	---	---	---	---	PASS
LPA	4018	broad.mit.edu	37	6	160998175	160998175	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr6:160998175G>T	uc003qtl.2	-	29	4744	c.4624C>A	c.(4624-4626)CCA>ACA	p.P1542T		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	4050	Kringle 36.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TACGCATTTGGGTAGTTTTCT	0.438													50	168	---	---	---	---	PASS
IQCE	23288	broad.mit.edu	37	7	2606780	2606780	+	Missense_Mutation	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:2606780G>A	uc003smo.3	+	2	251	c.67G>A	c.(67-69)GAC>AAC	p.D23N	IQCE_uc010ksm.1_Missense_Mutation_p.D23N|IQCE_uc003sml.1_Missense_Mutation_p.D23N|IQCE_uc011jvy.1_Intron|IQCE_uc011jvz.1_Intron|IQCE_uc003smk.3_Intron|IQCE_uc003smn.3_Intron	NM_152558	NP_689771	Q6IPM2	IQCE_HUMAN	IQ motif containing E isoform 1	23											0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)		AGTCACCTTTGACTCTGATGT	0.572													3	46	---	---	---	---	PASS
OCM	654231	broad.mit.edu	37	7	5920533	5920533	+	Missense_Mutation	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:5920533G>A	uc003spe.3	+	1	105	c.13G>A	c.(13-15)GAC>AAC	p.D5N		NM_001097622	NP_001091091	P0CE72	ONCO_HUMAN	oncomodulin	5							calcium ion binding				0		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0978)|OV - Ovarian serous cystadenocarcinoma(56;2.11e-14)		GAGCATCACGGACGTGCTCAG	0.547													15	86	---	---	---	---	PASS
GPNMB	10457	broad.mit.edu	37	7	23299746	23299746	+	Missense_Mutation	SNP	A	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:23299746A>T	uc003swc.2	+	5	850	c.689A>T	c.(688-690)TAC>TTC	p.Y230F	GPNMB_uc003swb.2_Missense_Mutation_p.Y230F|GPNMB_uc011jyy.1_Missense_Mutation_p.Y172F|GPNMB_uc011jyz.1_Missense_Mutation_p.Y131F	NM_001005340	NP_001005340	Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb isoform a	230	Extracellular (Potential).				negative regulation of cell proliferation	melanosome				ovary(3)|breast(2)	5			GBM - Glioblastoma multiforme(13;0.154)			AAAGATGTGTACGTGGTAACA	0.478													25	128	---	---	---	---	PASS
HOXA10	3206	broad.mit.edu	37	7	27213793	27213793	+	Missense_Mutation	SNP	C	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:27213793C>G	uc011jzm.1	-	1	163	c.133G>C	c.(133-135)GGT>CGT	p.G45R	HOXA10_uc003syw.3_Intron	NM_018951	NP_061824	P31260	HXA10_HUMAN	homeobox A10 isoform a	45	Poly-Gly.				spermatogenesis		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						ccaccaccaccgccgccTGCC	0.507													17	61	---	---	---	---	PASS
ADCYAP1R1	117	broad.mit.edu	37	7	31126607	31126607	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:31126607G>T	uc003tca.1	+	11	1097	c.874G>T	c.(874-876)GAT>TAT	p.D292Y	ADCYAP1R1_uc003tcb.1_Missense_Mutation_p.D271Y|ADCYAP1R1_uc003tcc.1_Missense_Mutation_p.D292Y|ADCYAP1R1_uc003tcd.1_Missense_Mutation_p.D292Y|ADCYAP1R1_uc003tce.1_Missense_Mutation_p.D292Y|ADCYAP1R1_uc003tcf.1_5'UTR	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	292	Extracellular (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			ovary(1)	1						ACTCTACTTTGATGACACAGG	0.507													25	167	---	---	---	---	PASS
GLI3	2737	broad.mit.edu	37	7	42007481	42007481	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:42007481C>A	uc011kbh.1	-	14	2235	c.2144G>T	c.(2143-2145)AGC>ATC	p.S715I	GLI3_uc011kbg.1_Missense_Mutation_p.S656I	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	715					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						GGACTGTTGGCTGCTGCATGA	0.542									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				23	209	---	---	---	---	PASS
IGFBP3	3486	broad.mit.edu	37	7	45956972	45956972	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:45956972G>T	uc003tns.2	-	2	602	c.470C>A	c.(469-471)ACG>AAG	p.T157K	IGFBP3_uc003tnq.2_RNA|IGFBP3_uc003tnr.2_Missense_Mutation_p.T163K|IGFBP3_uc003tnt.2_Missense_Mutation_p.T60K	NM_000598	NP_000589	P17936	IBP3_HUMAN	insulin-like growth factor binding protein 3	157	Ser/Thr-rich.				negative regulation of protein phosphorylation|negative regulation of signal transduction|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|positive regulation of apoptosis|positive regulation of myoblast differentiation|protein phosphorylation|regulation of cell growth	nucleus	insulin-like growth factor I binding|metal ion binding|protein tyrosine phosphatase activator activity			large_intestine(2)|lung(1)	3					Mecasermin(DB01277)	CACCCGGTGCGTGCTGGAGAC	0.532											OREG0018049	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	137	---	---	---	---	PASS
IKZF1	10320	broad.mit.edu	37	7	50468275	50468275	+	Missense_Mutation	SNP	G	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:50468275G>C	uc003tow.3	+	9	1678	c.1510G>C	c.(1510-1512)GAG>CAG	p.E504Q	IKZF1_uc003tox.3_Missense_Mutation_p.E462Q|IKZF1_uc003toy.3_Missense_Mutation_p.E462Q|IKZF1_uc011kck.1_Missense_Mutation_p.E417Q|IKZF1_uc003toz.3_Missense_Mutation_p.E474Q|IKZF1_uc010kyx.2_Missense_Mutation_p.E244Q|IKZF1_uc003tpa.3_Missense_Mutation_p.E246Q	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	504	C2H2-type 6.				cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.E504fs*?(1)		haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				GGACCGGTACGAGTTCTCGTC	0.612			D		ALL								11	137	---	---	---	---	PASS
EGFR	1956	broad.mit.edu	37	7	55259469	55259469	+	Missense_Mutation	SNP	G	T	T	rs146795390		TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:55259469G>T	uc003tqk.2	+	21	2773	c.2527G>T	c.(2527-2529)GTA>TTA	p.V843L	EGFR_uc010kzg.1_Missense_Mutation_p.V798L|EGFR_uc011kco.1_Missense_Mutation_p.V790L|uc003tqo.2_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	843	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V843I(6)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGCCAGGAACGTACTGGTGAA	0.537		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			198	88	---	---	---	---	PASS
EGFR	1956	broad.mit.edu	37	7	55259524	55259524	+	Missense_Mutation	SNP	T	A	A	rs121913444		TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:55259524T>A	uc003tqk.2	+	21	2828	c.2582T>A	c.(2581-2583)CTG>CAG	p.L861Q	EGFR_uc010kzg.1_Missense_Mutation_p.L816Q|EGFR_uc011kco.1_Missense_Mutation_p.L808Q|uc003tqo.2_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	861	Cytoplasmic (Potential).|Protein kinase.		L -> Q (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.L861Q(96)|p.L861R(10)|p.A859_L883>V(2)|p.L861F(1)|p.L861V(1)|p.L861P(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CTGGCCAAACTGCTGGGTGCG	0.557		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			174	98	---	---	---	---	PASS
ABCB4	5244	broad.mit.edu	37	7	87082427	87082427	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:87082427C>A	uc003uiv.1	-	6	445	c.369G>T	c.(367-369)TTG>TTT	p.L123F	ABCB4_uc003uiw.1_Missense_Mutation_p.L123F|ABCB4_uc003uix.1_Missense_Mutation_p.L123F|ABCB4_uc003uiy.2_Missense_Mutation_p.L123F	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	123	Helical; (By similarity).|ABC transmembrane type-1 1.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					CTCCAGCACCCAATCCTGAGT	0.308													25	71	---	---	---	---	PASS
ANKIB1	54467	broad.mit.edu	37	7	92019373	92019373	+	Silent	SNP	A	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:92019373A>T	uc003ulw.2	+	15	2371	c.1995A>T	c.(1993-1995)CCA>CCT	p.P665P	ANKIB1_uc010lew.1_5'UTR	NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	665							protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GTTCTTATCCATATGGATTTT	0.333													42	114	---	---	---	---	PASS
BRI3	25798	broad.mit.edu	37	7	97920546	97920546	+	Silent	SNP	C	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:97920546C>G	uc003upi.2	+	3	498	c.369C>G	c.(367-369)ACC>ACG	p.T123T	BRI3_uc011kip.1_Intron	NM_015379	NP_056194	O95415	BRI3_HUMAN	brain protein I3 isoform a	123						integral to membrane					0	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)					GTGGAGCCACCTTCGCTTAAA	0.473													28	70	---	---	---	---	PASS
MOSPD3	64598	broad.mit.edu	37	7	100210480	100210480	+	Silent	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:100210480G>T	uc003uvq.2	+	2	268	c.66G>T	c.(64-66)CGG>CGT	p.R22R	MOSPD3_uc003uvr.2_Silent_p.R22R|MOSPD3_uc003uvs.2_Silent_p.R22R|MOSPD3_uc003uvt.2_Silent_p.R22R	NM_001040097	NP_001035186	O75425	MSPD3_HUMAN	motile sperm domain containing 3 isoform a	22						integral to membrane	structural molecule activity			ovary(2)	2	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					gggggtcccggggcgccccTC	0.567													13	34	---	---	---	---	PASS
ZAN	7455	broad.mit.edu	37	7	100371097	100371097	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:100371097C>A	uc003uwj.2	+	30	5780	c.5615C>A	c.(5614-5616)CCA>CAA	p.P1872Q	ZAN_uc003uwk.2_Missense_Mutation_p.P1872Q|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_Missense_Mutation_p.P449Q|ZAN_uc011kke.1_5'Flank	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1872	VWFC 3.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGCACTGACCCAGCGGGCTCC	0.637													14	29	---	---	---	---	PASS
MUC17	140453	broad.mit.edu	37	7	100677549	100677549	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:100677549C>A	uc003uxp.1	+	3	2905	c.2852C>A	c.(2851-2853)ACC>AAC	p.T951N	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	951	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|13.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTGTTGACACCAGCACACCT	0.512													60	497	---	---	---	---	PASS
PIK3CG	5294	broad.mit.edu	37	7	106508804	106508804	+	Silent	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:106508804C>T	uc003vdv.3	+	2	883	c.798C>T	c.(796-798)AGC>AGT	p.S266S	PIK3CG_uc003vdu.2_Silent_p.S266S|PIK3CG_uc003vdw.2_Silent_p.S266S	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	266					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						AAAGCCAAAGCGAACAGGATT	0.552													13	67	---	---	---	---	PASS
FEZF1	389549	broad.mit.edu	37	7	121944015	121944015	+	Silent	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:121944015G>A	uc003vkd.2	-	1	551	c.477C>T	c.(475-477)GCC>GCT	p.A159A	FEZF1_uc003vkc.2_Intron|uc010lko.1_RNA|uc003vkf.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	159					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3						GGTAGCACAAGGCGCCCATGG	0.657													4	9	---	---	---	---	PASS
RNF148	378925	broad.mit.edu	37	7	122342126	122342126	+	Missense_Mutation	SNP	G	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:122342126G>C	uc003vkk.1	-	1	896	c.679C>G	c.(679-681)CAA>GAA	p.Q227E	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron|RNF133_uc003vkj.1_5'Flank|RNF148_uc010lkr.1_Nonsense_Mutation_p.S92*	NM_198085	NP_932351	Q8N7C7	RN148_HUMAN	ring finger protein 148 precursor	227						integral to membrane	zinc ion binding				0						GTCTTTATTTGACTTCGCCTC	0.428													9	51	---	---	---	---	PASS
FLNC	2318	broad.mit.edu	37	7	128480702	128480702	+	Silent	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:128480702G>T	uc003vnz.3	+	10	1859	c.1650G>T	c.(1648-1650)ACG>ACT	p.T550T	FLNC_uc003voa.3_Silent_p.T550T	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	550	Filamin 3.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						TGACCATCACGTGGGGCGGCT	0.647													59	91	---	---	---	---	PASS
CNOT4	4850	broad.mit.edu	37	7	135078671	135078671	+	Silent	SNP	T	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:135078671T>A	uc003vsv.1	-	10	1933	c.1626A>T	c.(1624-1626)GCA>GCT	p.A542A	CNOT4_uc003vss.2_Silent_p.A539A|CNOT4_uc011kpz.1_Silent_p.A539A|CNOT4_uc003vst.2_Silent_p.A542A|CNOT4_uc003vsu.1_Silent_p.A539A|CNOT4_uc011kpy.1_Silent_p.A542A	NM_001008225	NP_001008226	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	542					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding				0						TGAACCTACCTGCTACAGGGA	0.413													8	54	---	---	---	---	PASS
DGKI	9162	broad.mit.edu	37	7	137374731	137374731	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:137374731G>T	uc003vtt.2	-	2	420	c.419C>A	c.(418-420)GCA>GAA	p.A140E	DGKI_uc003vtu.2_Intron	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	140					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						CTGGAGGCCTGCCCGGGAGAT	0.468													8	80	---	---	---	---	PASS
JHDM1D	80853	broad.mit.edu	37	7	139793879	139793879	+	Missense_Mutation	SNP	C	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:139793879C>G	uc003vvm.2	-	18	2438	c.2434G>C	c.(2434-2436)GAT>CAT	p.D812H	JHDM1D_uc010lng.2_RNA	NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	812					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)					CTGGAAGTATCAAACTGTTTA	0.318													31	265	---	---	---	---	PASS
TAS2R60	338398	broad.mit.edu	37	7	143141210	143141210	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:143141210G>T	uc011ktg.1	+	1	665	c.665G>T	c.(664-666)AGA>ATA	p.R222I	uc003wda.2_Intron	NM_177437	NP_803186	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	222	Cytoplasmic (Potential).				sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			skin(6)	6	Melanoma(164;0.172)					TCTCTGGGAAGACACAGGAAG	0.463													49	114	---	---	---	---	PASS
ARHGEF35	445328	broad.mit.edu	37	7	143884332	143884332	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:143884332C>A	uc003wdz.1	-	2	1263	c.1145G>T	c.(1144-1146)TGG>TTG	p.W382L		NM_001003702	NP_001003702	A5YM69	ARG35_HUMAN	Rho guanine nucleotide exchange factor (GEF)	382	Glu-rich.										0						GCCCCCATCCCAACTCTCTGG	0.562													8	20	---	---	---	---	PASS
ZNF425	155054	broad.mit.edu	37	7	148802283	148802283	+	Missense_Mutation	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:148802283G>A	uc003wfj.2	-	4	753	c.680C>T	c.(679-681)TCC>TTC	p.S227F		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	227					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CTTCCCTCTGGACGAGTTTTT	0.527													4	85	---	---	---	---	PASS
NOS3	4846	broad.mit.edu	37	7	150698429	150698429	+	Silent	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:150698429C>A	uc003wif.2	+	11	1640	c.1344C>A	c.(1342-1344)ATC>ATA	p.I448I	NOS3_uc011kuy.1_Silent_p.I242I|NOS3_uc011kuz.1_Silent_p.I448I|NOS3_uc011kva.1_Silent_p.I448I|NOS3_uc011kvb.1_Silent_p.I448I	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	448	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	GGGCCTGGATCGTGCCCCCCA	0.622													28	79	---	---	---	---	PASS
MLL3	58508	broad.mit.edu	37	7	151842380	151842380	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr7:151842380G>T	uc003wla.2	-	54	14251	c.14032C>A	c.(14032-14034)CTT>ATT	p.L4678I	MLL3_uc003wkz.2_Missense_Mutation_p.L3796I|MLL3_uc003wkx.2_Missense_Mutation_p.L836I|MLL3_uc003wky.2_Missense_Mutation_p.L2242I	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	4678	FYR C-terminal.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ACCCCAGGAAGCTGAAAAGAA	0.488			N		medulloblastoma								3	69	---	---	---	---	PASS
DLC1	10395	broad.mit.edu	37	8	13259053	13259053	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr8:13259053G>T	uc003wwm.2	-	3	1543	c.1099C>A	c.(1099-1101)CAG>AAG	p.Q367K	DLC1_uc003wwn.2_Missense_Mutation_p.Q367K|DLC1_uc011kxy.1_Missense_Mutation_p.Q367K	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	367					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						TCTATGTCCTGATCAAGCTGG	0.493													17	65	---	---	---	---	PASS
ADAM2	2515	broad.mit.edu	37	8	39613369	39613369	+	Nonsense_Mutation	SNP	T	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr8:39613369T>A	uc003xnj.2	-	16	1750	c.1675A>T	c.(1675-1677)AGA>TGA	p.R559*	ADAM2_uc003xnk.2_Nonsense_Mutation_p.R540*|ADAM2_uc011lck.1_Intron|ADAM2_uc003xnl.2_Intron	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	559	Extracellular (Potential).|Cys-rich.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		ATAGTGGCTCTTGGAATTTGT	0.308													12	64	---	---	---	---	PASS
MRPL15	29088	broad.mit.edu	37	8	55060196	55060196	+	Missense_Mutation	SNP	G	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr8:55060196G>C	uc003xsa.2	+	5	871	c.808G>C	c.(808-810)GCT>CCT	p.A270P		NM_014175	NP_054894	Q9P015	RM15_HUMAN	mitochondrial ribosomal protein L15 precursor	270					translation	large ribosomal subunit|mitochondrion	structural constituent of ribosome				0		Lung NSC(129;0.109)|all_epithelial(80;0.134)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;4.3e-07)|Epithelial(17;5.79e-05)|all cancers(17;0.000458)			CTTTGGTCTTGCTCCAGGATG	0.403													15	67	---	---	---	---	PASS
RP1	6101	broad.mit.edu	37	8	55537694	55537694	+	Missense_Mutation	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr8:55537694G>A	uc003xsd.1	+	4	1400	c.1252G>A	c.(1252-1254)GAA>AAA	p.E418K	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	418					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TCAAGTGGCTGAAACTTGCAG	0.453													14	87	---	---	---	---	PASS
CHD7	55636	broad.mit.edu	37	8	61777948	61777948	+	Missense_Mutation	SNP	A	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr8:61777948A>T	uc003xue.2	+	38	8927	c.8450A>T	c.(8449-8451)AAT>ATT	p.N2817I		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2817					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GGGCTGTTGAATAACCCTCTG	0.557													4	15	---	---	---	---	PASS
ZFHX4	79776	broad.mit.edu	37	8	77690498	77690498	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr8:77690498G>T	uc003yav.2	+	4	3457	c.3070G>T	c.(3070-3072)GCC>TCC	p.A1024S	ZFHX4_uc003yau.1_Missense_Mutation_p.A1050S|ZFHX4_uc003yaw.1_Missense_Mutation_p.A1024S	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1024	C2H2-type 7.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTACTACTGTGCCGTGTGTGA	0.507										HNSCC(33;0.089)			49	136	---	---	---	---	PASS
ZFHX4	79776	broad.mit.edu	37	8	77764219	77764219	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr8:77764219C>A	uc003yav.2	+	10	5314	c.4927C>A	c.(4927-4929)CCA>ACA	p.P1643T	ZFHX4_uc003yau.1_Missense_Mutation_p.P1688T|ZFHX4_uc003yaw.1_Missense_Mutation_p.P1643T	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1643						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACATCACCCACCACAGTCACC	0.418										HNSCC(33;0.089)			18	70	---	---	---	---	PASS
NBN	4683	broad.mit.edu	37	8	90965859	90965859	+	Silent	SNP	A	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr8:90965859A>G	uc003yej.1	-	11	1568	c.1458T>C	c.(1456-1458)TCT>TCC	p.S486S	NBN_uc003yei.1_Silent_p.S404S|NBN_uc011lgb.1_Silent_p.S486S	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin	486					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)			AAAGAGAACAAGACGTTTCTA	0.353								Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				8	56	---	---	---	---	PASS
ESRP1	54845	broad.mit.edu	37	8	95677390	95677390	+	Missense_Mutation	SNP	A	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr8:95677390A>T	uc003ygq.3	+	9	1080	c.897A>T	c.(895-897)AAA>AAT	p.K299N	ESRP1_uc003ygr.3_Missense_Mutation_p.K299N|ESRP1_uc003ygs.3_Missense_Mutation_p.K299N|ESRP1_uc003ygt.3_Missense_Mutation_p.K299N|ESRP1_uc003ygu.3_Missense_Mutation_p.K299N|ESRP1_uc003ygv.2_Missense_Mutation_p.K139N|ESRP1_uc003ygw.2_Missense_Mutation_p.K139N	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	299	RRM 1.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						AGGTTTACAAAGCAACAGGTG	0.358													5	45	---	---	---	---	PASS
RIMS2	9699	broad.mit.edu	37	8	105010469	105010469	+	Missense_Mutation	SNP	G	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr8:105010469G>C	uc003yls.2	+	16	2676	c.2435G>C	c.(2434-2436)AGG>ACG	p.R812T	RIMS2_uc003ylp.2_Intron|RIMS2_uc003ylw.2_Missense_Mutation_p.R826T|RIMS2_uc003ylq.2_Missense_Mutation_p.R826T|RIMS2_uc003ylr.2_Intron	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1096					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CATCATCACAGGGATGGCAGG	0.358										HNSCC(12;0.0054)			36	84	---	---	---	---	PASS
CSMD3	114788	broad.mit.edu	37	8	113237021	113237021	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr8:113237021G>T	uc003ynu.2	-	71	11262	c.11103C>A	c.(11101-11103)AAC>AAA	p.N3701K	CSMD3_uc003yns.2_Missense_Mutation_p.N2903K|CSMD3_uc003ynt.2_Missense_Mutation_p.N3661K|CSMD3_uc011lhx.1_Missense_Mutation_p.N3532K	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3701	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGCAAACCGTGTTCAAGTTGG	0.423										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			45	136	---	---	---	---	PASS
CSMD3	114788	broad.mit.edu	37	8	113293558	113293558	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr8:113293558C>A	uc003ynu.2	-	59	9512	c.9353G>T	c.(9352-9354)GGA>GTA	p.G3118V	CSMD3_uc003yns.2_Missense_Mutation_p.G2320V|CSMD3_uc003ynt.2_Missense_Mutation_p.G3078V|CSMD3_uc011lhx.1_Missense_Mutation_p.G2949V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3118	Extracellular (Potential).|Sushi 23.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGCTGTGGTTCCTGGGTTACC	0.373										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			20	47	---	---	---	---	PASS
TRPS1	7227	broad.mit.edu	37	8	116617174	116617174	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr8:116617174C>T	uc003ynz.2	-	3	1442	c.983G>A	c.(982-984)GGG>GAG	p.G328E	TRPS1_uc011lhy.1_Missense_Mutation_p.G332E|TRPS1_uc003yny.2_Missense_Mutation_p.G341E|TRPS1_uc010mcy.2_Missense_Mutation_p.G328E	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	328					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			CTTGGTGTTCCCTTGGCAATC	0.408									Langer-Giedion_syndrome				26	80	---	---	---	---	PASS
TNFRSF11B	4982	broad.mit.edu	37	8	119941028	119941028	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr8:119941028G>T	uc003yon.3	-	3	864	c.541C>A	c.(541-543)CAC>AAC	p.H181N	TNFRSF11B_uc010mdc.1_RNA	NM_002546	NP_002537	O00300	TR11B_HUMAN	osteoprotegerin precursor	181	TNFR-Cys 4.				apoptosis|skeletal system development		cytokine activity|receptor activity			central_nervous_system(2)	2	all_cancers(13;3.71e-26)|Lung NSC(37;1.69e-07)|Ovarian(258;0.018)|all_neural(195;0.0592)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00193)			ATGTTGTCGTGTGTTGCATTT	0.383													27	151	---	---	---	---	PASS
ASAP1	50807	broad.mit.edu	37	8	131130758	131130758	+	Nonsense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr8:131130758C>A	uc003yta.1	-	18	1799	c.1771G>T	c.(1771-1773)GAA>TAA	p.E591*	ASAP1_uc003ysz.1_Nonsense_Mutation_p.E402*|ASAP1_uc011liw.1_Nonsense_Mutation_p.E584*	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	591					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						AGCAGTGGTTCCATTAGCTCT	0.373													17	107	---	---	---	---	PASS
FAM135B	51059	broad.mit.edu	37	8	139163751	139163751	+	Silent	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr8:139163751C>A	uc003yuy.2	-	13	3138	c.2967G>T	c.(2965-2967)GTG>GTT	p.V989V	FAM135B_uc003yux.2_Silent_p.V890V|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Silent_p.V551V|FAM135B_uc003yvb.2_Silent_p.V551V	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	989										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CGGAATGGGTCACAGTGGGGC	0.493										HNSCC(54;0.14)			7	103	---	---	---	---	PASS
SLC1A1	6505	broad.mit.edu	37	9	4567684	4567684	+	Missense_Mutation	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr9:4567684G>A	uc003zij.1	+	6	735	c.499G>A	c.(499-501)GAA>AAA	p.E167K	C9orf68_uc003zik.2_Intron	NM_004170	NP_004161	P43005	EAA3_HUMAN	solute carrier family 1, member 1	167	Extracellular (Potential).				D-aspartate import|L-glutamate import|synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity				0		Acute lymphoblastic leukemia(2;0.0359)|Breast(48;0.0457)		GBM - Glioblastoma multiforme(50;0.0124)|Lung(218;0.183)	L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)	AACTAAGCGTGAAGAAGTGAA	0.383													13	39	---	---	---	---	PASS
KIAA2026	158358	broad.mit.edu	37	9	5922375	5922375	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr9:5922375C>A	uc003zjq.3	-	8	3837	c.3621G>T	c.(3619-3621)GAG>GAT	p.E1207D	KIAA2026_uc010mht.2_Missense_Mutation_p.E382D	NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	1207										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		CTTTTCCTGCCTCACTCTGGC	0.458													16	79	---	---	---	---	PASS
CTSL1	1514	broad.mit.edu	37	9	90343291	90343291	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr9:90343291G>T	uc004aph.2	+	4	726	c.376G>T	c.(376-378)GTG>TTG	p.V126L	CTSL1_uc004api.2_Missense_Mutation_p.V126L|CTSL1_uc004apj.2_Missense_Mutation_p.V71L|CTSL1_uc010mqh.2_Intron|CTSL1_uc004apk.2_Missense_Mutation_p.V126L|CTSL1_uc004apl.2_Missense_Mutation_p.V126L	NM_001912	NP_001903	P07711	CATL1_HUMAN	cathepsin L1 preproprotein	126					macrophage apoptosis|proteolysis	extracellular region|lysosome|nucleus	cysteine-type endopeptidase activity|histone binding			ovary(3)	3					Glucagon recombinant(DB00040)	GAAAGGCTACGTGACTCCTGT	0.478													13	34	---	---	---	---	PASS
ACTL7A	10881	broad.mit.edu	37	9	111625376	111625376	+	Missense_Mutation	SNP	C	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr9:111625376C>G	uc004bdj.1	+	1	774	c.774C>G	c.(772-774)AAC>AAG	p.N258K		NM_006687	NP_006678	Q9Y615	ACL7A_HUMAN	actin-like 7A	258						cytoplasm|cytoskeleton|protein complex	structural constituent of cytoskeleton				0						GCCTGCTGAACAGTGCGGGGA	0.572													7	38	---	---	---	---	PASS
FKBP15	23307	broad.mit.edu	37	9	115952794	115952794	+	Missense_Mutation	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr9:115952794G>A	uc004bgs.2	-	12	1248	c.1130C>T	c.(1129-1131)CCC>CTC	p.P377L	FKBP15_uc010muu.1_Missense_Mutation_p.P441L|FKBP15_uc011lxc.1_5'Flank|FKBP15_uc011lxd.1_Missense_Mutation_p.P309L|FKBP15_uc010mut.1_Missense_Mutation_p.P245L|FKBP15_uc004bgt.2_Missense_Mutation_p.P377L	NM_015258	NP_056073	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	377					endocytosis|protein folding	axon|early endosome	actin binding			ovary(3)	3						TGGAAGGATGGGCAGCATGGG	0.453													6	18	---	---	---	---	PASS
CERCAM	51148	broad.mit.edu	37	9	131186890	131186890	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr9:131186890G>T	uc004buz.3	+	5	1161	c.763G>T	c.(763-765)GCT>TCT	p.A255S	CERCAM_uc004buy.1_Missense_Mutation_p.A177S|CERCAM_uc010mxz.2_Missense_Mutation_p.A177S|CERCAM_uc010mya.1_Missense_Mutation_p.A96S	NM_016174	NP_057258	Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule 1	255					cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				pancreas(1)	1						CTGCCAGGCTGCTGGTGAGGA	0.403													23	57	---	---	---	---	PASS
USP20	10868	broad.mit.edu	37	9	132642449	132642449	+	Missense_Mutation	SNP	G	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr9:132642449G>C	uc004bys.2	+	25	2853	c.2642G>C	c.(2641-2643)GGA>GCA	p.G881A	USP20_uc004byr.2_Missense_Mutation_p.G881A|USP20_uc004byt.1_Missense_Mutation_p.G881A|USP20_uc004byu.1_Missense_Mutation_p.G67A	NM_001110303	NP_001103773	Q9Y2K6	UBP20_HUMAN	ubiquitin specific protease 20	881	DUSP 2.				endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			lung(1)|breast(1)	2		Ovarian(14;0.00556)				AGCCTGTATGGAGGTGGCCCC	0.647													5	67	---	---	---	---	PASS
FUBP3	8939	broad.mit.edu	37	9	133488374	133488374	+	Silent	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr9:133488374G>T	uc004bzr.1	+	5	414	c.306G>T	c.(304-306)CGG>CGT	p.R102R	FUBP3_uc010mzd.1_Silent_p.R42R|FUBP3_uc004bzs.1_Silent_p.R15R	NM_003934	NP_003925	Q96I24	FUBP3_HUMAN	far upstream element (FUSE) binding protein 3	102	KH 1.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|RNA binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;0.000279)		AGATTTCACGGATTCAAGCAG	0.388													7	58	---	---	---	---	PASS
FUBP3	8939	broad.mit.edu	37	9	133501800	133501800	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr9:133501800G>T	uc004bzr.1	+	12	1133	c.1025G>T	c.(1024-1026)GGC>GTC	p.G342V	FUBP3_uc004bzs.1_Missense_Mutation_p.G255V	NM_003934	NP_003925	Q96I24	FUBP3_HUMAN	far upstream element (FUSE) binding protein 3	342					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|RNA binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;0.000279)		AGAGGTCGTGGCCGTGGCGAC	0.607											OREG0019546	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	24	---	---	---	---	PASS
LAMC3	10319	broad.mit.edu	37	9	133901760	133901760	+	Missense_Mutation	SNP	C	A	A	rs147423784		TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr9:133901760C>A	uc004caa.1	+	2	560	c.462C>A	c.(460-462)GAC>GAA	p.D154E		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	154	Laminin N-terminal.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		GCCGCGCCGACGGCCCATGGG	0.652													8	69	---	---	---	---	PASS
ITIH5	80760	broad.mit.edu	37	10	7683937	7683937	+	Silent	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr10:7683937C>T	uc001ijq.2	-	3	331	c.252G>A	c.(250-252)GAG>GAA	p.E84E	ITIH5_uc001ijr.1_Silent_p.E84E	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	84	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						GCATCTGGAACTCAATGTCCT	0.478													15	77	---	---	---	---	PASS
GPR158	57512	broad.mit.edu	37	10	25684912	25684912	+	Missense_Mutation	SNP	C	A	A	rs145500194		TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr10:25684912C>A	uc001isj.2	+	3	1141	c.1081C>A	c.(1081-1083)CCT>ACT	p.P361T		NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	361	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						ATTCTATCATCCTGGAGTCTT	0.358													7	30	---	---	---	---	PASS
GAD2	2572	broad.mit.edu	37	10	26559583	26559583	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr10:26559583C>A	uc001isp.2	+	10	1493	c.990C>A	c.(988-990)TTC>TTA	p.F330L	GAD2_uc001isq.2_Missense_Mutation_p.F330L	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	330					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	TTGTTCCTTTCCTCGTGAGTG	0.463													29	179	---	---	---	---	PASS
ZNF33A	7581	broad.mit.edu	37	10	38344909	38344909	+	Nonsense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr10:38344909C>A	uc001izh.2	+	5	2032	c.1854C>A	c.(1852-1854)TAC>TAA	p.Y618*	ZNF33A_uc001izg.2_Nonsense_Mutation_p.Y619*|ZNF33A_uc010qev.1_Nonsense_Mutation_p.Y625*|ZNF33A_uc001izi.1_Intron	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	618	C2H2-type 11.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						AAGCCTTCTACCAGAAGTCAC	0.368													10	86	---	---	---	---	PASS
PRKG1	5592	broad.mit.edu	37	10	54031115	54031115	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr10:54031115G>T	uc001jjm.2	+	11	1328	c.1134G>T	c.(1132-1134)CAG>CAT	p.Q378H	PRKG1_uc001jjo.2_Missense_Mutation_p.Q393H|PRKG1_uc009xow.1_Missense_Mutation_p.Q96H|uc001jjq.1_Intron	NM_001098512	NP_001091982	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I isoform	378	Protein kinase.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			lung(2)|stomach(1)|ovary(1)|central_nervous_system(1)|skin(1)	6		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		TTAAGGTCCAGTTGAAAAGTG	0.408													13	38	---	---	---	---	PASS
CTNNA3	29119	broad.mit.edu	37	10	68139060	68139060	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr10:68139060G>T	uc009xpn.1	-	12	1705	c.1582C>A	c.(1582-1584)CAG>AAG	p.Q528K	CTNNA3_uc001jmw.2_Missense_Mutation_p.Q528K	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	528					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						TCAGCATCCTGGTCTCTTAAG	0.443													16	115	---	---	---	---	PASS
PDZD7	79955	broad.mit.edu	37	10	102782143	102782143	+	Splice_Site	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr10:102782143C>A	uc001kso.1	-	5	758	c.543_splice	c.e5-1	p.W181_splice	PDZD7_uc001ksn.2_Splice_Site_p.W181_splice	NM_024895	NP_079171	Q9H5P4	PDZD7_HUMAN	PDZ domain containing 7							cilium|nucleus	protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3				Epithelial(162;6.98e-09)|all cancers(201;3.55e-07)		CACATCCACCCTGGACAACAG	0.612													11	23	---	---	---	---	PASS
ABLIM1	3983	broad.mit.edu	37	10	116335269	116335269	+	Missense_Mutation	SNP	G	A	A	rs147888427		TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr10:116335269G>A	uc010qsg.1	-	3	568	c.469C>T	c.(469-471)CGC>TGC	p.R157C	ABLIM1_uc010qsh.1_Missense_Mutation_p.R97C|ABLIM1_uc010qsi.1_Missense_Mutation_p.R97C|ABLIM1_uc010qsk.1_Missense_Mutation_p.R81C|ABLIM1_uc009xyp.2_Missense_Mutation_p.R91C|ABLIM1_uc009xyo.2_Missense_Mutation_p.R5C	NM_002313	NP_002304	O14639	ABLM1_HUMAN	actin-binding LIM protein 1 isoform a	157	LIM zinc-binding 2.				axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(1)	1		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		CCATGGCAGCGTGTCCCGTAC	0.542													16	90	---	---	---	---	PASS
VENTX	27287	broad.mit.edu	37	10	135053746	135053746	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr10:135053746G>T	uc010quy.1	+	3	724	c.713G>T	c.(712-714)GGA>GTA	p.G238V		NM_014468	NP_055283	O95231	VENTX_HUMAN	VENT homeobox	238					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(35;4.15e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.8e-06)|Epithelial(32;9.31e-06)|all cancers(32;1.19e-05)		CCTTCGCTGGGACCAGCCCTG	0.682													7	20	---	---	---	---	PASS
TUBGCP2	10844	broad.mit.edu	37	10	135095829	135095829	+	Missense_Mutation	SNP	C	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr10:135095829C>G	uc001lmg.1	-	16	2664	c.2307G>C	c.(2305-2307)ATG>ATC	p.M769I	TUBGCP2_uc001lmf.1_Missense_Mutation_p.M362I|TUBGCP2_uc010qvc.1_Missense_Mutation_p.M797I|TUBGCP2_uc009ybk.1_Missense_Mutation_p.M792I|TUBGCP2_uc010qvd.1_Missense_Mutation_p.M639I|TUBGCP2_uc001lmh.1_RNA	NM_006659	NP_006650	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	769					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		CATCTAATTTCATGCTCTGTG	0.582													8	25	---	---	---	---	PASS
TNNT3	7140	broad.mit.edu	37	11	1950353	1950353	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr11:1950353C>A	uc001luu.3	+	7	298	c.86C>A	c.(85-87)ACC>AAC	p.T29N	TNNT3_uc001lun.2_Intron|TNNT3_uc001luw.3_Intron|TNNT3_uc001luo.3_Intron|TNNT3_uc001lup.3_Intron|TNNT3_uc001luq.3_Intron|TNNT3_uc001lur.2_Intron|TNNT3_uc010qxf.1_Intron|TNNT3_uc010qxg.1_Intron|TNNT3_uc001lut.1_RNA|TNNT3_uc001lus.1_Intron	NM_006757	NP_006748	P45378	TNNT3_HUMAN	troponin T3, skeletal, fast isoform 1	40					muscle filament sliding|regulation of ATPase activity|regulation of striated muscle contraction|skeletal muscle contraction	cytosol|troponin complex	calcium-dependent protein binding|tropomyosin binding|troponin C binding|troponin I binding			ovary(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00253)|Lung(200;0.0333)|LUSC - Lung squamous cell carcinoma(625;0.0826)		CTGGAAGACACCGCAGAGGAG	0.672													36	120	---	---	---	---	PASS
ARNTL	406	broad.mit.edu	37	11	13397284	13397284	+	Missense_Mutation	SNP	A	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr11:13397284A>G	uc001mkr.2	+	15	1708	c.1300A>G	c.(1300-1302)ATT>GTT	p.I434V	ARNTL_uc001mko.2_Missense_Mutation_p.I390V|ARNTL_uc001mkp.2_Missense_Mutation_p.I433V|ARNTL_uc001mkq.2_Missense_Mutation_p.I433V|ARNTL_uc001mks.2_Missense_Mutation_p.I391V|ARNTL_uc001mkt.2_Missense_Mutation_p.I434V|ARNTL_uc001mku.2_RNA|ARNTL_uc009ygm.1_Missense_Mutation_p.I273V|ARNTL_uc001mkw.2_Missense_Mutation_p.I391V|ARNTL_uc001mkx.2_Missense_Mutation_p.I432V|ARNTL_uc001mky.2_Translation_Start_Site	NM_001178	NP_001169	O00327	BMAL1_HUMAN	aryl hydrocarbon receptor nuclear	434	PAC.				circadian rhythm|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	aryl hydrocarbon receptor binding|DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity				0				Epithelial(150;0.0243)		AGTAGAATATATTGTCTCAAC	0.383													8	31	---	---	---	---	PASS
OR8I2	120586	broad.mit.edu	37	11	55861580	55861580	+	Nonsense_Mutation	SNP	C	A	A	rs116327084	byFrequency	TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr11:55861580C>A	uc010rix.1	+	1	797	c.797C>A	c.(796-798)TCG>TAG	p.S266*		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	266	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					AACACATCATCGCTGACCCAG	0.463													27	80	---	---	---	---	PASS
YPEL4	219539	broad.mit.edu	37	11	57413813	57413813	+	Missense_Mutation	SNP	T	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr11:57413813T>A	uc001nkv.3	-	4	695	c.251A>T	c.(250-252)GAC>GTC	p.D84V	uc001nkt.1_Intron|YPEL4_uc009ymk.2_RNA	NM_145008	NP_659445	Q96NS1	YPEL4_HUMAN	yippee-like 4	84						nucleolus					0						ACAGAAAATGTCAGCTACCGA	0.562													7	88	---	---	---	---	PASS
OR6Q1	219952	broad.mit.edu	37	11	57799282	57799282	+	Silent	SNP	G	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr11:57799282G>C	uc010rjz.1	+	1	858	c.858G>C	c.(856-858)ACG>ACC	p.T286T	OR9Q1_uc001nmj.2_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	286	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)				CTGTTGTCACGCCCATGCTCA	0.473													25	193	---	---	---	---	PASS
EML3	256364	broad.mit.edu	37	11	62376917	62376917	+	Missense_Mutation	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr11:62376917G>A	uc001ntu.1	-	6	975	c.667C>T	c.(667-669)CGC>TGC	p.R223C	EML3_uc001ntr.1_Missense_Mutation_p.R195C|EML3_uc001nts.1_Missense_Mutation_p.R195C|EML3_uc001ntt.1_Missense_Mutation_p.R107C|EML3_uc010rly.1_Missense_Mutation_p.R223C|EML3_uc009yny.1_Missense_Mutation_p.R6C	NM_153265	NP_694997	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like	223						cytoplasm|microtubule	protein binding			ovary(1)	1						GTAATGGGGCGCCCTCGAAGG	0.582													21	104	---	---	---	---	PASS
HNRNPUL2	221092	broad.mit.edu	37	11	62487535	62487535	+	Silent	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr11:62487535C>T	uc001nuw.2	-	10	1933	c.1740G>A	c.(1738-1740)GAG>GAA	p.E580E	HNRNPUL2_uc001nuu.1_RNA	NM_001079559	NP_001073027	Q1KMD3	HNRL2_HUMAN	heterogeneous nuclear ribonucleoprotein U-like	580					cell killing	nucleus	ATP binding|nucleic acid binding				0						CATCATCTCCCTCTACTTCCT	0.348													6	224	---	---	---	---	PASS
IGHMBP2	3508	broad.mit.edu	37	11	68675734	68675734	+	Missense_Mutation	SNP	G	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr11:68675734G>C	uc001ook.1	+	3	480	c.378G>C	c.(376-378)TTG>TTC	p.L126F	IGHMBP2_uc001ooj.1_RNA	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	126					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			ATTTCCAGTTGAGCTTGGACC	0.502													21	117	---	---	---	---	PASS
IGHMBP2	3508	broad.mit.edu	37	11	68705714	68705714	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr11:68705714G>T	uc001ook.1	+	14	2778	c.2676G>T	c.(2674-2676)AAG>AAT	p.K892N	IGHMBP2_uc001ool.1_Missense_Mutation_p.K516N	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	892					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CCGCCGTTAAGGCTGATAACA	0.627													26	72	---	---	---	---	PASS
P2RY2	5029	broad.mit.edu	37	11	72946147	72946147	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr11:72946147C>T	uc001otj.2	+	3	1276	c.943C>T	c.(943-945)CGC>TGC	p.R315C	P2RY2_uc001otk.2_Missense_Mutation_p.R315C|P2RY2_uc001otl.2_Missense_Mutation_p.R315C	NM_002564	NP_002555	P41231	P2RY2_HUMAN	purinergic receptor P2Y2	315	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(1)|skin(1)	4					Suramin(DB04786)	GAGGCTCGTACGCTTTGCCCG	0.647													9	48	---	---	---	---	PASS
P2RY6	5031	broad.mit.edu	37	11	73007682	73007682	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr11:73007682G>T	uc001otm.2	+	4	524	c.119G>T	c.(118-120)GGC>GTC	p.G40V	P2RY6_uc001otn.2_Missense_Mutation_p.G40V|P2RY6_uc001oto.2_Missense_Mutation_p.G40V|P2RY6_uc001otp.2_Missense_Mutation_p.G40V|P2RY6_uc001otq.2_Missense_Mutation_p.G40V|P2RY6_uc001otr.2_Missense_Mutation_p.G40V|P2RY6_uc001ots.2_Missense_Mutation_p.G40V	NM_176796	NP_789766	Q15077	P2RY6_HUMAN	pyrimidinergic receptor P2Y6	40	Helical; Name=1; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1						CTGGCGGCTGGCCTGCCGCTG	0.632													70	180	---	---	---	---	PASS
DNAJB13	374407	broad.mit.edu	37	11	73681140	73681140	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr11:73681140G>T	uc001ouo.2	+	8	1683	c.932G>T	c.(931-933)CGC>CTC	p.R311L		NM_153614	NP_705842	P59910	DJB13_HUMAN	testis spermatogenesis apoptosis-related protein	311					apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding				0	Breast(11;7.42e-05)					CAGATGCTGCGCCAGGCATTG	0.617													23	108	---	---	---	---	PASS
CNTN5	53942	broad.mit.edu	37	11	99715950	99715950	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr11:99715950C>A	uc001pga.2	+	6	872	c.533C>A	c.(532-534)ACT>AAT	p.T178N	CNTN5_uc009ywv.1_Missense_Mutation_p.T178N|CNTN5_uc001pfz.2_Missense_Mutation_p.T178N|CNTN5_uc001pgb.2_Missense_Mutation_p.T104N	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	178	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GCAACCAACACTGTGGGGAGT	0.348													24	189	---	---	---	---	PASS
MMP1	4312	broad.mit.edu	37	11	102665947	102665947	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr11:102665947G>T	uc001phi.2	-	6	1000	c.857C>A	c.(856-858)GCT>GAT	p.A286D	uc001phh.1_RNA|MMP1_uc010ruv.1_Missense_Mutation_p.A220D	NM_002421	NP_002412	P03956	MMP1_HUMAN	matrix metalloproteinase 1 isoform 1	286	Hemopexin-like 1.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)|lung(1)	4	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		CGTAGTTATAGCATCAAAGGT	0.408													14	102	---	---	---	---	PASS
OR6M1	390261	broad.mit.edu	37	11	123676798	123676798	+	Missense_Mutation	SNP	T	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr11:123676798T>G	uc010rzz.1	-	1	260	c.260A>C	c.(259-261)GAG>GCG	p.E87A		NM_001005325	NP_001005325	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M,	87	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		TATGGTTTTCTCTTCTCCTAG	0.438													9	59	---	---	---	---	PASS
CACNA1C	775	broad.mit.edu	37	12	2693738	2693738	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr12:2693738C>A	uc009zdu.1	+	16	2607	c.2294C>A	c.(2293-2295)GCC>GAC	p.A765D	CACNA1C_uc009zdv.1_Missense_Mutation_p.A762D|CACNA1C_uc001qkb.2_Missense_Mutation_p.A765D|CACNA1C_uc001qkc.2_Missense_Mutation_p.A765D|CACNA1C_uc001qke.2_Missense_Mutation_p.A765D|CACNA1C_uc001qkf.2_Missense_Mutation_p.A765D|CACNA1C_uc001qjz.2_Missense_Mutation_p.A765D|CACNA1C_uc001qkd.2_Missense_Mutation_p.A765D|CACNA1C_uc001qkg.2_Missense_Mutation_p.A765D|CACNA1C_uc009zdw.1_Missense_Mutation_p.A765D|CACNA1C_uc001qkh.2_Missense_Mutation_p.A765D|CACNA1C_uc001qkl.2_Missense_Mutation_p.A765D|CACNA1C_uc001qkn.2_Missense_Mutation_p.A765D|CACNA1C_uc001qko.2_Missense_Mutation_p.A765D|CACNA1C_uc001qkp.2_Missense_Mutation_p.A765D|CACNA1C_uc001qkr.2_Missense_Mutation_p.A765D|CACNA1C_uc001qku.2_Missense_Mutation_p.A765D|CACNA1C_uc001qkq.2_Missense_Mutation_p.A765D|CACNA1C_uc001qks.2_Missense_Mutation_p.A765D|CACNA1C_uc001qkt.2_Missense_Mutation_p.A765D|CACNA1C_uc001qka.1_Missense_Mutation_p.A300D|CACNA1C_uc001qki.1_Missense_Mutation_p.A501D|CACNA1C_uc001qkj.1_Missense_Mutation_p.A501D|CACNA1C_uc001qkk.1_Missense_Mutation_p.A501D|CACNA1C_uc001qkm.1_Missense_Mutation_p.A501D|CACNA1C_uc001qkw.2_Missense_Mutation_p.A54D	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	765	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CTCACATCTGCCCaaaaggag	0.433													24	33	---	---	---	---	PASS
APOBEC1	339	broad.mit.edu	37	12	7805379	7805379	+	Missense_Mutation	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr12:7805379G>A	uc001qtb.2	-	3	131	c.97C>T	c.(97-99)CGT>TGT	p.R33C	APOBEC1_uc001qtc.2_5'UTR|APOBEC1_uc010sgf.1_Missense_Mutation_p.R33C	NM_001644	NP_001635	P41238	ABEC1_HUMAN	apolipoprotein B mRNA editing enzyme	33					cytidine to uridine editing|DNA demethylation|lipid metabolic process|mRNA modification|mRNA processing|negative regulation of methylation-dependent chromatin silencing	nucleoplasm	cytidine deaminase activity|RNA binding|zinc ion binding				0						GCCTCTTTACGAAGTTCTCTG	0.473													16	93	---	---	---	---	PASS
KLRC3	3823	broad.mit.edu	37	12	10568344	10568344	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr12:10568344G>T	uc001qyf.2	-	6	682	c.637C>A	c.(637-639)CGT>AGT	p.R213S	KLRC3_uc001qyh.2_Missense_Mutation_p.R213S|KLRC3_uc001qyi.1_Missense_Mutation_p.R213S	NM_002261	NP_002252	Q07444	NKG2E_HUMAN	killer cell lectin-like receptor subfamily C,	213	C-type lectin.|Extracellular (Potential).				cellular defense response	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|skin(1)	3						ATAAGTCCACGTACATGTAGC	0.363													36	42	---	---	---	---	PASS
PDZRN4	29951	broad.mit.edu	37	12	41967075	41967075	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr12:41967075C>T	uc010skn.1	+	10	1965	c.1897C>T	c.(1897-1899)CCT>TCT	p.P633S	PDZRN4_uc001rmq.3_Missense_Mutation_p.P574S|PDZRN4_uc009zjz.2_Missense_Mutation_p.P572S|PDZRN4_uc001rmr.2_Missense_Mutation_p.P459S	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	832							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TTACCTCTCTCCTTACCACAG	0.468													45	122	---	---	---	---	PASS
TMEM117	84216	broad.mit.edu	37	12	44770376	44770376	+	Splice_Site	SNP	A	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr12:44770376A>G	uc001rod.2	+	7	835	c.769_splice	c.e7-2	p.D257_splice	TMEM117_uc001roe.2_Splice_Site_p.D153_splice|TMEM117_uc009zkc.2_Intron	NM_032256	NP_115632	Q9H0C3	TM117_HUMAN	transmembrane protein 117							endoplasmic reticulum|integral to membrane					0	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		TTTCTCTGACAGGACTGGGAA	0.353													20	100	---	---	---	---	PASS
TMEM117	84216	broad.mit.edu	37	12	44770378	44770378	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr12:44770378G>T	uc001rod.2	+	7	835	c.769G>T	c.(769-771)GAC>TAC	p.D257Y	TMEM117_uc001roe.2_Missense_Mutation_p.D153Y|TMEM117_uc009zkc.2_Intron	NM_032256	NP_115632	Q9H0C3	TM117_HUMAN	transmembrane protein 117	257	Helical; (Potential).					endoplasmic reticulum|integral to membrane					0	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		TCTCTGACAGGACTGGGAATT	0.353													21	100	---	---	---	---	PASS
ARID2	196528	broad.mit.edu	37	12	46243515	46243515	+	Missense_Mutation	SNP	G	T	T	rs150280339		TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr12:46243515G>T	uc001ros.1	+	14	1868	c.1868G>T	c.(1867-1869)CGT>CTT	p.R623L	ARID2_uc001ror.2_Missense_Mutation_p.R623L|ARID2_uc009zkg.1_Missense_Mutation_p.R79L|ARID2_uc009zkh.1_Missense_Mutation_p.R250L|ARID2_uc001rou.1_5'Flank	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	623					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TCTGTTGTTCGTGTTGATTCT	0.383													43	134	---	---	---	---	PASS
MLL2	8085	broad.mit.edu	37	12	49441822	49441822	+	Missense_Mutation	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr12:49441822G>A	uc001rta.3	-	14	4162	c.4162C>T	c.(4162-4164)CGG>TGG	p.R1388W		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1388	PHD-type 3.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TCTGCCCCCCGGCCAAAGCTG	0.547			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			14	81	---	---	---	---	PASS
TIMELESS	8914	broad.mit.edu	37	12	56815268	56815268	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr12:56815268C>A	uc001slf.2	-	23	2903	c.2735G>T	c.(2734-2736)GGT>GTT	p.G912V		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	912					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						CATGATATGACCCAGGACATC	0.478													14	128	---	---	---	---	PASS
KIF5A	3798	broad.mit.edu	37	12	57969023	57969023	+	Nonsense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr12:57969023G>T	uc001sor.1	+	16	2081	c.1873G>T	c.(1873-1875)GAG>TAG	p.E625*	KIF5A_uc010srr.1_Nonsense_Mutation_p.E536*	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	625					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3						GACCGGGCGGGAGCTCTCATC	0.542													10	25	---	---	---	---	PASS
KCNC2	3747	broad.mit.edu	37	12	75444822	75444822	+	Silent	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr12:75444822C>A	uc001sxg.1	-	3	1507	c.963G>T	c.(961-963)GTG>GTT	p.V321V	KCNC2_uc009zry.2_Silent_p.V321V|KCNC2_uc001sxe.2_Silent_p.V321V|KCNC2_uc001sxf.2_Silent_p.V321V|KCNC2_uc010stw.1_Silent_p.V321V	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	321	Helical; Name=Segment S3; (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						GTAGGATGGCCACAAAGTCAA	0.408													15	60	---	---	---	---	PASS
NAV3	89795	broad.mit.edu	37	12	78511901	78511901	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr12:78511901G>T	uc001syp.2	+	14	3037	c.2864G>T	c.(2863-2865)GGG>GTG	p.G955V	NAV3_uc001syo.2_Missense_Mutation_p.G955V|NAV3_uc010sub.1_Missense_Mutation_p.G455V|NAV3_uc009zsf.2_5'UTR	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	955						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GACAGCCATGGGGATGCTGGT	0.512										HNSCC(70;0.22)			44	118	---	---	---	---	PASS
FGD6	55785	broad.mit.edu	37	12	95535176	95535176	+	Missense_Mutation	SNP	C	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr12:95535176C>G	uc001tdp.3	-	6	3049	c.2825G>C	c.(2824-2826)AGA>ACA	p.R942T	FGD6_uc009zsx.2_Missense_Mutation_p.R75T	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	942	DH.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3						GTGCAACATTCTTTCCTCCAG	0.428													5	57	---	---	---	---	PASS
TAOK3	51347	broad.mit.edu	37	12	118599636	118599636	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr12:118599636C>T	uc001twx.2	-	18	2391	c.2096G>A	c.(2095-2097)AGA>AAA	p.R699K	TAOK3_uc001twv.2_Missense_Mutation_p.R239K|TAOK3_uc001tww.2_Missense_Mutation_p.R529K|TAOK3_uc001twy.3_Missense_Mutation_p.R699K	NM_016281	NP_057365	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	699					MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GACATGCTTTCTGTGCAGTTC	0.418													42	206	---	---	---	---	PASS
CCDC60	160777	broad.mit.edu	37	12	119978478	119978478	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr12:119978478C>A	uc001txe.2	+	14	2076	c.1611C>A	c.(1609-1611)AGC>AGA	p.S537R	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	537										ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		GGCTGCAGAGCCGGATCAACA	0.522													30	91	---	---	---	---	PASS
TMEM132B	114795	broad.mit.edu	37	12	126068503	126068503	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr12:126068503C>A	uc001uhe.1	+	5	1393	c.1385C>A	c.(1384-1386)TCT>TAT	p.S462Y		NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	462	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GTGTCTGAGTCTGTGGAATGC	0.478													81	212	---	---	---	---	PASS
ZMYM5	9205	broad.mit.edu	37	13	20413041	20413041	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr13:20413041C>T	uc010tcn.1	-	5	936	c.671G>A	c.(670-672)CGT>CAT	p.R224H	ZMYM5_uc001umm.1_Missense_Mutation_p.R48H|ZMYM5_uc001umn.2_Missense_Mutation_p.R224H|ZMYM5_uc001umo.2_Intron	NM_001142684	NP_001136156	Q9UJ78	ZMYM5_HUMAN	zinc finger protein 237 isoform 3	224						nucleus	zinc ion binding				0		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)		ATTCTGCTTACGAAGTAAGGC	0.418													6	215	---	---	---	---	PASS
BRCA2	675	broad.mit.edu	37	13	32915254	32915254	+	Silent	SNP	T	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr13:32915254T>C	uc001uub.1	+	11	6989	c.6762T>C	c.(6760-6762)TTT>TTC	p.F2254F		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2254					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		ATTCTCTTTTTACATGTCCCG	0.363			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			49	120	---	---	---	---	PASS
OR4N5	390437	broad.mit.edu	37	14	20612691	20612691	+	Missense_Mutation	SNP	C	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr14:20612691C>G	uc010tla.1	+	1	797	c.797C>G	c.(796-798)CCA>CGA	p.P266R		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	266	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		CAGGCTTTCCCAGCTGACAAG	0.428													51	179	---	---	---	---	PASS
CHD8	57680	broad.mit.edu	37	14	21894357	21894357	+	Missense_Mutation	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr14:21894357G>A	uc001was.1	-	5	903	c.809C>T	c.(808-810)TCA>TTA	p.S270L	CHD8_uc001war.1_Missense_Mutation_p.S166L	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	549					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		ATTATCAGATGAGGTATTACG	0.373													8	23	---	---	---	---	PASS
KHNYN	23351	broad.mit.edu	37	14	24901069	24901069	+	Missense_Mutation	SNP	A	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr14:24901069A>C	uc001wph.3	+	3	804	c.602A>C	c.(601-603)CAG>CCG	p.Q201P	KHNYN_uc010tpc.1_Missense_Mutation_p.Q242P|KHNYN_uc010alw.2_Missense_Mutation_p.Q201P|CBLN3_uc001wpg.3_5'Flank	NM_015299	NP_056114	O15037	KHNYN_HUMAN	hypothetical protein LOC23351	201										ovary(2)|liver(1)	3						TCTAGTGGGCAGGGGCCAGGA	0.657											OREG0022627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	86	---	---	---	---	PASS
C14orf101	54916	broad.mit.edu	37	14	57114058	57114058	+	Missense_Mutation	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr14:57114058G>A	uc001xcm.2	+	16	2089	c.1967G>A	c.(1966-1968)AGA>AAA	p.R656K	C14orf101_uc001xcj.2_RNA|C14orf101_uc001xcn.2_RNA|C14orf101_uc010trf.1_Missense_Mutation_p.R189K|C14orf101_uc001xco.2_Missense_Mutation_p.R189K	NM_017799	NP_060269	Q9NX78	CN101_HUMAN	hypothetical protein LOC54916	656						integral to membrane				breast(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(311;0.226)		CTTCAGGCAAGAGATGCAGAT	0.458													8	48	---	---	---	---	PASS
HIF1A	3091	broad.mit.edu	37	14	62187261	62187261	+	Missense_Mutation	SNP	A	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr14:62187261A>G	uc001xfq.2	+	2	601	c.197A>G	c.(196-198)TAT>TGT	p.Y66C	HIF1A_uc010tsc.1_Intron|HIF1A_uc001xfr.2_Missense_Mutation_p.Y66C|HIF1A_uc001xfs.2_Missense_Mutation_p.Y67C	NM_001530	NP_001521	Q16665	HIF1A_HUMAN	hypoxia-inducible factor 1, alpha subunit	66	Interaction with TSGA10 (By similarity).|Helix-loop-helix motif.				cellular response to hypoxia|collagen metabolic process|connective tissue replacement involved in inflammatory response wound healing|elastin metabolic process|epithelial to mesenchymal transition|oxygen homeostasis|positive regulation of chemokine production|positive regulation of epithelial cell migration|positive regulation of hormone biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of transforming growth factor-beta2 production	cytoplasm|nucleolus|transcription factor complex	histone acetyltransferase binding|Hsp90 protein binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			kidney(3)|lung(1)	4				OV - Ovarian serous cystadenocarcinoma(108;1.62e-09)|BRCA - Breast invasive adenocarcinoma(234;0.189)		ACCATCAGCTATTTGCGTGTG	0.373													18	70	---	---	---	---	PASS
TMEM229B	161145	broad.mit.edu	37	14	67940583	67940583	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr14:67940583C>T	uc001xjk.2	-	3	468	c.58G>A	c.(58-60)GGC>AGC	p.G20S	TMEM229B_uc001xjj.1_RNA	NM_182526	NP_872332	Q8NBD8	T229B_HUMAN	transmembrane protein 229B	20	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1						CAGAAGTAGCCGTGGATGGCA	0.642													14	25	---	---	---	---	PASS
FLRT2	23768	broad.mit.edu	37	14	86089392	86089392	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr14:86089392G>T	uc001xvr.2	+	2	2301	c.1534G>T	c.(1534-1536)GCC>TCC	p.A512S	FLRT2_uc010atd.2_Missense_Mutation_p.A512S	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	512	Extracellular (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TTGTTCAGAGGCCACCACCCA	0.562													41	100	---	---	---	---	PASS
TTC7B	145567	broad.mit.edu	37	14	91059951	91059951	+	Silent	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr14:91059951C>A	uc001xyp.2	-	18	2108	c.1986G>T	c.(1984-1986)TCG>TCT	p.S662S	TTC7B_uc001xyo.2_Silent_p.S106S|TTC7B_uc010ats.2_RNA	NM_001010854	NP_001010854	Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	662							binding			ovary(2)	2		Melanoma(154;0.222)				AGGCTGCTACCGATGTGGCAT	0.582													25	50	---	---	---	---	PASS
DYNC1H1	1778	broad.mit.edu	37	14	102471151	102471151	+	Nonsense_Mutation	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr14:102471151G>A	uc001yks.2	+	25	5266	c.5102G>A	c.(5101-5103)TGG>TAG	p.W1701*		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	1701	Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						ATCAATGAGTGGCTCACATTG	0.373													4	42	---	---	---	---	PASS
KIF26A	26153	broad.mit.edu	37	14	104638965	104638965	+	Silent	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr14:104638965G>T	uc001yos.3	+	7	1380	c.1380G>T	c.(1378-1380)GGG>GGT	p.G460G		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	460	Kinesin-motor.				blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		TGGTCAGTGGGGCTGATGGCT	0.632													8	29	---	---	---	---	PASS
GOLGA8E	390535	broad.mit.edu	37	15	23445400	23445400	+	Missense_Mutation	SNP	T	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr15:23445400T>A	uc001yvu.2	+	18	2220	c.1231T>A	c.(1231-1233)TTG>ATG	p.L411M	uc001yvx.2_5'Flank	NM_001012423	NP_001012423			golgi autoantigen, golgin subfamily a, 8E											skin(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;5.21e-07)|Epithelial(43;5.65e-06)|BRCA - Breast invasive adenocarcinoma(123;0.000614)		GCACCCAGGCTTGGGCAGCAA	0.552													23	111	---	---	---	---	PASS
STRC	161497	broad.mit.edu	37	15	43896213	43896213	+	Silent	SNP	T	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr15:43896213T>A	uc001zsf.2	-	22	4434	c.4356A>T	c.(4354-4356)CCA>CCT	p.P1452P	STRC_uc010bdl.2_Silent_p.P679P|STRC_uc001zse.2_5'UTR	NM_153700	NP_714544	Q7RTU9	STRC_HUMAN	stereocilin precursor	1452					sensory perception of sound	cell surface					0		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		CCTCAGCAGCTGGTCGCACCA	0.517													16	48	---	---	---	---	PASS
MAPK6	5597	broad.mit.edu	37	15	52353666	52353666	+	Nonsense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr15:52353666G>T	uc002abp.2	+	5	1830	c.1036G>T	c.(1036-1038)GAA>TAA	p.E346*		NM_002748	NP_002739	Q16659	MK06_HUMAN	mitogen-activated protein kinase 6	346					cell cycle		ATP binding|MAP kinase activity			lung(3)|ovary(1)	4				all cancers(107;0.0028)		GCTTATGGATGAAACTCACAG	0.318													16	27	---	---	---	---	PASS
PSTPIP1	9051	broad.mit.edu	37	15	77310525	77310525	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr15:77310525C>A	uc002bcf.2	+	2	523	c.73C>A	c.(73-75)CTG>ATG	p.L25M	PSTPIP1_uc010bkt.1_RNA|PSTPIP1_uc010umo.1_Translation_Start_Site|PSTPIP1_uc010bku.1_Missense_Mutation_p.L16M|PSTPIP1_uc002bcg.2_Missense_Mutation_p.L25M|PSTPIP1_uc010bkv.1_RNA|PSTPIP1_uc010bkw.1_Missense_Mutation_p.L25M	NM_003978	NP_003969	O43586	PPIP1_HUMAN	proline-serine-threonine phosphatase interacting	25	FCH.				cell adhesion|signal transduction	cleavage furrow|lamellipodium|perinuclear region of cytoplasm	catalytic activity			ovary(1)	1						CTACGAGGTGCTGCTGCAGCG	0.622													4	3	---	---	---	---	PASS
CACNA1H	8912	broad.mit.edu	37	16	1254227	1254227	+	Missense_Mutation	SNP	G	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr16:1254227G>C	uc002cks.2	+	10	2468	c.2220G>C	c.(2218-2220)TGG>TGC	p.W740C	CACNA1H_uc002ckt.2_Missense_Mutation_p.W740C	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	740	Cytoplasmic (Potential).				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GTGACCGCTGGGACCCCACGC	0.711													5	19	---	---	---	---	PASS
ABCA3	21	broad.mit.edu	37	16	2353971	2353971	+	Missense_Mutation	SNP	A	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr16:2353971A>G	uc002cpy.1	-	12	2178	c.1466T>C	c.(1465-1467)ATG>ACG	p.M489T	ABCA3_uc010bsk.1_Missense_Mutation_p.M431T|ABCA3_uc010bsl.1_Missense_Mutation_p.M489T	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	489					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				AGAACTCACCATGATGAAGAA	0.612													11	40	---	---	---	---	PASS
A2BP1	54715	broad.mit.edu	37	16	7568315	7568315	+	Missense_Mutation	SNP	T	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr16:7568315T>C	uc002cys.2	+	5	1182	c.194T>C	c.(193-195)CTG>CCG	p.L65P	A2BP1_uc010buf.1_Missense_Mutation_p.L65P|A2BP1_uc002cyr.1_Missense_Mutation_p.L65P|A2BP1_uc002cyt.2_Missense_Mutation_p.L65P|A2BP1_uc010uxz.1_Missense_Mutation_p.L108P|A2BP1_uc010uya.1_Missense_Mutation_p.L101P|A2BP1_uc002cyv.1_Missense_Mutation_p.L65P|A2BP1_uc010uyb.1_Missense_Mutation_p.L65P|A2BP1_uc002cyw.2_Missense_Mutation_p.L85P|A2BP1_uc002cyy.2_Missense_Mutation_p.L85P|A2BP1_uc002cyx.2_Missense_Mutation_p.L85P|A2BP1_uc010uyc.1_Missense_Mutation_p.L85P	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	65					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		ACATTAAACCTGTACCCTCCC	0.657													31	152	---	---	---	---	PASS
IQCK	124152	broad.mit.edu	37	16	19741816	19741816	+	Silent	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr16:19741816G>T	uc002dgr.2	+	3	945	c.246G>T	c.(244-246)ACG>ACT	p.T82T	IQCK_uc002dgs.2_RNA|IQCK_uc010vat.1_Silent_p.T82T|IQCK_uc010bwc.2_RNA|IQCK_uc010vau.1_Intron	NM_153208	NP_694940	Q8N0W5	IQCK_HUMAN	IQ motif containing K	82										skin(1)	1						CTGTGATTACGGTGAGTATTA	0.443													24	52	---	---	---	---	PASS
ACSM2A	123876	broad.mit.edu	37	16	20492174	20492174	+	Missense_Mutation	SNP	T	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr16:20492174T>G	uc010bwe.2	+	13	1679	c.1440T>G	c.(1438-1440)AAT>AAG	p.N480K	ACSM2A_uc010vax.1_Missense_Mutation_p.N401K|ACSM2A_uc002dhf.3_Missense_Mutation_p.N480K|ACSM2A_uc002dhg.3_Missense_Mutation_p.N480K|ACSM2A_uc010vay.1_Missense_Mutation_p.N401K|ACSM2A_uc002dhh.3_Missense_Mutation_p.N110K	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	480					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						AGGTAGAGAATGCACTGATGG	0.582													22	89	---	---	---	---	PASS
VWA3A	146177	broad.mit.edu	37	16	22134943	22134943	+	Missense_Mutation	SNP	A	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr16:22134943A>T	uc010vbq.1	+	16	1543	c.1447A>T	c.(1447-1449)AGC>TGC	p.S483C	VWA3A_uc010bxd.2_RNA|VWA3A_uc010bxc.2_Missense_Mutation_p.S491C	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	483						extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)		GCAACAGCTCAGCAGAGCTAT	0.562													27	118	---	---	---	---	PASS
ERN2	10595	broad.mit.edu	37	16	23703384	23703384	+	Missense_Mutation	SNP	C	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr16:23703384C>G	uc002dma.3	-	19	2589	c.2420G>C	c.(2419-2421)GGA>GCA	p.G807A	ERN2_uc010bxp.2_Missense_Mutation_p.G755A	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	759	Protein kinase.|Cytoplasmic (Potential).			G -> A (in Ref. 1; BAB21297).	apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		CAACATGGCTCCAACCAGGTC	0.632													73	186	---	---	---	---	PASS
ABCC11	85320	broad.mit.edu	37	16	48249217	48249217	+	Silent	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr16:48249217G>A	uc002eff.1	-	7	1340	c.990C>T	c.(988-990)CAC>CAT	p.H330H	ABCC11_uc002efg.1_Silent_p.H330H|ABCC11_uc002efh.1_Silent_p.H330H|ABCC11_uc010vgk.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	330	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				CCTCAGATGTGTGATGCTGAG	0.468									Cerumen_Type				21	58	---	---	---	---	PASS
LONP2	83752	broad.mit.edu	37	16	48304001	48304001	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr16:48304001G>T	uc002efi.1	+	7	1146	c.1057G>T	c.(1057-1059)GTA>TTA	p.V353L	LONP2_uc010vgm.1_RNA|LONP2_uc002efj.1_Missense_Mutation_p.V309L	NM_031490	NP_113678	Q86WA8	LONP2_HUMAN	peroxisomal LON protease-like	353					misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0						GAAGAAAAGAGTACTGGAATA	0.448													22	63	---	---	---	---	PASS
ZNF423	23090	broad.mit.edu	37	16	49764751	49764751	+	Missense_Mutation	SNP	C	A	A	rs149531360		TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr16:49764751C>A	uc002efs.2	-	4	506	c.208G>T	c.(208-210)GAT>TAT	p.D70Y		NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	70	C2H2-type 1; degenerate.				cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				TGACAGTGATCGCAGGTGTAA	0.542													61	168	---	---	---	---	PASS
NOD2	64127	broad.mit.edu	37	16	50745745	50745745	+	Silent	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr16:50745745C>A	uc002egm.1	+	4	2028	c.1923C>A	c.(1921-1923)GCC>GCA	p.A641A	NOD2_uc010cbk.1_Silent_p.A614A|NOD2_uc002egl.1_Silent_p.A419A|NOD2_uc010cbl.1_Silent_p.A419A|NOD2_uc010cbm.1_Silent_p.A419A|NOD2_uc010cbn.1_RNA|NOD2_uc010cbo.1_RNA|NOD2_uc010cbp.1_5'Flank|NOD2_uc010cbq.1_5'Flank|NOD2_uc010cbr.1_5'Flank	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	641					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				CACCAATGGCCAGGCTCCTGC	0.592													19	57	---	---	---	---	PASS
LPCAT2	54947	broad.mit.edu	37	16	55579725	55579725	+	Missense_Mutation	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr16:55579725G>A	uc002eie.3	+	9	1112	c.931G>A	c.(931-933)GCA>ACA	p.A311T	LPCAT2_uc002eic.2_Missense_Mutation_p.A41T	NM_017839	NP_060309	Q7L5N7	PCAT2_HUMAN	lysophosphatidylcholine acyltransferase 2	311	Lumenal (Potential).				cellular membrane organization|platelet activating factor biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|Golgi stack|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding				0						GAATTTAATGGCAGAGTAAGT	0.299													23	73	---	---	---	---	PASS
SLC9A5	6553	broad.mit.edu	37	16	67289690	67289690	+	Silent	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr16:67289690C>T	uc002esm.2	+	5	831	c.768C>T	c.(766-768)GCC>GCT	p.A256A	SLC9A5_uc010cee.2_5'UTR|SLC9A5_uc010vji.1_Intron	NM_004594	NP_004585	Q14940	SL9A5_HUMAN	solute carrier family 9 (sodium/hydrogen	256	Helical; (Potential).				regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			ovary(1)|pancreas(1)	2		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		GCGGGGCAGCCGTGGGCTTAG	0.652													6	12	---	---	---	---	PASS
ZFP90	146198	broad.mit.edu	37	16	68597569	68597569	+	Silent	SNP	T	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr16:68597569T>C	uc010cff.2	+	5	1171	c.879T>C	c.(877-879)CAT>CAC	p.H293H	ZFP90_uc002ewb.2_Missense_Mutation_p.I99T|ZFP90_uc002ewc.2_Missense_Mutation_p.I99T|ZFP90_uc002ewd.2_Silent_p.H293H|ZFP90_uc002ewe.2_Silent_p.H293H	NM_133458	NP_597715	Q8TF47	ZFP90_HUMAN	zinc finger protein 90	293	C2H2-type 3.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		CCTTCAGGCATAGCTCATCTC	0.488													16	93	---	---	---	---	PASS
ZFP90	146198	broad.mit.edu	37	16	68598059	68598059	+	Nonsense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr16:68598059G>T	uc010cff.2	+	5	1661	c.1369G>T	c.(1369-1371)GAA>TAA	p.E457*	ZFP90_uc002ewb.2_3'UTR|ZFP90_uc002ewc.2_3'UTR|ZFP90_uc002ewd.2_Nonsense_Mutation_p.E457*|ZFP90_uc002ewe.2_Nonsense_Mutation_p.E457*	NM_133458	NP_597715	Q8TF47	ZFP90_HUMAN	zinc finger protein 90	457	C2H2-type 8.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		TGACTGTGGGGAAGACTTTAG	0.423													31	100	---	---	---	---	PASS
CNTNAP4	85445	broad.mit.edu	37	16	76501369	76501369	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr16:76501369C>A	uc002feu.1	+	12	1989	c.1604C>A	c.(1603-1605)TCC>TAC	p.S535Y	CNTNAP4_uc002fev.1_Missense_Mutation_p.S399Y|CNTNAP4_uc010chb.1_Missense_Mutation_p.S462Y|CNTNAP4_uc002fex.1_Missense_Mutation_p.S538Y|CNTNAP4_uc002few.2_Missense_Mutation_p.S510Y	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	535	Extracellular (Potential).|Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						CAGCAGGGGTCCCTTGGGAAC	0.453													11	50	---	---	---	---	PASS
ENO3	2027	broad.mit.edu	37	17	4860153	4860153	+	Missense_Mutation	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr17:4860153G>A	uc002gab.3	+	11	1298	c.1204G>A	c.(1204-1206)GAG>AAG	p.E402K	ENO3_uc002gac.3_Missense_Mutation_p.E402K|ENO3_uc010vss.1_Missense_Mutation_p.E359K|ENO3_uc010vst.1_Missense_Mutation_p.E229K	NM_053013	NP_443739	P13929	ENOB_HUMAN	enolase 3	402					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex	magnesium ion binding|phosphopyruvate hydratase activity			ovary(1)	1						CTGCCGCTCGGAGCGTCTGGC	0.592											OREG0024110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	48	134	---	---	---	---	PASS
ALOXE3	59344	broad.mit.edu	37	17	8018962	8018962	+	Missense_Mutation	SNP	T	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr17:8018962T>C	uc010cnr.2	-	4	767	c.397A>G	c.(397-399)AGG>GGG	p.R133G	ALOXE3_uc002gka.2_Missense_Mutation_p.R289G|ALOXE3_uc010vuo.1_Missense_Mutation_p.R265G|ALOXE3_uc010vup.1_RNA	NM_021628	NP_067641	Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3 isoform 2	133	Lipoxygenase.				leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			skin(3)|lung(1)|central_nervous_system(1)	5						TCCCGTGTCCTGTGATCCAGG	0.473													3	84	---	---	---	---	PASS
MYH8	4626	broad.mit.edu	37	17	10297598	10297598	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr17:10297598C>A	uc002gmm.2	-	35	5229	c.5134G>T	c.(5134-5136)GCC>TCC	p.A1712S	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1712	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						CGCTCACTGGCATCCAGGAGC	0.542									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				29	61	---	---	---	---	PASS
MYH2	4620	broad.mit.edu	37	17	10443973	10443973	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr17:10443973C>A	uc010coi.2	-	11	1074	c.946G>T	c.(946-948)GTC>TTC	p.V316F	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.V316F|MYH2_uc010coj.2_Missense_Mutation_p.V316F	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	316	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CCTTGACTGACAAATGGGTAA	0.378													23	55	---	---	---	---	PASS
DNAH9	1770	broad.mit.edu	37	17	11837356	11837356	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr17:11837356C>A	uc002gne.2	+	65	12525	c.12457C>A	c.(12457-12459)CCA>ACA	p.P4153T	DNAH9_uc010coo.2_Missense_Mutation_p.P3371T|DNAH9_uc002gnf.2_Missense_Mutation_p.P465T	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	4153					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GTTCCCACTCCCAGGCAACAT	0.532													40	99	---	---	---	---	PASS
SARM1	23098	broad.mit.edu	37	17	26708234	26708234	+	Silent	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr17:26708234G>T	uc010crl.1	+	5	550	c.483G>T	c.(481-483)GCG>GCT	p.A161A	SARM1_uc010wah.1_Missense_Mutation_p.A182S|SARM1_uc010waj.1_RNA	NM_015077	NP_055892	Q6SZW1	SARM1_HUMAN	sterile alpha and TIR motif containing 1	161					innate immune response	cytoplasm|intrinsic to membrane	binding|transmembrane receptor activity				0	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		ACCGCGTGGCGCGCATTGGGC	0.612													3	15	---	---	---	---	PASS
PNMT	5409	broad.mit.edu	37	17	37825907	37825907	+	Silent	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr17:37825907C>T	uc002hsi.1	+	2	450	c.228C>T	c.(226-228)ATC>ATT	p.I76I		NM_002686	NP_002677	P11086	PNMT_HUMAN	phenylethanolamine N-methyltransferase	76					catecholamine biosynthetic process|hormone biosynthetic process	cytosol	phenylethanolamine N-methyltransferase activity			ovary(1)	1	all_cancers(6;6.59e-85)|all_epithelial(6;2.89e-103)|Breast(7;1.05e-86)|Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;3.87e-45)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GCACCCTCATCGACATTGGTT	0.632													7	52	---	---	---	---	PASS
GPATCH8	23131	broad.mit.edu	37	17	42476454	42476454	+	Missense_Mutation	SNP	C	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr17:42476454C>G	uc002igw.1	-	8	3055	c.2991G>C	c.(2989-2991)AGG>AGC	p.R997S	GPATCH8_uc002igv.1_Missense_Mutation_p.R919S|GPATCH8_uc010wiz.1_Missense_Mutation_p.R919S	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	997	Ser-rich.					intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		GGGAAGGGCTCCTGGTGCTGC	0.602													3	36	---	---	---	---	PASS
ADAM11	4185	broad.mit.edu	37	17	42849019	42849019	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr17:42849019C>T	uc002ihh.2	+	5	449	c.449C>T	c.(448-450)TCC>TTC	p.S150F	ADAM11_uc010wjd.1_5'UTR	NM_002390	NP_002381	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11 preproprotein	150					integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			pancreas(1)	1		Prostate(33;0.0959)				GCCGCCCTCTCCACCTGCCAG	0.687													9	81	---	---	---	---	PASS
FAM117A	81558	broad.mit.edu	37	17	47794918	47794918	+	Silent	SNP	A	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr17:47794918A>G	uc002ipk.2	-	6	936	c.867T>C	c.(865-867)CAT>CAC	p.H289H	FAM117A_uc010wlz.1_Silent_p.H17H	NM_030802	NP_110429	Q9C073	F117A_HUMAN	family with sequence similarity 117, member A	289										ovary(1)	1						CGGCACCCCGATGTTCCTCAT	0.632													4	62	---	---	---	---	PASS
TRIM25	7706	broad.mit.edu	37	17	54969297	54969297	+	Missense_Mutation	SNP	A	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr17:54969297A>T	uc002iut.2	-	9	1717	c.1657T>A	c.(1657-1659)TGG>AGG	p.W553R	TRIM25_uc010dcj.2_Missense_Mutation_p.W345R	NM_005082	NP_005073	Q14258	TRI25_HUMAN	tripartite motif-containing 25	553	B30.2/SPRY.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|response to virus	cell junction|cytosol|nucleus	sequence-specific DNA binding transcription factor activity|ubiquitin-protein ligase activity|zinc ion binding			lung(1)|breast(1)|skin(1)	3	Breast(9;6.15e-08)					GTGTTGAACCACTCCACGCAC	0.602													15	63	---	---	---	---	PASS
RGS9	8787	broad.mit.edu	37	17	63198196	63198196	+	Nonsense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr17:63198196C>A	uc002jfe.2	+	14	1172	c.1062C>A	c.(1060-1062)TAC>TAA	p.Y354*	RGS9_uc010dem.2_Nonsense_Mutation_p.Y351*|RGS9_uc002jfd.2_Nonsense_Mutation_p.Y351*|RGS9_uc002jff.2_RNA|RGS9_uc002jfg.2_Nonsense_Mutation_p.Y125*	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	354	RGS.				intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						AGGAGATTTACAAGTGAGCAT	0.522													11	62	---	---	---	---	PASS
DNAI2	64446	broad.mit.edu	37	17	72285877	72285877	+	Splice_Site	SNP	T	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr17:72285877T>A	uc002jkf.2	+	5	709	c.610_splice	c.e5+2	p.E204_splice	DNAI2_uc002jkg.2_Splice_Site|DNAI2_uc010dfp.2_Splice_Site	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2						cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						GGGACCTGGGTGAGAAGCAGC	0.627									Kartagener_syndrome				14	50	---	---	---	---	PASS
TBC1D16	125058	broad.mit.edu	37	17	77923628	77923628	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr17:77923628C>T	uc002jxj.2	-	7	1410	c.1294G>A	c.(1294-1296)GGG>AGG	p.G432R	TBC1D16_uc002jxh.2_Missense_Mutation_p.G70R|TBC1D16_uc002jxi.2_Intron|TBC1D16_uc002jxk.1_Missense_Mutation_p.G70R	NM_019020	NP_061893	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	432	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)			CAGACCTCCCCGCGGATTGAC	0.577													7	69	---	---	---	---	PASS
FAM38B	63895	broad.mit.edu	37	18	10696398	10696398	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr18:10696398C>A	uc002kor.3	-	4	639	c.499G>T	c.(499-501)GCC>TCC	p.A167S	FAM38B_uc002koq.2_Missense_Mutation_p.A65S	NM_022068	NP_071351	Q9H5I5	PIEZ2_HUMAN	family with sequence similarity 38, member B	2210	Helical; (Potential).					integral to membrane	ion channel activity			ovary(1)	1						ACCCCAAAGGCCCAAAAGCCG	0.547													19	66	---	---	---	---	PASS
FAM38B	63895	broad.mit.edu	37	18	10696517	10696517	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr18:10696517G>T	uc002kor.3	-	4	520	c.380C>A	c.(379-381)CCC>CAC	p.P127H	FAM38B_uc002koq.2_Missense_Mutation_p.P25H	NM_022068	NP_071351	Q9H5I5	PIEZ2_HUMAN	family with sequence similarity 38, member B	2170						integral to membrane	ion channel activity			ovary(1)	1						CTGTTTGATGGGCACATAGAT	0.517													18	89	---	---	---	---	PASS
DSC3	1825	broad.mit.edu	37	18	28598197	28598197	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr18:28598197G>T	uc002kwj.3	-	9	1258	c.1103C>A	c.(1102-1104)GCA>GAA	p.A368E	DSC3_uc002kwi.3_Missense_Mutation_p.A368E	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	368	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			CACATTGAATGCATTTTCCTC	0.279													16	32	---	---	---	---	PASS
ASXL3	80816	broad.mit.edu	37	18	31325404	31325404	+	Silent	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr18:31325404C>A	uc010dmg.1	+	12	5647	c.5592C>A	c.(5590-5592)GGC>GGA	p.G1864G	ASXL3_uc002kxq.2_Silent_p.G1571G	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1864					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						TCAGTTCCGGCATCAGTCAGC	0.463													78	222	---	---	---	---	PASS
ZNF271	10778	broad.mit.edu	37	18	32887790	32887790	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr18:32887790G>T	uc002kyq.3	+	3	2194	c.1202G>T	c.(1201-1203)TGT>TTT	p.C401F	ZNF271_uc002kyp.3_Missense_Mutation_p.C401F|ZNF271_uc002kyr.3_Missense_Mutation_p.C401F	NR_024565				SubName: Full=cDNA FLJ13394 fis, clone PLACE1001304, highly similar to Homo sapiens zinc finger protein 271 (ZNF271), mRNA;												0						CCTTTAGTGTGTACACCAACT	0.363													14	45	---	---	---	---	PASS
RIT2	6014	broad.mit.edu	37	18	40695401	40695401	+	Silent	SNP	T	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr18:40695401T>C	uc002lav.2	-	1	257	c.84A>G	c.(82-84)GCA>GCG	p.A28A	RIT2_uc010dnf.2_Silent_p.A28A	NM_002930	NP_002921	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	28	GTP (By similarity).				nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			ovary(1)	1						CAACTCCCCCTGCTCCCAGCA	0.517													44	110	---	---	---	---	PASS
FGF22	27006	broad.mit.edu	37	19	643539	643539	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:643539C>T	uc010xfq.1	+	3	448	c.448C>T	c.(448-450)CGG>TGG	p.R150W	FGF22_uc010xfr.1_Missense_Mutation_p.P142L	NM_020637	NP_065688	Q9HCT0	FGF22_HUMAN	fibroblast growth factor 22 precursor	150					cell differentiation|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	extracellular space	growth factor activity				0		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		gggggggccccggccaggcgg	0.572													4	16	---	---	---	---	PASS
C19orf21	126353	broad.mit.edu	37	19	758684	758684	+	Nonsense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:758684G>T	uc002lpo.2	+	2	1821	c.1738G>T	c.(1738-1740)GAG>TAG	p.E580*		NM_173481	NP_775752	Q8IVT2	CS021_HUMAN	hypothetical protein LOC126353	580										upper_aerodigestive_tract(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000145)|all_lung(49;0.000236)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AACGCCAGATGAGAACTCTGA	0.617													11	59	---	---	---	---	PASS
C19orf26	255057	broad.mit.edu	37	19	1233530	1233530	+	Missense_Mutation	SNP	T	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:1233530T>G	uc002lrm.2	-	8	1131	c.856A>C	c.(856-858)ACC>CCC	p.T286P		NM_152769	NP_689982	Q8N350	DOS_HUMAN	downstream of Stk11	312						integral to membrane					0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCAGGCGGGTGAGGAACTGC	0.697										HNSCC(14;0.022)			4	12	---	---	---	---	PASS
EEF2	1938	broad.mit.edu	37	19	3977846	3977846	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:3977846C>A	uc002lze.2	-	12	2121	c.2038G>T	c.(2038-2040)GTG>TTG	p.V680L		NM_001961	NP_001952	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2	680						cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGCCGGCCACCACACTGTCC	0.622													26	95	---	---	---	---	PASS
SH2D3A	10045	broad.mit.edu	37	19	6763757	6763757	+	Missense_Mutation	SNP	C	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:6763757C>G	uc002mft.2	-	2	197	c.3G>C	c.(1-3)ATG>ATC	p.M1I	SH2D3A_uc010xjg.1_5'UTR	NM_005490	NP_005481	Q9BRG2	SH23A_HUMAN	SH2 domain containing 3A	1					JNK cascade|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(2)	2						GTGGCACCTGCATGGAGCTCT	0.473													6	69	---	---	---	---	PASS
CLEC4G	339390	broad.mit.edu	37	19	7795279	7795279	+	Missense_Mutation	SNP	T	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:7795279T>C	uc002mhp.3	-	6	505	c.436A>G	c.(436-438)ACT>GCT	p.T146A		NM_198492	NP_940894	Q6UXB4	CLC4G_HUMAN	C-type lectin domain family 4, member G	146	Extracellular (Potential).					integral to membrane	protein binding|sugar binding				0						AACAGCTCAGTGCGGACGTCC	0.701													6	60	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9008248	9008248	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:9008248G>T	uc002mkp.2	-	41	39508	c.39304C>A	c.(39304-39306)CAG>AAG	p.Q13102K	MUC16_uc010dwi.2_5'Flank|MUC16_uc010dwj.2_5'Flank|MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGCTCAGCTGCCAGTACAGC	0.577													40	175	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9075049	9075049	+	Missense_Mutation	SNP	C	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:9075049C>G	uc002mkp.2	-	3	12601	c.12397G>C	c.(12397-12399)GAG>CAG	p.E4133Q		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4135	Thr-rich.|Extracellular (Potential).|Ser-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGGTCTTCTCTGAGTATGTA	0.512													21	88	---	---	---	---	PASS
ZNF560	147741	broad.mit.edu	37	19	9577701	9577701	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:9577701G>T	uc002mlp.1	-	10	2132	c.1922C>A	c.(1921-1923)TCC>TAC	p.S641Y	ZNF560_uc010dwr.1_Missense_Mutation_p.S535Y	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	641	C2H2-type 11; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						AACTAGACTGGAGGAGACAAC	0.393													26	100	---	---	---	---	PASS
S1PR5	53637	broad.mit.edu	37	19	10625146	10625146	+	Missense_Mutation	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:10625146G>A	uc002mot.1	-	2	599	c.542C>T	c.(541-543)GCT>GTT	p.A181V	S1PR5_uc002mou.1_Missense_Mutation_p.A181V	NM_030760	NP_110387	Q9H228	S1PR5_HUMAN	endothelial differentiation, sphingolipid	181	Extracellular (By similarity).					integral to membrane|plasma membrane	lysosphingolipid and lysophosphatidic acid receptor activity			central_nervous_system(1)|pancreas(1)	2						AGTGGAGCAAGCGTCCAGGCG	0.697													3	19	---	---	---	---	PASS
RASAL3	64926	broad.mit.edu	37	19	15567015	15567015	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:15567015C>A	uc002nbe.2	-	11	1707	c.1621G>T	c.(1621-1623)GTG>TTG	p.V541L	RASAL3_uc002nbd.2_5'Flank|RASAL3_uc010eaa.1_Missense_Mutation_p.V29L	NM_022904	NP_075055	Q86YV0	RASL3_HUMAN	RAS protein activator like 3	541	Ras-GAP.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity				0						CTGGGGTCCACTTCACAGTCC	0.587													9	49	---	---	---	---	PASS
CYP4F3	4051	broad.mit.edu	37	19	15760759	15760759	+	Silent	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:15760759C>A	uc002nbj.2	+	7	734	c.684C>A	c.(682-684)CTC>CTA	p.L228L	CYP4F3_uc010xok.1_Silent_p.L228L|CYP4F3_uc010xol.1_Silent_p.L228L|CYP4F3_uc010xom.1_Silent_p.L79L|CYP4F3_uc002nbk.2_Silent_p.L228L|CYP4F3_uc010xon.1_5'Flank	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	228					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						TCTTGGAGCTCAGTGCCCTTG	0.532													29	252	---	---	---	---	PASS
NWD1	284434	broad.mit.edu	37	19	16884028	16884028	+	Silent	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:16884028C>A	uc002neu.3	+	11	2924	c.2502C>A	c.(2500-2502)GCC>GCA	p.A834A	NWD1_uc002net.3_Silent_p.A699A|NWD1_uc002nev.3_Silent_p.A628A			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	834							ATP binding			skin(3)|ovary(2)|pancreas(2)	7						GCCAACAGGCCCAGAGCTGGT	0.622													10	70	---	---	---	---	PASS
UNC13A	23025	broad.mit.edu	37	19	17738671	17738671	+	Splice_Site	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:17738671C>A	uc002nhd.2	-	32	4095	c.4095_splice	c.e32+1	p.E1365_splice		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A						exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						CCCTGCCTCACCTCCTTTCCT	0.597													111	770	---	---	---	---	PASS
FCHO1	23149	broad.mit.edu	37	19	17881694	17881694	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:17881694G>T	uc010ebb.2	+	8	772	c.583G>T	c.(583-585)GAC>TAC	p.D195Y	FCHO1_uc002nhg.3_Missense_Mutation_p.D195Y|FCHO1_uc002nhh.2_Missense_Mutation_p.D195Y|FCHO1_uc010xpw.1_Missense_Mutation_p.D145Y|FCHO1_uc010ebc.1_Missense_Mutation_p.D202Y	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	195	Potential.									breast(1)	1						GAAGATGCTGGACTCAGCCCT	0.488													11	45	---	---	---	---	PASS
PDE4C	5143	broad.mit.edu	37	19	18322679	18322679	+	Missense_Mutation	SNP	T	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:18322679T>A	uc010xqc.1	-	14	2161	c.1681A>T	c.(1681-1683)ACG>TCG	p.T561S	PDE4C_uc002nik.3_Missense_Mutation_p.T561S|PDE4C_uc002nil.3_Missense_Mutation_p.T561S|PDE4C_uc002nif.3_Missense_Mutation_p.T330S|PDE4C_uc002nig.3_Missense_Mutation_p.T276S|PDE4C_uc002nih.3_Missense_Mutation_p.T331S|PDE4C_uc010ebk.2_Missense_Mutation_p.T455S|PDE4C_uc002nii.3_Missense_Mutation_p.T529S|PDE4C_uc010ebl.2_Missense_Mutation_p.T275S	NM_001098819	NP_001092289	Q08493	PDE4C_HUMAN	phosphodiesterase 4C isoform PDE4C-2	561					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|skin(2)|central_nervous_system(1)	5					Dyphylline(DB00651)	ATGCGGTCCGTCCACTGGCGG	0.617													11	71	---	---	---	---	PASS
NCAN	1463	broad.mit.edu	37	19	19338799	19338799	+	Silent	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:19338799G>A	uc002nlz.2	+	8	2469	c.2370G>A	c.(2368-2370)CTG>CTA	p.L790L	NCAN_uc010ecc.1_Silent_p.L354L	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	790					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			GCAAAGGGCTGGATGCAAGTT	0.577													10	76	---	---	---	---	PASS
ZNF253	56242	broad.mit.edu	37	19	20002979	20002979	+	Missense_Mutation	SNP	G	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:20002979G>C	uc002noj.2	+	4	1015	c.923G>C	c.(922-924)AGA>ACA	p.R308T	ZNF253_uc002nok.2_Missense_Mutation_p.R232T|ZNF253_uc002nol.2_RNA	NM_021047	NP_066385	O75346	ZN253_HUMAN	zinc finger protein 253	308				Missing (in Ref. 1; AAC26844).|Missing (in Ref. 2; BAC11185).	negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATTCATACTAGAGGGAAACCC	0.393													5	29	---	---	---	---	PASS
ZNF708	7562	broad.mit.edu	37	19	21476251	21476251	+	Missense_Mutation	SNP	C	A	A	rs149714173		TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:21476251C>A	uc002npq.1	-	4	1715	c.1517G>T	c.(1516-1518)TGT>TTT	p.C506F	ZNF708_uc002npr.1_Missense_Mutation_p.C442F|ZNF708_uc010ecs.1_Missense_Mutation_p.C442F	NM_021269	NP_067092	P17019	ZN708_HUMAN	zinc finger protein 708	506	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(4)|skin(2)	6						ACATTCTTTACATTTGTAGGG	0.363													10	56	---	---	---	---	PASS
PSENEN	55851	broad.mit.edu	37	19	36237348	36237348	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:36237348G>T	uc002obi.1	+	3	294	c.90G>T	c.(88-90)TGG>TGT	p.W30C	TMEM149_uc010eej.2_5'Flank|U2AF1L4_uc002obh.1_5'Flank|U2AF1L4_uc002obe.2_5'Flank|U2AF1L4_uc002obf.2_5'Flank|U2AF1L4_uc002obg.2_5'Flank|PSENEN_uc002obj.1_Missense_Mutation_p.W30C|PSENEN_uc002obk.1_RNA|LIN37_uc002obm.2_5'Flank	NM_172341	NP_758844	Q9NZ42	PEN2_HUMAN	presenilin enhancer 2	30	Helical; (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to plasma membrane	aspartic-type endopeptidase activity|protein binding			ovary(2)	2	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTTTTCTCTGGTTGGTCAACA	0.483													37	110	---	---	---	---	PASS
NOVA2	4858	broad.mit.edu	37	19	46476593	46476593	+	Missense_Mutation	SNP	G	C	C			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:46476593G>C	uc002pdv.2	-	1	65	c.17C>G	c.(16-18)CCG>CGG	p.P6R		NM_002516	NP_002507	Q9UNW9	NOVA2_HUMAN	neuro-oncological ventral antigen 2	6						nucleus	RNA binding				0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00245)|GBM - Glioblastoma multiforme(486;0.0782)|Epithelial(262;0.179)		GCGGGAATCCGGGGCCTCGGG	0.473													6	8	---	---	---	---	PASS
NOVA2	4858	broad.mit.edu	37	19	46476594	46476594	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:46476594G>T	uc002pdv.2	-	1	64	c.16C>A	c.(16-18)CCG>ACG	p.P6T		NM_002516	NP_002507	Q9UNW9	NOVA2_HUMAN	neuro-oncological ventral antigen 2	6						nucleus	RNA binding				0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00245)|GBM - Glioblastoma multiforme(486;0.0782)|Epithelial(262;0.179)		CGGGAATCCGGGGCCTCGGGC	0.468													5	8	---	---	---	---	PASS
C5AR1	728	broad.mit.edu	37	19	47823172	47823172	+	Silent	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:47823172C>T	uc002pgj.1	+	2	187	c.138C>T	c.(136-138)GTC>GTT	p.V46V		NM_001736	NP_001727	P21730	C5AR_HUMAN	complement component 5 receptor 1	46	Helical; Name=1; (Potential).				activation of MAPK activity|activation of phospholipase C activity|cellular defense response|elevation of cytosolic calcium ion concentration|immune response|sensory perception of chemical stimulus	integral to plasma membrane	C5a anaphylatoxin receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_cancers(25;2e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000267)|OV - Ovarian serous cystadenocarcinoma(262;0.000618)|Epithelial(262;0.0142)|GBM - Glioblastoma multiforme(486;0.0242)		TCTTTGCAGTCGTCTTCCTGG	0.552													9	106	---	---	---	---	PASS
TPRX1	284355	broad.mit.edu	37	19	48305217	48305217	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:48305217G>T	uc002php.1	-	2	1122	c.1051C>A	c.(1051-1053)CCT>ACT	p.P351T		NM_198479	NP_940881	Q8N7U7	TPRX1_HUMAN	tetra-peptide repeat homeobox	351						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(25;3.02e-09)|all_epithelial(76;7e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000241)|all cancers(93;0.00036)|Epithelial(262;0.0127)|GBM - Glioblastoma multiforme(486;0.048)		GTGAAGTGAGGGAATAACTGG	0.433													48	86	---	---	---	---	PASS
KLK1	3816	broad.mit.edu	37	19	51326992	51326992	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:51326992C>A	uc002ptk.1	-	1	52	c.13G>T	c.(13-15)GTT>TTT	p.V5F	KLK1_uc010ycg.1_RNA	NM_002257	NP_002248	P06870	KLK1_HUMAN	kallikrein 1 preproprotein	5					proteolysis	nucleus	serine-type endopeptidase activity				0		all_neural(266;0.0199)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00399)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGGCACAGAACCAGGAACCAC	0.637													4	68	---	---	---	---	PASS
SIGLEC5	8778	broad.mit.edu	37	19	52130831	52130831	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:52130831C>A	uc002pxe.2	-	6	1305	c.1166G>T	c.(1165-1167)GGG>GTG	p.G389V		NM_003830	NP_003821	O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5 precursor	389	Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			skin(2)|breast(1)|central_nervous_system(1)	4		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		GGCCCAGGGCCCAGCTGAGCT	0.662													11	42	---	---	---	---	PASS
MIR526A2	574486	broad.mit.edu	37	19	54230232	54230232	+	RNA	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:54230232G>A	hsa-mir-526a-2|MI0003168	+			c.57G>A			MIR518E_hsa-mir-518e|MI0003169_5'Flank																	0						CATCCTTTCAGAGGGTTACTC	0.423													21	109	---	---	---	---	PASS
PTPRH	5794	broad.mit.edu	37	19	55699514	55699514	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:55699514C>T	uc002qjq.2	-	13	2480	c.2407G>A	c.(2407-2409)GAA>AAA	p.E803K	PTPRH_uc010esv.2_Missense_Mutation_p.E625K|uc002qjr.2_5'Flank	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	803	Cytoplasmic (Potential).				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		GCGAAGTCTTCAGCTGGGATG	0.493													20	180	---	---	---	---	PASS
ZNF835	90485	broad.mit.edu	37	19	57175239	57175239	+	Missense_Mutation	SNP	T	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:57175239T>A	uc010ygo.1	-	2	1394	c.1394A>T	c.(1393-1395)GAG>GTG	p.E465V	ZNF835_uc010ygn.1_Missense_Mutation_p.E443V	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						GTAGGGCCGCTCGCCCGTGTG	0.667													6	78	---	---	---	---	PASS
ZSCAN1	284312	broad.mit.edu	37	19	58549470	58549470	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:58549470C>T	uc002qrc.1	+	3	513	c.266C>T	c.(265-267)GCG>GTG	p.A89V	ZSCAN1_uc002qra.1_Missense_Mutation_p.A89V|ZSCAN1_uc002qrb.1_Missense_Mutation_p.A89V	NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	89	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		TTCCTGGGCGCGCTGCCCAGC	0.692													6	17	---	---	---	---	PASS
ZSCAN1	284312	broad.mit.edu	37	19	58564993	58564993	+	Missense_Mutation	SNP	C	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr19:58564993C>G	uc002qrc.1	+	6	1048	c.801C>G	c.(799-801)CAC>CAG	p.H267Q		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	267					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CCCTCAAGCACACCAAAGGTG	0.622													24	43	---	---	---	---	PASS
NINL	22981	broad.mit.edu	37	20	25443158	25443158	+	Missense_Mutation	SNP	T	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr20:25443158T>A	uc002wux.1	-	20	3517	c.3443A>T	c.(3442-3444)CAA>CTA	p.Q1148L	NINL_uc010gdn.1_Missense_Mutation_p.Q799L	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	1148	Potential.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						CTGGGATAATTGATCCTTGTA	0.388													16	141	---	---	---	---	PASS
KIF3B	9371	broad.mit.edu	37	20	30898587	30898587	+	Missense_Mutation	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr20:30898587G>A	uc002wxq.2	+	2	1174	c.1007G>A	c.(1006-1008)CGT>CAT	p.R336H	KIF3B_uc010ztv.1_Missense_Mutation_p.R336H|KIF3B_uc010ztw.1_Missense_Mutation_p.R336H	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	336	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TATGCCAACCGTGCCAAAAAC	0.532													10	77	---	---	---	---	PASS
PTPRT	11122	broad.mit.edu	37	20	40944572	40944572	+	Missense_Mutation	SNP	C	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr20:40944572C>G	uc002xkg.2	-	12	2114	c.1930G>C	c.(1930-1932)GAG>CAG	p.E644Q	PTPRT_uc010ggj.2_Missense_Mutation_p.E644Q	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	644	Extracellular (Potential).|Fibronectin type-III 4.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GAAAAGCACTCAATAATGTCA	0.522													31	64	---	---	---	---	PASS
SPO11	23626	broad.mit.edu	37	20	55908750	55908750	+	Silent	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr20:55908750C>A	uc002xye.2	+	4	435	c.342C>A	c.(340-342)ATC>ATA	p.I114I	SPO11_uc002xyf.2_Silent_p.I76I	NM_012444	NP_036576	Q9Y5K1	SPO11_HUMAN	meiotic recombination protein SPO11 isoform a	114					female gamete generation|reciprocal meiotic recombination	chromosome|nucleus	ATP binding|DNA binding|hydrolase activity			breast(2)|skin(1)	3	Lung NSC(12;0.0066)|all_lung(29;0.0188)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.73e-14)|Epithelial(14;9.02e-10)|all cancers(14;9.31e-09)			CAGCTCTAATCCTTAAAATAT	0.259								Editing_and_processing_nucleases					6	44	---	---	---	---	PASS
PCK1	5105	broad.mit.edu	37	20	56140805	56140805	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr20:56140805C>A	uc002xyn.3	+	10	1977	c.1814C>A	c.(1813-1815)CCC>CAC	p.P605H	PCK1_uc010zzm.1_Missense_Mutation_p.P288H	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	605					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			GCCGACCTCCCCTGTGAAATC	0.458													19	52	---	---	---	---	PASS
ZNF831	128611	broad.mit.edu	37	20	57829620	57829620	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr20:57829620G>T	uc002yan.2	+	5	4856	c.4856G>T	c.(4855-4857)GGA>GTA	p.G1619V		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1619						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					CAGGTATCTGGATTAATCACT	0.488													7	101	---	---	---	---	PASS
SYCP2	10388	broad.mit.edu	37	20	58441392	58441392	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr20:58441392C>T	uc002yaz.2	-	40	4415	c.4276G>A	c.(4276-4278)GAA>AAA	p.E1426K		NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	1426					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			GAATCTTTTTCAAAATTCTCC	0.229													15	89	---	---	---	---	PASS
DIDO1	11083	broad.mit.edu	37	20	61513663	61513663	+	Silent	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr20:61513663C>T	uc002ydr.1	-	16	3909	c.3645G>A	c.(3643-3645)CGG>CGA	p.R1215R	DIDO1_uc002yds.1_Silent_p.R1215R	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1215					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GAAGTCGGGTCCGCTTTTCGT	0.498													38	209	---	---	---	---	PASS
DIDO1	11083	broad.mit.edu	37	20	61528077	61528077	+	Silent	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr20:61528077C>A	uc002ydr.1	-	7	2124	c.1860G>T	c.(1858-1860)GCG>GCT	p.A620A	DIDO1_uc002yds.1_Silent_p.A620A|DIDO1_uc002ydt.1_Silent_p.A620A|DIDO1_uc002ydu.1_Silent_p.A620A	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	620					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CAGCCGTTGCCGCTGCAGGTG	0.642													95	73	---	---	---	---	PASS
GMEB2	26205	broad.mit.edu	37	20	62221642	62221642	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr20:62221642C>T	uc002yfp.1	-	9	1872	c.1393G>A	c.(1393-1395)GGT>AGT	p.G465S	GMEB2_uc002yfo.1_Missense_Mutation_p.G387S|GMEB2_uc002yfq.1_Missense_Mutation_p.G465S	NM_012384	NP_036516	Q9UKD1	GMEB2_HUMAN	glucocorticoid modulatory element binding	465					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|metal ion binding				0	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;4.79e-09)|all cancers(9;2.76e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.0114)			ACCGTGCTACCGTCCTGCACG	0.682													9	81	---	---	---	---	PASS
RBM11	54033	broad.mit.edu	37	21	15599595	15599595	+	Missense_Mutation	SNP	A	G	G			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr21:15599595A>G	uc002yjo.3	+	5	869	c.827A>G	c.(826-828)AAG>AGG	p.K276R	RBM11_uc002yjn.3_Missense_Mutation_p.K162R|RBM11_uc002yjp.3_Missense_Mutation_p.K162R	NM_144770	NP_658983	P57052	RBM11_HUMAN	RNA binding motif protein 11	276							nucleotide binding|RNA binding				0				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		CGAAAGTCTAAGAAGAAGAAA	0.333													35	83	---	---	---	---	PASS
USP25	29761	broad.mit.edu	37	21	17198684	17198684	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr21:17198684G>T	uc002yjy.1	+	13	1683	c.1466G>T	c.(1465-1467)AGC>ATC	p.S489I	USP25_uc011aby.1_Missense_Mutation_p.S489I|USP25_uc002yjz.1_Missense_Mutation_p.S489I|USP25_uc010gla.1_Intron	NM_013396	NP_037528	Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	489					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)|liver(2)	5				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		ACATTACCAAGGTAAAAAGTA	0.378													23	121	---	---	---	---	PASS
TIAM1	7074	broad.mit.edu	37	21	32638720	32638720	+	Missense_Mutation	SNP	T	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr21:32638720T>A	uc002yow.1	-	5	1041	c.569A>T	c.(568-570)CAA>CTA	p.Q190L	TIAM1_uc011adk.1_Missense_Mutation_p.Q190L|TIAM1_uc011adl.1_Missense_Mutation_p.Q190L|TIAM1_uc002yox.1_Intron	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	190					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						TAAATGTTCTTGGCTCAGATC	0.552													23	113	---	---	---	---	PASS
KLHL22	84861	broad.mit.edu	37	22	20819555	20819555	+	Silent	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr22:20819555C>A	uc002zsl.1	-	4	811	c.702G>T	c.(700-702)CTG>CTT	p.L234L	KLHL22_uc011ahr.1_Silent_p.L91L|KLHL22_uc002zsm.1_Silent_p.L234L	NM_032775	NP_116164	Q53GT1	KLH22_HUMAN	kelch-like	234					cell division	Cul3-RING ubiquitin ligase complex				lung(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GGGGCTCGTGCAGCGAGATCT	0.607													12	33	---	---	---	---	PASS
LOC96610	96610	broad.mit.edu	37	22	23247194	23247194	+	RNA	SNP	T	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr22:23247194T>A	uc011aim.1	+	373		c.15997T>A			uc002zws.2_Intron					Parts of antibodies, mostly variable regions.												0						GGGACCAAGCTGACCGTCCTA	0.547													13	127	---	---	---	---	PASS
MYO18B	84700	broad.mit.edu	37	22	26317325	26317325	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr22:26317325G>T	uc003abz.1	+	34	5716	c.5466G>T	c.(5464-5466)GAG>GAT	p.E1822D	MYO18B_uc003aca.1_Missense_Mutation_p.E1703D|MYO18B_uc010guy.1_Missense_Mutation_p.E1704D|MYO18B_uc010guz.1_Missense_Mutation_p.E1702D|MYO18B_uc011aka.1_Missense_Mutation_p.E976D|MYO18B_uc011akb.1_Missense_Mutation_p.E1335D	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1822	Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GCACCATGGAGGATGGCAAGA	0.572													3	12	---	---	---	---	PASS
C22orf33	339669	broad.mit.edu	37	22	37387317	37387317	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr22:37387317C>A	uc003aqf.2	-	6	892	c.746G>T	c.(745-747)GGG>GTG	p.G249V	C22orf33_uc003aqe.2_Missense_Mutation_p.G164V	NM_001163857	NP_001157329	O43247	EAN57_HUMAN	hypothetical protein LOC339669 isoform 1	249											0						GTGCCACCGCCCTACAGCGAG	0.498													24	74	---	---	---	---	PASS
MEI1	150365	broad.mit.edu	37	22	42172159	42172159	+	Silent	SNP	G	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr22:42172159G>A	uc003baz.1	+	21	2623	c.2598G>A	c.(2596-2598)CTG>CTA	p.L866L	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|MEI1_uc011apd.1_RNA|MEI1_uc003bbb.1_Silent_p.L252L|MEI1_uc003bbc.1_Silent_p.L234L|MEI1_uc010gym.1_Silent_p.L234L|MEI1_uc003bbd.1_Silent_p.L109L|MEI1_uc010gyn.1_RNA|MEI1_uc003bbe.1_RNA	NM_152513	NP_689726	Q5TIA1	MEI1_HUMAN	meiosis defective 1	866							binding			central_nervous_system(1)|skin(1)	2						TGATTAGCCTGAGGACCTTCC	0.547													9	52	---	---	---	---	PASS
FAM9A	171482	broad.mit.edu	37	X	8768140	8768140	+	Missense_Mutation	SNP	G	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chrX:8768140G>T	uc004csg.2	-	2	184	c.73C>A	c.(73-75)CAG>AAG	p.Q25K		NM_174951	NP_777611	Q8IZU1	FAM9A_HUMAN	family with sequence similarity 9, member A	25						nucleolus					0		Hepatocellular(5;0.219)				GTGGCCCCCTGGGCGGCCGTA	0.642													11	13	---	---	---	---	PASS
DMD	1756	broad.mit.edu	37	X	32662322	32662322	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chrX:32662322C>T	uc004dda.1	-	11	1502	c.1258G>A	c.(1258-1260)GTA>ATA	p.V420I	DMD_uc004dcz.2_Missense_Mutation_p.V297I|DMD_uc004dcy.1_Missense_Mutation_p.V416I|DMD_uc004ddb.1_Missense_Mutation_p.V412I|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_Missense_Mutation_p.V412I|DMD_uc010ngp.1_Intron|DMD_uc010ngq.1_Intron|MIR548F5_hsa-mir-548f-5|MI0006378_5'Flank	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	420	Spectrin 1.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TGCTCTTGTACTTCAGTTTCT	0.388													10	45	---	---	---	---	PASS
CCNB3	85417	broad.mit.edu	37	X	50055568	50055568	+	Missense_Mutation	SNP	G	T	T	rs149508623	byFrequency	TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chrX:50055568G>T	uc004dox.3	+	7	3657	c.3359G>T	c.(3358-3360)AGC>ATC	p.S1120I	CCNB3_uc004doy.2_Missense_Mutation_p.S1120I|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Missense_Mutation_p.S12I	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	1120					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					GATGAGGACAGCAGTGATCCA	0.388													22	72	---	---	---	---	PASS
XIST	7503	broad.mit.edu	37	X	73066488	73066488	+	RNA	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chrX:73066488C>A	uc004ebm.1	-	1		c.6101G>T				NR_001564				Homo sapiens cDNA: FLJ21545 fis, clone COL06195.												0						GTGGGCACTTCCTGCTGGAAG	0.468													12	34	---	---	---	---	PASS
BRWD3	254065	broad.mit.edu	37	X	79932487	79932487	+	Missense_Mutation	SNP	C	T	T			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chrX:79932487C>T	uc004edt.2	-	41	5293	c.5030G>A	c.(5029-5031)GGA>GAA	p.G1677E	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Missense_Mutation_p.G1273E|BRWD3_uc004edp.2_Missense_Mutation_p.G1506E|BRWD3_uc004edq.2_Missense_Mutation_p.G1273E|BRWD3_uc010nmj.1_Missense_Mutation_p.G1273E|BRWD3_uc004edr.2_Missense_Mutation_p.G1347E|BRWD3_uc004eds.2_Missense_Mutation_p.G1273E|BRWD3_uc004edu.2_Missense_Mutation_p.G1347E|BRWD3_uc004edv.2_Missense_Mutation_p.G1273E|BRWD3_uc004edw.2_Missense_Mutation_p.G1273E|BRWD3_uc004edx.2_Missense_Mutation_p.G1273E|BRWD3_uc004edy.2_Missense_Mutation_p.G1273E|BRWD3_uc004edz.2_Missense_Mutation_p.G1347E|BRWD3_uc004eea.2_Missense_Mutation_p.G1347E|BRWD3_uc004eeb.2_Missense_Mutation_p.G1273E|uc004edn.1_5'Flank	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1677	Gly-rich.									ovary(4)	4						ACCCCATCTTCCCCATCTGCC	0.259													9	86	---	---	---	---	PASS
CPXCR1	53336	broad.mit.edu	37	X	88009035	88009035	+	Missense_Mutation	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chrX:88009035C>A	uc004efd.3	+	3	879	c.620C>A	c.(619-621)CCC>CAC	p.P207H	CPXCR1_uc004efc.3_Missense_Mutation_p.P207H	NM_033048	NP_149037	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	207						intracellular	zinc ion binding			ovary(3)	3						TACTACCGTCCCCTCACTGAG	0.423													8	27	---	---	---	---	PASS
PCDH19	57526	broad.mit.edu	37	X	99657567	99657567	+	Silent	SNP	C	A	A			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chrX:99657567C>A	uc010nmz.2	-	3	4247	c.2571G>T	c.(2569-2571)GGG>GGT	p.G857G	PCDH19_uc004efw.3_Silent_p.G810G|PCDH19_uc004efx.3_Silent_p.G810G	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	857	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						GCTGCTGGGGCCCCTGGCTGT	0.557													8	13	---	---	---	---	PASS
SPRY3	10251	broad.mit.edu	37	X	155003874	155003874	+	Missense_Mutation	SNP	G	T	T	rs150318681		TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chrX:155003874G>T	uc004fnq.1	+	2	795	c.341G>T	c.(340-342)CGA>CTA	p.R114L	SPRY3_uc010nvl.1_Intron	NM_005840	NP_005831	O43610	SPY3_HUMAN	sprouty homolog 3	114					multicellular organismal development|regulation of signal transduction	cytoplasm|membrane					0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TCCATCATCCGAACCCAACCT	0.547													12	64	---	---	---	---	PASS
ABCA12	26154	broad.mit.edu	37	2	215854167	215854167	+	Frame_Shift_Del	DEL	A	-	-			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr2:215854167delA	uc002vew.2	-	26	3935	c.3715delT	c.(3715-3717)TACfs	p.Y1239fs	ABCA12_uc002vev.2_Frame_Shift_Del_p.Y921fs|ABCA12_uc010zjn.1_Frame_Shift_Del_p.Y166fs	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1239					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GGGGAGGTGTACATATTTTCC	0.408													114	52	---	---	---	---	
PACS1	55690	broad.mit.edu	37	11	65838059	65838061	+	In_Frame_Del	DEL	GCA	-	-	rs75352646		TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chr11:65838059_65838061delGCA	uc001oha.1	+	1	236_238	c.102_104delGCA	c.(100-105)CCGCAG>CCG	p.Q40del	PACS1_uc001ogz.1_In_Frame_Del_p.Q40del	NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	40	Gly-rich.|Poly-Gln.				interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding			ovary(6)	6						agccgccgccgcagcagcagcag	0.606													6	3	---	---	---	---	
BTK	695	broad.mit.edu	37	X	100630267	100630267	+	Frame_Shift_Del	DEL	G	-	-			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chrX:100630267delG	uc004ehg.2	-	2	199	c.6delC	c.(4-6)GCCfs	p.A2fs	BTK_uc010nnn.2_Frame_Shift_Del_p.A2fs|BTK_uc010nno.2_Frame_Shift_Del_p.A36fs|BTK_uc004ehi.2_Frame_Shift_Del_p.A2fs	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	2					calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						GAATCACTGCGGCCATAGCTT	0.468									Agammaglobulinemia_X-linked				75	36	---	---	---	---	
TCEAL5	340543	broad.mit.edu	37	X	102529354	102529354	+	Frame_Shift_Del	DEL	C	-	-			TCGA-70-6722-01A-11D-1817-08	TCGA-70-6722-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	e81f1bb5-2d06-44b3-998a-e7a0b818467c	01aa61e4-b97b-41c8-b57f-10234623dc94	g.chrX:102529354delC	uc004ejz.1	-	3	433	c.138delG	c.(136-138)GGGfs	p.G46fs		NM_001012979	NP_001012997	Q5H9L2	TCAL5_HUMAN	transcription elongation factor A (SII)-like 5	46	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(1)|breast(1)	2						attctgtcttcccctccatgt	0.114													17	12	---	---	---	---