Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HDLBP	3069	broad.mit.edu	37	2	242202218	242202218	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr2:242202218C>A	ENST00000391975.1	-	5	585	c.358G>T	c.(358-360)Gcc>Tcc	p.A120S	HDLBP_ENST00000391976.2_Missense_Mutation_p.A120S|HDLBP_ENST00000427183.2_Missense_Mutation_p.A156S|HDLBP_ENST00000310931.4_Missense_Mutation_p.A120S	NM_203346.3	NP_976221.1	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	120					cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(7)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(11)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		TGGTCTTTGGCCAAAGACAGC	0.478000													39	60					2.19489e-29	3.0637e-29	1	1	0
NELL1	4745	broad.mit.edu	37	11	21581913	21581913	+	Silent	SNP	T	T	C			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr11:21581913T>C	ENST00000298925.5	+	18	2202	c.2049T>C	c.(2047-2049)tcT>tcC	p.S683S	NELL1_ENST00000357134.5_Silent_p.S655S|NELL1_ENST00000325319.5_Silent_p.S598S|NELL1_ENST00000529218.1_Intron|NELL1_ENST00000532434.1_Silent_p.S608S			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	655	VWFC 3.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						ACAGGTGTTCTGTCTGCTCCT	0.542000													11	40					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38266439	38266439	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr13:38266439C>A	ENST00000379705.3	-	4	1788	c.931G>T	c.(931-933)Gca>Tca	p.A311S	TRPC4_ENST00000379673.2_Missense_Mutation_p.A311S|TRPC4_ENST00000379679.1_Missense_Mutation_p.A138S|TRPC4_ENST00000426868.2_Missense_Mutation_p.A311S|TRPC4_ENST00000447043.1_Missense_Mutation_p.A311S|TRPC4_ENST00000355779.2_Missense_Mutation_p.A311S|TRPC4_ENST00000338947.5_Missense_Mutation_p.A138S|TRPC4_ENST00000379681.3_Missense_Mutation_p.A311S|TRPC4_ENST00000358477.2_Missense_Mutation_p.A311S			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	311					axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		CAGCGAGATGCCAGCAGCTGT	0.448000													6	14					0.217242	0.218328	1	1	0
COL4A5	1287	broad.mit.edu	37	X	107923922	107923922	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chrX:107923922G>T	ENST00000328300.6	+	45	4200	c.3956G>T	c.(3955-3957)cGg>cTg	p.R1319L	COL4A5_ENST00000361603.2_Missense_Mutation_p.R1313L	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	1313	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						AATCCTGGCCGGCCGGGTCTC	0.418000									Alport syndrome with Diffuse Leiomyomatosis				20	17					8.10497e-08	9.15224e-08	1	1	0
EXD3	54932	broad.mit.edu	37	9	140289766	140289766	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr9:140289766C>T	ENST00000340951.4	-	2	239	c.44G>A	c.(43-45)cGc>cAc	p.R15H	EXD3_ENST00000475006.1_5'UTR|EXD3_ENST00000342129.4_5'UTR|EXD3_ENST00000465160.2_Missense_Mutation_p.R15H|EXD3_ENST00000479452.1_Missense_Mutation_p.R15H	NM_017820.3	NP_060290.3	Q8N9H8	MUT7_HUMAN	exonuclease 3'-5' domain containing 3	15					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)	12						CATGCGGTGGCGCTCGCCAGC	0.687000													4	50					0	0	1	0	0
WWP1	11059	broad.mit.edu	37	8	87439919	87439919	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr8:87439919A>G	ENST00000517970.1	+	11	1512	c.1205A>G	c.(1204-1206)cAt>cGt	p.H402R	WWP1_ENST00000265428.4_Missense_Mutation_p.H402R|WWP1_ENST00000341922.2_Missense_Mutation_p.H272R|WWP1_ENST00000349423.2_Missense_Mutation_p.H184R	NM_007013.3	NP_008944.1	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase 1	402	WW 2.				central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(9)|liver(4)|lung(10)|prostate(2)|urinary_tract(1)	31						TATGTGGATCATAACACCAGA	0.388000													68	149					0	0	1	0	0
OR14A16	284532	broad.mit.edu	37	1	247978703	247978703	+	Missense_Mutation	SNP	A	A	C			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr1:247978703A>C	ENST00000357627.1	-	1	328	c.329T>G	c.(328-330)cTg>cGg	p.L110R		NM_001001966.1	NP_001001966.1	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A, member 16	110					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(32)|skin(2)|stomach(1)	45						GAGGAGGAGCAGCTCTGCAGA	0.473000													18	128					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	36007510	36007510	+	Nonsense_Mutation	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chrX:36007510G>T	ENST00000297866.5	+	16	2854	c.2788G>T	c.(2788-2790)Gaa>Taa	p.E930*		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	930										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						AGAAGAAGGAGAATTTATTCT	0.383000													39	15					1.04594e-18	1.37408e-18	1	1	0
FMN2	56776	broad.mit.edu	37	1	240370748	240370748	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr1:240370748C>A	ENST00000319653.9	+	5	2866	c.2636C>A	c.(2635-2637)cCa>cAa	p.P879Q		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	879	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GTGCCTCCCCCACCTCCCCCT	0.602000													30	143					8.16721e-17	1.03246e-16	1	1	0
ERC2	26059	broad.mit.edu	37	3	55733405	55733405	+	Splice_Site	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr3:55733405C>A	ENST00000288221.6	-	16	3103		c.e16+1			NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2							cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		ATGAAACTGACCTGGTCCGGA	0.433000													50	150					9.40368e-32	1.32178e-31	1	1	0
IARS2	55699	broad.mit.edu	37	1	220273896	220273896	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr1:220273896G>T	ENST00000366922.1	+	3	570	c.239G>T	c.(238-240)gGc>gTc	p.G80V	IARS2_ENST00000302637.5_Missense_Mutation_p.G152V			Q9NSE4	SYIM_HUMAN	isoleucyl-tRNA synthetase 2, mitochondrial	152					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			NS(1)|breast(1)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(17)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	TTTGTGCCCGGCTGGGATTGT	0.343000													41	49					9.73076e-26	1.33053e-25	1	1	0
AMOTL1	154810	broad.mit.edu	37	11	94599178	94599178	+	Missense_Mutation	SNP	A	A	C			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr11:94599178A>C	ENST00000433060.2	+	11	2474	c.2333A>C	c.(2332-2334)aAa>aCa	p.K778T	AMOTL1_ENST00000317837.9_Intron|AMOTL1_ENST00000317829.8_Missense_Mutation_p.K728T	NM_130847.2	NP_570899.1	Q8IY63	AMOL1_HUMAN	angiomotin like 1	778						cytoplasm|tight junction	identical protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(2)	36		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				CGATCTCGTAAAGATGCCGGG	0.478000													13	42					0	0	1	0	0
KIAA0907	22889	broad.mit.edu	37	1	155887393	155887393	+	Missense_Mutation	SNP	T	T	G			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr1:155887393T>G	ENST00000368320.3	-	11	1362	c.1337A>C	c.(1336-1338)cAg>cCg	p.Q446P	KIAA0907_ENST00000368321.3_Missense_Mutation_p.Q446P			Q7Z7F0	K0907_HUMAN	KIAA0907	446	Pro-rich.									breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|urinary_tract(1)	21	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			gggctggggctggggctgggg	0.567000													8	54					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664606	22664606	+	RNA	SNP	A	A	G			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr22:22664606A>G	ENST00000426066.1	+	0	787					NR_027293.1																						GTCTTCATGCAAACTTGGTAT	0.398000													3	16					0	0	1	0	0
OR5W2	390148	broad.mit.edu	37	11	55682056	55682056	+	Translation_Start_Site	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr11:55682056C>T	ENST00000344514.1	-	1	2	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_001001960.1	NP_001001960.1	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W, member 2	1					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(28)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						TTTCCCAGTCCATTCTTCCTT	0.343000													26	35					0	0	1	0	0
C19orf26	255057	broad.mit.edu	37	19	1230954	1230954	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr19:1230954C>T	ENST00000590083.1	-	9	1592	c.1300G>A	c.(1300-1302)Gga>Aga	p.G434R	C19orf26_ENST00000382477.2_Intron|C19orf26_ENST00000215376.6_Missense_Mutation_p.G428R			Q8N350	DOS_HUMAN	chromosome 19 open reading frame 26	253						integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAGTGAGTCCGCCTCTGGGA	0.731000										HNSCC(14;0.022)			41	15					0	0	1	0	0
CFHR3	10878	broad.mit.edu	37	1	196762482	196762482	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr1:196762482A>G	ENST00000367425.4	+	6	924	c.832A>G	c.(832-834)Aat>Gat	p.N278D	CFHR3_ENST00000391985.3_Missense_Mutation_p.N217D	NM_021023.5	NP_066303.2			complement factor H-related 3											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	18						CATGAATAAAAATAACATAAA	0.269000													17	102					0	0	1	0	0
POTEA	340441	broad.mit.edu	37	8	43152486	43152486	+	RNA	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr8:43152486C>A	ENST00000522175.2	+	0	474							Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(27)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						TGGCACTGATCCAAATCTTCC	0.393000													48	85					6.34439e-16	7.97014e-16	1	1	0
FOXA3	3171	broad.mit.edu	37	19	46375619	46375619	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr19:46375619C>T	ENST00000302177.2	+	2	553	c.356C>T	c.(355-357)cCg>cTg	p.P119L		NM_004497.2	NP_004488.2	P55318	FOXA3_HUMAN	forkhead box A3	119					brain development|cellular glucose homeostasis|cellular response to starvation|chromatin modification|embryo development|endocrine pancreas development|negative regulation of cell proliferation|neural plate anterior/posterior regionalization|neuron fate specification|positive regulation of hepatocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)|prostate(1)	13		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00453)|GBM - Glioblastoma multiforme(486;0.0518)|Epithelial(262;0.236)		GCCAAGCCACCGTATTCCTAT	0.627000													30	84					0	0	1	0	0
WDR35	57539	broad.mit.edu	37	2	20174334	20174334	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr2:20174334G>A	ENST00000345530.3	-	7	746	c.631C>T	c.(631-633)Cat>Tat	p.H211Y	WDR35_ENST00000281405.4_Missense_Mutation_p.H211Y|WDR35_ENST00000416055.2_5'UTR	NM_001006657.1	NP_001006658.1	Q9P2L0	WDR35_HUMAN	WD repeat domain 35	211										breast(1)|endometrium(5)|kidney(8)|large_intestine(8)|lung(16)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGGTACCAATGAATTCCAGCA	0.368000													23	30					0	0	1	0	0
SAMSN1	64092	broad.mit.edu	37	21	15870823	15870823	+	Nonsense_Mutation	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr21:15870823C>A	ENST00000285670.2	-	8	1237	c.1063G>T	c.(1063-1065)Gaa>Taa	p.E355*	SAMSN1_ENST00000400564.1_Nonsense_Mutation_p.E119*|SAMSN1_ENST00000400566.1_Nonsense_Mutation_p.E287*|SAMSN1_ENST00000463807.1_5'UTR	NM_001256370.1	NP_001243299.1	Q9NSI8	SAMN1_HUMAN	SAM domain, SH3 domain and nuclear localization signals 1	287					negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	24				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		TCTGGGTTTTCAATATTTAAT	0.363000													37	21					2.42023e-17	3.09851e-17	1	1	0
OR5J2	282775	broad.mit.edu	37	11	55945001	55945001	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr11:55945001G>A	ENST00000312298.1	+	1	908	c.908G>A	c.(907-909)aGg>aAg	p.R303K		NM_001005492.1	NP_001005492.1	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J, member 2	303					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	44	Esophageal squamous(21;0.00693)					GCAGTGAAAAGGGCCATAGAA	0.388000													15	49					0	0	1	0	0
KREMEN1	83999	broad.mit.edu	37	22	29517411	29517411	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr22:29517411C>T	ENST00000400338.2	+	4	472	c.419C>T	c.(418-420)aCg>aTg	p.T140M	KREMEN1_ENST00000400335.4_Missense_Mutation_p.T140M|KREMEN1_ENST00000327813.5_Missense_Mutation_p.T140M|KREMEN1_ENST00000407188.1_Missense_Mutation_p.T138M			Q96MU8	KREM1_HUMAN	kringle containing transmembrane protein 1	138	WSC.				cell communication|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane|membrane fraction	protein binding			breast(1)|endometrium(3)|large_intestine(2)|lung(8)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	20						ACCAGTAAAACGTCCAACAAA	0.403000													30	43					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103405969	103405969	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr1:103405969G>T	ENST00000358392.2	-	43	3651	c.3334C>A	c.(3334-3336)Cct>Act	p.P1112T	COL11A1_ENST00000353414.4_Missense_Mutation_p.P1061T|COL11A1_ENST00000370096.3_Missense_Mutation_p.P1100T|COL11A1_ENST00000512756.1_Missense_Mutation_p.P984T	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1100	Triple-helical region.		Missing (in STL2).		collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CTCCCTGCAGGCCCTTGGGGA	0.468000													25	10					2.21704e-12	2.62132e-12	1	1	0
GSTA2	2939	broad.mit.edu	37	6	52622776	52622776	+	Splice_Site	SNP	C	C	G			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr6:52622776C>G	ENST00000493422.1	-	2	126		c.e2-1			NM_000846.4	NP_000837.3	P09210	GSTA2_HUMAN	glutathione S-transferase alpha 2						glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Lung NSC(77;0.118)				Aminophenazone(DB01424)|Amsacrine(DB00276)|Busulfan(DB01008)|Chlorambucil(DB00291)|Chloroquine(DB00608)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Ethacrynic acid(DB00903)|Glutathione(DB00143)|Mechlorethamine(DB00888)|Praziquantel(DB01058)|Vitamin E(DB00163)	TTCTCTAAGCCtgagtgaatg	0.433000													19	49					0	0	1	0	0
HPSE	10855	broad.mit.edu	37	4	84216552	84216552	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr4:84216552G>A	ENST00000405413.2	-	13	1713	c.1577C>T	c.(1576-1578)gCt>gTt	p.A526V	HPSE_ENST00000513463.1_Missense_Mutation_p.A468V|HPSE_ENST00000512196.1_Missense_Mutation_p.A452V|HPSE_ENST00000311412.5_Missense_Mutation_p.A526V	NM_006665.5	NP_006656.2	Q9Y251	HPSE_HUMAN	heparanase	526					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	20		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	ATATGAGAAAGCTGGCAAGCC	0.388000													51	82					0	0	1	0	0
FAM83C	128876	broad.mit.edu	37	20	33874903	33874903	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr20:33874903C>T	ENST00000374408.3	-	4	1775	c.1679G>A	c.(1678-1680)cGa>cAa	p.R560Q		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	560										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			ACCCAGGGCTCGGGACAGGAG	0.662000													18	39					0	0	1	0	0
TMTC1	83857	broad.mit.edu	37	12	29786199	29786199	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr12:29786199C>A	ENST00000256062.5	-	6	1158	c.685G>T	c.(685-687)Gac>Tac	p.D229Y	TMTC1_ENST00000551659.1_Missense_Mutation_p.D399Y|TMTC1_ENST00000319685.8_5'UTR|TMTC1_ENST00000552618.1_Missense_Mutation_p.D399Y|TMTC1_ENST00000381224.2_Missense_Mutation_p.D291Y|TMTC1_ENST00000539277.1_Missense_Mutation_p.D337Y	NM_175861.3	NP_787057.2	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat containing 1	337						integral to membrane	binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(17)|lung(45)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					ACCTGCCAGTCATAGCACAGG	0.498000													96	45					1.29119e-40	1.85378e-40	1	1	0
KLHL21	9903	broad.mit.edu	37	1	6655607	6655607	+	Missense_Mutation	SNP	C	C	T	rs147251785		TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr1:6655607C>T	ENST00000377663.3	-	3	1621	c.1438G>A	c.(1438-1440)Gct>Act	p.A480T	KLHL21_ENST00000377658.4_Missense_Mutation_p.A480T|KLHL21_ENST00000463043.1_Missense_Mutation_p.A113T|KLHL21_ENST00000467612.1_Missense_Mutation_p.A113T			Q9UJP4	KLH21_HUMAN	kelch-like family member 21	480					anaphase|cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|cytoplasm|polar microtubule				central_nervous_system(1)|endometrium(1)|kidney(1)|lung(3)|prostate(2)	8	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.36e-07)|COAD - Colon adenocarcinoma(227;1.4e-05)|Kidney(185;4.95e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000528)|KIRC - Kidney renal clear cell carcinoma(229;0.000927)|STAD - Stomach adenocarcinoma(132;0.0172)|READ - Rectum adenocarcinoma(331;0.0644)		TCCACCTCAGCGGAGTCATCC	0.587000													10	17					0	0	1	0	0
PTPRE	5791	broad.mit.edu	37	10	129847916	129847916	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr10:129847916C>T	ENST00000254667.3	+	6	685	c.406C>T	c.(406-408)Cgg>Tgg	p.R136W	PTPRE_ENST00000306042.5_Missense_Mutation_p.R78W|PTPRE_ENST00000471218.1_Missense_Mutation_p.S134L|PTPRE_ENST00000419012.2_Missense_Mutation_p.R136W|PTPRE_ENST00000430713.2_Missense_Mutation_p.R136W	NM_006504.4	NP_006495.1	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	136	Tyrosine-protein phosphatase 1.				negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	22		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				CAAGCAGTTTCGGGAGGAGTT	0.562000													15	52					0	0	1	0	0
ERC1	23085	broad.mit.edu	37	12	1137214	1137214	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr12:1137214G>C	ENST00000397203.2	+	2	551	c.145G>C	c.(145-147)Ggc>Cgc	p.G49R	ERC1_ENST00000355446.5_Missense_Mutation_p.G49R|ERC1_ENST00000360905.4_Missense_Mutation_p.G49R|ERC1_ENST00000543086.3_Missense_Mutation_p.G49R|ERC1_ENST00000546231.2_Missense_Mutation_p.G49R|ERC1_ENST00000589028.1_Missense_Mutation_p.G49R			Q8IUD2	RB6I2_HUMAN	ELKS/RAB6-interacting/CAST family member 1	49					I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			NS(1)|breast(2)|cervix(2)|endometrium(2)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	38	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			TGTTGGAGGTGGCAGTGGGAA	0.527000													99	74					0	0	1	0	0
LIN9	286826	broad.mit.edu	37	1	226455689	226455689	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr1:226455689C>T	ENST00000328205.5	-	8	1378	c.833G>A	c.(832-834)gGa>gAa	p.G278E	LIN9_ENST00000481685.1_Missense_Mutation_p.G243E|LIN9_ENST00000366801.1_Missense_Mutation_p.G227E	NM_173083.3	NP_775106.2	Q5TKA1	LIN9_HUMAN	lin-9 homolog (C. elegans)	262	Sufficient for interaction with RB1.				cell cycle|DNA replication	nucleoplasm				breast(3)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		GGTATGGGTTCCAAGCCCTGT	0.353000													14	69					0	0	1	0	0
MYOG	4656	broad.mit.edu	37	1	203053044	203053044	+	Silent	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr1:203053044G>T	ENST00000241651.4	-	3	743	c.669C>A	c.(667-669)ccC>ccA	p.P223P		NM_002479.4	NP_002470.2	P15173	MYOG_HUMAN	myogenin (myogenic factor 4)	223					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|skin(2)|urinary_tract(1)	12						AATCTCAGTTGGGCATGGTTT	0.587000													5	10					0.0215528	0.0217694	1	1	0
SLC44A2	57153	broad.mit.edu	37	19	10747091	10747091	+	Silent	SNP	G	G	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr19:10747091G>A	ENST00000586078.1	+	15	1435	c.1326G>A	c.(1324-1326)ctG>ctA	p.L442L	SLC44A2_ENST00000407327.4_Silent_p.L440L|SLC44A2_ENST00000335757.5_Silent_p.L442L	NM_020428.3	NP_065161.3	Q8IWA5	CTL2_HUMAN	solute carrier family 44 (choline transporter), member 2	442					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			NS(1)|breast(3)|endometrium(5)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	ACCGGGCCCTGCTGGGCCTGC	0.627000													57	65					0	0	1	0	0
NIT1	4817	broad.mit.edu	37	1	161088957	161088957	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr1:161088957C>G	ENST00000368008.1	+	3	191	c.132C>G	c.(130-132)tgC>tgG	p.C44W	NIT1_ENST00000392190.5_Missense_Mutation_p.C8W|NIT1_ENST00000368007.4_Missense_Mutation_p.C29W|NIT1_ENST00000368009.2_Missense_Mutation_p.C44W|NIT1_ENST00000496861.1_3'UTR	NM_001185092.1	NP_001172021.1	Q86X76	NIT1_HUMAN	nitrilase 1	44					nitrogen compound metabolic process	mitochondrion	nitrilase activity			NS(1)|breast(2)|endometrium(2)|large_intestine(3)|lung(3)|prostate(1)	12	all_cancers(52;3.39e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			CTTCCTCCTGCGAACTGCCCC	0.522000													26	140					0	0	1	0	0
CXADRP3	440224	broad.mit.edu	37	18	14478711	14478711	+	RNA	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr18:14478711G>T	ENST00000581457.1	-	0	1197					NR_024076.1																						ACCATGAAGTGGGCATTTTCT	0.368000													7	40					1.06961e-07	1.20107e-07	1	1	0
OTOP1	133060	broad.mit.edu	37	4	4228226	4228226	+	Silent	SNP	G	G	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr4:4228226G>A	ENST00000296358.4	-	1	390	c.366C>T	c.(364-366)cgC>cgT	p.R122R		NM_177998.1	NP_819056.1	Q7RTM1	OTOP1_HUMAN	otopetrin 1	122					biomineral tissue development	extracellular space|integral to membrane		p.R122R(2)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|liver(4)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TGTCCTTGAGGCGGAAGAGGC	0.716000													3	11					0	0	1	0	0
DSCR4	10281	broad.mit.edu	37	21	39493332	39493332	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr21:39493332C>A	ENST00000328264.3	-	1	122	c.18G>T	c.(16-18)ttG>ttT	p.L6F	DSCR4_ENST00000398948.1_Missense_Mutation_p.L6F	NM_005867.2	NP_005858.1	P56555	DSCR4_HUMAN	Down syndrome critical region gene 4	6										large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(1)	6						catctctcgtcaagatgatta	0.488000													11	20					2.27111e-07	2.53607e-07	1	1	0
XIRP2	129446	broad.mit.edu	37	2	168102371	168102371	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr2:168102371C>A	ENST00000409195.1	+	9	4558	c.4469C>A	c.(4468-4470)gCt>gAt	p.A1490D	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.A1490D|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.A1268D|XIRP2_ENST00000409756.2_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1315					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GTTAAGCAGGCTGTGTGGCTT	0.393000													71	69					3.07281e-33	4.34955e-33	1	1	0
YME1L1	10730	broad.mit.edu	37	10	27423040	27423040	+	Silent	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr10:27423040G>T	ENST00000326799.3	-	8	1022	c.874C>A	c.(874-876)Cga>Aga	p.R292R	YME1L1_ENST00000463270.1_5'UTR|YME1L1_ENST00000376016.3_Silent_p.R235R|YME1L1_ENST00000375972.3_Silent_p.R202R	NM_139312.2	NP_647473.1	Q96TA2	YMEL1_HUMAN	YME1-like 1 ATPase	292					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23						AGACGGGTTCGCCTTAGGGAA	0.323000													17	45					7.21436e-19	9.54005e-19	1	1	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr12:25398285C>A	ENST00000311936.3	-	2	225	c.34G>T	c.(34-36)Ggt>Tgt	p.G12C	KRAS_ENST00000256078.4_Missense_Mutation_p.G12C|KRAS_ENST00000557334.1_Missense_Mutation_p.G12C|KRAS_ENST00000556131.1_Missense_Mutation_p.G12C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			31	21					1.88708e-17	2.43144e-17	1	1	0
DYSF	8291	broad.mit.edu	37	2	71797812	71797812	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr2:71797812C>T	ENST00000258104.3	+	29	3392	c.3115C>T	c.(3115-3117)Cgg>Tgg	p.R1039W	DYSF_ENST00000409366.1_Missense_Mutation_p.R1040W|DYSF_ENST00000394120.2_Missense_Mutation_p.R1040W|DYSF_ENST00000409744.1_Missense_Mutation_p.R1026W|DYSF_ENST00000429174.2_Missense_Mutation_p.R1039W|DYSF_ENST00000409582.3_Missense_Mutation_p.R1056W|DYSF_ENST00000410020.3_Missense_Mutation_p.R1057W|DYSF_ENST00000410041.1_Missense_Mutation_p.R1057W|DYSF_ENST00000413539.2_Missense_Mutation_p.R1070W|DYSF_ENST00000409762.1_Missense_Mutation_p.R1056W|DYSF_ENST00000409651.1_Missense_Mutation_p.R1071W	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1039	Arg-rich.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						CACACACCGACGGCGGCGCTG	0.637000													15	33					0	0	1	0	0
PDCD6IP	10015	broad.mit.edu	37	3	33896716	33896716	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr3:33896716T>A	ENST00000307296.3	+	15	2461	c.2084T>A	c.(2083-2085)gTt>gAt	p.V695D	PDCD6IP_ENST00000457054.2_Missense_Mutation_p.V700D			Q8WUM4	PDC6I_HUMAN	programmed cell death 6 interacting protein	695	Interaction with EIAV p9.|Self-association.				apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|skin(1)|stomach(1)	23						AGTGATATAGTTTTTGCACGG	0.318000													29	97					0	0	1	0	0
IRF2BPL	64207	broad.mit.edu	37	14	77491933	77491933	+	Missense_Mutation	SNP	T	T	A	rs141239534	byFrequency	TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr14:77491933T>A	ENST00000238647.3	-	1	3101	c.2203A>T	c.(2203-2205)Agc>Tgc	p.S735C		NM_024496.3	NP_078772.1	Q9H1B7	I2BPL_HUMAN	interferon regulatory factor 2 binding protein-like	735	Cys-rich.					nucleus				endometrium(2)|kidney(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	11						AATTTGTGGCTGGGGACGGAA	0.587000													39	59					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51902186	51902186	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr17:51902186G>T	ENST00000268919.4	+	1	1948	c.1792G>T	c.(1792-1794)Gtt>Ttt	p.V598F		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	598					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						GATTGAAGAGGTTGAAACATT	0.418000													12	153					2.80697e-09	3.22401e-09	1	1	0
PPFIA3	8541	broad.mit.edu	37	19	49641581	49641581	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr19:49641581C>T	ENST00000334186.4	+	16	2322	c.1973C>T	c.(1972-1974)tCc>tTc	p.S658F	PPFIA3_ENST00000602351.1_Missense_Mutation_p.S658F	NM_003660.2	NP_003651.1	O75145	LIPA3_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	658						cell surface|cytoplasm	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(16)|pancreas(1)|prostate(1)|skin(4)|urinary_tract(1)	35		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		CTGCCCCCCTCCCTCACCACC	0.677000													31	15					0	0	1	0	0
SOGA3	387104	broad.mit.edu	37	6	127797442	127797442	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr6:127797442C>T	ENST00000556132.1	-	6	2593	c.1729G>A	c.(1729-1731)Gga>Aga	p.G577R	SOGA3_ENST00000525778.1_Missense_Mutation_p.G577R|SOGA3_ENST00000481848.2_Missense_Mutation_p.G577R|SOGA3_ENST00000368268.2_Missense_Mutation_p.G577R|SOGA3_ENST00000465909.2_Missense_Mutation_p.G577R	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	577						integral to membrane											GGAGGGCCTCCGGCTTCTCCT	0.532000													11	108					0	0	1	0	0
HAS2	3037	broad.mit.edu	37	8	122641181	122641181	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr8:122641181A>T	ENST00000303924.4	-	2	937	c.400T>A	c.(400-402)Ttc>Atc	p.F134I		NM_005328.2	NP_005319.1	Q92819	HAS2_HUMAN	hyaluronan synthase 2	134						integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(19)|ovary(5)|skin(1)	38	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			ACTTCACTGAAGATGTCCATC	0.428000													57	442					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33588493	33588493	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr2:33588493G>T	ENST00000404816.2	+	29	4660	c.4307G>T	c.(4306-4308)tGc>tTc	p.C1436F	LTBP1_ENST00000407925.1_Missense_Mutation_p.C1110F|LTBP1_ENST00000418533.2_Missense_Mutation_p.C1068F|LTBP1_ENST00000272273.5_Missense_Mutation_p.C334F|LTBP1_ENST00000390003.4_Missense_Mutation_p.C1111F|LTBP1_ENST00000404525.1_Missense_Mutation_p.C1057F|LTBP1_ENST00000402934.1_Missense_Mutation_p.C1055F|LTBP1_ENST00000354476.3_Missense_Mutation_p.C1437F			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1436	EGF-like 15; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CAAGAAATCTGCAAAAATGGT	0.383000													45	57					2.95478e-19	3.93318e-19	1	1	0
MTA2	9219	broad.mit.edu	37	11	62362104	62362104	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr11:62362104C>A	ENST00000278823.2	-	16	1965	c.1576G>T	c.(1576-1578)Gcc>Tcc	p.A526S	MTA2_ENST00000527204.1_Missense_Mutation_p.A353S|MTA2_ENST00000524902.1_Missense_Mutation_p.A353S	NM_004739.3	NP_004730.2	O94776	MTA2_HUMAN	metastasis associated 1 family, member 2	526					chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	26						GGTGCCTGGGCCACTGGAAAA	0.522000													14	65					4.93089e-13	5.97054e-13	1	1	0
DOCK6	57572	broad.mit.edu	37	19	11353740	11353740	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr19:11353740A>T	ENST00000294618.7	-	13	1486	c.1475T>A	c.(1474-1476)gTg>gAg	p.V492E		NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	492					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						CGCACCAGTCACAGGACGTAG	0.582000											OREG0025252	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	57					0	0	1	0	0
GK2	2712	broad.mit.edu	37	4	80327718	80327718	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr4:80327718G>T	ENST00000358842.3	-	1	1654	c.1637C>A	c.(1636-1638)gCa>gAa	p.A546E		NM_033214.2	NP_149991.2	Q14410	GLPK2_HUMAN	glycerol kinase 2	546					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			autonomic_ganglia(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	39						GATATATCTTGCTCCAATTAG	0.393000													14	62					0.000151284	0.00016089	1	1	0
NOTCH1	4851	broad.mit.edu	37	9	139399812	139399812	+	Silent	SNP	G	G	A	rs61751540	by1000genomes	TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr9:139399812G>A	ENST00000277541.6	-	25	4611	c.4536C>T	c.(4534-4536)gcC>gcT	p.A1512A		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	1512					aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		AGAGGCAGCCGGCTGAGTTGC	0.597000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			3	15					0	0	1	0	0
FAM71C	196472	broad.mit.edu	37	12	100042229	100042229	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr12:100042229G>T	ENST00000324341.1	+	1	699	c.277G>T	c.(277-279)Gct>Tct	p.A93S	ANKS1B_ENST00000329257.7_Intron|ANKS1B_ENST00000547776.2_Intron|ANKS1B_ENST00000547010.1_Intron	NM_153364.3	NP_699195.1	Q8NEG0	FA71C_HUMAN	family with sequence similarity 71, member C	93										breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				OV - Ovarian serous cystadenocarcinoma(2;0.00733)|Epithelial(2;0.0385)|all cancers(2;0.19)		CCGACCAGCTGCTGTCTGTGA	0.552000													24	159					1.10513e-12	1.32221e-12	1	1	0
NKX2-4	644524	broad.mit.edu	37	20	21376892	21376892	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr20:21376892C>T	ENST00000351817.4	-	2	1350	c.722G>A	c.(721-723)cGg>cAg	p.R241Q		NM_033176.1	NP_149416.1	Q9H2Z4	NKX24_HUMAN	NK2 homeobox 4	241					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(2)|upper_aerodigestive_tract(1)	3						CATCTTGTACCGGTGGTTCTG	0.692000													9	17					0	0	1	0	0
CEP170P1	645455	broad.mit.edu	37	4	119475217	119475217	+	RNA	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr4:119475217C>A	ENST00000412784.2	+	0	928					NR_003135.2																						TAGAGTCAACCCTGATGGGGA	0.408000													5	15					0.000602214	0.000623944	1	1	0
GALNT15	117248	broad.mit.edu	37	3	16250090	16250090	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr3:16250090G>A	ENST00000339732.5	+	4	1495	c.992G>A	c.(991-993)gGg>gAg	p.G331E	GALNT15_ENST00000437509.1_Missense_Mutation_p.G331E	NM_054110.4	NP_473451.3			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15									p.G331V(1)									CTGCAGCGTGGGGTGTTGGAC	0.527000													40	127					0	0	1	0	0
NHS	4810	broad.mit.edu	37	X	17750171	17750171	+	Nonsense_Mutation	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chrX:17750171G>T	ENST00000380060.3	+	8	4818	c.4480G>T	c.(4480-4482)Gaa>Taa	p.E1494*	NHS_ENST00000398097.3_Nonsense_Mutation_p.E1338*	NM_198270.2	NP_938011.1	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome (congenital cataracts and dental anomalies)	1494						nucleus				breast(5)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(26)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	71	Hepatocellular(33;0.183)					CACATCCAATGAAGAGTTTAA	0.488000													5	86					0.000602214	0.000623944	1	1	0
POTEA	340441	broad.mit.edu	37	8	43197450	43197450	+	RNA	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr8:43197450C>A	ENST00000522175.2	+	0	1203							Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(27)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GCTCATTGAACAACTCAAAAT	0.363000													21	107					8.34094e-07	9.06231e-07	1	1	0
IRF2BPL	64207	broad.mit.edu	37	14	77492110	77492110	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr14:77492110T>C	ENST00000238647.3	-	1	2924	c.2026A>G	c.(2026-2028)Aac>Gac	p.N676D		NM_024496.3	NP_078772.1	Q9H1B7	I2BPL_HUMAN	interferon regulatory factor 2 binding protein-like	676						nucleus				endometrium(2)|kidney(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	11						AGGTCCCCGTTACGTGATGCC	0.672000													21	42					0	0	1	0	0
CYP11B2	1585	broad.mit.edu	37	8	143994079	143994079	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr8:143994079C>T	ENST00000323110.2	-	8	1267	c.1265G>A	c.(1264-1266)cGg>cAg	p.R422Q		NM_000498.3	NP_000489.3	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 2	422					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(22)|ovary(3)|upper_aerodigestive_tract(3)	39	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GGGATTATACCGCTCAGGCCT	0.622000									Familial Hyperaldosteronism type I				44	109					0	0	1	0	0
CPA4	51200	broad.mit.edu	37	7	129962506	129962506	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr7:129962506A>T	ENST00000222482.4	+	11	1284	c.1256A>T	c.(1255-1257)aAc>aTc	p.N419I	CPA4_ENST00000493259.1_Missense_Mutation_p.N315I|CPA4_ENST00000445470.2_Missense_Mutation_p.N386I	NM_016352.3	NP_057436.2	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4	419					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Melanoma(18;0.0435)					GTGCGGGACAACCTCTACTAG	0.547000													48	48					0	0	1	0	0
CNTN3	5067	broad.mit.edu	37	3	74418510	74418510	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr3:74418510A>T	ENST00000263665.6	-	7	803	c.776T>A	c.(775-777)aTt>aAt	p.I259N		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	259	Ig-like C2-type 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TCTCCAATTAATCTGAGGTAT	0.383000													23	63					0	0	1	0	0
DDX25	29118	broad.mit.edu	37	11	125788526	125788526	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr11:125788526C>T	ENST00000263576.6	+	10	1197	c.1042C>T	c.(1042-1044)Cgt>Tgt	p.R348C	DDX25_ENST00000525943.1_3'UTR|RP11-680F20.9_ENST00000533033.2_RNA	NM_013264.4	NP_037396.3	Q9UHL0	DDX25_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 25	348	Helicase C-terminal.				mRNA export from nucleus|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|nucleus	ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)	10	all_hematologic(175;0.177)	Breast(109;0.0021)|all_lung(97;0.0203)|Lung NSC(97;0.0203)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.14e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.046)		TACATAGACTCGTCGAAACGC	0.537000													9	33					0	0	1	0	0
NDRG4	65009	broad.mit.edu	37	16	58528891	58528891	+	Silent	SNP	G	G	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr16:58528891G>A	ENST00000394282.4	+	3	563	c.156G>A	c.(154-156)ttG>ttA	p.L52L	NDRG4_ENST00000394279.2_Silent_p.L32L|NDRG4_ENST00000258187.5_Silent_p.L32L	NM_001130487.1	NP_001123959.1	Q9ULP0	NDRG4_HUMAN	NDRG family member 4	0					cell differentiation|cell growth|multicellular organismal development|response to stress	cytoplasm				breast(1)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	11						CCTTCCTCTTGGCTGCAGACA	0.632000													6	21					0	0	1	0	0
MOSPD3	64598	broad.mit.edu	37	7	100211254	100211254	+	Nonsense_Mutation	SNP	G	G	T	rs137921044	byFrequency	TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr7:100211254G>T	ENST00000393950.2	+	3	718	c.436G>T	c.(436-438)Gga>Tga	p.G146*	MOSPD3_ENST00000223054.4_Nonsense_Mutation_p.G146*|MOSPD3_ENST00000424091.2_Nonsense_Mutation_p.G136*|MOSPD3_ENST00000379527.2_Nonsense_Mutation_p.G146*	NM_023948.4	NP_076438.1	O75425	MSPD3_HUMAN	motile sperm domain containing 3	146						integral to membrane	structural molecule activity			breast(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	16	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					TGAGCTTCAGGGACAGCCAGA	0.627000													23	73					6.44725e-10	7.44769e-10	1	1	0
MRPL38	64978	broad.mit.edu	37	17	73900774	73900774	+	Translation_Start_Site	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr17:73900774G>T	ENST00000409963.3	-	0	540				RP11-552F3.12_ENST00000587556.1_3'UTR|MRPL38_ENST00000585475.1_Intron|MRPL38_ENST00000309352.3_Missense_Mutation_p.L32M			Q96DV4	RM38_HUMAN	mitochondrial ribosomal protein L38							actin cytoskeleton|mitochondrion|ribosome				ovary(1)|pancreas(1)|prostate(2)|skin(1)	5			all cancers(21;0.000154)|Epithelial(20;0.000156)|BRCA - Breast invasive adenocarcinoma(9;0.00936)|LUSC - Lung squamous cell carcinoma(166;0.154)			ATCGGCCCCAGCGGGGGTGTC	0.721000													3	12					0.000602214	0.000623944	1	1	0
TENM2	57451	broad.mit.edu	37	5	167674260	167674260	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr5:167674260G>A	ENST00000519204.1	+	26	6071	c.5953G>A	c.(5953-5955)Gtc>Atc	p.V1985I	TENM2_ENST00000403607.2_Missense_Mutation_p.V1930I|TENM2_ENST00000518659.1_Missense_Mutation_p.V2106I|TENM2_ENST00000545108.1_Missense_Mutation_p.V2105I|TENM2_ENST00000520394.1_Missense_Mutation_p.V1867I					teneurin transmembrane protein 2																		CATCAAGCCCGTCATAAGTGA	0.488000													35	116					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236917318	236917318	+	Silent	SNP	T	T	G			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr1:236917318T>G	ENST00000366578.4	+	16	2077	c.1911T>G	c.(1909-1911)cgT>cgG	p.R637R	ACTN2_ENST00000542672.1_Silent_p.R637R|ACTN2_ENST00000546208.1_Silent_p.R131R	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	637					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CTAACGAGCGTCTGAGGCGCC	0.602000													38	104					0	0	1	0	0
NHS	4810	broad.mit.edu	37	X	17750172	17750172	+	Missense_Mutation	SNP	A	A	C			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chrX:17750172A>C	ENST00000380060.3	+	8	4819	c.4481A>C	c.(4480-4482)gAa>gCa	p.E1494A	NHS_ENST00000398097.3_Missense_Mutation_p.E1338A	NM_198270.2	NP_938011.1	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome (congenital cataracts and dental anomalies)	1494						nucleus				breast(5)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(26)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	71	Hepatocellular(33;0.183)					ACATCCAATGAAGAGTTTAAG	0.483000													5	85					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98760934	98760934	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr10:98760934C>A	ENST00000266058.4	-	37	4785	c.4540G>T	c.(4540-4542)Gat>Tat	p.D1514Y	ARHGAP19-SLIT1_ENST00000453547.2_3'UTR|SLIT1_ENST00000371070.4_3'UTR	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	1514	CTCK.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		GAGGTCCCATCGCTGCACTCA	0.672000													28	96					4.87955e-14	5.94418e-14	1	1	0
CLCN7	1186	broad.mit.edu	37	16	1509122	1509122	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr16:1509122C>A	ENST00000382745.4	-	7	1266	c.661G>T	c.(661-663)Gtg>Ttg	p.V221L	CLCN7_ENST00000262318.8_Missense_Mutation_p.V197L|CLCN7_ENST00000448525.1_Missense_Mutation_p.V197L	NM_001287.5	NP_001278.1	P51798	CLCN7_HUMAN	chloride channel, voltage-sensitive 7	221						integral to membrane|lysosomal membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(3)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|skin(2)	24		Hepatocellular(780;0.0893)				AGCCGCACCACGTGGGGGATC	0.657000													8	23					0.000157383	0.000166495	1	1	0
MRPL38	64978	broad.mit.edu	37	17	73900770	73900770	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr17:73900770C>A	ENST00000309352.3	-	2	635	c.98G>T	c.(97-99)gGg>gTg	p.G33V	RP11-552F3.12_ENST00000587556.1_3'UTR|MRPL38_ENST00000585475.1_Intron|MRPL38_ENST00000409963.3_5'UTR	NM_032478.3	NP_115867.2	Q96DV4	RM38_HUMAN	mitochondrial ribosomal protein L38	33						actin cytoskeleton|mitochondrion|ribosome				ovary(1)|pancreas(1)|prostate(2)|skin(1)	5			all cancers(21;0.000154)|Epithelial(20;0.000156)|BRCA - Breast invasive adenocarcinoma(9;0.00936)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGGCATCGGCCCCAGCGGGGG	0.726000													3	13					0.014758	0.0149816	1	1	0
CYP39A1	51302	broad.mit.edu	37	6	46605583	46605583	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr6:46605583C>A	ENST00000275016.2	-	4	824	c.621G>T	c.(619-621)ttG>ttT	p.L207F		NM_016593.3	NP_057677.2	Q9NYL5	CP39A_HUMAN	cytochrome P450, family 39, subfamily A, polypeptide 1	207					bile acid biosynthetic process|bile acid catabolic process|digestion|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	24-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity		EIF3K/CYP39A1(2)	NS(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|skin(2)	21						GACACTCTGGCAACTGGGACC	0.328000													4	75					0.00909568	0.00928036	1	1	0
FAM214B	80256	broad.mit.edu	37	9	35105221	35105221	+	Silent	SNP	G	G	C			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr9:35105221G>C	ENST00000378561.1	-	8	4669	c.1614C>G	c.(1612-1614)ccC>ccG	p.P538P	FAM214B_ENST00000378557.1_Silent_p.P538P|FAM214B_ENST00000322813.5_Silent_p.P538P|FAM214B_ENST00000378566.1_Silent_p.P233P|FAM214B_ENST00000603301.1_Silent_p.P538P|FAM214B_ENST00000378554.2_Intron|FAM214B_ENST00000488109.2_Silent_p.P538P|FAM214B_ENST00000605244.1_Silent_p.P538P			Q7L5A3	K1539_HUMAN	family with sequence similarity 214, member B	538						nucleus											CTGGCAATCAGGGCAAAGGTG	0.552000													13	15					0	0	1	0	0
WDR36	134430	broad.mit.edu	37	5	110428002	110428002	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr5:110428002G>T	ENST00000506538.2	+	1	589	c.16G>T	c.(16-18)Ggc>Tgc	p.G6C	WDR36_ENST00000513710.2_Missense_Mutation_p.G6C	NM_139281.2	NP_644810.1	Q8NI36	WDR36_HUMAN	WD repeat domain 36	6					response to stimulus|rRNA processing|visual perception	small-subunit processome				cervix(1)|endometrium(9)|kidney(4)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		TTGCACTGAGGGCAGTCTCCG	0.592000													25	62					8.24728e-16	1.02963e-15	1	1	0
TMEM225	338661	broad.mit.edu	37	11	123756029	123756029	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr11:123756029T>A	ENST00000375026.2	-	1	320	c.104A>T	c.(103-105)gAa>gTa	p.E35V		NM_001013743.1	NP_001013765.1	Q6GV28	TM225_HUMAN	transmembrane protein 225	35						integral to membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(12)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	28						TGAAATCAATTCAACCCATTT	0.428000													5	96					0	0	1	0	0
UNC13D	201294	broad.mit.edu	37	17	73840388	73840388	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr17:73840388G>A	ENST00000207549.4	-	1	410	c.31C>T	c.(31-33)Cgc>Tgc	p.R11C	UNC13D_ENST00000412096.2_Missense_Mutation_p.R11C	NM_199242.2	NP_954712.1	Q70J99	UN13D_HUMAN	unc-13 homolog D (C. elegans)	11					positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			AAGGGAGGGCGCTGCTGCGGA	0.617000									Familial Hemophagocytic Lymphohistiocytosis				8	21					0	0	1	0	0
RIN3	79890	broad.mit.edu	37	14	93118469	93118469	+	Missense_Mutation	SNP	A	A	T	rs139103248	byFrequency	TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr14:93118469A>T	ENST00000216487.7	+	6	1234	c.1075A>T	c.(1075-1077)Atg>Ttg	p.M359L	RIN3_ENST00000418924.2_3'UTR	NM_024832.3	NP_079108.3	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	359	Pro-rich.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			endometrium(4)|kidney(2)|large_intestine(7)|lung(19)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	36		all_cancers(154;0.0701)				GGAGGAAGCGATGAAGCCAGG	0.682000													21	53					0	0	1	0	0
NFIC	4782	broad.mit.edu	37	19	3425170	3425170	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr19:3425170C>T	ENST00000589123.1	+	3	722	c.602C>T	c.(601-603)aCg>aTg	p.T201M	NFIC_ENST00000443272.2_Missense_Mutation_p.T210M|NFIC_ENST00000395111.3_Missense_Mutation_p.T201M|NFIC_ENST00000586919.1_Intron|NFIC_ENST00000341919.3_Missense_Mutation_p.T210M|NFIC_ENST00000590282.1_Missense_Mutation_p.T210M|NFIC_ENST00000346156.5_Intron	NM_001245005.1|NM_205843.2	NP_001231934.1|NP_995315.1	P08651	NFIC_HUMAN	nuclear factor I/C (CCAAT-binding transcription factor)	210					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.8e-05)|Epithelial(107;2.94e-108)|BRCA - Breast invasive adenocarcinoma(158;0.00154)|STAD - Stomach adenocarcinoma(1328;0.191)		AAGCCCATCACGCTGGGTGAG	0.587000													7	16					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181702135	181702135	+	Silent	SNP	A	A	C			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr1:181702135A>C	ENST00000526775.1	+	19	3021	c.2856A>C	c.(2854-2856)ccA>ccC	p.P952P	CACNA1E_ENST00000357570.5_Silent_p.P922P|CACNA1E_ENST00000360108.3_Silent_p.P952P|CACNA1E_ENST00000367567.4_Silent_p.P578P|CACNA1E_ENST00000358338.5_Silent_p.P903P|CACNA1E_ENST00000367573.2_Silent_p.P971P|CACNA1E_ENST00000367570.1_Silent_p.P971P	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	971					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CCAAGGAGCCAACGATCCAAG	0.562000													12	64					0	0	1	0	0
FAM110B	90362	broad.mit.edu	37	8	59059512	59059512	+	Silent	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr8:59059512C>T	ENST00000361488.3	+	5	1603	c.723C>T	c.(721-723)gcC>gcT	p.A241A	FAM110B_ENST00000520369.1_Intron	NM_147189.2	NP_671722.1	Q8TC76	F110B_HUMAN	family with sequence similarity 110, member B	241						microtubule organizing center|mitochondrion|nucleus		p.A241A(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(9)|skin(2)	26		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				CCCCCGAGGCCGACCCTGTGG	0.622000													20	135					0	0	1	0	0
PABPN1	8106	broad.mit.edu	37	14	23793490	23793490	+	Silent	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr14:23793490C>T	ENST00000397276.2	+	6	886	c.873C>T	c.(871-873)cgC>cgT	p.R291R	BCL2L2-PABPN1_ENST00000553781.1_Silent_p.R318R|PABPN1_ENST00000216727.4_Silent_p.R291R|PABPN1_ENST00000556821.1_Silent_p.R163R|BCL2L2-PABPN1_ENST00000557008.1_Silent_p.R318R|PABPN1_ENST00000557702.1_Silent_p.R163R					poly(A) binding protein, nuclear 1											large_intestine(1)|lung(1)|ovary(2)	4	all_cancers(95;6.69e-06)			GBM - Glioblastoma multiforme(265;0.00643)		CCCGGGGTCGCGTCTACAGGT	0.632000													25	124					0	0	1	0	0
RABEP2	79874	broad.mit.edu	37	16	28922453	28922453	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr16:28922453G>C	ENST00000358201.4	-	6	1530	c.942C>G	c.(940-942)gaC>gaG	p.D314E	RABEP2_ENST00000544477.1_Missense_Mutation_p.D243E|RABEP2_ENST00000357573.6_Intron	NM_024816.2	NP_079092.2	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	314					endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	16						CTTGGAGCTCGTCCCGCTCGC	0.677000													18	48					0	0	1	0	0
OR6C6	283365	broad.mit.edu	37	12	55688658	55688658	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr12:55688658C>T	ENST00000358433.2	-	1	358	c.359G>A	c.(358-360)cGc>cAc	p.R120H		NM_001005493.1	NP_001005493.1	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C, member 6	120					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						GGCAACGTAGCGGTCATAGGA	0.398000													81	47					0	0	1	0	0
MTNR1B	4544	broad.mit.edu	37	11	92714945	92714945	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr11:92714945C>T	ENST00000257068.2	+	2	562	c.556C>T	c.(556-558)Cgc>Tgc	p.R186C		NM_005959.3	NP_005950.1	P49286	MTR1B_HUMAN	melatonin receptor 1B	186					G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	33		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	GTACGACCCACGCATCTATTC	0.617000													5	36					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167228	140167228	+	Silent	SNP	C	C	T	rs143660641		TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr5:140167228C>T	ENST00000504120.2	+	1	1353	c.1353C>T	c.(1351-1353)aaC>aaT	p.N451N	PCDHA1_ENST00000394633.3_Silent_p.N451N|PCDHA1_ENST00000378133.3_Silent_p.N451N	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAATGACAACGCGCCTGCGT	0.677000													31	77					0	0	1	0	0
RNF115	27246	broad.mit.edu	37	1	145663350	145663350	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr1:145663350A>T	ENST00000369291.4	+	4	615	c.411A>T	c.(409-411)agA>agT	p.R137S		NM_014455.2	NP_055270.1	Q9Y4L5	RN115_HUMAN	ring finger protein 115	137					protein autoubiquitination	cytosol	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13						GTCCTGACAGATCTCCAGCTA	0.428000													35	82					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16173332	16173332	+	Silent	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr16:16173332C>T	ENST00000399408.2	+	16	2287	c.2112C>T	c.(2110-2112)atC>atT	p.I704I	ABCC1_ENST00000349029.5_Silent_p.I704I|ABCC1_ENST00000346370.5_Silent_p.I704I|ABCC1_ENST00000345148.5_Silent_p.I704I|ABCC1_ENST00000399410.3_Silent_p.I704I|ABCC1_ENST00000351154.5_Silent_p.I704I			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	704	ABC transporter 1.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	ACGTGGCTATCAAGGTAGGAT	0.592000													7	41					0	0	1	0	0
ADCY2	108	broad.mit.edu	37	5	7690864	7690864	+	Missense_Mutation	SNP	A	A	C			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr5:7690864A>C	ENST00000338316.4	+	5	870	c.781A>C	c.(781-783)Atc>Ctc	p.I261L	ADCY2_ENST00000537121.1_Missense_Mutation_p.I81L|ADCY2_ENST00000513693.1_3'UTR	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	261					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						AGCGGAGATCATCCAGAGGCT	0.562000													4	32					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134073609	134073609	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr4:134073609G>T	ENST00000264360.4	+	1	3140	c.2314G>T	c.(2314-2316)Ggc>Tgc	p.G772C		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	772					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		GACCTGCTGTGGCCGCCAAGC	0.582000													9	43					0.000274275	0.000288635	1	1	0
CLCA4	22802	broad.mit.edu	37	1	87045966	87045966	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr1:87045966C>G	ENST00000370563.3	+	14	2740	c.2698C>G	c.(2698-2700)Ctg>Gtg	p.L900V	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	900						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		TATTTCTACGCTGGTATTGTC	0.358000													10	23					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414269	20414269	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr9:20414269C>G	ENST00000380338.4	-	5	861	c.575G>C	c.(574-576)aGt>aCt	p.S192T	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Missense_Mutation_p.S189T	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	192	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		CTTTGAAAAACTGGTActact	0.502000			T	MLL	ALL								56	101					0	0	1	0	0
DVL3	1857	broad.mit.edu	37	3	183887980	183887980	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr3:183887980G>T	ENST00000313143.3	+	14	1933	c.1685G>T	c.(1684-1686)gGg>gTg	p.G562V	DVL3_ENST00000431765.1_Missense_Mutation_p.G545V|EIF2B5_ENST00000444495.1_Intron	NM_004423.3	NP_004414.3	Q92997	DVL3_HUMAN	dishevelled segment polarity protein 3	562					canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(6)|liver(1)|lung(13)|ovary(1)|prostate(1)	35	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			AGCTACGGCGGGGGCAGCGCC	0.706000													17	18					1.56452e-12	1.86077e-12	1	1	0
MATN4	8785	broad.mit.edu	37	20	43927090	43927090	+	Silent	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr20:43927090C>T	ENST00000537548.1	-	8	1390	c.1146G>A	c.(1144-1146)acG>acA	p.T382T	MATN4_ENST00000372751.4_Silent_p.T233T|MATN4_ENST00000372754.1_Silent_p.T423T|MATN4_ENST00000372756.1_Silent_p.T382T|MATN4_ENST00000360607.5_Silent_p.T341T|MATN4_ENST00000342716.4_Silent_p.T382T|MATN4_ENST00000372753.1_Silent_p.T233T|MATN4_ENST00000353917.5_Silent_p.T300T			O95460	MATN4_HUMAN	matrilin 4	423						extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.0122)				GCCCCACCCGCGTGCCCTCGG	0.637000													18	78					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7637506	7637506	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr17:7637506C>T	ENST00000572933.1	+	6	2094	c.634C>T	c.(634-636)Cgg>Tgg	p.R212W	DNAH2_ENST00000570791.1_Missense_Mutation_p.R212W|DNAH2_ENST00000082259.3_Missense_Mutation_p.R212W|DNAH2_ENST00000389173.2_Missense_Mutation_p.R212W			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	212	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CTTAGACACTCGGTACAAACT	0.532000													2	2					0	0	1	0	0
CCNB3	85417	broad.mit.edu	37	X	50089773	50089773	+	Silent	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chrX:50089773C>A	ENST00000376042.1	+	10	4075	c.3777C>A	c.(3775-3777)ccC>ccA	p.P1259P	CCNB3_ENST00000276014.7_Silent_p.P1259P|CCNB3_ENST00000376038.1_Silent_p.P155P|CCNB3_ENST00000348603.2_Silent_p.P155P			Q8WWL7	CCNB3_HUMAN	cyclin B3	1259					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					TTAACATTCCCATCGCCTACC	0.428000													15	33					7.93312e-07	8.71343e-07	1	1	0
C9orf89	84270	broad.mit.edu	37	9	95875330	95875330	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr9:95875330G>A	ENST00000375464.2	+	6	621	c.493G>A	c.(493-495)Gac>Aac	p.D165N	C9orf89_ENST00000488630.1_3'UTR	NM_032310.3	NP_115686.3	Q96LW7	BINCA_HUMAN	chromosome 9 open reading frame 89	0					negative regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|nucleus	CARD domain binding			endometrium(1)|kidney(1)|lung(3)|ovary(1)|skin(1)	7						TGTCATCATCGACAGACATGT	0.612000													6	10					0	0	1	0	0
CPVL	54504	broad.mit.edu	37	7	29132283	29132283	+	Silent	SNP	G	G	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr7:29132283G>A	ENST00000409850.1	-	10	1144	c.498C>T	c.(496-498)caC>caT	p.H166H	CPVL_ENST00000396276.3_Silent_p.H166H|CPVL_ENST00000265394.5_Silent_p.H166H			Q9H3G5	CPVL_HUMAN	carboxypeptidase, vitellogenic-like	166					proteolysis		protein binding|serine-type carboxypeptidase activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(1)	28						CTGCATATCCGTGGGTATCAT	0.443000													15	42					0	0	1	0	0
JADE1	79960	broad.mit.edu	37	4	129783281	129783281	+	Silent	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr4:129783281C>T	ENST00000226319.6	+	9	1684	c.1404C>T	c.(1402-1404)acC>acT	p.T468T	PHF17_ENST00000512960.1_Silent_p.T468T|PHF17_ENST00000413543.2_Silent_p.T468T|PHF17_ENST00000511647.1_Silent_p.T468T|PHF17_ENST00000452328.2_Silent_p.T456T	NM_199320.2	NP_955352.1	Q6IE81	JADE1_HUMAN		468					apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						CCCTGATCACCCCAAAGAAAG	0.537000													23	56					0	0	1	0	0
SOBP	55084	broad.mit.edu	37	6	107955499	107955499	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr6:107955499C>T	ENST00000317357.5	+	6	2110	c.1451C>T	c.(1450-1452)cCg>cTg	p.P484L		NM_018013.3	NP_060483.3	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog (Drosophila)	484	Pro-rich.						metal ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	26		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		CCGGGCGCCCCGCTGCCGAGT	0.706000													7	2					0	0	1	0	0
DDX10	1662	broad.mit.edu	37	11	108549100	108549100	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr11:108549100G>A	ENST00000526794.1	+	5	628	c.596G>A	c.(595-597)gGt>gAt	p.G199D	DDX10_ENST00000322536.3_Missense_Mutation_p.G199D			Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	199	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(11)|pancreas(1)|prostate(2)	27		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		TGCACACCAGGTCGGCTTCTT	0.353000			T	NUP98	AML*								21	85					0	0	1	0	0
ALMS1P	200420	broad.mit.edu	37	2	73901059	73901059	+	RNA	SNP	G	G	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr2:73901059G>A	ENST00000450720.1	+	0	857					NR_003683.2																						AGCGGGATGCGCTATTCGACA	0.542000													7	10					0	0	1	0	0
CHRNA1	1134	broad.mit.edu	37	2	175618415	175618415	+	Silent	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr2:175618415G>T	ENST00000348749.5	-	6	671	c.594C>A	c.(592-594)atC>atA	p.I198I	AC018890.6_ENST00000442996.1_RNA|CHRNA1_ENST00000409219.1_Silent_p.I198I|CHRNA1_ENST00000261007.5_Silent_p.I223I|CHRNA1_ENST00000409323.1_Silent_p.I198I|CHRNA1_ENST00000409542.1_Silent_p.I116I	NM_000079.3	NP_000070.1	P02708	ACHA_HUMAN	cholinergic receptor, nicotinic, alpha 1 (muscle)	223			G -> S (in SCCMS).		muscle cell homeostasis|neuromuscular junction development|neuromuscular process|neuromuscular synaptic transmission|neuron homeostasis|regulation of action potential in neuron|skeletal muscle contraction|skeletal muscle tissue growth	cell junction|cell surface|neuromuscular junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(3)|prostate(3)|skin(4)	37						GGGACTCCTTGATCACCCACT	0.597000													25	38					9.57634e-11	1.11263e-10	1	1	0
TRIM11	81559	broad.mit.edu	37	1	228582919	228582919	+	Silent	SNP	A	A	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr1:228582919A>T	ENST00000493030.2	-	5	4228	c.519T>A	c.(517-519)ccT>ccA	p.P173P	TRIM11_ENST00000284551.6_Silent_p.P298P|RP11-245P10.8_ENST00000602963.1_RNA|TRIM11_ENST00000460651.1_5'UTR			Q96F44	TRI11_HUMAN	tripartite motif containing 11	298					response to virus	cytoplasm|nucleus	protein binding|zinc ion binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|skin(1)	18		Prostate(94;0.0724)				GGATCAGCTCAGGGTTGGCGG	0.687000													4	15					0	0	1	0	0
CDK11A	728642	broad.mit.edu	37	1	1635300	1635300	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr1:1635300C>A	ENST00000356200.3	-	16	2006	c.1772G>T	c.(1771-1773)gGg>gTg	p.G591V	CDK11A_ENST00000378638.2_Missense_Mutation_p.G591V|CDK11A_ENST00000404249.3_Missense_Mutation_p.G625V|RP1-283E3.8_ENST00000598846.1_RNA|CDK11A_ENST00000378633.1_Missense_Mutation_p.G628V|CDK11A_ENST00000358779.5_Missense_Mutation_p.G615V|CDK11A_ENST00000357760.2_Missense_Mutation_p.G624V					cyclin-dependent kinase 11A											central_nervous_system(1)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(4)|stomach(1)|urinary_tract(1)	18						TTCCGAATTCCCGGGGAACAG	0.572000													14	18					1.49906e-05	1.60272e-05	1	1	0
PLXNA4	91584	broad.mit.edu	37	7	131853219	131853219	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr7:131853219C>T	ENST00000359827.3	-	22	5092	c.4130G>A	c.(4129-4131)aGc>aAc	p.S1377N	PLXNA4_ENST00000321063.4_Missense_Mutation_p.S1377N			Q9HCM2	PLXA4_HUMAN	plexin A4	1377						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CATGGAGAAGCTACGCTGGGA	0.597000													13	63					0	0	1	0	0
GPLD1	2822	broad.mit.edu	37	6	24437512	24437512	+	Missense_Mutation	SNP	C	C	T	rs112686285		TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr6:24437512C>T	ENST00000230036.1	-	21	2136	c.2026G>A	c.(2026-2028)Gtg>Atg	p.V676M		NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	676						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						ACCTTAGACACGTCATCTGAA	0.552000													10	66					0	0	1	0	0
FAM126A	84668	broad.mit.edu	37	7	22999967	22999967	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr7:22999967C>T	ENST00000432176.2	-	10	1131	c.899G>A	c.(898-900)tGt>tAt	p.C300Y	FAM126A_ENST00000409923.1_Missense_Mutation_p.C300Y|FAM126A_ENST00000498833.1_5'UTR	NM_032581.3	NP_115970.2	Q9BYI3	HYCCI_HUMAN	family with sequence similarity 126, member A	300						cytoplasm|membrane	signal transducer activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|urinary_tract(2)	23						AACTTGAATACACCTTGTACC	0.368000													52	125					0	0	1	0	0
GSTM5	2949	broad.mit.edu	37	1	110256075	110256075	+	Silent	SNP	A	A	G	rs2479390	by1000genomes	TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr1:110256075A>G	ENST00000369813.1	+	2	929	c.24A>G	c.(22-24)caA>caG	p.Q8Q	GSTM5_ENST00000369812.5_Silent_p.Q68Q|GSTM5_ENST00000256593.3_Intron			P46439	GSTM5_HUMAN	glutathione S-transferase mu 5	0	GST N-terminal.|Glutathione binding (By similarity).				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity			NS(1)|central_nervous_system(6)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	21		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Colorectal(144;0.0131)|all cancers(265;0.0252)|Epithelial(280;0.0265)|Lung(183;0.0425)|COAD - Colon adenocarcinoma(174;0.0474)|LUSC - Lung squamous cell carcinoma(189;0.228)	Glutathione(DB00143)	TGGTGGCCCAACTGAGCTTCC	0.572000													7	112					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133980142	133980142	+	Silent	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr8:133980142C>T	ENST00000220616.4	+	31	5830	c.5790C>T	c.(5788-5790)gaC>gaT	p.D1930D	TG_ENST00000377869.1_Silent_p.D1873D|TG_ENST00000542445.1_Silent_p.D300D|TG_ENST00000519543.1_Silent_p.D84D	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	1930					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TGTGTGATGACATCATGGAGT	0.532000													10	68					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7551135	7551135	+	Missense_Mutation	SNP	C	C	G	rs143303315		TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr12:7551135C>G	ENST00000313599.3	-	7	1511	c.1454G>C	c.(1453-1455)tGt>tCt	p.C485S	CD163L1_ENST00000416109.2_Missense_Mutation_p.C495S|CD163L1_ENST00000396630.1_Missense_Mutation_p.C485S			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	485	SRCR 5.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						TCTCCCATAACAGGGGCTATG	0.458000													23	130					0	0	1	0	0
SYT15	83849	broad.mit.edu	37	10	46967683	46967683	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr10:46967683A>T	ENST00000374323.3	-	3	1140	c.553T>A	c.(553-555)Tac>Aac	p.Y185N	SYT15_ENST00000503753.1_Missense_Mutation_p.Y132N|SYT15_ENST00000374325.3_Missense_Mutation_p.Y132N|SYT15_ENST00000374321.4_Missense_Mutation_p.Y132N			Q9BQS2	SYT15_HUMAN	synaptotagmin XV	132	C2 1.					integral to membrane|plasma membrane				cervix(1)|endometrium(5)|kidney(2)|lung(5)	13						GGGAACTTGTACAGCTCTGGG	0.622000													16	345					0	0	1	0	0
SEMA3G	56920	broad.mit.edu	37	3	52469787	52469787	+	Silent	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr3:52469787C>T	ENST00000231721.2	-	16	2180	c.2181G>A	c.(2179-2181)gaG>gaA	p.E727E		NM_020163.1	NP_064548.1	Q9NS98	SEM3G_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	727					multicellular organismal development	extracellular region|membrane	receptor activity			kidney(1)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)	18				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		ACCACACGCGCTCACAGTACT	0.677000													19	83					0	0	1	0	0
STK11	6794	broad.mit.edu	37	19	1221228	1221228	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr19:1221228G>T	ENST00000326873.7	+	6	1924	c.751G>T	c.(751-753)Ggt>Tgt	p.G251C		NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	251	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(2)|p.G251R(1)|p.Y246fs*3(1)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		CATCACCACGGGTCTGTACCC	0.587000		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			21	5					6.21321e-17	7.90415e-17	1	1	0
FAM122B	159090	broad.mit.edu	37	X	133922824	133922824	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chrX:133922824G>T	ENST00000370790.1	-	5	1242	c.314C>A	c.(313-315)tCt>tAt	p.S105Y	FAM122B_ENST00000486347.1_Missense_Mutation_p.S105Y|FAM122B_ENST00000493333.1_5'UTR|FAM122B_ENST00000298090.6_Missense_Mutation_p.S124Y|FAM122B_ENST00000343004.5_Missense_Mutation_p.S124Y	NM_001166599.2|NM_145284.5	NP_001160071.1|NP_660327.2	Q7Z309	F122B_HUMAN	family with sequence similarity 122B	105										breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|skin(1)	6	Acute lymphoblastic leukemia(192;0.000127)					TCTCTTAGGAGAATATAATTT	0.393000													21	33					4.96729e-08	5.64082e-08	1	1	0
CNTN1	1272	broad.mit.edu	37	12	41419053	41419053	+	Silent	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr12:41419053C>A	ENST00000551295.2	+	21	2742	c.2625C>A	c.(2623-2625)acC>acA	p.T875T	CNTN1_ENST00000550305.1_3'UTR|CNTN1_ENST00000348761.2_Silent_p.T864T|CNTN1_ENST00000347616.1_Silent_p.T875T	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	875	Fibronectin type-III 3.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TGCCAGACACCCAGTATTTTA	0.507000													66	385					6.8682e-38	9.79084e-38	1	1	0
ZBTB3	79842	broad.mit.edu	37	11	62519805	62519805	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr11:62519805G>C	ENST00000394807.3	-	2	1607	c.1482C>G	c.(1480-1482)caC>caG	p.H494Q		NM_024784.3	NP_079060.1	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	494					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(9)|ovary(2)|prostate(2)	24						GCTCACGTGTGTGCACCGTGG	0.572000													15	44					0	0	1	0	0
CLK3	1198	broad.mit.edu	37	15	74919993	74919993	+	Silent	SNP	G	G	A	rs143391795		TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr15:74919993G>A	ENST00000395066.3	+	9	1931	c.1470G>A	c.(1468-1470)ccG>ccA	p.P490P	CLK3_ENST00000348245.3_3'UTR|CLK3_ENST00000345005.4_Silent_p.P342P|CLK3_ENST00000352989.5_Silent_p.P319P	NM_001130028.1	NP_001123500.1	P49761	CLK3_HUMAN	CDC-like kinase 3	490	Protein kinase.					acrosomal vesicle|nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(2)|stomach(2)|urinary_tract(1)	15						ACTATCGCCCGCCTGAGGTGA	0.547000													35	101					0	0	1	0	0
CDC14B	8555	broad.mit.edu	37	9	99286009	99286009	+	Splice_Site	SNP	T	T	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr9:99286009T>A	ENST00000375241.1	-	10	1398		c.e10-2		CDC14B_ENST00000265659.2_Splice_Site|CDC14B_ENST00000375240.3_Splice_Site|CDC14B_ENST00000375242.3_Splice_Site|CDC14B_ENST00000375236.1_Splice_Site|CDC14B_ENST00000463569.1_Splice_Site	NM_003671.3|NM_033331.2	NP_003662.1|NP_201588.1	O60729	CC14B_HUMAN	cell division cycle 14B						activation of anaphase-promoting complex activity|DNA repair|G2/M transition DNA damage checkpoint	nucleolus|nucleoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)	15		Acute lymphoblastic leukemia(62;0.0559)				CAAGGCCAGCTAGGAAAATAA	0.478000													7	21					0	0	1	0	0
ZNF581	51545	broad.mit.edu	37	19	56156438	56156438	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr19:56156438C>G	ENST00000587252.1	+	2	774	c.501C>G	c.(499-501)caC>caG	p.H167Q	ZNF581_ENST00000270451.5_Missense_Mutation_p.H167Q|ZNF581_ENST00000588537.1_Missense_Mutation_p.H167Q			Q9P0T4	ZN581_HUMAN	zinc finger protein 581	167					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3		Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		GCCGGGTGCACTCTGGGGAAC	0.667000													31	99					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179598558	179598558	+	Silent	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr2:179598558G>T	ENST00000589042.1	-	53	15782	c.15558C>A	c.(15556-15558)acC>acA	p.T5186T	TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Silent_p.T4869T|TTN_ENST00000342992.6_Silent_p.T3942T	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4869	Ig-like 32.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGCTTGCAGGGTAACGGTTT	0.413000													30	109					1.88708e-17	2.43144e-17	1	1	0
PCDH15	65217	broad.mit.edu	37	10	56129019	56129019	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr10:56129019T>A	ENST00000373965.2	-	5	729	c.335A>T	c.(334-336)cAc>cTc	p.H112L	PCDH15_ENST00000395438.1_Missense_Mutation_p.H112L|PCDH15_ENST00000437009.1_Missense_Mutation_p.H112L|PCDH15_ENST00000395440.1_Missense_Mutation_p.H112L|PCDH15_ENST00000395442.1_Missense_Mutation_p.H112L|PCDH15_ENST00000395446.1_Missense_Mutation_p.H112L|PCDH15_ENST00000320301.6_Missense_Mutation_p.H112L|PCDH15_ENST00000395432.2_Missense_Mutation_p.H112L|PCDH15_ENST00000414778.1_Missense_Mutation_p.H117L|PCDH15_ENST00000395430.1_Missense_Mutation_p.H112L|PCDH15_ENST00000373957.3_Missense_Mutation_p.H90L|PCDH15_ENST00000395445.1_Missense_Mutation_p.H112L|PCDH15_ENST00000395433.1_Missense_Mutation_p.H90L|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000373955.1_Missense_Mutation_p.H112L|PCDH15_ENST00000361849.3_Missense_Mutation_p.H112L	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	112	Cadherin 1.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				CACAATGGAGTGTATGTTCAT	0.408000										HNSCC(58;0.16)			14	61					0	0	1	0	0
MBD2	8932	broad.mit.edu	37	18	51750540	51750540	+	Silent	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr18:51750540C>T	ENST00000256429.3	-	1	618	c.390G>A	c.(388-390)ccG>ccA	p.P130P	MBD2_ENST00000583046.1_Silent_p.P130P|MBD2_ENST00000398398.2_Silent_p.P130P	NM_003927.4	NP_003918.1	Q9UBB5	MBD2_HUMAN	methyl-CpG binding domain protein 2	130	Gly-rich.				transcription, DNA-dependent		C2H2 zinc finger domain binding|methyl-CpG binding|satellite DNA binding			breast(1)|large_intestine(3)|lung(2)|prostate(1)|urinary_tract(1)	8				Colorectal(16;0.0212)|READ - Rectum adenocarcinoma(32;0.188)	Hexobarbital(DB01355)	CGCTCCCCGACGGGAAAGGGA	0.806000													5	3					0	0	1	0	0
IFITM3	10410	broad.mit.edu	37	11	320606	320606	+	Missense_Mutation	SNP	G	G	T	rs149004156	by1000genomes	TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr11:320606G>T	ENST00000399808.4	-	1	444	c.208C>A	c.(208-210)Ccc>Acc	p.P70T	IFITM3_ENST00000602735.1_Missense_Mutation_p.P49T|RP11-326C3.11_ENST00000602756.1_RNA|RP11-326C3.11_ENST00000602429.1_RNA|IFITM3_ENST00000526811.1_Missense_Mutation_p.P49T	NM_021034.2	NP_066362.2	Q01628	IFM3_HUMAN	interferon induced transmembrane protein 3	70	Interaction with SPP1.				response to virus|type I interferon-mediated signaling pathway	integral to membrane|plasma membrane		p.P70T(3)		central_nervous_system(7)|endometrium(7)|kidney(2)|large_intestine(1)|lung(1)	18		all_cancers(49;2e-09)|all_epithelial(84;3.36e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;8.85e-28)|Epithelial(43;5.52e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		AGGCAGCAGGGGTTCATGAAG	0.632000													7	129					7.48243e-07	8.26356e-07	1	1	0
GPR155	151556	broad.mit.edu	37	2	175335284	175335284	+	Splice_Site	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr2:175335284C>A	ENST00000392552.2	-	4	1099		c.e4-1		GPR155_ENST00000295500.4_Splice_Site|GPR155_ENST00000392551.2_Splice_Site	NM_001267051.1|NM_152529.6	NP_001253980.1|NP_689742.4	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155						intracellular signal transduction|transmembrane transport	integral to membrane				breast(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	26						CAGCACCAGACTGAAGAAAAA	0.443000													9	36					1.12685e-05	1.21121e-05	1	1	0
PLXNA4	91584	broad.mit.edu	37	7	131878846	131878846	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr7:131878846C>A	ENST00000359827.3	-	14	3793	c.2831G>T	c.(2830-2832)cGg>cTg	p.R944L	PLXNA4_ENST00000321063.4_Missense_Mutation_p.R944L			Q9HCM2	PLXA4_HUMAN	plexin A4	944	IPT/TIG 1.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CTGTGAGGACCGGGCCATGAA	0.592000													19	59					8.34094e-07	9.06231e-07	1	1	0
TLR4	7099	broad.mit.edu	37	9	120475523	120475523	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr9:120475523C>A	ENST00000355622.6	+	3	1218	c.1117C>A	c.(1117-1119)Cca>Aca	p.P373T	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Missense_Mutation_p.P333T	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	373					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						AGTTGATCTACCAAGCCTTGA	0.383000													19	35					3.99206e-14	4.8927e-14	1	1	0
SLC2A3	6515	broad.mit.edu	37	12	8084033	8084033	+	Silent	SNP	G	G	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr12:8084033G>A	ENST00000075120.7	-	4	558	c.318C>T	c.(316-318)tgC>tgT	p.C106C		NM_006931.2	NP_008862.1	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 3	106					carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(14)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30				Kidney(36;0.0866)		GTCCCATAAAGCAGCCACCAG	0.468000													87	59					0	0	1	0	0
SDCCAG8	10806	broad.mit.edu	37	1	243471358	243471358	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr1:243471358C>A	ENST00000366541.3	+	8	926	c.808C>A	c.(808-810)Ctt>Att	p.L270I	SDCCAG8_ENST00000355875.4_Missense_Mutation_p.L227I|SDCCAG8_ENST00000343783.6_Missense_Mutation_p.L125I|SDCCAG8_ENST00000391846.1_Missense_Mutation_p.L270I	NM_006642.3	NP_006633.1	Q86SQ7	SDCG8_HUMAN	serologically defined colon cancer antigen 8	270	Sufficient for homodimerization (By similarity).				establishment of cell polarity|G2/M transition of mitotic cell cycle|tube formation	cell-cell junction|centriole|cytosol	protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_cancers(71;0.000545)|all_epithelial(71;0.000509)|all_lung(81;0.0821)|Ovarian(71;0.0919)|all_neural(11;0.101)|Breast(184;0.218)	all_cancers(173;0.00395)	all cancers(7;1.58e-07)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00392)	COAD - Colon adenocarcinoma(196;0.145)		TAAAGAATTTCTTCTGGCTGC	0.368000													45	237					1.03325e-14	1.28199e-14	1	1	0
PLCZ1	89869	broad.mit.edu	37	12	18854696	18854696	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr12:18854696T>A	ENST00000447925.2	-	8	1142	c.873A>T	c.(871-873)aaA>aaT	p.K291N	PLCZ1_ENST00000541695.1_Missense_Mutation_p.K156N|PLCZ1_ENST00000435379.1_Missense_Mutation_p.K98N|PLCZ1_ENST00000542762.1_5'UTR|PLCZ1_ENST00000266505.7_Missense_Mutation_p.K293N|PLCZ1_ENST00000538330.1_Missense_Mutation_p.K34N|PLCZ1_ENST00000539875.1_Missense_Mutation_p.K100N	NM_033123.2	NP_149114.2	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	293	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					TAACTAATATTTTGAATTTTA	0.318000													4	30					0	0	1	0	0
PRDM2	7799	broad.mit.edu	37	1	14107968	14107968	+	Silent	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr1:14107968C>T	ENST00000235372.7	+	8	4534	c.3678C>T	c.(3676-3678)agC>agT	p.S1226S	PRDM2_ENST00000413440.1_Silent_p.S1025S|PRDM2_ENST00000376048.5_Intron|PRDM2_ENST00000311066.5_Silent_p.S1226S|PRDM2_ENST00000343137.4_Silent_p.S1025S|PRDM2_ENST00000503842.1_Intron|PRDM2_ENST00000505823.1_Intron	NM_012231.4	NP_036363.2	Q13029	PRDM2_HUMAN	PR domain containing 2, with ZNF domain	1226						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(16)|lung(20)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	55	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		AGTTTGAAAGCGGGACTCTGA	0.453000													36	72					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19356206	19356206	+	Missense_Mutation	SNP	G	G	A	rs150818380		TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr19:19356206G>A	ENST00000252575.5	+	13	3620	c.3577G>A	c.(3577-3579)Ggg>Agg	p.G1193R	NCAN_ENST00000538881.1_Missense_Mutation_p.G644R	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	1193	C-type lectin.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			GCATGAAAGCGGGCGCTGGAA	0.557000													25	61					0	0	1	0	0
SLC35D1	23169	broad.mit.edu	37	1	67519653	67519653	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr1:67519653T>A	ENST00000235345.5	-	1	129	c.44A>T	c.(43-45)gAa>gTa	p.E15V		NM_015139.2	NP_055954.1	Q9NTN3	S35D1_HUMAN	solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1	15					chondroitin sulfate biosynthetic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	integral to endoplasmic reticulum membrane	UDP-glucuronic acid transmembrane transporter activity|UDP-N-acetylgalactosamine transmembrane transporter activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(4)	10					Lorazepam(DB00186)	CGCGGGGGCTTCTCCTTTAAC	0.662000													27	15					0	0	1	0	0
XRN1	54464	broad.mit.edu	37	3	142151651	142151651	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr3:142151651T>C	ENST00000264951.4	-	2	277	c.160A>G	c.(160-162)Aga>Gga	p.R54G	XRN1_ENST00000544157.1_5'UTR|XRN1_ENST00000392981.2_Missense_Mutation_p.R54G|XRN1_ENST00000463916.1_Missense_Mutation_p.R54G	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1	54					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						TCTGAAATTCTAAAGTGAACA	0.343000													17	54					0	0	1	0	0
PDZRN3	23024	broad.mit.edu	37	3	73438977	73438977	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr3:73438977C>T	ENST00000263666.4	-	7	1520	c.1406G>A	c.(1405-1407)cGc>cAc	p.R469H	PDZRN3_ENST00000479530.1_Missense_Mutation_p.R186H|PDZRN3_ENST00000462146.2_Missense_Mutation_p.R126H|PDZRN3_ENST00000466348.1_5'UTR|PDZRN3_ENST00000535920.1_Missense_Mutation_p.R191H|PDZRN3_ENST00000466780.1_Missense_Mutation_p.R126H	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	469	PDZ 2.						ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		CTGGATAATGCGGTCTCCTTC	0.473000													13	81					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76535859	76535859	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr17:76535859C>G	ENST00000389840.5	-	18	2760	c.2636G>C	c.(2635-2637)cGc>cCc	p.R879P	DNAH17_ENST00000585328.1_Missense_Mutation_p.R879P					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CAGAGATTTGCGAATGAACTG	0.363000													5	41					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77765957	77765957	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr8:77765957C>G	ENST00000521891.2	+	10	7248	c.6800C>G	c.(6799-6801)aCc>aGc	p.T2267S	ZFHX4_ENST00000518282.1_Missense_Mutation_p.T2241S|ZFHX4_ENST00000050961.6_Missense_Mutation_p.T2222S|ZFHX4_ENST00000455469.2_Missense_Mutation_p.T2222S	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2222						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AATCTGCCTACCCGGGTTATT	0.398000										HNSCC(33;0.089)			20	53					0	0	1	0	0
ITGAV	3685	broad.mit.edu	37	2	187531903	187531903	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr2:187531903C>A	ENST00000261023.3	+	23	2547	c.2273C>A	c.(2272-2274)cCa>cAa	p.P758Q	ITGAV_ENST00000433736.2_Missense_Mutation_p.P712Q|ITGAV_ENST00000374907.3_Missense_Mutation_p.P722Q|AC017101.10_ENST00000453665.1_RNA	NM_002210.3	NP_002201.1	P06756	ITAV_HUMAN	integrin, alpha V	758					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		AAAGTAAGCCCAGTTGTATCT	0.338000													28	64					5.60225e-13	6.74283e-13	1	1	0
CCDC108	255101	broad.mit.edu	37	2	219869128	219869128	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr2:219869128C>G	ENST00000341552.5	-	33	5184	c.5101G>C	c.(5101-5103)Gtg>Ctg	p.V1701L	CCDC108_ENST00000453220.1_Missense_Mutation_p.V1701L|CCDC108_ENST00000441968.1_Missense_Mutation_p.V1701L|AC097468.4_ENST00000441450.1_RNA	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1701						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACCTGCTCCACCAGGCTTTGG	0.557000													40	133					0	0	1	0	0
SLC26A10	65012	broad.mit.edu	37	12	58016619	58016619	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr12:58016619G>T	ENST00000379218.2	+	6	1152	c.841G>T	c.(841-843)Gct>Tct	p.A281S	SLC26A10_ENST00000320442.4_Missense_Mutation_p.A281S			Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	281						integral to membrane	antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)	19	Melanoma(17;0.122)					CAGGATTCTGGCTGACTCGCT	0.562000													24	102					9.86323e-18	1.28734e-17	1	1	0
CDH8	1006	broad.mit.edu	37	16	61687617	61687617	+	Silent	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr16:61687617G>T	ENST00000577390.1	-	12	3249	c.2295C>A	c.(2293-2295)acC>acA	p.T765T	CDH8_ENST00000577730.1_Intron|CDH8_ENST00000299345.6_Intron	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	765					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		AGTCTGATGTGGTGGACTCCA	0.517000													38	45					7.04047e-22	9.56173e-22	1	1	0
CYC1	1537	broad.mit.edu	37	8	145151603	145151603	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr8:145151603C>T	ENST00000318911.4	+	5	801	c.728C>T	c.(727-729)gCc>gTc	p.A243V		NM_001916.3	NP_001907.2	P08574	CY1_HUMAN	cytochrome c-1	243					respiratory electron transport chain|transport	cell junction|integral to membrane|mitochondrial inner membrane|respiratory chain	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|heme binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)	15	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;8.71e-40)|all cancers(56;3e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CAGGCCATTGCCATGGCCCCT	0.577000													39	103					0	0	1	0	0
TOP3B	8940	broad.mit.edu	37	22	22316964	22316964	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr22:22316964C>G	ENST00000398793.2	-	13	1796	c.1362G>C	c.(1360-1362)gaG>gaC	p.E454D	TOP3B_ENST00000413067.2_Missense_Mutation_p.E183D|TOP3B_ENST00000357179.5_Missense_Mutation_p.E454D	NM_003935.3	NP_003926.1	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	454					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(4)|lung(9)|ovary(1)	26	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		AGGGCATGACCTCCGTGAAGC	0.662000													24	15					0	0	1	0	0
GLIPR1	11010	broad.mit.edu	37	12	75875810	75875810	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr12:75875810A>G	ENST00000266659.3	+	2	572	c.371A>G	c.(370-372)tAt>tGt	p.Y124C		NM_006851.2	NP_006842.2	P48060	GLIP1_HUMAN	GLI pathogenesis-related 1	124					cellular lipid metabolic process	extracellular region|integral to membrane				endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	14						ATCCAGGACTATGACTTCAAG	0.443000													38	157					0	0	1	0	0
ELAC1	55520	broad.mit.edu	37	18	48500918	48500918	+	Silent	SNP	C	C	T	rs62092861		TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr18:48500918C>T	ENST00000269466.3	+	2	251	c.144C>T	c.(142-144)agC>agT	p.S48S	RP11-729L2.2_ENST00000590722.2_Silent_p.S48S|ELAC1_ENST00000591429.1_Silent_p.S48S|SMAD4_ENST00000452201.2_5'UTR|RP11-729L2.2_ENST00000588256.1_3'UTR|ELAC1_ENST00000588577.1_Silent_p.S48S	NM_018696.2	NP_061166.1	Q9H777	RNZ1_HUMAN	elaC ribonuclease Z 1	48					tRNA 3'-trailer cleavage	nucleus	endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			kidney(1)|large_intestine(4)|prostate(1)	6		Colorectal(6;0.0269)|all_epithelial(6;0.0729)		Colorectal(21;0.000943)|COAD - Colon adenocarcinoma(17;0.0398)|READ - Rectum adenocarcinoma(32;0.0894)|STAD - Stomach adenocarcinoma(97;0.18)		TTATGAAAAGCCAACTTAAAG	0.468000													9	58					0	0	1	0	0
OSBPL7	114881	broad.mit.edu	37	17	45886269	45886269	+	Nonsense_Mutation	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr17:45886269G>T	ENST00000007414.3	-	21	2449	c.2258C>A	c.(2257-2259)tCg>tAg	p.S753*	OSBPL7_ENST00000392507.3_Nonsense_Mutation_p.S753*	NM_145798.2	NP_665741.1	Q9BZF2	OSBL7_HUMAN	oxysterol binding protein-like 7	753					lipid transport		lipid binding			autonomic_ganglia(1)|endometrium(6)|kidney(2)|large_intestine(5)|liver(2)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32						GGAAGGCAGCGACCGTTTCAG	0.592000													107	75					5.28548e-51	7.64303e-51	1	1	0
FAM166A	401565	broad.mit.edu	37	9	140139180	140139180	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr9:140139180C>T	ENST00000344774.4	-	5	715	c.661G>A	c.(661-663)Ggc>Agc	p.G221S		NM_001001710.1	NP_001001710.1	Q6J272	F166A_HUMAN	family with sequence similarity 166, member A	221										kidney(3)|lung(7)|ovary(2)|prostate(1)|urinary_tract(2)	15						GGAATGAAGCCAGCATAGCCT	0.597000													7	7					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3235842	3235842	+	Silent	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chrX:3235842G>T	ENST00000217939.6	-	6	6034	c.5880C>A	c.(5878-5880)gtC>gtA	p.V1960V		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1960	Ig-like C2-type 4.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GGTAGACAGTGACGTCCTGGT	0.582000													18	50					2.35188e-11	2.74842e-11	1	1	0
COL20A1	57642	broad.mit.edu	37	20	61950473	61950473	+	Silent	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr20:61950473C>A	ENST00000422202.1	+	21	2816	c.2748C>A	c.(2746-2748)ccC>ccA	p.P916P	COL20A1_ENST00000435874.1_Silent_p.P916P|COL20A1_ENST00000326996.6_Silent_p.P909P|COL20A1_ENST00000358894.6_Silent_p.P909P			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	909	TSP N-terminal.				cell adhesion	collagen|extracellular space	structural molecule activity	p.P909P(1)		NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					GCCTACTTCCCGAGACACCCC	0.652000													12	51					1.5842e-08	1.80923e-08	1	1	0
MAGEB1	4112	broad.mit.edu	37	X	30269467	30269467	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chrX:30269467T>C	ENST00000378981.3	+	4	1178	c.857T>C	c.(856-858)cTc>cCc	p.L286P	MAGEB1_ENST00000397548.2_Missense_Mutation_p.L286P|MAGEB1_ENST00000397550.1_Missense_Mutation_p.L286P	NM_002363.4	NP_002354.2	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	286	MAGE.									NS(2)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	32						ATGAAAGTCCTCGAGTTTTTG	0.507000													39	46					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57577918	57577918	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr12:57577918C>T	ENST00000243077.3	+	37	6446	c.5980C>T	c.(5980-5982)Ctc>Ttc	p.L1994F		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	1994					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GGTCGCCCGGCTCAATGGCTC	0.602000													8	59					0	0	1	0	0
CADPS	8618	broad.mit.edu	37	3	62636610	62636610	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr3:62636610C>T	ENST00000383710.4	-	5	1464	c.1115G>A	c.(1114-1116)cGc>cAc	p.R372H	CADPS_ENST00000490353.2_Missense_Mutation_p.R372H|CADPS_ENST00000357948.3_Missense_Mutation_p.R372H|CADPS_ENST00000283269.9_Missense_Mutation_p.R372H	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	372					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		ATTGTGGCTGCGTTTGAGTTT	0.512000													28	105					0	0	1	0	0
PHEX	5251	broad.mit.edu	37	X	22095703	22095703	+	Silent	SNP	G	G	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chrX:22095703G>A	ENST00000379374.4	+	5	1111	c.546G>A	c.(544-546)gaG>gaA	p.E182E	PHEX_ENST00000537599.1_Silent_p.E182E|PHEX_ENST00000535894.1_Silent_p.E85E	NM_000444.4	NP_000435.3	P78562	PHEX_HUMAN	phosphate regulating endopeptidase homolog, X-linked	182					biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(12)|liver(1)|lung(19)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	42						TTTGGTCAGAGAGAAAGTTCA	0.483000													143	36					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125281904	125281904	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr2:125281904G>T	ENST00000431078.1	+	9	1713	c.1349G>T	c.(1348-1350)tGg>tTg	p.W450L		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	450	Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		GATGGCCTGTGGCACTCGGTT	0.532000													23	49					1.50039e-11	1.76362e-11	1	1	0
KRTAP5-4	387267	broad.mit.edu	37	11	1642785	1642785	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr11:1642785C>A	ENST00000399682.1	-	1	583	c.539G>T	c.(538-540)tGc>tTc	p.C180F		NM_001012709.1	NP_001012727.1	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	240	9 X 4 AA repeats of C-C-X-P.					keratin filament				NS(1)|endometrium(9)|kidney(2)|lung(2)|pancreas(1)|prostate(3)|skin(2)	20		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GTAGGGCTTGCAGCAGCTGGA	0.607000													65	191					1.7104e-27	2.35473e-27	1	1	0
EML5	161436	broad.mit.edu	37	14	89163292	89163292	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr14:89163292C>G	ENST00000554922.1	-	15	2491	c.2243G>C	c.(2242-2244)gGt>gCt	p.G748A	EML5_ENST00000380664.5_Missense_Mutation_p.G748A|EML5_ENST00000352093.5_Missense_Mutation_p.G748A	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	748						cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						GGGATCTCTACCAACCTAAAA	0.318000													20	30					0	0	1	0	0
CAPSL	133690	broad.mit.edu	37	5	35910141	35910141	+	Nonsense_Mutation	SNP	G	G	A			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr5:35910141G>A	ENST00000397367.2	-	4	478	c.352C>T	c.(352-354)Caa>Taa	p.Q118*	CAPSL_ENST00000397366.1_Nonsense_Mutation_p.Q118*|CAPSL_ENST00000514524.1_Nonsense_Mutation_p.Q118*	NM_144647.3	NP_653248.3	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	118	EF-hand 3.					cytoplasm	calcium ion binding			central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(10)|skin(1)|urinary_tract(1)	19	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			CTAAAAGCTTGCATGATTACC	0.373000													49	52					0	0	1	0	0
TARS	6897	broad.mit.edu	37	5	33461006	33461006	+	Splice_Site	SNP	G	G	C			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr5:33461006G>C	ENST00000265112.3	+	12	1561		c.e12-1		TARS_ENST00000502553.1_Splice_Site|TARS_ENST00000414361.2_Splice_Site|TARS_ENST00000541634.1_Splice_Site|TARS_ENST00000455217.2_Splice_Site	NM_152295.4	NP_689508.3	P26639	SYTC_HUMAN	threonyl-tRNA synthetase						threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			NS(1)|biliary_tract(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)	29					L-Threonine(DB00156)	TTTCTCTTCAGCCTTATGTTT	0.433000													15	37					0	0	1	0	0
ABCB8	11194	broad.mit.edu	37	7	150733016	150733016	+	Silent	SNP	G	G	C			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr7:150733016G>C	ENST00000358849.4	+	7	1068	c.975G>C	c.(973-975)cgG>cgC	p.R325R	ABCB8_ENST00000498578.1_Silent_p.R325R|ABCB8_ENST00000477719.1_Silent_p.R325R|ABCB8_ENST00000477092.1_Silent_p.R325R|ABCB8_ENST00000356058.4_Silent_p.R362R|ABCB8_ENST00000297504.6_Silent_p.R342R|ABCB8_ENST00000542328.1_Silent_p.R237R	NM_007188.3	NP_009119.2	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 8	342	ABC transmembrane type-1.					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCAATGTGCGGACTGTGCGTG	0.607000													21	45					0	0	1	0	0
TBC1D22A	25771	broad.mit.edu	37	22	47393548	47393548	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr22:47393548C>G	ENST00000337137.4	+	10	1310	c.1144C>G	c.(1144-1146)Caa>Gaa	p.Q382E	TBC1D22A_ENST00000406733.1_Missense_Mutation_p.Q335E|TBC1D22A_ENST00000407381.3_Missense_Mutation_p.Q323E|TBC1D22A_ENST00000355704.3_Missense_Mutation_p.Q304E	NM_014346.2	NP_055161.1	Q8WUA7	TB22A_HUMAN	TBC1 domain family, member 22A	382	Rab-GAP TBC.					intracellular	protein homodimerization activity|Rab GTPase activator activity			breast(1)|endometrium(3)|large_intestine(10)|lung(5)|ovary(2)|prostate(1)	22		all_cancers(38;4.44e-05)|all_epithelial(38;0.000507)|Breast(42;0.0488)|all_lung(38;0.0682)|Ovarian(80;0.0731)|all_neural(38;0.0966)|Glioma(61;0.222)|Lung SC(80;0.236)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0347)|BRCA - Breast invasive adenocarcinoma(115;0.231)		CACCTTTGCCCAACCTGGGAT	0.438000													14	41					0	0	1	0	0
ZNF404	342908	broad.mit.edu	37	19	44378155	44378155	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr19:44378155C>G	ENST00000587539.1	-	3	210	c.211G>C	c.(211-213)Gag>Cag	p.E71Q	ZNF404_ENST00000324394.6_Missense_Mutation_p.E69Q	NM_001033719.2	NP_001028891.2	Q494X3	ZN404_HUMAN	zinc finger protein 404	71	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|skin(1)|stomach(2)|urinary_tract(1)	17		Prostate(69;0.0352)				TTCCATGTCTCCTGATGGTAC	0.328000													21	82					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14555758	14555759	+	RNA	INS	-	-	AGTT	rs10656368	by1000genomes	TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr3:14555758_14555759insAGTT	ENST00000273083.3	-	0	1558							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						CAGTTTCTCTCAGAGAGTGGCA	0.579													2	4	---	---	---	---					
RGS12	6002	broad.mit.edu	37	4	3344676	3344676	+	Frame_Shift_Del	DEL	G	G	-			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr4:3344676delG	ENST00000336727.3	+	3	2798	c.1894delG	c.(1894-1896)ggfs	p.G632fs	RGS12_ENST00000382788.3_Frame_Shift_Del_p.G632fs|RGS12_ENST00000306648.7_Frame_Shift_Del_p.G30fs|RGS12_ENST00000543385.1_Frame_Shift_Del_p.G632fs|RGS12_ENST00000344733.5_Frame_Shift_Del_p.G632fs	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	632						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CTCAAAATTTGGGCGGGGAAC	0.453													67	60	---	---	---	---					
DLX6	1750	broad.mit.edu	37	7	96635420	96635421	+	In_Frame_Ins	INS	-	-	GCC			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr7:96635420_96635421insGCC	ENST00000518156.2	+	1	561_562	c.131_132insGCC	c.(130-132)ccc>cGCCcc	p.43_44insR	DLX6-AS1_ENST00000605417.1_RNA|DLX6-AS1_ENST00000458352.2_RNA|DLX6-AS1_ENST00000452769.2_RNA|DLX6-AS1_ENST00000430027.2_RNA|DLX6-AS1_ENST00000437331.2_RNA|DLX6_ENST00000007660.5_Intron|DLX6-AS1_ENST00000430404.2_RNA|DLX6-AS1_ENST00000437541.1_RNA			P56179	DLX6_HUMAN	distal-less homeobox 6	0					nervous system development|skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(1)|liver(2)|lung(4)|ovary(2)|urinary_tract(1)	12	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					caacagcaacagccgccgccgc	0.698													2	4	---	---	---	---					
LOC101928451	101928451	broad.mit.edu	37	7	128210234	128210235	+	RNA	INS	-	-	TT	rs57917869		TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr7:128210234_128210235insTT	ENST00000605862.1	+	0	189																											agttttagttcttTTTTTTTTT	0.441													4	5	---	---	---	---					
ART5	116969	broad.mit.edu	37	11	3660979	3660980	+	Frame_Shift_Ins	INS	-	-	G	rs74708481		TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr11:3660979_3660980insG	ENST00000397068.3	-	2	1071_1072	c.679_680insC	c.(679-681)tgafs	p.*227fs	ART5_ENST00000359918.4_Frame_Shift_Ins_p.*227fs|ART5_ENST00000397067.3_Intron	NM_053017.3	NP_443750.2	Q96L15	NAR5_HUMAN	ADP-ribosyltransferase 5	227						extracellular region	NAD(P)+-protein-arginine ADP-ribosyltransferase activity			breast(1)|central_nervous_system(1)|large_intestine(2)|lung(6)|ovary(1)	11		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0336)|LUSC - Lung squamous cell carcinoma(625;0.19)		AAAGACTTCATGGGGGGGAATC	0.500													41	125	---	---	---	---					
OR51L1	119682	broad.mit.edu	37	11	5020813	5020813	+	Frame_Shift_Del	DEL	G	G	-			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr11:5020813delG	ENST00000321543.1	+	1	601	c.601delG	c.(601-603)ggfs	p.G201fs		NM_001004755.1	NP_001004755.1	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L, member 1	201					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(19)|skin(2)|stomach(1)	31		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAGTATTTATGGGCTTTGTGT	0.428													16	83	---	---	---	---					
MMP13	4322	broad.mit.edu	37	11	102818723	102818723	+	Frame_Shift_Del	DEL	T	T	-			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr11:102818723delT	ENST00000260302.3	-	8	1136	c.1108delA	c.(1108-1110)tafs	p.I370fs	MMP13_ENST00000340273.4_Frame_Shift_Del_p.I370fs	NM_002427.3	NP_002418.1	P45452	MMP13_HUMAN	matrix metallopeptidase 13 (collagenase 3)	370	Hemopexin-like 2.				collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|skin(1)|stomach(1)	27		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		AGTTCAGATATTTTTTTGGGA	0.388													14	56	---	---	---	---					
USP2	9099	broad.mit.edu	37	11	119227556	119227556	+	Frame_Shift_Del	DEL	A	A	-			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr11:119227556delA	ENST00000260187.2	-	13	2101	c.1807delT	c.(1807-1809)ccfs	p.S603fs	USP2_ENST00000525735.1_Frame_Shift_Del_p.S394fs|USP2_ENST00000455332.2_Frame_Shift_Del_p.S360fs	NM_004205.4	NP_004196.4	O75604	UBP2_HUMAN	ubiquitin specific peptidase 2	603				PSRM -> TSPI (in Ref. 1; AAC28392).	cell cycle|muscle organ development|negative regulation of transcription from RNA polymerase II promoter|positive regulation of mitotic cell cycle|protein deubiquitination|protein stabilization|ubiquitin-dependent protein catabolic process	nucleus|perinuclear region of cytoplasm	cyclin binding|cysteine-type endopeptidase activity|metal ion binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	24		all_hematologic(192;4.65e-05)|Breast(348;0.0101)|all_neural(223;0.0218)|Medulloblastoma(222;0.0425)|Renal(330;0.157)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.000513)|Colorectal(284;0.0116)|Lung(307;0.0853)|LUSC - Lung squamous cell carcinoma(976;0.0889)		TACATTCGGGAGGGCGGGCTG	0.582											OREG0021404	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
MIR381HG	378881	broad.mit.edu	37	14	101514904	101514907	+	RNA	DEL	GTGT	GTGT	-			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr14:101514904_101514907delGTGT	ENST00000553692.1	+	0	28																											CACCTCTGGGgtgtgtgtgtgtgt	0.471													2	4	---	---	---	---					
SNHG14	104472715	broad.mit.edu	37	15	25326493	25326494	+	RNA	DEL	CT	CT	-			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr15:25326493_25326494delCT	ENST00000546682.1	+	0	71				SNORD116-15_ENST00000384445.1_RNA|SNHG14_ENST00000549804.2_RNA	NR_003361.1																						TGAGTGAAAACTCTATACCGTC	0.465													7	223	---	---	---	---					
ORC6	23594	broad.mit.edu	37	16	46729524	46729525	+	Frame_Shift_Ins	INS	-	-	A	rs35441257		TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr16:46729524_46729525insA	ENST00000566860.1	+	4	640_641	c.353_354insA	c.(352-354)gaafs	p.E118fs	ORC6_ENST00000575571.1_3'UTR|ORC6_ENST00000568364.2_Intron|ORC6_ENST00000219097.2_Frame_Shift_Ins_p.E167fs			Q9Y5N6	ORC6_HUMAN	origin recognition complex, subunit 6	167					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA binding|protein binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	8						ACATCCGGTGTAAAAAAAGCTA	0.351													14	55	---	---	---	---					
POLDIP2	26073	broad.mit.edu	37	17	26684390	26684391	+	Frame_Shift_Ins	INS	-	-	C	rs148075904	by1000genomes	TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr17:26684390_26684391insC	ENST00000540200.1	-	2	80_81	c.81_82insG	c.(79-84)aacgctfs	p.NA27fs	POLDIP2_ENST00000003607.4_5'UTR	NM_015584.3	NP_056399.1	Q9Y2S7	PDIP2_HUMAN	polymerase (DNA-directed), delta interacting protein 2	28						mitochondrial nucleoid|nucleus						all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		GCACAGAGCGGCTTTGCCACCG	0.762													3	5	---	---	---	---					
WBP11P1	441818	broad.mit.edu	37	18	30091811	30091812	+	RNA	INS	-	-	AA			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr18:30091811_30091812insAA	ENST00000567636.1	+	0	186_187					NR_003558.1																						GTAAACCATACAAATTGTCAAC	0.431													16	86	---	---	---	---					
KEAP1	9817	broad.mit.edu	37	19	10597393	10597393	+	Frame_Shift_Del	DEL	C	C	-			TCGA-MP-A4TE-01A-22D-A25L-08	TCGA-MP-A4TE-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6FD06171-694B-41C5-8D92-739A884132B2	77083AC4-FD20-4286-8DE0-D578F6B83CE3	g.chr19:10597393delC	ENST00000171111.5	-	6	2357	c.1810delG	c.(1810-1812)tgfs	p.V604fs	KEAP1_ENST00000393623.2_Frame_Shift_Del_p.V604fs	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	604					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GCCACGCCCACCCCACTCCGG	0.552													113	55	---	---	---	---