Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF212	7988	broad.mit.edu	37	7	148951187	148951187	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr7:148951187G>C	ENST00000335870.2	+	5	1297	c.1169G>C	c.(1168-1170)tGc>tCc	p.C390S		NM_012256.3	NP_036388.2	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	390					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|ovary(1)|prostate(1)	9	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			CATCAGCGTTGCCACCTGCAG	0.602000													4	26					0	0	1	0	0
BTN2A3P	54718	broad.mit.edu	37	6	26422353	26422353	+	RNA	SNP	C	C	T	rs141013110		TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr6:26422353C>T	ENST00000466808.2	+	0	7																		p.P3S(2)									GCTCATGGAACCAGCTGCTGC	0.622000													5	110					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197348668	197348668	+	RNA	SNP	C	C	G	rs79940815	by1000genomes	TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr3:197348668C>G	ENST00000418868.1	-	0	591					NR_003266.2																						ACTTGAGGCTCTGTCCACCAA	0.488000													6	122					0	0	1	0	0
SEPT1	1731	broad.mit.edu	37	16	30391351	30391351	+	Silent	SNP	G	G	T			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr16:30391351G>T	ENST00000321367.3	-	8	748	c.703C>A	c.(703-705)Cgg>Agg	p.R235R	SEPT1_ENST00000605106.1_Silent_p.R193R|SEPT1_ENST00000571393.1_Silent_p.R188R	NM_052838.4	NP_443070.5	Q8WYJ6	SEPT1_HUMAN	septin 1	188					cell cycle|cell division	microtubule organizing center|septin complex	GTP binding|protein binding			breast(2)|endometrium(1)|large_intestine(3)|lung(15)|ovary(1)|skin(1)|urinary_tract(1)	24			Colorectal(24;0.193)			AACTGATCCCGGATCTCAGGG	0.483000													8	60					0.000157383	0.000171911	1	1	0
VWC2	375567	broad.mit.edu	37	7	49951718	49951718	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr7:49951718G>C	ENST00000340652.3	+	4	1471	c.915G>C	c.(913-915)gaG>gaC	p.E305D	ZPBP_ENST00000491129.1_Intron	NM_198570.3	NP_940972.2	Q2TAL6	VWC2_HUMAN	von Willebrand factor C domain containing 2	305					negative regulation of BMP signaling pathway|positive regulation of neuron differentiation	basement membrane|extracellular space				cervix(1)|endometrium(2)|large_intestine(1)|lung(3)|prostate(1)	8						GTACTTATGAGGAAGGCACAT	0.498000													6	80					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20337679	20337679	+	Silent	SNP	C	C	T			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr16:20337679C>T	ENST00000302555.5	-	2	224	c.75G>A	c.(73-75)caG>caA	p.Q25Q	GP2_ENST00000381360.5_Silent_p.Q25Q|GP2_ENST00000381362.4_Silent_p.Q25Q|GP2_ENST00000341642.5_Silent_p.Q25Q			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	25						anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CTGCAGATGCCTGGGTCAGAA	0.537000													8	53					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55259515	55259515	+	Missense_Mutation	SNP	T	T	G	rs121434568		TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr7:55259515T>G	ENST00000275493.2	+	21	2750	c.2573T>G	c.(2572-2574)cTg>cGg	p.L858R	EGFR_ENST00000442591.1_Intron|EGFR_ENST00000454757.2_Missense_Mutation_p.L805R|EGFR_ENST00000455089.1_Missense_Mutation_p.L813R	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	858	Protein kinase.		L -> M (found in a lung cancer sample).|L -> R (found in a lung cancer sample; somatic mutation; constitutively activated enzyme with strongly increased kinase activity).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.L858R(1489)|p.L858Q(1)|p.L858K(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GATTTTGGGCTGGCCAAACTG	0.537000	L858R(NCIH1975_LUNG)	8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			58	147					0	0	1	0	0
TFAP2B	7021	broad.mit.edu	37	6	50805757	50805757	+	Silent	SNP	G	G	A			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr6:50805757G>A	ENST00000263046.4	+	6	1084	c.918G>A	c.(916-918)gcG>gcA	p.A306A	TFAP2B_ENST00000393655.3_Silent_p.A297A			Q92481	AP2B_HUMAN	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	297					nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)	40	Lung NSC(77;0.156)					ATTTACCCGCGGGCAGGCGCA	0.468000													17	111					0	0	1	0	0
C1orf52	148423	broad.mit.edu	37	1	85718325	85718325	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr1:85718325T>C	ENST00000471115.1	-	3	544	c.536A>G	c.(535-537)aAg>aGg	p.K179R	C1orf52_ENST00000294661.4_5'UTR	NM_198077.3	NP_932343.1	Q8N6N3	CA052_HUMAN	chromosome 1 open reading frame 52	179										endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)	10				all cancers(265;0.0105)|Epithelial(280;0.0293)		CTTTTTCTTCTTTGCTGGTTC	0.323000													4	32					0	0	1	0	0
MARK1	4139	broad.mit.edu	37	1	220805632	220805632	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr1:220805632C>T	ENST00000402574.1	+	11	1696	c.694C>T	c.(694-696)Ctt>Ttt	p.L232F	MARK1_ENST00000366917.4_Missense_Mutation_p.L367F|MARK1_ENST00000366918.4_Missense_Mutation_p.L345F	NM_018650.3	NP_061120.3	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	367	Protein kinase.				intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(12)|lung(22)|ovary(4)|pancreas(1)|skin(3)|stomach(3)|urinary_tract(1)	63				GBM - Glioblastoma multiforme(131;0.0407)		TACTTATATTCTTCTAGGTAG	0.303000													8	145					0	0	1	0	0
NBAS	51594	broad.mit.edu	37	2	15608557	15608557	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr2:15608557C>T	ENST00000281513.5	-	17	1851	c.1826G>A	c.(1825-1827)gGc>gAc	p.G609D	NBAS_ENST00000441750.1_Missense_Mutation_p.G609D	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	609										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						CAGGTCTGTGCCTTTTAATCC	0.408000													16	136					0	0	1	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140772467	140772467	+	Silent	SNP	A	A	G			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr5:140772467A>G	ENST00000398604.2	+	1	87	c.87A>G	c.(85-87)ggA>ggG	p.G29G	PCDHGA6_ENST00000517434.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGGGAGGGGACAGATTCGCT	0.617000													3	38					0	0	1	0	0
HTATSF1	27336	broad.mit.edu	37	X	135579988	135579988	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chrX:135579988C>T	ENST00000535601.1	+	2	567	c.145C>T	c.(145-147)Ccc>Tcc	p.P49S	HTATSF1_ENST00000218364.4_Missense_Mutation_p.P49S	NM_001163280.1	NP_001156752.1	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	49					regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(3)|prostate(1)	30	Acute lymphoblastic leukemia(192;0.000127)					GACGGACACTCCCTACGAGTG	0.642000													6	97					0	0	1	0	0
OR4L1	122742	broad.mit.edu	37	14	20528290	20528290	+	Silent	SNP	G	G	T	rs147167330		TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr14:20528290G>T	ENST00000315683.1	+	1	87	c.87G>T	c.(85-87)gtG>gtT	p.V29V		NM_001004717.1	NP_001004717.1	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L, member 1	29					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V29V(2)		central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(16)|ovary(2)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		TCTTCTTTGTGACATTTTCCC	0.388000													9	204					7.48243e-07	9.00428e-07	1	1	0
SERPINI1	5274	broad.mit.edu	37	3	167512516	167512516	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr3:167512516T>A	ENST00000295777.5	+	5	1216	c.785T>A	c.(784-786)gTt>gAt	p.V262D	SERPINI1_ENST00000446050.2_Missense_Mutation_p.V262D	NM_005025.4	NP_005016.1	Q99574	NEUS_HUMAN	serpin peptidase inhibitor, clade I (neuroserpin), member 1	262					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(7)|skin(2)	20						AGACAGGAAGTTCCTCTTGCT	0.448000													6	55					0	0	1	0	0
SYNPO	11346	broad.mit.edu	37	5	150029662	150029662	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr5:150029662C>T	ENST00000394243.1	+	3	2931	c.2557C>T	c.(2557-2559)Cca>Tca	p.P853S	SYNPO_ENST00000522122.1_Missense_Mutation_p.P853S|SYNPO_ENST00000519664.1_Missense_Mutation_p.P609S|SYNPO_ENST00000307662.4_Missense_Mutation_p.P609S	NM_001166208.1	NP_001159680.1	Q8N3V7	SYNPO_HUMAN	synaptopodin	853	Pro-rich.				positive regulation of actin filament bundle assembly|regulation of stress fiber assembly	actin cytoskeleton|cytoplasm|dendritic spine|perikaryon|postsynaptic density|postsynaptic membrane|tight junction	actin binding|protein binding			NS(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(4)|prostate(1)|urinary_tract(2)	18		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGCTCTCCCTCCATCTCCTGC	0.687000													7	116					0	0	1	0	0
CIAO1	9391	broad.mit.edu	37	2	96933137	96933137	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr2:96933137G>T	ENST00000488633.1	+	2	437	c.218G>T	c.(217-219)gGt>gTt	p.G73V	CIAO1_ENST00000469320.1_3'UTR	NM_004804.2	NP_004795.1	O76071	CIAO1_HUMAN	cytosolic iron-sulfur protein assembly 1	73					chromosome segregation|iron-sulfur cluster assembly|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter	MMXD complex	protein binding			endometrium(1)|lung(2)|stomach(1)|upper_aerodigestive_tract(1)	5						TCCCCCTGCGGTAATTACCTG	0.557000													27	136					3.73808e-20	4.65621e-20	1	1	0
NLRP5	126206	broad.mit.edu	37	19	56569755	56569755	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr19:56569755C>T	ENST00000390649.3	+	14	3449	c.3449C>T	c.(3448-3450)aCg>aTg	p.T1150M		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	1150						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GCCTGTCCCACGTCTAACTTA	0.483000													3	29					0	0	1	0	0
NUMA1	4926	broad.mit.edu	37	11	71725388	71725388	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr11:71725388T>A	ENST00000393695.3	-	15	3492	c.3161A>T	c.(3160-3162)cAt>cTt	p.H1054L	NUMA1_ENST00000358965.6_Missense_Mutation_p.H1054L|NUMA1_ENST00000351960.6_Intron|RP11-849H4.4_ENST00000502284.1_RNA	NM_006185.2	NP_006176.2	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1054					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(12)|lung(20)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	65						CGTCAGGGCATGAGCCAGTGC	0.602000			T	RARA	APL								6	123					0	0	1	0	0
GOLGA6L17P	642402	broad.mit.edu	37	15	85053124	85053124	+	RNA	SNP	G	G	T			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr15:85053124G>T	ENST00000414190.2	-	0	328					NR_003246.2																						TAAATGTTTTGTTTTTTTTTT	0.353000													3	10					0.184627	0.187265	1	1	0
HSF2	3298	broad.mit.edu	37	6	122753222	122753222	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr6:122753222A>G	ENST00000452194.1	+	12	1601	c.1414A>G	c.(1414-1416)Agc>Ggc	p.S472G	HSF2_ENST00000368455.4_Missense_Mutation_p.S490G	NM_001135564.1	NP_001129036.1	Q03933	HSF2_HUMAN	heat shock transcription factor 2	490					response to stress|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			large_intestine(4)|lung(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				OV - Ovarian serous cystadenocarcinoma(136;0.00371)|all cancers(137;0.0299)|GBM - Glioblastoma multiforme(226;0.0586)		TCTGGATAGCAGCCTAGACCC	0.448000													23	101					0	0	1	0	0
CBWD6	644019	broad.mit.edu	37	9	69247529	69247529	+	Silent	SNP	G	G	A			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr9:69247529G>A	ENST00000377457.5	-	5	588	c.483C>T	c.(481-483)taC>taT	p.Y161Y	CBWD6_ENST00000377449.1_Silent_p.Y125Y|CBWD6_ENST00000382399.4_Intron	NM_001085457.1	NP_001078926.1	Q4V339	CBWD6_HUMAN	COBW domain containing 6	161							ATP binding	p.Y161Y(1)		lung(4)	4						TACCATCAAGGTAAATATCAC	0.299000													3	29					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7576853	7576853	+	Splice_Site	SNP	C	C	T	rs11575996		TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr17:7576853C>T	ENST00000420246.2	-	9	1125	c.993_splice	c.e9+1	p.Q331_splice	TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_Splice_Site_p.Q331_splice|TP53_ENST00000445888.2_Splice_Site_p.Q331_splice|TP53_ENST00000269305.4_Splice_Site_p.Q331_splice|TP53_ENST00000359597.4_Splice_Site_p.Q331_splice	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	331	Interaction with CARM1.|Interaction with HIPK1 (By similarity).|Interaction with HIPK2.|Oligomerization.		Q -> H (in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.Q331H(7)|p.Q331P(2)|p.Q331fs*6(1)|p.I332fs*49(1)|p.?(1)|p.Q331Q(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GACTTAGTACCTGAAGGGTGA	0.453000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			12	72					0	0	1	0	0
JADE1	79960	broad.mit.edu	37	4	129776952	129776952	+	Splice_Site	SNP	G	G	A			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr4:129776952G>A	ENST00000226319.6	+	7	1144	c.864_splice	c.e7+1	p.E288_splice	PHF17_ENST00000452328.2_Splice_Site_p.E276_splice|PHF17_ENST00000512960.1_Splice_Site_p.E288_splice|PHF17_ENST00000511647.1_Splice_Site_p.E288_splice|PHF17_ENST00000413543.2_Splice_Site_p.E288_splice	NM_199320.2	NP_955352.1	Q6IE81	JADE1_HUMAN		288					apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						GGATCCCTGAGGTACGTGTGG	0.498000													3	34					0	0	1	0	0
GDF3	9573	broad.mit.edu	37	12	7842942	7842942	+	Silent	SNP	A	A	G			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr12:7842942A>G	ENST00000329913.3	-	2	674	c.627T>C	c.(625-627)gaT>gaC	p.D209D		NM_020634.1	NP_065685.1	Q9NR23	GDF3_HUMAN	growth differentiation factor 3	209					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	28						CTGAGTCTCTATCTTCTTTGA	0.483000													10	81					0	0	1	0	0
GPR119	139760	broad.mit.edu	37	X	129519184	129519184	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chrX:129519184G>T	ENST00000276218.2	-	1	327	c.238C>A	c.(238-240)Ctg>Atg	p.L80M		NM_178471.2	NP_848566.1	Q8TDV5	GP119_HUMAN	G protein-coupled receptor 119	80						integral to membrane|plasma membrane	lipid binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(3)|prostate(1)	11						GCCATCCGCAGGCTGCACAGG	0.582000													20	196					1.2644e-06	1.49621e-06	1	1	0
TUBBP5	643224	broad.mit.edu	37	9	141070125	141070125	+	RNA	SNP	C	C	T	rs10867114	by1000genomes	TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr9:141070125C>T	ENST00000503395.1	+	0	1205																											CGCTCGGGGCCCTTCGGGCAG	0.672000													4	76					0	0	1	0	0
MDM2	4193	broad.mit.edu	37	12	69230479	69230479	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr12:69230479G>T	ENST00000462284.1	+	10	1170	c.868G>T	c.(868-870)Ggg>Tgg	p.G290W	MDM2_ENST00000545204.1_Intron|MDM2_ENST00000544561.1_Intron|MDM2_ENST00000258148.7_Missense_Mutation_p.G235W|MDM2_ENST00000540827.1_Missense_Mutation_p.G89W|MDM2_ENST00000393412.3_Intron|MDM2_ENST00000360430.2_Missense_Mutation_p.G89W|MDM2_ENST00000356290.4_Missense_Mutation_p.G114W|MDM2_ENST00000350057.5_Missense_Mutation_p.G259W|MDM2_ENST00000393413.3_Intron|MDM2_ENST00000299252.4_Missense_Mutation_p.G114W|MDM2_ENST00000348801.2_Intron|MDM2_ENST00000258149.5_Missense_Mutation_p.G229W|MDM2_ENST00000478070.1_Intron|MDM2_ENST00000428863.2_Intron|MDM2_ENST00000393410.1_Intron|MDM2_ENST00000517852.1_Intron	NM_002392.4	NP_002383.2	Q00987	MDM2_HUMAN	MDM2 oncogene, E3 ubiquitin protein ligase	284	ARF-binding.|Asp/Glu-rich (acidic).|Interaction with MTBP (By similarity).|Necessary for interaction with USP2.|Region II.				cellular response to hypoxia|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|establishment of protein localization|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein complex assembly|protein destabilization|protein localization to nucleus|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to antibiotic|synaptic transmission	cytosol|endocytic vesicle membrane|insoluble fraction|nucleolus|nucleoplasm|plasma membrane|protein complex	enzyme binding|identical protein binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(2)|lung(8)|prostate(1)|urinary_tract(1)	19	all_cancers(1;8.46e-121)|all_epithelial(5;3.21e-36)|Lung NSC(4;2.16e-33)|all_lung(4;3.03e-31)|Glioma(1;1.9e-09)|Breast(13;1.59e-06)|all_neural(1;1.03e-05)|Melanoma(1;0.0171)|Renal(347;0.0684)		all cancers(2;8.67e-65)|GBM - Glioblastoma multiforme(2;8.89e-62)|BRCA - Breast invasive adenocarcinoma(5;2.43e-08)|Lung(24;1.5e-05)|LUAD - Lung adenocarcinoma(15;8.5e-05)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			GTATCAGGCAGGGGAGAGTGA	0.328000			A		"""sarcoma, glioma, colorectal, other"""								7	146					1.12685e-05	1.2501e-05	1	1	0
EML5	161436	broad.mit.edu	37	14	89128042	89128042	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr14:89128042C>A	ENST00000554922.1	-	25	3879	c.3631G>T	c.(3631-3633)Ggg>Tgg	p.G1211W	EML5_ENST00000352093.5_Missense_Mutation_p.G1173W|EML5_ENST00000380664.5_Missense_Mutation_p.G1211W	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	1211						cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						AAATCGTCCCCGGTAGCTAGA	0.363000													4	46					1	1	1	1	0
SLC12A7	10723	broad.mit.edu	37	5	1057693	1057693	+	Silent	SNP	C	C	T			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr5:1057693C>T	ENST00000264930.5	-	22	2962	c.2919G>A	c.(2917-2919)acG>acA	p.T973T		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	973					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	CCTTGTCTGGCGTAGGCGGCG	0.627000													13	198					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196729175	196729175	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr2:196729175G>C	ENST00000312428.6	-	41	7304	c.7204C>G	c.(7204-7206)Caa>Gaa	p.Q2402E		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2402	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TCTTTAATTTGAGTATCTGTA	0.383000													4	69					0	0	1	0	0
IL3RA	3563	broad.mit.edu	37	X	1475147	1475147	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chrX:1475147G>T	ENST00000331035.4	+	7	999	c.650G>T	c.(649-651)tGt>tTt	p.C217F	IL3RA_ENST00000381469.2_Missense_Mutation_p.C139F	NM_001267713.1|NM_002183.3	NP_001254642.1|NP_002174.1	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha (low affinity)	217						integral to membrane|plasma membrane	interleukin-3 receptor activity			lung(1)|skin(2)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	ACTGCAAAGTGTAATAAGACA	0.358000													7	122					1.58986e-06	1.82065e-06	1	1	0
PCNT	5116	broad.mit.edu	37	21	47851912	47851912	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr21:47851912C>T	ENST00000359568.5	+	38	8641	c.8534C>T	c.(8533-8535)tCg>tTg	p.S2845L	PCNT_ENST00000480896.1_Intron	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	2845					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					ACACTGAAGTCGACGGTGGAA	0.562000													6	66					0	0	1	0	0
PISD	23761	broad.mit.edu	37	22	32015685	32015685	+	Silent	SNP	C	C	A			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr22:32015685C>A	ENST00000382151.2	-	8	1460	c.1041G>T	c.(1039-1041)gtG>gtT	p.V347V	PISD_ENST00000266095.5_Silent_p.V347V|PISD_ENST00000397500.1_3'UTR|PISD_ENST00000336566.4_Silent_p.V380V|PISD_ENST00000439502.2_Silent_p.V381V			Q9UG56	PISD_HUMAN	phosphatidylserine decarboxylase	381					phospholipid biosynthetic process	mitochondrion	phosphatidylserine decarboxylase activity			central_nervous_system(3)|endometrium(2)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)	12					Phosphatidylserine(DB00144)	CGAAGATGAGCACGATGGTGG	0.562000													5	61					0.000602214	0.000647837	1	1	0
AFF1	4299	broad.mit.edu	37	4	87968671	87968671	+	Silent	SNP	C	C	T			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr4:87968671C>T	ENST00000307808.6	+	3	1383	c.963C>T	c.(961-963)acC>acT	p.T321T	AFF1_ENST00000395146.4_Silent_p.T328T|AFF1_ENST00000544085.1_Intron	NM_005935.2	NP_005926.1	P51825	AFF1_HUMAN	AF4/FMR2 family, member 1	321						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(2)	3		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		GACAGCAGACCTTTGAAAAAA	0.507000													13	151					0	0	1	0	0
TBX20	57057	broad.mit.edu	37	7	35288308	35288308	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr7:35288308C>T	ENST00000408931.3	-	3	1052	c.526G>A	c.(526-528)Gac>Aac	p.D176N		NM_001077653.2|NM_001166220.1	NP_001071121.1|NP_001159692.1	Q9UMR3	TBX20_HUMAN	T-box 20	176						nucleus	DNA binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(9)|prostate(1)|skin(1)|stomach(1)	18						AACGGCGGGTCGGCCTTGCCA	0.532000													4	71					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858060	9858060	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr16:9858060C>G	ENST00000396573.2	-	14	3650	c.3341G>C	c.(3340-3342)aGa>aCa	p.R1114T	GRIN2A_ENST00000330684.3_Missense_Mutation_p.R1114T|GRIN2A_ENST00000396575.2_Missense_Mutation_p.R1114T|GRIN2A_ENST00000404927.2_Missense_Mutation_p.R1114T|GRIN2A_ENST00000535259.1_Missense_Mutation_p.R957T|GRIN2A_ENST00000562109.1_Missense_Mutation_p.R1114T	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1114					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GATCTTGTCTCTAGGGGAGCT	0.483000													12	219					0	0	1	0	0
CCDC114	93233	broad.mit.edu	37	19	48807229	48807229	+	Silent	SNP	C	C	A			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr19:48807229C>A	ENST00000315396.7	-	7	1405	c.723G>T	c.(721-723)ctG>ctT	p.L241L		NM_144577.3	NP_653178.3	Q96M63	CC114_HUMAN	coiled-coil domain containing 114	241										cervix(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)	24		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		CACGCTTCTCCAGGACATCGG	0.642000													14	109					1.3612e-06	1.58435e-06	1	1	0
FAM96B	51647	broad.mit.edu	37	16	66967955	66967955	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr16:66967955T>A	ENST00000422424.2	-	2	192	c.157A>T	c.(157-159)Atc>Ttc	p.I53F		NM_016062.3	NP_057146.1	Q9Y3D0	MIP18_HUMAN	family with sequence similarity 96, member B	53					chromosome segregation	cytoplasm|MMXD complex|nucleus	protein binding			kidney(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0862)|Epithelial(162;0.198)		GGGTCATTGATGGAGCGAATC	0.577000													4	26					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135427689	135427689	+	Nonsense_Mutation	SNP	C	C	A	rs142010518		TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chrX:135427689C>A	ENST00000394143.1	+	6	2115	c.1824C>A	c.(1822-1824)taC>taA	p.Y608*	GPR112_ENST00000370652.1_Nonsense_Mutation_p.Y608*|GPR112_ENST00000287534.4_Nonsense_Mutation_p.Y545*|GPR112_ENST00000412101.1_Nonsense_Mutation_p.Y403*|GPR112_ENST00000394141.1_Nonsense_Mutation_p.Y403*	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	608					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					GACGAGTTTACACCCAGAATA	0.468000													6	75					1.06961e-07	1.30935e-07	1	1	0
VIPAS39	63894	broad.mit.edu	37	14	77917601	77917601	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr14:77917601C>T	ENST00000553888.1	-	4	782	c.272G>A	c.(271-273)cGa>cAa	p.R91Q	VIPAS39_ENST00000557658.1_Missense_Mutation_p.R91Q|VIPAS39_ENST00000556412.1_Missense_Mutation_p.R117Q|VIPAS39_ENST00000448935.2_Intron|VIPAS39_ENST00000343765.2_Missense_Mutation_p.R91Q|VIPAS39_ENST00000327028.4_Missense_Mutation_p.R91Q	NM_001193314.1|NM_001193317.1|NM_022067.3	NP_001180243.1|NP_001180246.1|NP_071350.2			VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog																		GAAGCTGTTTCGGCTCTTTAG	0.473000													13	195					0	0	1	0	0
ZNF221	7638	broad.mit.edu	37	19	44470451	44470451	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr19:44470451G>C	ENST00000251269.5	+	6	1125	c.797G>C	c.(796-798)aGa>aCa	p.R266T	ZNF221_ENST00000587682.1_Missense_Mutation_p.R266T|ZNF221_ENST00000592350.1_Missense_Mutation_p.R266T	NM_013359.2	NP_037491.2	Q9UK13	ZN221_HUMAN	zinc finger protein 221	266					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(11)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	30		Prostate(69;0.0352)				TTCCATAGTAGATCAGCACTT	0.403000													9	226					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90161902	90161902	+	RNA	SNP	A	A	G	rs6500471	by1000genomes	TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr16:90161902A>G	ENST00000567960.1	+	0	638				TUBB8P7_ENST00000564451.1_RNA														p.K213R(8)									ATATGTTCCAAGACCCTAAAA	0.537000													4	33					0	0	1	0	0
RGPD8	727851	broad.mit.edu	37	2	113127775	113127775	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr2:113127775G>C	ENST00000302558.3	-	23	5469	c.5278C>G	c.(5278-5280)Cct>Gct	p.P1760A	RGPD8_ENST00000409750.1_Missense_Mutation_p.P1620A	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8									p.P1760A(12)		endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						GAACGGGAAGGATTTTCTTCC	0.308000													4	58					0	0	1	0	0
CTD-2090I13.1	0	broad.mit.edu	37	1	227618420	227618420	+	RNA	SNP	G	G	C	rs6426453	by1000genomes	TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr1:227618420G>C	ENST00000445817.1	+	0	1655																											GGATGAGGTGGAACGTGTGAT	0.483000													3	38					0	0	1	0	0
RAET1K	646024	broad.mit.edu	37	6	150322211	150322211	+	RNA	SNP	C	C	T	rs9397541	by1000genomes	TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr6:150322211C>T	ENST00000533735.1	-	0	665					NR_024045.1																						GATCCTCTGCCGTGTCCGTGG	0.498000													5	70					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114275390	114275390	+	Silent	SNP	G	G	A			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr4:114275390G>A	ENST00000357077.4	+	38	5669	c.5616G>A	c.(5614-5616)tcG>tcA	p.S1872S	ANK2_ENST00000510275.2_Intron|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000264366.6_Silent_p.S1839S|ANK2_ENST00000509550.1_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	1839	Repeat-rich region.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CGTCATCATCGAGTAAAACTG	0.458000													21	190					0	0	1	0	0
SLC25A24	29957	broad.mit.edu	37	1	108681704	108681704	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr1:108681704C>A	ENST00000565488.1	-	9	1444	c.1225G>T	c.(1225-1227)Gtg>Ttg	p.V409L	SLC25A24_ENST00000370041.4_Missense_Mutation_p.V390L	NM_013386.4	NP_037518.3	Q6NUK1	SCMC1_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24	409					transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	16		all_epithelial(167;3.72e-05)|all_lung(203;0.000567)|Lung NSC(277;0.0011)|Melanoma(281;0.211)		Colorectal(144;0.0345)|Lung(183;0.0971)|COAD - Colon adenocarcinoma(174;0.127)|Epithelial(280;0.134)		CGAGTTCTCACCAAAGCCAAT	0.473000													9	62					1.12685e-05	1.2501e-05	1	1	0
DLX5	1749	broad.mit.edu	37	7	96651595	96651595	+	Nonsense_Mutation	SNP	G	G	A			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr7:96651595G>A	ENST00000222598.4	-	2	915	c.442C>T	c.(442-444)Cag>Tag	p.Q148*	DLX5_ENST00000493764.1_5'UTR|DLX5_ENST00000486603.2_Nonsense_Mutation_p.Q148*	NM_005221.5	NP_005212.1	P56178	DLX5_HUMAN	distal-less homeobox 5	148					cell proliferation|endochondral ossification|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)	20	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					GCGGCCAGCTGAAAGCTGGAA	0.498000													9	129					0	0	1	0	0
TFE3	7030	broad.mit.edu	37	X	48896748	48896748	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chrX:48896748C>A	ENST00000315869.7	-	3	677	c.418G>T	c.(418-420)Gct>Tct	p.A140S	TFE3_ENST00000493583.1_5'UTR	NM_006521.4	NP_006512.2	P19532	TFE3_HUMAN	transcription factor binding to IGHM enhancer 3	140					humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		NONO/TFE3(2)|PRCC/TFE3(25)|SFPQ/TFE3(6)|CLTC/TFE3(2)|ASPSCR1/TFE3(167)	central_nervous_system(1)	1						GGGAAGGGAGCCGCGGCGGCC	0.667000			T	"""SFPQ, ASPSCR1, PRCC, NONO, CLTC"""	"""papillary renal, alveolar soft part sarcoma, renal"""								4	16					0.00909568	0.00935932	1	1	0
ARFGEF2	10564	broad.mit.edu	37	20	47587681	47587681	+	Silent	SNP	G	G	A			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr20:47587681G>A	ENST00000371917.4	+	10	1215	c.1215G>A	c.(1213-1215)gtG>gtA	p.V405V		NM_006420.2	NP_006411.2	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	405					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(7)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	63			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			GTTCCAAGGTGGTTTCCCTGC	0.448000													9	68					0	0	1	0	0
RARA	5914	broad.mit.edu	37	17	38510648	38510648	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr17:38510648G>T	ENST00000254066.5	+	7	1357	c.902G>T	c.(901-903)gGc>gTc	p.G301V	RARA_ENST00000394086.3_Missense_Mutation_p.G317V|RARA_ENST00000425707.3_Missense_Mutation_p.G204V|RARA_ENST00000394081.3_Missense_Mutation_p.G296V|RARA_ENST00000394089.2_Missense_Mutation_p.G301V|RARA_ENST00000420042.1_3'UTR	NM_000964.3	NP_000955.1	P10276	RARA_HUMAN	retinoic acid receptor, alpha	301	Ligand-binding.				apoptotic cell clearance|cellular response to estrogen stimulus|cellular response to retinoic acid|estrogen receptor signaling pathway|negative regulation of granulocyte differentiation|negative regulation of interferon-gamma production|negative regulation of tumor necrosis factor production|positive regulation of binding|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	cytoplasm|nucleoplasm	chromatin DNA binding|enzyme binding|protein domain specific binding|protein heterodimerization activity|receptor binding|retinoic acid binding|retinoic acid receptor activity|retinoic acid-responsive element binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			breast(1)|kidney(4)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|urinary_tract(2)	16		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00143)		Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Isotretinoin(DB00982)|Tamibarotene(DB04942)|Tazarotene(DB00799)	CACAACGCTGGCTTCGGCCCC	0.652000			T	"""PML, ZNF145, TIF1, NUMA1, NPM1"""	APL								7	68					0.00198382	0.00210226	1	1	0
IGHV1-3	28473	broad.mit.edu	37	14	106471356	106471356	+	RNA	SNP	G	G	C			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr14:106471356G>C	ENST00000390595.2	-	0	282																											TGGAACTCCTGTGAATATTTT	0.537000													7	192					0	0	1	0	0
ZNF532	55205	broad.mit.edu	37	18	56585912	56585912	+	Silent	SNP	G	G	T			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr18:56585912G>T	ENST00000336078.4	+	4	1169	c.393G>T	c.(391-393)ccG>ccT	p.P131P	ZNF532_ENST00000589288.1_Silent_p.P131P|ZNF532_ENST00000591808.1_Silent_p.P131P|ZNF532_ENST00000591230.1_Silent_p.P131P|ZNF532_ENST00000591083.1_Silent_p.P131P	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						AGTTTAGCCCGATCTCCAGTG	0.498000													7	88					0.00448238	0.00468013	1	1	0
RP11-400N13.1	0	broad.mit.edu	37	1	222435118	222435119	+	RNA	INS	-	-	T			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr1:222435118_222435119insT	ENST00000416510.1	-	0	167																											GCAATAATTTCTTTTTTTTTTA	0.302													2	4	---	---	---	---					
CASP8AP2	9994	broad.mit.edu	37	6	90556398	90556398	+	RNA	DEL	T	T	-			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr6:90556398delT	ENST00000551025.1	+	0	1492							Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2						cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			NS(1)|endometrium(7)|kidney(6)|large_intestine(12)|lung(21)|ovary(2)|urinary_tract(2)	51		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		TCTAAtttccttttttttttt	0.418													4	6	---	---	---	---					
AKAP2	11217	broad.mit.edu	37	9	112811016	112811033	+	In_Frame_Del	DEL	CCCCCGGAGTCTCCTGGA	CCCCCGGAGTCTCCTGGA	-	rs72207945		TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr9:112811016_112811033delCCCCCGGAGTCTCCTGGA	ENST00000374525.1	+	1	41_58	c.37_54delCCCCCGGAGTCTCCTGGA	c.(37-54)del	p.PPESPG19del	AKAP2_ENST00000555236.1_Intron|AKAP2_ENST00000510514.5_Intron|PALM2-AKAP2_ENST00000302798.7_Intron|AKAP2_ENST00000434623.2_In_Frame_Del_p.PPESPG19del|PALM2-AKAP2_ENST00000374530.3_Intron	NM_001004065.4	NP_001004065.2			A kinase (PRKA) anchor protein 2											breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	33						CGCTCGCCTTCCCCCGGAGTCTCCTGGACCCCCGGAGT	0.789													2	4	---	---	---	---					
LTB4R	1241	broad.mit.edu	37	14	24784977	24785003	+	In_Frame_Del	DEL	GTGGAGTATCCTGAAAAGGATGCAGAA	GTGGAGTATCCTGAAAAGGATGCAGAA	-			TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr14:24784977_24785003delGTGGAGTATCCTGAAAAGGATGCAGAA	ENST00000396789.4	+	2	1845_1871	c.120_146delGTGGAGTATCCTGAAAAGGATGCAGAA	c.(118-147)gtg>gt	p.VWSILKRMQK40del	LTB4R_ENST00000396782.2_In_Frame_Del_p.VWSILKRMQK40del|LTB4R_ENST00000345363.3_In_Frame_Del_p.VWSILKRMQK40del	NM_181657.3	NP_858043.1	Q15722	LT4R1_HUMAN	leukotriene B4 receptor	40					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular component movement|immune response|inflammatory response|muscle contraction	integral to plasma membrane	nucleotide binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|stomach(1)	8				GBM - Glioblastoma multiforme(265;0.018)		GCTTTGTGGTGTGGAGTATCCTGAAAAGGATGCAGAAGCGCTCTGTC	0.586													11	204	---	---	---	---					
LA16c-306E5.3	0	broad.mit.edu	37	16	3546140	3546141	+	RNA	INS	-	-	A	rs74546027		TCGA-MP-A4T9-01A-11D-A24P-08	TCGA-MP-A4T9-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b0ebb2a-a75d-4b90-8e19-e2650becbef8	5a755819-743c-4b5f-96b4-877aecaca981	g.chr16:3546140_3546141insA	ENST00000574423.2	+	0	111																											gactccgtctcaaaaaaaaaaa	0.559													3	6	---	---	---	---