Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LOX	4015	broad.mit.edu	37	5	121405748	121405748	+	Splice_Site	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr5:121405748G>T	ENST00000231004.4	-	6	1546	c.1247_splice	c.e6+1	p.P416_splice	SRFBP1_ENST00000504881.1_Intron|LOX_ENST00000513319.1_5'UTR	NM_001178102.1|NM_002317.5	NP_001171573.1|NP_002308.2	P28300	LYOX_HUMAN	lysyl oxidase	416	Lysyl-oxidase like.				protein modification process	extracellular space	copper ion binding|protein-lysine 6-oxidase activity			endometrium(1)|lung(6)|prostate(1)	8		all_cancers(142;0.0124)|Prostate(80;0.0322)|Ovarian(225;0.0814)|Breast(839;0.143)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;2.14e-11)|OV - Ovarian serous cystadenocarcinoma(64;7.87e-10)|all cancers(49;2.49e-09)|COAD - Colon adenocarcinoma(49;0.02)		TAACACTTACGGTGAAATTGT	0.398000													4	49					0.150653	0.153667	1	1	0
PMFBP1	83449	broad.mit.edu	37	16	72163076	72163076	+	Silent	SNP	T	T	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr16:72163076T>A	ENST00000537465.1	-	13	2012	c.1854A>T	c.(1852-1854)acA>acT	p.T618T	PMFBP1_ENST00000355636.6_Silent_p.T468T|PMFBP1_ENST00000237353.10_Silent_p.T613T			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	618										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				CCAGAAGCTTTGTGGCCTCCT	0.438000													23	300					0	0	1	0	0
DMRT3	58524	broad.mit.edu	37	9	990334	990334	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr9:990334C>A	ENST00000190165.2	+	2	786	c.748C>A	c.(748-750)Ccg>Acg	p.P250T		NM_021240.2	NP_067063.1	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor 3	250					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		AGCCAACAGACCGCCGCTTGA	0.587000													6	93					0.0215528	0.0229956	1	1	0
THOC6	79228	broad.mit.edu	37	16	3075959	3075959	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr16:3075959G>A	ENST00000326266.8	+	3	486	c.190G>A	c.(190-192)Gaa>Aaa	p.E64K	THOC6_ENST00000574549.1_Missense_Mutation_p.E40K|THOC6_ENST00000253952.9_Missense_Mutation_p.E64K|THOC6_ENST00000575576.1_Missense_Mutation_p.E40K	NM_024339.3	NP_077315.2	Q86W42	THOC6_HUMAN	THO complex 6 homolog (Drosophila)	64					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	RNA binding			central_nervous_system(1)|endometrium(4)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	13						AGCCAAAGAGGAAAGTAAGAA	0.557000													22	151					0	0	1	0	0
FAM154B	283726	broad.mit.edu	37	15	82575165	82575165	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr15:82575165G>T	ENST00000339465.5	+	3	1028	c.959G>T	c.(958-960)aGa>aTa	p.R320I	FAM154B_ENST00000565501.1_3'UTR|FAM154B_ENST00000427381.2_Missense_Mutation_p.R305I	NM_001008226.1	NP_001008227.1	Q658L1	F154B_HUMAN	family with sequence similarity 154, member B	320										autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(2)	19						AGCACTTTCAGATCTCACTAT	0.393000													7	72					0.0477658	0.0497154	1	1	0
POTEF	728378	broad.mit.edu	37	2	130832688	130832688	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr2:130832688C>A	ENST00000357462.5	-	15	2450	c.2357G>T	c.(2356-2358)tGg>tTg	p.W786L	POTEF_ENST00000409914.2_Missense_Mutation_p.W786L			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	786	Actin-like.					cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						GGTGTGGTGCCAGATCTTCTC	0.587000													14	110					2.31682e-05	3.01423e-05	1	1	0
SI	6476	broad.mit.edu	37	3	164737459	164737459	+	Silent	SNP	T	T	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr3:164737459T>C	ENST00000264382.3	-	28	3416	c.3354A>G	c.(3352-3354)gaA>gaG	p.E1118E		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1118	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ATGCTGTATGTTCCACTTCCC	0.448000										HNSCC(35;0.089)			4	74					0	0	1	0	0
RC3H1	149041	broad.mit.edu	37	1	173951987	173951987	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr1:173951987C>T	ENST00000367696.2	-	5	997	c.646G>A	c.(646-648)Gct>Act	p.A216T	RC3H1_ENST00000258349.4_Missense_Mutation_p.A216T|RC3H1_ENST00000367694.2_Missense_Mutation_p.A216T			Q5TC82	RC3H1_HUMAN	ring finger and CCCH-type domains 1	216					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	50						CTTGACAAAGCAGAACCATCT	0.423000													12	120					0	0	1	0	0
POTEF	728378	broad.mit.edu	37	2	130832687	130832687	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr2:130832687C>A	ENST00000357462.5	-	15	2451	c.2358G>T	c.(2356-2358)tgG>tgT	p.W786C	POTEF_ENST00000409914.2_Missense_Mutation_p.W786C			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	786	Actin-like.					cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						AGGTGTGGTGCCAGATCTTCT	0.587000													15	109					2.23348e-06	3.07859e-06	1	1	0
EXOSC8	11340	broad.mit.edu	37	13	37583435	37583435	+	Nonstop_Mutation	SNP	A	A	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr13:37583435A>T	ENST00000389704.3	+	11	1095	c.830A>T	c.(829-831)tAa>tTa	p.*277L		NM_181503.2	NP_852480.1	Q96B26	EXOS8_HUMAN	exosome component 8	0					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	AU-rich element binding|identical protein binding			biliary_tract(1)|breast(1)|kidney(2)|pancreas(1)|prostate(1)|skin(1)	7		Lung NSC(96;6.57e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)		all cancers(112;3.67e-07)|Epithelial(112;1.31e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00699)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0411)		AAACCCAAATAAACAGCCACC	0.323000													4	17					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37027567	37027567	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chrX:37027567C>A	ENST00000358047.3	+	1	1136	c.1084C>A	c.(1084-1086)Cgc>Agc	p.R362S		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	362										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TCCAGAGACTCGCGTATCTCC	0.647000													15	48					1.49906e-05	1.97041e-05	1	1	0
MAGEB6	158809	broad.mit.edu	37	X	26212753	26212753	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chrX:26212753C>A	ENST00000379034.1	+	2	939	c.790C>A	c.(790-792)Ctt>Att	p.L264I		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	264	MAGE.									breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						GTCCTACACCCTTGTCAGCAA	0.527000													12	66					9.05144e-12	1.49878e-11	1	1	0
HIST3H3	8290	broad.mit.edu	37	1	228612980	228612980	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr1:228612980G>T	ENST00000366696.1	-	1	46	c.47C>A	c.(46-48)gCg>gAg	p.A16E		NM_003493.2	NP_003484.1	Q16695	H31T_HUMAN	histone cluster 3, H3	16					nucleosome assembly|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			large_intestine(1)|lung(2)|prostate(2)|skin(1)	6		Prostate(94;0.0724)				CTTGCGCGGCGCCTTGCCACC	0.677000													17	82					1.37285e-15	2.36539e-15	1	1	0
SPHKAP	80309	broad.mit.edu	37	2	228855895	228855895	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr2:228855895C>A	ENST00000392056.3	-	11	4826	c.4780G>T	c.(4780-4782)Gca>Tca	p.A1594S	SPHKAP_ENST00000344657.5_Missense_Mutation_p.A1565S	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1594						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GGTCCAGATGCAGGTGCTGAG	0.567000													6	85					0.00116845	0.00135433	1	1	0
PEAR1	375033	broad.mit.edu	37	1	156873754	156873754	+	Silent	SNP	T	T	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr1:156873754T>A	ENST00000338302.3	+	3	261	c.36T>A	c.(34-36)gcT>gcA	p.A12A	PEAR1_ENST00000292357.7_Silent_p.A12A			Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	12						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(6)|lung(22)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)	43	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TTCTCCTGGCTGTGGGCCTGC	0.642000													22	127					0	0	1	0	0
WDR88	126248	broad.mit.edu	37	19	33623311	33623311	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr19:33623311C>A	ENST00000361680.2	+	1	314	c.236C>A	c.(235-237)cCg>cAg	p.P79Q	WDR88_ENST00000592765.1_Missense_Mutation_p.P79Q|WDR88_ENST00000355868.3_Missense_Mutation_p.P79Q			Q6ZMY6	WDR88_HUMAN	WD repeat domain 88	79										breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25	Esophageal squamous(110;0.137)					CACCAGGTGCCGGAGAAATTG	0.657000													5	62					3.59834e-05	4.58788e-05	1	1	0
TNR	7143	broad.mit.edu	37	1	175331934	175331934	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr1:175331934C>G	ENST00000367674.1	-	14	3427	c.2719G>C	c.(2719-2721)Gac>Cac	p.D907H	TNR_ENST00000263525.2_Missense_Mutation_p.D907H	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	907	Fibronectin type-III 7.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					ACTGAGCTGTCTAGTCGTCCC	0.498000													8	115					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37745022	37745022	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr9:37745022G>A	ENST00000539465.1	+	16	3586	c.2993G>A	c.(2992-2994)gGg>gAg	p.G998E	RP11-613M10.9_ENST00000540557.1_Intron|FRMPD1_ENST00000377765.3_Missense_Mutation_p.G998E			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	998						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		GACCTGGATGGGATTGCCCCC	0.547000													14	123					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26906191	26906191	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr5:26906191C>A	ENST00000231021.4	-	5	860	c.688G>T	c.(688-690)Gag>Tag	p.E230*		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	230	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						TGGTACTGCTCTCTATTTTCT	0.408000													17	104					3.52763e-06	4.83627e-06	1	1	0
FIGN	55137	broad.mit.edu	37	2	164466622	164466622	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr2:164466622C>A	ENST00000333129.3	-	3	2034	c.1720G>T	c.(1720-1722)Gcc>Tcc	p.A574S	FIGN_ENST00000409634.1_Intron	NM_018086.2	NP_060556.2	Q5HY92	FIGN_HUMAN	fidgetin	574						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(1)|prostate(2)|skin(1)	47						CGACACCTGGCCACAAGAAAA	0.478000													7	70					0.00198382	0.00226849	1	1	0
KLHL4	56062	broad.mit.edu	37	X	86887275	86887275	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chrX:86887275G>T	ENST00000373119.4	+	7	1535	c.1390G>T	c.(1390-1392)Ggc>Tgc	p.G464C	KLHL4_ENST00000373114.4_Missense_Mutation_p.G464C	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	464						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						CACCATGAATGGCCGTAGGCT	0.388000													5	38					0.000602214	0.000717592	1	1	0
FAM135B	51059	broad.mit.edu	37	8	139209823	139209823	+	Silent	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr8:139209823C>A	ENST00000395297.1	-	8	929	c.759G>T	c.(757-759)cgG>cgT	p.R253R		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	253										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GACGGAGACCCCGGTAAGCGT	0.607000										HNSCC(54;0.14)			23	74					3.7963e-18	6.86566e-18	1	1	0
BAP1	8314	broad.mit.edu	37	3	52437782	52437782	+	Nonsense_Mutation	SNP	G	G	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr3:52437782G>C	ENST00000460680.1	-	13	1850	c.1379C>G	c.(1378-1380)tCa>tGa	p.S460*	BAP1_ENST00000296288.5_Nonsense_Mutation_p.S442*	NM_004656.2	NP_004647.1	Q92560	BAP1_HUMAN	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)	460					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity	p.S460*(2)		NS(1)|breast(4)|endometrium(3)|eye(42)|kidney(60)|large_intestine(3)|lung(9)|ovary(4)|pleura(39)|prostate(4)|skin(9)|urinary_tract(2)	180				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		CAGAGGAATTGAGAGGTCCTT	0.587000			"""N, Mis, F, S, O"""		"""uveal melanoma, breast, NSCLC, RCC"""	"""mesothelioma, uveal melanoma"""							9	63					0	0	1	0	0
GSDMA	284110	broad.mit.edu	37	17	38122577	38122577	+	Silent	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr17:38122577G>T	ENST00000301659.4	+	3	397	c.279G>T	c.(277-279)gtG>gtT	p.V93V		NM_178171.4	NP_835465.2	Q96QA5	GSDMA_HUMAN	gasdermin A	93					apoptosis|induction of apoptosis	perinuclear region of cytoplasm				NS(1)|endometrium(2)|large_intestine(3)|lung(1)	7						AGGGAGATGTGGATGTACCAA	0.562000													7	93					0.00448238	0.00505755	1	1	0
C20orf26	26074	broad.mit.edu	37	20	20079339	20079339	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr20:20079339G>T	ENST00000245957.5	+	8	816	c.740G>T	c.(739-741)aGa>aTa	p.R247I	C20orf26_ENST00000389656.3_5'UTR|C20orf26_ENST00000377306.1_Missense_Mutation_p.R247I|C20orf26_ENST00000377309.2_5'UTR|C20orf26_ENST00000451767.2_Missense_Mutation_p.R247I	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	247										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		GTGTGCTCAAGAGTGAACATG	0.433000													21	147					8.04996e-18	1.43548e-17	1	1	0
AADACL2	344752	broad.mit.edu	37	3	151463350	151463350	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr3:151463350C>T	ENST00000356517.3	+	4	594	c.485C>T	c.(484-486)gCt>gTt	p.A162V		NM_207365.3	NP_997248.2	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2	162						extracellular region|integral to membrane	carboxylesterase activity	p.A162D(1)|p.A140D(1)		NS(1)|breast(1)|endometrium(2)|large_intestine(4)|liver(1)|lung(13)|skin(2)	24			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			GATGGCCTTGCTGCAGTCAAA	0.408000													28	226					0	0	1	0	0
IGKV3D-11	28876	broad.mit.edu	37	2	90211781	90211781	+	RNA	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr2:90211781G>T	ENST00000390277.2	+	0	139																											TGCTACTCTGGCTCCCAGGTG	0.498000													10	92					9.31168e-06	1.25634e-05	1	1	0
OR10H5	284433	broad.mit.edu	37	19	15905624	15905624	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr19:15905624G>T	ENST00000308940.8	+	1	864	c.766G>T	c.(766-768)Gcc>Tcc	p.A256S		NM_001004466.1	NP_001004466.1	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H, member 5	256					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(9)|ovary(1)	20						CTATGGCTTTGCCTCCGTCAT	0.577000													10	71					3.86212e-05	4.8997e-05	1	1	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29974802	29974802	+	RNA	SNP	T	T	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr6:29974802T>A	ENST00000376797.3	-	0	1346				ZNRD1-AS1_ENST00000448093.1_RNA|HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA																							ACTGACCGAGTGAACCTGCGG	0.672000													3	17					0	0	1	0	0
SLC16A7	9194	broad.mit.edu	37	12	60173372	60173372	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr12:60173372C>G	ENST00000261187.4	+	5	1513	c.1349C>G	c.(1348-1350)cCc>cGc	p.P450R	SLC16A7_ENST00000552024.1_Missense_Mutation_p.P450R|SLC16A7_ENST00000547379.1_Missense_Mutation_p.P450R|SLC16A7_ENST00000552432.1_Missense_Mutation_p.P450R|SLC16A7_ENST00000543448.1_Missense_Mutation_p.P351R	NM_001270622.1|NM_001270623.1|NM_004731.3	NP_001257551.1|NP_001257552.1|NP_004722.2	O60669	MOT2_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 7	450						integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(1)|large_intestine(14)|liver(2)|lung(11)|ovary(1)|skin(1)	30				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	GAATCTGAACCCTTGAGCAAA	0.403000													3	37					0	0	1	0	0
RXFP2	122042	broad.mit.edu	37	13	32376302	32376302	+	Silent	SNP	A	A	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr13:32376302A>T	ENST00000298386.2	+	18	2096	c.2025A>T	c.(2023-2025)atA>atT	p.I675I	RXFP2_ENST00000380314.1_Silent_p.I651I	NM_130806.3	NP_570718.1	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	675						integral to membrane|plasma membrane				cervix(1)|endometrium(2)|large_intestine(15)|lung(13)|prostate(1)|stomach(1)	33		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		CTTCCTGGATAGTGATTTTTT	0.348000													6	54					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164764801	164764801	+	Splice_Site	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr3:164764801C>A	ENST00000264382.3	-	16	1778		c.e16-1			NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)						carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TTGTACAGCTCTAAAAATAAA	0.294000										HNSCC(35;0.089)			7	45					8.12818e-05	0.000101602	1	1	0
WBP11P1	441818	broad.mit.edu	37	18	30093348	30093348	+	RNA	SNP	G	G	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr18:30093348G>C	ENST00000567636.1	+	0	1723					NR_003558.1																						CTGGCACGATGCACCCAGCTT	0.483000													5	62					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65103684	65103684	+	Silent	SNP	G	G	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr17:65103684G>A	ENST00000358691.5	-	31	5008	c.4842C>T	c.(4840-4842)agC>agT	p.S1614S	HELZ_ENST00000580168.1_Silent_p.S1615S	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					CTGCTGGTGGGCTTCTACTCT	0.458000													12	202					0	0	1	0	0
SIRT5	23408	broad.mit.edu	37	6	13588622	13588622	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr6:13588622G>T	ENST00000606117.1	+	4	471	c.175G>T	c.(175-177)Gct>Tct	p.A59S	SIRT5_ENST00000397350.2_Intron|SIRT5_ENST00000359782.3_Missense_Mutation_p.A59S|SIRT5_ENST00000379262.4_Missense_Mutation_p.A59S	NM_012241.4	NP_036373.1	Q9NXA8	SIRT5_HUMAN	sirtuin 5	59	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	11	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)	CATCTCAGGAGCTGGTGTTAG	0.408000													6	64					0.0215528	0.0229956	1	1	0
CT47B1	643311	broad.mit.edu	37	X	120007837	120007837	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chrX:120007837C>A	ENST00000371311.3	-	2	1067	c.813G>T	c.(811-813)gaG>gaT	p.E271D		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	271										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						CATCTTGGGCCTCTTCATCCC	0.443000													27	323					7.38237e-10	1.17656e-09	1	1	0
INTS4	92105	broad.mit.edu	37	11	77630019	77630019	+	Silent	SNP	T	T	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr11:77630019T>A	ENST00000534064.1	-	15	1804	c.1770A>T	c.(1768-1770)ccA>ccT	p.P590P		NM_033547.3	NP_291025.3	Q96HW7	INT4_HUMAN	integrator complex subunit 4	590					snRNA processing	integrator complex	protein binding		INTS4/GAB2(2)	NS(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(5)|upper_aerodigestive_tract(1)	32	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			GTTTTCTACCTGGTAACTAAG	0.443000													11	99					0	0	1	0	0
HIST1H2AG	8969	broad.mit.edu	37	6	27101068	27101068	+	Missense_Mutation	SNP	A	A	G			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr6:27101068A>G	ENST00000359193.2	+	1	237	c.218A>G	c.(217-219)gAc>gGc	p.D73G		NM_021064.4	NP_066408.1	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	73					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	17						GCGGCCCGCGACAACAAGAAG	0.657000													14	95					0	0	1	0	0
DIP2B	57609	broad.mit.edu	37	12	51072584	51072584	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr12:51072584G>T	ENST00000301180.5	+	8	1073	c.1039G>T	c.(1039-1041)Ggt>Tgt	p.G347C		NM_173602.2	NP_775873.2	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B (Drosophila)	347						nucleus	catalytic activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(15)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	60						GCAGCGCTGGGGTACCACTCA	0.532000													5	64					5.9392e-07	8.5084e-07	1	1	0
SNHG14	104472715	broad.mit.edu	37	15	25327735	25327735	+	RNA	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr15:25327735G>T	ENST00000546682.1	+	0	71				SNHG14_ENST00000549804.2_RNA	NR_003361.1																						GTACTTCCTAGGTGGTGTGGG	0.537000													3	16					0.004672	0.00522526	1	1	0
ZNF16	7564	broad.mit.edu	37	8	146156419	146156419	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr8:146156419C>A	ENST00000276816.4	-	4	1940	c.1754G>T	c.(1753-1755)aGc>aTc	p.S585I	ZNF16_ENST00000394909.2_Missense_Mutation_p.S585I	NM_001029976.2	NP_001025147.2	P17020	ZNF16_HUMAN	zinc finger protein 16	585					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(4)|large_intestine(5)|lung(9)|ovary(5)|prostate(1)|skin(1)|urinary_tract(1)	29	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		GAGATTTGAGCTTCGGTTGAA	0.473000													19	63					7.45023e-12	1.2417e-11	1	1	0
OXCT2	64064	broad.mit.edu	37	1	40236169	40236169	+	Silent	SNP	A	A	G			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr1:40236169A>G	ENST00000327582.5	-	1	851	c.759T>C	c.(757-759)gcT>gcC	p.A253A	BMP8B_ENST00000397360.2_Intron|BMP8B_ENST00000372827.3_Intron	NM_022120.1	NP_071403.1	Q9BYC2	SCOT2_HUMAN	3-oxoacid CoA transferase 2	253					ketone body catabolic process	microtubule-based flagellum|mitochondrion	3-oxoacid CoA-transferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|pancreas(1)|upper_aerodigestive_tract(1)	6	all_cancers(7;5.56e-14)|all_lung(5;3.88e-17)|all_epithelial(6;3.78e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;1.92e-17)|all cancers(16;4.03e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)		Succinic acid(DB00139)	CTGGGGGGAAAGCCCCCACCT	0.527000											OREG0013400	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	106					0	0	1	0	0
KLRC2	3822	broad.mit.edu	37	12	10583758	10583758	+	Silent	SNP	C	C	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr12:10583758C>T	ENST00000381902.2	-	6	660	c.654G>A	c.(652-654)caG>caA	p.Q218Q	KLRC2_ENST00000536833.2_Silent_p.Q159Q|KLRC2_ENST00000381901.1_Silent_p.Q218Q|NKG2-E_ENST00000539033.1_Intron	NM_002260.3	NP_002251.2	P26717	NKG2C_HUMAN	killer cell lectin-like receptor subfamily C, member 2	218	C-type lectin.				cellular defense response	integral to plasma membrane	sugar binding|transmembrane receptor activity			kidney(2)|large_intestine(1)|lung(6)|ovary(1)|skin(1)	11						AAGATCCACACTGGGCTGATT	0.328000													10	118					0	0	1	0	0
AKR1B10	57016	broad.mit.edu	37	7	134221871	134221871	+	Silent	SNP	T	T	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr7:134221871T>A	ENST00000359579.4	+	6	941	c.621T>A	c.(619-621)gtT>gtA	p.V207V		NM_020299.4	NP_064695.3	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10 (aldose reductase)	207					cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(9)|skin(5)	20						GCATCACCGTTACGGCCTACA	0.488000													6	36					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33616002	33616002	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr5:33616002C>A	ENST00000504830.1	-	15	2654	c.2319G>T	c.(2317-2319)caG>caT	p.Q773H	ADAMTS12_ENST00000504582.1_5'UTR|ADAMTS12_ENST00000352040.3_Missense_Mutation_p.Q688H	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	773	Spacer 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						TCCTGTCATACTGAAAGACAG	0.478000										HNSCC(64;0.19)			9	118					0.000442599	0.000537442	1	1	0
HCFC2	29915	broad.mit.edu	37	12	104497029	104497029	+	Missense_Mutation	SNP	A	A	G			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr12:104497029A>G	ENST00000229330.4	+	15	2461	c.2357A>G	c.(2356-2358)aAt>aGt	p.N786S	HCFC2_ENST00000550335.1_3'UTR	NM_013320.2	NP_037452.1	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	786					regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	35						CAAGGTAACAATAAGAAAGCA	0.343000													10	70					0	0	1	0	0
ANGPT4	51378	broad.mit.edu	37	20	868992	868992	+	Nonsense_Mutation	SNP	G	G	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr20:868992G>A	ENST00000381922.3	-	3	658	c.556C>T	c.(556-558)Cag>Tag	p.Q186*	ANGPT4_ENST00000546022.1_Nonsense_Mutation_p.Q186*	NM_015985.2	NP_057069.1	Q9Y264	ANGP4_HUMAN	angiopoietin 4	186					anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)	27						TGGAGCTTCTGCCTCTGTAGC	0.582000													15	63					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141777510	141777510	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr2:141777510C>A	ENST00000389484.3	-	12	2922	c.1951G>T	c.(1951-1953)Gtg>Ttg	p.V651L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	651					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GGATCCACCACAATTCCTCTG	0.348000										TSP Lung(27;0.18)			11	80					0.00829132	0.00915275	1	1	0
SUCO	51430	broad.mit.edu	37	1	172558600	172558600	+	Missense_Mutation	SNP	A	A	G			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr1:172558600A>G	ENST00000367723.3	+	17	2939	c.2815A>G	c.(2815-2817)Ata>Gta	p.I939V	SUCO_ENST00000263688.3_Missense_Mutation_p.I787V	NM_016227.2	NP_057311.2			SUN domain containing ossification factor																		CTTTAGTTCTATAGAGAAACC	0.333000													9	52					0	0	1	0	0
TET1	80312	broad.mit.edu	37	10	70404509	70404509	+	Missense_Mutation	SNP	A	A	G	rs141988009		TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr10:70404509A>G	ENST00000373644.4	+	4	2232	c.2023A>G	c.(2023-2025)Agt>Ggt	p.S675G		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	675					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						CATGGACTACAGTAGATGTGG	0.373000													6	47					0	0	1	0	0
CD3D	915	broad.mit.edu	37	11	118210617	118210617	+	Silent	SNP	G	G	A	rs111033581		TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr11:118210617G>A	ENST00000300692.4	-	3	415	c.279C>T	c.(277-279)tgC>tgT	p.C93C	CD3D_ENST00000529594.1_Silent_p.C20C|CD3D_ENST00000392884.2_Intron	NM_000732.4	NP_000723.1	P04234	CD3D_HUMAN	CD3d molecule, delta (CD3-TCR complex)	93					positive thymic T cell selection|T cell costimulation|T cell receptor signaling pathway	cytoplasm|integral to membrane	protein heterodimerization activity			large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(2)	9	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		CACAGCTCTGGCACACTGTGG	0.547000													7	56					0	0	1	0	0
SEMA3C	10512	broad.mit.edu	37	7	80430137	80430137	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr7:80430137C>A	ENST00000265361.3	-	10	1483	c.922G>T	c.(922-924)Gtg>Ttg	p.V308L	SEMA3C_ENST00000536800.1_Missense_Mutation_p.V160L|SEMA3C_ENST00000419255.2_Missense_Mutation_p.V308L|SEMA3C_ENST00000544525.1_Missense_Mutation_p.V326L	NM_006379.3	NP_006370.1	Q99985	SEM3C_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	308	Sema.				immune response|response to drug	membrane	receptor activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						AGCAGAAACACATCCTCTATA	0.279000													8	73					0.00448238	0.00505755	1	1	0
TACR3	6870	broad.mit.edu	37	4	104510989	104510989	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr4:104510989G>T	ENST00000304883.2	-	5	1388	c.1248C>A	c.(1246-1248)aaC>aaA	p.N416K	RP11-297P16.3_ENST00000512401.1_RNA|RP11-297P16.3_ENST00000502936.1_RNA	NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	416						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		TGTCTGCATCGTTGGGGTCAA	0.522000													23	198					1.85244e-09	2.88032e-09	1	1	0
IFI27L2	83982	broad.mit.edu	37	14	94595620	94595620	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr14:94595620C>T	ENST00000238609.3	-	2	115	c.16G>A	c.(16-18)Gct>Act	p.A6T	IFI27L2_ENST00000556727.1_5'UTR	NM_032036.2	NP_114425.1	Q9H2X8	I27L2_HUMAN	interferon, alpha-inducible protein 27-like 2	6						integral to membrane				breast(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|skin(1)	8						GCAGCAGCAGCTGCCCGTTCT	0.627000													3	29					0	0	1	0	0
OR2F2	135948	broad.mit.edu	37	7	143632554	143632554	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr7:143632554G>C	ENST00000408955.2	+	1	296	c.229G>C	c.(229-231)Gta>Cta	p.V77L		NM_001004685.1	NP_001004685.1	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F, member 2	77					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V77I(2)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(19)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	32	Melanoma(164;0.0903)					TGCCACAAGCGTAGTCCCCCA	0.512000													33	267					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101834266	101834266	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr5:101834266C>T	ENST00000506729.1	-	1	454	c.283G>A	c.(283-285)Gtc>Atc	p.V95I	SLCO6A1_ENST00000379810.1_Missense_Mutation_p.V95I|SLCO6A1_ENST00000513675.1_Missense_Mutation_p.V95I|SLCO6A1_ENST00000389019.3_Missense_Mutation_p.V95I|SLCO6A1_ENST00000514551.1_5'UTR|SLCO6A1_ENST00000379807.3_Missense_Mutation_p.V95I			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	95	Cys-rich.					integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		CAGGTGCTGACTAAGCAGCCC	0.498000													13	133					0	0	1	0	0
TGM4	7047	broad.mit.edu	37	3	44948575	44948575	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr3:44948575C>A	ENST00000296125.4	+	10	1278	c.1210C>A	c.(1210-1212)Cag>Aag	p.Q404K		NM_003241.3	NP_003232.2	P49221	TGM4_HUMAN	transglutaminase 4	404					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(9)|lung(21)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	38				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	GGTGAATGGGCAGGAGGAGTT	0.478000													20	131					4.96729e-08	7.32173e-08	1	1	0
KIAA1009	22832	broad.mit.edu	37	6	84834881	84834881	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr6:84834881C>A	ENST00000403245.3	-	27	4234	c.4120G>T	c.(4120-4122)Gac>Tac	p.D1374Y	KIAA1009_ENST00000461137.1_5'UTR|KIAA1009_ENST00000257766.4_Missense_Mutation_p.D1298Y	NM_014895.2	NP_055710.2	Q5TB80	QN1_HUMAN	KIAA1009	1374					cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	43		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		AATATTGAGTCTAGTTCTGTG	0.413000													7	37					0.00198382	0.00226849	1	1	0
DPEP3	64180	broad.mit.edu	37	16	68009843	68009843	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr16:68009843C>T	ENST00000268793.4	-	10	1740	c.1367G>A	c.(1366-1368)aGc>aAc	p.S456N		NM_001129758.1|NM_022357.3	NP_001123230.1|NP_071752.3	Q9H4B8	DPEP3_HUMAN	dipeptidase 3	431					meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(4)|endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)	20		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		GCAGGATGTGCTCAGTTGCCC	0.612000													6	45					0	0	1	0	0
MAN2A1	4124	broad.mit.edu	37	5	109159499	109159499	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr5:109159499G>T	ENST00000261483.4	+	16	3579	c.2527G>T	c.(2527-2529)Gac>Tac	p.D843Y		NM_002372.2	NP_002363.2	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	843					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		TTGCTTTTTTGACCATGTTAC	0.343000													10	76					1.08611e-07	1.59171e-07	1	1	0
C14orf166	51637	broad.mit.edu	37	14	52460441	52460441	+	Splice_Site	SNP	T	T	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr14:52460441T>C	ENST00000261700.3	+	3	352	c.186_splice	c.e3-1	p.Y63_splice	C14orf166_ENST00000556760.1_Splice_Site_p.Y63_splice	NM_016039.2	NP_057123.1	Q9Y224	CN166_HUMAN	chromosome 14 open reading frame 166	63						microtubule organizing center|nucleus|perinuclear region of cytoplasm|tRNA-splicing ligase complex	identical protein binding			endometrium(1)|large_intestine(3)|lung(2)	6	Breast(41;0.0639)|all_epithelial(31;0.101)					CCCCTCACAGTATCTCAGAGA	0.378000													14	53					0	0	1	0	0
SMPX	23676	broad.mit.edu	37	X	21755740	21755740	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chrX:21755740G>C	ENST00000379494.3	-	4	441	c.208C>G	c.(208-210)Cta>Gta	p.L70V	SMPX_ENST00000494525.1_5'UTR	NM_014332.2	NP_055147.1	Q9UHP9	SMPX_HUMAN	small muscle protein, X-linked	70					striated muscle contraction					breast(1)|endometrium(1)	2						ATTTCCGATAGATTGACTGCA	0.423000													14	47					0	0	1	0	0
NSUN4	387338	broad.mit.edu	37	1	46827252	46827252	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr1:46827252C>A	ENST00000474844.1	+	6	1539	c.889C>A	c.(889-891)Ctt>Att	p.L297I	NSUN4_ENST00000537428.1_Missense_Mutation_p.L248I|NSUN4_ENST00000498008.1_3'UTR|NSUN4_ENST00000536062.1_Missense_Mutation_p.L248I	NM_199044.3	NP_950245.2	Q96CB9	NSUN4_HUMAN	NOP2/Sun domain family, member 4	297							methyltransferase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)	8	Acute lymphoblastic leukemia(166;0.155)					GGCTGGACTCCTTGCCACCAA	0.498000													12	111					0.010729	0.0117421	1	1	0
MAP4	4134	broad.mit.edu	37	3	47917344	47917344	+	Missense_Mutation	SNP	T	T	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr3:47917344T>C	ENST00000426837.2	-	12	5675	c.5588A>G	c.(5587-5589)aAa>aGa	p.K1863R	MAP4_ENST00000462206.1_Intron|MAP4_ENST00000395734.3_Missense_Mutation_p.K718R|MAP4_ENST00000383737.4_Missense_Mutation_p.K446R|MAP4_ENST00000360240.6_Missense_Mutation_p.K718R|MAP4_ENST00000441748.2_Intron|MAP4_ENST00000264724.11_Missense_Mutation_p.K453R|MAP4_ENST00000420772.2_Intron			P27816	MAP4_HUMAN	microtubule-associated protein 4	718					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(2)	32				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		GGGCTGTGTTTTGGCTTTCGA	0.443000													12	152					0	0	1	0	0
TRPS1	7227	broad.mit.edu	37	8	116632032	116632032	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr8:116632032C>A	ENST00000395715.3	-	3	870	c.293G>T	c.(292-294)gGc>gTc	p.G98V	TRPS1_ENST00000519674.1_Missense_Mutation_p.G85V|TRPS1_ENST00000520276.1_Missense_Mutation_p.G89V|TRPS1_ENST00000220888.5_Missense_Mutation_p.G85V|TRPS1_ENST00000519076.1_Intron	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	85					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			ATAATTGAAGCCAGCCTTCTC	0.448000									Langer-Giedion syndrome				30	88					2.25844e-05	2.95334e-05	1	1	0
ENOX1	55068	broad.mit.edu	37	13	43896589	43896589	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr13:43896589C>T	ENST00000261488.6	-	11	1769	c.1192G>A	c.(1192-1194)Gaa>Aaa	p.E398K	ENOX1_ENST00000412891.1_Missense_Mutation_p.E398K|ENOX1_ENST00000540032.1_Missense_Mutation_p.E211K	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	398					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		TCCATTTCTTCTTCGCGGCGG	0.478000													9	68					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63547773	63547773	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr18:63547773C>G	ENST00000397968.2	+	12	2427	c.2001C>G	c.(1999-2001)gaC>gaG	p.D667E	CDH7_ENST00000323011.3_Missense_Mutation_p.D667E	NM_004361.2	NP_004352.2	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	667					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				AAGCGTTTGACATGGCTGCAC	0.478000													8	70					0	0	1	0	0
OR5H14	403273	broad.mit.edu	37	3	97868667	97868667	+	Silent	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr3:97868667C>A	ENST00000437310.1	+	1	498	c.438C>A	c.(436-438)atC>atA	p.I146I		NM_001005514.1	NP_001005514.1	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H, member 14	146					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						GGCTATTAATCTTGTCATATG	0.383000													18	224					8.00594e-06	1.08591e-05	1	1	0
TMEM215	401498	broad.mit.edu	37	9	32784844	32784844	+	Silent	SNP	T	T	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr9:32784844T>C	ENST00000342743.5	+	2	1028	c.663T>C	c.(661-663)taT>taC	p.Y221Y		NM_212558.2	NP_997723.2	Q68D42	TM215_HUMAN	transmembrane protein 215	221						integral to membrane				endometrium(4)|kidney(1)|large_intestine(3)|lung(2)|prostate(2)	12						ACTGTTGTTATATCAATCAGA	0.493000													7	93					0	0	1	0	0
ESYT1	23344	broad.mit.edu	37	12	56531108	56531108	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr12:56531108C>G	ENST00000394048.5	+	17	2153	c.1889C>G	c.(1888-1890)gCc>gGc	p.A630G	ESYT1_ENST00000267113.4_Missense_Mutation_p.A640G|ESYT1_ENST00000541590.1_Missense_Mutation_p.A640G	NM_001184796.1|NM_015292.2	NP_001171725.1|NP_056107.1	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	630						integral to membrane				breast(2)|endometrium(2)|large_intestine(4)|lung(10)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	28						AGTGTGGATGCCCCACCTCGA	0.542000													8	63					0	0	1	0	0
ZNF79	7633	broad.mit.edu	37	9	130207370	130207370	+	Missense_Mutation	SNP	A	A	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr9:130207370A>C	ENST00000342483.5	+	5	1797	c.1391A>C	c.(1390-1392)cAg>cCg	p.Q464P	ZNF79_ENST00000543471.1_Missense_Mutation_p.Q440P	NM_007135.2	NP_009066.2	Q15937	ZNF79_HUMAN	zinc finger protein 79	464					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|stomach(2)	28						AGTCAGCATCAGAGAATCCAC	0.512000													12	178					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38266311	38266311	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr13:38266311G>T	ENST00000379705.3	-	4	1916	c.1059C>A	c.(1057-1059)agC>agA	p.S353R	TRPC4_ENST00000379673.2_Missense_Mutation_p.S353R|TRPC4_ENST00000426868.2_Missense_Mutation_p.S353R|TRPC4_ENST00000379681.3_Missense_Mutation_p.S353R|TRPC4_ENST00000447043.1_Missense_Mutation_p.S353R|TRPC4_ENST00000355779.2_Missense_Mutation_p.S353R|TRPC4_ENST00000338947.5_Missense_Mutation_p.S180R|TRPC4_ENST00000379679.1_Missense_Mutation_p.S180R|TRPC4_ENST00000358477.2_Missense_Mutation_p.S353R			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	353					axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		GTCCAAGTGGGCTTTTGGGAG	0.463000													7	45					2.0095e-06	2.7849e-06	1	1	0
PEX5L	51555	broad.mit.edu	37	3	179615999	179615999	+	Silent	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr3:179615999G>T	ENST00000467460.1	-	3	459	c.129C>A	c.(127-129)gcC>gcA	p.A43A	PEX5L_ENST00000472994.1_Intron|PEX5L_ENST00000468741.1_Intron|PEX5L_ENST00000465751.1_Silent_p.A19A|PEX5L_ENST00000464614.1_5'UTR|PEX5L_ENST00000263962.8_Silent_p.A41A|PEX5L_ENST00000485199.1_Intron|PEX5L_ENST00000476138.1_5'UTR	NM_001256751.1|NM_016559.2	NP_001243680.1|NP_057643.1	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	43					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			TCATCACCATGGCAACAGCCT	0.453000													10	95					5.16669e-11	8.44554e-11	1	1	0
ADH1A	124	broad.mit.edu	37	4	100208112	100208112	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr4:100208112G>T	ENST00000209668.2	-	3	267	c.154C>A	c.(154-156)Cac>Aac	p.H52N	RP11-696N14.1_ENST00000500358.2_RNA|ADH1A_ENST00000511656.1_5'UTR	NM_000667.3	NP_000658.1	P07327	ADH1A_HUMAN	alcohol dehydrogenase 1A (class I), alpha polypeptide	52					ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)	25				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	CTAACCACGTGGTCATCTGTG	0.473000													8	167					0.000274275	0.000336251	1	1	0
SIPA1L2	57568	broad.mit.edu	37	1	232581314	232581314	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr1:232581314C>A	ENST00000366630.1	-	10	3672	c.3314G>T	c.(3313-3315)cGa>cTa	p.R1105L	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.R1105L|SIPA1L2_ENST00000308942.4_Missense_Mutation_p.R179L			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	1105					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GGAGGTGCTTCGAGGAATGGC	0.642000													10	66					0.00621372	0.00688912	1	1	0
HLA-A	3105	broad.mit.edu	37	6	29910693	29910693	+	Missense_Mutation	SNP	A	A	G	rs41559716	by1000genomes	TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr6:29910693A>G	ENST00000396634.1	+	4	574	c.233A>G	c.(232-234)cAg>cGg	p.Q78R	HLA-A_ENST00000376806.5_Missense_Mutation_p.Q78R|HLA-A_ENST00000376809.5_Missense_Mutation_p.Q78R|HLA-A_ENST00000376802.2_Missense_Mutation_p.Q78R			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	78	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity	p.Q78R(2)		central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						TGGATAGAGCAGGAGGGGCCG	0.657000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			4	26					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160044967	160044967	+	Silent	SNP	A	A	G			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr5:160044967A>G	ENST00000327245.5	-	16	3276	c.2430T>C	c.(2428-2430)aaT>aaC	p.N810N	CTC-348L5.1_ENST00000523598.1_RNA	NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	810					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCTTTTCCATATTAATGTCAG	0.468000													5	70					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3239242	3239242	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chrX:3239242G>T	ENST00000217939.6	-	5	4638	c.4484C>A	c.(4483-4485)tCc>tAc	p.S1495Y		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1495						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TGTGGATGGGGACGAGGATGC	0.478000													5	56					0.000602214	0.000717592	1	1	0
RP11-478B9.1	0	broad.mit.edu	37	12	45457840	45457840	+	RNA	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr12:45457840G>T	ENST00000548424.1	+	0	448																											TTAGGCGAAAGGTCAGAAGAG	0.453000													10	115					0.000442599	0.000537442	1	1	0
AKNA	80709	broad.mit.edu	37	9	117113215	117113215	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr9:117113215C>T	ENST00000307564.4	-	15	3306	c.3145G>A	c.(3145-3147)Gcc>Acc	p.A1049T	AKNA_ENST00000374075.5_Missense_Mutation_p.A968T|AKNA_ENST00000374088.3_Missense_Mutation_p.A1049T|AKNA_ENST00000223791.3_Missense_Mutation_p.A509T	NM_030767.4	NP_110394.3	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	1049					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						GCGGCAGGGGCGGGGGCTGGG	0.612000													7	66					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41584821	41584821	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr8:41584821C>A	ENST00000396942.1	-	5	456	c.373G>T	c.(373-375)Gaa>Taa	p.E125*	ANK1_ENST00000396945.1_Nonsense_Mutation_p.E125*|ANK1_ENST00000265709.8_Nonsense_Mutation_p.E158*|ANK1_ENST00000379758.2_Nonsense_Mutation_p.E125*|ANK1_ENST00000352337.4_Nonsense_Mutation_p.E125*|ANK1_ENST00000347528.4_Nonsense_Mutation_p.E125*|ANK1_ENST00000289734.7_Nonsense_Mutation_p.E125*			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	125	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TTAACCACTTCCAAGTGGTTC	0.443000													5	69					1.23904e-05	1.63707e-05	1	1	0
STON2	85439	broad.mit.edu	37	14	81744537	81744537	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr14:81744537C>A	ENST00000555447.1	-	6	1530	c.1118G>T	c.(1117-1119)aGc>aTc	p.S373I	STON2_ENST00000267540.2_Missense_Mutation_p.S373I	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	373					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		CTGGGTTTTGCTTGAATCATC	0.453000													16	90					1.37285e-15	2.36539e-15	1	1	0
HBG2	3048	broad.mit.edu	37	11	5274542	5274542	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr11:5274542C>A	ENST00000380259.2	-	8	1649	c.409G>T	c.(409-411)Gga>Tga	p.G137*	HBG2_ENST00000336906.4_Nonsense_Mutation_p.G137*|HBG2_ENST00000380252.1_Nonsense_Mutation_p.G127*					hemoglobin, gamma G											endometrium(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	13		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGGCCACTCCAGTCACCATC	0.498000													11	57					1.58986e-06	2.21538e-06	1	1	0
APOB	338	broad.mit.edu	37	2	21228400	21228400	+	Silent	SNP	G	G	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr2:21228400G>A	ENST00000233242.1	-	26	11467	c.11340C>T	c.(11338-11340)gcC>gcT	p.A3780A		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3780					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GTAGGTTGAGGGCAAATGATG	0.393000													20	196					0	0	1	0	0
RSPO4	343637	broad.mit.edu	37	20	944660	944660	+	Silent	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr20:944660G>T	ENST00000217260.4	-	4	609	c.513C>A	c.(511-513)ggC>ggA	p.G171G	RSPO4_ENST00000400634.2_Intron	NM_001029871.3	NP_001025042.2	Q2I0M5	RSPO4_HUMAN	R-spondin 4	171	TSP type-1.				Wnt receptor signaling pathway	extracellular region	heparin binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7						GCCCAGCCCGGCCAGCCTCTC	0.662000													13	50					4.3838e-07	6.35153e-07	1	1	0
SNTB1	6641	broad.mit.edu	37	8	121587351	121587351	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr8:121587351G>A	ENST00000395601.3	-	5	1525	c.1111C>T	c.(1111-1113)Cac>Tac	p.H371Y	SNTB1_ENST00000519177.1_5'UTR|SNTB1_ENST00000517992.1_Missense_Mutation_p.H371Y	NM_021021.3	NP_066301.1	Q13884	SNTB1_HUMAN	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)	371	PH 2.				muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(6)	24	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			GGGTATGTGTGAACTGGGCTG	0.458000													8	122					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88965917	88965917	+	Silent	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr7:88965917C>A	ENST00000333190.4	+	4	4230	c.3621C>A	c.(3619-3621)acC>acA	p.T1207T		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1207						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CTTCTATCACCACCATCCACC	0.498000										HNSCC(36;0.09)			14	143					0.000151284	0.000188183	1	1	0
OR5W2	390148	broad.mit.edu	37	11	55681634	55681634	+	Missense_Mutation	SNP	T	T	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr11:55681634T>C	ENST00000344514.1	-	1	424	c.425A>G	c.(424-426)tAt>tGt	p.Y142C		NM_001001960.1	NP_001001960.1	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W, member 2	142					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(28)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						CAAGAGTAGATAGCACACTCT	0.463000													9	76					0	0	1	0	0
CHFR	55743	broad.mit.edu	37	12	133433133	133433133	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr12:133433133G>A	ENST00000266880.7	-	11	1249	c.1186C>T	c.(1186-1188)Cgg>Tgg	p.R396W	CHFR_ENST00000537522.1_Missense_Mutation_p.R18W|CHFR_ENST00000315585.7_Missense_Mutation_p.R355W|CHFR_ENST00000450056.2_Missense_Mutation_p.R384W|CHFR_ENST00000443047.2_Missense_Mutation_p.R304W|CHFR_ENST00000541837.2_5'UTR|CHFR_ENST00000432561.2_Missense_Mutation_p.R396W			Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase	396					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		GAAAAAGACCGCCTGACTTTG	0.468000													27	269					0	0	1	0	0
DCSTAMP	81501	broad.mit.edu	37	8	105361365	105361365	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr8:105361365C>A	ENST00000297581.2	+	2	634	c.585C>A	c.(583-585)agC>agA	p.S195R	DPYS_ENST00000521601.1_Intron|DCSTAMP_ENST00000517991.1_Missense_Mutation_p.S195R	NM_030788.3	NP_110415.1	Q9H295	TM7S4_HUMAN	dendrocyte expressed seven transmembrane protein	195					osteoclast differentiation	cell surface|integral to membrane|plasma membrane											AAGTCCTGAGCGTCTTGTACC	0.547000													28	109					1.68575e-08	2.54359e-08	1	1	0
CCDC22	28952	broad.mit.edu	37	X	49093573	49093573	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chrX:49093573A>T	ENST00000376227.3	+	2	241	c.71A>T	c.(70-72)cAg>cTg	p.Q24L	CCDC22_ENST00000496651.1_3'UTR	NM_014008.3	NP_054727.1	O60826	CCD22_HUMAN	coiled-coil domain containing 22	24										NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(2)|skin(1)	18						CCAGATGTGCAGACCTTGCGC	0.597000													6	15					0	0	1	0	0
ZNF572	137209	broad.mit.edu	37	8	125989176	125989176	+	Silent	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr8:125989176G>T	ENST00000319286.5	+	3	820	c.666G>T	c.(664-666)ggG>ggT	p.G222G		NM_152412.2	NP_689625.2	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	222					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	31	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CCGAGTGTGGGAAGAGATTCA	0.453000										HNSCC(60;0.17)			20	88					1.00905e-13	1.70402e-13	1	1	0
LOX	4015	broad.mit.edu	37	5	121405749	121405749	+	Splice_Site	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr5:121405749G>T	ENST00000231004.4	-	6	1545	c.1247_splice	c.e6+1	p.P416_splice	SRFBP1_ENST00000504881.1_Intron|LOX_ENST00000513319.1_5'UTR	NM_001178102.1|NM_002317.5	NP_001171573.1|NP_002308.2	P28300	LYOX_HUMAN	lysyl oxidase	416	Lysyl-oxidase like.				protein modification process	extracellular space	copper ion binding|protein-lysine 6-oxidase activity			endometrium(1)|lung(6)|prostate(1)	8		all_cancers(142;0.0124)|Prostate(80;0.0322)|Ovarian(225;0.0814)|Breast(839;0.143)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;2.14e-11)|OV - Ovarian serous cystadenocarcinoma(64;7.87e-10)|all cancers(49;2.49e-09)|COAD - Colon adenocarcinoma(49;0.02)		AACACTTACGGTGAAATTGTG	0.398000													4	52					0.150653	0.153667	1	1	0
ATP6V1H	51606	broad.mit.edu	37	8	54714367	54714367	+	Silent	SNP	C	C	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr8:54714367C>T	ENST00000355221.3	-	7	1174	c.615G>A	c.(613-615)ggG>ggA	p.G205G	ATP6V1H_ENST00000359530.2_Silent_p.G223G|ATP6V1H_ENST00000520188.1_Silent_p.G183G|ATP6V1H_ENST00000396774.2_Silent_p.G223G	NM_213619.2	NP_998784.1	Q9UI12	VATH_HUMAN	ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H	223					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|endocytosis|insulin receptor signaling pathway|interspecies interaction between organisms|regulation of defense response to virus by virus|transferrin transport|vacuolar acidification|viral reproduction	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase, V1 domain	enzyme regulator activity|protein binding|proton-transporting ATPase activity, rotational mechanism			endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|urinary_tract(1)	18		all_epithelial(80;0.0487)|Lung NSC(129;0.109)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;2.79e-06)|Epithelial(17;0.000629)|all cancers(17;0.00359)			ACCAATTTACCCCATCTGCTT	0.423000													4	43					0	0	1	0	0
KCNV1	27012	broad.mit.edu	37	8	110980597	110980597	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr8:110980597A>T	ENST00000524391.1	-	4	2255	c.1223T>A	c.(1222-1224)gTg>gAg	p.V408E	KCNV1_ENST00000297404.1_Missense_Mutation_p.V408E			Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	408						voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(20)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			CATGAAGGCCACGATTTTGCC	0.473000													31	99					0	0	1	0	0
EPHB6	2051	broad.mit.edu	37	7	142561841	142561841	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr7:142561841G>C	ENST00000392957.2	+	7	1070	c.283G>C	c.(283-285)Gtg>Ctg	p.V95L	EPHB6_ENST00000442129.1_Missense_Mutation_p.V95L|EPHB6_ENST00000411471.2_Intron	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	95						extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					GACACACTTTGTGGAGCGGCG	0.657000													25	186					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114179473	114179473	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr4:114179473G>T	ENST00000357077.4	+	13	1345	c.1292G>T	c.(1291-1293)gGc>gTc	p.G431V	ANK2_ENST00000264366.6_Missense_Mutation_p.G431V|ANK2_ENST00000394537.3_Missense_Mutation_p.G431V|ANK2_ENST00000506722.1_Missense_Mutation_p.G410V	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	431					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TCGCAGTCTGGCCTCACACCA	0.488000													5	82					0.014758	0.016014	1	1	0
GBA2	57704	broad.mit.edu	37	9	35737761	35737761	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr9:35737761G>A	ENST00000378094.4	-	16	3002	c.2489C>T	c.(2488-2490)gCt>gTt	p.A830V	GBA2_ENST00000378088.1_Missense_Mutation_p.A131V|GBA2_ENST00000545786.1_Missense_Mutation_p.A836V|GBA2_ENST00000378103.3_Missense_Mutation_p.A830V			Q9HCG7	GBA2_HUMAN	glucosidase, beta (bile acid) 2	830					bile acid metabolic process|glucosylceramide catabolic process|O-glycoside catabolic process	integral to membrane|microsome|plasma membrane|smooth endoplasmic reticulum	beta-glucosidase activity|glucosylceramidase activity			NS(1)|kidney(3)|large_intestine(5)|lung(5)|ovary(4)|skin(3)	21	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GATCATGGTAGCTGCCAGCCC	0.522000													9	92					0	0	1	0	0
CHRNA9	55584	broad.mit.edu	37	4	40339331	40339331	+	Silent	SNP	C	C	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr4:40339331C>T	ENST00000310169.2	+	3	454	c.315C>T	c.(313-315)atC>atT	p.I105I	CHRNA9_ENST00000502377.1_3'UTR	NM_017581.3	NP_060051.2	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9 (neuronal)	105					elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(4)|stomach(1)	33					Nicotine(DB00184)	TAGACTCCATCAGGATCCCCA	0.483000													4	46					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27504602	27504602	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr16:27504602C>G	ENST00000356183.4	-	17	2809	c.2794G>C	c.(2794-2796)Gaa>Caa	p.E932Q	GTF3C1_ENST00000561623.1_Missense_Mutation_p.E932Q	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	932						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						TTCAGAAATTCCTCCAGGTTG	0.552000													6	66					0	0	1	0	0
KIAA0586	9786	broad.mit.edu	37	14	59014653	59014653	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr14:59014653G>T	ENST00000354386.6	+	34	5138	c.4894G>T	c.(4894-4896)Ggg>Tgg	p.G1632W	KIAA0586_ENST00000423743.3_3'UTR|KIAA0586_ENST00000261244.5_3'UTR|KIAA0586_ENST00000556134.1_3'UTR	NM_001244189.1	NP_001231118.1	E9PGW8	E9PGW8_HUMAN	KIAA0586	0										endometrium(4)|kidney(6)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CCTTCTGAACGGGAAGAGACA	0.483000													7	86					0.0381472	0.039867	1	1	0
P2RY8	286530	broad.mit.edu	37	X	1585173	1585173	+	Silent	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chrX:1585173C>A	ENST00000381297.4	-	2	489	c.279G>T	c.(277-279)gtG>gtT	p.V93V		NM_178129.4	NP_835230.1	Q86VZ1	P2RY8_HUMAN	purinergic receptor P2Y, G-protein coupled, 8	93						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TGCAAAGCAGCACCCCGAATA	0.547000			T	CRLF2	"""B-ALL, Downs associated ALL"""								5	33					3.59834e-05	4.58788e-05	1	1	0
TBC1D23	55773	broad.mit.edu	37	3	100009532	100009532	+	Missense_Mutation	SNP	A	A	G			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr3:100009532A>G	ENST00000394144.4	+	5	594	c.587A>G	c.(586-588)tAt>tGt	p.Y196C	TBC1D23_ENST00000486274.1_3'UTR|TBC1D23_ENST00000344949.5_Missense_Mutation_p.Y196C|TBC1D23_ENST00000475134.1_Missense_Mutation_p.Y59C	NM_001199198.2	NP_001186127.1	Q9NUY8	TBC23_HUMAN	TBC1 domain family, member 23	196	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)|endometrium(1)|large_intestine(7)|liver(1)|lung(10)|ovary(1)|prostate(2)|skin(2)	25						CCAGACTCCTATGCACTCAAC	0.353000													12	113					0	0	1	0	0
NLRP1	22861	broad.mit.edu	37	17	5462709	5462709	+	Missense_Mutation	SNP	G	G	C	rs150958602		TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr17:5462709G>C	ENST00000345221.3	-	4	1861	c.1307C>G	c.(1306-1308)gCg>gGg	p.A436G	NLRP1_ENST00000354411.3_Missense_Mutation_p.A436G|NLRP1_ENST00000572272.1_Missense_Mutation_p.A436G|NLRP1_ENST00000269280.4_Missense_Mutation_p.A436G|NLRP1_ENST00000571307.1_5'UTR|NLRP1_ENST00000262467.5_Missense_Mutation_p.A436G|NLRP1_ENST00000577119.1_Missense_Mutation_p.A436G	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	436	NACHT.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				CAGTGCATCCGCCGGCTGTGG	0.582000													5	35					0	0	1	0	0
KRR1	11103	broad.mit.edu	37	12	75900384	75900384	+	Silent	SNP	T	T	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr12:75900384T>C	ENST00000229214.4	-	4	422	c.399A>G	c.(397-399)gtA>gtG	p.V133V	KRR1_ENST00000438169.2_Silent_p.V133V	NM_007043.6	NP_008974.5	Q13601	KRR1_HUMAN	KRR1, small subunit (SSU) processome component, homolog (yeast)	133					rRNA processing	nucleolus|ribonucleoprotein complex	RNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(1)|ovary(1)|pancreas(1)|urinary_tract(1)	11						GAAGAATTCGTACTGCCTTTT	0.323000													5	44					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23866220	23866220	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr14:23866220C>T	ENST00000405093.3	-	18	2190	c.2120G>A	c.(2119-2121)tGc>tAc	p.C707Y	MYH6_ENST00000356287.3_Missense_Mutation_p.C707Y	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	707	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GCCCTTCCTGCAGATGCGGAT	0.642000													6	57					0	0	1	0	0
UEVLD	55293	broad.mit.edu	37	11	18587907	18587907	+	Silent	SNP	T	T	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr11:18587907T>A	ENST00000396197.3	-	5	508	c.480A>T	c.(478-480)gcA>gcT	p.A160A	UEVLD_ENST00000320750.6_Silent_p.A138A|UEVLD_ENST00000379387.4_Silent_p.A138A|UEVLD_ENST00000540666.1_5'UTR|UEVLD_ENST00000541984.1_Intron|UEVLD_ENST00000535484.1_Silent_p.A122A|UEVLD_ENST00000543987.1_Silent_p.A160A|UEVLD_ENST00000300038.7_Silent_p.A160A	NM_001040697.2|NM_001261384.1	NP_001035787.1|NP_001248313.1	Q8IX04	UEVLD_HUMAN	UEV and lactate/malate dehyrogenase domains	160					cellular carbohydrate metabolic process|protein modification process|protein transport		binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8						CAGTGATTTTTGCAATATAGG	0.368000													10	65					0	0	1	0	0
PGM5P2	595135	broad.mit.edu	37	9	69127026	69127026	+	RNA	SNP	T	T	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr9:69127026T>A	ENST00000591037.1	-	0	532					NR_002836.2																						GGGCAGTGGCTGGCTGTTAGA	0.468000													4	28					0	0	1	0	0
CDC20B	166979	broad.mit.edu	37	5	54416314	54416314	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr5:54416314C>A	ENST00000296733.1	-	10	1454	c.1280G>T	c.(1279-1281)cGc>cTc	p.R427L	CDC20B_ENST00000334206.5_3'UTR|CDC20B_ENST00000381375.2_Missense_Mutation_p.R427L|CDC20B_ENST00000322374.6_Intron	NM_001170402.1|NM_152623.2	NP_001163873.1|NP_689836.2	Q86Y33	CD20B_HUMAN	cell division cycle 20B	427										kidney(1)|large_intestine(5)|lung(7)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	19		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			GATGTGTAAGCGTCCATCCTT	0.468000													10	121					9.70103e-10	1.5365e-09	1	1	0
LIPI	149998	broad.mit.edu	37	21	15537668	15537668	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr21:15537668C>A	ENST00000344577.2	-	6	865	c.840G>T	c.(838-840)ttG>ttT	p.L280F	LIPI_ENST00000536861.1_Missense_Mutation_p.L259F	NM_198996.2	NP_945347.1	Q6XZB0	LIPI_HUMAN	lipase, member I	259					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			endometrium(1)|kidney(13)|large_intestine(9)|liver(3)|lung(24)|ovary(3)|urinary_tract(1)	54				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		ATGCCATGAACAAGTGAACTG	0.333000													9	59					7.48243e-07	1.06593e-06	1	1	0
LSAMP	4045	broad.mit.edu	37	3	115529217	115529217	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr3:115529217C>T	ENST00000490035.1	-	7	1463	c.964G>A	c.(964-966)Gta>Ata	p.V322I	LSAMP_ENST00000539563.1_Missense_Mutation_p.V342I	NM_002338.3	NP_002329.2	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	322					cell adhesion|nervous system development	anchored to membrane|plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|kidney(1)|large_intestine(4)|lung(14)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		CACAGTGGTACGGCCAGACTG	0.423000													3	24					0	0	1	0	0
TUBB6	84617	broad.mit.edu	37	18	12325224	12325224	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr18:12325224G>T	ENST00000317702.5	+	4	670	c.436G>T	c.(436-438)Ggc>Tgc	p.G146C	TUBB6_ENST00000586653.1_3'UTR|TUBB6_ENST00000591909.1_Intron|TUBB6_ENST00000591208.1_Missense_Mutation_p.Q118H|TUBB6_ENST00000590967.1_Intron			Q9BUF5	TBB6_HUMAN	tubulin, beta 6 class V	146					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)	14				READ - Rectum adenocarcinoma(1;0.0649)		CACGGGCTCAGGCATGGGCAC	0.657000													6	65					0.0293803	0.0312166	1	1	0
IRF9	10379	broad.mit.edu	37	14	24620756	24620756	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr14:24620756G>T	ENST00000558468.1	+	2	225	c.225G>T	c.(223-225)caG>caT	p.Q75H	RNF31_ENST00000324103.6_Missense_Mutation_p.Q600H|RNF31_ENST00000382687.3_Missense_Mutation_p.Q449H|RNF31_ENST00000559275.1_Missense_Mutation_p.Q449H																							CATTGTTCCAGCACGGAGGTG	0.627000													4	46					0.150653	0.153667	1	1	0
GPR142	350383	broad.mit.edu	37	17	72368685	72368685	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr17:72368685G>A	ENST00000335666.4	+	4	1383	c.1335G>A	c.(1333-1335)atG>atA	p.M445I		NM_181790.1	NP_861455.1	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	445						cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(21)|ovary(2)|prostate(1)|skin(4)	35						CAGAGGGCATGGCGGCGAAGC	0.627000													5	43					0	0	1	0	0
HOXD10	3236	broad.mit.edu	37	2	176981904	176981904	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr2:176981904A>T	ENST00000249501.4	+	1	598	c.343A>T	c.(343-345)Atg>Ttg	p.M115L	HOXD10_ENST00000490088.2_Intron	NM_002148.3	NP_002139.2	P28358	HXD10_HUMAN	homeobox D10	115						nucleus	sequence-specific DNA binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		CAATTGCTGCATGTATTCTGA	0.502000													15	157					0	0	1	0	0
PPM1A	5494	broad.mit.edu	37	14	60749727	60749727	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr14:60749727A>T	ENST00000395076.4	+	2	736	c.306A>T	c.(304-306)agA>agT	p.R102S	PPM1A_ENST00000325658.3_Missense_Mutation_p.R102S|PPM1A_ENST00000325642.3_Missense_Mutation_p.R175S|PPM1A_ENST00000529574.1_Missense_Mutation_p.R102S	NM_021003.4	NP_066283.1	P35813	PPM1A_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1A	102					cell cycle arrest|insulin receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein dephosphorylation|Wnt receptor signaling pathway	cytosol|nucleus|protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein serine/threonine phosphatase activity|signal transducer activity			cervix(1)|endometrium(1)|large_intestine(8)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(108;0.046)		ATGGAATCAGAACAGGTTTTC	0.403000													13	136					0	0	1	0	0
CPED1	79974	broad.mit.edu	37	7	120906374	120906374	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr7:120906374G>T	ENST00000310396.5	+	19	2871	c.2404G>T	c.(2404-2406)Ggc>Tgc	p.G802C		NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		GAAAGTACATGGCACTAAATT	0.398000													19	181					1.00905e-13	1.70402e-13	1	1	0
EPAS1	2034	broad.mit.edu	37	2	46603775	46603775	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr2:46603775G>T	ENST00000263734.3	+	9	1642	c.1132G>T	c.(1132-1134)Ggc>Tgc	p.G378C		NM_001430.4	NP_001421.2	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	378					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			TGATAGCAGTGGCAAGGGGGC	0.542000													19	148					5.3912e-06	7.35164e-06	1	1	0
KCNH6	81033	broad.mit.edu	37	17	61607856	61607856	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr17:61607856C>T	ENST00000583023.1	+	4	639	c.628C>T	c.(628-630)Cat>Tat	p.H210Y	KCNH6_ENST00000580652.1_Missense_Mutation_p.H210Y|KCNH6_ENST00000581784.1_Missense_Mutation_p.H210Y|KCNH6_ENST00000314672.5_Missense_Mutation_p.H210Y|KCNH6_ENST00000456941.2_Missense_Mutation_p.H210Y	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	210					regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	CATCGCGCCCCATAAGGTGGT	0.607000													6	78					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138452270	138452270	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr4:138452270G>T	ENST00000344876.4	-	1	1359	c.973C>A	c.(973-975)Cag>Aag	p.Q325K	PCDH18_ENST00000507846.1_Missense_Mutation_p.Q105K|PCDH18_ENST00000412923.2_Missense_Mutation_p.Q325K|PCDH18_ENST00000510305.1_Intron|PCDH18_ENST00000511115.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	325	Cadherin 3.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					TCTTGAGCCTGAACATCAATC	0.333000													5	61					0.014758	0.016014	1	1	0
CD81-AS1	101927682	broad.mit.edu	37	11	2356806	2356806	+	RNA	SNP	A	A	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr11:2356806A>C	ENST00000413483.1	-	0	407				RPL26P30_ENST00000602923.1_RNA																							AGTGTCCTCGAACTACCTGGA	0.537000													19	152					0	0	1	0	0
PACRGL	133015	broad.mit.edu	37	4	20714530	20714530	+	Silent	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr4:20714530G>T	ENST00000360916.5	+	6	877	c.486G>T	c.(484-486)gtG>gtT	p.V162V	PACRGL_ENST00000444671.2_Intron|PACRGL_ENST00000507634.1_Silent_p.V162V|PACRGL_ENST00000503585.1_Silent_p.V162V|PACRGL_ENST00000513459.1_Silent_p.V109V|PACRGL_ENST00000502938.1_Intron|PACRGL_ENST00000502374.1_Silent_p.V109V|PACRGL_ENST00000538990.1_Intron|PACRGL_ENST00000295290.8_Silent_p.V162V	NM_145048.3	NP_659485.1	Q8N7B6	PACRL_HUMAN	PARK2 co-regulated-like	162							binding			endometrium(2)|lung(7)|prostate(1)	10						TGATTCCTGTGCTAAAGGCAG	0.333000													12	151					5.16669e-11	8.44554e-11	1	1	0
SRPX	8406	broad.mit.edu	37	X	38024095	38024095	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chrX:38024095G>T	ENST00000378533.3	-	5	686	c.580C>A	c.(580-582)Ccc>Acc	p.P194T	SRPX_ENST00000432886.2_Missense_Mutation_p.P135T|SRPX_ENST00000544439.1_Missense_Mutation_p.P174T|SRPX_ENST00000538295.1_Missense_Mutation_p.P194T|SRPX_ENST00000343800.6_Missense_Mutation_p.P181T|TM4SF2_ENST00000465127.1_Intron	NM_006307.4	NP_006298.1	P78539	SRPX_HUMAN	sushi-repeat containing protein, X-linked	194	HYR.				cell adhesion	cell surface|membrane				autonomic_ganglia(1)|breast(2)|endometrium(5)|large_intestine(5)|lung(10)|prostate(2)	25						AGTTTGTTGGGTTCTGCAATG	0.423000													5	24					0.000602214	0.000717592	1	1	0
FER1L6	654463	broad.mit.edu	37	8	125131932	125131932	+	Silent	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr8:125131932C>A	ENST00000522917.1	+	41	5681	c.5475C>A	c.(5473-5475)atC>atA	p.I1825I	FER1L6-AS2_ENST00000520031.1_RNA|FER1L6_ENST00000399018.1_Silent_p.I1825I	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1825						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AAAAGTAcatcatcattgctt	0.483000													32	163					5.77227e-19	1.05138e-18	1	1	0
SPTA1	6708	broad.mit.edu	37	1	158612647	158612647	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr1:158612647G>T	ENST00000368148.3	-	32	4742	c.4562C>A	c.(4561-4563)cCc>cAc	p.P1521H	SPTA1_ENST00000368147.3_Missense_Mutation_p.P1521H	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1521					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					ACAGGCTGTGGGCAGCATCTC	0.448000													20	135					4.96729e-08	7.32173e-08	1	1	0
ADAMTS8	11095	broad.mit.edu	37	11	130284551	130284551	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr11:130284551C>T	ENST00000257359.6	-	5	2147	c.1441G>A	c.(1441-1443)Ggg>Agg	p.G481R		NM_007037.4	NP_008968.4	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 8	481	Disintegrin.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		GGCTCAGCCCCATCAGTGTGG	0.657000													10	102					0	0	1	0	0
CLEC1B	51266	broad.mit.edu	37	12	10150970	10150970	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr12:10150970G>T	ENST00000298527.6	-	2	253	c.74C>A	c.(73-75)gCa>gAa	p.A25E	CLEC1B_ENST00000428126.2_Intron|CLEC1B_ENST00000348658.4_Intron	NM_016509.3	NP_057593.3	Q9P126	CLC1B_HUMAN	C-type lectin domain family 1, member B	25					cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	protein binding|sugar binding|transmembrane receptor activity			NS(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(12)|stomach(1)|urinary_tract(1)	19						GGAGGAGGATGCAGAGCCAAC	0.557000													16	113					1.3612e-06	1.91772e-06	1	1	0
ZFPM2	23414	broad.mit.edu	37	8	106815450	106815450	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr8:106815450G>T	ENST00000407775.2	+	8	3390	c.3140G>T	c.(3139-3141)gGa>gTa	p.G1047V	ZFPM2_ENST00000378472.4_Missense_Mutation_p.G778V|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.G915V|ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000520492.1_Missense_Mutation_p.G915V|RP11-152P17.2_ENST00000509144.2_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	1047					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GTGAATGGTGGACTGAAACAA	0.488000													11	45					2.27111e-07	3.30933e-07	1	1	0
OR8J3	81168	broad.mit.edu	37	11	55905081	55905081	+	Silent	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr11:55905081G>T	ENST00000301529.1	-	1	113	c.114C>A	c.(112-114)acC>acA	p.T38T		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	38					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					TCCCTGCCATGGTCAGCACAT	0.488000													21	148					1.2644e-06	1.79124e-06	1	1	0
TFRC	7037	broad.mit.edu	37	3	195798920	195798920	+	Missense_Mutation	SNP	T	T	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr3:195798920T>C	ENST00000360110.4	-	5	707	c.538A>G	c.(538-540)Aaa>Gaa	p.K180E	TFRC_ENST00000540528.1_3'UTR|TFRC_ENST00000535031.1_5'UTR|TFRC_ENST00000392396.3_Missense_Mutation_p.K180E|TFRC_ENST00000420415.1_Missense_Mutation_p.K99E	NM_001128148.1	NP_001121620.1	P02786	TFR1_HUMAN	transferrin receptor	180					cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)		CGCCAGACTTTGCTGAGTTTA	0.348000			T	BCL6	NHL								15	60					0	0	1	0	0
TMEM246	84302	broad.mit.edu	37	9	104238995	104238995	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr9:104238995C>T	ENST00000374851.1	-	4	1527	c.380G>A	c.(379-381)cGg>cAg	p.R127Q	RP11-490D19.6_ENST00000425734.1_RNA|TMEM246_ENST00000374848.3_Missense_Mutation_p.R127Q|RP11-490D19.6_ENST00000431507.1_RNA|RP11-490D19.6_ENST00000424154.1_RNA|TMEM246_ENST00000374847.1_Missense_Mutation_p.R127Q|RP11-490D19.6_ENST00000450109.1_RNA			Q9BRR3	CI125_HUMAN	transmembrane protein 246	127						integral to membrane											CTGAAGAAGCCGGTGGAACTG	0.602000													10	84					0	0	1	0	0
ITM2A	9452	broad.mit.edu	37	X	78618173	78618173	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chrX:78618173G>T	ENST00000434584.2	-	3	661	c.325C>A	c.(325-327)Ctg>Atg	p.L109M	ITM2A_ENST00000373298.2_Missense_Mutation_p.L153M|ITM2A_ENST00000469541.1_5'UTR	NM_001171581.1	NP_001165052.1	O43736	ITM2A_HUMAN	integral membrane protein 2A	153						integral to membrane	protein binding			breast(1)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	18						AACAAGTCCAGGTAAGCAGTC	0.438000													4	17					0.184627	0.186825	1	1	0
KCNN2	3781	broad.mit.edu	37	5	113831649	113831649	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr5:113831649G>T	ENST00000512097.3	+	9	2528	c.1510G>T	c.(1510-1512)Gag>Tag	p.E504*	KCNN2_ENST00000264773.3_Nonsense_Mutation_p.E504*|RP11-492A10.1_ENST00000514115.1_RNA|KCNN2_ENST00000503706.1_Nonsense_Mutation_p.E156*			Q9H2S1	KCNN2_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	504						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		TGAAGACTTCGAGAAGAGGAT	0.443000													10	153					1.76689e-08	2.65034e-08	1	1	0
ATP2B4	493	broad.mit.edu	37	1	203669983	203669983	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr1:203669983C>T	ENST00000357681.5	+	6	1956	c.833C>T	c.(832-834)tCt>tTt	p.S278F	ATP2B4_ENST00000341360.2_Missense_Mutation_p.S278F|ATP2B4_ENST00000367218.3_Missense_Mutation_p.S278F|ATP2B4_ENST00000367219.3_Missense_Mutation_p.S278F|ATP2B4_ENST00000391954.2_Missense_Mutation_p.S278F	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	278					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			GGTGTCAACTCTCAGACTGGA	0.483000													9	48					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577556	7577556	+	Missense_Mutation	SNP	C	C	A	rs121912655		TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr17:7577556C>A	ENST00000420246.2	-	7	857	c.725G>T	c.(724-726)tGc>tTc	p.C242F	TP53_ENST00000413465.2_Missense_Mutation_p.C242F|TP53_ENST00000359597.4_Missense_Mutation_p.C242F|TP53_ENST00000269305.4_Missense_Mutation_p.C242F|TP53_ENST00000445888.2_Missense_Mutation_p.C242F|TP53_ENST00000455263.2_Missense_Mutation_p.C242F	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	242	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		C -> F (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C242F(82)|p.C242Y(44)|p.C242S(16)|p.0?(8)|p.C149F(6)|p.?(5)|p.N239_C242delNSSC(3)|p.C149Y(2)|p.C238fs*21(1)|p.C242fs*20(1)|p.Y236_M243delYMCNSSCM(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.C242_M246>L(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.H233_C242del10(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCGCCCATGCAGGAACTGTT	0.577000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			5	66					0.000602214	0.000717592	1	1	0
ZNF521	25925	broad.mit.edu	37	18	22805951	22805951	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr18:22805951G>T	ENST00000361524.3	-	4	2079	c.1931C>A	c.(1930-1932)aCa>aAa	p.T644K	ZNF521_ENST00000538137.2_Missense_Mutation_p.T644K|ZNF521_ENST00000584787.1_Missense_Mutation_p.T424K	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	644					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GTCTAGGGATGTGTACTTAGC	0.463000			T	PAX5	ALL								13	192					4.36969e-10	7.00799e-10	1	1	0
YEATS2	55689	broad.mit.edu	37	3	183472056	183472056	+	Silent	SNP	A	A	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr3:183472056A>T	ENST00000305135.5	+	11	1488	c.1293A>T	c.(1291-1293)gcA>gcT	p.A431A		NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	431					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			AGCCAATAGCATCAAGCTGCA	0.443000													28	139					0	0	1	0	0
CDC25C	995	broad.mit.edu	37	5	137621514	137621514	+	Missense_Mutation	SNP	T	T	G			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr5:137621514T>G	ENST00000323760.6	-	14	1567	c.1289A>C	c.(1288-1290)cAg>cCg	p.Q430P	CDC25C_ENST00000357274.3_Missense_Mutation_p.Q387P|CDC25C_ENST00000356505.3_Missense_Mutation_p.Q400P|CDC25C_ENST00000348983.3_Missense_Mutation_p.Q357P|CDC25C_ENST00000415130.2_Missense_Mutation_p.Q357P|CDC25C_ENST00000513970.1_Missense_Mutation_p.Q430P|CDC25C_ENST00000514555.1_Missense_Mutation_p.Q400P	NM_001790.3	NP_001781.2	P30307	MPIP3_HUMAN	cell division cycle 25C	430					cell cycle checkpoint|cell division|cell proliferation|DNA replication|G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm	protein tyrosine phosphatase activity|WW domain binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(5)|skin(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			GCAGTAGCTCTGTGGTTCACA	0.522000													5	74					0	0	1	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29974804	29974804	+	RNA	SNP	A	A	G			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr6:29974804A>G	ENST00000376797.3	-	0	1346				ZNRD1-AS1_ENST00000448093.1_RNA|HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA																							TGACCGAGTGAACCTGCGGAC	0.672000													3	17					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209790914	209790914	+	Silent	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr1:209790914C>A	ENST00000391911.1	-	20	3458	c.3069G>T	c.(3067-3069)cgG>cgT	p.R1023R	LAMB3_ENST00000356082.4_Silent_p.R1023R|LAMB3_ENST00000367030.3_Silent_p.R1023R	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	1023	Domain I.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		TTTCTGCTGGCCGCAGTACCT	0.577000													7	45					8.12818e-05	0.000101602	1	1	0
TRPC6	7225	broad.mit.edu	37	11	101375089	101375089	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr11:101375089T>A	ENST00000344327.3	-	2	1035	c.611A>T	c.(610-612)gAt>gTt	p.D204V	TRPC6_ENST00000532133.1_Missense_Mutation_p.D204V|TRPC6_ENST00000348423.4_Missense_Mutation_p.D204V|TRPC6_ENST00000360497.4_Missense_Mutation_p.D204V	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	204					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		ATAAAAATCATCTTGCTGGAG	0.468000													10	92					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17228505	17228505	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr16:17228505C>A	ENST00000261381.6	-	9	1936	c.1852G>T	c.(1852-1854)Ggg>Tgg	p.G618W	CTD-2576D5.4_ENST00000567344.1_RNA	NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	618					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GGGTAGTTCCCGTACAGGTAA	0.572000													14	150					4.36969e-10	7.00799e-10	1	1	0
STK38L	23012	broad.mit.edu	37	12	27462089	27462089	+	Missense_Mutation	SNP	A	A	G			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr12:27462089A>G	ENST00000389032.3	+	5	521	c.352A>G	c.(352-354)Atg>Gtg	p.M118V	STK38L_ENST00000539577.1_Missense_Mutation_p.M25V	NM_015000.3	NP_055815.1	Q9Y2H1	ST38L_HUMAN	serine/threonine kinase 38 like	118	Protein kinase.				intracellular protein kinase cascade|regulation of cellular component organization	actin cytoskeleton|cytoplasm	actin binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)	12	Colorectal(261;0.0847)					TATCTATGCAATGAAGATATT	0.343000													8	73					0	0	1	0	0
UGT2B11	10720	broad.mit.edu	37	4	70066359	70066359	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr4:70066359C>A	ENST00000446444.1	-	6	1397	c.1389G>T	c.(1387-1389)tgG>tgT	p.W463C	RP11-704M14.1_ENST00000504301.1_RNA|RP11-704M14.1_ENST00000505646.1_RNA	NM_001073.1	NP_001064.1	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B11	463					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	42						CAAATTCAATCCAGAAGACTG	0.413000													19	149					1.33834e-09	2.09372e-09	1	1	0
GPR133	283383	broad.mit.edu	37	12	131498759	131498759	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr12:131498759G>T	ENST00000261654.5	+	13	1906	c.1347G>T	c.(1345-1347)atG>atT	p.M449I	GPR133_ENST00000376682.4_Missense_Mutation_p.M135I|GPR133_ENST00000535015.1_Missense_Mutation_p.M481I	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	449					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		CGGAGGCCATGCATCACCAGG	0.592000													8	69					0.27861	0.27861	1	1	0
BTN2A3P	54718	broad.mit.edu	37	6	26431620	26431620	+	RNA	SNP	G	G	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr6:26431620G>A	ENST00000466808.2	+	0	1568																											GGCCATCTCAGCAGCCACTGC	0.582000													9	81					0	0	1	0	0
LRRTM4	80059	broad.mit.edu	37	2	76975898	76975898	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr2:76975898C>A	ENST00000409911.1	-	3	1922	c.1699G>T	c.(1699-1701)Ggc>Tgc	p.G567C	LRRTM4_ENST00000409093.1_Missense_Mutation_p.G566C|LRRTM4_ENST00000409884.1_Missense_Mutation_p.G566C	NM_001134745.1	NP_001128217.1	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	566						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(6)|lung(49)|ovary(2)|pancreas(3)|prostate(1)|upper_aerodigestive_tract(1)	64				Colorectal(11;0.059)		TGGTCTCGGCCCAGCTCCAGG	0.607000													10	96					4.68919e-08	6.99265e-08	1	1	0
OBSCN	84033	broad.mit.edu	37	1	228474602	228474602	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr1:228474602C>G	ENST00000570156.2	+	40	10767	c.10693C>G	c.(10693-10695)Cgg>Ggg	p.R3565G	OBSCN_ENST00000366709.4_Missense_Mutation_p.R255G|OBSCN_ENST00000422127.1_Missense_Mutation_p.R3136G|OBSCN_ENST00000366707.4_Missense_Mutation_p.R255G|OBSCN_ENST00000284548.11_Missense_Mutation_p.R3136G|OBSCN_ENST00000359599.6_Missense_Mutation_p.R1983G	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2598	Ig-like 36.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GAAGACCCTGCGGGGGTCTGC	0.642000													6	21					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24537546	24537546	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr5:24537546C>A	ENST00000264463.4	-	3	976	c.469G>T	c.(469-471)Gag>Tag	p.E157*		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	157	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		AACGTTGGCTCATTGTCATTG	0.388000										HNSCC(23;0.051)			13	190					0.0167234	0.0180698	1	1	0
MGA	23269	broad.mit.edu	37	15	42042523	42042523	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr15:42042523G>T	ENST00000219905.7	+	17	6899	c.6718G>T	c.(6718-6720)Gaa>Taa	p.E2240*	MGA_ENST00000570161.1_Nonsense_Mutation_p.E2240*|MGA_ENST00000545763.1_Nonsense_Mutation_p.E2031*|MGA_ENST00000389936.4_Nonsense_Mutation_p.E2201*|MGA_ENST00000566586.1_Nonsense_Mutation_p.E2031*	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	2201						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TTTGAAAACTGAATGTGATTC	0.413000													12	68					0.000978159	0.00115477	1	1	0
SLCO5A1	81796	broad.mit.edu	37	8	70744698	70744698	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr8:70744698C>A	ENST00000260126.3	-	2	917	c.211G>T	c.(211-213)Gag>Tag	p.E71*	SLCO5A1_ENST00000524945.1_Nonsense_Mutation_p.E71*|SLCO5A1_ENST00000528658.1_5'UTR|SLCO5A1_ENST00000530307.1_Nonsense_Mutation_p.E71*	NM_030958.2	NP_112220.2	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family, member 5A1	71						integral to membrane|plasma membrane	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	53	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			TGCTTCAACTCCTGGTGGCCC	0.647000											OREG0018815	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	50					1.52009e-12	2.55015e-12	1	1	0
DICER1	23405	broad.mit.edu	37	14	95562559	95562559	+	Silent	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr14:95562559C>A	ENST00000526495.1	-	25	4989	c.4698G>T	c.(4696-4698)ctG>ctT	p.L1566L	DICER1_ENST00000393063.1_Silent_p.L1566L|DICER1_ENST00000556045.1_Silent_p.L464L|DICER1_ENST00000527414.1_Silent_p.L1566L|DICER1_ENST00000343455.3_Silent_p.L1566L|DICER1_ENST00000541352.1_Silent_p.L1566L			Q9UPY3	DICER_HUMAN	dicer 1, ribonuclease type III	1566					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		AGCAGCCCAGCAGGGCTTCCA	0.517000			"""Mis F, N"""		"""sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"""	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome				12	142					0.000978159	0.00115477	1	1	0
KCNC2	3747	broad.mit.edu	37	12	75444636	75444636	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr12:75444636C>A	ENST00000549446.1	-	3	1829	c.1149G>T	c.(1147-1149)ttG>ttT	p.L383F	KCNC2_ENST00000540018.1_Missense_Mutation_p.L383F|KCNC2_ENST00000350228.2_Missense_Mutation_p.L383F|KCNC2_ENST00000548513.1_Missense_Mutation_p.L383F|KCNC2_ENST00000548243.1_5'UTR|KCNC2_ENST00000393288.2_Missense_Mutation_p.L383F|KCNC2_ENST00000341669.3_Missense_Mutation_p.L383F|KCNC2_ENST00000550433.1_Missense_Mutation_p.L383F|KCNC2_ENST00000298972.1_Missense_Mutation_p.L383F	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	383					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						TTATCAGCAGCAAAAATTCAT	0.443000													9	64					0.000274275	0.000336251	1	1	0
DLG5	9231	broad.mit.edu	37	10	79571788	79571788	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr10:79571788T>A	ENST00000372391.2	-	22	4221	c.4216A>T	c.(4216-4218)Acg>Tcg	p.T1406S	DLG5_ENST00000459739.1_5'UTR|DLG5_ENST00000372388.2_Missense_Mutation_p.T1066S	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	1406	PDZ 3.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			TGCTGCTCCGTGGCGCTCCGC	0.657000													6	63					0	0	1	0	0
PSG2	5670	broad.mit.edu	37	19	43585207	43585207	+	Missense_Mutation	SNP	C	C	A	rs146247259	byFrequency	TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr19:43585207C>A	ENST00000406487.1	-	2	354	c.256G>T	c.(256-258)Ggt>Tgt	p.G86C		NM_031246.3	NP_112536.2	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	86	Ig-like V-type.				cell migration|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(24)|ovary(1)|pancreas(2)|prostate(6)|stomach(2)|urinary_tract(2)	49		Prostate(69;0.00682)				ATTATTTGACCGTCTACTACA	0.448000													38	289					3.54561e-26	6.50453e-26	1	1	0
TANC1	85461	broad.mit.edu	37	2	160035493	160035493	+	Missense_Mutation	SNP	A	A	G			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr2:160035493A>G	ENST00000263635.6	+	14	2566	c.2329A>G	c.(2329-2331)Att>Gtt	p.I777V	TANC1_ENST00000454300.1_Missense_Mutation_p.I671V	NM_001145909.1|NM_033394.2	NP_001139381.1|NP_203752.2	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	777						cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						CTTTCAGGCTATTAATGCTGG	0.562000													22	204					0	0	1	0	0
SCLY	51540	broad.mit.edu	37	2	238978020	238978020	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr2:238978020G>T	ENST00000254663.6	+	4	552	c.410G>T	c.(409-411)aGc>aTc	p.S137I	SCLY_ENST00000555827.1_Missense_Mutation_p.S129I|SCLY_ENST00000373332.3_Missense_Mutation_p.Q25H|SCLY_ENST00000429612.2_Intron|SCLY_ENST00000422984.2_Intron|SCLY_ENST00000409736.2_Missense_Mutation_p.S129I|SCLY_ENST00000480859.1_3'UTR	NM_016510.5	NP_057594.4	Q96I15	SCLY_HUMAN	selenocysteine lyase	129					cellular amino acid metabolic process	cytosol	pyridoxal phosphate binding|selenocysteine lyase activity|transferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(6)|lung(5)|ovary(2)|prostate(2)|stomach(1)|urinary_tract(1)	22		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;1.37e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.6e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;8.25e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000128)|Lung(119;0.0118)|LUSC - Lung squamous cell carcinoma(224;0.0285)		GGGCACCACAGCCCAGTGAAG	0.522000													6	48					0.00116845	0.00135433	1	1	0
DCHS2	54798	broad.mit.edu	37	4	155287387	155287387	+	Silent	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr4:155287387G>T	ENST00000357232.3	-	5	668	c.669C>A	c.(667-669)tcC>tcA	p.S223S	DCHS2_ENST00000339452.1_Silent_p.S817S	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	223	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TGGTAAAAAGGGACGACACGT	0.448000													4	60					0.00024832	0.000307386	1	1	0
MUC16	94025	broad.mit.edu	37	19	9074569	9074569	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr19:9074569A>T	ENST00000397910.4	-	3	13080	c.12877T>A	c.(12877-12879)Tcc>Acc	p.S4293T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4295	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCTCGGAGGAGCCAAATACT	0.522000													5	54					0	0	1	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72090866	72090866	+	Silent	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr14:72090866G>T	ENST00000555818.1	+	4	2079	c.1731G>T	c.(1729-1731)gtG>gtT	p.V577V	SIPA1L1_ENST00000537413.1_Silent_p.V52V|SIPA1L1_ENST00000358550.2_Silent_p.V577V|SIPA1L1_ENST00000381232.3_Silent_p.V577V	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	577					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		TGGAGCACGTGGTTCCTGAGC	0.562000													24	154					2.41591e-17	4.27818e-17	1	1	0
ACCSL	390110	broad.mit.edu	37	11	44080221	44080221	+	Silent	SNP	T	T	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr11:44080221T>C	ENST00000378832.1	+	13	1652	c.1596T>C	c.(1594-1596)ttT>ttC	p.F532F		NM_001031854.2	NP_001027025.2	Q4AC99	1A1L2_HUMAN	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like	532							1-aminocyclopropane-1-carboxylate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(14)|ovary(5)|pancreas(1)|skin(2)	34						GCCTCATCTTTGCAGATGAGC	0.502000													7	61					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	121882328	121882328	+	Silent	SNP	T	T	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr12:121882328T>A	ENST00000377069.4	-	15	2428	c.2022A>T	c.(2020-2022)tcA>tcT	p.S674S	KDM2B_ENST00000542973.1_Silent_p.S73S|KDM2B_ENST00000536437.1_Intron|KDM2B_ENST00000377071.4_Silent_p.S705S	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	705					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						CCACACCCTCTGACTCCTTAA	0.607000													8	60					0	0	1	0	0
OR4K5	79317	broad.mit.edu	37	14	20388985	20388985	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr14:20388985G>T	ENST00000315915.4	+	1	245	c.220G>T	c.(220-222)Gct>Tct	p.A74S		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	74					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CATTTGTCAGGCTTCTTTTGC	0.418000													23	381					3.01185e-09	4.65467e-09	1	1	0
OR10J1	26476	broad.mit.edu	37	1	159410064	159410064	+	Silent	SNP	A	A	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr1:159410064A>T	ENST00000423932.3	+	1	553	c.516A>T	c.(514-516)acA>acT	p.T172T	RP11-550P17.5_ENST00000431862.1_RNA	NM_012351.2	NP_036483.2	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J, member 1	172					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					CGCAAGTGACATCTGTATTCA	0.498000													31	182					0	0	1	0	0
SNX2	6643	broad.mit.edu	37	5	122163095	122163095	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr5:122163095G>T	ENST00000379516.2	+	13	1486	c.1378G>T	c.(1378-1380)Ggg>Tgg	p.G460W	SNX2_ENST00000514949.1_Missense_Mutation_p.G343W|SNX2_ENST00000510372.1_3'UTR	NM_003100.2	NP_003091.2	O60749	SNX2_HUMAN	sorting nexin 2	460					cell communication|endocytosis|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding|protein transporter activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(2)|prostate(1)|skin(1)	19		all_cancers(142;1.14e-44)|all_lung(232;1.03e-13)|Lung NSC(810;2.5e-13)|Breast(839;0.000812)|Myeloproliferative disorder(839;0.0122)|Prostate(80;0.0235)|all_hematologic(541;0.0592)|all_neural(839;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	all cancers(49;2.13e-24)|Epithelial(69;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(64;5.6e-11)|BRCA - Breast invasive adenocarcinoma(61;0.00013)|GBM - Glioblastoma multiforme(465;0.000357)|COAD - Colon adenocarcinoma(49;0.000887)|Lung(113;0.0109)		AGTGCAACAAGGGGAAAGAGA	0.313000													5	84					3.59834e-05	4.58788e-05	1	1	0
TAS2R40	259286	broad.mit.edu	37	7	142920023	142920023	+	Silent	SNP	C	C	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr7:142920023C>T	ENST00000408947.3	+	1	894	c.852C>T	c.(850-852)atC>atT	p.I284I		NM_176882.1	NP_795363.1	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	284					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	8	Melanoma(164;0.059)					GCAAGATCATCATGGCTGCCT	0.468000													7	148					0	0	1	0	0
LRRTM2	26045	broad.mit.edu	37	5	138209593	138209593	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr5:138209593C>G	ENST00000274711.6	-	2	1035	c.657G>C	c.(655-657)aaG>aaC	p.K219N	CTNNA1_ENST00000520400.1_Intron|CTNNA1_ENST00000518825.1_Intron|LRRTM2_ENST00000521094.2_Intron|LRRTM2_ENST00000518785.1_3'UTR|CTNNA1_ENST00000355078.5_Intron|CTNNA1_ENST00000302763.7_Intron	NM_015564.2	NP_056379.1	O43300	LRRT2_HUMAN	leucine rich repeat transmembrane neuronal 2	219						cell junction|integral to membrane|postsynaptic membrane				NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(1)|urinary_tract(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			CAAAATTAATCTTCGTCAGCT	0.448000													35	311					0	0	1	0	0
C1orf74	148304	broad.mit.edu	37	1	209956756	209956756	+	Missense_Mutation	SNP	C	C	A	rs140853587		TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr1:209956756C>A	ENST00000294811.1	-	2	480	c.224G>T	c.(223-225)gGg>gTg	p.G75V		NM_152485.2	NP_689698.1	Q96LT6	CA074_HUMAN	chromosome 1 open reading frame 74	75										endometrium(2)|large_intestine(3)|lung(8)|prostate(1)|skin(1)	15				OV - Ovarian serous cystadenocarcinoma(81;0.0328)		GAAGCCAAGCCCCTTCAGCTC	0.547000													9	54					1.12685e-05	1.50443e-05	1	1	0
FAM154B	283726	broad.mit.edu	37	15	82574554	82574554	+	Silent	SNP	A	A	T	rs141621278	byFrequency	TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr15:82574554A>T	ENST00000339465.5	+	3	417	c.348A>T	c.(346-348)acA>acT	p.T116T	FAM154B_ENST00000565501.1_3'UTR|FAM154B_ENST00000427381.2_Silent_p.T101T	NM_001008226.1	NP_001008227.1	Q658L1	F154B_HUMAN	family with sequence similarity 154, member B	116										autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(2)	19						ATTCAACTACATTTCAGGATG	0.393000													22	134					0	0	1	0	0
RILP	83547	broad.mit.edu	37	17	1549867	1549867	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr17:1549867T>A	ENST00000301336.6	-	8	1347	c.1075A>T	c.(1075-1077)Acc>Tcc	p.T359S		NM_031430.2	NP_113618.2	Q96NA2	RILP_HUMAN	Rab interacting lysosomal protein	359					endosome to lysosome transport|protein transport	late endosome membrane|lysosomal membrane|phagocytic vesicle membrane	Rab GTPase binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(4)	15				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GGGCTGCTGGTCTCATCCTCA	0.582000													13	133					0	0	1	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130222714	130222714	+	Silent	SNP	C	C	G			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chrX:130222714C>G	ENST00000276211.5	+	12	1944	c.1599C>G	c.(1597-1599)ccC>ccG	p.P533P	ARHGAP36_ENST00000370922.1_Silent_p.P521P|ARHGAP36_ENST00000370921.1_Silent_p.P397P	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	533					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						TCCGTGTGCCCCGGGAGAAGG	0.577000													6	27					0	0	1	0	0
SLC4A7	9497	broad.mit.edu	37	3	27460108	27460108	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr3:27460108C>A	ENST00000295736.5	-	11	1571	c.1501G>T	c.(1501-1503)Gct>Tct	p.A501S	SLC4A7_ENST00000454389.1_Missense_Mutation_p.A510S|SLC4A7_ENST00000428386.1_Missense_Mutation_p.A377S|SLC4A7_ENST00000435667.2_Missense_Mutation_p.A386S|SLC4A7_ENST00000388777.4_Missense_Mutation_p.A51S|SLC4A7_ENST00000437179.1_Missense_Mutation_p.A382S|SLC4A7_ENST00000445684.1_Missense_Mutation_p.A497S|SLC4A7_ENST00000440156.1_Missense_Mutation_p.A497S|SLC4A7_ENST00000446700.1_Missense_Mutation_p.A493S|SLC4A7_ENST00000425128.2_Missense_Mutation_p.A493S|SLC4A7_ENST00000455077.1_Missense_Mutation_p.A382S	NM_003615.4	NP_003606.3	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 7	501						apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(9)|ovary(4)|skin(1)	38						GCTTTATAAGCTACATCATGG	0.308000													3	23					0.115264	0.119481	1	1	0
TMEM176A	55365	broad.mit.edu	37	7	150501929	150501929	+	Silent	SNP	G	G	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr7:150501929G>A	ENST00000484928.1	+	7	1262	c.681G>A	c.(679-681)aaG>aaA	p.K227K	TMEM176A_ENST00000461345.1_Silent_p.K168K|TMEM176A_ENST00000004103.3_Silent_p.K227K			Q96HP8	T176A_HUMAN	transmembrane protein 176A	227						integral to membrane				breast(1)|endometrium(1)|lung(7)|ovary(2)|stomach(1)	12			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GAGACCAGAAGGAAATGTTGG	0.522000													10	91					0	0	1	0	0
GLRA3	8001	broad.mit.edu	37	4	175688114	175688114	+	Splice_Site	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr4:175688114C>A	ENST00000274093.3	-	3	769	c.267_splice	c.e3+1	p.M89_splice	GLRA3_ENST00000340217.5_Splice_Site_p.M89_splice	NM_006529.2	NP_006520.2	O75311	GLRA3_HUMAN	glycine receptor, alpha 3	89					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			endometrium(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	35		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	AAATGCCTACCATGGTCGTCT	0.353000													9	108					0.00621372	0.00688912	1	1	0
F3	2152	broad.mit.edu	37	1	95001593	95001593	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr1:95001593T>A	ENST00000334047.7	-	3	503	c.340A>T	c.(340-342)Aat>Tat	p.N114Y	F3_ENST00000480356.1_5'UTR|F3_ENST00000370207.4_Missense_Mutation_p.N114Y	NM_001993.4	NP_001984.1	P13726	TF_HUMAN	coagulation factor III (thromboplastin, tissue factor)	114					activation of caspase activity|activation of plasma proteins involved in acute inflammatory response|anti-apoptosis|blood coagulation, extrinsic pathway|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of protein kinase B signaling cascade	extracellular matrix|extracellular space|integral to membrane	cell surface binding|phospholipid binding|protease binding			NS(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(7)	14		all_lung(203;0.00106)|Lung NSC(277;0.00475)		all cancers(265;0.0232)|Epithelial(280;0.121)	Coagulation factor VIIa(DB00036)	CTCTCCACATTCCCTGCAGGG	0.527000													14	161					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25327736	25327736	+	RNA	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr15:25327736G>T	ENST00000546682.1	+	0	72				SNHG14_ENST00000549804.2_RNA	NR_003361.1																						TACTTCCTAGGTGGTGTGGGC	0.537000													3	16					0.004672	0.00522526	1	1	0
LRRTM4	80059	broad.mit.edu	37	2	76975914	76975914	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr2:76975914G>C	ENST00000409911.1	-	3	1906	c.1683C>G	c.(1681-1683)agC>agG	p.S561R	LRRTM4_ENST00000409093.1_Missense_Mutation_p.S560R|LRRTM4_ENST00000409884.1_Missense_Mutation_p.S560R	NM_001134745.1	NP_001128217.1	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	560						integral to membrane		p.S560S(1)		autonomic_ganglia(1)|endometrium(1)|large_intestine(6)|lung(49)|ovary(2)|pancreas(3)|prostate(1)|upper_aerodigestive_tract(1)	64				Colorectal(11;0.059)		CCAGGCCGGGGCTTTCGTCCT	0.587000													12	89					0	0	1	0	0
SMC2	10592	broad.mit.edu	37	9	106877090	106877090	+	Missense_Mutation	SNP	A	A	G			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr9:106877090A>G	ENST00000286398.7	+	13	1939	c.1651A>G	c.(1651-1653)Aat>Gat	p.N551D	SMC2_ENST00000374787.3_Missense_Mutation_p.N551D|SMC2_ENST00000374793.3_Missense_Mutation_p.N551D|SMC2_ENST00000303219.8_Missense_Mutation_p.N551D	NM_001042551.1|NM_001265602.1|NM_006444.2	NP_001036016.1|NP_001252531.1|NP_006435.2	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	551	Flexible hinge.				cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(14)|ovary(5)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	48						ACGACTCTACAATGTTGTAGT	0.328000													5	67					0	0	1	0	0
ZNF521	25925	broad.mit.edu	37	18	22805950	22805950	+	Silent	SNP	T	T	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr18:22805950T>A	ENST00000361524.3	-	4	2080	c.1932A>T	c.(1930-1932)acA>acT	p.T644T	ZNF521_ENST00000538137.2_Silent_p.T644T|ZNF521_ENST00000584787.1_Silent_p.T424T	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	644					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TGTCTAGGGATGTGTACTTAG	0.458000			T	PAX5	ALL								13	193					0	0	1	0	0
HHIPL2	79802	broad.mit.edu	37	1	222713400	222713400	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr1:222713400C>T	ENST00000343410.6	-	4	1460	c.1402G>A	c.(1402-1404)Gaa>Aaa	p.E468K		NM_024746.3	NP_079022.2	Q6UWX4	HIPL2_HUMAN	HHIP-like 2	468					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(7)|lung(28)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59				GBM - Glioblastoma multiforme(131;0.0185)		GCAAACCCTTCCTTTGCTCTC	0.488000													10	117					0	0	1	0	0
ZNF780B	163131	broad.mit.edu	37	19	40540449	40540449	+	Missense_Mutation	SNP	T	T	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr19:40540449T>C	ENST00000434248.1	-	5	2382	c.2317A>G	c.(2317-2319)Agt>Ggt	p.S773G	ZNF780B_ENST00000221355.6_Missense_Mutation_p.S625G	NM_001005851.2	NP_001005851.1	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	773					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					GTATGAATACTCTGAGGTTGA	0.423000													14	91					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55924820	55924820	+	Silent	SNP	T	T	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr6:55924820T>C	ENST00000244728.5	-	28	3001	c.2604A>G	c.(2602-2604)ttA>ttG	p.L868L	COL21A1_ENST00000535941.1_Silent_p.L868L|COL21A1_ENST00000370808.2_Silent_p.L234L|COL21A1_ENST00000370819.1_Silent_p.L865L|COL21A1_ENST00000467045.1_5'UTR	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	868	Collagen-like 6.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			GCATACCTTTTAATCCTCTGA	0.398000													16	86					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55970819	55970819	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr4:55970819T>A	ENST00000263923.4	-	13	2273	c.1978A>T	c.(1978-1980)Aca>Tca	p.T660S		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	660	Ig-like C2-type 6.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CCTAGGACTGTGAGCTGCCTG	0.473000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			6	24					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33328573	33328573	+	Silent	SNP	G	G	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr20:33328573G>A	ENST00000374796.2	-	12	8057	c.5487C>T	c.(5485-5487)acC>acT	p.T1829T	NCOA6_ENST00000359003.2_Silent_p.T1829T			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1829	EP300/CRSP3-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						TACATGCCTTGGTCAACAAAA	0.493000													23	163					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126372247	126372247	+	Missense_Mutation	SNP	G	G	T	rs34531924		TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr4:126372247G>T	ENST00000394329.3	+	9	10089	c.10076G>T	c.(10075-10077)gGa>gTa	p.G3359V	FAT4_ENST00000335110.5_Missense_Mutation_p.G1657V	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3359	Cadherin 32.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TATGTTTCTGGAATTCTTGAT	0.393000													21	169					8.04996e-18	1.43548e-17	1	1	0
OR5B21	219968	broad.mit.edu	37	11	58274771	58274771	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr11:58274771T>A	ENST00000360374.2	-	1	807	c.808A>T	c.(808-810)Ata>Tta	p.I270L		NM_001005218.1	NP_001005218.1	A6NL26	OR5BL_HUMAN	olfactory receptor, family 5, subfamily B, member 21	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				ACAGAGGCTATTTTGTCTGTG	0.448000													7	125					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185800932	185800932	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr2:185800932G>T	ENST00000302277.6	+	4	1403	c.809G>T	c.(808-810)aGt>aTt	p.S270I		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	270						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						GTGCTTTTGAGTTCTGAGGAG	0.393000													15	104					4.7546e-09	7.30376e-09	1	1	0
PER3	8863	broad.mit.edu	37	1	7879479	7879479	+	Splice_Site	SNP	A	A	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr1:7879479A>T	ENST00000377532.3	+	13	1881	c.1658_splice	c.e13+1	p.R553_splice	PER3_ENST00000361923.2_Splice_Site_p.R545_splice|RP3-467L1.4_ENST00000451646.1_RNA			P56645	PER3_HUMAN	period circadian clock 3	545	CSNK1E binding domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	39	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		CAGTGTCATCAGGTATGAGAC	0.438000													17	155					0	0	1	0	0
SLC5A11	115584	broad.mit.edu	37	16	24902277	24902277	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr16:24902277G>T	ENST00000347898.3	+	9	1374	c.752G>T	c.(751-753)gGg>gTg	p.G251V	SLC5A11_ENST00000545376.1_Missense_Mutation_p.G181V|SLC5A11_ENST00000539472.1_Missense_Mutation_p.G187V|SLC5A11_ENST00000449109.2_Intron|SLC5A11_ENST00000567758.1_Missense_Mutation_p.G216V|SLC5A11_ENST00000565769.1_Missense_Mutation_p.G187V|SLC5A11_ENST00000568579.1_Missense_Mutation_p.G181V|SLC5A11_ENST00000569071.1_Intron|SLC5A11_ENST00000424767.2_Missense_Mutation_p.G216V	NM_052944.3	NP_443176.2	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/inositol cotransporter), member 11	251					apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(30)|ovary(2)|prostate(2)|urinary_tract(1)	49				GBM - Glioblastoma multiforme(48;0.0365)		AGCAGCTGCGGGCTGCCCCGG	0.567000													21	166					1.01871e-10	1.6546e-10	1	1	0
CDH6	1004	broad.mit.edu	37	5	31323352	31323352	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr5:31323352G>T	ENST00000265071.2	+	12	2575	c.2310G>T	c.(2308-2310)tgG>tgT	p.W770C		NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	770					adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						TTAGTGACTGGGGACCTCGAT	0.478000													8	95					0.00448238	0.00505755	1	1	0
FRS2	10818	broad.mit.edu	37	12	69968091	69968091	+	Nonsense_Mutation	SNP	C	C	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr12:69968091C>T	ENST00000299293.2	+	10	1393	c.883C>T	c.(883-885)Cga>Tga	p.R295*	FRS2_ENST00000549921.1_Nonsense_Mutation_p.R295*|FRS2_ENST00000397997.2_Nonsense_Mutation_p.R295*|FRS2_ENST00000550389.1_Nonsense_Mutation_p.R295*	NM_001278351.1|NM_006654.3	NP_001265280.1|NP_006645.3	Q8WU20	FRS2_HUMAN	fibroblast growth factor receptor substrate 2	295					activation of MAPKK activity|activation of phospholipase C activity|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|transmembrane receptor protein tyrosine phosphatase signaling pathway	endomembrane system|endosome|integral to plasma membrane|membrane fraction	fibroblast growth factor receptor binding|insulin receptor binding|phosphatase activator activity|transmembrane receptor protein tyrosine kinase adaptor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22	Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.94e-18)|Lung(24;9.68e-05)|OV - Ovarian serous cystadenocarcinoma(12;0.000984)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			CAGTGATGAACGAAGAGATGC	0.443000													6	92					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122002558	122002558	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr3:122002558C>A	ENST00000498619.1	+	7	2225	c.1787C>A	c.(1786-1788)cCa>cAa	p.P596Q	CASR_ENST00000296154.5_Missense_Mutation_p.P586Q|CASR_ENST00000490131.1_Missense_Mutation_p.P586Q	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	586					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	AACAAGTGCCCAGATGACTTC	0.502000													7	75					0.0381472	0.039867	1	1	0
OR2L2	26246	broad.mit.edu	37	1	248201638	248201638	+	Silent	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr1:248201638C>A	ENST00000366479.2	+	1	165	c.69C>A	c.(67-69)ggC>ggA	p.G23G	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CAAGAATTGGCCTTTTCGTAT	0.388000													25	192					3.6726e-16	6.41448e-16	1	1	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29974845	29974845	+	RNA	SNP	G	G	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr6:29974845G>C	ENST00000376797.3	-	0	1346				ZNRD1-AS1_ENST00000448093.1_RNA|HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA																							AGAGCGAGGCGGGTGAGTGAC	0.667000													3	14					0	0	1	0	0
KCNC1	3746	broad.mit.edu	37	11	17793415	17793415	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr11:17793415C>A	ENST00000379472.3	+	2	804	c.774C>A	c.(772-774)ttC>ttA	p.F258L	KCNC1_ENST00000265969.6_Missense_Mutation_p.F258L	NM_004976.4	NP_004967.1	P48547	KCNC1_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 1	258						voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.F258F(2)		breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(7)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						GGTTCACCTTCGAGTTCCTCA	0.547000													11	177					3.03607e-14	5.19596e-14	1	1	0
EEA1	8411	broad.mit.edu	37	12	93210069	93210069	+	Silent	SNP	T	T	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr12:93210069T>C	ENST00000322349.8	-	15	2100	c.1836A>G	c.(1834-1836)gcA>gcG	p.A612A		NM_003566.3	NP_003557.2	Q15075	EEA1_HUMAN	early endosome antigen 1	612	Gln/Glu/Lys-rich.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(11)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	36						CACGGTCTTGTGCAGCTCTAA	0.408000													8	115					0	0	1	0	0
TPK1	27010	broad.mit.edu	37	7	144320274	144320274	+	Missense_Mutation	SNP	T	T	G			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr7:144320274T>G	ENST00000360057.3	-	6	441	c.339A>C	c.(337-339)gaA>gaC	p.E113D	TPK1_ENST00000538212.2_Missense_Mutation_p.E108D|TPK1_ENST00000378099.3_Missense_Mutation_p.E113D|TPK1_ENST00000549981.1_5'UTR|TPK1_ENST00000547966.1_5'UTR	NM_022445.3	NP_071890.2	Q9H3S4	TPK1_HUMAN	thiamin pyrophosphokinase 1	113					thiamine diphosphate biosynthetic process	cytosol	ATP binding|kinase activity|thiamine diphosphokinase activity			large_intestine(3)|lung(12)|ovary(2)|urinary_tract(2)	19					Thiamine(DB00152)	AGTCTTTTTCTTCTATCTTCT	0.318000													17	142					0	0	1	0	0
UBE4B	10277	broad.mit.edu	37	1	10209326	10209326	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr1:10209326A>T	ENST00000377157.3	+	19	3002	c.1941A>T	c.(1939-1941)ttA>ttT	p.L647F	UBE4B_ENST00000253251.8_Missense_Mutation_p.L763F|UBE4B_ENST00000343090.6_Missense_Mutation_p.L892F	NM_006048.4	NP_006039.2	O95155	UBE4B_HUMAN	ubiquitination factor E4B	892					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			NS(3)|breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(14)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	48		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		CAGAATTTTTATTTTTTATTG	0.303000													10	78					0	0	1	0	0
POF1B	79983	broad.mit.edu	37	X	84634367	84634367	+	Silent	SNP	G	G	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chrX:84634367G>A	ENST00000262753.4	-	2	238	c.93C>T	c.(91-93)caC>caT	p.H31H	POF1B_ENST00000373145.3_Silent_p.H31H	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	31							actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						GATGGTAGCAGTGGTAATGCT	0.562000													7	19					0	0	1	0	0
KLK15	55554	broad.mit.edu	37	19	51330313	51330313	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr19:51330313C>A	ENST00000326856.4	-	4	428	c.299G>T	c.(298-300)cGc>cTc	p.R100L	KLK15_ENST00000301421.2_Missense_Mutation_p.R101L|KLK15_ENST00000598239.1_Missense_Mutation_p.R101L|KLK15_ENST00000416184.1_Missense_Mutation_p.R101L|KLK15_ENST00000596931.1_Missense_Mutation_p.R100L	NM_001277081.1	NP_001264010.1	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15	101	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		GCGGTGGCTGCGCGCTTCGTA	0.677000													9	71					5.4927e-09	8.33714e-09	1	1	0
IRX6	79190	broad.mit.edu	37	16	55362818	55362818	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr16:55362818G>C	ENST00000290552.7	+	5	2260	c.928G>C	c.(928-930)Ggc>Cgc	p.G310R	RP11-26L20.3_ENST00000558730.2_RNA	NM_024335.2	NP_077311.2	P78412	IRX6_HUMAN	iroquois homeobox 6	310						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(2)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33						CAGGGAGTGCGGCCTGGCTGC	0.652000													8	80					0	0	1	0	0
KCNA5	3741	broad.mit.edu	37	12	5153877	5153877	+	Silent	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr12:5153877G>T	ENST00000252321.3	+	1	793	c.564G>T	c.(562-564)ccG>ccT	p.P188P		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	188				RP -> G (in Ref. 1; AAA61276).		Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						TGCGGAGGCCGGTCAACGTCT	0.622000													6	68					0.0215528	0.0229956	1	1	0
KRT73	319101	broad.mit.edu	37	12	53005055	53005055	+	Missense_Mutation	SNP	T	T	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr12:53005055T>C	ENST00000305748.3	-	6	1077	c.1043A>G	c.(1042-1044)aAt>aGt	p.N348S	RP11-641A6.2_ENST00000551089.1_RNA|RP11-641A6.2_ENST00000552364.1_RNA	NM_175068.2	NP_778238.1	Q86Y46	K2C73_HUMAN	keratin 73	348	Coil 2.|Rod.					keratin filament	structural molecule activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.189)		TGAGATCTCATTTTTGGTGTG	0.537000													9	94					0	0	1	0	0
PRKACB	5567	broad.mit.edu	37	1	84668381	84668381	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr1:84668381G>T	ENST00000370689.2	+	8	922	c.658G>T	c.(658-660)Gtg>Ttg	p.V220L	PRKACB_ENST00000394838.2_Missense_Mutation_p.V227L|PRKACB_ENST00000370682.3_Missense_Mutation_p.V224L|PRKACB_ENST00000370680.1_Missense_Mutation_p.V226L|PRKACB_ENST00000370685.3_Missense_Mutation_p.V267L|PRKACB_ENST00000370688.3_Missense_Mutation_p.V220L|PRKACB_ENST00000394839.2_Missense_Mutation_p.V190L	NM_001242862.1|NM_002731.2	NP_001229791.1|NP_002722.1	P22694	KAPCB_HUMAN	protein kinase, cAMP-dependent, catalytic, beta	220	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|regulation of insulin secretion|synaptic transmission|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|magnesium ion binding|protein binding			breast(1)|endometrium(2)|kidney(1)|lung(11)|ovary(1)	16				all cancers(265;0.00536)|Epithelial(280;0.0161)|OV - Ovarian serous cystadenocarcinoma(397;0.141)		CAATAAGGCAGTGGATTGGTG	0.378000													8	123					5.4927e-09	8.33714e-09	1	1	0
KCNH6	81033	broad.mit.edu	37	17	61607561	61607561	+	Silent	SNP	C	C	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr17:61607561C>T	ENST00000583023.1	+	3	428	c.417C>T	c.(415-417)tgC>tgT	p.C139C	KCNH6_ENST00000580652.1_Silent_p.C139C|KCNH6_ENST00000581784.1_Silent_p.C139C|KCNH6_ENST00000314672.5_Silent_p.C139C|KCNH6_ENST00000456941.2_Silent_p.C139C	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	139	PAC.				regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	TGGCCAAGTGCAGCAGCCGCA	0.632000													5	47					0	0	1	0	0
OCA2	4948	broad.mit.edu	37	15	28230313	28230313	+	Silent	SNP	G	G	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr15:28230313G>T	ENST00000354638.3	-	13	1416	c.1261C>A	c.(1261-1263)Cgg>Agg	p.R421R	OCA2_ENST00000353809.5_Silent_p.R397R|OCA2_ENST00000382996.2_Silent_p.R421R	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	421					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding	p.R421W(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		GCCCACACCCGTCCCCGGGAG	0.572000									Oculocutaneous Albinism				5	25					5.9392e-07	8.5084e-07	1	1	0
GABRA6	2559	broad.mit.edu	37	5	161119121	161119121	+	Missense_Mutation	SNP	A	A	G			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr5:161119121A>G	ENST00000523217.1	+	8	1213	c.971A>G	c.(970-972)aAg>aGg	p.K324R	GABRA6_ENST00000274545.5_Missense_Mutation_p.K334R	NM_000811.2	NP_000802.2	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 6	334					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|liver(2)|lung(22)|ovary(7)|skin(6)|urinary_tract(2)	57	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CAGACACAGAAGGCCAAAAGG	0.438000										TCGA Ovarian(5;0.080)			9	88					0	0	1	0	0
EFCAB12	90288	broad.mit.edu	37	3	129123224	129123224	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr3:129123224C>G	ENST00000505956.1	-	7	1434	c.1272G>C	c.(1270-1272)aaG>aaC	p.K424N	EFCAB12_ENST00000326085.3_Missense_Mutation_p.K424N	NM_207307.1	NP_997190.1			EF-hand calcium binding domain 12																		GGAAAATGATCTTGTCTCCTG	0.567000													7	103					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103341396	103341396	+	Missense_Mutation	SNP	T	T	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr7:103341396T>C	ENST00000424685.2	-	9	1022	c.863A>G	c.(862-864)aAg>aGg	p.K288R	RELN_ENST00000428762.1_Missense_Mutation_p.K288R|RELN_ENST00000343529.5_Missense_Mutation_p.K288R			P78509	RELN_HUMAN	reelin	288					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AGAGTTATTCTTGGCATATAA	0.343000													10	114					0	0	1	0	0
SMEK1	55671	broad.mit.edu	37	14	91928502	91928502	+	Silent	SNP	T	T	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr14:91928502T>A	ENST00000554684.1	-	13	2512	c.2016A>T	c.(2014-2016)acA>acT	p.T672T	SMEK1_ENST00000555462.1_Silent_p.T446T|SMEK1_ENST00000554943.1_Silent_p.T685T|SMEK1_ENST00000428424.2_Silent_p.T446T|SMEK1_ENST00000337238.4_Silent_p.T672T|SMEK1_ENST00000555718.1_5'UTR			Q6IN85	P4R3A_HUMAN	SMEK homolog 1, suppressor of mek1 (Dictyostelium)	685						microtubule organizing center|nucleus	protein binding			NS(1)|endometrium(1)|kidney(1)|liver(1)|lung(1)|stomach(1)	6		all_cancers(154;0.0691)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.221)		CATCTTCATCTGTGTTAAACC	0.368000													7	32					0	0	1	0	0
GGA2	23062	broad.mit.edu	37	16	23491168	23491168	+	Silent	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr16:23491168C>A	ENST00000309859.4	-	11	1129	c.1047G>T	c.(1045-1047)ctG>ctT	p.L349L	GGA2_ENST00000567468.1_Intron|GGA2_ENST00000569182.1_5'UTR	NM_015044.4	NP_055859.1	Q9UJY4	GGA2_HUMAN	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	349	Unstructured hinge.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|clathrin-coated vesicle|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(4)|ovary(1)	21				GBM - Glioblastoma multiforme(48;0.0386)		CCAAGTCAATCAGGGGGCAGG	0.537000													8	41					0.0381472	0.039867	1	1	0
TMEM246	84302	broad.mit.edu	37	9	104238240	104238240	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr9:104238240C>A	ENST00000374851.1	-	4	2282	c.1135G>T	c.(1135-1137)Gta>Tta	p.V379L	RP11-490D19.6_ENST00000425734.1_RNA|TMEM246_ENST00000374848.3_Missense_Mutation_p.V379L|RP11-490D19.6_ENST00000431507.1_RNA|RP11-490D19.6_ENST00000424154.1_RNA|TMEM246_ENST00000374847.1_Missense_Mutation_p.V379L|RP11-490D19.6_ENST00000450109.1_RNA			Q9BRR3	CI125_HUMAN	transmembrane protein 246	379						integral to membrane											GGCTCCACTACATAGGCCCTC	0.562000													7	66					0.248553	0.249531	1	1	0
EPHA6	285220	broad.mit.edu	37	3	97311492	97311492	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr3:97311492C>A	ENST00000389672.5	+	12	2461	c.2423C>A	c.(2422-2424)cCc>cAc	p.P808H	EPHA6_ENST00000514100.1_Missense_Mutation_p.P200H|EPHA6_ENST00000502694.1_Missense_Mutation_p.P200H|EPHA6_ENST00000442602.2_Missense_Mutation_p.P174H	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	713	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						GCGTTTTGCCCCAGCTTCCTG	0.483000													8	50					1.12685e-05	1.50443e-05	1	1	0
FANCA	2175	broad.mit.edu	37	16	89851301	89851301	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr16:89851301C>A	ENST00000389301.3	-	15	1461	c.1431G>T	c.(1429-1431)ttG>ttT	p.L477F	FANCA_ENST00000568369.1_Missense_Mutation_p.L477F	NM_000135.2	NP_000126.2	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A	477					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			breast(5)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|urinary_tract(3)	47		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		CGAGTTCTGACAAGAACGTAA	0.567000			"""D, Mis, N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				7	143					0.0381472	0.039867	1	1	0
RABGAP1	23637	broad.mit.edu	37	9	125860076	125860076	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr9:125860076G>C	ENST00000373647.4	+	22	2819	c.2685G>C	c.(2683-2685)ttG>ttC	p.L895F	RABGAP1_ENST00000373643.5_Missense_Mutation_p.L234F	NM_012197.3	NP_036329.3	Q9Y3P9	RBGP1_HUMAN	RAB GTPase activating protein 1	895					cell cycle	centrosome|cytosol|microtubule associated complex	Rab GTPase activator activity|tubulin binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(3)|prostate(4)|stomach(3)|upper_aerodigestive_tract(1)	41						AACAGAAGTTGATTGATGCAG	0.443000													8	52					0	0	1	0	0
RAB6B	51560	broad.mit.edu	37	3	133557037	133557037	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr3:133557037A>T	ENST00000285208.4	-	6	817	c.468T>A	c.(466-468)agT>agA	p.S156R	RAB6B_ENST00000543906.1_Missense_Mutation_p.S156R|RAB6B_ENST00000486858.1_Missense_Mutation_p.S143R|RAB6B_ENST00000469959.1_Intron	NM_016577.3	NP_057661.3	Q9NRW1	RAB6B_HUMAN	RAB6B, member RAS oncogene family	156					protein transport|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|Golgi membrane	GTP binding|GTPase activity|protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)	11						CAGTCTTCGCACTGGTCTCAA	0.617000													13	191					0	0	1	0	0
PER3	8863	broad.mit.edu	37	1	7887578	7887579	+	Frame_Shift_Ins	INS	-	-	G	rs228697	byFrequency	TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr1:7887578_7887579insG	ENST00000377532.3	+	17	2813_2814	c.2589_2590insG	c.(2587-2592)ccctgtfs	p.C864fs	PER3_ENST00000361923.2_Frame_Shift_Ins_p.C856fs			P56645	PER3_HUMAN	period circadian clock 3	856	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	39	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		TGCCTGACCCCCCTGTCTGTCC	0.545													25	240	---	---	---	---					
AC073321.4	0	broad.mit.edu	37	2	217475032	217475032	+	RNA	DEL	A	A	-	rs71401156		TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr2:217475032delA	ENST00000441803.1	+	0	195																											ATTTTATTTCAAAAAAAAAAA	0.373													3	5	---	---	---	---					
GABBR1	2550	broad.mit.edu	37	6	29573436	29573438	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr6:29573436_29573438delCAG	ENST00000377034.4	-	20	2682_2684	c.2347_2349delCTG	c.(2347-2349)del	p.L783del	GABBR1_ENST00000377016.4_In_Frame_Del_p.L721del|GABBR1_ENST00000376977.3_3'UTR|GABBR1_ENST00000355973.3_In_Frame_Del_p.L666del|GABBR1_ENST00000377012.4_In_Frame_Del_p.L666del	NM_001470.2	NP_001461.1	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 1	783					gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity	p.L783M(1)		endometrium(3)|kidney(1)|large_intestine(13)|liver(1)|lung(16)|ovary(5)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47					Baclofen(DB00181)|Progabide(DB00837)	GGAAGATTCCCAGCAGCAGCAGC	0.512													7	89	---	---	---	---					
SSPO	23145	broad.mit.edu	37	7	149518533	149518533	+	RNA	DEL	C	C	-	rs11353848		TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr7:149518533delC	ENST00000378016.2	+	0	12602							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GAGGAGCAGTCCCAGAGCCAG	0.711													2	4	---	---	---	---					
XKR5	389610	broad.mit.edu	37	8	6673269	6673270	+	RNA	INS	-	-	A	rs112269595		TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr8:6673269_6673270insA	ENST00000518724.1	-	0	1071							Q6UX68	XKR5_HUMAN	XK, Kell blood group complex subunit-related family, member 5							integral to membrane				endometrium(1)|large_intestine(1)|lung(1)	3			STAD - Stomach adenocarcinoma(24;0.0984)	READ - Rectum adenocarcinoma(644;0.137)|COAD - Colon adenocarcinoma(149;0.166)		GAGCCCATTGTAAAAAAAAAAA	0.505											OREG0018511	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	3	---	---	---	---					
ZFHX4	79776	broad.mit.edu	37	8	77768487	77768488	+	Frame_Shift_Ins	INS	-	-	A			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr8:77768487_77768488insA	ENST00000521891.2	+	10	9778_9779	c.9330_9331insA	c.(9328-9333)ccgaatfs	p.N3111fs	ZFHX4_ENST00000455469.2_Frame_Shift_Ins_p.N3066fs|ZFHX4_ENST00000050961.6_Frame_Shift_Ins_p.N3066fs|ZFHX4_ENST00000518282.1_Frame_Shift_Ins_p.N3085fs	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	3066	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P3094P(1)		NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCCTTCTCCCCGGAATGAACGG	0.525										HNSCC(33;0.089)			19	81	---	---	---	---					
MT1G	4495	broad.mit.edu	37	16	56700870	56700870	+	Frame_Shift_Del	DEL	C	C	-			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr16:56700870delC	ENST00000444837.2	-	3	178	c.107delG	c.(106-108)tcfs	p.C37fs	MT1G_ENST00000379811.3_Frame_Shift_Del_p.C38fs|MT1G_ENST00000568675.1_3'UTR|MT1G_ENST00000569500.1_Frame_Shift_Del_p.C15fs	NM_005950.1	NP_005941.1	P13640	MT1G_HUMAN	metallothionein 1G	38	Alpha.						metal ion binding|protein binding			kidney(2)|large_intestine(1)|lung(2)	5						CACAGGGCAGCAGGAGCAGCA	0.632													11	176	---	---	---	---					
SLC47A2	146802	broad.mit.edu	37	17	19611118	19611119	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-97-A4LX-01A-11D-A24P-08	TCGA-97-A4LX-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19784a3-e8f2-4083-b210-837a8a82a232	0b080b7d-3d53-4264-baa2-5a3b9d727306	g.chr17:19611118_19611119delTG	ENST00000350657.5	-	8	841_842	c.667_668delCA	c.(667-669)gfs	p.Q223fs	SLC47A2_ENST00000325411.5_Frame_Shift_Del_p.Q259fs|SLC47A2_ENST00000463318.1_5'UTR	NM_001099646.1|NM_001256663.1	NP_001093116.1|NP_001243592.1	Q86VL8	S47A2_HUMAN	solute carrier family 47 (multidrug and toxin extrusion), member 2	259						integral to membrane|plasma membrane	drug:hydrogen antiporter activity			endometrium(2)|kidney(3)|large_intestine(2)|lung(1)|ovary(1)	9	all_cancers(12;2.3e-05)|all_epithelial(12;0.0024)|Breast(13;0.245)					GAAGACGGTCTGTGCAAACTGG	0.619													2	4	---	---	---	---